diff --git a/apps/node_man/models.py b/apps/node_man/models.py
index 6954224fe..2f4c701a2 100644
--- a/apps/node_man/models.py
+++ b/apps/node_man/models.py
@@ -152,6 +152,8 @@ class KeyEnum(Enum):
         ADD_HOST_CLOUD_BLACKLIST = "ADD_HOST_CLOUD_BLACKLIST"
         # 消息中心开关
         ENABLE_NOTICE_CENTER = "ENABLE_NOTICE_CENTER"
+        # 禁用已停用插件
+        DISABLE_STOPPED_PLUGIN = "DISABLE_STOPPED_PLUGIN"
 
     key = models.CharField(_("键"), max_length=255, db_index=True, primary_key=True)
     v_json = JSONField(_("值"))
diff --git a/apps/node_man/serializers/plugin.py b/apps/node_man/serializers/plugin.py
index dc9d0a6c3..ff2e6bfce 100644
--- a/apps/node_man/serializers/plugin.py
+++ b/apps/node_man/serializers/plugin.py
@@ -22,7 +22,13 @@
     JobType,
     ProcType,
 )
-from apps.node_man.models import GsePluginDesc, Packages, ProcControl, ProcessStatus
+from apps.node_man.models import (
+    GlobalSettings,
+    GsePluginDesc,
+    Packages,
+    ProcControl,
+    ProcessStatus,
+)
 from apps.node_man.serializers import base
 
 
@@ -248,6 +254,10 @@ def validate(self, attrs):
             raise ValidationError(_("插件参数 plugin_params 和 plugin_params_list 参数不能同时为空"))
 
         if attrs.get("plugin_params"):
+            if GlobalSettings.get_config(key=GlobalSettings.KeyEnum.DISABLE_STOPPED_PLUGIN.value, default=True):
+                plugin_name = attrs["plugin_params"]["name"]
+                if GsePluginDesc.objects.filter(name=plugin_name, is_ready=False).first() is not None:
+                    raise ValidationError(_("插件{}已被禁用，不能执行相关操作").format(plugin_name))
             # 把2.0.x 的参数转为 2.1.x 的参数
             attrs["plugin_params_list"] = [attrs.get("plugin_params")]
 
diff --git a/apps/node_man/tests/test_views/test_plugins.py b/apps/node_man/tests/test_views/test_plugins.py
index d56e08d5b..575fdfa94 100644
--- a/apps/node_man/tests/test_views/test_plugins.py
+++ b/apps/node_man/tests/test_views/test_plugins.py
@@ -55,3 +55,23 @@ def test_common_plugin_list(self):
         response = self.client.get(f"/api/plugin/{self.PLUGIN_NAME}/package/", {"os": "LINUX"})
         self.assertFalse(response["result"])
         self.assertRegex(response["message"], r"bk_collector_not-found in.*")
+
+
+class PluginOperateViewTestCase(PluginViewTestCase):
+    PLUGIN_NAME = "stopped_plugin"
+
+    def setUp(self) -> None:
+        super().setUp()
+        models.GsePluginDesc.objects.filter(name=self.PLUGIN_NAME).update(is_ready=False)
+
+    def test_stopped_plugin_operate(self):
+        response = self.client.post(
+            "/api/plugin/operate/",
+            data={
+                "job_type": "MAIN_INSTALL_PLUGIN",
+                "bk_host_id": [111],
+                "plugin_params": {"name": "stopped_plugin", "version": "latest"},
+            },
+        )
+        self.assertFalse(response["result"])
+        self.assertEqual(response["message"], f"插件{self.PLUGIN_NAME}已被禁用，不能执行相关操作（3800001）")