From 7d097b686c766e5b7d644c3931d061b1065a6d86 Mon Sep 17 00:00:00 2001 From: richard gowers Date: Fri, 1 Mar 2024 09:52:54 +0000 Subject: [PATCH] few tweaks to Lomap network notebook --- cookbook/generate_lomap_network.ipynb | 75 +++++++++++++++++++++++---- 1 file changed, 66 insertions(+), 9 deletions(-) diff --git a/cookbook/generate_lomap_network.ipynb b/cookbook/generate_lomap_network.ipynb index a0239a8..07183fe 100644 --- a/cookbook/generate_lomap_network.ipynb +++ b/cookbook/generate_lomap_network.ipynb @@ -5,7 +5,7 @@ "id": "035c0099-6892-4ed2-b0d6-80b1c247c1e7", "metadata": {}, "source": [ - "# Planning a Ligand Network" + "# Planning a Ligand Network with Lomap" ] }, { @@ -14,7 +14,7 @@ "metadata": {}, "source": [ "A [Ligand Network] is a graph of transformations between small molecules, typically such that every small molecule can reach every other small molecule via a series of transformations. This eventually forms the graph of the free energy campaign. A `LigandNetwork` can be generated from a collection of `SmallMoleculeComponent` instances by optimising over possible networks according to some criteria; in OpenFE, this involves combining a network generating strategy with a scoring function for individual mappings.\n", - "In this cookbook we are generating a [LOMAP] network. \n", + "In this cookbook we are generating a network using the network generator provided in [LOMAP].\n", "\n", "[Ligand Network]: https://docs.openfree.energy/en/stable/reference/api/generated/openfe.setup.LigandNetwork.html\n", "[LOMAP]: https://github.com/OpenFreeEnergy/Lomap/tree/main" @@ -112,6 +112,53 @@ "]" ] }, + { + "cell_type": "markdown", + "id": "3e3dc22c-7e03-46be-b6bc-e88a4e9e01e8", + "metadata": {}, + "source": [ + "This approach of interchangeable mappers is possible as they all provide a common `.suggest_mappings` method,\n", + "which in turn creates a common `LigandAtomMapping` object,\n", + "allowing tooling to mix and match which mapper they use." + ] + }, + { + "cell_type": "code", + "execution_count": 4, + "id": "9337f7e1-a25e-43a1-ba1f-cace9b7f5f00", + "metadata": {}, + "outputs": [ + { + "data": { + "text/plain": [ + "\u001b[0;31mSignature:\u001b[0m\n", + "\u001b[0mmappers\u001b[0m\u001b[0;34m[\u001b[0m\u001b[0;36m0\u001b[0m\u001b[0;34m]\u001b[0m\u001b[0;34m.\u001b[0m\u001b[0msuggest_mappings\u001b[0m\u001b[0;34m(\u001b[0m\u001b[0;34m\u001b[0m\n", + "\u001b[0;34m\u001b[0m \u001b[0mcomponentA\u001b[0m\u001b[0;34m:\u001b[0m \u001b[0mgufe\u001b[0m\u001b[0;34m.\u001b[0m\u001b[0mcomponents\u001b[0m\u001b[0;34m.\u001b[0m\u001b[0msmallmoleculecomponent\u001b[0m\u001b[0;34m.\u001b[0m\u001b[0mSmallMoleculeComponent\u001b[0m\u001b[0;34m,\u001b[0m\u001b[0;34m\u001b[0m\n", + "\u001b[0;34m\u001b[0m \u001b[0mcomponentB\u001b[0m\u001b[0;34m:\u001b[0m \u001b[0mgufe\u001b[0m\u001b[0;34m.\u001b[0m\u001b[0mcomponents\u001b[0m\u001b[0;34m.\u001b[0m\u001b[0msmallmoleculecomponent\u001b[0m\u001b[0;34m.\u001b[0m\u001b[0mSmallMoleculeComponent\u001b[0m\u001b[0;34m,\u001b[0m\u001b[0;34m\u001b[0m\n", + "\u001b[0;34m\u001b[0m\u001b[0;34m)\u001b[0m \u001b[0;34m->\u001b[0m \u001b[0mIterable\u001b[0m\u001b[0;34m[\u001b[0m\u001b[0mgufe\u001b[0m\u001b[0;34m.\u001b[0m\u001b[0mmapping\u001b[0m\u001b[0;34m.\u001b[0m\u001b[0mligandatommapping\u001b[0m\u001b[0;34m.\u001b[0m\u001b[0mLigandAtomMapping\u001b[0m\u001b[0;34m]\u001b[0m\u001b[0;34m\u001b[0m\u001b[0;34m\u001b[0m\u001b[0m\n", + "\u001b[0;31mDocstring:\u001b[0m\n", + "Generate one or more mappings between two small molecules\n", + "\n", + "Parameters\n", + "----------\n", + "componentA, componentB: gufe.SmallMoleculeComponent\n", + "\n", + "Returns\n", + "-------\n", + "mapping : Iterable[LigandAtomMapping]\n", + " potential mappings\n", + "\u001b[0;31mFile:\u001b[0m ~/miniconda3/envs/openfe_dev/lib/python3.11/site-packages/lomap/gufe_bindings/mapper.py\n", + "\u001b[0;31mType:\u001b[0m method" + ] + }, + "metadata": {}, + "output_type": "display_data" + } + ], + "source": [ + "?mappers[0].suggest_mappings" + ] + }, { "cell_type": "markdown", "id": "409a3866-a5ac-4295-b91f-3101dd646dc9", @@ -130,7 +177,7 @@ }, { "cell_type": "code", - "execution_count": 4, + "execution_count": 5, "id": "3bbf3f5b-9e29-467f-aff8-07e8dad7fd4c", "metadata": {}, "outputs": [], @@ -166,7 +213,7 @@ }, { "cell_type": "code", - "execution_count": 5, + "execution_count": 6, "id": "9492e2e7-33df-449e-9bd1-847ff52d2029", "metadata": {}, "outputs": [ @@ -261,18 +308,18 @@ }, { "cell_type": "code", - "execution_count": 6, + "execution_count": 7, "id": "92e0b934-8494-41f4-a0ad-0d0b01b3a8f9", "metadata": {}, "outputs": [ { "data": { - "image/png": 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", + "image/png": 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", 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" ] }, - "execution_count": 6, + "execution_count": 7, "metadata": {}, "output_type": "execute_result" } @@ -283,10 +330,20 @@ "plot_atommapping_network(ligand_network)" ] }, + { + "cell_type": "markdown", + "id": "1e5d7b45-8cd2-45f2-a38b-ede71d8c35f2", + "metadata": {}, + "source": [ + "## What next\n", + "\n", + "With a ligand network defined, a next logical step would be to choose and customise a free energy estimation method (in OpenFE parlance, a `Protocol`). This is applied to edges of the network to estimate the free energy differences of traversing this network." + ] + }, { "cell_type": "code", "execution_count": null, - "id": "7e7cb163-6bc6-4172-9170-dc9c778cc9d6", + "id": "a17eb44d-8b91-49a0-a00c-76cdfbf90ca8", "metadata": {}, "outputs": [], "source": [] @@ -308,7 +365,7 @@ "name": "python", "nbconvert_exporter": "python", "pygments_lexer": "ipython3", - "version": "3.11.8" + "version": "3.11.6" }, "widgets": { "application/vnd.jupyter.widget-state+json": {