diff --git a/extensions/cornerstone/src/utils/interleaveCenterLoader.ts b/extensions/cornerstone/src/utils/interleaveCenterLoader.ts
index d8f64b5d838..16ed7eeebc7 100644
--- a/extensions/cornerstone/src/utils/interleaveCenterLoader.ts
+++ b/extensions/cornerstone/src/utils/interleaveCenterLoader.ts
@@ -51,18 +51,25 @@ export default function interleaveCenterLoader({
    * listen to it and as the other viewports are created we can set the volumes for them
    * since volumes are already started loading.
    */
-  if (matchDetails.size !== viewportIdVolumeInputArrayMap.size) {
-    return;
-  }
+  const uniqueViewportVolumeDisplaySetUIDs = new Set();
+  viewportIdVolumeInputArrayMap.forEach((volumeInputArray, viewportId) => {
+    volumeInputArray.forEach(volumeInput => {
+      const { volumeId } = volumeInput;
+      uniqueViewportVolumeDisplaySetUIDs.add(volumeId);
+    });
+  });
 
-  // Check if all the matched volumes are loaded
-  for (const [_, details] of displaySetsMatchDetails.entries()) {
-    const { SeriesInstanceUID } = details;
+  const uniqueMatchedDisplaySetUIDs = new Set();
 
-    // HangingProtocol has matched, but don't have all the volumes created yet, so return
-    if (!Array.from(volumeIdMapsToLoad.values()).includes(SeriesInstanceUID)) {
-      return;
-    }
+  matchDetails.forEach(matchDetail => {
+    const { displaySetsInfo } = matchDetail;
+    displaySetsInfo.forEach(({ displaySetInstanceUID }) => {
+      uniqueMatchedDisplaySetUIDs.add(displaySetInstanceUID);
+    });
+  });
+
+  if (uniqueViewportVolumeDisplaySetUIDs.size !== uniqueMatchedDisplaySetUIDs.size) {
+    return;
   }
 
   const volumeIds = Array.from(volumeIdMapsToLoad.keys()).slice();
diff --git a/extensions/cornerstone/src/utils/interleaveTopToBottom.ts b/extensions/cornerstone/src/utils/interleaveTopToBottom.ts
index a0d1e4fb6fd..fc5447a423b 100644
--- a/extensions/cornerstone/src/utils/interleaveTopToBottom.ts
+++ b/extensions/cornerstone/src/utils/interleaveTopToBottom.ts
@@ -75,21 +75,25 @@ export default function interleaveTopToBottom({
    * listen to it and as the other viewports are created we can set the volumes for them
    * since volumes are already started loading.
    */
-  if (filteredMatchDetails.length !== viewportIdVolumeInputArrayMap.size) {
-    return;
-  }
+  const uniqueViewportVolumeDisplaySetUIDs = new Set();
+  viewportIdVolumeInputArrayMap.forEach((volumeInputArray, viewportId) => {
+    volumeInputArray.forEach(volumeInput => {
+      const { volumeId } = volumeInput;
+      uniqueViewportVolumeDisplaySetUIDs.add(volumeId);
+    });
+  });
 
-  // Check if all the matched volumes are loaded
-  for (const [_, details] of displaySetsMatchDetails.entries()) {
-    const { SeriesInstanceUID, displaySetInstanceUID } = details;
+  const uniqueMatchedDisplaySetUIDs = new Set();
 
-    // HangingProtocol has matched, but don't have all the volumes created yet, so return
-    if (
-      displaySetsToLoad.has(displaySetInstanceUID) &&
-      !Array.from(volumeIdMapsToLoad.values()).includes(SeriesInstanceUID)
-    ) {
-      return;
-    }
+  matchDetails.forEach(matchDetail => {
+    const { displaySetsInfo } = matchDetail;
+    displaySetsInfo.forEach(({ displaySetInstanceUID }) => {
+      uniqueMatchedDisplaySetUIDs.add(displaySetInstanceUID);
+    });
+  });
+
+  if (uniqueViewportVolumeDisplaySetUIDs.size !== uniqueMatchedDisplaySetUIDs.size) {
+    return;
   }
 
   const volumeIds = Array.from(volumeIdMapsToLoad.keys()).slice();