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Is there a maximum of subclones? #93

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augjensen opened this issue Nov 27, 2023 · 2 comments
Open

Is there a maximum of subclones? #93

augjensen opened this issue Nov 27, 2023 · 2 comments

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@augjensen
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Thank you for this SCEVAN tool which I use a lot at the moment,

I am analysing merged datasets to investigate patient-specificity among CNV subclones. However, using a merged dataset of 24 donors, generating 12 subclones, there was an error at the end of the analysis pipeline. How should I interpret this error? Is there a maximum to the amount of subclones that can be analyzed (9)?

image

Thanks in advance!

@DGladish
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DGladish commented Feb 8, 2024

I am also curious about this. I am analyzing two samples from the same patient (taken at different times). With these datasets merged in datasets from 2 healthy donors (P1 + H1/H2, P2 + H1/H2, P1+P2+H1/H2), and specified these as the healthy cells. When I do these 3 runs, the number of subclones produce from the runs on the individual datasets are more than the number of subclones from the runs on the merged dataset.

P1+H1/H2: 5 subclones
P2+H1/H2: 5 subclones
P1+P2+H1/H2: 6 subclones

@naila53
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naila53 commented Nov 12, 2024

@augjensen wondering if you managed to figure out this issue?I'm facing the same error when merging samples however it works fine when running the pipeline on individual samples.

Screenshot 2024-11-12 at 2 27 47 PM

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3 participants