+
Also known as
-
{{ gene.ensembl_gene_id }}
-
+
+
+ {{ gene.ensembl_gene_id }}
+
+ (Ensembl Release {{ gene.ensembl_info[0].ensembl_release }})
+
+
+
+
+ {{ gene.ensembl_gene_id }}
+
+
+ Possible replacement values:
+ {{ gene.ensembl_info[0].ensembl_possible_replacements.join(', ')}}
+
+
{{ getAlias() }}
diff --git a/src/app/features/genes/components/gene-hero/gene-hero.component.scss b/src/app/features/genes/components/gene-hero/gene-hero.component.scss
index 57f98b79..f2c8c354 100644
--- a/src/app/features/genes/components/gene-hero/gene-hero.component.scss
+++ b/src/app/features/genes/components/gene-hero/gene-hero.component.scss
@@ -53,3 +53,7 @@ hr {
text-transform: uppercase;
margin-bottom: 15px;
}
+
+.possible-replacements {
+ margin-bottom: 15px;
+}
\ No newline at end of file
diff --git a/src/app/features/genes/components/gene-hero/gene-hero.component.spec.ts b/src/app/features/genes/components/gene-hero/gene-hero.component.spec.ts
index d732b85f..f47342de 100644
--- a/src/app/features/genes/components/gene-hero/gene-hero.component.spec.ts
+++ b/src/app/features/genes/components/gene-hero/gene-hero.component.spec.ts
@@ -8,7 +8,7 @@ import { RouterTestingModule } from '@angular/router/testing';
// Internal
// -------------------------------------------------------------------------- //
import { GeneHeroComponent } from './';
-import { geneMock1, geneMock3 } from '../../../../testing';
+import { geneMissingEnsemblInfo, geneMock1, geneMock3 } from '../../../../testing';
// -------------------------------------------------------------------------- //
// Tests
@@ -110,4 +110,20 @@ describe('Component: Gene Hero', () => {
const expected = 'Immune Response, Lipid Metabolism, Structural Stabilization, Synapse, Vasculature';
expect(component.getBiodomains()).toBe(expected);
});
+
+ it('should return the ensembl permalink', () => {
+ component.gene = geneMock1;
+ expect(component.getEnsemblUrl()).toBe('https://may2015.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000264794');
+ });
+
+ it('should return an empty string if the gene is missing ensembl info', () => {
+ // if gene does not have a url
+ component.gene = geneMissingEnsemblInfo;
+ expect(component.getEnsemblUrl()).toBe('');
+ });
+
+ it('should return a url with ensembl id', () => {
+ component.gene = geneMock1;
+ expect(component.getPossibleReplacementsURL()).toBe('https://useast.ensembl.org/Homo_sapiens/Gene/Idhistory?g=ENSG00000147065');
+ });
});
diff --git a/src/app/features/genes/components/gene-hero/gene-hero.component.ts b/src/app/features/genes/components/gene-hero/gene-hero.component.ts
index 07a7d389..56c0e735 100644
--- a/src/app/features/genes/components/gene-hero/gene-hero.component.ts
+++ b/src/app/features/genes/components/gene-hero/gene-hero.component.ts
@@ -101,4 +101,15 @@ export class GeneHeroComponent {
.sort(ascending);
return biodomains.join(', ');
}
+
+ getEnsemblUrl() {
+ if (!this.gene?.ensembl_info || this.gene.ensembl_info.length <= 0)
+ return '';
+ return this.gene?.ensembl_info[0].ensembl_permalink;
+ }
+
+ getPossibleReplacementsURL() {
+ let url = 'https://useast.ensembl.org/Homo_sapiens/Gene/Idhistory?g=';
+ return url += this.gene?.ensembl_gene_id;
+ }
}
diff --git a/src/app/models/EnsemblInfo.ts b/src/app/models/EnsemblInfo.ts
new file mode 100644
index 00000000..a1b08a2e
--- /dev/null
+++ b/src/app/models/EnsemblInfo.ts
@@ -0,0 +1,5 @@
+export interface EnsemblInfo {
+ ensembl_release: number;
+ ensembl_possible_replacements: string[];
+ ensembl_permalink: string;
+}
\ No newline at end of file
diff --git a/src/app/models/genes.ts b/src/app/models/genes.ts
index f979fc0d..acb5320a 100644
--- a/src/app/models/genes.ts
+++ b/src/app/models/genes.ts
@@ -8,6 +8,7 @@ import {
SimilarGenesNetwork,
BioDomains
} from './';
+import { EnsemblInfo } from './EnsemblInfo';
export interface TargetNomination {
source: string;
@@ -98,6 +99,9 @@ export interface Gene {
input_data_display_value?: string;
bio_domains?: BioDomains;
+
+ // FIXME Will be fixed by AG-1324 in a future data release as it doesn't make sense to have an array here
+ ensembl_info: EnsemblInfo[];
}
export interface GenesResponse {
diff --git a/src/app/testing/gene-mocks.ts b/src/app/testing/gene-mocks.ts
index f744697e..08e2ccb0 100644
--- a/src/app/testing/gene-mocks.ts
+++ b/src/app/testing/gene-mocks.ts
@@ -2,6 +2,1007 @@
import { Gene, GCTGene } from '../models';
+export const geneMissingEnsemblInfo: Gene = {
+ _id: '628ea1be0e8d04279fdbaa26',
+ ensembl_gene_id: 'ENSG00000147065',
+ name: 'moesin',
+ summary:
+ 'Moesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement. [provided by RefSeq, Jul 2008].',
+ hgnc_symbol: 'MSN',
+ alias: ['HEL70', 'IMD50'],
+ is_igap: false,
+ is_eqtl: false,
+ is_any_rna_changed_in_ad_brain: true,
+ rna_brain_change_studied: true,
+ is_any_protein_changed_in_ad_brain: true,
+ protein_brain_change_studied: true,
+ target_nominations: [],
+ median_expression: [],
+ druggability: [],
+ total_nominations: 5,
+ rna_differential_expression: [],
+ proteomics_LFQ: [],
+ proteomics_TMT: [],
+ metabolomics: '',
+ neuropathologic_correlations: [],
+ overall_scores: {
+ ensembl_gene_id: 'ENSG00000147065',
+ target_risk_score: 3.27647279338428,
+ genetics_score: 0.36140442487816,
+ multi_omics_score: 1.99912990696766,
+ literature_score: 0.915938461538462,
+ },
+ experimental_validation: [],
+ links: [],
+ similar_genes_network: {
+ nodes: [
+ {
+ ensembl_gene_id: 'ENSG00000147065',
+ hgnc_symbol: 'MSN',
+ brain_regions: ['CBE', 'DLPFC', 'FP', 'IFG', 'PHG', 'STG', 'TCX'],
+ },
+ {
+ ensembl_gene_id: 'ENSG00000135046',
+ hgnc_symbol: 'ANXA1',
+ brain_regions: ['CBE', 'DLPFC', 'FP', 'IFG', 'PHG', 'STG', 'TCX'],
+ },
+ {
+ ensembl_gene_id: 'ENSG00000137285',
+ hgnc_symbol: 'TUBB2B',
+ brain_regions: ['CBE', 'DLPFC', 'FP', 'IFG', 'PHG', 'STG', 'TCX'],
+ },
+ {
+ ensembl_gene_id: 'ENSG00000117519',
+ hgnc_symbol: 'CNN3',
+ brain_regions: ['CBE', 'DLPFC', 'FP', 'IFG', 'PHG', 'STG', 'TCX'],
+ },
+ {
+ ensembl_gene_id: 'ENSG00000111348',
+ hgnc_symbol: 'ARHGDIB',
+ brain_regions: ['CBE', 'DLPFC', 'FP', 'IFG', 'PHG', 'STG', 'TCX'],
+ },
+ {
+ ensembl_gene_id: 'ENSG00000163191',
+ hgnc_symbol: 'S100A11',
+ brain_regions: ['CBE', 'DLPFC', 'FP', 'IFG', 'PHG', 'STG', 'TCX'],
+ },
+ {
+ ensembl_gene_id: 'ENSG00000196924',
+ hgnc_symbol: 'FLNA',
+ brain_regions: ['CBE', 'DLPFC', 'FP', 'IFG', 'PHG', 'STG', 'TCX'],
+ },
+ {
+ ensembl_gene_id: 'ENSG00000155366',
+ hgnc_symbol: 'RHOC',
+ brain_regions: ['CBE', 'DLPFC', 'FP', 'PHG', 'STG', 'TCX'],
+ },
+ {
+ ensembl_gene_id: 'ENSG00000174021',
+ hgnc_symbol: 'GNG5',
+ brain_regions: ['CBE', 'DLPFC', 'FP', 'IFG', 'PHG'],
+ },
+ {
+ ensembl_gene_id: 'ENSG00000134531',
+ hgnc_symbol: 'EMP1',
+ brain_regions: ['DLPFC', 'FP', 'PHG', 'STG', 'TCX'],
+ },
+ {
+ ensembl_gene_id: 'ENSG00000101160',
+ hgnc_symbol: 'CTSZ',
+ brain_regions: ['DLPFC', 'FP', 'IFG', 'PHG', 'TCX'],
+ },
+ {
+ ensembl_gene_id: 'ENSG00000134871',
+ hgnc_symbol: 'COL4A2',
+ brain_regions: ['DLPFC', 'FP', 'IFG', 'PHG', 'TCX'],
+ },
+ {
+ ensembl_gene_id: 'ENSG00000111321',
+ hgnc_symbol: 'LTBR',
+ brain_regions: ['CBE', 'DLPFC', 'FP', 'PHG', 'TCX'],
+ },
+ {
+ ensembl_gene_id: 'ENSG00000119408',
+ hgnc_symbol: 'NEK6',
+ brain_regions: ['CBE', 'DLPFC', 'FP', 'PHG', 'TCX'],
+ },
+ {
+ ensembl_gene_id: 'ENSG00000102265',
+ hgnc_symbol: 'TIMP1',
+ brain_regions: ['CBE', 'DLPFC', 'IFG', 'STG', 'TCX'],
+ },
+ {
+ ensembl_gene_id: 'ENSG00000087086',
+ hgnc_symbol: 'FTL',
+ brain_regions: ['CBE', 'DLPFC', 'FP', 'PHG'],
+ },
+ {
+ ensembl_gene_id: 'ENSG00000168610',
+ hgnc_symbol: 'STAT3',
+ brain_regions: ['CBE', 'FP', 'PHG', 'TCX'],
+ },
+ {
+ ensembl_gene_id: 'ENSG00000177119',
+ hgnc_symbol: 'ANO6',
+ brain_regions: ['DLPFC', 'FP', 'IFG', 'STG'],
+ },
+ {
+ ensembl_gene_id: 'ENSG00000135363',
+ hgnc_symbol: 'LMO2',
+ brain_regions: ['DLPFC', 'FP', 'IFG', 'PHG'],
+ },
+ {
+ ensembl_gene_id: 'ENSG00000018408',
+ hgnc_symbol: 'WWTR1',
+ brain_regions: ['DLPFC', 'FP', 'PHG', 'TCX'],
+ },
+ {
+ ensembl_gene_id: 'ENSG00000170989',
+ hgnc_symbol: 'S1PR1',
+ brain_regions: ['CBE', 'DLPFC', 'IFG', 'TCX'],
+ },
+ {
+ ensembl_gene_id: 'ENSG00000141510',
+ hgnc_symbol: 'TP53',
+ brain_regions: ['DLPFC', 'FP', 'PHG', 'TCX'],
+ },
+ {
+ ensembl_gene_id: 'ENSG00000168899',
+ hgnc_symbol: 'VAMP5',
+ brain_regions: ['CBE', 'DLPFC', 'PHG', 'TCX'],
+ },
+ {
+ ensembl_gene_id: 'ENSG00000117226',
+ hgnc_symbol: 'GBP3',
+ brain_regions: ['FP', 'IFG', 'PHG'],
+ },
+ {
+ ensembl_gene_id: 'ENSG00000132561',
+ hgnc_symbol: 'MATN2',
+ brain_regions: ['CBE', 'DLPFC', 'IFG'],
+ },
+ {
+ ensembl_gene_id: 'ENSG00000113140',
+ hgnc_symbol: 'SPARC',
+ brain_regions: ['CBE', 'STG', 'TCX'],
+ },
+ {
+ ensembl_gene_id: 'ENSG00000111145',
+ hgnc_symbol: 'ELK3',
+ brain_regions: ['DLPFC', 'IFG', 'STG'],
+ },
+ {
+ ensembl_gene_id: 'ENSG00000120278',
+ hgnc_symbol: 'PLEKHG1',
+ brain_regions: ['DLPFC', 'IFG', 'TCX'],
+ },
+ {
+ ensembl_gene_id: 'ENSG00000132688',
+ hgnc_symbol: 'NES',
+ brain_regions: ['DLPFC', 'IFG', 'PHG'],
+ },
+ {
+ ensembl_gene_id: 'ENSG00000166340',
+ hgnc_symbol: 'TPP1',
+ brain_regions: ['CBE', 'DLPFC'],
+ },
+ {
+ ensembl_gene_id: 'ENSG00000168309',
+ hgnc_symbol: 'FAM107A',
+ brain_regions: ['CBE', 'PHG'],
+ },
+ {
+ ensembl_gene_id: 'ENSG00000172164',
+ hgnc_symbol: 'SNTB1',
+ brain_regions: ['CBE', 'TCX'],
+ },
+ {
+ ensembl_gene_id: 'ENSG00000169504',
+ hgnc_symbol: 'CLIC4',
+ brain_regions: ['DLPFC', 'FP'],
+ },
+ {
+ ensembl_gene_id: 'ENSG00000131724',
+ hgnc_symbol: 'IL13RA1',
+ brain_regions: ['FP', 'TCX'],
+ },
+ {
+ ensembl_gene_id: 'ENSG00000136754',
+ hgnc_symbol: 'ABI1',
+ brain_regions: ['CBE'],
+ },
+ {
+ ensembl_gene_id: 'ENSG00000078295',
+ hgnc_symbol: 'ADCY2',
+ brain_regions: ['CBE'],
+ },
+ ],
+ links: [
+ {
+ source: 'ENSG00000147065',
+ target: 'ENSG00000196924',
+ source_hgnc_symbol: 'MSN',
+ target_hgnc_symbol: 'FLNA',
+ brain_regions: ['CBE', 'DLPFC', 'FP', 'IFG', 'PHG', 'STG', 'TCX'],
+ },
+ {
+ source: 'ENSG00000147065',
+ target: 'ENSG00000131724',
+ source_hgnc_symbol: 'MSN',
+ target_hgnc_symbol: 'IL13RA1',
+ brain_regions: ['FP', 'TCX'],
+ },
+ {
+ source: 'ENSG00000147065',
+ target: 'ENSG00000163191',
+ source_hgnc_symbol: 'MSN',
+ target_hgnc_symbol: 'S100A11',
+ brain_regions: ['CBE', 'DLPFC', 'FP', 'IFG', 'PHG', 'STG', 'TCX'],
+ },
+ {
+ source: 'ENSG00000169504',
+ target: 'ENSG00000147065',
+ source_hgnc_symbol: 'CLIC4',
+ target_hgnc_symbol: 'MSN',
+ brain_regions: ['DLPFC', 'FP'],
+ },
+ {
+ source: 'ENSG00000155366',
+ target: 'ENSG00000147065',
+ source_hgnc_symbol: 'RHOC',
+ target_hgnc_symbol: 'MSN',
+ brain_regions: ['CBE', 'DLPFC', 'FP', 'PHG', 'STG', 'TCX'],
+ },
+ {
+ source: 'ENSG00000132688',
+ target: 'ENSG00000147065',
+ source_hgnc_symbol: 'NES',
+ target_hgnc_symbol: 'MSN',
+ brain_regions: ['DLPFC', 'IFG', 'PHG'],
+ },
+ {
+ source: 'ENSG00000168899',
+ target: 'ENSG00000147065',
+ source_hgnc_symbol: 'VAMP5',
+ target_hgnc_symbol: 'MSN',
+ brain_regions: ['CBE', 'DLPFC', 'PHG', 'TCX'],
+ },
+ {
+ source: 'ENSG00000120278',
+ target: 'ENSG00000147065',
+ source_hgnc_symbol: 'PLEKHG1',
+ target_hgnc_symbol: 'MSN',
+ brain_regions: ['DLPFC', 'IFG', 'TCX'],
+ },
+ {
+ source: 'ENSG00000111348',
+ target: 'ENSG00000147065',
+ source_hgnc_symbol: 'ARHGDIB',
+ target_hgnc_symbol: 'MSN',
+ brain_regions: ['CBE', 'DLPFC', 'FP', 'IFG', 'PHG', 'STG', 'TCX'],
+ },
+ {
+ source: 'ENSG00000111145',
+ target: 'ENSG00000147065',
+ source_hgnc_symbol: 'ELK3',
+ target_hgnc_symbol: 'MSN',
+ brain_regions: ['DLPFC', 'IFG', 'STG'],
+ },
+ {
+ source: 'ENSG00000102265',
+ target: 'ENSG00000147065',
+ source_hgnc_symbol: 'TIMP1',
+ target_hgnc_symbol: 'MSN',
+ brain_regions: ['CBE', 'DLPFC', 'IFG', 'STG', 'TCX'],
+ },
+ {
+ source: 'ENSG00000172164',
+ target: 'ENSG00000147065',
+ source_hgnc_symbol: 'SNTB1',
+ target_hgnc_symbol: 'MSN',
+ brain_regions: ['CBE', 'TCX'],
+ },
+ {
+ source: 'ENSG00000141510',
+ target: 'ENSG00000147065',
+ source_hgnc_symbol: 'TP53',
+ target_hgnc_symbol: 'MSN',
+ brain_regions: ['DLPFC', 'FP', 'PHG', 'TCX'],
+ },
+ {
+ source: 'ENSG00000117519',
+ target: 'ENSG00000147065',
+ source_hgnc_symbol: 'CNN3',
+ target_hgnc_symbol: 'MSN',
+ brain_regions: ['CBE', 'DLPFC', 'FP', 'IFG', 'PHG', 'STG', 'TCX'],
+ },
+ {
+ source: 'ENSG00000170989',
+ target: 'ENSG00000147065',
+ source_hgnc_symbol: 'S1PR1',
+ target_hgnc_symbol: 'MSN',
+ brain_regions: ['CBE', 'DLPFC', 'IFG', 'TCX'],
+ },
+ {
+ source: 'ENSG00000168309',
+ target: 'ENSG00000147065',
+ source_hgnc_symbol: 'FAM107A',
+ target_hgnc_symbol: 'MSN',
+ brain_regions: ['CBE', 'PHG'],
+ },
+ {
+ source: 'ENSG00000078295',
+ target: 'ENSG00000147065',
+ source_hgnc_symbol: 'ADCY2',
+ target_hgnc_symbol: 'MSN',
+ brain_regions: ['CBE'],
+ },
+ {
+ source: 'ENSG00000113140',
+ target: 'ENSG00000147065',
+ source_hgnc_symbol: 'SPARC',
+ target_hgnc_symbol: 'MSN',
+ brain_regions: ['CBE', 'STG', 'TCX'],
+ },
+ {
+ source: 'ENSG00000137285',
+ target: 'ENSG00000147065',
+ source_hgnc_symbol: 'TUBB2B',
+ target_hgnc_symbol: 'MSN',
+ brain_regions: ['CBE', 'DLPFC', 'FP', 'IFG', 'PHG', 'STG', 'TCX'],
+ },
+ {
+ source: 'ENSG00000132561',
+ target: 'ENSG00000147065',
+ source_hgnc_symbol: 'MATN2',
+ target_hgnc_symbol: 'MSN',
+ brain_regions: ['CBE', 'DLPFC', 'IFG'],
+ },
+ {
+ source: 'ENSG00000136754',
+ target: 'ENSG00000147065',
+ source_hgnc_symbol: 'ABI1',
+ target_hgnc_symbol: 'MSN',
+ brain_regions: ['CBE'],
+ },
+ {
+ source: 'ENSG00000166340',
+ target: 'ENSG00000147065',
+ source_hgnc_symbol: 'TPP1',
+ target_hgnc_symbol: 'MSN',
+ brain_regions: ['CBE', 'DLPFC'],
+ },
+ {
+ source: 'ENSG00000117226',
+ target: 'ENSG00000147065',
+ source_hgnc_symbol: 'GBP3',
+ target_hgnc_symbol: 'MSN',
+ brain_regions: ['FP', 'IFG', 'PHG'],
+ },
+ {
+ source: 'ENSG00000018408',
+ target: 'ENSG00000147065',
+ source_hgnc_symbol: 'WWTR1',
+ target_hgnc_symbol: 'MSN',
+ brain_regions: ['DLPFC', 'FP', 'PHG', 'TCX'],
+ },
+ {
+ source: 'ENSG00000119408',
+ target: 'ENSG00000147065',
+ source_hgnc_symbol: 'NEK6',
+ target_hgnc_symbol: 'MSN',
+ brain_regions: ['CBE', 'DLPFC', 'FP', 'PHG', 'TCX'],
+ },
+ {
+ source: 'ENSG00000135363',
+ target: 'ENSG00000147065',
+ source_hgnc_symbol: 'LMO2',
+ target_hgnc_symbol: 'MSN',
+ brain_regions: ['DLPFC', 'FP', 'IFG', 'PHG'],
+ },
+ {
+ source: 'ENSG00000111321',
+ target: 'ENSG00000147065',
+ source_hgnc_symbol: 'LTBR',
+ target_hgnc_symbol: 'MSN',
+ brain_regions: ['CBE', 'DLPFC', 'FP', 'PHG', 'TCX'],
+ },
+ {
+ source: 'ENSG00000177119',
+ target: 'ENSG00000147065',
+ source_hgnc_symbol: 'ANO6',
+ target_hgnc_symbol: 'MSN',
+ brain_regions: ['DLPFC', 'FP', 'IFG', 'STG'],
+ },
+ {
+ source: 'ENSG00000134871',
+ target: 'ENSG00000147065',
+ source_hgnc_symbol: 'COL4A2',
+ target_hgnc_symbol: 'MSN',
+ brain_regions: ['DLPFC', 'FP', 'IFG', 'PHG', 'TCX'],
+ },
+ {
+ source: 'ENSG00000168610',
+ target: 'ENSG00000147065',
+ source_hgnc_symbol: 'STAT3',
+ target_hgnc_symbol: 'MSN',
+ brain_regions: ['CBE', 'FP', 'PHG', 'TCX'],
+ },
+ {
+ source: 'ENSG00000087086',
+ target: 'ENSG00000147065',
+ source_hgnc_symbol: 'FTL',
+ target_hgnc_symbol: 'MSN',
+ brain_regions: ['CBE', 'DLPFC', 'FP', 'PHG'],
+ },
+ {
+ source: 'ENSG00000101160',
+ target: 'ENSG00000147065',
+ source_hgnc_symbol: 'CTSZ',
+ target_hgnc_symbol: 'MSN',
+ brain_regions: ['DLPFC', 'FP', 'IFG', 'PHG', 'TCX'],
+ },
+ {
+ source: 'ENSG00000018408',
+ target: 'ENSG00000177119',
+ source_hgnc_symbol: 'WWTR1',
+ target_hgnc_symbol: 'ANO6',
+ brain_regions: ['DLPFC'],
+ },
+ {
+ source: 'ENSG00000018408',
+ target: 'ENSG00000111145',
+ source_hgnc_symbol: 'WWTR1',
+ target_hgnc_symbol: 'ELK3',
+ brain_regions: ['DLPFC'],
+ },
+ {
+ source: 'ENSG00000018408',
+ target: 'ENSG00000113140',
+ source_hgnc_symbol: 'WWTR1',
+ target_hgnc_symbol: 'SPARC',
+ brain_regions: ['TCX'],
+ },
+ {
+ source: 'ENSG00000018408',
+ target: 'ENSG00000135046',
+ source_hgnc_symbol: 'WWTR1',
+ target_hgnc_symbol: 'ANXA1',
+ brain_regions: ['CBE', 'DLPFC', 'FP', 'IFG', 'PHG', 'STG', 'TCX'],
+ },
+ {
+ source: 'ENSG00000018408',
+ target: 'ENSG00000119408',
+ source_hgnc_symbol: 'WWTR1',
+ target_hgnc_symbol: 'NEK6',
+ brain_regions: ['FP'],
+ },
+ {
+ source: 'ENSG00000087086',
+ target: 'ENSG00000196924',
+ source_hgnc_symbol: 'FTL',
+ target_hgnc_symbol: 'FLNA',
+ brain_regions: ['DLPFC'],
+ },
+ {
+ source: 'ENSG00000101160',
+ target: 'ENSG00000163191',
+ source_hgnc_symbol: 'CTSZ',
+ target_hgnc_symbol: 'S100A11',
+ brain_regions: ['PHG'],
+ },
+ {
+ source: 'ENSG00000102265',
+ target: 'ENSG00000196924',
+ source_hgnc_symbol: 'TIMP1',
+ target_hgnc_symbol: 'FLNA',
+ brain_regions: ['TCX'],
+ },
+ {
+ source: 'ENSG00000111321',
+ target: 'ENSG00000168610',
+ source_hgnc_symbol: 'LTBR',
+ target_hgnc_symbol: 'STAT3',
+ brain_regions: ['CBE'],
+ },
+ {
+ source: 'ENSG00000111321',
+ target: 'ENSG00000101160',
+ source_hgnc_symbol: 'LTBR',
+ target_hgnc_symbol: 'CTSZ',
+ brain_regions: ['PHG'],
+ },
+ {
+ source: 'ENSG00000111348',
+ target: 'ENSG00000131724',
+ source_hgnc_symbol: 'ARHGDIB',
+ target_hgnc_symbol: 'IL13RA1',
+ brain_regions: ['FP'],
+ },
+ {
+ source: 'ENSG00000113140',
+ target: 'ENSG00000172164',
+ source_hgnc_symbol: 'SPARC',
+ target_hgnc_symbol: 'SNTB1',
+ brain_regions: ['TCX'],
+ },
+ {
+ source: 'ENSG00000113140',
+ target: 'ENSG00000111145',
+ source_hgnc_symbol: 'SPARC',
+ target_hgnc_symbol: 'ELK3',
+ brain_regions: ['STG'],
+ },
+ {
+ source: 'ENSG00000117519',
+ target: 'ENSG00000141510',
+ source_hgnc_symbol: 'CNN3',
+ target_hgnc_symbol: 'TP53',
+ brain_regions: ['DLPFC'],
+ },
+ {
+ source: 'ENSG00000117519',
+ target: 'ENSG00000196924',
+ source_hgnc_symbol: 'CNN3',
+ target_hgnc_symbol: 'FLNA',
+ brain_regions: ['DLPFC'],
+ },
+ {
+ source: 'ENSG00000117519',
+ target: 'ENSG00000018408',
+ source_hgnc_symbol: 'CNN3',
+ target_hgnc_symbol: 'WWTR1',
+ brain_regions: ['FP'],
+ },
+ {
+ source: 'ENSG00000117519',
+ target: 'ENSG00000177119',
+ source_hgnc_symbol: 'CNN3',
+ target_hgnc_symbol: 'ANO6',
+ brain_regions: ['FP'],
+ },
+ {
+ source: 'ENSG00000117519',
+ target: 'ENSG00000134531',
+ source_hgnc_symbol: 'CNN3',
+ target_hgnc_symbol: 'EMP1',
+ brain_regions: ['DLPFC', 'FP', 'PHG', 'STG', 'TCX'],
+ },
+ {
+ source: 'ENSG00000120278',
+ target: 'ENSG00000134531',
+ source_hgnc_symbol: 'PLEKHG1',
+ target_hgnc_symbol: 'EMP1',
+ brain_regions: ['DLPFC'],
+ },
+ {
+ source: 'ENSG00000132561',
+ target: 'ENSG00000177119',
+ source_hgnc_symbol: 'MATN2',
+ target_hgnc_symbol: 'ANO6',
+ brain_regions: ['IFG'],
+ },
+ {
+ source: 'ENSG00000132688',
+ target: 'ENSG00000196924',
+ source_hgnc_symbol: 'NES',
+ target_hgnc_symbol: 'FLNA',
+ brain_regions: ['DLPFC'],
+ },
+ {
+ source: 'ENSG00000132688',
+ target: 'ENSG00000018408',
+ source_hgnc_symbol: 'NES',
+ target_hgnc_symbol: 'WWTR1',
+ brain_regions: ['PHG'],
+ },
+ {
+ source: 'ENSG00000132688',
+ target: 'ENSG00000135046',
+ source_hgnc_symbol: 'NES',
+ target_hgnc_symbol: 'ANXA1',
+ brain_regions: ['IFG'],
+ },
+ {
+ source: 'ENSG00000134531',
+ target: 'ENSG00000177119',
+ source_hgnc_symbol: 'EMP1',
+ target_hgnc_symbol: 'ANO6',
+ brain_regions: ['FP'],
+ },
+ {
+ source: 'ENSG00000135046',
+ target: 'ENSG00000102265',
+ source_hgnc_symbol: 'ANXA1',
+ target_hgnc_symbol: 'TIMP1',
+ brain_regions: ['STG'],
+ },
+ {
+ source: 'ENSG00000135363',
+ target: 'ENSG00000111145',
+ source_hgnc_symbol: 'LMO2',
+ target_hgnc_symbol: 'ELK3',
+ brain_regions: ['DLPFC'],
+ },
+ {
+ source: 'ENSG00000135363',
+ target: 'ENSG00000131724',
+ source_hgnc_symbol: 'LMO2',
+ target_hgnc_symbol: 'IL13RA1',
+ brain_regions: ['FP'],
+ },
+ {
+ source: 'ENSG00000135363',
+ target: 'ENSG00000101160',
+ source_hgnc_symbol: 'LMO2',
+ target_hgnc_symbol: 'CTSZ',
+ brain_regions: ['PHG'],
+ },
+ {
+ source: 'ENSG00000137285',
+ target: 'ENSG00000087086',
+ source_hgnc_symbol: 'TUBB2B',
+ target_hgnc_symbol: 'FTL',
+ brain_regions: ['DLPFC'],
+ },
+ {
+ source: 'ENSG00000137285',
+ target: 'ENSG00000166340',
+ source_hgnc_symbol: 'TUBB2B',
+ target_hgnc_symbol: 'TPP1',
+ brain_regions: ['CBE'],
+ },
+ {
+ source: 'ENSG00000155366',
+ target: 'ENSG00000018408',
+ source_hgnc_symbol: 'RHOC',
+ target_hgnc_symbol: 'WWTR1',
+ brain_regions: ['FP'],
+ },
+ {
+ source: 'ENSG00000163191',
+ target: 'ENSG00000111321',
+ source_hgnc_symbol: 'S100A11',
+ target_hgnc_symbol: 'LTBR',
+ brain_regions: ['TCX'],
+ },
+ {
+ source: 'ENSG00000163191',
+ target: 'ENSG00000135046',
+ source_hgnc_symbol: 'S100A11',
+ target_hgnc_symbol: 'ANXA1',
+ brain_regions: ['CBE'],
+ },
+ {
+ source: 'ENSG00000166340',
+ target: 'ENSG00000087086',
+ source_hgnc_symbol: 'TPP1',
+ target_hgnc_symbol: 'FTL',
+ brain_regions: ['DLPFC'],
+ },
+ {
+ source: 'ENSG00000168309',
+ target: 'ENSG00000087086',
+ source_hgnc_symbol: 'FAM107A',
+ target_hgnc_symbol: 'FTL',
+ brain_regions: ['PHG'],
+ },
+ {
+ source: 'ENSG00000168899',
+ target: 'ENSG00000018408',
+ source_hgnc_symbol: 'VAMP5',
+ target_hgnc_symbol: 'WWTR1',
+ brain_regions: ['TCX'],
+ },
+ {
+ source: 'ENSG00000169504',
+ target: 'ENSG00000132561',
+ source_hgnc_symbol: 'CLIC4',
+ target_hgnc_symbol: 'MATN2',
+ brain_regions: ['DLPFC'],
+ },
+ {
+ source: 'ENSG00000169504',
+ target: 'ENSG00000102265',
+ source_hgnc_symbol: 'CLIC4',
+ target_hgnc_symbol: 'TIMP1',
+ brain_regions: ['DLPFC'],
+ },
+ {
+ source: 'ENSG00000169504',
+ target: 'ENSG00000117519',
+ source_hgnc_symbol: 'CLIC4',
+ target_hgnc_symbol: 'CNN3',
+ brain_regions: ['FP'],
+ },
+ {
+ source: 'ENSG00000170989',
+ target: 'ENSG00000113140',
+ source_hgnc_symbol: 'S1PR1',
+ target_hgnc_symbol: 'SPARC',
+ brain_regions: ['CBE'],
+ },
+ {
+ source: 'ENSG00000170989',
+ target: 'ENSG00000137285',
+ source_hgnc_symbol: 'S1PR1',
+ target_hgnc_symbol: 'TUBB2B',
+ brain_regions: ['CBE'],
+ },
+ {
+ source: 'ENSG00000170989',
+ target: 'ENSG00000136754',
+ source_hgnc_symbol: 'S1PR1',
+ target_hgnc_symbol: 'ABI1',
+ brain_regions: ['CBE'],
+ },
+ {
+ source: 'ENSG00000170989',
+ target: 'ENSG00000166340',
+ source_hgnc_symbol: 'S1PR1',
+ target_hgnc_symbol: 'TPP1',
+ brain_regions: ['CBE'],
+ },
+ {
+ source: 'ENSG00000172164',
+ target: 'ENSG00000119408',
+ source_hgnc_symbol: 'SNTB1',
+ target_hgnc_symbol: 'NEK6',
+ brain_regions: ['CBE'],
+ },
+ {
+ source: 'ENSG00000174021',
+ target: 'ENSG00000155366',
+ source_hgnc_symbol: 'GNG5',
+ target_hgnc_symbol: 'RHOC',
+ brain_regions: ['CBE', 'DLPFC', 'FP', 'IFG', 'PHG'],
+ },
+ {
+ source: 'ENSG00000174021',
+ target: 'ENSG00000111348',
+ source_hgnc_symbol: 'GNG5',
+ target_hgnc_symbol: 'ARHGDIB',
+ brain_regions: ['FP'],
+ },
+ {
+ source: 'ENSG00000174021',
+ target: 'ENSG00000168899',
+ source_hgnc_symbol: 'GNG5',
+ target_hgnc_symbol: 'VAMP5',
+ brain_regions: ['PHG'],
+ },
+ {
+ source: 'ENSG00000174021',
+ target: 'ENSG00000135363',
+ source_hgnc_symbol: 'GNG5',
+ target_hgnc_symbol: 'LMO2',
+ brain_regions: ['IFG'],
+ },
+ {
+ source: 'ENSG00000177119',
+ target: 'ENSG00000111145',
+ source_hgnc_symbol: 'ANO6',
+ target_hgnc_symbol: 'ELK3',
+ brain_regions: ['IFG'],
+ },
+ {
+ source: 'ENSG00000174021',
+ target: 'ENSG00000147065',
+ source_hgnc_symbol: 'GNG5',
+ target_hgnc_symbol: 'MSN',
+ brain_regions: ['CBE', 'FP'],
+ },
+ {
+ source: 'ENSG00000018408',
+ target: 'ENSG00000134531',
+ source_hgnc_symbol: 'WWTR1',
+ target_hgnc_symbol: 'EMP1',
+ brain_regions: ['DLPFC', 'FP'],
+ },
+ {
+ source: 'ENSG00000111321',
+ target: 'ENSG00000141510',
+ source_hgnc_symbol: 'LTBR',
+ target_hgnc_symbol: 'TP53',
+ brain_regions: ['DLPFC', 'FP'],
+ },
+ {
+ source: 'ENSG00000117226',
+ target: 'ENSG00000135046',
+ source_hgnc_symbol: 'GBP3',
+ target_hgnc_symbol: 'ANXA1',
+ brain_regions: ['IFG', 'PHG'],
+ },
+ {
+ source: 'ENSG00000135046',
+ target: 'ENSG00000134531',
+ source_hgnc_symbol: 'ANXA1',
+ target_hgnc_symbol: 'EMP1',
+ brain_regions: ['FP', 'TCX'],
+ },
+ {
+ source: 'ENSG00000155366',
+ target: 'ENSG00000137285',
+ source_hgnc_symbol: 'RHOC',
+ target_hgnc_symbol: 'TUBB2B',
+ brain_regions: ['PHG', 'TCX'],
+ },
+ {
+ source: 'ENSG00000155366',
+ target: 'ENSG00000177119',
+ source_hgnc_symbol: 'RHOC',
+ target_hgnc_symbol: 'ANO6',
+ brain_regions: ['FP', 'STG'],
+ },
+ {
+ source: 'ENSG00000163191',
+ target: 'ENSG00000102265',
+ source_hgnc_symbol: 'S100A11',
+ target_hgnc_symbol: 'TIMP1',
+ brain_regions: ['CBE', 'DLPFC'],
+ },
+ {
+ source: 'ENSG00000168899',
+ target: 'ENSG00000087086',
+ source_hgnc_symbol: 'VAMP5',
+ target_hgnc_symbol: 'FTL',
+ brain_regions: ['CBE', 'DLPFC'],
+ },
+ {
+ source: 'ENSG00000169504',
+ target: 'ENSG00000177119',
+ source_hgnc_symbol: 'CLIC4',
+ target_hgnc_symbol: 'ANO6',
+ brain_regions: ['DLPFC', 'FP'],
+ },
+ {
+ source: 'ENSG00000135046',
+ target: 'ENSG00000147065',
+ source_hgnc_symbol: 'ANXA1',
+ target_hgnc_symbol: 'MSN',
+ brain_regions: ['CBE', 'DLPFC', 'TCX'],
+ },
+ {
+ source: 'ENSG00000134871',
+ target: 'ENSG00000102265',
+ source_hgnc_symbol: 'COL4A2',
+ target_hgnc_symbol: 'TIMP1',
+ brain_regions: ['DLPFC', 'IFG', 'TCX'],
+ },
+ {
+ source: 'ENSG00000134871',
+ target: 'ENSG00000196924',
+ source_hgnc_symbol: 'COL4A2',
+ target_hgnc_symbol: 'FLNA',
+ brain_regions: ['FP', 'IFG', 'PHG'],
+ },
+ {
+ source: 'ENSG00000141510',
+ target: 'ENSG00000168610',
+ source_hgnc_symbol: 'TP53',
+ target_hgnc_symbol: 'STAT3',
+ brain_regions: ['FP', 'PHG', 'TCX'],
+ },
+ {
+ source: 'ENSG00000155366',
+ target: 'ENSG00000168899',
+ source_hgnc_symbol: 'RHOC',
+ target_hgnc_symbol: 'VAMP5',
+ brain_regions: ['CBE', 'DLPFC', 'TCX'],
+ },
+ {
+ source: 'ENSG00000170989',
+ target: 'ENSG00000120278',
+ source_hgnc_symbol: 'S1PR1',
+ target_hgnc_symbol: 'PLEKHG1',
+ brain_regions: ['DLPFC', 'IFG', 'TCX'],
+ },
+ {
+ source: 'ENSG00000134531',
+ target: 'ENSG00000147065',
+ source_hgnc_symbol: 'EMP1',
+ target_hgnc_symbol: 'MSN',
+ brain_regions: ['FP', 'PHG', 'STG', 'TCX'],
+ },
+ {
+ source: 'ENSG00000111348',
+ target: 'ENSG00000101160',
+ source_hgnc_symbol: 'ARHGDIB',
+ target_hgnc_symbol: 'CTSZ',
+ brain_regions: ['DLPFC', 'IFG', 'PHG', 'TCX'],
+ },
+ {
+ source: 'ENSG00000117519',
+ target: 'ENSG00000137285',
+ source_hgnc_symbol: 'CNN3',
+ target_hgnc_symbol: 'TUBB2B',
+ brain_regions: ['DLPFC', 'FP', 'IFG', 'PHG', 'STG'],
+ },
+ {
+ source: 'ENSG00000117519',
+ target: 'ENSG00000119408',
+ source_hgnc_symbol: 'CNN3',
+ target_hgnc_symbol: 'NEK6',
+ brain_regions: ['CBE', 'DLPFC', 'FP', 'PHG', 'TCX'],
+ },
+ {
+ source: 'ENSG00000111348',
+ target: 'ENSG00000163191',
+ source_hgnc_symbol: 'ARHGDIB',
+ target_hgnc_symbol: 'S100A11',
+ brain_regions: ['CBE', 'DLPFC', 'FP', 'IFG', 'PHG', 'STG', 'TCX'],
+ },
+ ],
+ min: 0,
+ max: 7,
+ },
+ bio_domains: {
+ ensembl_gene_id: "ENSG00000147065",
+ gene_biodomains: [
+ {
+ biodomain: "Structural Stabilization",
+ go_terms: [
+ "cytoskeleton",
+ "focal adhesion",
+ "cytoskeleton organization",
+ "adherens junction",
+ "structural constituent of cytoskeleton",
+ "cell adhesion molecule binding"
+ ],
+ n_biodomain_terms: 466,
+ n_gene_biodomain_terms: 6,
+ pct_linking_terms: 40
+ },
+ {
+ biodomain: "Immune Response",
+ go_terms: [
+ "leukocyte migration",
+ "T cell proliferation",
+ "immunological synapse formation",
+ "T cell migration",
+ "leukocyte cell-cell adhesion"
+ ],
+ n_biodomain_terms: 852,
+ n_gene_biodomain_terms: 5,
+ pct_linking_terms: 33.33
+ },
+ {
+ biodomain: "Lipid Metabolism",
+ go_terms: [
+ "basolateral plasma membrane",
+ "cellular response to testosterone stimulus"
+ ],
+ n_biodomain_terms: 827,
+ n_gene_biodomain_terms: 2,
+ pct_linking_terms: 13.33
+ },
+ {
+ biodomain: "Synapse",
+ go_terms: [
+ "signaling receptor binding"
+ ],
+ n_biodomain_terms: 891,
+ n_gene_biodomain_terms: 1,
+ pct_linking_terms: 6.67
+ },
+ {
+ biodomain: "Vasculature",
+ go_terms: [
+ "blood microparticle"
+ ],
+ n_biodomain_terms: 315,
+ n_gene_biodomain_terms: 1,
+ pct_linking_terms: 6.67
+ },
+ ]
+ },
+ is_adi: false,
+ is_tep: true,
+ resource_url: 'https://adknowledgeportal.synapse.org/Explore/Target%20Enabling%20Resources?QueryWrapper0=%7B%22sql%22%3A%22select%20*%20from%20syn26146692%20WHERE%20%60isPublic%60%20%3D%20true%22%2C%22limit%22%3A25%2C%22offset%22%3A0%2C%22selectedFacets%22%3A%5B%7B%22concreteType%22%3A%22org.sagebionetworks.repo.model.table.FacetColumnValuesRequest%22%2C%22columnName%22%3A%22target%22%2C%22facetValues%22%3A%5B%22MSN%22%5D%7D%5D%7D',
+ ensembl_info: [
+ ]
+}
+
export const geneMock1: Gene = {
_id: '628ea1be0e8d04279fdbaa26',
ensembl_gene_id: 'ENSG00000147065',
@@ -2934,7 +3935,14 @@ export const geneMock1: Gene = {
},
is_adi: false,
is_tep: true,
- resource_url: 'https://adknowledgeportal.synapse.org/Explore/Target%20Enabling%20Resources?QueryWrapper0=%7B%22sql%22%3A%22select%20*%20from%20syn26146692%20WHERE%20%60isPublic%60%20%3D%20true%22%2C%22limit%22%3A25%2C%22offset%22%3A0%2C%22selectedFacets%22%3A%5B%7B%22concreteType%22%3A%22org.sagebionetworks.repo.model.table.FacetColumnValuesRequest%22%2C%22columnName%22%3A%22target%22%2C%22facetValues%22%3A%5B%22MSN%22%5D%7D%5D%7D'
+ resource_url: 'https://adknowledgeportal.synapse.org/Explore/Target%20Enabling%20Resources?QueryWrapper0=%7B%22sql%22%3A%22select%20*%20from%20syn26146692%20WHERE%20%60isPublic%60%20%3D%20true%22%2C%22limit%22%3A25%2C%22offset%22%3A0%2C%22selectedFacets%22%3A%5B%7B%22concreteType%22%3A%22org.sagebionetworks.repo.model.table.FacetColumnValuesRequest%22%2C%22columnName%22%3A%22target%22%2C%22facetValues%22%3A%5B%22MSN%22%5D%7D%5D%7D',
+ ensembl_info: [
+ {
+ ensembl_release: 84,
+ ensembl_possible_replacements: ['ENSG00000283172'],
+ ensembl_permalink: 'https://may2015.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000264794'
+ }
+ ]
};
export const geneMock2: Gene = {
@@ -3121,7 +4129,14 @@ export const geneMock2: Gene = {
total_nominations: 3,
is_adi: false,
is_tep: true,
- resource_url: 'https://adknowledgeportal.synapse.org/Explore/Target%20Enabling%20Resources?QueryWrapper0=%7B%22sql%22%3A%22select%20*%20from%20syn26146692%20WHERE%20%60isPublic%60%20%3D%20true%22%2C%22limit%22%3A25%2C%22offset%22%3A0%2C%22selectedFacets%22%3A%5B%7B%22concreteType%22%3A%22org.sagebionetworks.repo.model.table.FacetColumnValuesRequest%22%2C%22columnName%22%3A%22target%22%2C%22facetValues%22%3A%5B%22PLEC%22%5D%7D%5D%7D'
+ resource_url: 'https://adknowledgeportal.synapse.org/Explore/Target%20Enabling%20Resources?QueryWrapper0=%7B%22sql%22%3A%22select%20*%20from%20syn26146692%20WHERE%20%60isPublic%60%20%3D%20true%22%2C%22limit%22%3A25%2C%22offset%22%3A0%2C%22selectedFacets%22%3A%5B%7B%22concreteType%22%3A%22org.sagebionetworks.repo.model.table.FacetColumnValuesRequest%22%2C%22columnName%22%3A%22target%22%2C%22facetValues%22%3A%5B%22PLEC%22%5D%7D%5D%7D',
+ ensembl_info: [
+ {
+ ensembl_release: 84,
+ ensembl_possible_replacements: ['ENSG00000283172, ENSG00000283172'],
+ ensembl_permalink: 'https://may2015.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000264794'
+ }
+ ]
};
export const geneMock3: Gene = {
@@ -3243,7 +4258,14 @@ export const geneMock3: Gene = {
total_nominations: null,
is_adi: false,
is_tep: true,
- resource_url: null
+ resource_url: null,
+ ensembl_info: [
+ {
+ ensembl_release: 84,
+ ensembl_possible_replacements: ['ENSG00000283172, ENSG00000283172'],
+ ensembl_permalink: 'https://may2015.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000264794'
+ }
+ ]
};
export const gctGeneMock1: GCTGene = {
@@ -3421,7 +4443,14 @@ export const nominatedGeneMock1: Gene = {
total_nominations: 4,
is_adi: false,
is_tep: false,
- resource_url: null
+ resource_url: null,
+ ensembl_info: [
+ {
+ ensembl_release: 84,
+ ensembl_possible_replacements: ['ENSG00000283172, ENSG00000283172'],
+ ensembl_permalink: 'https://may2015.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000264794'
+ }
+ ]
} as Gene;
export const noHGNCgeneMock: Gene = {
@@ -3518,5 +4547,12 @@ export const noHGNCgeneMock: Gene = {
total_nominations: 4,
is_adi: false,
is_tep: false,
- resource_url: null
+ resource_url: null,
+ ensembl_info: [
+ {
+ ensembl_release: 84,
+ ensembl_possible_replacements: ['ENSG00000283172, ENSG00000283172'],
+ ensembl_permalink: 'https://may2015.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000264794'
+ }
+ ]
} as Gene;
diff --git a/src/server/api.ts b/src/server/api.ts
index d7ee9643..468f58f7 100644
--- a/src/server/api.ts
+++ b/src/server/api.ts
@@ -69,7 +69,7 @@ if (
],
{ region: 'us-east-1' }
);
-
+
if (results && results.Parameters) {
database.url =
'mongodb://' +
diff --git a/src/server/models/genes.ts b/src/server/models/genes.ts
index 94465fca..ac077977 100644
--- a/src/server/models/genes.ts
+++ b/src/server/models/genes.ts
@@ -12,6 +12,7 @@ import {
TargetNomination,
Druggability,
} from '../../app/models';
+import { EnsemblInfo } from '../../app/models/EnsemblInfo';
export { Gene } from '../../app/models';
// -------------------------------------------------------------------------- //
@@ -42,6 +43,12 @@ const MedianExpressionSchema = new Schema
({
tissue: { type: String, required: true },
});
+const EnsemblInfoSchema = new Schema({
+ ensembl_release: { type: Number, required: true },
+ ensembl_possible_replacements: { type: [String], required: true },
+ ensembl_permalink: { type: String, required: true }
+});
+
const DruggabilitySchema = new Schema({
sm_druggability_bucket: { type: Number, required: true },
safety_bucket: { type: Number, required: true },
@@ -70,6 +77,7 @@ const GeneSchema = new Schema(
median_expression: { type: [MedianExpressionSchema], required: true },
druggability: { type: [DruggabilitySchema], required: true },
total_nominations: { type: Number, required: true },
+ ensembl_info: { type: [EnsemblInfoSchema], required: true }
},
{ collection: 'geneinfo' }
);
diff --git a/tests/nominated-targets.spec.ts.disabled b/tests/nominated-targets.spec.ts
similarity index 100%
rename from tests/nominated-targets.spec.ts.disabled
rename to tests/nominated-targets.spec.ts
diff --git a/tests/similar-genes.spec.ts.disabled b/tests/similar-genes.spec.ts
similarity index 100%
rename from tests/similar-genes.spec.ts.disabled
rename to tests/similar-genes.spec.ts