-
Notifications
You must be signed in to change notification settings - Fork 5
/
README.html
119 lines (111 loc) · 25.5 KB
/
README.html
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
<!DOCTYPE html>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<meta charset="utf-8">
<meta http-equiv="Content-Type" content="text/html; charset=utf-8" />
<meta name="generator" content="pandoc" />
<meta name="viewport" content="width=device-width, initial-scale=1">
<link href="data:text/css;charset=utf-8,%0A%40font%2Dface%20%7B%0Afont%2Dfamily%3A%20octicons%2Dlink%3B%0Asrc%3A%20url%28data%3Afont%2Fwoff%3Bcharset%3Dutf%2D8%3Bbase64%2Cd09GRgABAAAAAAZwABAAAAAACFQAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAABEU0lHAAAGaAAAAAgAAAAIAAAAAUdTVUIAAAZcAAAACgAAAAoAAQAAT1MvMgAAAyQAAABJAAAAYFYEU3RjbWFwAAADcAAAAEUAAACAAJThvmN2dCAAAATkAAAABAAAAAQAAAAAZnBnbQAAA7gAAACyAAABCUM%2B8IhnYXNwAAAGTAAAABAAAAAQABoAI2dseWYAAAFsAAABPAAAAZwcEq9taGVhZAAAAsgAAAA0AAAANgh4a91oaGVhAAADCAAAABoAAAAkCA8DRGhtdHgAAAL8AAAADAAAAAwGAACfbG9jYQAAAsAAAAAIAAAACABiATBtYXhwAAACqAAAABgAAAAgAA8ASm5hbWUAAAToAAABQgAAAlXu73sOcG9zdAAABiwAAAAeAAAAME3QpOBwcmVwAAAEbAAAAHYAAAB%2FaFGpk3jaTY6xa8JAGMW%2FO62BDi0tJLYQincXEypYIiGJjSgHniQ6umTsUEyLm5BV6NDBP8Tpts6F0v%2Bk%2F0an2i%2BitHDw3v2%2B9%2BDBKTzsJNnWJNTgHEy4BgG3EMI9DCEDOGEXzDADU5hBKMIgNPZqoD3SilVaXZCER3%2FI7AtxEJLtzzuZfI%2BVVkprxTlXShWKb3TBecG11rwoNlmmn1P2WYcJczl32etSpKnziC7lQyWe1smVPy%2FLt7Kc%2B0vWY%2FgAgIIEqAN9we0pwKXreiMasxvabDQMM4riO%2BqxM2ogwDGOZTXxwxDiycQIcoYFBLj5K3EIaSctAq2kTYiw%2Bymhce7vwM9jSqO8JyVd5RH9gyTt2%2BJ%2FyUmYlIR0s04n6%2B7Vm1ozezUeLEaUjhaDSuXHwVRgvLJn1tQ7xiuVv%2FocTRF42mNgZGBgYGbwZOBiAAFGJBIMAAizAFoAAABiAGIAznjaY2BkYGAA4in8zwXi%2BW2%2BMjCzMIDApSwvXzC97Z4Ig8N%2FBxYGZgcgl52BCSQKAA3jCV8CAABfAAAAAAQAAEB42mNgZGBg4f3vACQZQABIMjKgAmYAKEgBXgAAeNpjYGY6wTiBgZWBg2kmUxoDA4MPhGZMYzBi1AHygVLYQUCaawqDA4PChxhmh%2F8ODDEsvAwHgMKMIDnGL0x7gJQCAwMAJd4MFwAAAHjaY2BgYGaA4DAGRgYQkAHyGMF8NgYrIM3JIAGVYYDT%2BAEjAwuDFpBmA9KMDEwMCh9i%2Fv8H8sH0%2F4dQc1iAmAkALaUKLgAAAHjaTY9LDsIgEIbtgqHUPpDi3gPoBVyRTmTddOmqTXThEXqrob2gQ1FjwpDvfwCBdmdXC5AVKFu3e5MfNFJ29KTQT48Ob9%2FlqYwOGZxeUelN2U2R6%2BcArgtCJpauW7UQBqnFkUsjAY%2FkOU1cP%2BDAgvxwn1chZDwUbd6CFimGXwzwF6tPbFIcjEl%2BvvmM%2FbyA48e6tWrKArm4ZJlCbdsrxksL1AwWn%2FyBSJKpYbq8AXaaTb8AAHja28jAwOC00ZrBeQNDQOWO%2F%2FsdBBgYGRiYWYAEELEwMTE4uzo5Zzo5b2BxdnFOcALxNjA6b2ByTswC8jYwg0VlNuoCTWAMqNzMzsoK1rEhNqByEyerg5PMJlYuVueETKcd%2F89uBpnpvIEVomeHLoMsAAe1Id4AAAAAAAB42oWQT07CQBTGv0JBhagk7HQzKxca2sJCE1hDt4QF%2B9JOS0nbaaYDCQfwCJ7Au3AHj%2BLO13FMmm6cl7785vven0kBjHCBhfpYuNa5Ph1c0e2Xu3jEvWG7UdPDLZ4N92nOm%2BEBXuAbHmIMSRMs%2B4aUEd4Nd3CHD8NdvOLTsA2GL8M9PODbcL%2BhD7C1xoaHeLJSEao0FEW14ckxC%2BTU8TxvsY6X0eLPmRhry2WVioLpkrbp84LLQPGI7c6sOiUzpWIWS5GzlSgUzzLBSikOPFTOXqly7rqx0Z1Q5BAIoZBSFihQYQOOBEdkCOgXTOHA07HAGjGWiIjaPZNW13%2F%2Blm6S9FT7rLHFJ6fQbkATOG1j2OFMucKJJsxIVfQORl%2B9Jyda6Sl1dUYhSCm1dyClfoeDve4qMYdLEbfqHf3O%2FAdDumsjAAB42mNgYoAAZQYjBmyAGYQZmdhL8zLdDEydARfoAqIAAAABAAMABwAKABMAB%2F%2F%2FAA8AAQAAAAAAAAAAAAAAAAABAAAAAA%3D%3D%29%20format%28%27woff%27%29%3B%0A%7D%0Abody%20%7B%0A%2Dwebkit%2Dtext%2Dsize%2Dadjust%3A%20100%25%3B%0Atext%2Dsize%2Dadjust%3A%20100%25%3B%0Acolor%3A%20%23333%3B%0Afont%2Dfamily%3A%20%22Helvetica%20Neue%22%2C%20Helvetica%2C%20%22Segoe%20UI%22%2C%20Arial%2C%20freesans%2C%20sans%2Dserif%2C%20%22Apple%20Color%20Emoji%22%2C%20%22Segoe%20UI%20Emoji%22%2C%20%22Segoe%20UI%20Symbol%22%3B%0Afont%2Dsize%3A%2016px%3B%0Aline%2Dheight%3A%201%2E6%3B%0Aword%2Dwrap%3A%20break%2Dword%3B%0A%7D%0Aa%20%7B%0Abackground%2Dcolor%3A%20transparent%3B%0A%7D%0Aa%3Aactive%2C%0Aa%3Ahover%20%7B%0Aoutline%3A%200%3B%0A%7D%0Astrong%20%7B%0Afont%2Dweight%3A%20bold%3B%0A%7D%0Ah1%20%7B%0Afont%2Dsize%3A%202em%3B%0Amargin%3A%200%2E67em%200%3B%0A%7D%0Aimg%20%7B%0Aborder%3A%200%3B%0A%7D%0Ahr%20%7B%0Abox%2Dsizing%3A%20content%2Dbox%3B%0Aheight%3A%200%3B%0A%7D%0Apre%20%7B%0Aoverflow%3A%20auto%3B%0A%7D%0Acode%2C%0Akbd%2C%0Apre%20%7B%0Afont%2Dfamily%3A%20monospace%2C%20monospace%3B%0Afont%2Dsize%3A%201em%3B%0A%7D%0Ainput%20%7B%0Acolor%3A%20inherit%3B%0Afont%3A%20inherit%3B%0Amargin%3A%200%3B%0A%7D%0Ahtml%20input%5Bdisabled%5D%20%7B%0Acursor%3A%20default%3B%0A%7D%0Ainput%20%7B%0Aline%2Dheight%3A%20normal%3B%0A%7D%0Ainput%5Btype%3D%22checkbox%22%5D%20%7B%0Abox%2Dsizing%3A%20border%2Dbox%3B%0Apadding%3A%200%3B%0A%7D%0Atable%20%7B%0Aborder%2Dcollapse%3A%20collapse%3B%0Aborder%2Dspacing%3A%200%3B%0A%7D%0Atd%2C%0Ath%20%7B%0Apadding%3A%200%3B%0A%7D%0A%2A%20%7B%0Abox%2Dsizing%3A%20border%2Dbox%3B%0A%7D%0Ainput%20%7B%0Afont%3A%2013px%20%2F%201%2E4%20Helvetica%2C%20arial%2C%20nimbussansl%2C%20liberationsans%2C%20freesans%2C%20clean%2C%20sans%2Dserif%2C%20%22Apple%20Color%20Emoji%22%2C%20%22Segoe%20UI%20Emoji%22%2C%20%22Segoe%20UI%20Symbol%22%3B%0A%7D%0Aa%20%7B%0Acolor%3A%20%234078c0%3B%0Atext%2Ddecoration%3A%20none%3B%0A%7D%0Aa%3Ahover%2C%0Aa%3Aactive%20%7B%0Atext%2Ddecoration%3A%20underline%3B%0A%7D%0Ahr%20%7B%0Aheight%3A%200%3B%0Amargin%3A%2015px%200%3B%0Aoverflow%3A%20hidden%3B%0Abackground%3A%20transparent%3B%0Aborder%3A%200%3B%0Aborder%2Dbottom%3A%201px%20solid%20%23ddd%3B%0A%7D%0Ahr%3Abefore%20%7B%0Adisplay%3A%20table%3B%0Acontent%3A%20%22%22%3B%0A%7D%0Ahr%3Aafter%20%7B%0Adisplay%3A%20table%3B%0Aclear%3A%20both%3B%0Acontent%3A%20%22%22%3B%0A%7D%0Ah1%2C%0Ah2%2C%0Ah3%2C%0Ah4%2C%0Ah5%2C%0Ah6%20%7B%0Amargin%2Dtop%3A%2015px%3B%0Amargin%2Dbottom%3A%2015px%3B%0Aline%2Dheight%3A%201%2E1%3B%0A%7D%0Ah1%20%7B%0Afont%2Dsize%3A%2030px%3B%0A%7D%0Ah2%20%7B%0Afont%2Dsize%3A%2021px%3B%0A%7D%0Ah3%20%7B%0Afont%2Dsize%3A%2016px%3B%0A%7D%0Ah4%20%7B%0Afont%2Dsize%3A%2014px%3B%0A%7D%0Ah5%20%7B%0Afont%2Dsize%3A%2012px%3B%0A%7D%0Ah6%20%7B%0Afont%2Dsize%3A%2011px%3B%0A%7D%0Ablockquote%20%7B%0Amargin%3A%200%3B%0A%7D%0Aul%2C%0Aol%20%7B%0Apadding%3A%200%3B%0Amargin%2Dtop%3A%200%3B%0Amargin%2Dbottom%3A%200%3B%0A%7D%0Aol%20ol%2C%0Aul%20ol%20%7B%0Alist%2Dstyle%2Dtype%3A%20lower%2Droman%3B%0A%7D%0Aul%20ul%20ol%2C%0Aul%20ol%20ol%2C%0Aol%20ul%20ol%2C%0Aol%20ol%20ol%20%7B%0Alist%2Dstyle%2Dtype%3A%20lower%2Dalpha%3B%0A%7D%0Add%20%7B%0Amargin%2Dleft%3A%200%3B%0A%7D%0Acode%20%7B%0Afont%2Dfamily%3A%20Consolas%2C%20%22Liberation%20Mono%22%2C%20Menlo%2C%20Courier%2C%20monospace%3B%0Afont%2Dsize%3A%2012px%3B%0A%7D%0Apre%20%7B%0Amargin%2Dtop%3A%200%3B%0Amargin%2Dbottom%3A%200%3B%0Afont%3A%2012px%20Consolas%2C%20%22Liberation%20Mono%22%2C%20Menlo%2C%20Courier%2C%20monospace%3B%0A%7D%0A%2Eselect%3A%3A%2Dms%2Dexpand%20%7B%0Aopacity%3A%200%3B%0A%7D%0A%2Eocticon%20%7B%0Afont%3A%20normal%20normal%20normal%2016px%2F1%20octicons%2Dlink%3B%0Adisplay%3A%20inline%2Dblock%3B%0Atext%2Ddecoration%3A%20none%3B%0Atext%2Drendering%3A%20auto%3B%0A%2Dwebkit%2Dfont%2Dsmoothing%3A%20antialiased%3B%0A%2Dmoz%2Dosx%2Dfont%2Dsmoothing%3A%20grayscale%3B%0A%2Dwebkit%2Duser%2Dselect%3A%20none%3B%0A%2Dmoz%2Duser%2Dselect%3A%20none%3B%0A%2Dms%2Duser%2Dselect%3A%20none%3B%0Auser%2Dselect%3A%20none%3B%0A%7D%0A%2Eocticon%2Dlink%3Abefore%20%7B%0Acontent%3A%20%27%5Cf05c%27%3B%0A%7D%0A%2Emarkdown%2Dbody%3Abefore%20%7B%0Adisplay%3A%20table%3B%0Acontent%3A%20%22%22%3B%0A%7D%0A%2Emarkdown%2Dbody%3Aafter%20%7B%0Adisplay%3A%20table%3B%0Aclear%3A%20both%3B%0Acontent%3A%20%22%22%3B%0A%7D%0A%2Emarkdown%2Dbody%3E%2A%3Afirst%2Dchild%20%7B%0Amargin%2Dtop%3A%200%20%21important%3B%0A%7D%0A%2Emarkdown%2Dbody%3E%2A%3Alast%2Dchild%20%7B%0Amargin%2Dbottom%3A%200%20%21important%3B%0A%7D%0Aa%3Anot%28%5Bhref%5D%29%20%7B%0Acolor%3A%20inherit%3B%0Atext%2Ddecoration%3A%20none%3B%0A%7D%0A%2Eanchor%20%7B%0Adisplay%3A%20inline%2Dblock%3B%0Apadding%2Dright%3A%202px%3B%0Amargin%2Dleft%3A%20%2D18px%3B%0A%7D%0A%2Eanchor%3Afocus%20%7B%0Aoutline%3A%20none%3B%0A%7D%0Ah1%2C%0Ah2%2C%0Ah3%2C%0Ah4%2C%0Ah5%2C%0Ah6%20%7B%0Amargin%2Dtop%3A%201em%3B%0Amargin%2Dbottom%3A%2016px%3B%0Afont%2Dweight%3A%20bold%3B%0Aline%2Dheight%3A%201%2E4%3B%0A%7D%0Ah1%20%2Eocticon%2Dlink%2C%0Ah2%20%2Eocticon%2Dlink%2C%0Ah3%20%2Eocticon%2Dlink%2C%0Ah4%20%2Eocticon%2Dlink%2C%0Ah5%20%2Eocticon%2Dlink%2C%0Ah6%20%2Eocticon%2Dlink%20%7B%0Acolor%3A%20%23000%3B%0Avertical%2Dalign%3A%20middle%3B%0Avisibility%3A%20hidden%3B%0A%7D%0Ah1%3Ahover%20%2Eanchor%2C%0Ah2%3Ahover%20%2Eanchor%2C%0Ah3%3Ahover%20%2Eanchor%2C%0Ah4%3Ahover%20%2Eanchor%2C%0Ah5%3Ahover%20%2Eanchor%2C%0Ah6%3Ahover%20%2Eanchor%20%7B%0Atext%2Ddecoration%3A%20none%3B%0A%7D%0Ah1%3Ahover%20%2Eanchor%20%2Eocticon%2Dlink%2C%0Ah2%3Ahover%20%2Eanchor%20%2Eocticon%2Dlink%2C%0Ah3%3Ahover%20%2Eanchor%20%2Eocticon%2Dlink%2C%0Ah4%3Ahover%20%2Eanchor%20%2Eocticon%2Dlink%2C%0Ah5%3Ahover%20%2Eanchor%20%2Eocticon%2Dlink%2C%0Ah6%3Ahover%20%2Eanchor%20%2Eocticon%2Dlink%20%7B%0Avisibility%3A%20visible%3B%0A%7D%0Ah1%20%7B%0Apadding%2Dbottom%3A%200%2E3em%3B%0Afont%2Dsize%3A%202%2E25em%3B%0Aline%2Dheight%3A%201%2E2%3B%0Aborder%2Dbottom%3A%201px%20solid%20%23eee%3B%0A%7D%0Ah1%20%2Eanchor%20%7B%0Aline%2Dheight%3A%201%3B%0A%7D%0Ah2%20%7B%0Apadding%2Dbottom%3A%200%2E3em%3B%0Afont%2Dsize%3A%201%2E75em%3B%0Aline%2Dheight%3A%201%2E225%3B%0Aborder%2Dbottom%3A%201px%20solid%20%23eee%3B%0A%7D%0Ah2%20%2Eanchor%20%7B%0Aline%2Dheight%3A%201%3B%0A%7D%0Ah3%20%7B%0Afont%2Dsize%3A%201%2E5em%3B%0Aline%2Dheight%3A%201%2E43%3B%0A%7D%0Ah3%20%2Eanchor%20%7B%0Aline%2Dheight%3A%201%2E2%3B%0A%7D%0Ah4%20%7B%0Afont%2Dsize%3A%201%2E25em%3B%0A%7D%0Ah4%20%2Eanchor%20%7B%0Aline%2Dheight%3A%201%2E2%3B%0A%7D%0Ah5%20%7B%0Afont%2Dsize%3A%201em%3B%0A%7D%0Ah5%20%2Eanchor%20%7B%0Aline%2Dheight%3A%201%2E1%3B%0A%7D%0Ah6%20%7B%0Afont%2Dsize%3A%201em%3B%0Acolor%3A%20%23777%3B%0A%7D%0Ah6%20%2Eanchor%20%7B%0Aline%2Dheight%3A%201%2E1%3B%0A%7D%0Ap%2C%0Ablockquote%2C%0Aul%2C%0Aol%2C%0Adl%2C%0Atable%2C%0Apre%20%7B%0Amargin%2Dtop%3A%200%3B%0Amargin%2Dbottom%3A%2016px%3B%0A%7D%0Ahr%20%7B%0Aheight%3A%204px%3B%0Apadding%3A%200%3B%0Amargin%3A%2016px%200%3B%0Abackground%2Dcolor%3A%20%23e7e7e7%3B%0Aborder%3A%200%20none%3B%0A%7D%0Aul%2C%0Aol%20%7B%0Apadding%2Dleft%3A%202em%3B%0A%7D%0Aul%20ul%2C%0Aul%20ol%2C%0Aol%20ol%2C%0Aol%20ul%20%7B%0Amargin%2Dtop%3A%200%3B%0Amargin%2Dbottom%3A%200%3B%0A%7D%0Ali%3Ep%20%7B%0Amargin%2Dtop%3A%2016px%3B%0A%7D%0Adl%20%7B%0Apadding%3A%200%3B%0A%7D%0Adl%20dt%20%7B%0Apadding%3A%200%3B%0Amargin%2Dtop%3A%2016px%3B%0Afont%2Dsize%3A%201em%3B%0Afont%2Dstyle%3A%20italic%3B%0Afont%2Dweight%3A%20bold%3B%0A%7D%0Adl%20dd%20%7B%0Apadding%3A%200%2016px%3B%0Amargin%2Dbottom%3A%2016px%3B%0A%7D%0Ablockquote%20%7B%0Apadding%3A%200%2015px%3B%0Acolor%3A%20%23777%3B%0Aborder%2Dleft%3A%204px%20solid%20%23ddd%3B%0A%7D%0Ablockquote%3E%3Afirst%2Dchild%20%7B%0Amargin%2Dtop%3A%200%3B%0A%7D%0Ablockquote%3E%3Alast%2Dchild%20%7B%0Amargin%2Dbottom%3A%200%3B%0A%7D%0Atable%20%7B%0Adisplay%3A%20block%3B%0Awidth%3A%20100%25%3B%0Aoverflow%3A%20auto%3B%0Aword%2Dbreak%3A%20normal%3B%0Aword%2Dbreak%3A%20keep%2Dall%3B%0A%7D%0Atable%20th%20%7B%0Afont%2Dweight%3A%20bold%3B%0A%7D%0Atable%20th%2C%0Atable%20td%20%7B%0Apadding%3A%206px%2013px%3B%0Aborder%3A%201px%20solid%20%23ddd%3B%0A%7D%0Atable%20tr%20%7B%0Abackground%2Dcolor%3A%20%23fff%3B%0Aborder%2Dtop%3A%201px%20solid%20%23ccc%3B%0A%7D%0Atable%20tr%3Anth%2Dchild%282n%29%20%7B%0Abackground%2Dcolor%3A%20%23f8f8f8%3B%0A%7D%0Aimg%20%7B%0Amax%2Dwidth%3A%20100%25%3B%0Abox%2Dsizing%3A%20content%2Dbox%3B%0Abackground%2Dcolor%3A%20%23fff%3B%0A%7D%0Acode%20%7B%0Apadding%3A%200%3B%0Apadding%2Dtop%3A%200%2E2em%3B%0Apadding%2Dbottom%3A%200%2E2em%3B%0Amargin%3A%200%3B%0Afont%2Dsize%3A%2085%25%3B%0Abackground%2Dcolor%3A%20rgba%280%2C0%2C0%2C0%2E04%29%3B%0Aborder%2Dradius%3A%203px%3B%0A%7D%0Acode%3Abefore%2C%0Acode%3Aafter%20%7B%0Aletter%2Dspacing%3A%20%2D0%2E2em%3B%0Acontent%3A%20%22%5C00a0%22%3B%0A%7D%0Apre%3Ecode%20%7B%0Apadding%3A%200%3B%0Amargin%3A%200%3B%0Afont%2Dsize%3A%20100%25%3B%0Aword%2Dbreak%3A%20normal%3B%0Awhite%2Dspace%3A%20pre%3B%0Abackground%3A%20transparent%3B%0Aborder%3A%200%3B%0A%7D%0A%2Ehighlight%20%7B%0Amargin%2Dbottom%3A%2016px%3B%0A%7D%0A%2Ehighlight%20pre%2C%0Apre%20%7B%0Apadding%3A%2016px%3B%0Aoverflow%3A%20auto%3B%0Afont%2Dsize%3A%2085%25%3B%0Aline%2Dheight%3A%201%2E45%3B%0Abackground%2Dcolor%3A%20%23f7f7f7%3B%0Aborder%2Dradius%3A%203px%3B%0A%7D%0A%2Ehighlight%20pre%20%7B%0Amargin%2Dbottom%3A%200%3B%0Aword%2Dbreak%3A%20normal%3B%0A%7D%0Apre%20%7B%0Aword%2Dwrap%3A%20normal%3B%0A%7D%0Apre%20code%20%7B%0Adisplay%3A%20inline%3B%0Amax%2Dwidth%3A%20initial%3B%0Apadding%3A%200%3B%0Amargin%3A%200%3B%0Aoverflow%3A%20initial%3B%0Aline%2Dheight%3A%20inherit%3B%0Aword%2Dwrap%3A%20normal%3B%0Abackground%2Dcolor%3A%20transparent%3B%0Aborder%3A%200%3B%0A%7D%0Apre%20code%3Abefore%2C%0Apre%20code%3Aafter%20%7B%0Acontent%3A%20normal%3B%0A%7D%0Akbd%20%7B%0Adisplay%3A%20inline%2Dblock%3B%0Apadding%3A%203px%205px%3B%0Afont%2Dsize%3A%2011px%3B%0Aline%2Dheight%3A%2010px%3B%0Acolor%3A%20%23555%3B%0Avertical%2Dalign%3A%20middle%3B%0Abackground%2Dcolor%3A%20%23fcfcfc%3B%0Aborder%3A%20solid%201px%20%23ccc%3B%0Aborder%2Dbottom%2Dcolor%3A%20%23bbb%3B%0Aborder%2Dradius%3A%203px%3B%0Abox%2Dshadow%3A%20inset%200%20%2D1px%200%20%23bbb%3B%0A%7D%0A%2Epl%2Dc%20%7B%0Acolor%3A%20%23969896%3B%0A%7D%0A%2Epl%2Dc1%2C%0A%2Epl%2Ds%20%2Epl%2Dv%20%7B%0Acolor%3A%20%230086b3%3B%0A%7D%0A%2Epl%2De%2C%0A%2Epl%2Den%20%7B%0Acolor%3A%20%23795da3%3B%0A%7D%0A%2Epl%2Ds%20%2Epl%2Ds1%2C%0A%2Epl%2Dsmi%20%7B%0Acolor%3A%20%23333%3B%0A%7D%0A%2Epl%2Dent%20%7B%0Acolor%3A%20%2363a35c%3B%0A%7D%0A%2Epl%2Dk%20%7B%0Acolor%3A%20%23a71d5d%3B%0A%7D%0A%2Epl%2Dpds%2C%0A%2Epl%2Ds%2C%0A%2Epl%2Ds%20%2Epl%2Dpse%20%2Epl%2Ds1%2C%0A%2Epl%2Dsr%2C%0A%2Epl%2Dsr%20%2Epl%2Dcce%2C%0A%2Epl%2Dsr%20%2Epl%2Dsra%2C%0A%2Epl%2Dsr%20%2Epl%2Dsre%20%7B%0Acolor%3A%20%23183691%3B%0A%7D%0A%2Epl%2Dv%20%7B%0Acolor%3A%20%23ed6a43%3B%0A%7D%0A%2Epl%2Did%20%7B%0Acolor%3A%20%23b52a1d%3B%0A%7D%0A%2Epl%2Dii%20%7B%0Abackground%2Dcolor%3A%20%23b52a1d%3B%0Acolor%3A%20%23f8f8f8%3B%0A%7D%0A%2Epl%2Dsr%20%2Epl%2Dcce%20%7B%0Acolor%3A%20%2363a35c%3B%0Afont%2Dweight%3A%20bold%3B%0A%7D%0A%2Epl%2Dml%20%7B%0Acolor%3A%20%23693a17%3B%0A%7D%0A%2Epl%2Dmh%2C%0A%2Epl%2Dmh%20%2Epl%2Den%2C%0A%2Epl%2Dms%20%7B%0Acolor%3A%20%231d3e81%3B%0Afont%2Dweight%3A%20bold%3B%0A%7D%0A%2Epl%2Dmq%20%7B%0Acolor%3A%20%23008080%3B%0A%7D%0A%2Epl%2Dmi%20%7B%0Acolor%3A%20%23333%3B%0Afont%2Dstyle%3A%20italic%3B%0A%7D%0A%2Epl%2Dmb%20%7B%0Acolor%3A%20%23333%3B%0Afont%2Dweight%3A%20bold%3B%0A%7D%0A%2Epl%2Dmd%20%7B%0Abackground%2Dcolor%3A%20%23ffecec%3B%0Acolor%3A%20%23bd2c00%3B%0A%7D%0A%2Epl%2Dmi1%20%7B%0Abackground%2Dcolor%3A%20%23eaffea%3B%0Acolor%3A%20%2355a532%3B%0A%7D%0A%2Epl%2Dmdr%20%7B%0Acolor%3A%20%23795da3%3B%0Afont%2Dweight%3A%20bold%3B%0A%7D%0A%2Epl%2Dmo%20%7B%0Acolor%3A%20%231d3e81%3B%0A%7D%0Akbd%20%7B%0Adisplay%3A%20inline%2Dblock%3B%0Apadding%3A%203px%205px%3B%0Afont%3A%2011px%20Consolas%2C%20%22Liberation%20Mono%22%2C%20Menlo%2C%20Courier%2C%20monospace%3B%0Aline%2Dheight%3A%2010px%3B%0Acolor%3A%20%23555%3B%0Avertical%2Dalign%3A%20middle%3B%0Abackground%2Dcolor%3A%20%23fcfcfc%3B%0Aborder%3A%20solid%201px%20%23ccc%3B%0Aborder%2Dbottom%2Dcolor%3A%20%23bbb%3B%0Aborder%2Dradius%3A%203px%3B%0Abox%2Dshadow%3A%20inset%200%20%2D1px%200%20%23bbb%3B%0A%7D%0A%2Etask%2Dlist%2Ditem%20%7B%0Alist%2Dstyle%2Dtype%3A%20none%3B%0A%7D%0A%2Etask%2Dlist%2Ditem%2B%2Etask%2Dlist%2Ditem%20%7B%0Amargin%2Dtop%3A%203px%3B%0A%7D%0A%2Etask%2Dlist%2Ditem%20input%20%7B%0Amargin%3A%200%200%2E35em%200%2E25em%20%2D1%2E6em%3B%0Avertical%2Dalign%3A%20middle%3B%0A%7D%0A%3Achecked%2B%2Eradio%2Dlabel%20%7B%0Az%2Dindex%3A%201%3B%0Aposition%3A%20relative%3B%0Aborder%2Dcolor%3A%20%234078c0%3B%0A%7D%0A%2EsourceLine%20%7B%0Adisplay%3A%20inline%2Dblock%3B%0A%7D%0Acode%20%2Ekw%20%7B%20color%3A%20%23000000%3B%20%7D%0Acode%20%2Edt%20%7B%20color%3A%20%23ed6a43%3B%20%7D%0Acode%20%2Edv%20%7B%20color%3A%20%23009999%3B%20%7D%0Acode%20%2Ebn%20%7B%20color%3A%20%23009999%3B%20%7D%0Acode%20%2Efl%20%7B%20color%3A%20%23009999%3B%20%7D%0Acode%20%2Ech%20%7B%20color%3A%20%23009999%3B%20%7D%0Acode%20%2Est%20%7B%20color%3A%20%23183691%3B%20%7D%0Acode%20%2Eco%20%7B%20color%3A%20%23969896%3B%20%7D%0Acode%20%2Eot%20%7B%20color%3A%20%230086b3%3B%20%7D%0Acode%20%2Eal%20%7B%20color%3A%20%23a61717%3B%20%7D%0Acode%20%2Efu%20%7B%20color%3A%20%2363a35c%3B%20%7D%0Acode%20%2Eer%20%7B%20color%3A%20%23a61717%3B%20background%2Dcolor%3A%20%23e3d2d2%3B%20%7D%0Acode%20%2Ewa%20%7B%20color%3A%20%23000000%3B%20%7D%0Acode%20%2Ecn%20%7B%20color%3A%20%23008080%3B%20%7D%0Acode%20%2Esc%20%7B%20color%3A%20%23008080%3B%20%7D%0Acode%20%2Evs%20%7B%20color%3A%20%23183691%3B%20%7D%0Acode%20%2Ess%20%7B%20color%3A%20%23183691%3B%20%7D%0Acode%20%2Eim%20%7B%20color%3A%20%23000000%3B%20%7D%0Acode%20%2Eva%20%7Bcolor%3A%20%23008080%3B%20%7D%0Acode%20%2Ecf%20%7B%20color%3A%20%23000000%3B%20%7D%0Acode%20%2Eop%20%7B%20color%3A%20%23000000%3B%20%7D%0Acode%20%2Ebu%20%7B%20color%3A%20%23000000%3B%20%7D%0Acode%20%2Eex%20%7B%20color%3A%20%23000000%3B%20%7D%0Acode%20%2Epp%20%7B%20color%3A%20%23999999%3B%20%7D%0Acode%20%2Eat%20%7B%20color%3A%20%23008080%3B%20%7D%0Acode%20%2Edo%20%7B%20color%3A%20%23969896%3B%20%7D%0Acode%20%2Ean%20%7B%20color%3A%20%23008080%3B%20%7D%0Acode%20%2Ecv%20%7B%20color%3A%20%23008080%3B%20%7D%0Acode%20%2Ein%20%7B%20color%3A%20%23008080%3B%20%7D%0A" rel="stylesheet">
<style>
body {
box-sizing: border-box;
min-width: 200px;
max-width: 980px;
margin: 0 auto;
padding: 45px;
padding-top: 0px;
}
</style>
</head>
<body>
<h2 id="pkr-shiny">pkr Shiny</h2>
<p><a href="https://opensource.org/licenses/mit-license.php"> <img alt="MIT Licence" src="data:image/svg+xml;base64,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" /> </a> <a href="https://github.com/ellerbrock/open-source-badge/"> <img alt="Open Source Love" src="data:image/svg+xml;base64,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" /> </a></p>
<ul>
<li><code>pkr Shiny</code> <a href="https://asan.shinyapps.io/pkrshiny" class="uri">https://asan.shinyapps.io/pkrshiny</a></li>
<li><code>pkr Shiny</code> is open to everyone. We are happy to take your input. Please fork the repo, modify the codes and submit a pull request. <a href="https://github.com/asancpt/pkrshiny" class="uri">https://github.com/asancpt/pkrshiny</a></li>
<li>We are actively developing R pacakges, Shiny Apps, and Edison Science Apps regarding clinical pharmacology and pharmacometrics. Please check here. <a href="https://asancpt.github.io/softwares" class="uri">https://asancpt.github.io/softwares</a></li>
</ul>
<h3 id="installation-of-pkr-r-package">Installation of pkr R Package</h3>
<div class="sourceCode"><pre class="sourceCode r"><code class="sourceCode r"><span class="kw">install.packages</span>(<span class="st">"pkr"</span>)
<span class="kw">library</span>(pkr)
<span class="kw">NCA</span>(Theoph, <span class="st">"Subject"</span>, <span class="st">"Time"</span>, <span class="st">"conc"</span>, <span class="dt">dose=</span><span class="dv">320</span>, <span class="dt">uConc=</span><span class="st">"mg/L"</span>)</code></pre></div>
<h3 id="help">Help</h3>
<ul>
<li><code>pkr</code> package help <a href="https://cran.r-project.org/web/packages/pkr/pkr.pdf" class="uri">https://cran.r-project.org/web/packages/pkr/pkr.pdf</a></li>
</ul>
<h3 id="dataset">Dataset</h3>
<ul>
<li><code>Theoph</code>: Oral 320 mg (N=12) <a href="http://stat.ethz.ch/R-manual/R-devel/library/datasets/html/Theoph.html" class="uri">http://stat.ethz.ch/R-manual/R-devel/library/datasets/html/Theoph.html</a></li>
<li><code>Indometh</code>: IV 25 mg (N=6) <a href="http://stat.ethz.ch/R-manual/R-devel/library/datasets/html/Indometh.html" class="uri">http://stat.ethz.ch/R-manual/R-devel/library/datasets/html/Indometh.html</a></li>
<li><code>sd_oral_richpk</code>: Oral 5000mg (N=50) <a href="https://github.com/dpastoor/PKPDdatasets" class="uri">https://github.com/dpastoor/PKPDdatasets</a></li>
<li><code>sd_iv_rich_pkpd</code>: IV diverse dosing (N=60) <a href="https://github.com/dpastoor/PKPDdatasets" class="uri">https://github.com/dpastoor/PKPDdatasets</a></li>
</ul>
<h3 id="cdisc-materials">CDISC materials</h3>
<ul>
<li><a href="https://www.cdisc.org/sites/default/files/members/standard/foundational/sdtmig/sdtmig_20v3.2_20noportfolio.pdf">CDISC SDTM Implementation Guide 3.2 PDF</a></li>
<li><a href="https://evs.nci.nih.gov/ftp1/CDISC/SDTM/SDTM%20Terminology.pdf">CDISC Terminology PDF</a></li>
</ul>
<h3 id="references">References</h3>
<p>Gabrielsson J, Weiner D. Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications. 5th ed. 2016.</p>
<p>Shargel L, Yu A. Applied Biopharmaceutics and Pharmacokinetics. 7th ed. 2015.</p>
<p>Rowland M, Tozer TN. Clinical Pharmacokinetics and Pharmacodynamics - Concepts and Applications. 4th ed. 2011.</p>
<p>Gibaldi M, Perrier D. Pharmacokinetics. 2nd ed. revised and expanded. 1982.</p>
<h3 id="bibliography-of-r-packages">Bibliography of R packages</h3>
<pre><code>## Error in lapply(X = X, FUN = FUN, ...): object 'MyLib' not found</code></pre>
<h3 id="session-information">Session information</h3>
<pre><code>## ─ Session info ───────────────────────────────────────────────────────────────
## setting value
## version R version 3.6.3 (2020-02-29)
## os Ubuntu 18.04.4 LTS
## system x86_64, linux-gnu
## ui X11
## language (EN)
## collate C.UTF-8
## ctype C.UTF-8
## tz Etc/UTC
## date 2020-03-12
##
## ─ Packages ───────────────────────────────────────────────────────────────────
## package * version date lib source
## assertthat 0.2.1 2019-03-21 [2] CRAN (R 3.6.3)
## backports 1.1.5 2019-10-02 [2] CRAN (R 3.6.3)
## callr 3.4.2 2020-02-12 [2] CRAN (R 3.6.3)
## cli 2.0.2 2020-02-28 [2] CRAN (R 3.6.3)
## crayon 1.3.4 2017-09-16 [2] CRAN (R 3.6.3)
## desc 1.2.0 2018-05-01 [2] CRAN (R 3.6.3)
## devtools 2.2.2 2020-02-17 [1] CRAN (R 3.6.3)
## digest 0.6.25 2020-02-23 [2] CRAN (R 3.6.3)
## ellipsis 0.3.0 2019-09-20 [2] CRAN (R 3.6.3)
## evaluate 0.14 2019-05-28 [2] CRAN (R 3.6.3)
## fansi 0.4.1 2020-01-08 [2] CRAN (R 3.6.3)
## fs 1.3.2 2020-03-05 [2] CRAN (R 3.6.3)
## glue 1.3.1 2019-03-12 [2] CRAN (R 3.6.3)
## htmltools 0.4.0 2019-10-04 [2] CRAN (R 3.6.3)
## knitr 1.28 2020-02-06 [2] CRAN (R 3.6.3)
## magrittr 1.5 2014-11-22 [2] CRAN (R 3.6.3)
## memoise 1.1.0 2017-04-21 [2] CRAN (R 3.6.3)
## pkgbuild 1.0.6 2019-10-09 [2] CRAN (R 3.6.3)
## pkgload 1.0.2 2018-10-29 [2] CRAN (R 3.6.3)
## prettyunits 1.1.1 2020-01-24 [2] CRAN (R 3.6.3)
## processx 3.4.2 2020-02-09 [2] CRAN (R 3.6.3)
## ps 1.3.2 2020-02-13 [2] CRAN (R 3.6.3)
## R6 2.4.1 2019-11-12 [2] CRAN (R 3.6.3)
## Rcpp 1.0.3 2019-11-08 [2] CRAN (R 3.6.3)
## remotes 2.1.1 2020-02-15 [1] CRAN (R 3.6.3)
## rlang 0.4.5 2020-03-01 [2] CRAN (R 3.6.3)
## rmarkdown 2.1 2020-01-20 [2] CRAN (R 3.6.3)
## rprojroot 1.3-2 2018-01-03 [2] CRAN (R 3.6.3)
## sessioninfo 1.1.1 2018-11-05 [1] CRAN (R 3.6.3)
## stringi 1.4.6 2020-02-17 [2] CRAN (R 3.6.3)
## stringr 1.4.0 2019-02-10 [2] CRAN (R 3.6.3)
## testthat 2.3.2 2020-03-02 [2] CRAN (R 3.6.3)
## usethis 1.5.1 2019-07-04 [1] CRAN (R 3.6.3)
## withr 2.1.2 2018-03-15 [2] CRAN (R 3.6.3)
## xfun 0.12 2020-01-13 [2] CRAN (R 3.6.3)
##
## [1] /home/ubuntu/R/x86_64-pc-linux-gnu-library/3.6
## [2] /usr/local/lib/R/site-library
## [3] /usr/lib/R/site-library
## [4] /usr/lib/R/library</code></pre>
</body>
</html>