From 18b679f86188a858f4ffd33bc3937fe952e176b9 Mon Sep 17 00:00:00 2001
From: GitHub Actions <actions@github.com>
Date: Mon, 16 Sep 2024 17:04:56 +0000
Subject: [PATCH] site deploy

Auto-generated via {sandpaper}
Source  : f5752d96f8f422a61126c31d9d70766ae62e0478
Branch  : md-outputs
Author  : GitHub Actions <actions@github.com>
Time    : 2024-09-16 17:03:53 +0000
Message : markdown source builds

Auto-generated via {sandpaper}
Source  : d77ef7d1e98b1ad0e070f9eef4bc20f9efbb386b
Branch  : main
Author  : Andrew Ghazi <6763470+andrewGhazi@users.noreply.github.com>
Time    : 2024-09-16 16:58:46 +0000
Message : Merge pull request #37 from ccb-hms/learner_profiles

Learner profiles
---
 404.html                                      |   4 +-
 CODE_OF_CONDUCT.html                          |   2 +-
 LICENSE.html                                  |   2 +-
 aio.html                                      | 154 ++++++++++--------
 cell_type_annotation.html                     |   2 +-
 eda_qc.html                                   |  14 +-
 fig/intro-sce-rendered-unnamed-chunk-14-1.png | Bin 0 -> 59865 bytes
 hca.html                                      |   2 +-
 images.html                                   |   6 +-
 index.html                                    |   4 +-
 instructor-notes.html                         |  17 +-
 instructor/404.html                           |   4 +-
 instructor/CODE_OF_CONDUCT.html               |   2 +-
 instructor/LICENSE.html                       |   2 +-
 instructor/aio.html                           | 154 ++++++++++--------
 instructor/cell_type_annotation.html          |   2 +-
 instructor/eda_qc.html                        |  14 +-
 instructor/hca.html                           |   2 +-
 instructor/images.html                        |   6 +-
 instructor/index.html                         |   4 +-
 instructor/instructor-notes.html              |  17 +-
 instructor/intro-sce.html                     | 124 ++++++++------
 instructor/key-points.html                    |   4 +-
 instructor/large_data.html                    |   2 +-
 instructor/multi-sample.html                  |  16 +-
 instructor/profiles.html                      |   4 +-
 instructor/reference.html                     |   2 +-
 intro-sce.html                                | 124 ++++++++------
 key-points.html                               |   4 +-
 large_data.html                               |   2 +-
 md5sum.txt                                    |   4 +-
 multi-sample.html                             |  16 +-
 pkgdown.yml                                   |   2 +-
 profiles.html                                 |   4 +-
 reference.html                                |   2 +-
 35 files changed, 417 insertions(+), 307 deletions(-)
 create mode 100644 fig/intro-sce-rendered-unnamed-chunk-14-1.png

diff --git a/404.html b/404.html
index c296098..841dfa9 100644
--- a/404.html
+++ b/404.html
@@ -376,8 +376,8 @@ <h1>Page not found</h1>
   "url": "https://ccb-hms.github.io/osca-carpentries/404.html",
   "identifier": "https://ccb-hms.github.io/osca-carpentries/404.html",
   "dateCreated": "2024-01-10",
-  "dateModified": "2024-09-13",
-  "datePublished": "2024-09-13"
+  "dateModified": "2024-09-16",
+  "datePublished": "2024-09-16"
 }
 
   </script><script>
diff --git a/CODE_OF_CONDUCT.html b/CODE_OF_CONDUCT.html
index 6bd38cf..fa9b87d 100644
--- a/CODE_OF_CONDUCT.html
+++ b/CODE_OF_CONDUCT.html
@@ -399,7 +399,7 @@ <h1>Contributor Code of Conduct</h1>
   "identifier": "https://ccb-hms.github.io/osca-carpentries/CODE_OF_CONDUCT.html",
   "dateCreated": "2024-01-10",
   "dateModified": "2024-09-06",
-  "datePublished": "2024-09-13"
+  "datePublished": "2024-09-16"
 }
 
   </script><script>
diff --git a/LICENSE.html b/LICENSE.html
index a530640..8ce94fc 100644
--- a/LICENSE.html
+++ b/LICENSE.html
@@ -447,7 +447,7 @@ <h1>Licenses</h1>
   "identifier": "https://ccb-hms.github.io/osca-carpentries/LICENSE.html",
   "dateCreated": "2024-01-10",
   "dateModified": "2024-09-06",
-  "datePublished": "2024-09-13"
+  "datePublished": "2024-09-16"
 }
 
   </script><script>
diff --git a/aio.html b/aio.html
index ad964d1..9fcd092 100644
--- a/aio.html
+++ b/aio.html
@@ -368,7 +368,7 @@ <h2 class="accordion-header" id="flush-headingTwelve">
         
 <section id="aio-intro-sce"><p>Content from <a href="intro-sce.html">Introduction to Bioconductor and the SingleCellExperiment class</a></p>
 <hr>
-<p>Last updated on 2024-09-13 |
+<p>Last updated on 2024-09-16 |
 
         <a href="https://github.com/ccb-hms/osca-carpentries/edit/main/episodes/intro-sce.Rmd" class="external-link">Edit this page <i aria-hidden="true" data-feather="edit"></i></a></p>
 <div class="text-end">
@@ -573,41 +573,28 @@ <h3 class="code-label">OUTPUT<i aria-hidden="true" data-feather="chevron-left"><
 (e.g., numeric matrices, lists, etc.). Here we’ll review the main slots
 of the SingleCellExperiment class as well as their getter/setter
 methods.</p>
-<div id="challenge1" class="callout challenge">
+<div id="discussion1" class="callout discussion">
 <div class="callout-square">
-<i class="callout-icon" data-feather="zap"></i>
+<i class="callout-icon" data-feather="message-circle"></i>
 </div>
 <div class="callout-inner">
 <h3 class="callout-title">Challenge</h3>
 <div class="callout-content">
-<p>Before <code>SingleCellExperiment</code>, coders working with single
-cell data would sometimes keep all of these components in separate
-objects e.g. a matrix of counts, a data.frame of sample metadata, a
-data.frame of gene annotations and so on. What are the main
-disadvantages of this sort of “from scratch” approach?</p>
-</div>
-</div>
-</div>
-<div id="accordionSolution1" class="accordion challenge-accordion accordion-flush">
-<div class="accordion-item">
-<button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution1" aria-expanded="false" aria-controls="collapseSolution1">
-  <h4 class="accordion-header" id="headingSolution1"> Show me the solution </h4>
-</button>
-<div id="collapseSolution1" class="accordion-collapse collapse" data-bs-parent="#accordionSolution1" aria-labelledby="headingSolution1">
-<div class="accordion-body">
-<ol style="list-style-type: decimal">
-<li><p>You have to do tons of book-keeping! If you perform a QC step
-that removes dead cells, now you also have to remember to remove that
-same set of cells from the cell-wise metadata. Dropped un-expressed
-genes? Don’t forget to filter the gene metadata table too.</p></li>
-<li><p>All the downstream steps have to be “from scratch” as well! All
-the data munging, analysis, and visualization code has to be customized
-to the idiosyncrasies of your input. Agh!</p></li>
-</ol>
+<p>Try to get the data for a different sample from
+<code>WTChimeraData</code> (other than the fifth one) ::: solution</p>
+<p>Here we assign the sixth sample to <code>sce6</code>:</p>
+<div class="codewrapper sourceCode" id="cb9">
+<h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
+</h3>
+<pre class="downlit sourceCode r">
+<code class="sourceCode R"><span><span class="va">sce6</span> <span class="op">&lt;-</span> <span class="fu">WTChimeraData</span><span class="op">(</span>samples <span class="op">=</span> <span class="fl">6</span><span class="op">)</span></span>
+<span></span>
+<span><span class="va">sce6</span></span></code></pre>
 </div>
 </div>
 </div>
 </div>
+<p>::::</p>
 </div>
 <div class="section level3">
 <h3 id="assays">
@@ -620,7 +607,7 @@ <h3 id="assays">
 <code>assay</code> function. If one of these matrices is called
 “counts”, we can use the special <code>counts</code> getter (likewise
 for <code>logcounts</code>).</p>
-<div class="codewrapper sourceCode" id="cb9">
+<div class="codewrapper sourceCode" id="cb10">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
 </h3>
 <pre class="downlit sourceCode r">
@@ -631,7 +618,7 @@ <h3 class="code-label">OUTPUT<i aria-hidden="true" data-feather="chevron-left"><
 </h3>
 <pre class="output" tabindex="0"><code>[1] "counts"</code></pre>
 </div>
-<div class="codewrapper sourceCode" id="cb11">
+<div class="codewrapper sourceCode" id="cb12">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
 </h3>
 <pre class="downlit sourceCode r">
@@ -660,7 +647,7 @@ <h3 id="coldata-and-rowdata">
 the rows of your assay, respectively.</p>
 <p>One can interact with them as usual, e.g., by extracting columns or
 adding additional variables as columns.</p>
-<div class="codewrapper sourceCode" id="cb13">
+<div class="codewrapper sourceCode" id="cb14">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
 </h3>
 <pre class="downlit sourceCode r">
@@ -676,7 +663,7 @@ <h3 class="code-label">OUTPUT<i aria-hidden="true" data-feather="chevron-left"><
 cell_9770   cell_9770 AAACCTGAGATGCCTT         5        E8.5
 cell_9771   cell_9771 AAACCTGAGCAGCCTC         5        E8.5</code></pre>
 </div>
-<div class="codewrapper sourceCode" id="cb15">
+<div class="codewrapper sourceCode" id="cb16">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
 </h3>
 <pre class="downlit sourceCode r">
@@ -694,7 +681,7 @@ <h3 class="code-label">OUTPUT<i aria-hidden="true" data-feather="chevron-left"><
 </div>
 <p>You can access columns of the colData with the <code>$</code>
 accessor to quickly add cell-wise metadata to the colData</p>
-<div class="codewrapper sourceCode" id="cb17">
+<div class="codewrapper sourceCode" id="cb18">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
 </h3>
 <pre class="downlit sourceCode r">
@@ -722,7 +709,7 @@ <h3 class="code-label">OUTPUT<i aria-hidden="true" data-feather="chevron-left"><
 cell_9770    1.22757     29309
 cell_9771    1.15439     28795</code></pre>
 </div>
-<div id="challenge2" class="callout challenge">
+<div id="challenge1" class="callout challenge">
 <div class="callout-square">
 <i class="callout-icon" data-feather="zap"></i>
 </div>
@@ -733,16 +720,16 @@ <h3 class="callout-title">Challenge</h3>
 </div>
 </div>
 </div>
-<div id="accordionSolution2" class="accordion challenge-accordion accordion-flush">
+<div id="accordionSolution1" class="accordion challenge-accordion accordion-flush">
 <div class="accordion-item">
-<button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution2" aria-expanded="false" aria-controls="collapseSolution2">
-  <h4 class="accordion-header" id="headingSolution2"> Show me the solution </h4>
+<button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution1" aria-expanded="false" aria-controls="collapseSolution1">
+  <h4 class="accordion-header" id="headingSolution1"> Show me the solution </h4>
 </button>
-<div id="collapseSolution2" class="accordion-collapse collapse" data-bs-parent="#accordionSolution2" aria-labelledby="headingSolution2">
+<div id="collapseSolution1" class="accordion-collapse collapse" data-bs-parent="#accordionSolution1" aria-labelledby="headingSolution1">
 <div class="accordion-body">
 <p>Here we add a column called “conservation” that is just an integer
 sequence from 1 to the number of genes.</p>
-<div class="codewrapper sourceCode" id="cb19">
+<div class="codewrapper sourceCode" id="cb20">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
 </h3>
 <pre class="downlit sourceCode r">
@@ -769,7 +756,7 @@ <h3 id="the-reduceddims">The <code>reducedDims</code>
 <p>One peculiarity of <code>SingleCellExperiment</code> is its ability
 to store reduced dimension matrices within the object. These may include
 PCA, t-SNE, UMAP, etc.</p>
-<div class="codewrapper sourceCode" id="cb20">
+<div class="codewrapper sourceCode" id="cb21">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
 </h3>
 <pre class="downlit sourceCode r">
@@ -791,7 +778,7 @@ <h3 class="code-label">OUTPUT<i aria-hidden="true" data-feather="chevron-left"><
 <em>indirectly</em> from the objects. Note that one could obtain the
 same results (somewhat less efficiently) by extracting the corresponding
 <code>reducedDim</code> matrix and <code>ggplot</code>.</p>
-<div class="codewrapper sourceCode" id="cb22">
+<div class="codewrapper sourceCode" id="cb23">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
 </h3>
 <pre class="downlit sourceCode r">
@@ -799,7 +786,7 @@ <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i
 <span></span>
 <span><span class="fu">plotReducedDim</span><span class="op">(</span><span class="va">sce</span>, <span class="st">"pca.corrected.E8.5"</span>, colour_by <span class="op">=</span> <span class="st">"celltype.mapped"</span><span class="op">)</span></span></code></pre>
 </div>
-<figure><img src="fig/intro-sce-rendered-unnamed-chunk-13-1.png" style="display: block; margin: auto;" class="figure mx-auto d-block"></figure><div id="exercise-1" class="callout challenge">
+<figure><img src="fig/intro-sce-rendered-unnamed-chunk-14-1.png" style="display: block; margin: auto;" class="figure mx-auto d-block"></figure><div id="exercise-1" class="callout challenge">
 <div class="callout-square">
 <i class="callout-icon" data-feather="zap"></i>
 </div>
@@ -826,14 +813,14 @@ <h4 class="accordion-header" id="headingHint1"> Give me a hint </h4>
 </div>
 </div>
 </div>
-<div id="accordionSolution3" class="accordion challenge-accordion accordion-flush">
+<div id="accordionSolution2" class="accordion challenge-accordion accordion-flush">
 <div class="accordion-item">
-<button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution3" aria-expanded="false" aria-controls="collapseSolution3">
-  <h4 class="accordion-header" id="headingSolution3"> Show me the solution </h4>
+<button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution2" aria-expanded="false" aria-controls="collapseSolution2">
+  <h4 class="accordion-header" id="headingSolution2"> Show me the solution </h4>
 </button>
-<div id="collapseSolution3" class="accordion-collapse collapse" data-bs-parent="#accordionSolution3" aria-labelledby="headingSolution3">
+<div id="collapseSolution2" class="accordion-collapse collapse" data-bs-parent="#accordionSolution2" aria-labelledby="headingSolution2">
 <div class="accordion-body">
-<div class="codewrapper sourceCode" id="cb23">
+<div class="codewrapper sourceCode" id="cb24">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
 </h3>
 <pre class="downlit sourceCode r">
@@ -879,14 +866,14 @@ <h3 class="callout-title">Exercise 2</h3>
 </div>
 </div>
 </div>
-<div id="accordionSolution4" class="accordion challenge-accordion accordion-flush">
+<div id="accordionSolution3" class="accordion challenge-accordion accordion-flush">
 <div class="accordion-item">
-<button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution4" aria-expanded="false" aria-controls="collapseSolution4">
-  <h4 class="accordion-header" id="headingSolution4"> Show me the solution </h4>
+<button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution3" aria-expanded="false" aria-controls="collapseSolution3">
+  <h4 class="accordion-header" id="headingSolution3"> Show me the solution </h4>
 </button>
-<div id="collapseSolution4" class="accordion-collapse collapse" data-bs-parent="#accordionSolution4" aria-labelledby="headingSolution4">
+<div id="collapseSolution3" class="accordion-collapse collapse" data-bs-parent="#accordionSolution3" aria-labelledby="headingSolution3">
 <div class="accordion-body">
-<div class="codewrapper sourceCode" id="cb25">
+<div class="codewrapper sourceCode" id="cb26">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
 </h3>
 <pre class="downlit sourceCode r">
@@ -918,6 +905,41 @@ <h3 class="code-label">OUTPUT<i aria-hidden="true" data-feather="chevron-left"><
 </div>
 </div>
 </div>
+<div id="extension-challenge-1" class="callout challenge">
+<div class="callout-square">
+<i class="callout-icon" data-feather="zap"></i>
+</div>
+<div id="extension-challenge-1" class="callout-inner">
+<h3 class="callout-title">Extension Challenge 1</h3>
+<div class="callout-content">
+<p>Before <code>SingleCellExperiment</code>, coders working with single
+cell data would sometimes keep all of these components in separate
+objects e.g. a matrix of counts, a data.frame of sample metadata, a
+data.frame of gene annotations and so on. What are the main
+disadvantages of this sort of “from scratch” approach?</p>
+</div>
+</div>
+</div>
+<div id="accordionSolution4" class="accordion challenge-accordion accordion-flush">
+<div class="accordion-item">
+<button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution4" aria-expanded="false" aria-controls="collapseSolution4">
+  <h4 class="accordion-header" id="headingSolution4"> Show me the solution </h4>
+</button>
+<div id="collapseSolution4" class="accordion-collapse collapse" data-bs-parent="#accordionSolution4" aria-labelledby="headingSolution4">
+<div class="accordion-body">
+<ol style="list-style-type: decimal">
+<li><p>You have to do tons of book-keeping! If you perform a QC step
+that removes dead cells, now you also have to remember to remove that
+same set of cells from the cell-wise metadata. Dropped un-expressed
+genes? Don’t forget to filter the gene metadata table too.</p></li>
+<li><p>All the downstream steps have to be “from scratch” as well! All
+the data munging, analysis, and visualization code has to be customized
+to the idiosyncrasies of your input. Agh!</p></li>
+</ol>
+</div>
+</div>
+</div>
+</div>
 <div id="further-reading" class="callout checklist">
 <div class="callout-square">
 <i class="callout-icon" data-feather="check-square"></i>
@@ -1116,7 +1138,7 @@ <h3 class="callout-title">Challenge</h3>
 <button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution1" aria-expanded="false" aria-controls="collapseSolution1">
   <h4 class="accordion-header" id="headingSolution1"> Show me the solution </h4>
 </button>
-<div id="collapseSolution1" class="accordion-collapse collapse" aria-labelledby="headingSolution1" data-bs-parent="#accordionSolution1">
+<div id="collapseSolution1" class="accordion-collapse collapse" data-bs-parent="#accordionSolution1" aria-labelledby="headingSolution1">
 <div class="accordion-body">
 <div class="codewrapper sourceCode" id="cb4">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
@@ -1196,7 +1218,7 @@ <h3 class="code-label">OUTPUT<i aria-hidden="true" data-feather="chevron-left"><
 <button class="accordion-button spoiler-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSpoiler1" aria-expanded="false" aria-controls="collapseSpoiler1">
   <h3 class="accordion-header" id="headingSpoiler1">  <div class="note-square"><i aria-hidden="true" class="callout-icon" data-feather="eye"></i></div> Setting the Random Seed </h3>
 </button>
-<div id="collapseSpoiler1" class="accordion-collapse collapse" aria-labelledby="headingSpoiler1" data-bs-parent="#accordionSpoiler1">
+<div id="collapseSpoiler1" class="accordion-collapse collapse" data-bs-parent="#accordionSpoiler1" aria-labelledby="headingSpoiler1">
 <div class="accordion-body">
 <p>Whenever your code involves the generation of random numbers, it’s a
 good practice to set the random seed in R with
@@ -1429,7 +1451,7 @@ <h3 class="callout-title">Challenge</h3>
 <button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution2" aria-expanded="false" aria-controls="collapseSolution2">
   <h4 class="accordion-header" id="headingSolution2"> Show me the solution </h4>
 </button>
-<div id="collapseSolution2" class="accordion-collapse collapse" aria-labelledby="headingSolution2" data-bs-parent="#accordionSolution2">
+<div id="collapseSolution2" class="accordion-collapse collapse" data-bs-parent="#accordionSolution2" aria-labelledby="headingSolution2">
 <div class="accordion-body">
 <div class="codewrapper sourceCode" id="cb25">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
@@ -1705,7 +1727,7 @@ <h3 class="callout-title">Challenge</h3>
 <button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution3" aria-expanded="false" aria-controls="collapseSolution3">
   <h4 class="accordion-header" id="headingSolution3"> Show me the solution </h4>
 </button>
-<div id="collapseSolution3" class="accordion-collapse collapse" aria-labelledby="headingSolution3" data-bs-parent="#accordionSolution3">
+<div id="collapseSolution3" class="accordion-collapse collapse" data-bs-parent="#accordionSolution3" aria-labelledby="headingSolution3">
 <div class="accordion-body">
 <p>Spike-ins are deliberately-introduced exogeneous RNA from an exotic
 or synthetic source at a known concentration. This provides a known
@@ -2000,7 +2022,7 @@ <h3 class="callout-title">Challenge</h3>
 <button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution4" aria-expanded="false" aria-controls="collapseSolution4">
   <h4 class="accordion-header" id="headingSolution4"> Show me the solution </h4>
 </button>
-<div id="collapseSolution4" class="accordion-collapse collapse" aria-labelledby="headingSolution4" data-bs-parent="#accordionSolution4">
+<div id="collapseSolution4" class="accordion-collapse collapse" data-bs-parent="#accordionSolution4" aria-labelledby="headingSolution4">
 <div class="accordion-body">
 <p>Mathematically, this would require the data to fall on a
 two-dimensional plane (for linear methods like PCA) or a smooth 2D
@@ -2170,7 +2192,7 @@ <h3 class="callout-title">Exercise 2: Dimensionality Reduction</h3>
 <button class="accordion-button hint-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseHint1" aria-expanded="false" aria-controls="collapseHint1">
   <h4 class="accordion-header" id="headingHint1"> Give me a hint </h4>
 </button>
-<div id="collapseHint1" class="accordion-collapse collapse" aria-labelledby="headingHint1" data-bs-parent="#accordionHint1">
+<div id="collapseHint1" class="accordion-collapse collapse" data-bs-parent="#accordionHint1" aria-labelledby="headingHint1">
 <div class="accordion-body">
 <p>First subset the object to include only highly variable genes
 (<code>sce2 &lt;- sce[hvg.sce.var,]</code>) and then apply the
@@ -3686,7 +3708,7 @@ <h3 class="callout-title">Challenge</h3>
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   <h4 class="accordion-header" id="headingSolution1"> Show me the solution </h4>
 </button>
-<div id="collapseSolution1" class="accordion-collapse collapse" aria-labelledby="headingSolution1" data-bs-parent="#accordionSolution1">
+<div id="collapseSolution1" class="accordion-collapse collapse" data-bs-parent="#accordionSolution1" aria-labelledby="headingSolution1">
 <div class="accordion-body">
 <p>Samples 5 and 6 were from the same “pool” of cells. Looking at the
 documentation for the dataset under <code>?WTChimeraData</code> we see
@@ -3752,7 +3774,7 @@ <h3 class="callout-title">Challenge</h3>
 <button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution2" aria-expanded="false" aria-controls="collapseSolution2">
   <h4 class="accordion-header" id="headingSolution2"> Show me the solution </h4>
 </button>
-<div id="collapseSolution2" class="accordion-collapse collapse" aria-labelledby="headingSolution2" data-bs-parent="#accordionSolution2">
+<div id="collapseSolution2" class="accordion-collapse collapse" data-bs-parent="#accordionSolution2" aria-labelledby="headingSolution2">
 <div class="accordion-body">
 <p>It’s important to have multiple samples within each experimental
 group because it helps the batch effect correction algorithm distinguish
@@ -4206,7 +4228,7 @@ <h3 class="callout-title">Challenge</h3>
 <button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution3" aria-expanded="false" aria-controls="collapseSolution3">
   <h4 class="accordion-header" id="headingSolution3"> Show me the solution </h4>
 </button>
-<div id="collapseSolution3" class="accordion-collapse collapse" aria-labelledby="headingSolution3" data-bs-parent="#accordionSolution3">
+<div id="collapseSolution3" class="accordion-collapse collapse" data-bs-parent="#accordionSolution3" aria-labelledby="headingSolution3">
 <div class="accordion-body">
 <p>“logFC” stands for log fold-change. Rather than reporting e.g. a
 5-fold increase, it’s better to report a logFC of log(5) = 1.61.
@@ -4532,7 +4554,7 @@ <h3 class="callout-title">Exercise 1: Replicates</h3>
 <button class="accordion-button hint-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseHint1" aria-expanded="false" aria-controls="collapseHint1">
   <h4 class="accordion-header" id="headingHint1"> Give me a hint </h4>
 </button>
-<div id="collapseHint1" class="accordion-collapse collapse" aria-labelledby="headingHint1" data-bs-parent="#accordionHint1">
+<div id="collapseHint1" class="accordion-collapse collapse" data-bs-parent="#accordionHint1" aria-labelledby="headingHint1">
 <div class="accordion-body">
 <p>Remember, you can subset SingleCellExperiments with logical indices,
 just like a matrix. You can also access their column data with the
@@ -4546,7 +4568,7 @@ <h4 class="accordion-header" id="headingHint1"> Give me a hint </h4>
 <button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution4" aria-expanded="false" aria-controls="collapseSolution4">
   <h4 class="accordion-header" id="headingSolution4"> Show me the solution </h4>
 </button>
-<div id="collapseSolution4" class="accordion-collapse collapse" aria-labelledby="headingSolution4" data-bs-parent="#accordionSolution4">
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 <div class="accordion-body">
 <div class="codewrapper sourceCode" id="cb52">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
@@ -4583,7 +4605,7 @@ <h3 class="callout-title">Exercise 2:</h3>
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   <h4 class="accordion-header" id="headingHint2"> Give me a hint </h4>
 </button>
-<div id="collapseHint2" class="accordion-collapse collapse" aria-labelledby="headingHint2" data-bs-parent="#accordionHint2">
+<div id="collapseHint2" class="accordion-collapse collapse" data-bs-parent="#accordionHint2" aria-labelledby="headingHint2">
 <div class="accordion-body">
 <p>You can just hand <code>pheatmap()</code> a matrix as its only
 argument. It has a million options, but the defaults are usually pretty
@@ -4597,7 +4619,7 @@ <h4 class="accordion-header" id="headingHint2"> Give me a hint </h4>
 <button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution5" aria-expanded="false" aria-controls="collapseSolution5">
   <h4 class="accordion-header" id="headingSolution5"> Show me the solution </h4>
 </button>
-<div id="collapseSolution5" class="accordion-collapse collapse" aria-labelledby="headingSolution5" data-bs-parent="#accordionSolution5">
+<div id="collapseSolution5" class="accordion-collapse collapse" data-bs-parent="#accordionSolution5" aria-labelledby="headingSolution5">
 <div class="accordion-body">
 <div class="codewrapper sourceCode" id="cb53">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
@@ -6603,8 +6625,8 @@ <h3 class="callout-title">Key Points</h3>
   "url": "https://ccb-hms.github.io/osca-carpentries/aio.html",
   "identifier": "https://ccb-hms.github.io/osca-carpentries/aio.html",
   "dateCreated": "2024-01-10",
-  "dateModified": "2024-09-13",
-  "datePublished": "2024-09-13"
+  "dateModified": "2024-09-16",
+  "datePublished": "2024-09-16"
 }
 
   </script><script>
diff --git a/cell_type_annotation.html b/cell_type_annotation.html
index eb3c976..0607c57 100644
--- a/cell_type_annotation.html
+++ b/cell_type_annotation.html
@@ -1575,7 +1575,7 @@ <h3 class="callout-title">Key Points</h3>
   "identifier": "https://ccb-hms.github.io/osca-carpentries/cell_type_annotation.html",
   "dateCreated": "2024-01-10",
   "dateModified": "2024-09-08",
-  "datePublished": "2024-09-13"
+  "datePublished": "2024-09-16"
 }
 
   </script><script>
diff --git a/eda_qc.html b/eda_qc.html
index 7259d8f..2a67c2e 100644
--- a/eda_qc.html
+++ b/eda_qc.html
@@ -486,7 +486,7 @@ <h3 class="callout-title">Challenge</h3>
 <button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution1" aria-expanded="false" aria-controls="collapseSolution1">
   <h4 class="accordion-header" id="headingSolution1"> Show me the solution </h4>
 </button>
-<div id="collapseSolution1" class="accordion-collapse collapse" aria-labelledby="headingSolution1" data-bs-parent="#accordionSolution1">
+<div id="collapseSolution1" class="accordion-collapse collapse" data-bs-parent="#accordionSolution1" aria-labelledby="headingSolution1">
 <div class="accordion-body">
 <div class="codewrapper sourceCode" id="cb4">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
@@ -565,7 +565,7 @@ <h3 class="code-label">OUTPUT<i aria-hidden="true" data-feather="chevron-left"><
 <button class="accordion-button spoiler-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSpoiler1" aria-expanded="false" aria-controls="collapseSpoiler1">
   <h3 class="accordion-header" id="headingSpoiler1">  <div class="note-square"><i aria-hidden="true" class="callout-icon" data-feather="eye"></i></div> Setting the Random Seed </h3>
 </button>
-<div id="collapseSpoiler1" class="accordion-collapse collapse" aria-labelledby="headingSpoiler1" data-bs-parent="#accordionSpoiler1">
+<div id="collapseSpoiler1" class="accordion-collapse collapse" data-bs-parent="#accordionSpoiler1" aria-labelledby="headingSpoiler1">
 <div class="accordion-body">
 <p>Whenever your code involves the generation of random numbers, it’s a
 good practice to set the random seed in R with
@@ -791,7 +791,7 @@ <h3 class="callout-title">Challenge</h3>
 <button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution2" aria-expanded="false" aria-controls="collapseSolution2">
   <h4 class="accordion-header" id="headingSolution2"> Show me the solution </h4>
 </button>
-<div id="collapseSolution2" class="accordion-collapse collapse" aria-labelledby="headingSolution2" data-bs-parent="#accordionSolution2">
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 <div class="accordion-body">
 <div class="codewrapper sourceCode" id="cb25">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
@@ -1063,7 +1063,7 @@ <h3 class="callout-title">Challenge</h3>
 <button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution3" aria-expanded="false" aria-controls="collapseSolution3">
   <h4 class="accordion-header" id="headingSolution3"> Show me the solution </h4>
 </button>
-<div id="collapseSolution3" class="accordion-collapse collapse" aria-labelledby="headingSolution3" data-bs-parent="#accordionSolution3">
+<div id="collapseSolution3" class="accordion-collapse collapse" data-bs-parent="#accordionSolution3" aria-labelledby="headingSolution3">
 <div class="accordion-body">
 <p>Spike-ins are deliberately-introduced exogeneous RNA from an exotic
 or synthetic source at a known concentration. This provides a known
@@ -1349,7 +1349,7 @@ <h3 class="callout-title">Challenge</h3>
 <button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution4" aria-expanded="false" aria-controls="collapseSolution4">
   <h4 class="accordion-header" id="headingSolution4"> Show me the solution </h4>
 </button>
-<div id="collapseSolution4" class="accordion-collapse collapse" aria-labelledby="headingSolution4" data-bs-parent="#accordionSolution4">
+<div id="collapseSolution4" class="accordion-collapse collapse" data-bs-parent="#accordionSolution4" aria-labelledby="headingSolution4">
 <div class="accordion-body">
 <p>Mathematically, this would require the data to fall on a
 two-dimensional plane (for linear methods like PCA) or a smooth 2D
@@ -1512,7 +1512,7 @@ <h3 class="callout-title">Exercise 2: Dimensionality Reduction</h3>
 <button class="accordion-button hint-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseHint1" aria-expanded="false" aria-controls="collapseHint1">
   <h4 class="accordion-header" id="headingHint1"> Give me a hint </h4>
 </button>
-<div id="collapseHint1" class="accordion-collapse collapse" aria-labelledby="headingHint1" data-bs-parent="#accordionHint1">
+<div id="collapseHint1" class="accordion-collapse collapse" data-bs-parent="#accordionHint1" aria-labelledby="headingHint1">
 <div class="accordion-body">
 <p>First subset the object to include only highly variable genes
 (<code>sce2 &lt;- sce[hvg.sce.var,]</code>) and then apply the
@@ -1663,7 +1663,7 @@ <h3 class="callout-title">Further Reading</h3>
   "identifier": "https://ccb-hms.github.io/osca-carpentries/eda_qc.html",
   "dateCreated": "2024-01-10",
   "dateModified": "2024-09-06",
-  "datePublished": "2024-09-13"
+  "datePublished": "2024-09-16"
 }
 
   </script><script>
diff --git a/fig/intro-sce-rendered-unnamed-chunk-14-1.png b/fig/intro-sce-rendered-unnamed-chunk-14-1.png
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diff --git a/hca.html b/hca.html
index d3f70f9..1de56d4 100644
--- a/hca.html
+++ b/hca.html
@@ -991,7 +991,7 @@ <h3 class="callout-title">Key Points</h3>
   "identifier": "https://ccb-hms.github.io/osca-carpentries/hca.html",
   "dateCreated": "2024-01-10",
   "dateModified": "2024-09-09",
-  "datePublished": "2024-09-13"
+  "datePublished": "2024-09-16"
 }
 
   </script><script>
diff --git a/images.html b/images.html
index 699289a..44a3001 100644
--- a/images.html
+++ b/images.html
@@ -371,7 +371,7 @@ <h2 class="accordion-header" id="flush-headingTwelve">
 <h3 id="intro-sce-figure-1">Figure 1</h3>
 <figure><img src="http://bioconductor.org/books/release/OSCA.intro/images/SingleCellExperiment.png" style="display: block; margin: auto;" class="figure mx-auto d-block"></figure><hr>
 <h3 id="intro-sce-figure-2">Figure 2</h3>
-<figure><img src="fig/intro-sce-rendered-unnamed-chunk-13-1.png" style="display: block; margin: auto;" class="figure mx-auto d-block"></figure><hr></section><section id="eda_qc"><h2 class="section-heading"><a href="eda_qc.html">Exploratory data analysis and quality control</a></h2>
+<figure><img src="fig/intro-sce-rendered-unnamed-chunk-14-1.png" style="display: block; margin: auto;" class="figure mx-auto d-block"></figure><hr></section><section id="eda_qc"><h2 class="section-heading"><a href="eda_qc.html">Exploratory data analysis and quality control</a></h2>
 <hr class="half-width">
 <h3 id="eda_qc-figure-1">Figure 1</h3>
 <figure><img src="fig/eda_qc-rendered-unnamed-chunk-2-1.png" style="display: block; margin: auto;" class="figure mx-auto d-block"></figure><hr>
@@ -492,8 +492,8 @@ <h3 id="hca-figure-1">Figure 1</h3>
   "url": "https://ccb-hms.github.io/osca-carpentries/images.html",
   "identifier": "https://ccb-hms.github.io/osca-carpentries/images.html",
   "dateCreated": "2024-01-10",
-  "dateModified": "2024-09-13",
-  "datePublished": "2024-09-13"
+  "dateModified": "2024-09-16",
+  "datePublished": "2024-09-16"
 }
 
   </script><script>
diff --git a/index.html b/index.html
index d7bb6ea..d1c5a47 100644
--- a/index.html
+++ b/index.html
@@ -608,8 +608,8 @@ <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i
   "url": "https://ccb-hms.github.io/osca-carpentries/index.html",
   "identifier": "https://ccb-hms.github.io/osca-carpentries/index.html",
   "dateCreated": "2024-01-10",
-  "dateModified": "2024-09-13",
-  "datePublished": "2024-09-13"
+  "dateModified": "2024-09-16",
+  "datePublished": "2024-09-16"
 }
 
   </script><script>
diff --git a/instructor-notes.html b/instructor-notes.html
index 882c87f..63a6209 100644
--- a/instructor-notes.html
+++ b/instructor-notes.html
@@ -367,7 +367,18 @@ <h2 class="accordion-header" id="flush-headingTwelve">
         <h1>Instructor Notes</h1>
         
 
-<p>This is a placeholder file. Please add content here.</p>
+<p>This workshop is based on the <a href="https://github.com/Bioconductor/ISMB.OSCA" class="external-link">OSCA tutorial</a> that
+Davide Risso, Dario Righelli, Marcel Ramos, and myself gave at the ISMB
+conference last year. The tutorial is a light version of the <a href="https://bioconductor.org/books/release/OSCA/" class="external-link">OSCA book</a> that
+concentrates on essential aspects for getting started with the book
+(“The OSCA book in a day”). The tutorial is in large parts a faithful
+copy of the OSCA book, but also adds contents that are not (yet) covered
+in the OSCA book such as interoperability with other popular single-cell
+analysis ecosystems and accessing data from the Human Cell Atlas.</p>
+<p>The learner profiles page covers the pre-requisites including the
+basics of statistics, R, and molecular biology. Point this out to
+students in order to help direct those missing large pieces of the
+foundation toward where they need to go.</p>
 <!--
 Place links that you need to refer to multiple times across pages here. Delete
 any links that you are not going to use.
@@ -422,8 +433,8 @@ <h1>Instructor Notes</h1>
   "url": "https://ccb-hms.github.io/osca-carpentries/instructor-notes.html",
   "identifier": "https://ccb-hms.github.io/osca-carpentries/instructor-notes.html",
   "dateCreated": "2024-01-10",
-  "dateModified": "2024-09-13",
-  "datePublished": "2024-09-13"
+  "dateModified": "2024-09-16",
+  "datePublished": "2024-09-16"
 }
 
   </script><script>
diff --git a/instructor/404.html b/instructor/404.html
index e8dc142..0e391f9 100644
--- a/instructor/404.html
+++ b/instructor/404.html
@@ -376,8 +376,8 @@ <h1>Page not found</h1>
   "url": "https://ccb-hms.github.io/osca-carpentries/instructor/404.html",
   "identifier": "https://ccb-hms.github.io/osca-carpentries/instructor/404.html",
   "dateCreated": "2024-01-10",
-  "dateModified": "2024-09-13",
-  "datePublished": "2024-09-13"
+  "dateModified": "2024-09-16",
+  "datePublished": "2024-09-16"
 }
 
   </script><script>
diff --git a/instructor/CODE_OF_CONDUCT.html b/instructor/CODE_OF_CONDUCT.html
index 599a636..0b0aa38 100644
--- a/instructor/CODE_OF_CONDUCT.html
+++ b/instructor/CODE_OF_CONDUCT.html
@@ -401,7 +401,7 @@ <h1>Contributor Code of Conduct</h1>
   "identifier": "https://ccb-hms.github.io/osca-carpentries/instructor/CODE_OF_CONDUCT.html",
   "dateCreated": "2024-01-10",
   "dateModified": "2024-09-06",
-  "datePublished": "2024-09-13"
+  "datePublished": "2024-09-16"
 }
 
   </script><script>
diff --git a/instructor/LICENSE.html b/instructor/LICENSE.html
index 0fa5228..9071b06 100644
--- a/instructor/LICENSE.html
+++ b/instructor/LICENSE.html
@@ -449,7 +449,7 @@ <h1>Licenses</h1>
   "identifier": "https://ccb-hms.github.io/osca-carpentries/instructor/LICENSE.html",
   "dateCreated": "2024-01-10",
   "dateModified": "2024-09-06",
-  "datePublished": "2024-09-13"
+  "datePublished": "2024-09-16"
 }
 
   </script><script>
diff --git a/instructor/aio.html b/instructor/aio.html
index 8f77246..6a8e825 100644
--- a/instructor/aio.html
+++ b/instructor/aio.html
@@ -370,7 +370,7 @@ <h2 class="accordion-header" id="flush-headingTwelve">
         
 <section id="aio-intro-sce"><p>Content from <a href="intro-sce.html">Introduction to Bioconductor and the SingleCellExperiment class</a></p>
 <hr>
-<p>Last updated on 2024-09-13 |
+<p>Last updated on 2024-09-16 |
 
         <a href="https://github.com/ccb-hms/osca-carpentries/edit/main/episodes/intro-sce.Rmd" class="external-link">Edit this page <i aria-hidden="true" data-feather="edit"></i></a></p>
 <p>Estimated time: <i aria-hidden="true" data-feather="clock"></i> 30 minutes</p>
@@ -576,41 +576,28 @@ <h3 class="code-label">OUTPUT<i aria-hidden="true" data-feather="chevron-left"><
 (e.g., numeric matrices, lists, etc.). Here we’ll review the main slots
 of the SingleCellExperiment class as well as their getter/setter
 methods.</p>
-<div id="challenge1" class="callout challenge">
+<div id="discussion1" class="callout discussion">
 <div class="callout-square">
-<i class="callout-icon" data-feather="zap"></i>
+<i class="callout-icon" data-feather="message-circle"></i>
 </div>
 <div class="callout-inner">
 <h3 class="callout-title">Challenge</h3>
 <div class="callout-content">
-<p>Before <code>SingleCellExperiment</code>, coders working with single
-cell data would sometimes keep all of these components in separate
-objects e.g. a matrix of counts, a data.frame of sample metadata, a
-data.frame of gene annotations and so on. What are the main
-disadvantages of this sort of “from scratch” approach?</p>
-</div>
-</div>
-</div>
-<div id="accordionSolution1" class="accordion challenge-accordion accordion-flush">
-<div class="accordion-item">
-<button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution1" aria-expanded="false" aria-controls="collapseSolution1">
-  <h4 class="accordion-header" id="headingSolution1"> Show me the solution </h4>
-</button>
-<div id="collapseSolution1" class="accordion-collapse collapse" data-bs-parent="#accordionSolution1" aria-labelledby="headingSolution1">
-<div class="accordion-body">
-<ol style="list-style-type: decimal">
-<li><p>You have to do tons of book-keeping! If you perform a QC step
-that removes dead cells, now you also have to remember to remove that
-same set of cells from the cell-wise metadata. Dropped un-expressed
-genes? Don’t forget to filter the gene metadata table too.</p></li>
-<li><p>All the downstream steps have to be “from scratch” as well! All
-the data munging, analysis, and visualization code has to be customized
-to the idiosyncrasies of your input. Agh!</p></li>
-</ol>
+<p>Try to get the data for a different sample from
+<code>WTChimeraData</code> (other than the fifth one) ::: solution</p>
+<p>Here we assign the sixth sample to <code>sce6</code>:</p>
+<div class="codewrapper sourceCode" id="cb9">
+<h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
+</h3>
+<pre class="downlit sourceCode r">
+<code class="sourceCode R"><span><span class="va">sce6</span> <span class="op">&lt;-</span> <span class="fu">WTChimeraData</span><span class="op">(</span>samples <span class="op">=</span> <span class="fl">6</span><span class="op">)</span></span>
+<span></span>
+<span><span class="va">sce6</span></span></code></pre>
 </div>
 </div>
 </div>
 </div>
+<p>::::</p>
 </div>
 <div class="section level3">
 <h3 id="assays">
@@ -623,7 +610,7 @@ <h3 id="assays">
 <code>assay</code> function. If one of these matrices is called
 “counts”, we can use the special <code>counts</code> getter (likewise
 for <code>logcounts</code>).</p>
-<div class="codewrapper sourceCode" id="cb9">
+<div class="codewrapper sourceCode" id="cb10">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
 </h3>
 <pre class="downlit sourceCode r">
@@ -634,7 +621,7 @@ <h3 class="code-label">OUTPUT<i aria-hidden="true" data-feather="chevron-left"><
 </h3>
 <pre class="output" tabindex="0"><code>[1] "counts"</code></pre>
 </div>
-<div class="codewrapper sourceCode" id="cb11">
+<div class="codewrapper sourceCode" id="cb12">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
 </h3>
 <pre class="downlit sourceCode r">
@@ -663,7 +650,7 @@ <h3 id="coldata-and-rowdata">
 the rows of your assay, respectively.</p>
 <p>One can interact with them as usual, e.g., by extracting columns or
 adding additional variables as columns.</p>
-<div class="codewrapper sourceCode" id="cb13">
+<div class="codewrapper sourceCode" id="cb14">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
 </h3>
 <pre class="downlit sourceCode r">
@@ -679,7 +666,7 @@ <h3 class="code-label">OUTPUT<i aria-hidden="true" data-feather="chevron-left"><
 cell_9770   cell_9770 AAACCTGAGATGCCTT         5        E8.5
 cell_9771   cell_9771 AAACCTGAGCAGCCTC         5        E8.5</code></pre>
 </div>
-<div class="codewrapper sourceCode" id="cb15">
+<div class="codewrapper sourceCode" id="cb16">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
 </h3>
 <pre class="downlit sourceCode r">
@@ -697,7 +684,7 @@ <h3 class="code-label">OUTPUT<i aria-hidden="true" data-feather="chevron-left"><
 </div>
 <p>You can access columns of the colData with the <code>$</code>
 accessor to quickly add cell-wise metadata to the colData</p>
-<div class="codewrapper sourceCode" id="cb17">
+<div class="codewrapper sourceCode" id="cb18">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
 </h3>
 <pre class="downlit sourceCode r">
@@ -725,7 +712,7 @@ <h3 class="code-label">OUTPUT<i aria-hidden="true" data-feather="chevron-left"><
 cell_9770    1.22757     29309
 cell_9771    1.15439     28795</code></pre>
 </div>
-<div id="challenge2" class="callout challenge">
+<div id="challenge1" class="callout challenge">
 <div class="callout-square">
 <i class="callout-icon" data-feather="zap"></i>
 </div>
@@ -736,16 +723,16 @@ <h3 class="callout-title">Challenge</h3>
 </div>
 </div>
 </div>
-<div id="accordionSolution2" class="accordion challenge-accordion accordion-flush">
+<div id="accordionSolution1" class="accordion challenge-accordion accordion-flush">
 <div class="accordion-item">
-<button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution2" aria-expanded="false" aria-controls="collapseSolution2">
-  <h4 class="accordion-header" id="headingSolution2"> Show me the solution </h4>
+<button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution1" aria-expanded="false" aria-controls="collapseSolution1">
+  <h4 class="accordion-header" id="headingSolution1"> Show me the solution </h4>
 </button>
-<div id="collapseSolution2" class="accordion-collapse collapse" data-bs-parent="#accordionSolution2" aria-labelledby="headingSolution2">
+<div id="collapseSolution1" class="accordion-collapse collapse" data-bs-parent="#accordionSolution1" aria-labelledby="headingSolution1">
 <div class="accordion-body">
 <p>Here we add a column called “conservation” that is just an integer
 sequence from 1 to the number of genes.</p>
-<div class="codewrapper sourceCode" id="cb19">
+<div class="codewrapper sourceCode" id="cb20">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
 </h3>
 <pre class="downlit sourceCode r">
@@ -772,7 +759,7 @@ <h3 id="the-reduceddims">The <code>reducedDims</code>
 <p>One peculiarity of <code>SingleCellExperiment</code> is its ability
 to store reduced dimension matrices within the object. These may include
 PCA, t-SNE, UMAP, etc.</p>
-<div class="codewrapper sourceCode" id="cb20">
+<div class="codewrapper sourceCode" id="cb21">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
 </h3>
 <pre class="downlit sourceCode r">
@@ -794,7 +781,7 @@ <h3 class="code-label">OUTPUT<i aria-hidden="true" data-feather="chevron-left"><
 <em>indirectly</em> from the objects. Note that one could obtain the
 same results (somewhat less efficiently) by extracting the corresponding
 <code>reducedDim</code> matrix and <code>ggplot</code>.</p>
-<div class="codewrapper sourceCode" id="cb22">
+<div class="codewrapper sourceCode" id="cb23">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
 </h3>
 <pre class="downlit sourceCode r">
@@ -802,7 +789,7 @@ <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i
 <span></span>
 <span><span class="fu">plotReducedDim</span><span class="op">(</span><span class="va">sce</span>, <span class="st">"pca.corrected.E8.5"</span>, colour_by <span class="op">=</span> <span class="st">"celltype.mapped"</span><span class="op">)</span></span></code></pre>
 </div>
-<figure><img src="../fig/intro-sce-rendered-unnamed-chunk-13-1.png" style="display: block; margin: auto;" class="figure mx-auto d-block"></figure><div id="exercise-1" class="callout challenge">
+<figure><img src="../fig/intro-sce-rendered-unnamed-chunk-14-1.png" style="display: block; margin: auto;" class="figure mx-auto d-block"></figure><div id="exercise-1" class="callout challenge">
 <div class="callout-square">
 <i class="callout-icon" data-feather="zap"></i>
 </div>
@@ -829,14 +816,14 @@ <h4 class="accordion-header" id="headingHint1"> Give me a hint </h4>
 </div>
 </div>
 </div>
-<div id="accordionSolution3" class="accordion challenge-accordion accordion-flush">
+<div id="accordionSolution2" class="accordion challenge-accordion accordion-flush">
 <div class="accordion-item">
-<button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution3" aria-expanded="false" aria-controls="collapseSolution3">
-  <h4 class="accordion-header" id="headingSolution3"> Show me the solution </h4>
+<button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution2" aria-expanded="false" aria-controls="collapseSolution2">
+  <h4 class="accordion-header" id="headingSolution2"> Show me the solution </h4>
 </button>
-<div id="collapseSolution3" class="accordion-collapse collapse" data-bs-parent="#accordionSolution3" aria-labelledby="headingSolution3">
+<div id="collapseSolution2" class="accordion-collapse collapse" data-bs-parent="#accordionSolution2" aria-labelledby="headingSolution2">
 <div class="accordion-body">
-<div class="codewrapper sourceCode" id="cb23">
+<div class="codewrapper sourceCode" id="cb24">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
 </h3>
 <pre class="downlit sourceCode r">
@@ -882,14 +869,14 @@ <h3 class="callout-title">Exercise 2</h3>
 </div>
 </div>
 </div>
-<div id="accordionSolution4" class="accordion challenge-accordion accordion-flush">
+<div id="accordionSolution3" class="accordion challenge-accordion accordion-flush">
 <div class="accordion-item">
-<button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution4" aria-expanded="false" aria-controls="collapseSolution4">
-  <h4 class="accordion-header" id="headingSolution4"> Show me the solution </h4>
+<button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution3" aria-expanded="false" aria-controls="collapseSolution3">
+  <h4 class="accordion-header" id="headingSolution3"> Show me the solution </h4>
 </button>
-<div id="collapseSolution4" class="accordion-collapse collapse" data-bs-parent="#accordionSolution4" aria-labelledby="headingSolution4">
+<div id="collapseSolution3" class="accordion-collapse collapse" data-bs-parent="#accordionSolution3" aria-labelledby="headingSolution3">
 <div class="accordion-body">
-<div class="codewrapper sourceCode" id="cb25">
+<div class="codewrapper sourceCode" id="cb26">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
 </h3>
 <pre class="downlit sourceCode r">
@@ -921,6 +908,41 @@ <h3 class="code-label">OUTPUT<i aria-hidden="true" data-feather="chevron-left"><
 </div>
 </div>
 </div>
+<div id="extension-challenge-1" class="callout challenge">
+<div class="callout-square">
+<i class="callout-icon" data-feather="zap"></i>
+</div>
+<div id="extension-challenge-1" class="callout-inner">
+<h3 class="callout-title">Extension Challenge 1</h3>
+<div class="callout-content">
+<p>Before <code>SingleCellExperiment</code>, coders working with single
+cell data would sometimes keep all of these components in separate
+objects e.g. a matrix of counts, a data.frame of sample metadata, a
+data.frame of gene annotations and so on. What are the main
+disadvantages of this sort of “from scratch” approach?</p>
+</div>
+</div>
+</div>
+<div id="accordionSolution4" class="accordion challenge-accordion accordion-flush">
+<div class="accordion-item">
+<button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution4" aria-expanded="false" aria-controls="collapseSolution4">
+  <h4 class="accordion-header" id="headingSolution4"> Show me the solution </h4>
+</button>
+<div id="collapseSolution4" class="accordion-collapse collapse" data-bs-parent="#accordionSolution4" aria-labelledby="headingSolution4">
+<div class="accordion-body">
+<ol style="list-style-type: decimal">
+<li><p>You have to do tons of book-keeping! If you perform a QC step
+that removes dead cells, now you also have to remember to remove that
+same set of cells from the cell-wise metadata. Dropped un-expressed
+genes? Don’t forget to filter the gene metadata table too.</p></li>
+<li><p>All the downstream steps have to be “from scratch” as well! All
+the data munging, analysis, and visualization code has to be customized
+to the idiosyncrasies of your input. Agh!</p></li>
+</ol>
+</div>
+</div>
+</div>
+</div>
 <div id="further-reading" class="callout checklist">
 <div class="callout-square">
 <i class="callout-icon" data-feather="check-square"></i>
@@ -1120,7 +1142,7 @@ <h3 class="callout-title">Challenge</h3>
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   <h4 class="accordion-header" id="headingSolution1"> Show me the solution </h4>
 </button>
-<div id="collapseSolution1" class="accordion-collapse collapse" aria-labelledby="headingSolution1" data-bs-parent="#accordionSolution1">
+<div id="collapseSolution1" class="accordion-collapse collapse" data-bs-parent="#accordionSolution1" aria-labelledby="headingSolution1">
 <div class="accordion-body">
 <div class="codewrapper sourceCode" id="cb4">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
@@ -1200,7 +1222,7 @@ <h3 class="code-label">OUTPUT<i aria-hidden="true" data-feather="chevron-left"><
 <button class="accordion-button spoiler-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSpoiler1" aria-expanded="false" aria-controls="collapseSpoiler1">
   <h3 class="accordion-header" id="headingSpoiler1">  <div class="note-square"><i aria-hidden="true" class="callout-icon" data-feather="eye"></i></div> Setting the Random Seed </h3>
 </button>
-<div id="collapseSpoiler1" class="accordion-collapse collapse" aria-labelledby="headingSpoiler1" data-bs-parent="#accordionSpoiler1">
+<div id="collapseSpoiler1" class="accordion-collapse collapse" data-bs-parent="#accordionSpoiler1" aria-labelledby="headingSpoiler1">
 <div class="accordion-body">
 <p>Whenever your code involves the generation of random numbers, it’s a
 good practice to set the random seed in R with
@@ -1433,7 +1455,7 @@ <h3 class="callout-title">Challenge</h3>
 <button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution2" aria-expanded="false" aria-controls="collapseSolution2">
   <h4 class="accordion-header" id="headingSolution2"> Show me the solution </h4>
 </button>
-<div id="collapseSolution2" class="accordion-collapse collapse" aria-labelledby="headingSolution2" data-bs-parent="#accordionSolution2">
+<div id="collapseSolution2" class="accordion-collapse collapse" data-bs-parent="#accordionSolution2" aria-labelledby="headingSolution2">
 <div class="accordion-body">
 <div class="codewrapper sourceCode" id="cb25">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
@@ -1709,7 +1731,7 @@ <h3 class="callout-title">Challenge</h3>
 <button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution3" aria-expanded="false" aria-controls="collapseSolution3">
   <h4 class="accordion-header" id="headingSolution3"> Show me the solution </h4>
 </button>
-<div id="collapseSolution3" class="accordion-collapse collapse" aria-labelledby="headingSolution3" data-bs-parent="#accordionSolution3">
+<div id="collapseSolution3" class="accordion-collapse collapse" data-bs-parent="#accordionSolution3" aria-labelledby="headingSolution3">
 <div class="accordion-body">
 <p>Spike-ins are deliberately-introduced exogeneous RNA from an exotic
 or synthetic source at a known concentration. This provides a known
@@ -2004,7 +2026,7 @@ <h3 class="callout-title">Challenge</h3>
 <button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution4" aria-expanded="false" aria-controls="collapseSolution4">
   <h4 class="accordion-header" id="headingSolution4"> Show me the solution </h4>
 </button>
-<div id="collapseSolution4" class="accordion-collapse collapse" aria-labelledby="headingSolution4" data-bs-parent="#accordionSolution4">
+<div id="collapseSolution4" class="accordion-collapse collapse" data-bs-parent="#accordionSolution4" aria-labelledby="headingSolution4">
 <div class="accordion-body">
 <p>Mathematically, this would require the data to fall on a
 two-dimensional plane (for linear methods like PCA) or a smooth 2D
@@ -2174,7 +2196,7 @@ <h3 class="callout-title">Exercise 2: Dimensionality Reduction</h3>
 <button class="accordion-button hint-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseHint1" aria-expanded="false" aria-controls="collapseHint1">
   <h4 class="accordion-header" id="headingHint1"> Give me a hint </h4>
 </button>
-<div id="collapseHint1" class="accordion-collapse collapse" aria-labelledby="headingHint1" data-bs-parent="#accordionHint1">
+<div id="collapseHint1" class="accordion-collapse collapse" data-bs-parent="#accordionHint1" aria-labelledby="headingHint1">
 <div class="accordion-body">
 <p>First subset the object to include only highly variable genes
 (<code>sce2 &lt;- sce[hvg.sce.var,]</code>) and then apply the
@@ -3692,7 +3714,7 @@ <h3 class="callout-title">Challenge</h3>
 <button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution1" aria-expanded="false" aria-controls="collapseSolution1">
   <h4 class="accordion-header" id="headingSolution1"> Show me the solution </h4>
 </button>
-<div id="collapseSolution1" class="accordion-collapse collapse" aria-labelledby="headingSolution1" data-bs-parent="#accordionSolution1">
+<div id="collapseSolution1" class="accordion-collapse collapse" data-bs-parent="#accordionSolution1" aria-labelledby="headingSolution1">
 <div class="accordion-body">
 <p>Samples 5 and 6 were from the same “pool” of cells. Looking at the
 documentation for the dataset under <code>?WTChimeraData</code> we see
@@ -3758,7 +3780,7 @@ <h3 class="callout-title">Challenge</h3>
 <button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution2" aria-expanded="false" aria-controls="collapseSolution2">
   <h4 class="accordion-header" id="headingSolution2"> Show me the solution </h4>
 </button>
-<div id="collapseSolution2" class="accordion-collapse collapse" aria-labelledby="headingSolution2" data-bs-parent="#accordionSolution2">
+<div id="collapseSolution2" class="accordion-collapse collapse" data-bs-parent="#accordionSolution2" aria-labelledby="headingSolution2">
 <div class="accordion-body">
 <p>It’s important to have multiple samples within each experimental
 group because it helps the batch effect correction algorithm distinguish
@@ -4212,7 +4234,7 @@ <h3 class="callout-title">Challenge</h3>
 <button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution3" aria-expanded="false" aria-controls="collapseSolution3">
   <h4 class="accordion-header" id="headingSolution3"> Show me the solution </h4>
 </button>
-<div id="collapseSolution3" class="accordion-collapse collapse" aria-labelledby="headingSolution3" data-bs-parent="#accordionSolution3">
+<div id="collapseSolution3" class="accordion-collapse collapse" data-bs-parent="#accordionSolution3" aria-labelledby="headingSolution3">
 <div class="accordion-body">
 <p>“logFC” stands for log fold-change. Rather than reporting e.g. a
 5-fold increase, it’s better to report a logFC of log(5) = 1.61.
@@ -4538,7 +4560,7 @@ <h3 class="callout-title">Exercise 1: Replicates</h3>
 <button class="accordion-button hint-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseHint1" aria-expanded="false" aria-controls="collapseHint1">
   <h4 class="accordion-header" id="headingHint1"> Give me a hint </h4>
 </button>
-<div id="collapseHint1" class="accordion-collapse collapse" aria-labelledby="headingHint1" data-bs-parent="#accordionHint1">
+<div id="collapseHint1" class="accordion-collapse collapse" data-bs-parent="#accordionHint1" aria-labelledby="headingHint1">
 <div class="accordion-body">
 <p>Remember, you can subset SingleCellExperiments with logical indices,
 just like a matrix. You can also access their column data with the
@@ -4552,7 +4574,7 @@ <h4 class="accordion-header" id="headingHint1"> Give me a hint </h4>
 <button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution4" aria-expanded="false" aria-controls="collapseSolution4">
   <h4 class="accordion-header" id="headingSolution4"> Show me the solution </h4>
 </button>
-<div id="collapseSolution4" class="accordion-collapse collapse" aria-labelledby="headingSolution4" data-bs-parent="#accordionSolution4">
+<div id="collapseSolution4" class="accordion-collapse collapse" data-bs-parent="#accordionSolution4" aria-labelledby="headingSolution4">
 <div class="accordion-body">
 <div class="codewrapper sourceCode" id="cb52">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
@@ -4589,7 +4611,7 @@ <h3 class="callout-title">Exercise 2:</h3>
 <button class="accordion-button hint-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseHint2" aria-expanded="false" aria-controls="collapseHint2">
   <h4 class="accordion-header" id="headingHint2"> Give me a hint </h4>
 </button>
-<div id="collapseHint2" class="accordion-collapse collapse" aria-labelledby="headingHint2" data-bs-parent="#accordionHint2">
+<div id="collapseHint2" class="accordion-collapse collapse" data-bs-parent="#accordionHint2" aria-labelledby="headingHint2">
 <div class="accordion-body">
 <p>You can just hand <code>pheatmap()</code> a matrix as its only
 argument. It has a million options, but the defaults are usually pretty
@@ -4603,7 +4625,7 @@ <h4 class="accordion-header" id="headingHint2"> Give me a hint </h4>
 <button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution5" aria-expanded="false" aria-controls="collapseSolution5">
   <h4 class="accordion-header" id="headingSolution5"> Show me the solution </h4>
 </button>
-<div id="collapseSolution5" class="accordion-collapse collapse" aria-labelledby="headingSolution5" data-bs-parent="#accordionSolution5">
+<div id="collapseSolution5" class="accordion-collapse collapse" data-bs-parent="#accordionSolution5" aria-labelledby="headingSolution5">
 <div class="accordion-body">
 <div class="codewrapper sourceCode" id="cb53">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
@@ -6611,8 +6633,8 @@ <h3 class="callout-title">Key Points</h3>
   "url": "https://ccb-hms.github.io/osca-carpentries/instructor/aio.html",
   "identifier": "https://ccb-hms.github.io/osca-carpentries/instructor/aio.html",
   "dateCreated": "2024-01-10",
-  "dateModified": "2024-09-13",
-  "datePublished": "2024-09-13"
+  "dateModified": "2024-09-16",
+  "datePublished": "2024-09-16"
 }
 
   </script><script>
diff --git a/instructor/cell_type_annotation.html b/instructor/cell_type_annotation.html
index f115bfa..fb6601e 100644
--- a/instructor/cell_type_annotation.html
+++ b/instructor/cell_type_annotation.html
@@ -1577,7 +1577,7 @@ <h3 class="callout-title">Key Points</h3>
   "identifier": "https://ccb-hms.github.io/osca-carpentries/instructor/cell_type_annotation.html",
   "dateCreated": "2024-01-10",
   "dateModified": "2024-09-08",
-  "datePublished": "2024-09-13"
+  "datePublished": "2024-09-16"
 }
 
   </script><script>
diff --git a/instructor/eda_qc.html b/instructor/eda_qc.html
index 535de86..fb847e9 100644
--- a/instructor/eda_qc.html
+++ b/instructor/eda_qc.html
@@ -488,7 +488,7 @@ <h3 class="callout-title">Challenge</h3>
 <button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution1" aria-expanded="false" aria-controls="collapseSolution1">
   <h4 class="accordion-header" id="headingSolution1"> Show me the solution </h4>
 </button>
-<div id="collapseSolution1" class="accordion-collapse collapse" aria-labelledby="headingSolution1" data-bs-parent="#accordionSolution1">
+<div id="collapseSolution1" class="accordion-collapse collapse" data-bs-parent="#accordionSolution1" aria-labelledby="headingSolution1">
 <div class="accordion-body">
 <div class="codewrapper sourceCode" id="cb4">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
@@ -567,7 +567,7 @@ <h3 class="code-label">OUTPUT<i aria-hidden="true" data-feather="chevron-left"><
 <button class="accordion-button spoiler-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSpoiler1" aria-expanded="false" aria-controls="collapseSpoiler1">
   <h3 class="accordion-header" id="headingSpoiler1">  <div class="note-square"><i aria-hidden="true" class="callout-icon" data-feather="eye"></i></div> Setting the Random Seed </h3>
 </button>
-<div id="collapseSpoiler1" class="accordion-collapse collapse" aria-labelledby="headingSpoiler1" data-bs-parent="#accordionSpoiler1">
+<div id="collapseSpoiler1" class="accordion-collapse collapse" data-bs-parent="#accordionSpoiler1" aria-labelledby="headingSpoiler1">
 <div class="accordion-body">
 <p>Whenever your code involves the generation of random numbers, it’s a
 good practice to set the random seed in R with
@@ -793,7 +793,7 @@ <h3 class="callout-title">Challenge</h3>
 <button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution2" aria-expanded="false" aria-controls="collapseSolution2">
   <h4 class="accordion-header" id="headingSolution2"> Show me the solution </h4>
 </button>
-<div id="collapseSolution2" class="accordion-collapse collapse" aria-labelledby="headingSolution2" data-bs-parent="#accordionSolution2">
+<div id="collapseSolution2" class="accordion-collapse collapse" data-bs-parent="#accordionSolution2" aria-labelledby="headingSolution2">
 <div class="accordion-body">
 <div class="codewrapper sourceCode" id="cb25">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
@@ -1065,7 +1065,7 @@ <h3 class="callout-title">Challenge</h3>
 <button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution3" aria-expanded="false" aria-controls="collapseSolution3">
   <h4 class="accordion-header" id="headingSolution3"> Show me the solution </h4>
 </button>
-<div id="collapseSolution3" class="accordion-collapse collapse" aria-labelledby="headingSolution3" data-bs-parent="#accordionSolution3">
+<div id="collapseSolution3" class="accordion-collapse collapse" data-bs-parent="#accordionSolution3" aria-labelledby="headingSolution3">
 <div class="accordion-body">
 <p>Spike-ins are deliberately-introduced exogeneous RNA from an exotic
 or synthetic source at a known concentration. This provides a known
@@ -1351,7 +1351,7 @@ <h3 class="callout-title">Challenge</h3>
 <button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution4" aria-expanded="false" aria-controls="collapseSolution4">
   <h4 class="accordion-header" id="headingSolution4"> Show me the solution </h4>
 </button>
-<div id="collapseSolution4" class="accordion-collapse collapse" aria-labelledby="headingSolution4" data-bs-parent="#accordionSolution4">
+<div id="collapseSolution4" class="accordion-collapse collapse" data-bs-parent="#accordionSolution4" aria-labelledby="headingSolution4">
 <div class="accordion-body">
 <p>Mathematically, this would require the data to fall on a
 two-dimensional plane (for linear methods like PCA) or a smooth 2D
@@ -1514,7 +1514,7 @@ <h3 class="callout-title">Exercise 2: Dimensionality Reduction</h3>
 <button class="accordion-button hint-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseHint1" aria-expanded="false" aria-controls="collapseHint1">
   <h4 class="accordion-header" id="headingHint1"> Give me a hint </h4>
 </button>
-<div id="collapseHint1" class="accordion-collapse collapse" aria-labelledby="headingHint1" data-bs-parent="#accordionHint1">
+<div id="collapseHint1" class="accordion-collapse collapse" data-bs-parent="#accordionHint1" aria-labelledby="headingHint1">
 <div class="accordion-body">
 <p>First subset the object to include only highly variable genes
 (<code>sce2 &lt;- sce[hvg.sce.var,]</code>) and then apply the
@@ -1665,7 +1665,7 @@ <h3 class="callout-title">Further Reading</h3>
   "identifier": "https://ccb-hms.github.io/osca-carpentries/instructor/eda_qc.html",
   "dateCreated": "2024-01-10",
   "dateModified": "2024-09-06",
-  "datePublished": "2024-09-13"
+  "datePublished": "2024-09-16"
 }
 
   </script><script>
diff --git a/instructor/hca.html b/instructor/hca.html
index 862a812..bff9a2b 100644
--- a/instructor/hca.html
+++ b/instructor/hca.html
@@ -993,7 +993,7 @@ <h3 class="callout-title">Key Points</h3>
   "identifier": "https://ccb-hms.github.io/osca-carpentries/instructor/hca.html",
   "dateCreated": "2024-01-10",
   "dateModified": "2024-09-09",
-  "datePublished": "2024-09-13"
+  "datePublished": "2024-09-16"
 }
 
   </script><script>
diff --git a/instructor/images.html b/instructor/images.html
index 5b37317..722cfd8 100644
--- a/instructor/images.html
+++ b/instructor/images.html
@@ -373,7 +373,7 @@ <h2 class="accordion-header" id="flush-headingTwelve">
 <h3 id="intro-sce-figure-1">Figure 1</h3>
 <figure><img src="http://bioconductor.org/books/release/OSCA.intro/images/SingleCellExperiment.png" style="display: block; margin: auto;" class="figure mx-auto d-block"></figure><hr>
 <h3 id="intro-sce-figure-2">Figure 2</h3>
-<figure><img src="../fig/intro-sce-rendered-unnamed-chunk-13-1.png" style="display: block; margin: auto;" class="figure mx-auto d-block"></figure><hr></section><section id="eda_qc"><h2 class="section-heading"><a href="eda_qc.html">Exploratory data analysis and quality control</a></h2>
+<figure><img src="../fig/intro-sce-rendered-unnamed-chunk-14-1.png" style="display: block; margin: auto;" class="figure mx-auto d-block"></figure><hr></section><section id="eda_qc"><h2 class="section-heading"><a href="eda_qc.html">Exploratory data analysis and quality control</a></h2>
 <hr class="half-width">
 <h3 id="eda_qc-figure-1">Figure 1</h3>
 <figure><img src="../fig/eda_qc-rendered-unnamed-chunk-2-1.png" style="display: block; margin: auto;" class="figure mx-auto d-block"></figure><hr>
@@ -494,8 +494,8 @@ <h3 id="hca-figure-1">Figure 1</h3>
   "url": "https://ccb-hms.github.io/osca-carpentries/instructor/images.html",
   "identifier": "https://ccb-hms.github.io/osca-carpentries/instructor/images.html",
   "dateCreated": "2024-01-10",
-  "dateModified": "2024-09-13",
-  "datePublished": "2024-09-13"
+  "dateModified": "2024-09-16",
+  "datePublished": "2024-09-16"
 }
 
   </script><script>
diff --git a/instructor/index.html b/instructor/index.html
index bc677b4..2553003 100644
--- a/instructor/index.html
+++ b/instructor/index.html
@@ -693,8 +693,8 @@ <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i
   "url": "https://ccb-hms.github.io/osca-carpentries/instructor/index.html",
   "identifier": "https://ccb-hms.github.io/osca-carpentries/instructor/index.html",
   "dateCreated": "2024-01-10",
-  "dateModified": "2024-09-13",
-  "datePublished": "2024-09-13"
+  "dateModified": "2024-09-16",
+  "datePublished": "2024-09-16"
 }
 
   </script><script>
diff --git a/instructor/instructor-notes.html b/instructor/instructor-notes.html
index 50a0686..5d21fa9 100644
--- a/instructor/instructor-notes.html
+++ b/instructor/instructor-notes.html
@@ -369,7 +369,18 @@ <h2 class="accordion-header" id="flush-headingTwelve">
         <h1>Instructor Notes</h1>
         
 
-<p>This is a placeholder file. Please add content here.</p>
+<p>This workshop is based on the <a href="https://github.com/Bioconductor/ISMB.OSCA" class="external-link">OSCA tutorial</a> that
+Davide Risso, Dario Righelli, Marcel Ramos, and myself gave at the ISMB
+conference last year. The tutorial is a light version of the <a href="https://bioconductor.org/books/release/OSCA/" class="external-link">OSCA book</a> that
+concentrates on essential aspects for getting started with the book
+(“The OSCA book in a day”). The tutorial is in large parts a faithful
+copy of the OSCA book, but also adds contents that are not (yet) covered
+in the OSCA book such as interoperability with other popular single-cell
+analysis ecosystems and accessing data from the Human Cell Atlas.</p>
+<p>The learner profiles page covers the pre-requisites including the
+basics of statistics, R, and molecular biology. Point this out to
+students in order to help direct those missing large pieces of the
+foundation toward where they need to go.</p>
 <!--
 Place links that you need to refer to multiple times across pages here. Delete
 any links that you are not going to use.
@@ -430,8 +441,8 @@ <h1>Instructor Notes</h1>
   "url": "https://ccb-hms.github.io/osca-carpentries/instructor/instructor-notes.html",
   "identifier": "https://ccb-hms.github.io/osca-carpentries/instructor/instructor-notes.html",
   "dateCreated": "2024-01-10",
-  "dateModified": "2024-09-13",
-  "datePublished": "2024-09-13"
+  "dateModified": "2024-09-16",
+  "datePublished": "2024-09-16"
 }
 
   </script><script>
diff --git a/instructor/intro-sce.html b/instructor/intro-sce.html
index a40a499..b040452 100644
--- a/instructor/intro-sce.html
+++ b/instructor/intro-sce.html
@@ -327,7 +327,7 @@ <h2 class="accordion-header" id="flush-headingTwelve">
       </div>
       <hr></nav><main id="main-content" class="main-content"><div class="container lesson-content">
         <h1>Introduction to Bioconductor and the SingleCellExperiment class</h1>
-        <p>Last updated on 2024-09-13 |
+        <p>Last updated on 2024-09-16 |
 
         <a href="https://github.com/ccb-hms/osca-carpentries/edit/main/episodes/intro-sce.Rmd" class="external-link">Edit this page <i aria-hidden="true" data-feather="edit"></i></a></p>
 
@@ -526,39 +526,28 @@ <h3 class="code-label">OUTPUT<i aria-hidden="true" data-feather="chevron-left"><
 (e.g., numeric matrices, lists, etc.). Here we’ll review the main slots
 of the SingleCellExperiment class as well as their getter/setter
 methods.</p>
-<div id="challenge1" class="callout challenge">
+<div id="discussion1" class="callout discussion">
 <div class="callout-square">
-<i class="callout-icon" data-feather="zap"></i>
+<i class="callout-icon" data-feather="message-circle"></i>
 </div>
 <div class="callout-inner">
 <h3 class="callout-title">Challenge</h3>
 <div class="callout-content">
-<p>Before <code>SingleCellExperiment</code>, coders working with single
-cell data would sometimes keep all of these components in separate
-objects e.g. a matrix of counts, a data.frame of sample metadata, a
-data.frame of gene annotations and so on. What are the main
-disadvantages of this sort of “from scratch” approach?</p>
+<p>Try to get the data for a different sample from
+<code>WTChimeraData</code> (other than the fifth one) ::: solution</p>
+<p>Here we assign the sixth sample to <code>sce6</code>:</p>
+<div class="codewrapper sourceCode" id="cb9">
+<h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
+</h3>
+<pre class="downlit sourceCode r">
+<code class="sourceCode R"><span><span class="va">sce6</span> <span class="op">&lt;-</span> <span class="fu">WTChimeraData</span><span class="op">(</span>samples <span class="op">=</span> <span class="fl">6</span><span class="op">)</span></span>
+<span></span>
+<span><span class="va">sce6</span></span></code></pre>
 </div>
 </div>
 </div>
-<div id="accordionSolution1" class="accordion challenge-accordion accordion-flush">
-<div class="accordion-item">
-<button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution1" aria-expanded="false" aria-controls="collapseSolution1">
-  <h4 class="accordion-header" id="headingSolution1"> Show me the solution </h4>
-</button>
-<div id="collapseSolution1" class="accordion-collapse collapse" data-bs-parent="#accordionSolution1" aria-labelledby="headingSolution1">
-<div class="accordion-body">
-<ol style="list-style-type: decimal"><li><p>You have to do tons of book-keeping! If you perform a QC step
-that removes dead cells, now you also have to remember to remove that
-same set of cells from the cell-wise metadata. Dropped un-expressed
-genes? Don’t forget to filter the gene metadata table too.</p></li>
-<li><p>All the downstream steps have to be “from scratch” as well! All
-the data munging, analysis, and visualization code has to be customized
-to the idiosyncrasies of your input. Agh!</p></li>
-</ol></div>
-</div>
-</div>
 </div>
+<p>::::</p>
 </div>
 <div class="section level3">
 <h3 id="assays"><code>assays</code><a class="anchor" aria-label="anchor" href="#assays"></a></h3>
@@ -569,7 +558,7 @@ <h3 id="assays"><code>assays</code><a class="anchor" aria-label="anchor" href="#
 <code>assay</code> function. If one of these matrices is called
 “counts”, we can use the special <code>counts</code> getter (likewise
 for <code>logcounts</code>).</p>
-<div class="codewrapper sourceCode" id="cb9">
+<div class="codewrapper sourceCode" id="cb10">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
 </h3>
 <pre class="downlit sourceCode r">
@@ -580,7 +569,7 @@ <h3 class="code-label">OUTPUT<i aria-hidden="true" data-feather="chevron-left"><
 </h3>
 <pre class="output" tabindex="0"><code>[1] "counts"</code></pre>
 </div>
-<div class="codewrapper sourceCode" id="cb11">
+<div class="codewrapper sourceCode" id="cb12">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
 </h3>
 <pre class="downlit sourceCode r">
@@ -608,7 +597,7 @@ <h3 id="coldata-and-rowdata">
 the rows of your assay, respectively.</p>
 <p>One can interact with them as usual, e.g., by extracting columns or
 adding additional variables as columns.</p>
-<div class="codewrapper sourceCode" id="cb13">
+<div class="codewrapper sourceCode" id="cb14">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
 </h3>
 <pre class="downlit sourceCode r">
@@ -624,7 +613,7 @@ <h3 class="code-label">OUTPUT<i aria-hidden="true" data-feather="chevron-left"><
 cell_9770   cell_9770 AAACCTGAGATGCCTT         5        E8.5
 cell_9771   cell_9771 AAACCTGAGCAGCCTC         5        E8.5</code></pre>
 </div>
-<div class="codewrapper sourceCode" id="cb15">
+<div class="codewrapper sourceCode" id="cb16">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
 </h3>
 <pre class="downlit sourceCode r">
@@ -642,7 +631,7 @@ <h3 class="code-label">OUTPUT<i aria-hidden="true" data-feather="chevron-left"><
 </div>
 <p>You can access columns of the colData with the <code>$</code>
 accessor to quickly add cell-wise metadata to the colData</p>
-<div class="codewrapper sourceCode" id="cb17">
+<div class="codewrapper sourceCode" id="cb18">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
 </h3>
 <pre class="downlit sourceCode r">
@@ -670,7 +659,7 @@ <h3 class="code-label">OUTPUT<i aria-hidden="true" data-feather="chevron-left"><
 cell_9770    1.22757     29309
 cell_9771    1.15439     28795</code></pre>
 </div>
-<div id="challenge2" class="callout challenge">
+<div id="challenge1" class="callout challenge">
 <div class="callout-square">
 <i class="callout-icon" data-feather="zap"></i>
 </div>
@@ -681,16 +670,16 @@ <h3 class="callout-title">Challenge</h3>
 </div>
 </div>
 </div>
-<div id="accordionSolution2" class="accordion challenge-accordion accordion-flush">
+<div id="accordionSolution1" class="accordion challenge-accordion accordion-flush">
 <div class="accordion-item">
-<button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution2" aria-expanded="false" aria-controls="collapseSolution2">
-  <h4 class="accordion-header" id="headingSolution2"> Show me the solution </h4>
+<button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution1" aria-expanded="false" aria-controls="collapseSolution1">
+  <h4 class="accordion-header" id="headingSolution1"> Show me the solution </h4>
 </button>
-<div id="collapseSolution2" class="accordion-collapse collapse" data-bs-parent="#accordionSolution2" aria-labelledby="headingSolution2">
+<div id="collapseSolution1" class="accordion-collapse collapse" data-bs-parent="#accordionSolution1" aria-labelledby="headingSolution1">
 <div class="accordion-body">
 <p>Here we add a column called “conservation” that is just an integer
 sequence from 1 to the number of genes.</p>
-<div class="codewrapper sourceCode" id="cb19">
+<div class="codewrapper sourceCode" id="cb20">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
 </h3>
 <pre class="downlit sourceCode r">
@@ -716,7 +705,7 @@ <h3 id="the-reduceddims">The <code>reducedDims</code>
 <p>One peculiarity of <code>SingleCellExperiment</code> is its ability
 to store reduced dimension matrices within the object. These may include
 PCA, t-SNE, UMAP, etc.</p>
-<div class="codewrapper sourceCode" id="cb20">
+<div class="codewrapper sourceCode" id="cb21">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
 </h3>
 <pre class="downlit sourceCode r">
@@ -738,7 +727,7 @@ <h3 class="code-label">OUTPUT<i aria-hidden="true" data-feather="chevron-left"><
 <em>indirectly</em> from the objects. Note that one could obtain the
 same results (somewhat less efficiently) by extracting the corresponding
 <code>reducedDim</code> matrix and <code>ggplot</code>.</p>
-<div class="codewrapper sourceCode" id="cb22">
+<div class="codewrapper sourceCode" id="cb23">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
 </h3>
 <pre class="downlit sourceCode r">
@@ -746,7 +735,7 @@ <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i
 <span></span>
 <span><span class="fu">plotReducedDim</span><span class="op">(</span><span class="va">sce</span>, <span class="st">"pca.corrected.E8.5"</span>, colour_by <span class="op">=</span> <span class="st">"celltype.mapped"</span><span class="op">)</span></span></code></pre>
 </div>
-<figure><img src="../fig/intro-sce-rendered-unnamed-chunk-13-1.png" style="display: block; margin: auto;" class="figure mx-auto d-block"></figure><div id="exercise-1" class="callout challenge">
+<figure><img src="../fig/intro-sce-rendered-unnamed-chunk-14-1.png" style="display: block; margin: auto;" class="figure mx-auto d-block"></figure><div id="exercise-1" class="callout challenge">
 <div class="callout-square">
 <i class="callout-icon" data-feather="zap"></i>
 </div>
@@ -773,14 +762,14 @@ <h4 class="accordion-header" id="headingHint1"> Give me a hint </h4>
 </div>
 </div>
 </div>
-<div id="accordionSolution3" class="accordion challenge-accordion accordion-flush">
+<div id="accordionSolution2" class="accordion challenge-accordion accordion-flush">
 <div class="accordion-item">
-<button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution3" aria-expanded="false" aria-controls="collapseSolution3">
-  <h4 class="accordion-header" id="headingSolution3"> Show me the solution </h4>
+<button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution2" aria-expanded="false" aria-controls="collapseSolution2">
+  <h4 class="accordion-header" id="headingSolution2"> Show me the solution </h4>
 </button>
-<div id="collapseSolution3" class="accordion-collapse collapse" data-bs-parent="#accordionSolution3" aria-labelledby="headingSolution3">
+<div id="collapseSolution2" class="accordion-collapse collapse" data-bs-parent="#accordionSolution2" aria-labelledby="headingSolution2">
 <div class="accordion-body">
-<div class="codewrapper sourceCode" id="cb23">
+<div class="codewrapper sourceCode" id="cb24">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
 </h3>
 <pre class="downlit sourceCode r">
@@ -826,14 +815,14 @@ <h3 class="callout-title">Exercise 2</h3>
 </div>
 </div>
 </div>
-<div id="accordionSolution4" class="accordion challenge-accordion accordion-flush">
+<div id="accordionSolution3" class="accordion challenge-accordion accordion-flush">
 <div class="accordion-item">
-<button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution4" aria-expanded="false" aria-controls="collapseSolution4">
-  <h4 class="accordion-header" id="headingSolution4"> Show me the solution </h4>
+<button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution3" aria-expanded="false" aria-controls="collapseSolution3">
+  <h4 class="accordion-header" id="headingSolution3"> Show me the solution </h4>
 </button>
-<div id="collapseSolution4" class="accordion-collapse collapse" data-bs-parent="#accordionSolution4" aria-labelledby="headingSolution4">
+<div id="collapseSolution3" class="accordion-collapse collapse" data-bs-parent="#accordionSolution3" aria-labelledby="headingSolution3">
 <div class="accordion-body">
-<div class="codewrapper sourceCode" id="cb25">
+<div class="codewrapper sourceCode" id="cb26">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
 </h3>
 <pre class="downlit sourceCode r">
@@ -865,6 +854,39 @@ <h3 class="code-label">OUTPUT<i aria-hidden="true" data-feather="chevron-left"><
 </div>
 </div>
 </div>
+<div id="extension-challenge-1" class="callout challenge">
+<div class="callout-square">
+<i class="callout-icon" data-feather="zap"></i>
+</div>
+<div id="extension-challenge-1" class="callout-inner">
+<h3 class="callout-title">Extension Challenge 1</h3>
+<div class="callout-content">
+<p>Before <code>SingleCellExperiment</code>, coders working with single
+cell data would sometimes keep all of these components in separate
+objects e.g. a matrix of counts, a data.frame of sample metadata, a
+data.frame of gene annotations and so on. What are the main
+disadvantages of this sort of “from scratch” approach?</p>
+</div>
+</div>
+</div>
+<div id="accordionSolution4" class="accordion challenge-accordion accordion-flush">
+<div class="accordion-item">
+<button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution4" aria-expanded="false" aria-controls="collapseSolution4">
+  <h4 class="accordion-header" id="headingSolution4"> Show me the solution </h4>
+</button>
+<div id="collapseSolution4" class="accordion-collapse collapse" data-bs-parent="#accordionSolution4" aria-labelledby="headingSolution4">
+<div class="accordion-body">
+<ol style="list-style-type: decimal"><li><p>You have to do tons of book-keeping! If you perform a QC step
+that removes dead cells, now you also have to remember to remove that
+same set of cells from the cell-wise metadata. Dropped un-expressed
+genes? Don’t forget to filter the gene metadata table too.</p></li>
+<li><p>All the downstream steps have to be “from scratch” as well! All
+the data munging, analysis, and visualization code has to be customized
+to the idiosyncrasies of your input. Agh!</p></li>
+</ol></div>
+</div>
+</div>
+</div>
 <div id="further-reading" class="callout checklist">
 <div class="callout-square">
 <i class="callout-icon" data-feather="check-square"></i>
@@ -958,8 +980,8 @@ <h3 class="callout-title">Key Points</h3>
   "url": "https://ccb-hms.github.io/osca-carpentries/instructor/intro-sce.html",
   "identifier": "https://ccb-hms.github.io/osca-carpentries/instructor/intro-sce.html",
   "dateCreated": "2024-01-10",
-  "dateModified": "2024-09-13",
-  "datePublished": "2024-09-13"
+  "dateModified": "2024-09-16",
+  "datePublished": "2024-09-16"
 }
 
   </script><script>
diff --git a/instructor/key-points.html b/instructor/key-points.html
index 0f70c2f..a212da7 100644
--- a/instructor/key-points.html
+++ b/instructor/key-points.html
@@ -540,8 +540,8 @@ <h2 class="accordion-header" id="flush-headingTwelve">
   "url": "https://ccb-hms.github.io/osca-carpentries/instructor/key-points.html",
   "identifier": "https://ccb-hms.github.io/osca-carpentries/instructor/key-points.html",
   "dateCreated": "2024-01-10",
-  "dateModified": "2024-09-13",
-  "datePublished": "2024-09-13"
+  "dateModified": "2024-09-16",
+  "datePublished": "2024-09-16"
 }
 
   </script><script>
diff --git a/instructor/large_data.html b/instructor/large_data.html
index 0e49744..8514606 100644
--- a/instructor/large_data.html
+++ b/instructor/large_data.html
@@ -1610,7 +1610,7 @@ <h3 class="callout-title">Key Points</h3>
   "identifier": "https://ccb-hms.github.io/osca-carpentries/instructor/large_data.html",
   "dateCreated": "2024-01-10",
   "dateModified": "2024-09-09",
-  "datePublished": "2024-09-13"
+  "datePublished": "2024-09-16"
 }
 
   </script><script>
diff --git a/instructor/multi-sample.html b/instructor/multi-sample.html
index 77465ce..cb8f7f4 100644
--- a/instructor/multi-sample.html
+++ b/instructor/multi-sample.html
@@ -545,7 +545,7 @@ <h3 class="callout-title">Challenge</h3>
 <button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution1" aria-expanded="false" aria-controls="collapseSolution1">
   <h4 class="accordion-header" id="headingSolution1"> Show me the solution </h4>
 </button>
-<div id="collapseSolution1" class="accordion-collapse collapse" aria-labelledby="headingSolution1" data-bs-parent="#accordionSolution1">
+<div id="collapseSolution1" class="accordion-collapse collapse" data-bs-parent="#accordionSolution1" aria-labelledby="headingSolution1">
 <div class="accordion-body">
 <p>Samples 5 and 6 were from the same “pool” of cells. Looking at the
 documentation for the dataset under <code>?WTChimeraData</code> we see
@@ -609,7 +609,7 @@ <h3 class="callout-title">Challenge</h3>
 <button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution2" aria-expanded="false" aria-controls="collapseSolution2">
   <h4 class="accordion-header" id="headingSolution2"> Show me the solution </h4>
 </button>
-<div id="collapseSolution2" class="accordion-collapse collapse" aria-labelledby="headingSolution2" data-bs-parent="#accordionSolution2">
+<div id="collapseSolution2" class="accordion-collapse collapse" data-bs-parent="#accordionSolution2" aria-labelledby="headingSolution2">
 <div class="accordion-body">
 <p>It’s important to have multiple samples within each experimental
 group because it helps the batch effect correction algorithm distinguish
@@ -1059,7 +1059,7 @@ <h3 class="callout-title">Challenge</h3>
 <button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution3" aria-expanded="false" aria-controls="collapseSolution3">
   <h4 class="accordion-header" id="headingSolution3"> Show me the solution </h4>
 </button>
-<div id="collapseSolution3" class="accordion-collapse collapse" aria-labelledby="headingSolution3" data-bs-parent="#accordionSolution3">
+<div id="collapseSolution3" class="accordion-collapse collapse" data-bs-parent="#accordionSolution3" aria-labelledby="headingSolution3">
 <div class="accordion-body">
 <p>“logFC” stands for log fold-change. Rather than reporting e.g. a
 5-fold increase, it’s better to report a logFC of log(5) = 1.61.
@@ -1376,7 +1376,7 @@ <h3 class="callout-title">Exercise 1: Replicates</h3>
 <button class="accordion-button hint-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseHint1" aria-expanded="false" aria-controls="collapseHint1">
   <h4 class="accordion-header" id="headingHint1"> Give me a hint </h4>
 </button>
-<div id="collapseHint1" class="accordion-collapse collapse" aria-labelledby="headingHint1" data-bs-parent="#accordionHint1">
+<div id="collapseHint1" class="accordion-collapse collapse" data-bs-parent="#accordionHint1" aria-labelledby="headingHint1">
 <div class="accordion-body">
 <p>Remember, you can subset SingleCellExperiments with logical indices,
 just like a matrix. You can also access their column data with the
@@ -1390,7 +1390,7 @@ <h4 class="accordion-header" id="headingHint1"> Give me a hint </h4>
 <button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution4" aria-expanded="false" aria-controls="collapseSolution4">
   <h4 class="accordion-header" id="headingSolution4"> Show me the solution </h4>
 </button>
-<div id="collapseSolution4" class="accordion-collapse collapse" aria-labelledby="headingSolution4" data-bs-parent="#accordionSolution4">
+<div id="collapseSolution4" class="accordion-collapse collapse" data-bs-parent="#accordionSolution4" aria-labelledby="headingSolution4">
 <div class="accordion-body">
 <div class="codewrapper sourceCode" id="cb52">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
@@ -1427,7 +1427,7 @@ <h3 class="callout-title">Exercise 2:</h3>
 <button class="accordion-button hint-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseHint2" aria-expanded="false" aria-controls="collapseHint2">
   <h4 class="accordion-header" id="headingHint2"> Give me a hint </h4>
 </button>
-<div id="collapseHint2" class="accordion-collapse collapse" aria-labelledby="headingHint2" data-bs-parent="#accordionHint2">
+<div id="collapseHint2" class="accordion-collapse collapse" data-bs-parent="#accordionHint2" aria-labelledby="headingHint2">
 <div class="accordion-body">
 <p>You can just hand <code>pheatmap()</code> a matrix as its only
 argument. It has a million options, but the defaults are usually pretty
@@ -1441,7 +1441,7 @@ <h4 class="accordion-header" id="headingHint2"> Give me a hint </h4>
 <button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution5" aria-expanded="false" aria-controls="collapseSolution5">
   <h4 class="accordion-header" id="headingSolution5"> Show me the solution </h4>
 </button>
-<div id="collapseSolution5" class="accordion-collapse collapse" aria-labelledby="headingSolution5" data-bs-parent="#accordionSolution5">
+<div id="collapseSolution5" class="accordion-collapse collapse" data-bs-parent="#accordionSolution5" aria-labelledby="headingSolution5">
 <div class="accordion-body">
 <div class="codewrapper sourceCode" id="cb53">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
@@ -1567,7 +1567,7 @@ <h3 class="callout-title">Key Points</h3>
   "identifier": "https://ccb-hms.github.io/osca-carpentries/instructor/multi-sample.html",
   "dateCreated": "2024-01-10",
   "dateModified": "2024-09-08",
-  "datePublished": "2024-09-13"
+  "datePublished": "2024-09-16"
 }
 
   </script><script>
diff --git a/instructor/profiles.html b/instructor/profiles.html
index 54a0cae..97b91bc 100644
--- a/instructor/profiles.html
+++ b/instructor/profiles.html
@@ -370,8 +370,8 @@ <h1>Learner Profiles</h1>
   "url": "https://ccb-hms.github.io/osca-carpentries/instructor/profiles.html",
   "identifier": "https://ccb-hms.github.io/osca-carpentries/instructor/profiles.html",
   "dateCreated": "2024-01-10",
-  "dateModified": "2024-09-13",
-  "datePublished": "2024-09-13"
+  "dateModified": "2024-09-16",
+  "datePublished": "2024-09-16"
 }
 
   </script><script>
diff --git a/instructor/reference.html b/instructor/reference.html
index 8aef5fb..e40a4d6 100644
--- a/instructor/reference.html
+++ b/instructor/reference.html
@@ -413,7 +413,7 @@ <h1>Reference</h1>
   "identifier": "https://ccb-hms.github.io/osca-carpentries/instructor/reference.html",
   "dateCreated": "2024-01-10",
   "dateModified": "2024-09-06",
-  "datePublished": "2024-09-13"
+  "datePublished": "2024-09-16"
 }
 
   </script><script>
diff --git a/intro-sce.html b/intro-sce.html
index 9d08a9b..b8c1065 100644
--- a/intro-sce.html
+++ b/intro-sce.html
@@ -327,7 +327,7 @@ <h2 class="accordion-header" id="flush-headingTwelve">
       </div>
       <hr></nav><main id="main-content" class="main-content"><div class="container lesson-content">
         <h1>Introduction to Bioconductor and the SingleCellExperiment class</h1>
-        <p>Last updated on 2024-09-13 |
+        <p>Last updated on 2024-09-16 |
 
         <a href="https://github.com/ccb-hms/osca-carpentries/edit/main/episodes/intro-sce.Rmd" class="external-link">Edit this page <i aria-hidden="true" data-feather="edit"></i></a></p>
 
@@ -524,39 +524,28 @@ <h3 class="code-label">OUTPUT<i aria-hidden="true" data-feather="chevron-left"><
 (e.g., numeric matrices, lists, etc.). Here we’ll review the main slots
 of the SingleCellExperiment class as well as their getter/setter
 methods.</p>
-<div id="challenge1" class="callout challenge">
+<div id="discussion1" class="callout discussion">
 <div class="callout-square">
-<i class="callout-icon" data-feather="zap"></i>
+<i class="callout-icon" data-feather="message-circle"></i>
 </div>
 <div class="callout-inner">
 <h3 class="callout-title">Challenge</h3>
 <div class="callout-content">
-<p>Before <code>SingleCellExperiment</code>, coders working with single
-cell data would sometimes keep all of these components in separate
-objects e.g. a matrix of counts, a data.frame of sample metadata, a
-data.frame of gene annotations and so on. What are the main
-disadvantages of this sort of “from scratch” approach?</p>
+<p>Try to get the data for a different sample from
+<code>WTChimeraData</code> (other than the fifth one) ::: solution</p>
+<p>Here we assign the sixth sample to <code>sce6</code>:</p>
+<div class="codewrapper sourceCode" id="cb9">
+<h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
+</h3>
+<pre class="downlit sourceCode r">
+<code class="sourceCode R"><span><span class="va">sce6</span> <span class="op">&lt;-</span> <span class="fu">WTChimeraData</span><span class="op">(</span>samples <span class="op">=</span> <span class="fl">6</span><span class="op">)</span></span>
+<span></span>
+<span><span class="va">sce6</span></span></code></pre>
 </div>
 </div>
 </div>
-<div id="accordionSolution1" class="accordion challenge-accordion accordion-flush">
-<div class="accordion-item">
-<button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution1" aria-expanded="false" aria-controls="collapseSolution1">
-  <h4 class="accordion-header" id="headingSolution1"> Show me the solution </h4>
-</button>
-<div id="collapseSolution1" class="accordion-collapse collapse" data-bs-parent="#accordionSolution1" aria-labelledby="headingSolution1">
-<div class="accordion-body">
-<ol style="list-style-type: decimal"><li><p>You have to do tons of book-keeping! If you perform a QC step
-that removes dead cells, now you also have to remember to remove that
-same set of cells from the cell-wise metadata. Dropped un-expressed
-genes? Don’t forget to filter the gene metadata table too.</p></li>
-<li><p>All the downstream steps have to be “from scratch” as well! All
-the data munging, analysis, and visualization code has to be customized
-to the idiosyncrasies of your input. Agh!</p></li>
-</ol></div>
-</div>
-</div>
 </div>
+<p>::::</p>
 </div>
 <div class="section level3">
 <h3 id="assays"><code>assays</code><a class="anchor" aria-label="anchor" href="#assays"></a></h3>
@@ -567,7 +556,7 @@ <h3 id="assays"><code>assays</code><a class="anchor" aria-label="anchor" href="#
 <code>assay</code> function. If one of these matrices is called
 “counts”, we can use the special <code>counts</code> getter (likewise
 for <code>logcounts</code>).</p>
-<div class="codewrapper sourceCode" id="cb9">
+<div class="codewrapper sourceCode" id="cb10">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
 </h3>
 <pre class="downlit sourceCode r">
@@ -578,7 +567,7 @@ <h3 class="code-label">OUTPUT<i aria-hidden="true" data-feather="chevron-left"><
 </h3>
 <pre class="output" tabindex="0"><code>[1] "counts"</code></pre>
 </div>
-<div class="codewrapper sourceCode" id="cb11">
+<div class="codewrapper sourceCode" id="cb12">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
 </h3>
 <pre class="downlit sourceCode r">
@@ -606,7 +595,7 @@ <h3 id="coldata-and-rowdata">
 the rows of your assay, respectively.</p>
 <p>One can interact with them as usual, e.g., by extracting columns or
 adding additional variables as columns.</p>
-<div class="codewrapper sourceCode" id="cb13">
+<div class="codewrapper sourceCode" id="cb14">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
 </h3>
 <pre class="downlit sourceCode r">
@@ -622,7 +611,7 @@ <h3 class="code-label">OUTPUT<i aria-hidden="true" data-feather="chevron-left"><
 cell_9770   cell_9770 AAACCTGAGATGCCTT         5        E8.5
 cell_9771   cell_9771 AAACCTGAGCAGCCTC         5        E8.5</code></pre>
 </div>
-<div class="codewrapper sourceCode" id="cb15">
+<div class="codewrapper sourceCode" id="cb16">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
 </h3>
 <pre class="downlit sourceCode r">
@@ -640,7 +629,7 @@ <h3 class="code-label">OUTPUT<i aria-hidden="true" data-feather="chevron-left"><
 </div>
 <p>You can access columns of the colData with the <code>$</code>
 accessor to quickly add cell-wise metadata to the colData</p>
-<div class="codewrapper sourceCode" id="cb17">
+<div class="codewrapper sourceCode" id="cb18">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
 </h3>
 <pre class="downlit sourceCode r">
@@ -668,7 +657,7 @@ <h3 class="code-label">OUTPUT<i aria-hidden="true" data-feather="chevron-left"><
 cell_9770    1.22757     29309
 cell_9771    1.15439     28795</code></pre>
 </div>
-<div id="challenge2" class="callout challenge">
+<div id="challenge1" class="callout challenge">
 <div class="callout-square">
 <i class="callout-icon" data-feather="zap"></i>
 </div>
@@ -679,16 +668,16 @@ <h3 class="callout-title">Challenge</h3>
 </div>
 </div>
 </div>
-<div id="accordionSolution2" class="accordion challenge-accordion accordion-flush">
+<div id="accordionSolution1" class="accordion challenge-accordion accordion-flush">
 <div class="accordion-item">
-<button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution2" aria-expanded="false" aria-controls="collapseSolution2">
-  <h4 class="accordion-header" id="headingSolution2"> Show me the solution </h4>
+<button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution1" aria-expanded="false" aria-controls="collapseSolution1">
+  <h4 class="accordion-header" id="headingSolution1"> Show me the solution </h4>
 </button>
-<div id="collapseSolution2" class="accordion-collapse collapse" data-bs-parent="#accordionSolution2" aria-labelledby="headingSolution2">
+<div id="collapseSolution1" class="accordion-collapse collapse" data-bs-parent="#accordionSolution1" aria-labelledby="headingSolution1">
 <div class="accordion-body">
 <p>Here we add a column called “conservation” that is just an integer
 sequence from 1 to the number of genes.</p>
-<div class="codewrapper sourceCode" id="cb19">
+<div class="codewrapper sourceCode" id="cb20">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
 </h3>
 <pre class="downlit sourceCode r">
@@ -714,7 +703,7 @@ <h3 id="the-reduceddims">The <code>reducedDims</code>
 <p>One peculiarity of <code>SingleCellExperiment</code> is its ability
 to store reduced dimension matrices within the object. These may include
 PCA, t-SNE, UMAP, etc.</p>
-<div class="codewrapper sourceCode" id="cb20">
+<div class="codewrapper sourceCode" id="cb21">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
 </h3>
 <pre class="downlit sourceCode r">
@@ -736,7 +725,7 @@ <h3 class="code-label">OUTPUT<i aria-hidden="true" data-feather="chevron-left"><
 <em>indirectly</em> from the objects. Note that one could obtain the
 same results (somewhat less efficiently) by extracting the corresponding
 <code>reducedDim</code> matrix and <code>ggplot</code>.</p>
-<div class="codewrapper sourceCode" id="cb22">
+<div class="codewrapper sourceCode" id="cb23">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
 </h3>
 <pre class="downlit sourceCode r">
@@ -744,7 +733,7 @@ <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i
 <span></span>
 <span><span class="fu">plotReducedDim</span><span class="op">(</span><span class="va">sce</span>, <span class="st">"pca.corrected.E8.5"</span>, colour_by <span class="op">=</span> <span class="st">"celltype.mapped"</span><span class="op">)</span></span></code></pre>
 </div>
-<figure><img src="fig/intro-sce-rendered-unnamed-chunk-13-1.png" style="display: block; margin: auto;" class="figure mx-auto d-block"></figure><div id="exercise-1" class="callout challenge">
+<figure><img src="fig/intro-sce-rendered-unnamed-chunk-14-1.png" style="display: block; margin: auto;" class="figure mx-auto d-block"></figure><div id="exercise-1" class="callout challenge">
 <div class="callout-square">
 <i class="callout-icon" data-feather="zap"></i>
 </div>
@@ -771,14 +760,14 @@ <h4 class="accordion-header" id="headingHint1"> Give me a hint </h4>
 </div>
 </div>
 </div>
-<div id="accordionSolution3" class="accordion challenge-accordion accordion-flush">
+<div id="accordionSolution2" class="accordion challenge-accordion accordion-flush">
 <div class="accordion-item">
-<button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution3" aria-expanded="false" aria-controls="collapseSolution3">
-  <h4 class="accordion-header" id="headingSolution3"> Show me the solution </h4>
+<button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution2" aria-expanded="false" aria-controls="collapseSolution2">
+  <h4 class="accordion-header" id="headingSolution2"> Show me the solution </h4>
 </button>
-<div id="collapseSolution3" class="accordion-collapse collapse" data-bs-parent="#accordionSolution3" aria-labelledby="headingSolution3">
+<div id="collapseSolution2" class="accordion-collapse collapse" data-bs-parent="#accordionSolution2" aria-labelledby="headingSolution2">
 <div class="accordion-body">
-<div class="codewrapper sourceCode" id="cb23">
+<div class="codewrapper sourceCode" id="cb24">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
 </h3>
 <pre class="downlit sourceCode r">
@@ -824,14 +813,14 @@ <h3 class="callout-title">Exercise 2</h3>
 </div>
 </div>
 </div>
-<div id="accordionSolution4" class="accordion challenge-accordion accordion-flush">
+<div id="accordionSolution3" class="accordion challenge-accordion accordion-flush">
 <div class="accordion-item">
-<button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution4" aria-expanded="false" aria-controls="collapseSolution4">
-  <h4 class="accordion-header" id="headingSolution4"> Show me the solution </h4>
+<button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution3" aria-expanded="false" aria-controls="collapseSolution3">
+  <h4 class="accordion-header" id="headingSolution3"> Show me the solution </h4>
 </button>
-<div id="collapseSolution4" class="accordion-collapse collapse" data-bs-parent="#accordionSolution4" aria-labelledby="headingSolution4">
+<div id="collapseSolution3" class="accordion-collapse collapse" data-bs-parent="#accordionSolution3" aria-labelledby="headingSolution3">
 <div class="accordion-body">
-<div class="codewrapper sourceCode" id="cb25">
+<div class="codewrapper sourceCode" id="cb26">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
 </h3>
 <pre class="downlit sourceCode r">
@@ -863,6 +852,39 @@ <h3 class="code-label">OUTPUT<i aria-hidden="true" data-feather="chevron-left"><
 </div>
 </div>
 </div>
+<div id="extension-challenge-1" class="callout challenge">
+<div class="callout-square">
+<i class="callout-icon" data-feather="zap"></i>
+</div>
+<div id="extension-challenge-1" class="callout-inner">
+<h3 class="callout-title">Extension Challenge 1</h3>
+<div class="callout-content">
+<p>Before <code>SingleCellExperiment</code>, coders working with single
+cell data would sometimes keep all of these components in separate
+objects e.g. a matrix of counts, a data.frame of sample metadata, a
+data.frame of gene annotations and so on. What are the main
+disadvantages of this sort of “from scratch” approach?</p>
+</div>
+</div>
+</div>
+<div id="accordionSolution4" class="accordion challenge-accordion accordion-flush">
+<div class="accordion-item">
+<button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution4" aria-expanded="false" aria-controls="collapseSolution4">
+  <h4 class="accordion-header" id="headingSolution4"> Show me the solution </h4>
+</button>
+<div id="collapseSolution4" class="accordion-collapse collapse" data-bs-parent="#accordionSolution4" aria-labelledby="headingSolution4">
+<div class="accordion-body">
+<ol style="list-style-type: decimal"><li><p>You have to do tons of book-keeping! If you perform a QC step
+that removes dead cells, now you also have to remember to remove that
+same set of cells from the cell-wise metadata. Dropped un-expressed
+genes? Don’t forget to filter the gene metadata table too.</p></li>
+<li><p>All the downstream steps have to be “from scratch” as well! All
+the data munging, analysis, and visualization code has to be customized
+to the idiosyncrasies of your input. Agh!</p></li>
+</ol></div>
+</div>
+</div>
+</div>
 <div id="further-reading" class="callout checklist">
 <div class="callout-square">
 <i class="callout-icon" data-feather="check-square"></i>
@@ -956,8 +978,8 @@ <h3 class="callout-title">Key Points</h3>
   "url": "https://ccb-hms.github.io/osca-carpentries/intro-sce.html",
   "identifier": "https://ccb-hms.github.io/osca-carpentries/intro-sce.html",
   "dateCreated": "2024-01-10",
-  "dateModified": "2024-09-13",
-  "datePublished": "2024-09-13"
+  "dateModified": "2024-09-16",
+  "datePublished": "2024-09-16"
 }
 
   </script><script>
diff --git a/key-points.html b/key-points.html
index 5f0b434..83ee5ab 100644
--- a/key-points.html
+++ b/key-points.html
@@ -538,8 +538,8 @@ <h2 class="accordion-header" id="flush-headingTwelve">
   "url": "https://ccb-hms.github.io/osca-carpentries/key-points.html",
   "identifier": "https://ccb-hms.github.io/osca-carpentries/key-points.html",
   "dateCreated": "2024-01-10",
-  "dateModified": "2024-09-13",
-  "datePublished": "2024-09-13"
+  "dateModified": "2024-09-16",
+  "datePublished": "2024-09-16"
 }
 
   </script><script>
diff --git a/large_data.html b/large_data.html
index 3035dba..7a45c79 100644
--- a/large_data.html
+++ b/large_data.html
@@ -1608,7 +1608,7 @@ <h3 class="callout-title">Key Points</h3>
   "identifier": "https://ccb-hms.github.io/osca-carpentries/large_data.html",
   "dateCreated": "2024-01-10",
   "dateModified": "2024-09-09",
-  "datePublished": "2024-09-13"
+  "datePublished": "2024-09-16"
 }
 
   </script><script>
diff --git a/md5sum.txt b/md5sum.txt
index 4c7dd28..b9507b3 100644
--- a/md5sum.txt
+++ b/md5sum.txt
@@ -4,13 +4,13 @@
 "config.yaml" "b0d664d3d6abdd0e98b16282e1c03107" "site/built/config.yaml" "2024-09-06"
 "index.md" "495939ddd3f110be3bbcd49b60f4a7ce" "site/built/index.md" "2024-09-06"
 "links.md" "8184cf4149eafbf03ce8da8ff0778c14" "site/built/links.md" "2024-09-06"
-"episodes/intro-sce.Rmd" "1df9dba39ca154d95e82dbeb7c43b00d" "site/built/intro-sce.md" "2024-09-13"
+"episodes/intro-sce.Rmd" "e0218183fa139dbe5adbc2ed0b02b8c0" "site/built/intro-sce.md" "2024-09-16"
 "episodes/eda_qc.Rmd" "1e88f395d30778f4526532deea43eb03" "site/built/eda_qc.md" "2024-09-06"
 "episodes/cell_type_annotation.Rmd" "66af56b730aaa88e937bc1743afb471a" "site/built/cell_type_annotation.md" "2024-09-08"
 "episodes/multi-sample.Rmd" "2d38d9903358ea8a8067abd82a1f1f54" "site/built/multi-sample.md" "2024-09-08"
 "episodes/large_data.Rmd" "b9710492c6792ea435778c4e42f27e02" "site/built/large_data.md" "2024-09-09"
 "episodes/hca.Rmd" "e01d3fd1e07f158bed08b72d657ae1d1" "site/built/hca.md" "2024-09-09"
-"instructors/instructor-notes.md" "cae72b6712578d74a49fea7513099f8c" "site/built/instructor-notes.md" "2024-09-06"
+"instructors/instructor-notes.md" "205339793f625a1844a768dea8e4a9c8" "site/built/instructor-notes.md" "2024-09-16"
 "learners/reference.md" "40fc1d0be2412d2d9d434a5bc84e4de8" "site/built/reference.md" "2024-09-06"
 "learners/setup.md" "25772142a26fe3c0cebbe650f5683269" "site/built/setup.md" "2024-09-06"
 "profiles/learner-profiles.md" "074074346a544b8d2e0774998781c5d4" "site/built/learner-profiles.md" "2024-09-13"
diff --git a/multi-sample.html b/multi-sample.html
index f712b3f..a7ac908 100644
--- a/multi-sample.html
+++ b/multi-sample.html
@@ -543,7 +543,7 @@ <h3 class="callout-title">Challenge</h3>
 <button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution1" aria-expanded="false" aria-controls="collapseSolution1">
   <h4 class="accordion-header" id="headingSolution1"> Show me the solution </h4>
 </button>
-<div id="collapseSolution1" class="accordion-collapse collapse" aria-labelledby="headingSolution1" data-bs-parent="#accordionSolution1">
+<div id="collapseSolution1" class="accordion-collapse collapse" data-bs-parent="#accordionSolution1" aria-labelledby="headingSolution1">
 <div class="accordion-body">
 <p>Samples 5 and 6 were from the same “pool” of cells. Looking at the
 documentation for the dataset under <code>?WTChimeraData</code> we see
@@ -607,7 +607,7 @@ <h3 class="callout-title">Challenge</h3>
 <button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution2" aria-expanded="false" aria-controls="collapseSolution2">
   <h4 class="accordion-header" id="headingSolution2"> Show me the solution </h4>
 </button>
-<div id="collapseSolution2" class="accordion-collapse collapse" aria-labelledby="headingSolution2" data-bs-parent="#accordionSolution2">
+<div id="collapseSolution2" class="accordion-collapse collapse" data-bs-parent="#accordionSolution2" aria-labelledby="headingSolution2">
 <div class="accordion-body">
 <p>It’s important to have multiple samples within each experimental
 group because it helps the batch effect correction algorithm distinguish
@@ -1057,7 +1057,7 @@ <h3 class="callout-title">Challenge</h3>
 <button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution3" aria-expanded="false" aria-controls="collapseSolution3">
   <h4 class="accordion-header" id="headingSolution3"> Show me the solution </h4>
 </button>
-<div id="collapseSolution3" class="accordion-collapse collapse" aria-labelledby="headingSolution3" data-bs-parent="#accordionSolution3">
+<div id="collapseSolution3" class="accordion-collapse collapse" data-bs-parent="#accordionSolution3" aria-labelledby="headingSolution3">
 <div class="accordion-body">
 <p>“logFC” stands for log fold-change. Rather than reporting e.g. a
 5-fold increase, it’s better to report a logFC of log(5) = 1.61.
@@ -1374,7 +1374,7 @@ <h3 class="callout-title">Exercise 1: Replicates</h3>
 <button class="accordion-button hint-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseHint1" aria-expanded="false" aria-controls="collapseHint1">
   <h4 class="accordion-header" id="headingHint1"> Give me a hint </h4>
 </button>
-<div id="collapseHint1" class="accordion-collapse collapse" aria-labelledby="headingHint1" data-bs-parent="#accordionHint1">
+<div id="collapseHint1" class="accordion-collapse collapse" data-bs-parent="#accordionHint1" aria-labelledby="headingHint1">
 <div class="accordion-body">
 <p>Remember, you can subset SingleCellExperiments with logical indices,
 just like a matrix. You can also access their column data with the
@@ -1388,7 +1388,7 @@ <h4 class="accordion-header" id="headingHint1"> Give me a hint </h4>
 <button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution4" aria-expanded="false" aria-controls="collapseSolution4">
   <h4 class="accordion-header" id="headingSolution4"> Show me the solution </h4>
 </button>
-<div id="collapseSolution4" class="accordion-collapse collapse" aria-labelledby="headingSolution4" data-bs-parent="#accordionSolution4">
+<div id="collapseSolution4" class="accordion-collapse collapse" data-bs-parent="#accordionSolution4" aria-labelledby="headingSolution4">
 <div class="accordion-body">
 <div class="codewrapper sourceCode" id="cb52">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
@@ -1425,7 +1425,7 @@ <h3 class="callout-title">Exercise 2:</h3>
 <button class="accordion-button hint-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseHint2" aria-expanded="false" aria-controls="collapseHint2">
   <h4 class="accordion-header" id="headingHint2"> Give me a hint </h4>
 </button>
-<div id="collapseHint2" class="accordion-collapse collapse" aria-labelledby="headingHint2" data-bs-parent="#accordionHint2">
+<div id="collapseHint2" class="accordion-collapse collapse" data-bs-parent="#accordionHint2" aria-labelledby="headingHint2">
 <div class="accordion-body">
 <p>You can just hand <code>pheatmap()</code> a matrix as its only
 argument. It has a million options, but the defaults are usually pretty
@@ -1439,7 +1439,7 @@ <h4 class="accordion-header" id="headingHint2"> Give me a hint </h4>
 <button class="accordion-button solution-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseSolution5" aria-expanded="false" aria-controls="collapseSolution5">
   <h4 class="accordion-header" id="headingSolution5"> Show me the solution </h4>
 </button>
-<div id="collapseSolution5" class="accordion-collapse collapse" aria-labelledby="headingSolution5" data-bs-parent="#accordionSolution5">
+<div id="collapseSolution5" class="accordion-collapse collapse" data-bs-parent="#accordionSolution5" aria-labelledby="headingSolution5">
 <div class="accordion-body">
 <div class="codewrapper sourceCode" id="cb53">
 <h3 class="code-label">R<i aria-hidden="true" data-feather="chevron-left"></i><i aria-hidden="true" data-feather="chevron-right"></i>
@@ -1565,7 +1565,7 @@ <h3 class="callout-title">Key Points</h3>
   "identifier": "https://ccb-hms.github.io/osca-carpentries/multi-sample.html",
   "dateCreated": "2024-01-10",
   "dateModified": "2024-09-08",
-  "datePublished": "2024-09-13"
+  "datePublished": "2024-09-16"
 }
 
   </script><script>
diff --git a/pkgdown.yml b/pkgdown.yml
index e200416..b7f7ccf 100644
--- a/pkgdown.yml
+++ b/pkgdown.yml
@@ -2,4 +2,4 @@ pandoc: 3.1.11
 pkgdown: 2.1.0
 pkgdown_sha: ~
 articles: {}
-last_built: 2024-09-13T17:57Z
+last_built: 2024-09-16T17:04Z
diff --git a/profiles.html b/profiles.html
index cd15141..9e596a5 100644
--- a/profiles.html
+++ b/profiles.html
@@ -370,8 +370,8 @@ <h1>Learner Profiles</h1>
   "url": "https://ccb-hms.github.io/osca-carpentries/profiles.html",
   "identifier": "https://ccb-hms.github.io/osca-carpentries/profiles.html",
   "dateCreated": "2024-01-10",
-  "dateModified": "2024-09-13",
-  "datePublished": "2024-09-13"
+  "dateModified": "2024-09-16",
+  "datePublished": "2024-09-16"
 }
 
   </script><script>
diff --git a/reference.html b/reference.html
index 9cea4e4..572da95 100644
--- a/reference.html
+++ b/reference.html
@@ -411,7 +411,7 @@ <h1>Reference</h1>
   "identifier": "https://ccb-hms.github.io/osca-carpentries/reference.html",
   "dateCreated": "2024-01-10",
   "dateModified": "2024-09-06",
-  "datePublished": "2024-09-13"
+  "datePublished": "2024-09-16"
 }
 
   </script><script>