diff --git a/filters.py b/filters.py
index aeef5d6..aa6f76b 100644
--- a/filters.py
+++ b/filters.py
@@ -42,10 +42,25 @@ def geometry(self) -> QgsGeometry:
         return QgsGeometry.fromWkt(self.wkt)
 
     def filterString(self, layer: QgsVectorLayer) -> str:
-        template = "ST_{predicate}({geom_name}, ST_TRANSFORM(ST_GeomFromText('{wkt}', {srid}), {layer_srid}))"
+        """Returns a layer filter string corresponding to the filter definition.
+
+        Args:
+            layer (QgsVectorLayer): The layer for which the filter should be applied
+
+        Returns:
+            str: A layer filter string
+        """
+
+        # ST_DISJOINT does not use spatial indexes, but we can use its opposite "NOT ST_INTERSECTS" which does
+        if self.predicate == Predicate.DISJOINT:
+            spatial_predicate = "NOT ST_INTERSECTS"
+        else:
+            spatial_predicate = f"ST_{Predicate(self.predicate).name}"
+
+        template = "{spatial_predicate}({geom_name}, ST_TRANSFORM(ST_GeomFromText('{wkt}', {srid}), {layer_srid}))"
         geom_name = getLayerGeomName(layer)
         return template.format(
-            predicate=Predicate(self.predicate).name,
+            spatial_predicate=spatial_predicate,
             geom_name=geom_name,
             wkt=self.wkt,
             srid=self.crs.postgisSrid(),
@@ -112,4 +127,4 @@ def askOverwrite(self, name: str) -> bool:
     def askDelete(self, name: str) -> bool:
         txt = self.tr('Delete filter')
         return QMessageBox.question(iface.mainWindow(), self.tr('Delete?'), f'{txt} <i>{name}</i>?',
-                                    QMessageBox.Yes, QMessageBox.No) == QMessageBox.Yes
\ No newline at end of file
+                                    QMessageBox.Yes, QMessageBox.No) == QMessageBox.Yes