diff --git a/vast_post_processing/cli/vast_post_processing.py b/vast_post_processing/cli/vast_post_processing.py
index 8fda590..3b4f003 100644
--- a/vast_post_processing/cli/vast_post_processing.py
+++ b/vast_post_processing/cli/vast_post_processing.py
@@ -80,6 +80,9 @@ def main(
     compress: Optional[bool] = typer.Option(
         None, help=("Compress all processed FITS files")
     ),
+    compress_quant: Optional[int] = typer.Option(
+        None, help=("Compression quantisation to use, if compressing.")
+    ),
     directory_suffix: Optional[str] = typer.Option(
         None, help=("Suffix to use for processed data directories. For "
                     "example, passing 'PROCESSED' results in images being "
@@ -116,6 +119,7 @@ def main(
         crop_size,
         create_moc,
         compress,
+        compress_quant,
         directory_suffix,
         cat_extension,
         fits_extension,
diff --git a/vast_post_processing/core.py b/vast_post_processing/core.py
index 58422db..82f01bf 100644
--- a/vast_post_processing/core.py
+++ b/vast_post_processing/core.py
@@ -147,6 +147,7 @@ def setup_configuration(
     crop_size: Optional[float] = None,
     create_moc: Optional[bool] = None,
     compress: Optional[bool] = None,
+    compress_quant: Optional[int] = None,
     directory_suffix: Optional[str] = None,
     cat_extension: Optional[str] = None,
     fits_extension: Optional[str] = None,
@@ -161,6 +162,7 @@ def setup_configuration(
     u.Quantity,
     bool,
     bool,
+    int,
     str,
     str,
     str,
@@ -192,6 +194,8 @@ def setup_configuration(
         Flag to create MOCs, by default None.
     compress : Optional[bool], optional
         Flag to compress files, by default None.
+    compress_quant : Optional[int], optional
+        Compression quantisation level to use, by default None.
     directory_suffix : Optional[str], optional
         Suffix to use for processed data directories (for example
         `STOKESI_IMAGES_PROCESSED`), by default None.
@@ -239,6 +243,7 @@ def setup_configuration(
         "crop_size": crop_size,
         "create_moc": create_moc,
         "compress": compress,
+        "compress_quant": compress_quant,
         "directory_suffix": directory_suffix,
         "cat_extension": cat_extension,
         "fits_extension": fits_extension,
@@ -468,6 +473,7 @@ def crop_image(
     corrected_fits: list[Union[fits.PrimaryHDU, fits.HDUList]],
     crop_size: u.Quantity,
     compress: bool,
+    compress_quant: int,
     overwrite: bool,
     verbose: bool,
     debug: bool,
@@ -494,6 +500,8 @@ def crop_image(
         Angular size of crop to be applied.
     compress : bool
         Flag to compress image data.
+    compress_quant : int
+        Compression quantisation to use.
     overwrite : bool
         Flag to overwrite image data.
     verbose : bool
@@ -544,7 +552,12 @@ def crop_image(
         cropped_hdu = crop.crop_hdu(image_hdu, field_centre, size=crop_size)
 
         # Compress image if requested
-        processed_hdu = compress_hdu(cropped_hdu) if compress else cropped_hdu
+        if compress:
+            processed_hdu = compress_hdu(cropped_hdu,
+                                         quantize_level=compress_quant
+                                         )
+        else:
+            processed_hdu = cropped_hdu
         fitsutils.update_header_history(processed_hdu.header)
 
         if hdul is not None:
@@ -729,6 +742,7 @@ def run(
     crop_size: Optional[float] = None,
     create_moc: Optional[bool] = None,
     compress: Optional[bool] = None,
+    compress_quant: Optional[int] = None,
     directory_suffix: Optional[str] = None,
     cat_extension: Optional[str] = None,
     fits_extension: Optional[str] = None,
@@ -760,6 +774,8 @@ def run(
         Flag to create MOCs, by default None.
     compress : Optional[bool], optional
         Flag to compress files, by default None.
+    compress_quant : Optional[int], optional
+        Compression quantisation to use, by default None.
     directory_suffix : Optional[str], optional
         Suffix to use for processed data directories (for example
         `STOKESI_IMAGES_PROCESSED`), by default None.
@@ -786,6 +802,7 @@ def run(
         crop_size,
         create_moc,
         compress,
+        compress_quant,
         directory_suffix,
         cat_extension,
         fits_extension,
@@ -802,6 +819,7 @@ def run(
         crop_size=crop_size,
         create_moc=create_moc,
         compress=compress,
+        compress_quant=compress_quant,
         directory_suffix=directory_suffix,
         cat_extension=cat_extension,
         fits_extension=fits_extension,
@@ -892,6 +910,7 @@ def run(
             verbose=verbose,
             debug=debug,
             compress=compress,
+            compress_quant=compress_quant,
             processed_dir_suffix=directory_suffix,
         )
         if type(cropped_hdu) == fits.HDUList:
diff --git a/vast_post_processing/data/default_config.yaml b/vast_post_processing/data/default_config.yaml
index 4a8c2b8..18330fa 100644
--- a/vast_post_processing/data/default_config.yaml
+++ b/vast_post_processing/data/default_config.yaml
@@ -30,6 +30,9 @@ create_moc: True
 # Flag to compress data following pipeline, by default True. 
 compress: True
 
+# Compression quantisation level to use, by default 1024. 
+compress_quant: 1024
+
 # Suffix to use for processed data directories
 # By default "PROCESSED" which results in e.g. `STOKESI_IMAGES_PROCESSED
 directory_suffix: "PROCESSED"