diff --git a/packages/cli/package.json b/packages/cli/package.json
index f5f7dea8..f29074a7 100644
--- a/packages/cli/package.json
+++ b/packages/cli/package.json
@@ -41,7 +41,9 @@
     "postcss-nested": "^5.0.6",
     "postcss-preset-env": "^7.0.2",
     "postcss-reporter": "^7.0.4",
+    "postcss-value-parser": "^4.2.0",
     "resolve": "^1.19.0",
+    "stylis": "^3.5.4",
     "terser-webpack-plugin": "^5.3.0",
     "thread-loader": "^3.0.4",
     "tslib": "^2.3.0",
diff --git a/packages/cli/src/config/__tests__/__snapshots__/postcssLinariaPreprocessor.test.ts.snap b/packages/cli/src/config/__tests__/__snapshots__/postcssLinariaPreprocessor.test.ts.snap
new file mode 100644
index 00000000..cddeba3e
--- /dev/null
+++ b/packages/cli/src/config/__tests__/__snapshots__/postcssLinariaPreprocessor.test.ts.snap
@@ -0,0 +1,42 @@
+// Jest Snapshot v1, https://goo.gl/fbAQLP
+
+exports[`postcss-linaria-preprocessor :global() selector 1`] = `
+"
+      .a {
+        color: red
+      }
+          page {
+            width: 50vw;
+          }
+    "
+`;
+
+exports[`postcss-linaria-preprocessor escape breaking control characters 1`] = `
+"
+      .a {
+        content: '\\\\feff';
+      }
+    "
+`;
+
+exports[`postcss-linaria-preprocessor keyframes rename 1`] = `
+"
+      .a {
+        animation: 1s ease 1 backwards normal zoomIn-a;
+        @keyframes zoomIn-a {
+          from {
+            opacity: 0;
+            transform: scale(0.94);
+          }
+
+          50% {
+            opacity: var(--opacity);
+          }
+
+          to {
+            transform: scale(var(--scale));
+          }
+        }
+      }
+    "
+`;
diff --git a/packages/cli/src/config/__tests__/__snapshots__/postcssTransformUnit.test.ts.snap b/packages/cli/src/config/__tests__/__snapshots__/postcssTransformUnit.test.ts.snap
new file mode 100644
index 00000000..e6fb0479
--- /dev/null
+++ b/packages/cli/src/config/__tests__/__snapshots__/postcssTransformUnit.test.ts.snap
@@ -0,0 +1,21 @@
+// Jest Snapshot v1, https://goo.gl/fbAQLP
+
+exports[`postcss-transform-unit px to rpx 1`] = `
+"
+      .a {
+        width: 20rpx;
+        height: 20rpx;
+        font-size: 30px;
+      }
+    "
+`;
+
+exports[`postcss-transform-unit rpx to px 1`] = `
+"
+      .a {
+        width: 10px;
+        height: 10px;
+        font-size: 30rpx;
+      }
+    "
+`;
diff --git a/packages/cli/src/config/__tests__/postcssLinariaPreprocessor.test.ts b/packages/cli/src/config/__tests__/postcssLinariaPreprocessor.test.ts
new file mode 100644
index 00000000..9a8f6946
--- /dev/null
+++ b/packages/cli/src/config/__tests__/postcssLinariaPreprocessor.test.ts
@@ -0,0 +1,57 @@
+import postcss from 'postcss';
+
+const transform = async (css: string) => {
+  // eslint-disable-next-line global-require
+  const result = await postcss([require('../postcssLinariaPreprocessor')()]).process(css, {
+    from: '/path/to/file.css',
+  });
+  return result.css;
+};
+
+describe('postcss-linaria-preprocessor', () => {
+  test(':global() selector', () => {
+    const css = `
+      .a {
+        color: red;
+        :global() {
+          page {
+            width: 50vw;
+          }
+        }
+      }
+    `;
+    expect(transform(css)).resolves.toMatchSnapshot();
+  });
+
+  test('keyframes rename', () => {
+    const css = `
+      .a {
+        animation: 1s ease 1 backwards normal zoomIn;
+        @keyframes zoomIn {
+          from {
+            opacity: 0;
+            transform: scale(0.94);
+          }
+
+          50% {
+            opacity: var(--opacity);
+          }
+
+          to {
+            transform: scale(var(--scale));
+          }
+        }
+      }
+    `;
+    expect(transform(css)).resolves.toMatchSnapshot();
+  });
+
+  test('escape breaking control characters', () => {
+    const css = `
+      .a {
+        content: '\feff';
+      }
+    `;
+    expect(transform(css)).resolves.toMatchSnapshot();
+  });
+});
diff --git a/packages/cli/src/config/__tests__/postcssTransformUnit.test.ts b/packages/cli/src/config/__tests__/postcssTransformUnit.test.ts
new file mode 100644
index 00000000..e47b35a9
--- /dev/null
+++ b/packages/cli/src/config/__tests__/postcssTransformUnit.test.ts
@@ -0,0 +1,49 @@
+import postcss from 'postcss';
+
+describe('postcss-transform-unit', () => {
+  test('px to rpx', async () => {
+    const css = `
+      .a {
+        width: 10px;
+        height: 20rpx;
+        font-size: 30px; /* no */
+      }
+    `;
+
+    const result = await postcss([
+      // eslint-disable-next-line global-require
+      require('../postcssTransformUnit')({
+        divisor: 1,
+        multiple: 2,
+        sourceUnit: 'px',
+        targetUnit: 'rpx',
+      }),
+    ]).process(css, {
+      from: '/path/to/file.css',
+    });
+    expect(result.css).toMatchSnapshot();
+  });
+
+  test('rpx to px', async () => {
+    const css = `
+      .a {
+        width: 10px;
+        height: 20rpx;
+        font-size: 30rpx; /* no */
+      }
+    `;
+
+    const result = await postcss([
+      // eslint-disable-next-line global-require
+      require('../postcssTransformUnit')({
+        divisor: 2,
+        multiple: 1,
+        sourceUnit: 'rpx',
+        targetUnit: 'px',
+      }),
+    ]).process(css, {
+      from: '/path/to/file.css',
+    });
+    expect(result.css).toMatchSnapshot();
+  });
+});
diff --git a/packages/cli/src/config/postcssConfig.ts b/packages/cli/src/config/postcssConfig.ts
index bc7070fa..cfe07b60 100644
--- a/packages/cli/src/config/postcssConfig.ts
+++ b/packages/cli/src/config/postcssConfig.ts
@@ -33,12 +33,13 @@ const getTransformUnitsPlugin = (unit: TransformUnit) => {
 // to improve PostCSS performance, we should always use `require(name)(options)` rather than `[name, options]`
 // also we should set `postcssOptions.config` to `false` to avoid loading any `postcss.config.js`
 // TODO: hope PostCSS could fix this issue https://github.com/csstools/postcss-preset-env/issues/232#issuecomment-992263741
-export default ({ unit }: { unit: TransformUnit }) => {
+export default ({ unit, linaria }: { unit: TransformUnit; linaria: boolean }) => {
   const transformUnitPlugin = getTransformUnitsPlugin(unit);
 
   return {
     plugins: [
       require('postcss-each')(),
+      ...(linaria ? [require('./postcssLinariaPreprocessor')()] : []),
       // TODO: `postcss-nesting` from `postcss-preset-env` output `:is` pseudo-class that Mini Programs don't support.
       // We have to use `postcss-nested` manually before them to prevent `:is` being created.
       require('postcss-nested')(),
diff --git a/packages/cli/src/config/postcssLinariaPreprocessor.ts b/packages/cli/src/config/postcssLinariaPreprocessor.ts
new file mode 100644
index 00000000..16df9480
--- /dev/null
+++ b/packages/cli/src/config/postcssLinariaPreprocessor.ts
@@ -0,0 +1,91 @@
+/* eslint-disable import/no-import-module-exports */
+import type { PluginCreator } from 'postcss';
+import valueParser from 'postcss-value-parser';
+
+const reserved = [
+  'none',
+  'inherited',
+  'initial',
+  'unset',
+  /* single-timing-function */
+  'linear',
+  'ease',
+  'ease-in',
+  'ease-in-out',
+  'ease-out',
+  'step-start',
+  'step-end',
+  'start',
+  'end',
+  /* single-animation-iteration-count */
+  'infinite',
+  /* single-animation-direction */
+  'normal',
+  'reverse',
+  'alternate',
+  'alternate-reverse',
+  /* single-animation-fill-mode */
+  'forwards',
+  'backwards',
+  'both',
+  /* single-animation-play-state */
+  'running',
+  'paused',
+];
+
+interface Options {}
+
+const postcssLinariaPreprocessor: PluginCreator<Options> = () => ({
+  postcssPlugin: 'postcss-linaria-preprocessor',
+  Once(root, postcss) {
+    const nodes = [...root.nodes];
+    for (const node of nodes) {
+      if (node.type === 'rule' && node.selector.startsWith('.')) {
+        // use unique keyframe name to avoid conflict
+        // inspired from https://github.com/css-modules/postcss-icss-keyframes/blob/5f890e4068820daa80025d88a4f750a3a085dcc8/src/index.js
+        const keyframeNameMapping = new Map<string, string>();
+        node.walkAtRules(/keyframes$/, atRule => {
+          const name = atRule.params;
+          if (reserved.includes(name)) {
+            postcss.result.warn(`Unable to use reserve '${name}' animation name`, {
+              node: atRule,
+            });
+
+            return;
+          }
+          const newName = `${name}-${node.selector.replace(/^\./, '')}`;
+          keyframeNameMapping.set(name, newName);
+          atRule.params = newName;
+        });
+        node.walkDecls(/animation$|animation-name$/, decl => {
+          const parsed = valueParser(decl.value);
+          for (const item of parsed.nodes) {
+            if (item.type === 'word' && keyframeNameMapping.has(item.value)) {
+              item.value = keyframeNameMapping.get(item.value)!;
+            }
+          }
+          decl.value = parsed.toString();
+        });
+
+        // extract the global rule to the top of the root
+        node.walkRules(/^:global\(\)$/, globalRule => {
+          globalRule.remove();
+          for (const globalNode of globalRule.nodes) {
+            root.insertAfter(node, globalNode);
+          }
+        });
+      }
+    }
+  },
+  Declaration(decl) {
+    // escape breaking control characters
+    // from: https://github.com/thysultan/stylis/blob/v3.5.4/tests/spec.js#L113C3-L116
+    if (decl.value.match(/[\0\r\f]/)) {
+      decl.value = decl.value.replace(/\0/g, '\\0').replace(/\r/g, '\\r').replace(/\f/g, '\\f');
+    }
+  },
+});
+
+postcssLinariaPreprocessor.postcss = true;
+
+module.exports = postcssLinariaPreprocessor;
diff --git a/packages/cli/src/config/webpack.config.ts b/packages/cli/src/config/webpack.config.ts
index b980abc0..3cd20ea7 100644
--- a/packages/cli/src/config/webpack.config.ts
+++ b/packages/cli/src/config/webpack.config.ts
@@ -193,6 +193,7 @@ export const getWebpackConfig = ({
                 configFile: require.resolve('./linaria.config'),
                 sourceMap: true,
                 cacheProvider: require.resolve('./linariaFileCache'),
+                preprocessor: 'none',
                 babelOptions: {
                   // always use internal babel.config.js file
                   configFile: require.resolve('./babel.config'),
@@ -232,7 +233,7 @@ export const getWebpackConfig = ({
                 implementation: require.resolve('postcss'),
                 postcssOptions: {
                   config: false,
-                  ...postcssConfig({ unit: cssUnit }),
+                  ...postcssConfig({ unit: cssUnit, linaria: false }),
                 },
               },
             },
@@ -269,7 +270,7 @@ export const getWebpackConfig = ({
                 implementation: require.resolve('postcss'),
                 postcssOptions: {
                   config: false,
-                  ...postcssConfig({ unit: cssUnit }),
+                  ...postcssConfig({ unit: cssUnit, linaria: true }),
                 },
               },
             },
diff --git a/packages/demo-todomvc-linaria/src/components/MainSection.tsx b/packages/demo-todomvc-linaria/src/components/MainSection.tsx
index 17b299b6..eccde02c 100644
--- a/packages/demo-todomvc-linaria/src/components/MainSection.tsx
+++ b/packages/demo-todomvc-linaria/src/components/MainSection.tsx
@@ -16,7 +16,7 @@ const main = css`
 const todosHeader = css`
   padding: 10px 0;
   width: 100%;
-  font-size: 100px;
+  font-size: 203rpx;
   font-weight: 100;
   text-align: center;
   color: rgba(175, 47, 47, 0.15);
diff --git a/yarn.lock b/yarn.lock
index e9638da4..7f9dc65f 100644
--- a/yarn.lock
+++ b/yarn.lock
@@ -2857,7 +2857,7 @@
     "@docusaurus/theme-search-algolia" "2.4.3"
     "@docusaurus/types" "2.4.3"
 
-"@docusaurus/react-loadable@5.5.2":
+"@docusaurus/react-loadable@5.5.2", "react-loadable@npm:@docusaurus/react-loadable@5.5.2":
   version "5.5.2"
   resolved "https://registry.yarnpkg.com/@docusaurus/react-loadable/-/react-loadable-5.5.2.tgz#81aae0db81ecafbdaee3651f12804580868fa6ce"
   integrity sha512-A3dYjdBGuy0IGT+wyLIGIKLRE+sAk1iNk0f1HjNDysO7u8lhL4N3VEm+FAubmJbAztn94F7MxBTPmnixbiyFdQ==
@@ -14224,14 +14224,6 @@ react-loadable-ssr-addon-v5-slorber@^1.0.1:
   dependencies:
     "@babel/runtime" "^7.10.3"
 
-"react-loadable@npm:@docusaurus/react-loadable@5.5.2":
-  version "5.5.2"
-  resolved "https://registry.yarnpkg.com/@docusaurus/react-loadable/-/react-loadable-5.5.2.tgz#81aae0db81ecafbdaee3651f12804580868fa6ce"
-  integrity sha512-A3dYjdBGuy0IGT+wyLIGIKLRE+sAk1iNk0f1HjNDysO7u8lhL4N3VEm+FAubmJbAztn94F7MxBTPmnixbiyFdQ==
-  dependencies:
-    "@types/react" "*"
-    prop-types "^15.6.2"
-
 react-reconciler@^0.26.2:
   version "0.26.2"
   resolved "https://registry.yarnpkg.com/react-reconciler/-/react-reconciler-0.26.2.tgz#bbad0e2d1309423f76cf3c3309ac6c96e05e9d91"