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from human depletion databases, mask any sequence similar to viral or bacterial #805

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notestaff opened this issue Mar 29, 2018 · 1 comment

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notestaff commented Mar 29, 2018

Reduce the chance of erroneously depleting viral or bacterial sequences that have remote homology to human.

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tomkinsc commented Mar 29, 2018 •

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Brian Bushnell at JGI has a tool for masking by similarity and also low entropy regions, BBMask, could be worth a look:
https://jgi.doe.gov/data-and-tools/bbtools/bb-tools-user-guide/bbmask-guide/
(background thread:)
http://seqanswers.com/forums/showthread.php?t=42552

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