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Question on how to interpret the "Distance" column in search_space.tsv #537

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zhli12 opened this issue Jan 25, 2025 · 0 comments
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@zhli12
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zhli12 commented Jan 25, 2025

When I examined the outputs of SCENICplus tutorial, I found that for some genes, there are tens or even a hundred regions with a distance of 0 that do not overlap with each other.
I read in a pull request (#46) that "the distance from regions to genes by taking the minimum between a. the distance from the region to the start of the gene (the TSS) and b. the distance from the region to the end of the gene. This distance is reported for informational purposes only, but is not used internally." Given that the consensus peaks are non-overlapping, does this mean that for any gene there can be at most 2 regions with Distance being 0? The number of regions I got with Distance =0 for a single gene seem a bit weird to me. Does anyone know whether this is normal or how I should interpret it?

Thanks!

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