Spacing function in Autodock Vina

[adilsaeed45]

Hello,

In old versions of Vina there was no option to set spacing value when docking was being done (default was 1 as per manual). As per manual, we used to set the spacing in grid box view of MGL tools at 1 (makes the box bigger)

Now in help of new version of Vina there is an option of setting spacing (default seems to be 0.375 as per value in bracket).
Do we need to specify spacing as 1A in config file to keep it as 1? and can Vina now use spacing of 0.375A and we can take grid box values at 0.375A?

Please also provide link of any updated manual also which can be referred for new functions of Vina,

Regards

[diogomart]

Hello,

In Vina, the box dimensions are set in Angstroms, regardless of the spacing. The number of grid points is then calculated internally.

[diogomart]

Setting a spacing greater than 0.375 is too coarse and will likely result in worse performance.