diff --git a/internal/controller/datadogagent/controller_reconcile_agent.go b/internal/controller/datadogagent/controller_reconcile_agent.go
index 54fcdb42d..c2bd34fcd 100644
--- a/internal/controller/datadogagent/controller_reconcile_agent.go
+++ b/internal/controller/datadogagent/controller_reconcile_agent.go
@@ -378,7 +378,7 @@ func (r *Reconciler) cleanupPodsForProfilesThatNoLongerApply(ctx context.Context
 					Name:      agentPod.Name,
 				},
 			}
-			if err = r.client.Delete(ctx, &toDelete); err != nil {
+			if err = r.client.Delete(ctx, &toDelete); err != nil && !errors.IsNotFound(err) {
 				return err
 			}
 		}
diff --git a/internal/controller/datadogagent/controller_reconcile_agent_test.go b/internal/controller/datadogagent/controller_reconcile_agent_test.go
index 4cc45bdd4..307aaebc9 100644
--- a/internal/controller/datadogagent/controller_reconcile_agent_test.go
+++ b/internal/controller/datadogagent/controller_reconcile_agent_test.go
@@ -1841,3 +1841,226 @@ func Test_labelNodesWithProfiles(t *testing.T) {
 		})
 	}
 }
+
+func Test_cleanupPodsForProfilesThatNoLongerApply(t *testing.T) {
+	sch := runtime.NewScheme()
+	_ = scheme.AddToScheme(sch)
+	ctx := context.Background()
+
+	testCases := []struct {
+		name           string
+		description    string
+		profilesByNode map[string]types.NamespacedName
+		ddaNamespace   string
+		existingPods   []client.Object
+		wantPods       []corev1.Pod
+	}{
+		{
+			name:        "delete agent pod that shouldn't be running",
+			description: "pod-2 should be deleted",
+			profilesByNode: map[string]types.NamespacedName{
+				"node-1": {
+					Namespace: "foo",
+					Name:      "profile-1",
+				},
+				"node-2": {
+					Namespace: "foo",
+					Name:      "profile-2",
+				},
+				"node-default": {
+					Namespace: "",
+					Name:      "default",
+				},
+			},
+			ddaNamespace: "foo",
+			existingPods: []client.Object{
+				&corev1.Pod{
+					ObjectMeta: metav1.ObjectMeta{
+						Name:      "pod-1",
+						Namespace: "foo",
+						Labels: map[string]string{
+							apicommon.AgentDeploymentComponentLabelKey: constants.DefaultAgentResourceSuffix,
+							agentprofile.ProfileLabelKey:               "profile-1",
+						},
+					},
+					Spec: corev1.PodSpec{
+						NodeName: "node-1",
+					},
+				},
+				&corev1.Pod{
+					ObjectMeta: metav1.ObjectMeta{
+						Name:      "pod-2",
+						Namespace: "foo",
+						Labels: map[string]string{
+							apicommon.AgentDeploymentComponentLabelKey: constants.DefaultAgentResourceSuffix,
+							agentprofile.ProfileLabelKey:               "profile-1",
+						},
+					},
+					Spec: corev1.PodSpec{
+						NodeName: "node-2",
+					},
+				},
+			},
+			wantPods: []corev1.Pod{
+				{
+					ObjectMeta: metav1.ObjectMeta{
+						Name:      "pod-1",
+						Namespace: "foo",
+						Labels: map[string]string{
+							apicommon.AgentDeploymentComponentLabelKey: constants.DefaultAgentResourceSuffix,
+							agentprofile.ProfileLabelKey:               "profile-1",
+						},
+						ResourceVersion: "999",
+					},
+					Spec: corev1.PodSpec{
+						NodeName: "node-1",
+					},
+				},
+			},
+		},
+		{
+			name:        "delete default agent on profile node",
+			description: "pod-2 should be deleted",
+			profilesByNode: map[string]types.NamespacedName{
+				"node-1": {
+					Namespace: "foo",
+					Name:      "profile-1",
+				},
+				"node-2": {
+					Namespace: "foo",
+					Name:      "profile-2",
+				},
+				"node-default": {
+					Namespace: "",
+					Name:      "default",
+				},
+			},
+			ddaNamespace: "foo",
+			existingPods: []client.Object{
+				&corev1.Pod{
+					ObjectMeta: metav1.ObjectMeta{
+						Name:      "pod-1",
+						Namespace: "foo",
+						Labels: map[string]string{
+							apicommon.AgentDeploymentComponentLabelKey: constants.DefaultAgentResourceSuffix,
+							agentprofile.ProfileLabelKey:               "profile-1",
+						},
+					},
+					Spec: corev1.PodSpec{
+						NodeName: "node-1",
+					},
+				},
+				&corev1.Pod{
+					ObjectMeta: metav1.ObjectMeta{
+						Name:      "pod-default",
+						Namespace: "foo",
+						Labels: map[string]string{
+							apicommon.AgentDeploymentComponentLabelKey: constants.DefaultAgentResourceSuffix,
+						},
+					},
+					Spec: corev1.PodSpec{
+						NodeName: "node-2",
+					},
+				},
+			},
+			wantPods: []corev1.Pod{
+				{
+					ObjectMeta: metav1.ObjectMeta{
+						Name:      "pod-1",
+						Namespace: "foo",
+						Labels: map[string]string{
+							apicommon.AgentDeploymentComponentLabelKey: constants.DefaultAgentResourceSuffix,
+							agentprofile.ProfileLabelKey:               "profile-1",
+						},
+						ResourceVersion: "999",
+					},
+					Spec: corev1.PodSpec{
+						NodeName: "node-1",
+					},
+				},
+			},
+		},
+		{
+			name:        "delete profile agent on default node",
+			description: "pod-2 should be deleted",
+			profilesByNode: map[string]types.NamespacedName{
+				"node-1": {
+					Namespace: "foo",
+					Name:      "profile-1",
+				},
+				"node-2": {
+					Namespace: "foo",
+					Name:      "profile-2",
+				},
+				"node-default": {
+					Namespace: "",
+					Name:      "default",
+				},
+			},
+			ddaNamespace: "foo",
+			existingPods: []client.Object{
+				&corev1.Pod{
+					ObjectMeta: metav1.ObjectMeta{
+						Name:      "pod-1",
+						Namespace: "foo",
+						Labels: map[string]string{
+							apicommon.AgentDeploymentComponentLabelKey: constants.DefaultAgentResourceSuffix,
+							agentprofile.ProfileLabelKey:               "profile-1",
+						},
+					},
+					Spec: corev1.PodSpec{
+						NodeName: "node-1",
+					},
+				},
+				&corev1.Pod{
+					ObjectMeta: metav1.ObjectMeta{
+						Name:      "pod-2",
+						Namespace: "foo",
+						Labels: map[string]string{
+							apicommon.AgentDeploymentComponentLabelKey: constants.DefaultAgentResourceSuffix,
+							agentprofile.ProfileLabelKey:               "profile-2",
+						},
+					},
+					Spec: corev1.PodSpec{
+						NodeName: "node-default",
+					},
+				},
+			},
+			wantPods: []corev1.Pod{
+				{
+					ObjectMeta: metav1.ObjectMeta{
+						Name:      "pod-1",
+						Namespace: "foo",
+						Labels: map[string]string{
+							apicommon.AgentDeploymentComponentLabelKey: constants.DefaultAgentResourceSuffix,
+							agentprofile.ProfileLabelKey:               "profile-1",
+						},
+						ResourceVersion: "999",
+					},
+					Spec: corev1.PodSpec{
+						NodeName: "node-1",
+					},
+				},
+			},
+		},
+	}
+
+	for _, tt := range testCases {
+		t.Run(tt.name, func(t *testing.T) {
+			fakeClient := fake.NewClientBuilder().WithScheme(sch).WithObjects(tt.existingPods...).Build()
+
+			r := &Reconciler{
+				client: fakeClient,
+			}
+
+			err := r.cleanupPodsForProfilesThatNoLongerApply(ctx, tt.profilesByNode, tt.ddaNamespace)
+			assert.NoError(t, err)
+
+			podList := &corev1.PodList{}
+			err = fakeClient.List(ctx, podList)
+			assert.NoError(t, err)
+			assert.Len(t, podList.Items, len(tt.wantPods))
+			assert.Equal(t, tt.wantPods, podList.Items)
+		})
+	}
+}