changes

_posts/2024-04-14-blog-post.md.md

@@ -35,10 +35,10 @@ During my academic journey, I had the opportunity to participate in four impactf
         At the first sight, one might say that heterochromatin is more compacted than euchromatin because of that. But the compaction degree of hetero/euchromatin is still unclear. Indeed, it is a 3D polymer which is dynamic. It's "biological essence" can't be depicted through one image. 
 
         Another way to look at it is through the scope of genetic information, specifically epigenetics. If you are not familiar with epigenetics, I suggest reading the article "Epigenetics: The Origin and Evolution of a Fashionable Topic" by Ute Deichmann in Developmental Biology (416: 249-254). In summary, the term "epigenetics" was coined by embryologist Conrad Waddington in 1942, but it builds upon ideas from the 17th century. Although it followed the genetic revolution of the mid-20th century, epigenetics has become a significant field of study in its own right. It started to grow after the operon model of Jacob and Monod in 1961, two french biologists who got the Nobel Prize in Medicine and Physiology for their research in 1965. Epigenetics is defined by the Cambridge dictionnary as "a branch of genetics that studies the chemical reactions that turn genes on and off". The main questions that arise then are : How are genes turned on and off ? Is it heritable through cell division ? Is it heritable after reproduction ? 
-        To study that kind of questions the model organism is the fission yeast or *schizosaccharomyces pombe*. Unicellular organism, this yeast has still the same kind of regulatory pathways of gene expression and DNA repair. Another way to study those questions is through coarse-grained modeling. **[TO COMPLETE]**
+        To study that kind of questions the model organism is the fission yeast or *schizosaccharomyces pombe*. Unicellular organism, this yeast has still the same kind of regulatory pathways of gene expression and DNA repair. Another way to study those questions is through coarse-grained modeling. That is the two approaches I use during my internship. 
 
 
-        To look at the dynamics of heterochromatin, its behavior, its nucleation, its spreading (local or global or both), the effect of environmental parameters within the cell or the genome, the polymeric effect of chromatin on itself (coiled transition for example), the effect of proteins on the modification of histones through liquid-liquid phase separation for example (and a lot of other interesting scientific questions) I did the following :
+        To look at the dynamics of heterochromatin, its behavior, its nucleation, its spreading (local or global or both), the effect of environmental parameters within the cell or the genome, the polymer effect of chromatin on itself (coile-globule transition for example), the effect of proteins on the modification of histones through liquid-liquid phase separation for example (and a lot of other interesting scientific questions) I did the following :
 
         - Model and simulate in 1D the chromatin with local and global changes, transcription and replication effects using Python from scratch (see GitHub - replication of the results of a previous article by Kim Sneppen, 2007)
         - Model and simulate in 3D the chromatin with global changes using Reactive Molecular Dynamics with LAMMPS and the REACTOR package modified especially for this project by Jacob Gissinger.
@@ -56,16 +56,16 @@ During my academic journey, I had the opportunity to participate in four impactf
     - Supervisor : Dr. Maxime Deforet
     - Location : Laboratoire Jean Perrin - Sorbonne Université (Paris)
     - Duration: End of spring and Summer 2023
-    - Description: *Pseudomonas aeruginosa* is a pathogenic bacteria for humans in the case of immunodeficiency. It is the third bacteria responsible for nosocomial infections. It is interesting to understand its development capacity and a specific type of motility: **swarming**. This motility, specific to bacteria, is the emergence of collective movement within a bacterial colony, based on various physical effects such as the Marangoni effect through the production of surfactants by bacteria: rhamnolipids. From a fundamental point of view, it is interesting to understand, at different scales, the emergence of collective movement with individuals that do not have direct awareness of their environment, but only through physicochemical effects. This ability allows bacteria to understand their surroundings, including their density. The goal of this internship was to create a multi-scale dynamic atlas - mapping - of swarming in *p.aeruginosa* using optical microscopy. This was done to quantitatively understand and analyze the internal activity within the population of bacteria through MSD calculation using fluorescence. The characterization of polymers produced during swarming in one of the mutants used, which may influence internal mobility by changing the viscoelastic properties of the environment, constituted the second part of the internship.
-    **[TO COMPLETE]**
+    - Description: *Pseudomonas aeruginosa* is a pathogenic bacteria for humans in the case of immunodeficiency. It is the third bacteria responsible for nosocomial infections. It is interesting to understand its development capacity and a specific type of motility: **swarming**. This motility, specific to bacteria, is the emergence of collective movement within a bacterial colony, based on various physical effects such as the Marangoni effect through the production of surfactants by bacteria: rhamnolipids. From a fundamental point of view, it is interesting to understand, at different scales, the emergence of collective movement with individuals that do not have direct awareness of their environment, but only through physicochemical effects. This ability allows bacteria to understand their surroundings, including their density. The goal of this internship was to create a multi-scale dynamic atlas - mapping - of swarming in *p.aeruginosa* using optical microscopy. This was done to quantitatively understand and analyze the internal activity within the population of bacteria through MSD calculation using fluorescence. The characterization of polymers produced during swarming in one of the mutants used, which may influence internal mobility by changing the viscoelastic properties of the environment, constituted the second part of the internship. 
 
     - [Link to french report Internship LJP by Adrien Berard 2023](https://adrien-berard.github.io/files/RapportStage_LJP2023-6.pdf)
 
 3. **Multiparamaters’ evaluation of cardiac dynamic using ultra-fast echocardiography**
     - Supervisors : Dr. Mathieu Pernot & Dr. Olivier Pedreira
     - Location : Physics for Medicine lab - ESPCI (Paris)
     - Duration: Fall 2022
-    - Description: [brief description of the internship project and tasks]
+    - Description: This internship focused on the multiparametric evaluation of cardiac dynamics using ultra-fast echocardiography. I joined a research team at the Physics for Medicine laboratory in Paris, which specializes in innovative ultrasound imaging concepts, particularly in cardiovascular applications. The internship aimed to develop methods for assessing cardiac dynamics and tracking using echocardiographic images obtained from the Cardioscope, a device developed by the laboratory. The intern's tasks included data handling, formatting clinical data, and implementing algorithms for image processing and analysis, including tissue Doppler imaging and speckle tracking. The ultimate goal was to provide valuable parameters for diagnosing cardiovascular pathologies, particularly focusing on heart failure.
+
     - [Link to french report Internship Physics for Medicin by Adrien Berard 2022](https://adrien-berard.github.io/files/Rapport_de_stage_CPES3_PhysM_BERARD_ADRIEN.pdf)
 
 4. **Molecular dynamics simulation of a minimal elastic catalyst model**

_posts/2024-04-15-blog-post.md.md

@@ -115,5 +115,5 @@ Plan for the week :
 -   Monday : same 
 -   Tuesday : danish class
 
-ra
+