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eQTL

The eQTL folder has the code for generating enhancer-gene links from eQTL data taken from the source - https://storage.googleapis.com/gtex_analysis_v7/single_tissue_eqtl_data/GTEx_Analysis_v7_eQTL.tar.gz.

python eqtl.py

Running the above command generates linksDBeqtl and linksDBnumeqtl files that are the concatention of all the files of respective nature generated from different tissue variant gene pair files.

linksDBeqtl

$ head linksDBeqtl 
7	HUMAN|HGNC=23517|UniProtKB=Q8N2H3	10_100169983_A_G_b37	4.57077e-11	23	2
7	HUMAN|HGNC=23517|UniProtKB=Q8N2H3	10_100170037_A_G_b37	7.59471e-11	23	2
7	HUMAN|HGNC=23517|UniProtKB=Q8N2H3	10_100170209_T_C_b37	4.57077e-11	23	2
12	HUMAN|HGNC=28228|UniProtKB=Q96DD0	1_100502868_T_TATAC_b37	4.09143e-08	23	2
16	HUMAN|HGNC=28228|UniProtKB=Q96DD0	1_100555192_A_G_b37	1.5892e-07	23	2
62	HUMAN|HGNC=25613|UniProtKB=Q69YN2	10_101854930_CA_C_b37	5.74856e-06	23	2
63	HUMAN|HGNC=25613|UniProtKB=Q69YN2	10_101863410_C_A_b37	3.37568e-06	23	2
88	HUMAN|HGNC=17452|UniProtKB=Q9HBK9	10_104585405_A_T_b37	2.15079e-08	23	2
92	HUMAN|HGNC=7642|UniProtKB=Q99747	18_10497034_G_A_b37	2.43176e-06	23	2
317	HUMAN|HGNC=28769|UniProtKB=Q6UX65	1_111733724_G_C_b37	1.98817e-07	23	2

linksDBnumeqtl

$ head linksDBnumeqtl 
enhancer	gene	tissue	number_of_eQTL	assay
1026	HUMAN|HGNC=378|UniProtKB=O43823	23	1	2
12	HUMAN|HGNC=28228|UniProtKB=Q96DD0	23	1	2
1212	HUMAN|HGNC=264|UniProtKB=P29275	23	1	2
1213	HUMAN|HGNC=264|UniProtKB=P29275	23	1	2
1295	HUMAN|HGNC=19359|UniProtKB=Q5VWW1	23	1	2
1410	HUMAN|HGNC=28793|UniProtKB=O95568	23	1	2
1411	HUMAN|HGNC=28793|UniProtKB=O95568	23	1	2
16	HUMAN|HGNC=28228|UniProtKB=Q96DD0	23	1	2
1630	HUMAN|HGNC=11984|UniProtKB=Q6ZVM7	23	1	2