[User Story] Tumor in normal contamination filter in VarDict

[mathiasbio]

Need

As a clinician I want to avoid needing to interpret artefacts, currently the VarDict filter for presence of the variant in normal is based strictly on whether the variant in the tumor is observed in roughly above 5% in the normal. (See: #1256) This is a strict filter for variants with high frequency in the tumor, allowing very little tumor in normal contamination, while being very relaxed for low frequency variants which are commonly artefacts. By applying a relative fraction as was done for TNscope previously (see: #1335) we can remove variants which are about equally represented in tumor and normal and which are commonly artefacts.

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