The revolver package implements the statistical model described in
Caravagna et al; PMID:
30171232 to determine
trajectories of repeated evolution from multi-region sequencing data of
human cancers.The package implements functions to process data from
large cohorts, and determine different types of phylogenetic trees from
the input data of each input patients. The package provides also several
functions to plot the data and determine clusters of patients that share
repeated evolutionary trajectories; this provides a method to stratify
cancer patients for the way their tumour evolve, reconciling tumour
heterogeneity both between and within patients.
If you use revolver, please cite:
- G. Caravagna, Y. Giarratano, D. Ramazzoti, I. Tomlinson, T.A. Graham, G. Sanguinetti, A. Sottoriva. Detecting repeated cancer evolution from multi-region tumor sequencing data. Nature Methods 15, 707–714 (2018).
You can install the released version of revolver from
GitHub with:
# install.packages("devtools")
devtools::install_github("caravagnalab.github.io/revolver")Cancer Data Science (CDS) Laboratory. University of Trieste, Italy.
