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Feature request: Option to use nlmixr2 instead of NONMEM? #14

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billdenney opened this issue Jun 19, 2024 · 0 comments
Open

Feature request: Option to use nlmixr2 instead of NONMEM? #14

billdenney opened this issue Jun 19, 2024 · 0 comments

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@billdenney
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In the process of releasing a new version of PKNCA (don't worry, no breakage is expected), I found this package.

I had been wanting to make an MBBE package, so it was great to see that someone had beaten me to it!

That said, my workflow is now almost fully focused on nlmixr2 these days, and it seems like integration here could be a good fit so that the entire MBBE evaluation could happen in R. In addition, typical models (i.e. 1-, 2-, and 3-compartment models) could be sourced from the nlmixr2lib package and automatic parameter initialization could happen via babelmixr2 (where PKNCA is used to provide reasonable initial estimates for 1-, 2-, and 3-compartment models).

Would you be interested in linking this to nlmixr2? For clarity, I'm not suggesting replacing NONMEM with nlmixr2 but adding another option.

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