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Partition heritability for UKB data #437

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reshu23 opened this issue Jun 14, 2024 · 0 comments
Open

Partition heritability for UKB data #437

reshu23 opened this issue Jun 14, 2024 · 0 comments

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@reshu23
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reshu23 commented Jun 14, 2024

Dear Team,

I have used following GWAS sumstats for partition heritability calculation in ATAC seq peaks.
https://zenodo.org/records/10515792
Sumstats files for EUR populations:
sumstats_indep107.tgz (NEW)

It includes 31 UKB datasets. ("UKB_460K.repro_NumberChildrenEverBorn_Pooled","UKB_460K.cancer_PROSTATE" ,"PANUKBB.Breast_Cancer_female"and so on)

Do I need to use specific parameters for UKB datasets? I have used following command for all sumstats.

python3_ldsc/./ldsc.py --h2 ${dir_GWAS}/${trait}.sumstats.gz
--ref-ld-chr ${dir_baselineLD}/baselineLD.,NonOverlappingPeaks/Annot_ldscores/${prefix_annot}/${prefix_annot}.
--frqfile-chr Database_unzip/1000G_Phase3_frq/1000G.EUR.QC.
--w-ld-chr Database_unzip/1000G_Phase3_weights_hm3_no_MHC/weights.hm3_noMHC.
--overlap-annot --print-cov --print-coefficients --print-delete-vals
--out ${dir_out}/${trait}_${prefix_annot}_baselineLDv2.2

Thank you.

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