diff --git a/src/CMakeLists.txt b/src/CMakeLists.txt
index 1c1427aa0..f69e0682a 100644
--- a/src/CMakeLists.txt
+++ b/src/CMakeLists.txt
@@ -33,6 +33,7 @@ set(ENABLE_PORTBLAS_BACKEND_NVIDIA_GPU OFF CACHE INTERNAL "")
 set(ONEMKL_GENERATED_INCLUDE_PATH ${CMAKE_CURRENT_BINARY_DIR})
 
 # Build loader and backends for each domain
+add_custom_target(onemkl_backend_libs)
 foreach(domain ${TARGET_DOMAINS})
   add_subdirectory(${domain})
 endforeach()
@@ -52,6 +53,12 @@ install(FILES "${CMAKE_CURRENT_BINARY_DIR}/oneapi/mkl/detail/config.hpp"
 if(BUILD_SHARED_LIBS)
   add_library(onemkl SHARED)
 
+  # The loader library depends on all the backend libraries as it uses
+  # dlopen to load them at runtime.
+  # Use add_dependencies to ensure that all the backend libraries are
+  # (re-)built when compiling the loader or runtime binaries.
+  add_dependencies(onemkl onemkl_backend_libs)
+
   target_include_directories(onemkl
     PUBLIC $<BUILD_INTERFACE:${PROJECT_SOURCE_DIR}/include>
            $<BUILD_INTERFACE:${CMAKE_CURRENT_BINARY_DIR}>
diff --git a/src/blas/backends/CMakeLists.txt b/src/blas/backends/CMakeLists.txt
index 1f0273a61..351f4b0e5 100644
--- a/src/blas/backends/CMakeLists.txt
+++ b/src/blas/backends/CMakeLists.txt
@@ -17,6 +17,9 @@
 # SPDX-License-Identifier: Apache-2.0
 #===============================================================================
 
+add_custom_target(onemkl_backend_libs_blas)
+add_dependencies(onemkl_backend_libs onemkl_backend_libs_blas)
+
 if(ENABLE_MKLCPU_BACKEND)
   add_subdirectory(mklcpu)
 endif()
diff --git a/src/blas/backends/cublas/CMakeLists.txt b/src/blas/backends/cublas/CMakeLists.txt
index 3cdf4a9d0..b64e7c37d 100644
--- a/src/blas/backends/cublas/CMakeLists.txt
+++ b/src/blas/backends/cublas/CMakeLists.txt
@@ -30,6 +30,7 @@ set(SOURCES cublas_level1.cpp
                 $<$<BOOL:${BUILD_SHARED_LIBS}>: cublas_wrappers.cpp>)
 add_library(${LIB_NAME})
 add_library(${LIB_OBJ} OBJECT ${SOURCES})
+add_dependencies(onemkl_backend_libs_blas ${LIB_NAME})
 
 target_include_directories(${LIB_OBJ}
   PRIVATE ${PROJECT_SOURCE_DIR}/include
diff --git a/src/blas/backends/mklcpu/CMakeLists.txt b/src/blas/backends/mklcpu/CMakeLists.txt
index 10201a3ac..322741d26 100644
--- a/src/blas/backends/mklcpu/CMakeLists.txt
+++ b/src/blas/backends/mklcpu/CMakeLists.txt
@@ -25,6 +25,7 @@ set(SOURCES
   $<$<BOOL:${BUILD_SHARED_LIBS}>: mklcpu_wrappers.cpp>)
 add_library(${LIB_NAME})
 add_library(${LIB_OBJ} OBJECT ${SOURCES})
+add_dependencies(onemkl_backend_libs_blas ${LIB_NAME})
 if (USE_ADD_SYCL_TO_TARGET_INTEGRATION)
   add_sycl_to_target(TARGET ${LIB_OBJ} SOURCES ${SOURCES})
 endif()
diff --git a/src/blas/backends/mklgpu/CMakeLists.txt b/src/blas/backends/mklgpu/CMakeLists.txt
index 32d2f0428..c971d1afd 100644
--- a/src/blas/backends/mklgpu/CMakeLists.txt
+++ b/src/blas/backends/mklgpu/CMakeLists.txt
@@ -25,6 +25,7 @@ add_library(${LIB_OBJ} OBJECT
   mklgpu_level1.cpp mklgpu_level2.cpp mklgpu_level3.cpp mklgpu_batch.cpp mklgpu_extensions.cpp
   $<$<BOOL:${BUILD_SHARED_LIBS}>: mklgpu_wrappers.cpp>
 )
+add_dependencies(onemkl_backend_libs_blas ${LIB_NAME})
 
 target_include_directories(${LIB_OBJ}
   PRIVATE ${PROJECT_SOURCE_DIR}/include
diff --git a/src/blas/backends/netlib/CMakeLists.txt b/src/blas/backends/netlib/CMakeLists.txt
index 195cb9cd9..fd5275fc0 100644
--- a/src/blas/backends/netlib/CMakeLists.txt
+++ b/src/blas/backends/netlib/CMakeLists.txt
@@ -29,7 +29,8 @@ set(SOURCES netlib_common.hpp
 )
 add_library(${LIB_NAME})
 add_library(${LIB_OBJ} OBJECT ${SOURCES})
-  
+add_dependencies(onemkl_backend_libs_blas ${LIB_NAME})
+
 if (USE_ADD_SYCL_TO_TARGET_INTEGRATION)
   add_sycl_to_target(TARGET ${LIB_OBJ} SOURCES ${SOURCES})
 endif()
diff --git a/src/blas/backends/portblas/CMakeLists.txt b/src/blas/backends/portblas/CMakeLists.txt
index f4356eed1..e1ad6862c 100644
--- a/src/blas/backends/portblas/CMakeLists.txt
+++ b/src/blas/backends/portblas/CMakeLists.txt
@@ -175,6 +175,7 @@ set(SOURCES
   $<$<BOOL:${BUILD_SHARED_LIBS}>: portblas_wrappers.cpp>)
 add_library(${LIB_NAME})
 add_library(${LIB_OBJ} OBJECT ${SOURCES})
+add_dependencies(onemkl_backend_libs_blas ${LIB_NAME})
 
 if (USE_ADD_SYCL_TO_TARGET_INTEGRATION)
   add_sycl_to_target(TARGET ${LIB_OBJ} SOURCES ${SOURCES})
diff --git a/src/blas/backends/rocblas/CMakeLists.txt b/src/blas/backends/rocblas/CMakeLists.txt
index 4d2cdf3bc..0d5559155 100644
--- a/src/blas/backends/rocblas/CMakeLists.txt
+++ b/src/blas/backends/rocblas/CMakeLists.txt
@@ -32,6 +32,7 @@ set(SOURCES rocblas_level1.cpp
                 $<$<BOOL:${BUILD_SHARED_LIBS}>: rocblas_wrappers.cpp>)
 add_library(${LIB_NAME})
 add_library(${LIB_OBJ} OBJECT ${SOURCES})
+add_dependencies(onemkl_backend_libs_blas ${LIB_NAME})
 
 target_include_directories(${LIB_OBJ}
   PRIVATE ${PROJECT_SOURCE_DIR}/include
diff --git a/src/dft/backends/CMakeLists.txt b/src/dft/backends/CMakeLists.txt
index 8f9b9939f..b03a63e8a 100644
--- a/src/dft/backends/CMakeLists.txt
+++ b/src/dft/backends/CMakeLists.txt
@@ -17,6 +17,9 @@
 # SPDX-License-Identifier: Apache-2.0
 #===============================================================================
 
+add_custom_target(onemkl_backend_libs_dft)
+add_dependencies(onemkl_backend_libs onemkl_backend_libs_dft)
+
 if(ENABLE_MKLGPU_BACKEND)
   add_subdirectory(mklgpu)
 endif()
diff --git a/src/dft/backends/cufft/CMakeLists.txt b/src/dft/backends/cufft/CMakeLists.txt
index 7586b1d5d..186b91aef 100644
--- a/src/dft/backends/cufft/CMakeLists.txt
+++ b/src/dft/backends/cufft/CMakeLists.txt
@@ -29,6 +29,7 @@ add_library(${LIB_OBJ} OBJECT
   backward.cpp
   $<$<BOOL:${BUILD_SHARED_LIBS}>: mkl_dft_cufft_wrappers.cpp>
 )
+add_dependencies(onemkl_backend_libs_dft ${LIB_NAME})
 
 target_include_directories(${LIB_OBJ}
   PRIVATE ${PROJECT_SOURCE_DIR}/include
diff --git a/src/dft/backends/mklcpu/CMakeLists.txt b/src/dft/backends/mklcpu/CMakeLists.txt
index ff21148a5..28fbdacfa 100644
--- a/src/dft/backends/mklcpu/CMakeLists.txt
+++ b/src/dft/backends/mklcpu/CMakeLists.txt
@@ -30,6 +30,7 @@ add_library(${LIB_OBJ} OBJECT
   backward.cpp
   $<$<BOOL:${BUILD_SHARED_LIBS}>: mkl_dft_cpu_wrappers.cpp>
 )
+add_dependencies(onemkl_backend_libs_dft ${LIB_NAME})
 
 target_include_directories(${LIB_OBJ}
   PRIVATE ${PROJECT_SOURCE_DIR}/include
diff --git a/src/dft/backends/mklgpu/CMakeLists.txt b/src/dft/backends/mklgpu/CMakeLists.txt
index 75e840683..e7b863ad3 100644
--- a/src/dft/backends/mklgpu/CMakeLists.txt
+++ b/src/dft/backends/mklgpu/CMakeLists.txt
@@ -30,6 +30,7 @@ add_library(${LIB_OBJ} OBJECT
   backward.cpp
   $<$<BOOL:${BUILD_SHARED_LIBS}>: mkl_dft_gpu_wrappers.cpp>
 )
+add_dependencies(onemkl_backend_libs_dft ${LIB_NAME})
 
 target_include_directories(${LIB_OBJ}
   PRIVATE ${PROJECT_SOURCE_DIR}/include
diff --git a/src/dft/backends/portfft/CMakeLists.txt b/src/dft/backends/portfft/CMakeLists.txt
index 3a0f7c237..6741875f2 100644
--- a/src/dft/backends/portfft/CMakeLists.txt
+++ b/src/dft/backends/portfft/CMakeLists.txt
@@ -62,6 +62,7 @@ add_library(${LIB_OBJ} OBJECT
   commit.cpp
   $<$<BOOL:${BUILD_SHARED_LIBS}>: mkl_dft_portfft_wrappers.cpp>
 )
+add_dependencies(onemkl_backend_libs_dft ${LIB_NAME})
 
 find_package(portfft QUIET)
 if (NOT portfft_FOUND)
diff --git a/src/dft/backends/rocfft/CMakeLists.txt b/src/dft/backends/rocfft/CMakeLists.txt
index 935db69c7..51c0ca177 100644
--- a/src/dft/backends/rocfft/CMakeLists.txt
+++ b/src/dft/backends/rocfft/CMakeLists.txt
@@ -29,6 +29,7 @@ add_library(${LIB_OBJ} OBJECT
   backward.cpp
   $<$<BOOL:${BUILD_SHARED_LIBS}>: mkl_dft_rocfft_wrappers.cpp>
 )
+add_dependencies(onemkl_backend_libs_dft ${LIB_NAME})
 
 target_include_directories(${LIB_OBJ}
   PRIVATE ${PROJECT_SOURCE_DIR}/include
diff --git a/src/lapack/backends/CMakeLists.txt b/src/lapack/backends/CMakeLists.txt
index 8085ba125..636f6728f 100644
--- a/src/lapack/backends/CMakeLists.txt
+++ b/src/lapack/backends/CMakeLists.txt
@@ -17,6 +17,9 @@
 # SPDX-License-Identifier: Apache-2.0
 #===============================================================================
 
+add_custom_target(onemkl_backend_libs_lapack)
+add_dependencies(onemkl_backend_libs onemkl_backend_libs_lapack)
+
 if(ENABLE_MKLCPU_BACKEND)
   add_subdirectory(mklcpu)
 endif()
diff --git a/src/lapack/backends/cusolver/CMakeLists.txt b/src/lapack/backends/cusolver/CMakeLists.txt
index 171380e59..dfd1267d7 100644
--- a/src/lapack/backends/cusolver/CMakeLists.txt
+++ b/src/lapack/backends/cusolver/CMakeLists.txt
@@ -27,6 +27,7 @@ set(SOURCES     cusolver_lapack.cpp
                 $<$<BOOL:${BUILD_SHARED_LIBS}>: cusolver_wrappers.cpp>)
 add_library(${LIB_NAME})
 add_library(${LIB_OBJ} OBJECT ${SOURCES})
+add_dependencies(onemkl_backend_libs_lapack ${LIB_NAME})
 
 target_include_directories(${LIB_OBJ}
   PRIVATE ${PROJECT_SOURCE_DIR}/include
diff --git a/src/lapack/backends/mklcpu/CMakeLists.txt b/src/lapack/backends/mklcpu/CMakeLists.txt
index 6eb22c4f5..fcc60a8e7 100644
--- a/src/lapack/backends/mklcpu/CMakeLists.txt
+++ b/src/lapack/backends/mklcpu/CMakeLists.txt
@@ -25,6 +25,7 @@ add_library(${LIB_OBJ} OBJECT
   mkl_lapack.cpp
   $<$<BOOL:${BUILD_SHARED_LIBS}>: lapack_cpu_wrappers.cpp>
 )
+add_dependencies(onemkl_backend_libs_lapack ${LIB_NAME})
 
 target_include_directories(${LIB_OBJ}
   PRIVATE ${PROJECT_SOURCE_DIR}/include
diff --git a/src/lapack/backends/mklgpu/CMakeLists.txt b/src/lapack/backends/mklgpu/CMakeLists.txt
index e5b52dc50..e11592f82 100644
--- a/src/lapack/backends/mklgpu/CMakeLists.txt
+++ b/src/lapack/backends/mklgpu/CMakeLists.txt
@@ -25,6 +25,7 @@ add_library(${LIB_OBJ} OBJECT
   mkl_lapack.cpp
   $<$<BOOL:${BUILD_SHARED_LIBS}>: lapack_gpu_wrappers.cpp>
 )
+add_dependencies(onemkl_backend_libs_lapack ${LIB_NAME})
 
 target_include_directories(${LIB_OBJ}
   PRIVATE ${PROJECT_SOURCE_DIR}/include
diff --git a/src/lapack/backends/rocsolver/CMakeLists.txt b/src/lapack/backends/rocsolver/CMakeLists.txt
index 34702a842..1162cca5b 100644
--- a/src/lapack/backends/rocsolver/CMakeLists.txt
+++ b/src/lapack/backends/rocsolver/CMakeLists.txt
@@ -28,6 +28,7 @@ set(SOURCES rocsolver_lapack.cpp
           $<$<BOOL:${BUILD_SHARED_LIBS}>: rocsolver_wrappers.cpp>)
 add_library(${LIB_NAME})
 add_library(${LIB_OBJ} OBJECT ${SOURCES})
+add_dependencies(onemkl_backend_libs_lapack ${LIB_NAME})
 
 target_include_directories(${LIB_OBJ}
   PRIVATE ${PROJECT_SOURCE_DIR}/include
diff --git a/src/rng/backends/CMakeLists.txt b/src/rng/backends/CMakeLists.txt
index 7324a6103..9045f7e75 100644
--- a/src/rng/backends/CMakeLists.txt
+++ b/src/rng/backends/CMakeLists.txt
@@ -17,6 +17,9 @@
 # SPDX-License-Identifier: Apache-2.0
 #===============================================================================
 
+add_custom_target(onemkl_backend_libs_rng)
+add_dependencies(onemkl_backend_libs onemkl_backend_libs_rng)
+
 if(ENABLE_MKLCPU_BACKEND)
   add_subdirectory(mklcpu)
 endif()
diff --git a/src/rng/backends/curand/CMakeLists.txt b/src/rng/backends/curand/CMakeLists.txt
index 57f42bd0c..f37a34f1d 100644
--- a/src/rng/backends/curand/CMakeLists.txt
+++ b/src/rng/backends/curand/CMakeLists.txt
@@ -66,6 +66,7 @@ set(SOURCES philox4x32x10.cpp
 
 add_library(${LIB_NAME})
 add_library(${LIB_OBJ} OBJECT ${SOURCES})
+add_dependencies(onemkl_backend_libs_rng ${LIB_NAME})
 
 target_include_directories(${LIB_OBJ}
   PRIVATE ${PROJECT_SOURCE_DIR}/include
diff --git a/src/rng/backends/mklcpu/CMakeLists.txt b/src/rng/backends/mklcpu/CMakeLists.txt
index 2c6d1ef01..e72ce048f 100644
--- a/src/rng/backends/mklcpu/CMakeLists.txt
+++ b/src/rng/backends/mklcpu/CMakeLists.txt
@@ -28,6 +28,7 @@ set(SOURCES cpu_common.hpp
 
 add_library(${LIB_NAME})
 add_library(${LIB_OBJ} OBJECT ${SOURCES})
+add_dependencies(onemkl_backend_libs_rng ${LIB_NAME})
 target_include_directories(${LIB_OBJ}
   PRIVATE ${PROJECT_SOURCE_DIR}/include
           ${PROJECT_SOURCE_DIR}/src
diff --git a/src/rng/backends/mklgpu/CMakeLists.txt b/src/rng/backends/mklgpu/CMakeLists.txt
index 1d268f9cb..150f90136 100644
--- a/src/rng/backends/mklgpu/CMakeLists.txt
+++ b/src/rng/backends/mklgpu/CMakeLists.txt
@@ -27,6 +27,7 @@ add_library(${LIB_OBJ} OBJECT
   mrg32k3a.cpp
   $<$<BOOL:${BUILD_SHARED_LIBS}>: mkl_rng_gpu_wrappers.cpp>
 )
+add_dependencies(onemkl_backend_libs_rng ${LIB_NAME})
 
 target_include_directories(${LIB_OBJ}
   PRIVATE ${PROJECT_SOURCE_DIR}/include
diff --git a/src/rng/backends/rocrand/CMakeLists.txt b/src/rng/backends/rocrand/CMakeLists.txt
index 13ffc5e82..b3c1d04bd 100644
--- a/src/rng/backends/rocrand/CMakeLists.txt
+++ b/src/rng/backends/rocrand/CMakeLists.txt
@@ -61,6 +61,7 @@ set(SOURCES philox4x32x10.cpp mrg32k3a.cpp $<$<BOOL:${BUILD_SHARED_LIBS}>:
 
 add_library(${LIB_NAME})
 add_library(${LIB_OBJ} OBJECT ${SOURCES})
+add_dependencies(onemkl_backend_libs_rng ${LIB_NAME})
 
 target_include_directories(
   ${LIB_OBJ} PRIVATE ${PROJECT_SOURCE_DIR}/include ${PROJECT_SOURCE_DIR}/src
diff --git a/src/sparse_blas/backends/CMakeLists.txt b/src/sparse_blas/backends/CMakeLists.txt
index aafb48851..ef606c6e1 100644
--- a/src/sparse_blas/backends/CMakeLists.txt
+++ b/src/sparse_blas/backends/CMakeLists.txt
@@ -17,6 +17,9 @@
 # SPDX-License-Identifier: Apache-2.0
 #===============================================================================
 
+add_custom_target(onemkl_backend_libs_sparse_blas)
+add_dependencies(onemkl_backend_libs onemkl_backend_libs_sparse_blas)
+
 if(ENABLE_MKLCPU_BACKEND)
   add_subdirectory(mklcpu)
 endif()
diff --git a/src/sparse_blas/backends/mklcpu/CMakeLists.txt b/src/sparse_blas/backends/mklcpu/CMakeLists.txt
index fb243c2f8..cfcf9cf3d 100644
--- a/src/sparse_blas/backends/mklcpu/CMakeLists.txt
+++ b/src/sparse_blas/backends/mklcpu/CMakeLists.txt
@@ -28,6 +28,7 @@ add_library(${LIB_OBJ} OBJECT
   mklcpu_operations.cpp
   $<$<BOOL:${BUILD_SHARED_LIBS}>: mklcpu_wrappers.cpp>
 )
+add_dependencies(onemkl_backend_libs_sparse_blas ${LIB_NAME})
 
 target_include_directories(${LIB_OBJ}
   PRIVATE ${PROJECT_SOURCE_DIR}/include
diff --git a/src/sparse_blas/backends/mklgpu/CMakeLists.txt b/src/sparse_blas/backends/mklgpu/CMakeLists.txt
index 67c129c15..a31794547 100644
--- a/src/sparse_blas/backends/mklgpu/CMakeLists.txt
+++ b/src/sparse_blas/backends/mklgpu/CMakeLists.txt
@@ -28,6 +28,7 @@ add_library(${LIB_OBJ} OBJECT
   mklgpu_operations.cpp
   $<$<BOOL:${BUILD_SHARED_LIBS}>: mklgpu_wrappers.cpp>
 )
+add_dependencies(onemkl_backend_libs_sparse_blas ${LIB_NAME})
 
 target_include_directories(${LIB_OBJ}
   PRIVATE ${PROJECT_SOURCE_DIR}/include