From 2d9941872031c3c82e839e5f1a6ee220d64dbf68 Mon Sep 17 00:00:00 2001 From: axelvonkamp <47664585+axelvonkamp@users.noreply.github.com> Date: Thu, 13 Oct 2022 14:22:10 +0200 Subject: [PATCH] C necator (#12) * Cupriavidus necator model based on iCN1361 * RehMBEL1391 model as updated by Jahn * core model by Janasch --- .../PHB_from_fructose.scen | 1 + C_necator_RehMBEL1391_Jahn/box_positions.json | 1 + C_necator_RehMBEL1391_Jahn/map1.svg | 4959 + C_necator_RehMBEL1391_Jahn/map2.svg | 258 + C_necator_RehMBEL1391_Jahn/meta.json | 1 + C_necator_RehMBEL1391_Jahn/model.sbml | 106207 +++++++++++++++ C_necator_core/box_positions.json | 1 + C_necator_core/map1.svg | 105 + C_necator_core/meta.json | 1 + C_necator_core/model.sbml | 1662 + .../PHB_from_fructose+acetate.scen | 1 + C_necator_iCN1361/PHB_from_fructose.scen | 1 + C_necator_iCN1361/box_positions.json | 1 + C_necator_iCN1361/map1.svg | 4959 + C_necator_iCN1361/meta.json | 1 + C_necator_iCN1361/model.sbml | 88604 ++++++++++++ 16 files changed, 206763 insertions(+) create mode 100644 C_necator_RehMBEL1391_Jahn/PHB_from_fructose.scen create mode 100644 C_necator_RehMBEL1391_Jahn/box_positions.json create mode 100644 C_necator_RehMBEL1391_Jahn/map1.svg create mode 100644 C_necator_RehMBEL1391_Jahn/map2.svg create mode 100644 C_necator_RehMBEL1391_Jahn/meta.json create mode 100644 C_necator_RehMBEL1391_Jahn/model.sbml create mode 100644 C_necator_core/box_positions.json create mode 100644 C_necator_core/map1.svg create mode 100644 C_necator_core/meta.json create mode 100644 C_necator_core/model.sbml create mode 100644 C_necator_iCN1361/PHB_from_fructose+acetate.scen create mode 100644 C_necator_iCN1361/PHB_from_fructose.scen create mode 100644 C_necator_iCN1361/box_positions.json create mode 100644 C_necator_iCN1361/map1.svg create mode 100644 C_necator_iCN1361/meta.json create mode 100644 C_necator_iCN1361/model.sbml diff --git a/C_necator_RehMBEL1391_Jahn/PHB_from_fructose.scen b/C_necator_RehMBEL1391_Jahn/PHB_from_fructose.scen new file mode 100644 index 0000000..56eba1d --- /dev/null +++ b/C_necator_RehMBEL1391_Jahn/PHB_from_fructose.scen @@ -0,0 +1 @@ +{"fluxes": {"EX_h_e": [0, 100], "EX_h2_e": [0.0, 0.0], "EX_ac_e": [0.0, 0.0], "EX_acac_e": [0.0, 0.0], "EX_acal_e": [0.0, 0.0], "EX_ad_e": [0.0, 0.0], "EX_adn_e": [0.0, 0.0], "EX_ala__L_e": [0.0, 0.0], "EX_an_e": [0.0, 0.0], "EX_arg__L_e": [0.0, 0.0], "EX_asn__L_e": [0.0, 0.0], "EX_asp__L_e": [0.0, 0.0], "EX_ccmuc_e": [0.0, 0.0], "EX_cit_e": [0.0, 0.0], "EX_cytd_e": [0.0, 0.0], "EX_dala_e": [0.0, 0.0], "EX_eth_e": [0.0, 0.0], "EX_formate_e": [0.0, 0.0], "EX_fum_e": [0.0, 0.0], "EX_gaba_e": [0.0, 0.0], "EX_gl_e": [0.0, 0.0], "EX_glu__L_e": [0.0, 0.0], "EX_gly__L_e": [0.0, 0.0], "EX_glycolate_e": [0.0, 0.0], "EX_gn_e": [0.0, 0.0], "EX_his__L_e": [0.0, 0.0], "EX_hyxn_e": [0.0, 0.0], "EX_icit_e": [0.0, 0.0], "EX_ile__L_e": [0.0, 0.0], "EX_indole_e": [0.0, 0.0], "EX_ins_e": [0.0, 0.0], "EX_lac__D_e": [0.0, 0.0], 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itrate 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+

SUBSYSTEM: Oxidative Phosphorylation

+

PROTEIN_CLASS: 3.6.3.14

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0448 )

+

PROTEIN_ASSOCIATION: ( H16_A0448 )

+

SUBSYSTEM: Ubiquinone Biosynthesis

+

PROTEIN_CLASS: 2.7.-.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0448 )

+

PROTEIN_ASSOCIATION: ( H16_A0448 )

+

SUBSYSTEM: Ubiquinone Biosynthesis

+

PROTEIN_CLASS: 0

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2704 )

+

PROTEIN_ASSOCIATION: ( H16_A2704 )

+

SUBSYSTEM: Folate Biosynthesis

+

PROTEIN_CLASS: 1.5.1.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0448 )

+

PROTEIN_ASSOCIATION: ( H16_A0448 )

+

SUBSYSTEM: Ubiquinone Biosynthesis

+

PROTEIN_CLASS: 0

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0182 )

+

PROTEIN_ASSOCIATION: ( H16_A0182 )

+

SUBSYSTEM: Biotin Metabolism

+

PROTEIN_CLASS: 6.3.3.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Putative Transporters

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Fluorobenzoate degradation

+

PROTEIN_CLASS: 3.8.1.3

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2891 ) or ( H16_B2453 )

+

PROTEIN_ASSOCIATION: ( H16_A2891 ) or ( H16_B2453 )

+

SUBSYSTEM: Porphyrin and Chlorophyll metabolism

+

PROTEIN_CLASS: 1.3.3.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A1569 )

+

PROTEIN_ASSOCIATION: ( H16_A1569 )

+

SUBSYSTEM: Pyrimidine metabolism

+

PROTEIN_CLASS: 2.7.4.9

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1186 )

+

PROTEIN_ASSOCIATION: ( H16_A1186 )

+

SUBSYSTEM: Lipopolysaccharide Biosynthesis

+

PROTEIN_CLASS: 2.5.1.55

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 2.7.1.20

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1593 )

+

PROTEIN_ASSOCIATION: ( H16_B1593 )

+

SUBSYSTEM: Pyrimidine metabolism

+

PROTEIN_CLASS: 3.5.4.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Lipopolysaccharide Biosynthesis

+

PROTEIN_CLASS: 3.1.3.45

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A0272 )

+

PROTEIN_ASSOCIATION: ( H16_A0272 )

+

SUBSYSTEM: Valine, Leucine and Isoleucine degradation

+

PROTEIN_CLASS: 2.6.1.18

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Unassigned

+

PROTEIN_CLASS: 1.11.1.6

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1014 ) or ( H16_B2033 )

+

PROTEIN_ASSOCIATION: ( H16_A1014 ) or ( H16_B2033 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 3.5.4.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2012 )

+

PROTEIN_ASSOCIATION: ( H16_A2012 )

+

SUBSYSTEM: Pyrimidine metabolism

+

PROTEIN_CLASS: 2.4.2.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A0913 )

+

PROTEIN_ASSOCIATION: ( H16_A0913 )

+

SUBSYSTEM: Nicotinate and Nicotinamide metabolism

+

PROTEIN_CLASS: 2.7.7.18

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B0677 ) or ( H16_B2522 ) or ( H16_B1709 ) or ( H16_A1700 ) or ( H16_A2794 ) or ( H16_A2252 ) or ( H16_A2807 ) or ( H16_A1718 ) or ( H16_A0866 ) or ( H16_A0871 ) or ( H16_A1230 ) or ( H16_B0174 ) or ( H16_A1519 ) or ( H16_B1335 ) or ( H16_B0910 ) or ( H16_B1264 ) or ( H16_B1148 ) or ( H16_B1662 ) or ( H16_A2978 )

+

PROTEIN_ASSOCIATION: ( H16_B0677 ) or ( H16_B2522 ) or ( H16_B1709 ) or ( H16_A1700 ) or ( H16_A2794 ) or ( H16_A2252 ) or ( H16_A2807 ) or ( H16_A1718 ) or ( H16_A0866 ) or ( H16_A0871 ) or ( H16_A1230 ) or ( H16_B0174 ) or ( H16_A1519 ) or ( H16_B1335 ) or ( H16_B0910 ) or ( H16_B1264 ) or ( H16_B1148 ) or ( H16_B1662 ) or ( H16_A2978 )

+

SUBSYSTEM: Propanoate metabolism

+

PROTEIN_CLASS: 6.2.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3275 )

+

PROTEIN_ASSOCIATION: ( H16_A3275 )

+

SUBSYSTEM: Peptidoglycan Biosynthesis

+

PROTEIN_CLASS: 6.3.2.9

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0496 )

+

PROTEIN_ASSOCIATION: ( H16_B0496 )

+

SUBSYSTEM: Tyrosine metabolism

+

PROTEIN_CLASS: 1.14.13.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0499 ) or ( H16_A2326 )

+

PROTEIN_ASSOCIATION: ( H16_A0499 ) or ( H16_A2326 )

+

SUBSYSTEM: Glycerophospholipid Metabolism

+

PROTEIN_CLASS: 3.1.4.46

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0554 ) or ( H16_A0427 )

+

PROTEIN_ASSOCIATION: ( H16_B0554 ) or ( H16_A0427 )

+

SUBSYSTEM: Glycine, Serine and threonine Metabolism

+

PROTEIN_CLASS: 4.3.1.19

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3107 )

+

PROTEIN_ASSOCIATION: ( H16_A3107 )

+

SUBSYSTEM: Ubiquinone Biosynthesis

+

PROTEIN_CLASS: 2.5.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0496 )

+

PROTEIN_ASSOCIATION: ( H16_B0496 )

+

SUBSYSTEM: Tyrosine metabolism

+

PROTEIN_CLASS: 1.14.13.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0499 ) or ( H16_A2326 )

+

PROTEIN_ASSOCIATION: ( H16_A0499 ) or ( H16_A2326 )

+

SUBSYSTEM: Glycerophospholipid Metabolism

+

PROTEIN_CLASS: 3.1.4.46

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1671 )

+

PROTEIN_ASSOCIATION: ( H16_B1671 )

+

SUBSYSTEM: Tyrosine metabolism

+

PROTEIN_CLASS: 1.13.11.5

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2784 )

+

PROTEIN_ASSOCIATION: ( H16_A2784 )

+

SUBSYSTEM: Aminoacyl-tRNA Biosynthesi

+

PROTEIN_CLASS: 6.1.1.18

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0499 ) or ( H16_A2326 )

+

PROTEIN_ASSOCIATION: ( H16_A0499 ) or ( H16_A2326 )

+

SUBSYSTEM: Glycerophospholipid Metabolism

+

PROTEIN_CLASS: 3.1.4.46

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A1806 ) or ( H16_B0596 ) or ( H16_A2747 ) or ( H16_B0551 )

+

PROTEIN_ASSOCIATION: ( H16_A1806 ) or ( H16_B0596 ) or ( H16_A2747 ) or ( H16_B0551 )

+

SUBSYSTEM: Pyruvate Metabolism

+

PROTEIN_CLASS: 1.2.1.10

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0499 ) or ( H16_A2326 )

+

PROTEIN_ASSOCIATION: ( H16_A0499 ) or ( H16_A2326 )

+

SUBSYSTEM: Glycerophospholipid Metabolism

+

PROTEIN_CLASS: 3.1.4.46

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1070 ) or ( H16_B0359 ) or ( H16_A1069 ) or ( H16_A2151 ) or ( H16_A1289 ) or ( H16_A3307 ) or ( H16_B0706 )

+

PROTEIN_ASSOCIATION: ( H16_A1070 ) or ( H16_B0359 ) or ( H16_A1069 ) or ( H16_A2151 ) or ( H16_A1289 ) or ( H16_A3307 ) or ( H16_B0706 )

+

SUBSYSTEM: 1- and 2-Methylnaphthalene degradation

+

PROTEIN_CLASS: 4.2.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0499 ) or ( H16_A2326 )

+

PROTEIN_ASSOCIATION: ( H16_A0499 ) or ( H16_A2326 )

+

SUBSYSTEM: Glycerophospholipid Metabolism

+

PROTEIN_CLASS: 3.1.4.46

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3416 ) or ( H16_A1694 )

+

PROTEIN_ASSOCIATION: ( H16_A3416 ) or ( H16_A1694 )

+

SUBSYSTEM: Histidine Metabolism

+

PROTEIN_CLASS: 1.1.1.23

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2893 )

+

PROTEIN_ASSOCIATION: ( H16_A2893 )

+

SUBSYSTEM: Starch and sucrose metabolism

+

PROTEIN_CLASS: 2.7.7.33

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Oxidative Phosphorylation

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Biosynthesis of steroids

+

PROTEIN_CLASS: 2.5.1.29 2.5.1.33 2.5.1.30

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0913 )

+

PROTEIN_ASSOCIATION: ( H16_A0913 )

+

SUBSYSTEM: Nicotinate and Nicotinamide metabolism

+

PROTEIN_CLASS: 2.7.7.18

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A0501 )

+

PROTEIN_ASSOCIATION: ( H16_A0501 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 3.5.4.10

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A3415 ) or ( H16_A0793 )

+

PROTEIN_ASSOCIATION: ( H16_A3415 ) or ( H16_A0793 )

+

SUBSYSTEM: Phenylalanine, Tyrosine and Tryptophan biosynthesis

+

PROTEIN_CLASS: 2.6.1.9

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1980 ) or ( H16_A0190 ) or ( H16_A2209 ) or ( H16_A3582 ) or ( H16_A2464 ) or ( H16_A3623 )

+

PROTEIN_ASSOCIATION: ( H16_A1980 ) or ( H16_A0190 ) or ( H16_A2209 ) or ( H16_A3582 ) or ( H16_A2464 ) or ( H16_A3623 )

+

SUBSYSTEM: Pyruvate Metabolism

+

PROTEIN_CLASS: 3.1.2.6

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1083 )

+

PROTEIN_ASSOCIATION: ( H16_B1083 )

+

SUBSYSTEM: Phenylalanine metabolism

+

PROTEIN_CLASS: 1.13.11.27

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B0833 ) or ( H16_B1735 ) or ( H16_B2444 ) or ( H16_A0745 ) or ( H16_A1114 ) or ( H16_B1534 ) or ( H16_B0212 ) or ( H16_B1835 ) or ( H16_A0232 ) or ( H16_B0421 ) or ( H16_B0737 ) or ( H16_B1751 ) or ( H16_A1495 ) or ( H16_B1960 )

+

PROTEIN_ASSOCIATION: ( H16_B0833 ) or ( H16_B1735 ) or ( H16_B2444 ) or ( H16_A0745 ) or ( H16_A1114 ) or ( H16_B1534 ) or ( H16_B0212 ) or ( H16_B1835 ) or ( H16_A0232 ) or ( H16_B0421 ) or ( H16_B0737 ) or ( H16_B1751 ) or ( H16_A1495 ) or ( H16_B1960 )

+

SUBSYSTEM: Ascorbate and Aldarate metabolism

+

PROTEIN_CLASS: 1.2.1.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1083 )

+

PROTEIN_ASSOCIATION: ( H16_B1083 )

+

SUBSYSTEM: Tyrosine metabolism

+

PROTEIN_CLASS: 1.13.11.27

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1642 ) or ( H16_A1851 ) or ( H16_A2909 )

+

PROTEIN_ASSOCIATION: ( H16_B1642 ) or ( H16_A1851 ) or ( H16_A2909 )

+

SUBSYSTEM: Nucleotide sugars metabolism

+

PROTEIN_CLASS: 4.2.1.46

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3165 )

+

PROTEIN_ASSOCIATION: ( H16_A3165 )

+

SUBSYSTEM: Ubiquinone Biosynthesis

+

PROTEIN_CLASS: 4.1.3.40

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2762 )

+

PROTEIN_ASSOCIATION: ( H16_A2762 )

+

SUBSYSTEM: Glycine, Serine and threonine Metabolism

+

PROTEIN_CLASS: 4.1.2.5

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2762 )

+

PROTEIN_ASSOCIATION: ( H16_A2762 )

+

SUBSYSTEM: Glycine, Serine and threonine Metabolism

+

PROTEIN_CLASS: 4.1.2.5

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2346 )

+

PROTEIN_ASSOCIATION: ( H16_A2346 )

+

SUBSYSTEM: Pentose Phosphate Pathway

+

PROTEIN_CLASS: 2.2.1.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3434 )

+

PROTEIN_ASSOCIATION: ( H16_A3434 )

+

SUBSYSTEM: Phenylalanine, Tyrosine and Tryptophan biosynthesis

+

PROTEIN_CLASS: 4.2.3.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1632 and H16_B0800 )

+

PROTEIN_ASSOCIATION: ( H16_A1632_and_H16_B0800 )

+

SUBSYSTEM: Phenylalanine metabolism

+

PROTEIN_CLASS: 1.14.12.19

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2999 and H16_B2500 and H16_A1639 )

+

PROTEIN_ASSOCIATION: ( H16_A2999_and_H16_B2500_and_H16_A1639 )

+

SUBSYSTEM: Selenoamino acid metabolism

+

PROTEIN_CLASS: 1.8.1.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1223 ) or ( H16_A2854 ) or ( H16_B0632 )

+

PROTEIN_ASSOCIATION: ( H16_B1223 ) or ( H16_A2854 ) or ( H16_B0632 )

+

SUBSYSTEM: Rivoflavin metabolism

+

PROTEIN_CLASS: 4.1.2.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0159 )

+

PROTEIN_ASSOCIATION: ( H16_A0159 )

+

SUBSYSTEM: Aminoacyl-tRNA Biosynthesi

+

PROTEIN_CLASS: 6.1.1.19

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0351 )

+

PROTEIN_ASSOCIATION: ( H16_A0351 )

+

SUBSYSTEM: Porphyrin and Chlorophyll metabolism

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2129 ) or ( H16_B0738 ) or ( H16_B0730 )

+

PROTEIN_ASSOCIATION: ( H16_B2129 ) or ( H16_B0738 ) or ( H16_B0730 )

+

SUBSYSTEM: Naphthalene and Anthracene degradation

+

PROTEIN_CLASS: 1.14.-.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1562 )

+

PROTEIN_ASSOCIATION: ( H16_B1562 )

+

SUBSYSTEM: Starch and sucrose metabolism

+

PROTEIN_CLASS: 2.4.1.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2135 ) or ( H16_B0495 ) or ( H16_A1145 ) or ( H16_B1480 )

+

PROTEIN_ASSOCIATION: ( H16_B2135 ) or ( H16_B0495 ) or ( H16_A1145 ) or ( H16_B1480 )

+

SUBSYSTEM: Bisphenol A degradation

+

PROTEIN_CLASS: 1.14.13.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3045 )

+

PROTEIN_ASSOCIATION: ( H16_A3045 )

+

SUBSYSTEM: Rivoflavin metabolism

+

PROTEIN_CLASS: 2.7.7.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B1700 and H16_B1701 ) or ( H16_A0640 and H16_A0642 and H16_A0641 and H16_A0644 ) or ( H16_A3292 ) or ( H16_A2934 and H16_A2937 and H16_A2936 and H16_B1471 ) or ( H16_B1454 and H16_B1452 and H16_B1453 ) or ( H16_B1383 )

+

PROTEIN_ASSOCIATION: ( H16_B1700_and_H16_B1701 ) or ( H16_A0640_and_H16_A0642_and_H16_A0641_and_H16_A0644 ) or ( H16_A3292 ) or ( H16_A2934_and_H16_A2937_and_H16_A2936_and_H16_B1471 ) or ( H16_B1454_and_H16_B1452_and_H16_B1453 ) or ( H16_B1383 )

+

SUBSYSTEM: Glyoxylate and Dicarboxylate metabolism

+

PROTEIN_CLASS: 1.2.1.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A0603 )

+

PROTEIN_ASSOCIATION: ( H16_A0603 )

+

SUBSYSTEM: Nucleotide Salvage Pathway

+

PROTEIN_CLASS: 2.7.4.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2129 ) or ( H16_B0738 ) or ( H16_B0730 )

+

PROTEIN_ASSOCIATION: ( H16_B2129 ) or ( H16_B0738 ) or ( H16_B0730 )

+

SUBSYSTEM: Naphthalene and Anthracene degradation

+

PROTEIN_CLASS: 1.14.-.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A0603 )

+

PROTEIN_ASSOCIATION: ( H16_A0603 )

+

SUBSYSTEM: Nucleotide Salvage Pathway

+

PROTEIN_CLASS: 2.7.4.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A0603 )

+

PROTEIN_ASSOCIATION: ( H16_A0603 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 2.7.4.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3406 )

+

PROTEIN_ASSOCIATION: ( H16_A3406 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 3.6.1.17

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3406 )

+

PROTEIN_ASSOCIATION: ( H16_A3406 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 3.6.1.17

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1870 )

+

PROTEIN_ASSOCIATION: ( H16_B1870 )

+

SUBSYSTEM: Taurine and Hypotaurine metabolism

+

PROTEIN_CLASS: 2.3.3.15

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0734 ) or ( H16_B0731 )

+

PROTEIN_ASSOCIATION: ( H16_B0734 ) or ( H16_B0731 )

+

SUBSYSTEM: Fluorene degradation

+

PROTEIN_CLASS: 1.3.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1238 ) or ( H16_A0767 )

+

PROTEIN_ASSOCIATION: ( H16_B1238 ) or ( H16_A0767 )

+

SUBSYSTEM: Rivoflavin metabolism

+

PROTEIN_CLASS: 3.1.3.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0578 ) or ( H16_B0876 ) or ( H16_A0922 ) or ( H16_A1785 ) or ( H16_B0750 )

+

PROTEIN_ASSOCIATION: ( H16_A0578 ) or ( H16_B0876 ) or ( H16_A0922 ) or ( H16_A1785 ) or ( H16_B0750 )

+

SUBSYSTEM: Naphthalene and Anthracene degradation

+

PROTEIN_CLASS: 1.14.13.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2028 )

+

PROTEIN_ASSOCIATION: ( H16_A2028 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 6.3.5.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0459 ) or ( H16_A1454 )

+

PROTEIN_ASSOCIATION: ( H16_B0459 ) or ( H16_A1454 )

+

SUBSYSTEM: Urea Cycle and Metabolism of amino groups

+

PROTEIN_CLASS: 3.5.1.16

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0604 )

+

PROTEIN_ASSOCIATION: ( H16_A0604 )

+

SUBSYSTEM: Lipopolysaccharide Biosynthesis

+

PROTEIN_CLASS: 2.7.7.38

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0578 ) or ( H16_B0876 ) or ( H16_A0922 ) or ( H16_A1785 ) or ( H16_B0750 )

+

PROTEIN_ASSOCIATION: ( H16_A0578 ) or ( H16_B0876 ) or ( H16_A0922 ) or ( H16_A1785 ) or ( H16_B0750 )

+

SUBSYSTEM: 1- and 2-Methylnaphthalene degradation

+

PROTEIN_CLASS: 1.14.13.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0578 ) or ( H16_B0876 ) or ( H16_A0922 ) or ( H16_A1785 ) or ( H16_B0750 )

+

PROTEIN_ASSOCIATION: ( H16_A0578 ) or ( H16_B0876 ) or ( H16_A0922 ) or ( H16_A1785 ) or ( H16_B0750 )

+

SUBSYSTEM: 1- and 2-Methylnaphthalene degradation

+

PROTEIN_CLASS: 1.14.13.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0578 ) or ( H16_B0876 ) or ( H16_A0922 ) or ( H16_A1785 ) or ( H16_B0750 )

+

PROTEIN_ASSOCIATION: ( H16_A0578 ) or ( H16_B0876 ) or ( H16_A0922 ) or ( H16_A1785 ) or ( H16_B0750 )

+

SUBSYSTEM: 1- and 2-Methylnaphthalene degradation

+

PROTEIN_CLASS: 1.14.13.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0578 ) or ( H16_B0876 ) or ( H16_A0922 ) or ( H16_A1785 ) or ( H16_B0750 )

+

PROTEIN_ASSOCIATION: ( H16_A0578 ) or ( H16_B0876 ) or ( H16_A0922 ) or ( H16_A1785 ) or ( H16_B0750 )

+

SUBSYSTEM: Naphthalene and Anthracene degradation

+

PROTEIN_CLASS: 1.14.13.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3406 )

+

PROTEIN_ASSOCIATION: ( H16_A3406 )

+

SUBSYSTEM: Pyrimidine metabolism

+

PROTEIN_CLASS: 3.6.1.17

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2716 ) or ( H16_A2403 )

+

PROTEIN_ASSOCIATION: ( H16_A2716 ) or ( H16_A2403 )

+

SUBSYSTEM: Porphyrin and Chlorophyll metabolism

+

PROTEIN_CLASS: 6.1.1.17

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3339 )

+

PROTEIN_ASSOCIATION: ( H16_A3339 )

+

SUBSYSTEM: Porphyrin and Chlorophyll metabolism

+

PROTEIN_CLASS: 1.2.1.70

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2999 and H16_B2500 and H16_A1639 )

+

PROTEIN_ASSOCIATION: ( H16_A2999_and_H16_B2500_and_H16_A1639 )

+

SUBSYSTEM: Sulfur Metabolism

+

PROTEIN_CLASS: 1.8.1.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3433 )

+

PROTEIN_ASSOCIATION: ( H16_A3433 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 3.1.5.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0926 )

+

PROTEIN_ASSOCIATION: ( H16_A0926 )

+

SUBSYSTEM: Arginine and Proline metabolism

+

PROTEIN_CLASS: 3.5.1.59

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3724 ) or ( H16_A2323 ) or ( H16_A1377 ) or ( H16_B1098 )

+

PROTEIN_ASSOCIATION: ( H16_A3724 ) or ( H16_A2323 ) or ( H16_A1377 ) or ( H16_B1098 )

+

SUBSYSTEM: Glycine, Serine and threonine Metabolism

+

PROTEIN_CLASS: 1.8.1.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3433 )

+

PROTEIN_ASSOCIATION: ( H16_A3433 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 3.1.5.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0600 )

+

PROTEIN_ASSOCIATION: ( H16_B0600 )

+

SUBSYSTEM: Fluorene degradation

+

PROTEIN_CLASS: 3.7.1.8

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B1630 ) or ( H16_A0670 )

+

PROTEIN_ASSOCIATION: ( H16_B1630 ) or ( H16_A0670 )

+

SUBSYSTEM: Propanoate metabolism

+

PROTEIN_CLASS: 2.7.2.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1807 ) or ( H16_B0595 ) or ( H16_B0552 )

+

PROTEIN_ASSOCIATION: ( H16_A1807 ) or ( H16_B0595 ) or ( H16_B0552 )

+

SUBSYSTEM: Phenylalanine metabolism

+

PROTEIN_CLASS: 4.1.3.39

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A1370 )

+

PROTEIN_ASSOCIATION: ( H16_A1370 )

+

SUBSYSTEM: Folate Metabolism

+

PROTEIN_CLASS: 1.5.1.5

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2461 )

+

PROTEIN_ASSOCIATION: ( H16_A2461 )

+

SUBSYSTEM: Carbazole degradation

+

PROTEIN_CLASS: 1.14.13.40

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3139 )

+

PROTEIN_ASSOCIATION: ( H16_A3139 )

+

SUBSYSTEM: Aminoacyl-tRNA Biosynthesi

+

PROTEIN_CLASS: 6.1.1.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2461 )

+

PROTEIN_ASSOCIATION: ( H16_A2461 )

+

SUBSYSTEM: Carbazole degradation

+

PROTEIN_CLASS: 1.14.13.40

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0246 )

+

PROTEIN_ASSOCIATION: ( H16_A0246 )

+

SUBSYSTEM: Folate Metabolism

+

PROTEIN_CLASS: 1.5.1.20

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B0334 ) or ( H16_A2634 )

+

PROTEIN_ASSOCIATION: ( H16_B0334 ) or ( H16_A2634 )

+

SUBSYSTEM: Citric Acid Cycle

+

PROTEIN_CLASS: 1.1.1.37

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1831 ) or ( H16_B0891 ) or ( H16_A1204 ) or ( H16_B0213 )

+

PROTEIN_ASSOCIATION: ( H16_B1831 ) or ( H16_B0891 ) or ( H16_A1204 ) or ( H16_B0213 )

+

SUBSYSTEM: Lysine Biosynthesis

+

PROTEIN_CLASS: 4.2.1.52

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0654 )

+

PROTEIN_ASSOCIATION: ( H16_B0654 )

+

SUBSYSTEM: Biphenyl degradation

+

PROTEIN_CLASS: 1.13.11.39

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Citric Acid Cycle

+

PROTEIN_CLASS: 1.1.99.16

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0654 )

+

PROTEIN_ASSOCIATION: ( H16_B0654 )

+

SUBSYSTEM: Biphenyl degradation

+

PROTEIN_CLASS: 1.13.11.39

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B0278 ) or ( H16_B1384 ) or ( H16_A0568 )

+

PROTEIN_ASSOCIATION: ( H16_B0278 ) or ( H16_B1384 ) or ( H16_A0568 )

+

SUBSYSTEM: Glycolysis/Gluconeogenesis

+

PROTEIN_CLASS: 4.1.2.13

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Vitamine B6 metabolism

+

PROTEIN_CLASS: 1.1.1.290

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2455 )

+

PROTEIN_ASSOCIATION: ( H16_B2455 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 3.5.3.19

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2325 and H16_A2324 and H16_B1098 ) or ( H16_A3724 and H16_A2325 and H16_A2324 ) or ( H16_A2325 and H16_A2324 and H16_A1377 ) or ( H16_A2323 and H16_A2325 and H16_A2324 )

+

PROTEIN_ASSOCIATION: ( H16_A2325_and_H16_A2324_and_H16_B1098 ) or ( H16_A3724_and_H16_A2325_and_H16_A2324 ) or ( H16_A2325_and_H16_A2324_and_H16_A1377 ) or ( H16_A2323_and_H16_A2325_and_H16_A2324 )

+

SUBSYSTEM: Citric Acid Cycle

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2769 )

+

PROTEIN_ASSOCIATION: ( H16_A2769 )

+

SUBSYSTEM: Aminoacyl-tRNA Biosynthesi

+

PROTEIN_CLASS: 6.1.1.7

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2364 )

+

PROTEIN_ASSOCIATION: ( H16_A2364 )

+

SUBSYSTEM: Biosynthesis of steroids

+

PROTEIN_CLASS: 1.17.4.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1344 and H16_A1343 )

+

PROTEIN_ASSOCIATION: ( H16_A1344_and_H16_A1343 )

+

SUBSYSTEM: Aminoacyl-tRNA Biosynthesi

+

PROTEIN_CLASS: 6.1.1.20

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0671 ) or ( H16_A2352 )

+

PROTEIN_ASSOCIATION: ( H16_B0671 ) or ( H16_A2352 )

+

SUBSYSTEM: Rivoflavin metabolism

+

PROTEIN_CLASS: 1.5.1.30

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1070 ) or ( H16_B0359 ) or ( H16_A1069 ) or ( H16_A2151 ) or ( H16_A1289 ) or ( H16_A3307 ) or ( H16_B0706 )

+

PROTEIN_ASSOCIATION: ( H16_A1070 ) or ( H16_B0359 ) or ( H16_A1069 ) or ( H16_A2151 ) or ( H16_A1289 ) or ( H16_A3307 ) or ( H16_B0706 )

+

SUBSYSTEM: 1- and 2-Methylnaphthalene degradation

+

PROTEIN_CLASS: 4.2.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Putative Transporters

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1438 ) or ( H16_B0928 )

+

PROTEIN_ASSOCIATION: ( H16_B1438 ) or ( H16_B0928 )

+

SUBSYSTEM: Biotin Metabolism

+

PROTEIN_CLASS: 6.2.1.14

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1167 )

+

PROTEIN_ASSOCIATION: ( H16_A1167 )

+

SUBSYSTEM: Aminoacyl-tRNA Biosynthesi

+

PROTEIN_CLASS: 6.1.1.6

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3136 )

+

PROTEIN_ASSOCIATION: ( H16_A3136 )

+

SUBSYSTEM: Urea Cycle and Metabolism of amino groups

+

PROTEIN_CLASS: 1.2.1.41

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Tryptophan metabolism

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1390 ) or ( H16_A0999 )

+

PROTEIN_ASSOCIATION: ( H16_B1390 ) or ( H16_A0999 )

+

SUBSYSTEM: Glycolysis/Gluconeogenesis

+

PROTEIN_CLASS: 3.1.3.11

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2967 )

+

PROTEIN_ASSOCIATION: ( H16_A2967 )

+

SUBSYSTEM: Porphyrin and Chlorophyll metabolism

+

PROTEIN_CLASS: 2.7.8.26

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2780 ) or ( H16_B0984 ) or ( H16_A1098 ) or ( H16_A0784 )

+

PROTEIN_ASSOCIATION: ( H16_A2780 ) or ( H16_B0984 ) or ( H16_A1098 ) or ( H16_A0784 )

+

SUBSYSTEM: Cyanoamino acid metabolism

+

PROTEIN_CLASS: 2.3.2.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2780 ) or ( H16_B0984 ) or ( H16_A1098 ) or ( H16_A0784 )

+

PROTEIN_ASSOCIATION: ( H16_A2780 ) or ( H16_B0984 ) or ( H16_A1098 ) or ( H16_A0784 )

+

SUBSYSTEM: Cyanoamino acid metabolism

+

PROTEIN_CLASS: 2.3.2.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2280 ) or ( H16_A1910 )

+

PROTEIN_ASSOCIATION: ( H16_A2280 ) or ( H16_A1910 )

+

SUBSYSTEM: Glutamate metabolism

+

PROTEIN_CLASS: 3.5.1.38

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2280 ) or ( H16_A1910 )

+

PROTEIN_ASSOCIATION: ( H16_A2280 ) or ( H16_A1910 )

+

SUBSYSTEM: D-glutamate metabolism

+

PROTEIN_CLASS: 3.5.1.38

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0831 )

+

PROTEIN_ASSOCIATION: ( H16_A0831 )

+

SUBSYSTEM: Tyrosine metabolism

+

PROTEIN_CLASS: 1.4.3.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Lipopolysaccharide Biosynthesis / Recycling

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2931 )

+

PROTEIN_ASSOCIATION: ( H16_A2931 )

+

SUBSYSTEM: Pyrimidine metabolism

+

PROTEIN_CLASS: 3.5.4.13

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2931 )

+

PROTEIN_ASSOCIATION: ( H16_A2931 )

+

SUBSYSTEM: Pyrimidine metabolism

+

PROTEIN_CLASS: 3.5.4.13

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1404 )

+

PROTEIN_ASSOCIATION: ( H16_A1404 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 3.6.1.13

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3619 ) or ( H16_A1567 )

+

PROTEIN_ASSOCIATION: ( H16_A3619 ) or ( H16_A1567 )

+

SUBSYSTEM: One carbon pool by Folate

+

PROTEIN_CLASS: 2.1.2.10

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0362 )

+

PROTEIN_ASSOCIATION: ( H16_A0362 )

+

SUBSYSTEM: Tyrosine metabolism

+

PROTEIN_CLASS: 5.2.1.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0249 )

+

PROTEIN_ASSOCIATION: ( H16_A0249 )

+

SUBSYSTEM: One carbon pool by Folate

+

PROTEIN_CLASS: 6.3.3.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Ubiquinone Biosynthesis

+

PROTEIN_CLASS: 1.14.13.-

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3242 )

+

PROTEIN_ASSOCIATION: ( H16_A3242 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 2.4.2.8

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A1720 ) or ( H16_B0662 ) or ( H16_A1713 ) or ( H16_A0867 ) or ( H16_A0868 ) or ( H16_B0668 ) or ( H16_A0872 ) or ( H16_B0406 ) or ( H16_B1369 ) or ( H16_A0170 ) or ( H16_A1445 ) or ( H16_A1438 ) or ( H16_A2148 ) or ( H16_B0759 ) or ( H16_B0380 ) or ( H16_B0381 ) or ( H16_A1528 ) or ( H16_A1297 ) or ( H16_A1887 ) or ( H16_B1771 )

+

PROTEIN_ASSOCIATION: ( H16_A1720 ) or ( H16_B0662 ) or ( H16_A1713 ) or ( H16_A0867 ) or ( H16_A0868 ) or ( H16_B0668 ) or ( H16_A0872 ) or ( H16_B0406 ) or ( H16_B1369 ) or ( H16_A0170 ) or ( H16_A1445 ) or ( H16_A1438 ) or ( H16_A2148 ) or ( H16_B0759 ) or ( H16_B0380 ) or ( H16_B0381 ) or ( H16_A1528 ) or ( H16_A1297 ) or ( H16_A1887 ) or ( H16_B1771 )

+

SUBSYSTEM: Fatty acid biosynthesis

+

PROTEIN_CLASS: 2.3.1.9

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3009 )

+

PROTEIN_ASSOCIATION: ( H16_A3009 )

+

SUBSYSTEM: Cysteine Metabolism

+

PROTEIN_CLASS: 4.1.1.12

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Histidine Metabolism

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2993 )

+

PROTEIN_ASSOCIATION: ( H16_A2993 )

+

SUBSYSTEM: Porphyrin and Chlorophyll metabolism

+

PROTEIN_CLASS: 4.99.1.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A0479 )

+

PROTEIN_ASSOCIATION: ( H16_A0479 )

+

SUBSYSTEM: Pyrimidine metabolism

+

PROTEIN_CLASS: 3.5.2.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: gamma-Hexachlorocyclohexane degradation

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2546 )

+

PROTEIN_ASSOCIATION: ( H16_A2546 )

+

SUBSYSTEM: Glycerophospholipid Metabolism

+

PROTEIN_CLASS: 2.7.8.5

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0873 )

+

PROTEIN_ASSOCIATION: ( H16_B0873 )

+

SUBSYSTEM: Tyrosine metabolism

+

PROTEIN_CLASS: 1.13.11.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1363 )

+

PROTEIN_ASSOCIATION: ( H16_A1363 )

+

SUBSYSTEM: Atrazine degradation

+

PROTEIN_CLASS: 3.5.99.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0626 )

+

PROTEIN_ASSOCIATION: ( H16_B0626 )

+

SUBSYSTEM: Sulfur Metabolism

+

PROTEIN_CLASS: 2.7.1.25

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1134 )

+

PROTEIN_ASSOCIATION: ( H16_A1134 )

+

SUBSYSTEM: Porphyrin and Chlorophyll metabolism

+

PROTEIN_CLASS: 4.99.1.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1363 )

+

PROTEIN_ASSOCIATION: ( H16_A1363 )

+

SUBSYSTEM: Atrazine degradation

+

PROTEIN_CLASS: 3.5.99.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2816 ) or ( H16_B1418 )

+

PROTEIN_ASSOCIATION: ( H16_A2816 ) or ( H16_B1418 )

+

SUBSYSTEM: Tryptophan metabolism

+

PROTEIN_CLASS: 1.13.11.11

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0626 )

+

PROTEIN_ASSOCIATION: ( H16_B0626 )

+

SUBSYSTEM: Selenoamino acid metabolism

+

PROTEIN_CLASS: 2.7.1.25

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1888 ) or ( H16_B1652 ) or ( H16_A0602 ) or ( H16_B0388 ) or ( H16_B0724 ) or ( H16_A1102 ) or ( H16_A0282 )

+

PROTEIN_ASSOCIATION: ( H16_A1888 ) or ( H16_B1652 ) or ( H16_A0602 ) or ( H16_B0388 ) or ( H16_B0724 ) or ( H16_A1102 ) or ( H16_A0282 )

+

SUBSYSTEM: Membrane Lipid Metabolism

+

PROTEIN_CLASS: 1.1.1.35

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Peptidoglycan Biosynthesis

+

PROTEIN_CLASS: 2.3.2.10

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3084 )

+

PROTEIN_ASSOCIATION: ( H16_A3084 )

+

SUBSYSTEM: Pantothenate and CoA biosynthesis

+

PROTEIN_CLASS: 2.1.2.11

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0183 )

+

PROTEIN_ASSOCIATION: ( H16_A0183 )

+

SUBSYSTEM: Biotin Metabolism

+

PROTEIN_CLASS: 2.8.1.6

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1813 )

+

PROTEIN_ASSOCIATION: ( H16_B1813 )

+

SUBSYSTEM: Pentose Phosphate Pathway

+

PROTEIN_CLASS: 1.1.1.43

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0749 )

+

PROTEIN_ASSOCIATION: ( H16_A0749 )

+

SUBSYSTEM: Glutamate metabolism

+

PROTEIN_CLASS: 6.3.5.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3278 )

+

PROTEIN_ASSOCIATION: ( H16_A3278 )

+

SUBSYSTEM: Peptidoglycan Biosynthesis

+

PROTEIN_CLASS: 6.3.2.13

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2459 ) or ( H16_B1874 ) or ( H16_A1469 )

+

PROTEIN_ASSOCIATION: ( H16_B2459 ) or ( H16_B1874 ) or ( H16_A1469 )

+

SUBSYSTEM: Styrene degradation

+

PROTEIN_CLASS: 3.5.1.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2521 ) or ( H16_A1263 ) or ( H16_A0038 ) or ( H16_A0037 ) or ( H16_B1004 ) or ( H16_B2227 ) or ( H16_B0422 ) or ( H16_B1034 ) or ( H16_B1533 ) or ( H16_B2220 )

+

PROTEIN_ASSOCIATION: ( H16_B2521 ) or ( H16_A1263 ) or ( H16_A0038 ) or ( H16_A0037 ) or ( H16_B1004 ) or ( H16_B2227 ) or ( H16_B0422 ) or ( H16_B1034 ) or ( H16_B1533 ) or ( H16_B2220 )

+

SUBSYSTEM: Taurine and Hypotaurine metabolism

+

PROTEIN_CLASS: 1.14.11.17

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2459 ) or ( H16_B1874 ) or ( H16_A1469 )

+

PROTEIN_ASSOCIATION: ( H16_B2459 ) or ( H16_B1874 ) or ( H16_A1469 )

+

SUBSYSTEM: Benzoate degradation via CoA ligation

+

PROTEIN_CLASS: 3.5.1.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B1365 )

+

PROTEIN_ASSOCIATION: ( H16_B1365 )

+

SUBSYSTEM: Propanoate metabolism

+

PROTEIN_CLASS: 3.5.99.7

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2459 ) or ( H16_B1874 ) or ( H16_A1469 )

+

PROTEIN_ASSOCIATION: ( H16_B2459 ) or ( H16_B1874 ) or ( H16_A1469 )

+

SUBSYSTEM: Phenylalanine metabolism

+

PROTEIN_CLASS: 3.5.1.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2459 ) or ( H16_B1874 ) or ( H16_A1469 )

+

PROTEIN_ASSOCIATION: ( H16_B2459 ) or ( H16_B1874 ) or ( H16_A1469 )

+

SUBSYSTEM: Urea Cycle and Metabolism of amino groups

+

PROTEIN_CLASS: 3.5.1.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2447 )

+

PROTEIN_ASSOCIATION: ( H16_B2447 )

+

SUBSYSTEM: 1- and 2-Methylnaphthalene degradation

+

PROTEIN_CLASS: 4.1.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2459 ) or ( H16_B1874 ) or ( H16_A1469 )

+

PROTEIN_ASSOCIATION: ( H16_B2459 ) or ( H16_B1874 ) or ( H16_A1469 )

+

SUBSYSTEM: Tryptophan metabolism

+

PROTEIN_CLASS: 3.5.1.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0239 )

+

PROTEIN_ASSOCIATION: ( H16_A0239 )

+

SUBSYSTEM: Thiamine Metabolism

+

PROTEIN_CLASS: 2.5.1.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0757 ) or ( H16_B1109 ) or ( H16_B1420 ) or ( H16_B0223 ) or ( H16_B1836 ) or ( H16_A0633 )

+

PROTEIN_ASSOCIATION: ( H16_B0757 ) or ( H16_B1109 ) or ( H16_B1420 ) or ( H16_B0223 ) or ( H16_B1836 ) or ( H16_A0633 )

+

SUBSYSTEM: Naphthalene and Anthracene degradation

+

PROTEIN_CLASS: 1.13.11.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1888 ) or ( H16_B1652 ) or ( H16_A0602 ) or ( H16_B0388 ) or ( H16_B0724 ) or ( H16_A1102 ) or ( H16_A0282 )

+

PROTEIN_ASSOCIATION: ( H16_A1888 ) or ( H16_B1652 ) or ( H16_A0602 ) or ( H16_B0388 ) or ( H16_B0724 ) or ( H16_A1102 ) or ( H16_A0282 )

+

SUBSYSTEM: Fatty acid biosynthesis

+

PROTEIN_CLASS: 1.1.1.35

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A1888 ) or ( H16_B1652 ) or ( H16_A0602 ) or ( H16_B0388 ) or ( H16_B0724 ) or ( H16_A1102 ) or ( H16_A0282 )

+

PROTEIN_ASSOCIATION: ( H16_A1888 ) or ( H16_B1652 ) or ( H16_A0602 ) or ( H16_B0388 ) or ( H16_B0724 ) or ( H16_A1102 ) or ( H16_A0282 )

+

SUBSYSTEM: Membrane Lipid Metabolism

+

PROTEIN_CLASS: 1.1.1.35

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1888 ) or ( H16_B1652 ) or ( H16_A0602 ) or ( H16_B0388 ) or ( H16_B0724 ) or ( H16_A1102 ) or ( H16_A0282 )

+

PROTEIN_ASSOCIATION: ( H16_A1888 ) or ( H16_B1652 ) or ( H16_A0602 ) or ( H16_B0388 ) or ( H16_B0724 ) or ( H16_A1102 ) or ( H16_A0282 )

+

SUBSYSTEM: Membrane Lipid Metabolism

+

PROTEIN_CLASS: 1.1.1.35

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1102 )

+

PROTEIN_ASSOCIATION: ( H16_A1102 )

+

SUBSYSTEM: Benzoate degradation via CoA ligation

+

PROTEIN_CLASS: 1.1.1.157

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0315 )

+

PROTEIN_ASSOCIATION: ( H16_A0315 )

+

SUBSYSTEM: Aminosugars metabolism

+

PROTEIN_CLASS: 3.5.99.6

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B0283 ) or ( H16_B0226 )

+

PROTEIN_ASSOCIATION: ( H16_B0283 ) or ( H16_B0226 )

+

SUBSYSTEM: Nucleotide sugars metabolism

+

PROTEIN_CLASS: 5.1.3.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2012 )

+

PROTEIN_ASSOCIATION: ( H16_A2012 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 2.4.2.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Vitamine B6 metabolism

+

PROTEIN_CLASS: 2.6.1.54

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2012 )

+

PROTEIN_ASSOCIATION: ( H16_A2012 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 2.4.2.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2012 )

+

PROTEIN_ASSOCIATION: ( H16_A2012 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 2.4.2.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2012 )

+

PROTEIN_ASSOCIATION: ( H16_A2012 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 2.4.2.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3276 )

+

PROTEIN_ASSOCIATION: ( H16_A3276 )

+

SUBSYSTEM: Peptidoglycan Biosynthesis

+

PROTEIN_CLASS: 2.7.8.13

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A1334 ) or ( H16_A1814 )

+

PROTEIN_ASSOCIATION: ( H16_A1334 ) or ( H16_A1814 )

+

SUBSYSTEM: Butanoate metabolism

+

PROTEIN_CLASS: 1.1.1.30

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2012 )

+

PROTEIN_ASSOCIATION: ( H16_A2012 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 2.4.2.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2012 )

+

PROTEIN_ASSOCIATION: ( H16_A2012 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 2.4.2.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2012 )

+

PROTEIN_ASSOCIATION: ( H16_A2012 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 2.4.2.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2135 ) or ( H16_B0495 ) or ( H16_A1145 ) or ( H16_B1480 )

+

PROTEIN_ASSOCIATION: ( H16_B2135 ) or ( H16_B0495 ) or ( H16_A1145 ) or ( H16_B1480 )

+

SUBSYSTEM: Tyrosine metabolism

+

PROTEIN_CLASS: 1.14.13.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2135 ) or ( H16_B0495 ) or ( H16_A1145 ) or ( H16_B1480 )

+

PROTEIN_ASSOCIATION: ( H16_B2135 ) or ( H16_B0495 ) or ( H16_A1145 ) or ( H16_B1480 )

+

SUBSYSTEM: Histidine Metabolism

+

PROTEIN_CLASS: 1.14.13.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2848 )

+

PROTEIN_ASSOCIATION: ( H16_A2848 )

+

SUBSYSTEM: Rivoflavin metabolism

+

PROTEIN_CLASS: 3.5.4.26

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3082 )

+

PROTEIN_ASSOCIATION: ( H16_A3082 )

+

SUBSYSTEM: Folate Biosynthesis

+

PROTEIN_CLASS: 2.7.6.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Putative Transporters

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0136 )

+

PROTEIN_ASSOCIATION: ( H16_A0136 )

+

SUBSYSTEM: Pantothenate and CoA biosynthesis

+

PROTEIN_CLASS: 2.7.1.33

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1919 )

+

PROTEIN_ASSOCIATION: ( H16_A1919 )

+

SUBSYSTEM: Glyoxylate and Dicarboxylate metabolism

+

PROTEIN_CLASS: 1.2.1.21 1.2.1.22

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2454 ) or ( H16_A2452 ) or ( H16_A2106 )

+

PROTEIN_ASSOCIATION: ( H16_A2454 ) or ( H16_A2452 ) or ( H16_A2106 )

+

SUBSYSTEM: Glutamate metabolism

+

PROTEIN_CLASS: 6.3.5.5

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2135 ) or ( H16_B0495 ) or ( H16_A1145 ) or ( H16_B1480 )

+

PROTEIN_ASSOCIATION: ( H16_B2135 ) or ( H16_B0495 ) or ( H16_A1145 ) or ( H16_B1480 )

+

SUBSYSTEM: Toluene and Xylene degradation

+

PROTEIN_CLASS: 1.14.13.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0136 )

+

PROTEIN_ASSOCIATION: ( H16_A0136 )

+

SUBSYSTEM: Pantothenate and CoA biosynthesis

+

PROTEIN_CLASS: 2.7.1.33

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2135 ) or ( H16_B0495 ) or ( H16_A1145 ) or ( H16_B1480 )

+

PROTEIN_ASSOCIATION: ( H16_B2135 ) or ( H16_B0495 ) or ( H16_A1145 ) or ( H16_B1480 )

+

SUBSYSTEM: Tryptophan metabolism

+

PROTEIN_CLASS: 1.14.13.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0136 )

+

PROTEIN_ASSOCIATION: ( H16_A0136 )

+

SUBSYSTEM: Pantothenate and CoA biosynthesis

+

PROTEIN_CLASS: 2.7.1.33

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2135 ) or ( H16_B0495 ) or ( H16_A1145 ) or ( H16_B1480 )

+

PROTEIN_ASSOCIATION: ( H16_B2135 ) or ( H16_B0495 ) or ( H16_A1145 ) or ( H16_B1480 )

+

SUBSYSTEM: Tyrosine metabolism

+

PROTEIN_CLASS: 1.14.13.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2135 ) or ( H16_B0495 ) or ( H16_A1145 ) or ( H16_B1480 )

+

PROTEIN_ASSOCIATION: ( H16_B2135 ) or ( H16_B0495 ) or ( H16_A1145 ) or ( H16_B1480 )

+

SUBSYSTEM: gamma-Hexachlorocyclohexane degradation

+

PROTEIN_CLASS: 1.14.13.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2135 ) or ( H16_B0495 ) or ( H16_A1145 ) or ( H16_B1480 )

+

PROTEIN_ASSOCIATION: ( H16_B2135 ) or ( H16_B0495 ) or ( H16_A1145 ) or ( H16_B1480 )

+

SUBSYSTEM: gamma-Hexachlorocyclohexane degradation

+

PROTEIN_CLASS: 1.14.13.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3443 )

+

PROTEIN_ASSOCIATION: ( H16_A3443 )

+

SUBSYSTEM: Lysine Biosynthesis

+

PROTEIN_CLASS: 4.1.1.20

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2135 ) or ( H16_B0495 ) or ( H16_A1145 ) or ( H16_B1480 )

+

PROTEIN_ASSOCIATION: ( H16_B2135 ) or ( H16_B0495 ) or ( H16_A1145 ) or ( H16_B1480 )

+

SUBSYSTEM: Toluene and Xylene degradation

+

PROTEIN_CLASS: 1.14.13.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0262 )

+

PROTEIN_ASSOCIATION: ( H16_A0262 )

+

SUBSYSTEM: Aminosugars metabolism

+

PROTEIN_CLASS: 2.7.7.23

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2896 )

+

PROTEIN_ASSOCIATION: ( H16_A2896 )

+

SUBSYSTEM: Starch and sucrose metabolism

+

PROTEIN_CLASS: 4.2.1.45

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B2123 ) or ( H16_A0180 )

+

PROTEIN_ASSOCIATION: ( H16_B2123 ) or ( H16_A0180 )

+

SUBSYSTEM: Biotin Metabolism

+

PROTEIN_CLASS: 2.6.1.62

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2994 ) or ( H16_A2919 ) or ( H16_B2285 )

+

PROTEIN_ASSOCIATION: ( H16_A2994 ) or ( H16_A2919 ) or ( H16_B2285 )

+

SUBSYSTEM: Porphyrin and Chlorophyll metabolism

+

PROTEIN_CLASS: 2.1.1.107

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0508 ) or ( H16_A1505 ) or ( H16_A0770 ) or ( H16_A0817 ) or ( H16_B1893 )

+

PROTEIN_ASSOCIATION: ( H16_B0508 ) or ( H16_A1505 ) or ( H16_A0770 ) or ( H16_A0817 ) or ( H16_B1893 )

+

SUBSYSTEM: Phenylalanine metabolism

+

PROTEIN_CLASS: 1.4.99.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A0915 )

+

PROTEIN_ASSOCIATION: ( H16_A0915 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 6.3.4.13

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A1332 ) or ( H16_A1331 )

+

PROTEIN_ASSOCIATION: ( H16_A1332 ) or ( H16_A1331 )

+

SUBSYSTEM: Butanoate metabolism

+

PROTEIN_CLASS: 2.8.3.5

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0918 ) or ( H16_A2914 )

+

PROTEIN_ASSOCIATION: ( H16_A0918 ) or ( H16_A2914 )

+

SUBSYSTEM: Pyrimidine metabolism

+

PROTEIN_CLASS: 2.4.2.9

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3091 )

+

PROTEIN_ASSOCIATION: ( H16_A3091 )

+

SUBSYSTEM: Oxidative Phosphorylation

+

PROTEIN_CLASS: 1.1.2.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3711 )

+

PROTEIN_ASSOCIATION: ( H16_A3711 )

+

SUBSYSTEM: Anaplerotic Reactions

+

PROTEIN_CLASS: 4.1.1.32

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2857 )

+

PROTEIN_ASSOCIATION: ( H16_A2857 )

+

SUBSYSTEM: Cysteine Metabolism

+

PROTEIN_CLASS: 2.6.1.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0462 ) or ( H16_B0200 ) or ( H16_A1290 )

+

PROTEIN_ASSOCIATION: ( H16_A0462 ) or ( H16_B0200 ) or ( H16_A1290 )

+

SUBSYSTEM: Ethylbenzene degradation

+

PROTEIN_CLASS: 2.3.1.16

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2857 )

+

PROTEIN_ASSOCIATION: ( H16_A2857 )

+

SUBSYSTEM: Cysteine Metabolism

+

PROTEIN_CLASS: 2.6.1.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2857 )

+

PROTEIN_ASSOCIATION: ( H16_A2857 )

+

SUBSYSTEM: Cysteine Metabolism

+

PROTEIN_CLASS: 2.6.1.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2857 )

+

PROTEIN_ASSOCIATION: ( H16_A2857 )

+

SUBSYSTEM: Arginine and Proline metabolism

+

PROTEIN_CLASS: 2.6.1.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1241 )

+

PROTEIN_ASSOCIATION: ( H16_B1241 )

+

SUBSYSTEM: Trinitrotoluene degradation

+

PROTEIN_CLASS: 2.3.1.5

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2231 and H16_B0735 and H16_B0313 and H16_B2452 and H16_A1036 ) or ( H16_A1035 )

+

PROTEIN_ASSOCIATION: ( H16_A2231_and_H16_B0735_and_H16_B0313_and_H16_B2452_and_H16_A1036 ) or ( H16_A1035 )

+

SUBSYSTEM: Valine, Leucine, and Isoleucine Metabolism

+

PROTEIN_CLASS: 2.2.1.6

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1317 )

+

PROTEIN_ASSOCIATION: ( H16_A1317 )

+

SUBSYSTEM: Phenylalanine, Tyrosine and Tryptophan biosynthesis

+

PROTEIN_CLASS: 4.2.3.5

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0792 )

+

PROTEIN_ASSOCIATION: ( H16_A0792 )

+

SUBSYSTEM: Phenylalanine, Tyrosine and Tryptophan biosynthesis

+

PROTEIN_CLASS: 5.4.99.5

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Glycine, Serine and threonine Metabolism

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0862 )

+

PROTEIN_ASSOCIATION: ( H16_B0862 )

+

SUBSYSTEM: Atrazine degradation

+

PROTEIN_CLASS: 3.5.4.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0663 ) or ( H16_B0572 ) or ( H16_A1828 ) or ( H16_A1256 ) or ( H16_A0679 ) or ( H16_B2561 ) or ( H16_A0893 ) or ( H16_B0034 ) or ( H16_A2586 ) or ( H16_B1417 ) or ( H16_B0831 ) or ( H16_A2460 )

+

PROTEIN_ASSOCIATION: ( H16_B0663 ) or ( H16_B0572 ) or ( H16_A1828 ) or ( H16_A1256 ) or ( H16_A0679 ) or ( H16_B2561 ) or ( H16_A0893 ) or ( H16_B0034 ) or ( H16_A2586 ) or ( H16_B1417 ) or ( H16_B0831 ) or ( H16_A2460 )

+

SUBSYSTEM: Bisphenol A degradation

+

PROTEIN_CLASS: 1.1.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3170 ) or ( H16_B0465 )

+

PROTEIN_ASSOCIATION: ( H16_A3170 ) or ( H16_B0465 )

+

SUBSYSTEM: Phenylalanine, Tyrosine and Tryptophan biosynthesis

+

PROTEIN_CLASS: 4.2.1.10

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2030 )

+

PROTEIN_ASSOCIATION: ( H16_A2030 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 1.1.1.205

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0548 and H16_A0547 )

+

PROTEIN_ASSOCIATION: ( H16_A0548_and_H16_A0547 )

+

SUBSYSTEM: Citric Acid Cycle

+

PROTEIN_CLASS: 6.2.1.5

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1214 )

+

PROTEIN_ASSOCIATION: ( H16_A1214 )

+

SUBSYSTEM: Inositol Phosphate Metabolism

+

PROTEIN_CLASS: 3.1.3.25

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0874 ) or ( H16_B0428 )

+

PROTEIN_ASSOCIATION: ( H16_B0874 ) or ( H16_B0428 )

+

SUBSYSTEM: Tyrosine metabolism

+

PROTEIN_CLASS: 3.7.1.5

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1475 )

+

PROTEIN_ASSOCIATION: ( H16_A1475 )

+

SUBSYSTEM: Pyrimidine metabolism

+

PROTEIN_CLASS: 3.5.1.6

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1475 )

+

PROTEIN_ASSOCIATION: ( H16_A1475 )

+

SUBSYSTEM: Pyrimidine metabolism

+

PROTEIN_CLASS: 3.5.1.6

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A3186 )

+

PROTEIN_ASSOCIATION: ( H16_A3186 )

+

SUBSYSTEM: Galactose metabolism

+

PROTEIN_CLASS: 1.1.1.21

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B2057 ) or ( H16_B1537 ) or ( H16_B1179 ) or ( H16_B0982 )

+

PROTEIN_ASSOCIATION: ( H16_B2057 ) or ( H16_B1537 ) or ( H16_B1179 ) or ( H16_B0982 )

+

SUBSYSTEM: Alanine and Aspartate Metabolism

+

PROTEIN_CLASS: 1.2.1.16

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Purine and Pyrimidine Biosynthesis

+

PROTEIN_CLASS: 2.1.2.-

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0677 ) or ( H16_B2522 ) or ( H16_B1709 ) or ( H16_A1700 ) or ( H16_A2794 ) or ( H16_A2252 ) or ( H16_A2807 ) or ( H16_A1718 ) or ( H16_A0866 ) or ( H16_A0871 ) or ( H16_A1230 ) or ( H16_B0174 ) or ( H16_A1519 ) or ( H16_B1335 ) or ( H16_B0910 ) or ( H16_B1264 ) or ( H16_B1148 ) or ( H16_B1662 ) or ( H16_A2978 )

+

PROTEIN_ASSOCIATION: ( H16_B0677 ) or ( H16_B2522 ) or ( H16_B1709 ) or ( H16_A1700 ) or ( H16_A2794 ) or ( H16_A2252 ) or ( H16_A2807 ) or ( H16_A1718 ) or ( H16_A0866 ) or ( H16_A0871 ) or ( H16_A1230 ) or ( H16_B0174 ) or ( H16_A1519 ) or ( H16_B1335 ) or ( H16_B0910 ) or ( H16_B1264 ) or ( H16_B1148 ) or ( H16_B1662 ) or ( H16_A2978 )

+

SUBSYSTEM: Benzoate degradation via CoA ligation

+

PROTEIN_CLASS: 6.2.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0862 )

+

PROTEIN_ASSOCIATION: ( H16_B0862 )

+

SUBSYSTEM: Atrazine degradation

+

PROTEIN_CLASS: 3.5.4.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2149 ) or ( H16_B0675 ) or ( H16_A2808 ) or ( H16_B0699 ) or ( H16_A2143 )

+

PROTEIN_ASSOCIATION: ( H16_A2149 ) or ( H16_B0675 ) or ( H16_A2808 ) or ( H16_B0699 ) or ( H16_A2143 )

+

SUBSYSTEM: 1- and 2-Methylnaphthalene degradation

+

PROTEIN_CLASS: 1.3.99.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Butanoate metabolism

+

PROTEIN_CLASS: 6.2.1.2

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A3263 )

+

PROTEIN_ASSOCIATION: ( H16_A3263 )

+

SUBSYSTEM: Urea Cycle and Metabolism of amino groups

+

PROTEIN_CLASS: 2.3.1.35

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A3186 )

+

PROTEIN_ASSOCIATION: ( H16_A3186 )

+

SUBSYSTEM: Pentose and glucuronate interconversion

+

PROTEIN_CLASS: 1.1.1.21

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Putative Transporters

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1113 )

+

PROTEIN_ASSOCIATION: ( H16_A1113 )

+

SUBSYSTEM: Toluene and Xylene degradation

+

PROTEIN_CLASS: 4.1.1.7

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2815 )

+

PROTEIN_ASSOCIATION: ( H16_A2815 )

+

SUBSYSTEM: Tryptophan metabolism

+

PROTEIN_CLASS: 3.7.1.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1113 )

+

PROTEIN_ASSOCIATION: ( H16_A1113 )

+

SUBSYSTEM: Benzoate degradation via Hydroxylation

+

PROTEIN_CLASS: 4.1.1.7

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2815 )

+

PROTEIN_ASSOCIATION: ( H16_A2815 )

+

SUBSYSTEM: Tryptophan metabolism

+

PROTEIN_CLASS: 3.7.1.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A3186 )

+

PROTEIN_ASSOCIATION: ( H16_A3186 )

+

SUBSYSTEM: Pentose and glucuronate interconversion

+

PROTEIN_CLASS: 1.1.1.21

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A3186 )

+

PROTEIN_ASSOCIATION: ( H16_A3186 )

+

SUBSYSTEM: Fructose and Mannose metabolism

+

PROTEIN_CLASS: 1.1.1.21

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2815 )

+

PROTEIN_ASSOCIATION: ( H16_A2815 )

+

SUBSYSTEM: Tryptophan metabolism

+

PROTEIN_CLASS: 3.7.1.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1238 )

+

PROTEIN_ASSOCIATION: ( H16_B1238 )

+

SUBSYSTEM: gamma-Hexachlorocyclohexane degradation

+

PROTEIN_CLASS: 3.1.3.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1616 ) or ( H16_B0834 ) or ( H16_A2525 ) or ( H16_B1102 ) or ( H16_B0696 ) or ( H16_B0386 ) or ( H16_B0591 )

+

PROTEIN_ASSOCIATION: ( H16_A1616 ) or ( H16_B0834 ) or ( H16_A2525 ) or ( H16_B1102 ) or ( H16_B0696 ) or ( H16_B0386 ) or ( H16_B0591 )

+

SUBSYSTEM: Pyruvate Metabolism

+

PROTEIN_CLASS: 6.2.1.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B0103 ) or ( H16_A2528 )

+

PROTEIN_ASSOCIATION: ( H16_B0103 ) or ( H16_A2528 )

+

SUBSYSTEM: Citric Acid Cycle

+

PROTEIN_CLASS: 4.2.1.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0847 ) or ( H16_B0367 ) or ( H16_B0655 ) or ( H16_B0656 ) or ( H16_B0914 ) or ( H16_B0355 ) or ( H16_B0488 )

+

PROTEIN_ASSOCIATION: ( H16_B0847 ) or ( H16_B0367 ) or ( H16_B0655 ) or ( H16_B0656 ) or ( H16_B0914 ) or ( H16_B0355 ) or ( H16_B0488 )

+

SUBSYSTEM: Geraniol degrdation

+

PROTEIN_CLASS: 2.8.3.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1051 ) or ( H16_A1052 ) or ( H16_A1050 ) or ( H16_A1055 ) or ( H16_A1056 ) or ( H16_A1053 ) or ( H16_A1054 ) or ( H16_A1061 ) or ( H16_A1060 ) or ( H16_A1063 ) or ( H16_A1062 ) or ( H16_A1059 ) or ( H16_A1058 ) or ( H16_A1057 ) or ( H16_A0251 )

+

PROTEIN_ASSOCIATION: ( H16_A1051 ) or ( H16_A1052 ) or ( H16_A1050 ) or ( H16_A1055 ) or ( H16_A1056 ) or ( H16_A1053 ) or ( H16_A1054 ) or ( H16_A1061 ) or ( H16_A1060 ) or ( H16_A1063 ) or ( H16_A1062 ) or ( H16_A1059 ) or ( H16_A1058 ) or ( H16_A1057 ) or ( H16_A0251 )

+

SUBSYSTEM: Ubiquinone

+

PROTEIN_CLASS: 1.6.5.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0757 ) or ( H16_B1109 ) or ( H16_B1420 ) or ( H16_B0223 ) or ( H16_B1836 ) or ( H16_A0633 )

+

PROTEIN_ASSOCIATION: ( H16_B0757 ) or ( H16_B1109 ) or ( H16_B1420 ) or ( H16_B0223 ) or ( H16_B1836 ) or ( H16_A0633 )

+

SUBSYSTEM: Benzoate degradation via Hydroxylation

+

PROTEIN_CLASS: 1.13.11.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3048 )

+

PROTEIN_ASSOCIATION: ( H16_A3048 )

+

SUBSYSTEM: Pantothenate and CoA biosynthesis

+

PROTEIN_CLASS: 6.3.2.5

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0515 )

+

PROTEIN_ASSOCIATION: ( H16_A0515 )

+

SUBSYSTEM: Aminoacyl-tRNA Biosynthesi

+

PROTEIN_CLASS: 6.1.1.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A0734 )

+

PROTEIN_ASSOCIATION: ( H16_A0734 )

+

SUBSYSTEM: Porphyrin and Chlorophyll metabolism

+

PROTEIN_CLASS: 5.4.3.8

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3631 )

+

PROTEIN_ASSOCIATION: ( H16_A3631 )

+

SUBSYSTEM: Arginine and Proline Metabolism

+

PROTEIN_CLASS: 1.5.99.8

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3129 )

+

PROTEIN_ASSOCIATION: ( H16_A3129 )

+

SUBSYSTEM: Alanine and Aspartate Metabolism

+

PROTEIN_CLASS: 4.1.1.11

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0831 )

+

PROTEIN_ASSOCIATION: ( H16_A0831 )

+

SUBSYSTEM: Tryptophan metabolism

+

PROTEIN_CLASS: 1.4.3.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2961 )

+

PROTEIN_ASSOCIATION: ( H16_A2961 )

+

SUBSYSTEM: Porphyrin and Chlorophyll metabolism

+

PROTEIN_CLASS: 6.3.5.10

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0831 )

+

PROTEIN_ASSOCIATION: ( H16_A0831 )

+

SUBSYSTEM: Urea Cycle and Metabolism of amino groups

+

PROTEIN_CLASS: 1.4.3.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0831 )

+

PROTEIN_ASSOCIATION: ( H16_A0831 )

+

SUBSYSTEM: Tryptophan metabolism

+

PROTEIN_CLASS: 1.4.3.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0831 )

+

PROTEIN_ASSOCIATION: ( H16_A0831 )

+

SUBSYSTEM: Tryptophan metabolism

+

PROTEIN_CLASS: 1.4.3.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0831 )

+

PROTEIN_ASSOCIATION: ( H16_A0831 )

+

SUBSYSTEM: Tryptophan metabolism

+

PROTEIN_CLASS: 1.4.3.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1221 )

+

PROTEIN_ASSOCIATION: ( H16_A1221 )

+

SUBSYSTEM: Aminoacyl-tRNA Biosynthesi

+

PROTEIN_CLASS: 6.1.1.16

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1817 ) or ( H16_B0460 )

+

PROTEIN_ASSOCIATION: ( H16_B1817 ) or ( H16_B0460 )

+

SUBSYSTEM: Oxidative Phosphorylation

+

PROTEIN_CLASS: 1.1.2.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2043 )

+

PROTEIN_ASSOCIATION: ( H16_A2043 )

+

SUBSYSTEM: Lipopolysaccharide Biosynthesis

+

PROTEIN_CLASS: 2.3.1.129

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0539 and H16_B0540 and H16_B0541 and H16_B0542 and H16_B0543 and H16_B0544 )

+

PROTEIN_ASSOCIATION: ( H16_B0539_and_H16_B0540_and_H16_B0541_and_H16_B0542_and_H16_B0543_and_H16_B0544 )

+

SUBSYSTEM: Toluene and Xylene degradation

+

PROTEIN_CLASS: 1.14.13.7

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2818 )

+

PROTEIN_ASSOCIATION: ( H16_A2818 )

+

SUBSYSTEM: Lysine degradation

+

PROTEIN_CLASS: 1.3.99.7

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2818 )

+

PROTEIN_ASSOCIATION: ( H16_A2818 )

+

SUBSYSTEM: Benzoate degradation via CoA ligation

+

PROTEIN_CLASS: 1.3.99.7

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2636 ) or ( H16_A1906 )

+

PROTEIN_ASSOCIATION: ( H16_A2636 ) or ( H16_A1906 )

+

SUBSYSTEM: Propanoate metabolism

+

PROTEIN_CLASS: 2.3.3.5

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0539 and H16_B0540 and H16_B0541 and H16_B0542 and H16_B0543 and H16_B0544 )

+

PROTEIN_ASSOCIATION: ( H16_B0539_and_H16_B0540_and_H16_B0541_and_H16_B0542_and_H16_B0543_and_H16_B0544 )

+

SUBSYSTEM: Toluene and Xylene degradation

+

PROTEIN_CLASS: 1.14.13.7

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0539 and H16_B0540 and H16_B0541 and H16_B0542 and H16_B0543 and H16_B0544 )

+

PROTEIN_ASSOCIATION: ( H16_B0539_and_H16_B0540_and_H16_B0541_and_H16_B0542_and_H16_B0543_and_H16_B0544 )

+

SUBSYSTEM: Toluene and Xylene degradation

+

PROTEIN_CLASS: 1.14.13.7

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1813 )

+

PROTEIN_ASSOCIATION: ( H16_B1813 )

+

SUBSYSTEM: Pentose Phosphate Pathway

+

PROTEIN_CLASS: 1.1.1.43

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0914 )

+

PROTEIN_ASSOCIATION: ( H16_A0914 )

+

SUBSYSTEM: Porphyrin and Chlorophyll metabolism

+

PROTEIN_CLASS: 1.3.3.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2368 )

+

PROTEIN_ASSOCIATION: ( H16_A2368 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 2.7.4.6

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2368 )

+

PROTEIN_ASSOCIATION: ( H16_A2368 )

+

SUBSYSTEM: Pyrimidine metabolism

+

PROTEIN_CLASS: 2.7.4.6

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2368 )

+

PROTEIN_ASSOCIATION: ( H16_A2368 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 2.7.4.6

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2368 )

+

PROTEIN_ASSOCIATION: ( H16_A2368 )

+

SUBSYSTEM: Pyrimidine metabolism

+

PROTEIN_CLASS: 2.7.4.6

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2368 )

+

PROTEIN_ASSOCIATION: ( H16_A2368 )

+

SUBSYSTEM: Pyrimidine metabolism

+

PROTEIN_CLASS: 2.7.4.6

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2368 )

+

PROTEIN_ASSOCIATION: ( H16_A2368 )

+

SUBSYSTEM: Pyrimidine metabolism

+

PROTEIN_CLASS: 2.7.4.6

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2368 )

+

PROTEIN_ASSOCIATION: ( H16_A2368 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 2.7.4.6

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2857 )

+

PROTEIN_ASSOCIATION: ( H16_A2857 )

+

SUBSYSTEM: Alanine and Aspartate Metabolism

+

PROTEIN_CLASS: 2.6.1.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2368 )

+

PROTEIN_ASSOCIATION: ( H16_A2368 )

+

SUBSYSTEM: Pyrimidine metabolism

+

PROTEIN_CLASS: 2.7.4.6

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2368 )

+

PROTEIN_ASSOCIATION: ( H16_A2368 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 2.7.4.6

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3249 )

+

PROTEIN_ASSOCIATION: ( H16_A3249 )

+

SUBSYSTEM: Urea Cycle and Metabolism of amino groups

+

PROTEIN_CLASS: 2.7.2.11

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1758 ) or ( H16_A0125 )

+

PROTEIN_ASSOCIATION: ( H16_B1758 ) or ( H16_A0125 )

+

SUBSYSTEM: Urea Cycle and Metabolism of amino groups

+

PROTEIN_CLASS: 3.5.1.54

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A1216 )

+

PROTEIN_ASSOCIATION: ( H16_A1216 )

+

SUBSYSTEM: Cysteine Metabolism

+

PROTEIN_CLASS: 2.3.1.30

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B1881 ) or ( H16_A0689 ) or ( H16_A3673 ) or ( H16_A1394 )

+

PROTEIN_ASSOCIATION: ( H16_B1881 ) or ( H16_A0689 ) or ( H16_A3673 ) or ( H16_A1394 )

+

SUBSYSTEM: Arginine and Proline Metabolism

+

PROTEIN_CLASS: 4.3.1.12

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1695 )

+

PROTEIN_ASSOCIATION: ( H16_B1695 )

+

SUBSYSTEM: Ubiquinone Biosynthesis

+

PROTEIN_CLASS: 4.1.3.36

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3094 ) or ( H16_A3097 ) or ( H16_A3096 )

+

PROTEIN_ASSOCIATION: ( H16_A3094 ) or ( H16_A3097 ) or ( H16_A3096 )

+

SUBSYSTEM: Glyoxylate and Dicarboxylate metabolism

+

PROTEIN_CLASS: 1.1.3.15

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2069 )

+

PROTEIN_ASSOCIATION: ( H16_A2069 )

+

SUBSYSTEM: Lysine Biosynthesis

+

PROTEIN_CLASS: 3.5.1.18

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2751 )

+

PROTEIN_ASSOCIATION: ( H16_A2751 )

+

SUBSYSTEM: Aminoacyl-tRNA Biosynthesi

+

PROTEIN_CLASS: 6.1.1.9

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3622 )

+

PROTEIN_ASSOCIATION: ( H16_A3622 )

+

SUBSYSTEM: Cysteine Metabolism

+

PROTEIN_CLASS: 4.3.1.17

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3283 )

+

PROTEIN_ASSOCIATION: ( H16_A3283 )

+

SUBSYSTEM: Ubiquinone Biosynthesis

+

PROTEIN_CLASS: 1.14.13.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

PROTEIN_CLASS: 2.7.7.6

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3048 )

+

PROTEIN_ASSOCIATION: ( H16_A3048 )

+

SUBSYSTEM: Pantothenate and CoA biosynthesis

+

PROTEIN_CLASS: 4.1.1.36

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2003 ) or ( H16_A1437 )

+

PROTEIN_ASSOCIATION: ( H16_A2003 ) or ( H16_A1437 )

+

SUBSYSTEM: Butanoate metabolism

+

PROTEIN_CLASS: 2.3.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0204 and H16_A2632 and H16_A2631 and H16_A2630 and H16_A2629 )

+

PROTEIN_ASSOCIATION: ( H16_B0204_and_H16_A2632_and_H16_A2631_and_H16_A2630_and_H16_A2629 )

+

SUBSYSTEM: Citric Acid Cycle

+

PROTEIN_CLASS: 1.3.99.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0757 ) or ( H16_B1109 ) or ( H16_B1420 ) or ( H16_B0223 ) or ( H16_B1836 ) or ( H16_A0633 )

+

PROTEIN_ASSOCIATION: ( H16_B0757 ) or ( H16_B1109 ) or ( H16_B1420 ) or ( H16_B0223 ) or ( H16_B1836 ) or ( H16_A0633 )

+

SUBSYSTEM: Fluorene degradation

+

PROTEIN_CLASS: 1.13.11.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0204 and H16_A2632 and H16_A2631 and H16_A2630 and H16_A2629 )

+

PROTEIN_ASSOCIATION: ( H16_B0204_and_H16_A2632_and_H16_A2631_and_H16_A2630_and_H16_A2629 )

+

SUBSYSTEM: Oxidative Phosphorylation

+

PROTEIN_CLASS: 1.3.99.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0324 )

+

PROTEIN_ASSOCIATION: ( H16_A0324 )

+

SUBSYSTEM: Transport, Inner Membrane

+

PROTEIN_CLASS: 2.7.1.69

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Oxidative Phosphorylation

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1693 )

+

PROTEIN_ASSOCIATION: ( H16_B1693 )

+

SUBSYSTEM: Benzoate degradation via CoA ligation

+

PROTEIN_CLASS: 6.2.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2802 )

+

PROTEIN_ASSOCIATION: ( H16_A2802 )

+

SUBSYSTEM: Vitamine B6 metabolism

+

PROTEIN_CLASS: 1.4.3.5

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Pyrimidine metabolism

+

PROTEIN_CLASS: 6.3.4.2

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3418 )

+

PROTEIN_ASSOCIATION: ( H16_A3418 )

+

SUBSYSTEM: Aminosugars metabolism

+

PROTEIN_CLASS: 2.5.1.7

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1339 )

+

PROTEIN_ASSOCIATION: ( H16_A1339 )

+

SUBSYSTEM: Aminoacyl-tRNA Biosynthesi

+

PROTEIN_CLASS: 6.1.1.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1631 ) or ( H16_B1871 )

+

PROTEIN_ASSOCIATION: ( H16_B1631 ) or ( H16_B1871 )

+

SUBSYSTEM: Propanoate metabolism

+

PROTEIN_CLASS: 2.3.1.8

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Oxidative Phosphorylation

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2905 ) or ( H16_A1854 )

+

PROTEIN_ASSOCIATION: ( H16_A2905 ) or ( H16_A1854 )

+

SUBSYSTEM: Fructose and Mannose metabolism

+

PROTEIN_CLASS: 2.7.7.22

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B1657 ) or ( H16_A1239 ) or ( H16_B1190 ) or ( H16_A1562 ) or ( H16_B1750 )

+

PROTEIN_ASSOCIATION: ( H16_B1657 ) or ( H16_A1239 ) or ( H16_B1190 ) or ( H16_A1562 ) or ( H16_B1750 )

+

SUBSYSTEM: Valine, Leucine and Isoleucine degradation

+

PROTEIN_CLASS: 1.1.1.31

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2135 ) or ( H16_B0495 ) or ( H16_A1145 ) or ( H16_B1480 )

+

PROTEIN_ASSOCIATION: ( H16_B2135 ) or ( H16_B0495 ) or ( H16_A1145 ) or ( H16_B1480 )

+

SUBSYSTEM: Bisphenol A degradation

+

PROTEIN_CLASS: 1.14.13.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2135 ) or ( H16_B0495 ) or ( H16_A1145 ) or ( H16_B1480 )

+

PROTEIN_ASSOCIATION: ( H16_B2135 ) or ( H16_B0495 ) or ( H16_A1145 ) or ( H16_B1480 )

+

SUBSYSTEM: Bisphenol A degradation

+

PROTEIN_CLASS: 1.14.13.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Tryptophan metabolism

+

PROTEIN_CLASS: 4.1.99.1

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2066 )

+

PROTEIN_ASSOCIATION: ( H16_A2066 )

+

SUBSYSTEM: Lysine Biosynthesis

+

PROTEIN_CLASS: 2.3.1.117

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1259 ) or ( H16_A1258 ) or ( H16_B0965 )

+

PROTEIN_ASSOCIATION: ( H16_A1259 ) or ( H16_A1258 ) or ( H16_B0965 )

+

SUBSYSTEM: Ascorbate and Aldarate metabolism

+

PROTEIN_CLASS: 4.2.1.42

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2733 )

+

PROTEIN_ASSOCIATION: ( H16_A2733 )

+

SUBSYSTEM: Biosynthesis of steroids

+

PROTEIN_CLASS: 2.5.1.10

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2802 )

+

PROTEIN_ASSOCIATION: ( H16_A2802 )

+

SUBSYSTEM: Vitamine B6 metabolism

+

PROTEIN_CLASS: 1.4.3.5

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0197 )

+

PROTEIN_ASSOCIATION: ( H16_A0197 )

+

SUBSYSTEM: gamma-Hexachlorocyclohexane degradation

+

PROTEIN_CLASS: 3.8.1.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1848 ) or ( H16_A2906 )

+

PROTEIN_ASSOCIATION: ( H16_A1848 ) or ( H16_A2906 )

+

SUBSYSTEM: Nucleotide sugars metabolism

+

PROTEIN_CLASS: 5.1.3.13

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3234 and H16_A3235 ) or ( H16_A2390 )

+

PROTEIN_ASSOCIATION: ( H16_A3234_and_H16_A3235 ) or ( H16_A2390 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 1.17.4.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3234 and H16_A3235 ) or ( H16_A2390 )

+

PROTEIN_ASSOCIATION: ( H16_A3234_and_H16_A3235 ) or ( H16_A2390 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 1.17.4.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A1251 ) or ( H16_A2142 )

+

PROTEIN_ASSOCIATION: ( H16_A1251 ) or ( H16_A2142 )

+

SUBSYSTEM: Pyruvate Metabolism

+

PROTEIN_CLASS: 6.4.1.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3234 and H16_A3235 ) or ( H16_A2390 )

+

PROTEIN_ASSOCIATION: ( H16_A3234_and_H16_A3235 ) or ( H16_A2390 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 1.17.4.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A0561 )

+

PROTEIN_ASSOCIATION: ( H16_A0561 )

+

SUBSYSTEM: Valine, Leucine, and Isoleucine Metabolism

+

PROTEIN_CLASS: 2.6.1.42

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3234 and H16_A3235 ) or ( H16_A2390 )

+

PROTEIN_ASSOCIATION: ( H16_A3234_and_H16_A3235 ) or ( H16_A2390 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 1.17.4.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0263 )

+

PROTEIN_ASSOCIATION: ( H16_A0263 )

+

SUBSYSTEM: Aminosugars metabolism

+

PROTEIN_CLASS: 2.6.1.16

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1656 )

+

PROTEIN_ASSOCIATION: ( H16_A1656 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 2.7.7.53

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1125 )

+

PROTEIN_ASSOCIATION: ( H16_A1125 )

+

SUBSYSTEM: Cyanoamino acid metabolism

+

PROTEIN_CLASS: 3.5.5.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1656 )

+

PROTEIN_ASSOCIATION: ( H16_A1656 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 2.7.7.53

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1125 )

+

PROTEIN_ASSOCIATION: ( H16_A1125 )

+

SUBSYSTEM: Cyanoamino acid metabolism

+

PROTEIN_CLASS: 3.5.5.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2752 )

+

PROTEIN_ASSOCIATION: ( H16_A2752 )

+

SUBSYSTEM: Nucleotide sugars metabolism

+

PROTEIN_CLASS: 2.7.7.9

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1125 )

+

PROTEIN_ASSOCIATION: ( H16_A1125 )

+

SUBSYSTEM: Tryptophan metabolism

+

PROTEIN_CLASS: 3.5.5.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3700 )

+

PROTEIN_ASSOCIATION: ( H16_A3700 )

+

SUBSYSTEM: Glyoxylate and Dicarboxylate metabolism

+

PROTEIN_CLASS: 3.5.1.31

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1125 )

+

PROTEIN_ASSOCIATION: ( H16_A1125 )

+

SUBSYSTEM: Benzoate degradation via CoA ligation

+

PROTEIN_CLASS: 3.5.5.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Toluene and Xylene degradation

+

PROTEIN_CLASS: 1.17.99.1

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1125 )

+

PROTEIN_ASSOCIATION: ( H16_A1125 )

+

SUBSYSTEM: Styrene degradation

+

PROTEIN_CLASS: 3.5.5.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1973 ) or ( H16_A0177 ) or ( H16_A2144 )

+

PROTEIN_ASSOCIATION: ( H16_A1973 ) or ( H16_A0177 ) or ( H16_A2144 )

+

SUBSYSTEM: Propanoate metabolism

+

PROTEIN_CLASS: 6.4.1.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Anaplerotic Reactions

+

PROTEIN_CLASS: 3.6.1.25

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0539 and H16_B0540 and H16_B0541 and H16_B0542 and H16_B0543 and H16_B0544 )

+

PROTEIN_ASSOCIATION: ( H16_B0539_and_H16_B0540_and_H16_B0541_and_H16_B0542_and_H16_B0543_and_H16_B0544 )

+

SUBSYSTEM: gamma-Hexachlorocyclohexane degradation

+

PROTEIN_CLASS: 1.14.13.7

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0746 )

+

PROTEIN_ASSOCIATION: ( H16_A0746 )

+

SUBSYSTEM: Anaplerotic Reactions

+

PROTEIN_CLASS: 3.6.1.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0539 and H16_B0540 and H16_B0541 and H16_B0542 and H16_B0543 and H16_B0544 )

+

PROTEIN_ASSOCIATION: ( H16_B0539_and_H16_B0540_and_H16_B0541_and_H16_B0542_and_H16_B0543_and_H16_B0544 )

+

SUBSYSTEM: Naphthalene and Anthracene degradation

+

PROTEIN_CLASS: 1.14.13.7

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2345 )

+

PROTEIN_ASSOCIATION: ( H16_A2345 )

+

SUBSYSTEM: Pentose Phosphate Pathway

+

PROTEIN_CLASS: 5.3.1.6

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Putative Transporters

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0961 ) or ( H16_A0567 ) or ( H16_A3602 )

+

PROTEIN_ASSOCIATION: ( H16_B0961 ) or ( H16_A0567 ) or ( H16_A3602 )

+

SUBSYSTEM: Glycolysis/Gluconeogenesis

+

PROTEIN_CLASS: 2.7.1.40

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3015 )

+

PROTEIN_ASSOCIATION: ( H16_A3015 )

+

SUBSYSTEM: Histidine Metabolism

+

PROTEIN_CLASS: 3.5.2.7

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B1391 ) or ( H16_A3317 )

+

PROTEIN_ASSOCIATION: ( H16_B1391 ) or ( H16_A3317 )

+

SUBSYSTEM: Pentose Phosphate Pathway

+

PROTEIN_CLASS: 5.1.3.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1081 ) or ( H16_A1151 )

+

PROTEIN_ASSOCIATION: ( H16_B1081 ) or ( H16_A1151 )

+

SUBSYSTEM: Phenylalanine, Tyrosine and Tryptophan biosynthesis

+

PROTEIN_CLASS: 2.6.1.57

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Fatty acid biosynthesis

+

PROTEIN_CLASS: 2.3.1.41 2.3.1.179 2.3.1.180 1.1.1.100

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Phenylalanine metabolism

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Fatty acid biosynthesis

+

PROTEIN_CLASS: 2.3.1.41 2.3.1.179 2.3.1.180 1.1.1.100

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1882 and H16_A1509 and H16_A0111 and H16_A0112 and H16_A0108 )

+

PROTEIN_ASSOCIATION: ( H16_A1882_and_H16_A1509_and_H16_A0111_and_H16_A0112_and_H16_A0108 )

+

SUBSYSTEM: Alanine and Aspartate Metabolism

+

PROTEIN_CLASS: 6.3.5.6

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0372 and H16_B0371 )

+

PROTEIN_ASSOCIATION: ( H16_B0372_and_H16_B0371 )

+

SUBSYSTEM: Benzoate degradation via CoA ligation

+

PROTEIN_CLASS: 1.3.1.62

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1882 and H16_A1509 and H16_A0111 and H16_A0112 and H16_A0108 )

+

PROTEIN_ASSOCIATION: ( H16_A1882_and_H16_A1509_and_H16_A0111_and_H16_A0112_and_H16_A0108 )

+

SUBSYSTEM: Glutamate metabolism

+

PROTEIN_CLASS: 6.3.5.7

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1199 ) or ( H16_A0753 ) or ( H16_B1422 ) or ( H16_B1092 ) or ( H16_A2592 ) or ( H16_A1779 )

+

PROTEIN_ASSOCIATION: ( H16_A1199 ) or ( H16_A0753 ) or ( H16_B1422 ) or ( H16_B1092 ) or ( H16_A2592 ) or ( H16_A1779 )

+

SUBSYSTEM: Oxidative Phosphorylation

+

PROTEIN_CLASS: 1.8.1.9

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2231 and H16_B0735 and H16_B0313 and H16_B2452 and H16_A1036 ) or ( H16_A1035 )

+

PROTEIN_ASSOCIATION: ( H16_A2231_and_H16_B0735_and_H16_B0313_and_H16_B2452_and_H16_A1036 ) or ( H16_A1035 )

+

SUBSYSTEM: Valine, Leucine, and Isoleucine Metabolism

+

PROTEIN_CLASS: 2.2.1.6

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0803 )

+

PROTEIN_ASSOCIATION: ( H16_A0803 )

+

SUBSYSTEM: Lipopolysaccharide Biosynthesis

+

PROTEIN_CLASS: 2.7.-.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Putative Transporters

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A1907 )

+

PROTEIN_ASSOCIATION: ( H16_A1907 )

+

SUBSYSTEM: Propanoate metabolism

+

PROTEIN_CLASS: 4.2.1.99

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0198 ) or ( H16_B0199 )

+

PROTEIN_ASSOCIATION: ( H16_B0198 ) or ( H16_B0199 )

+

SUBSYSTEM: Benzoate degradation via Hydroxylation

+

PROTEIN_CLASS: 2.8.3.6

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2096 )

+

PROTEIN_ASSOCIATION: ( H16_B2096 )

+

SUBSYSTEM: Starch and sucrose metabolism

+

PROTEIN_CLASS: 3.2.1.28

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Glycerophospholipid Metabolism

+

PROTEIN_CLASS: 2.7.8.1

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1967 )

+

PROTEIN_ASSOCIATION: ( H16_B1967 )

+

SUBSYSTEM: Folate Biosynthesis

+

PROTEIN_CLASS: 3.5.4.16

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3014 )

+

PROTEIN_ASSOCIATION: ( H16_A3014 )

+

SUBSYSTEM: Histidine Metabolism

+

PROTEIN_CLASS: 3.5.3.13

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3337 )

+

PROTEIN_ASSOCIATION: ( H16_A3337 )

+

SUBSYSTEM: Methionine Metabolism

+

PROTEIN_CLASS: 3.2.2.9

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1017 ) or ( H16_B1897 ) or ( H16_B1898 ) or ( H16_A3371 ) or ( H16_A1016 )

+

PROTEIN_ASSOCIATION: ( H16_A1017 ) or ( H16_B1897 ) or ( H16_B1898 ) or ( H16_A3371 ) or ( H16_A1016 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 1.17.1.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3277 )

+

PROTEIN_ASSOCIATION: ( H16_A3277 )

+

SUBSYSTEM: Peptidoglycan Biosynthesis

+

PROTEIN_CLASS: 6.3.2.10

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0445 )

+

PROTEIN_ASSOCIATION: ( H16_A0445 )

+

SUBSYSTEM: Ubiquinone Biosynthesis

+

PROTEIN_CLASS: 2.1.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B2460 )

+

PROTEIN_ASSOCIATION: ( H16_B2460 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 3.5.3.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Fatty acid biosynthesis

+

PROTEIN_CLASS: 2.3.1.41 2.3.1.179 2.3.1.180 1.1.1.100

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Fatty acid biosynthesis

+

PROTEIN_CLASS: 2.3.1.41 2.3.1.179 2.3.1.180 1.1.1.100

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1051 ) or ( H16_A1052 ) or ( H16_A1050 ) or ( H16_A1055 ) or ( H16_A1056 ) or ( H16_A1053 ) or ( H16_A1054 ) or ( H16_A1061 ) or ( H16_A1060 ) or ( H16_A1063 ) or ( H16_A1062 ) or ( H16_A1059 ) or ( H16_A1058 ) or ( H16_A1057 ) or ( H16_A0251 )

+

PROTEIN_ASSOCIATION: ( H16_A1051 ) or ( H16_A1052 ) or ( H16_A1050 ) or ( H16_A1055 ) or ( H16_A1056 ) or ( H16_A1053 ) or ( H16_A1054 ) or ( H16_A1061 ) or ( H16_A1060 ) or ( H16_A1063 ) or ( H16_A1062 ) or ( H16_A1059 ) or ( H16_A1058 ) or ( H16_A1057 ) or ( H16_A0251 )

+

SUBSYSTEM: Oxidative Phosphorylation

+

PROTEIN_CLASS: 1.6.5.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2606 )

+

PROTEIN_ASSOCIATION: ( H16_A2606 )

+

SUBSYSTEM: Selenoamino acid metabolism

+

PROTEIN_CLASS: 2.5.1.48

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1051 ) or ( H16_A1052 ) or ( H16_A1050 ) or ( H16_A1055 ) or ( H16_A1056 ) or ( H16_A1053 ) or ( H16_A1054 ) or ( H16_A1061 ) or ( H16_A1060 ) or ( H16_A1063 ) or ( H16_A1062 ) or ( H16_A1059 ) or ( H16_A1058 ) or ( H16_A1057 ) or ( H16_A0251 )

+

PROTEIN_ASSOCIATION: ( H16_A1051 ) or ( H16_A1052 ) or ( H16_A1050 ) or ( H16_A1055 ) or ( H16_A1056 ) or ( H16_A1053 ) or ( H16_A1054 ) or ( H16_A1061 ) or ( H16_A1060 ) or ( H16_A1063 ) or ( H16_A1062 ) or ( H16_A1059 ) or ( H16_A1058 ) or ( H16_A1057 ) or ( H16_A0251 )

+

SUBSYSTEM: Oxidative Phosphorylation

+

PROTEIN_CLASS: 1.6.5.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2606 )

+

PROTEIN_ASSOCIATION: ( H16_A2606 )

+

SUBSYSTEM: Selenoamino acid metabolism

+

PROTEIN_CLASS: 2.5.1.48

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Lipopolysaccharide Biosynthesis

+

PROTEIN_CLASS: 3.1.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2113 )

+

PROTEIN_ASSOCIATION: ( H16_A2113 )

+

SUBSYSTEM: Alanine and Aspartate Metabolism

+

PROTEIN_CLASS: 5.1.1.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1132 ) or ( H16_B0143 )

+

PROTEIN_ASSOCIATION: ( H16_A1132 ) or ( H16_B0143 )

+

SUBSYSTEM: Nicotinate and Nicotinamide metabolism

+

PROTEIN_CLASS: 2.7.1.23

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Thiamine Metabolism

+

PROTEIN_CLASS: 2.7.1.50

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2913 )

+

PROTEIN_ASSOCIATION: ( H16_A2913 )

+

SUBSYSTEM: Pyrimidine metabolism

+

PROTEIN_CLASS: 2.1.3.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2521 )

+

PROTEIN_ASSOCIATION: ( H16_A2521 )

+

SUBSYSTEM: Arginine and Proline metabolism

+

PROTEIN_CLASS: 2.6.1.21

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2521 )

+

PROTEIN_ASSOCIATION: ( H16_A2521 )

+

SUBSYSTEM: D-alanine metabolism

+

PROTEIN_CLASS: 2.6.1.21

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A0791 )

+

PROTEIN_ASSOCIATION: ( H16_A0791 )

+

SUBSYSTEM: Vitamine B6 metabolism

+

PROTEIN_CLASS: 2.6.1.52

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2521 )

+

PROTEIN_ASSOCIATION: ( H16_A2521 )

+

SUBSYSTEM: Phenylalanine metabolism

+

PROTEIN_CLASS: 2.6.1.21

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A0220 ) or ( H16_B0337 )

+

PROTEIN_ASSOCIATION: ( H16_A0220 ) or ( H16_B0337 )

+

SUBSYSTEM: Urea Cycle and Metabolism of amino groups

+

PROTEIN_CLASS: 1.2.1.38

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A0520 ) or ( H16_B0594 ) or ( H16_B1063 ) or ( H16_A0168 )

+

PROTEIN_ASSOCIATION: ( H16_A0520 ) or ( H16_B0594 ) or ( H16_B1063 ) or ( H16_A0168 )

+

SUBSYSTEM: Fructose and Mannose metabolism

+

PROTEIN_CLASS: 3.1.3.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1934 )

+

PROTEIN_ASSOCIATION: ( H16_A1934 )

+

SUBSYSTEM: Glycine, Serine and threonine Metabolism

+

PROTEIN_CLASS: 1.1.1.103

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Propanoate metabolism

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3348 ) or ( H16_A3141 )

+

PROTEIN_ASSOCIATION: ( H16_A3348 ) or ( H16_A3141 )

+

SUBSYSTEM: Lysine Biosynthesis

+

PROTEIN_CLASS: 1.3.1.26

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1670 ) or ( H16_B0324 )

+

PROTEIN_ASSOCIATION: ( H16_B1670 ) or ( H16_B0324 )

+

SUBSYSTEM: Tyrosine metabolism

+

PROTEIN_CLASS: 3.7.1.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B1631 ) or ( H16_B1871 )

+

PROTEIN_ASSOCIATION: ( H16_B1631 ) or ( H16_B1871 )

+

SUBSYSTEM: Pyruvate Metabolism

+

PROTEIN_CLASS: 2.3.1.8

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B0819 )

+

PROTEIN_ASSOCIATION: ( H16_B0819 )

+

SUBSYSTEM: Glycine, Serine and threonine Metabolism

+

PROTEIN_CLASS: 2.3.1.29

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A3075 ) or ( H16_A0068 )

+

PROTEIN_ASSOCIATION: ( H16_A3075 ) or ( H16_A0068 )

+

SUBSYSTEM: Pyrimidine metabolism

+

PROTEIN_CLASS: 3.5.2.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1527 )

+

PROTEIN_ASSOCIATION: ( H16_A1527 )

+

SUBSYSTEM: Nicotinate and Nicotinamide metabolism

+

PROTEIN_CLASS: 3.5.1.19

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1719 ) or ( H16_B1769 ) or ( H16_A1715 )

+

PROTEIN_ASSOCIATION: ( H16_B1719 ) or ( H16_B1769 ) or ( H16_A1715 )

+

SUBSYSTEM: Pantothenate and CoA biosynthesis

+

PROTEIN_CLASS: 1.1.1.169

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1322 )

+

PROTEIN_ASSOCIATION: ( H16_A1322 )

+

SUBSYSTEM: Glycerolipid Metabolism

+

PROTEIN_CLASS: 3.1.1.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Vitamine B6 metabolism

+

PROTEIN_CLASS: 1.2.1.72

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0548 ) or ( H16_B0597 ) or ( H16_B0884 )

+

PROTEIN_ASSOCIATION: ( H16_B0548 ) or ( H16_B0597 ) or ( H16_B0884 )

+

SUBSYSTEM: Toluene and Xylene degradation

+

PROTEIN_CLASS: 4.2.1.80

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1806 ) or ( H16_B0596 ) or ( H16_A2747 ) or ( H16_B0551 )

+

PROTEIN_ASSOCIATION: ( H16_A1806 ) or ( H16_B0596 ) or ( H16_A2747 ) or ( H16_B0551 )

+

SUBSYSTEM: Butanoate metabolism

+

PROTEIN_CLASS: 1.2.1.10

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A3063 )

+

PROTEIN_ASSOCIATION: ( H16_A3063 )

+

SUBSYSTEM: Arginine and Proline Metabolism

+

PROTEIN_CLASS: 2.1.3.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2376 )

+

PROTEIN_ASSOCIATION: ( H16_A2376 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 3.1.3.5

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Fatty acid biosynthesis

+

PROTEIN_CLASS: 2.3.1.41 2.3.1.179 2.3.1.180 1.1.1.100

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2376 )

+

PROTEIN_ASSOCIATION: ( H16_A2376 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 3.1.3.5

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1746 )

+

PROTEIN_ASSOCIATION: ( H16_B1746 )

+

SUBSYSTEM: Carprolactam degradation

+

PROTEIN_CLASS: 1.14.13.22

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2376 )

+

PROTEIN_ASSOCIATION: ( H16_A2376 )

+

SUBSYSTEM: Pyrimidine metabolism

+

PROTEIN_CLASS: 3.1.3.5

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2376 )

+

PROTEIN_ASSOCIATION: ( H16_A2376 )

+

SUBSYSTEM: Pyrimidine metabolism

+

PROTEIN_CLASS: 3.1.3.5

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2376 )

+

PROTEIN_ASSOCIATION: ( H16_A2376 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 3.1.3.5

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2376 )

+

PROTEIN_ASSOCIATION: ( H16_A2376 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 3.1.3.5

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0674 ) or ( H16_A1809 ) or ( H16_A0827 ) or ( H16_B0376 ) or ( H16_A1791 )

+

PROTEIN_ASSOCIATION: ( H16_A0674 ) or ( H16_A1809 ) or ( H16_A0827 ) or ( H16_B0376 ) or ( H16_A1791 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 4.6.1.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A0244 )

+

PROTEIN_ASSOCIATION: ( H16_A0244 )

+

SUBSYSTEM: Methionine Metabolism

+

PROTEIN_CLASS: 3.3.1.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0244 )

+

PROTEIN_ASSOCIATION: ( H16_A0244 )

+

SUBSYSTEM: Selenoamino acid metabolism

+

PROTEIN_CLASS: 3.3.1.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B1746 )

+

PROTEIN_ASSOCIATION: ( H16_B1746 )

+

SUBSYSTEM: Carprolactam degradation

+

PROTEIN_CLASS: 1.14.13.22

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Purine and Pyrimidine Biosynthesis

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0597 ) or ( H16_A3236 )

+

PROTEIN_ASSOCIATION: ( H16_A0597 ) or ( H16_A3236 )

+

SUBSYSTEM: Peptidoglycan Biosynthesis

+

PROTEIN_CLASS: 3.5.1.28

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A0570 ) or ( H16_A0571 )

+

PROTEIN_ASSOCIATION: ( H16_A0570 ) or ( H16_A0571 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 4.1.1.21

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0757 ) or ( H16_B1109 ) or ( H16_B1420 ) or ( H16_B0223 ) or ( H16_B1836 ) or ( H16_A0633 )

+

PROTEIN_ASSOCIATION: ( H16_B0757 ) or ( H16_B1109 ) or ( H16_B1420 ) or ( H16_B0223 ) or ( H16_B1836 ) or ( H16_A0633 )

+

SUBSYSTEM: Fluorene degradation

+

PROTEIN_CLASS: 1.13.11.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1013 )

+

PROTEIN_ASSOCIATION: ( H16_A1013 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 3.5.4.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2376 )

+

PROTEIN_ASSOCIATION: ( H16_A2376 )

+

SUBSYSTEM: Pyrimidine metabolism

+

PROTEIN_CLASS: 3.1.3.5

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2376 )

+

PROTEIN_ASSOCIATION: ( H16_A2376 )

+

SUBSYSTEM: Pyrimidine metabolism

+

PROTEIN_CLASS: 3.1.3.5

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2376 )

+

PROTEIN_ASSOCIATION: ( H16_A2376 )

+

SUBSYSTEM: Pyrimidine metabolism

+

PROTEIN_CLASS: 3.1.3.5

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Putative Transporters

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1447 )

+

PROTEIN_ASSOCIATION: ( H16_A1447 )

+

SUBSYSTEM: Selenoamino acid metabolism

+

PROTEIN_CLASS: 4.4.1.8

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1447 )

+

PROTEIN_ASSOCIATION: ( H16_A1447 )

+

SUBSYSTEM: Cysteine Metabolism

+

PROTEIN_CLASS: 4.4.1.8

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0395 )

+

PROTEIN_ASSOCIATION: ( H16_A0395 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 2.4.2.7

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0521 ) or ( H16_A0523 )

+

PROTEIN_ASSOCIATION: ( H16_A0521 ) or ( H16_A0523 )

+

SUBSYSTEM: Aminoacyl-tRNA Biosynthesis

+

PROTEIN_CLASS: 6.1.1.14

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2621 and H16_A2620 ) or ( H16_B0051 and H16_B0052 ) or ( H16_B2276 and H16_B2275 ) or ( H16_A1549 and H16_A1550 ) or ( H16_A1236 and H16_A1237 )

+

PROTEIN_ASSOCIATION: ( H16_A2621_and_H16_A2620 ) or ( H16_B0051_and_H16_B0052 ) or ( H16_B2276_and_H16_B2275 ) or ( H16_A1549_and_H16_A1550 ) or ( H16_A1236_and_H16_A1237 )

+

SUBSYSTEM: Valine, Leucine and Isoleucine Biosynthesis

+

PROTEIN_CLASS: 4.2.1.33

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1447 )

+

PROTEIN_ASSOCIATION: ( H16_A1447 )

+

SUBSYSTEM: Methionine Metabolism

+

PROTEIN_CLASS: 4.4.1.8

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2621 and H16_A2620 ) or ( H16_B0051 and H16_B0052 ) or ( H16_B2276 and H16_B2275 ) or ( H16_A1549 and H16_A1550 ) or ( H16_A1236 and H16_A1237 )

+

PROTEIN_ASSOCIATION: ( H16_A2621_and_H16_A2620 ) or ( H16_B0051_and_H16_B0052 ) or ( H16_B2276_and_H16_B2275 ) or ( H16_A1549_and_H16_A1550 ) or ( H16_A1236_and_H16_A1237 )

+

SUBSYSTEM: Valine, Leucine and Isoleucine Biosynthesis

+

PROTEIN_CLASS: 4.2.1.33

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B2566 ) or ( H16_B1501 ) or ( H16_A0316 )

+

PROTEIN_ASSOCIATION: ( H16_B2566 ) or ( H16_B1501 ) or ( H16_A0316 )

+

SUBSYSTEM: Pentose Phosphate Pathway

+

PROTEIN_CLASS: 1.1.1.49

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A3186 )

+

PROTEIN_ASSOCIATION: ( H16_A3186 )

+

SUBSYSTEM: Galactose metabolism

+

PROTEIN_CLASS: 1.1.1.21

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2129 ) or ( H16_B0738 ) or ( H16_B0730 )

+

PROTEIN_ASSOCIATION: ( H16_B2129 ) or ( H16_B0738 ) or ( H16_B0730 )

+

SUBSYSTEM: Naphthalene and Anthracene degradation

+

PROTEIN_CLASS: 1.14.-.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0674 ) or ( H16_A1809 ) or ( H16_A0827 ) or ( H16_B0376 ) or ( H16_A1791 )

+

PROTEIN_ASSOCIATION: ( H16_A0674 ) or ( H16_A1809 ) or ( H16_A0827 ) or ( H16_B0376 ) or ( H16_A1791 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 4.6.1.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1962 and H16_A1961 and H16_A1963 )

+

PROTEIN_ASSOCIATION: ( H16_A1962_and_H16_A1961_and_H16_A1963 )

+

SUBSYSTEM: Fluorobenzoate degradation

+

PROTEIN_CLASS: 1.14.12.10

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1962 and H16_A1961 and H16_A1963 )

+

PROTEIN_ASSOCIATION: ( H16_A1962_and_H16_A1961_and_H16_A1963 )

+

SUBSYSTEM: Fluorobenzoate degradation

+

PROTEIN_CLASS: 1.14.12.10

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2761 )

+

PROTEIN_ASSOCIATION: ( H16_A2761 )

+

SUBSYSTEM: Nicotinate and Nicotinamide metabolism

+

PROTEIN_CLASS: 3.6.1.22

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0548 ) or ( H16_B0597 ) or ( H16_B0884 ) or ( H16_A0143 )

+

PROTEIN_ASSOCIATION: ( H16_B0548 ) or ( H16_B0597 ) or ( H16_B0884 ) or ( H16_A0143 )

+

SUBSYSTEM: Phenylalanine metabolism

+

PROTEIN_CLASS: 4.2.1.80

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0330 )

+

PROTEIN_ASSOCIATION: ( H16_B0330 )

+

SUBSYSTEM: Tryptophan metabolism

+

PROTEIN_CLASS: 4.1.1.45

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1962 and H16_A1961 and H16_A1963 )

+

PROTEIN_ASSOCIATION: ( H16_A1962_and_H16_A1961_and_H16_A1963 )

+

SUBSYSTEM: Fluorobenzoate degradation

+

PROTEIN_CLASS: 1.14.12.10

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1962 and H16_A1961 and H16_A1963 )

+

PROTEIN_ASSOCIATION: ( H16_A1962_and_H16_A1961_and_H16_A1963 )

+

SUBSYSTEM: Fluorobenzoate degradation

+

PROTEIN_CLASS: 1.14.12.10

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1962 and H16_A1961 and H16_A1963 )

+

PROTEIN_ASSOCIATION: ( H16_A1962_and_H16_A1961_and_H16_A1963 )

+

SUBSYSTEM: Fluorobenzoate degradation

+

PROTEIN_CLASS: 1.14.12.10

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2761 )

+

PROTEIN_ASSOCIATION: ( H16_A2761 )

+

SUBSYSTEM: Nicotinate and Nicotinamide metabolism

+

PROTEIN_CLASS: 3.6.1.22

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1864 )

+

PROTEIN_ASSOCIATION: ( H16_A1864 )

+

SUBSYSTEM: Nucleotide sugars metabolism

+

PROTEIN_CLASS: 2.7.7.24

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1962 and H16_A1961 and H16_A1963 )

+

PROTEIN_ASSOCIATION: ( H16_A1962_and_H16_A1961_and_H16_A1963 )

+

SUBSYSTEM: Benzoate degradation via CoA ligation

+

PROTEIN_CLASS: 1.14.12.10

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2618 )

+

PROTEIN_ASSOCIATION: ( H16_A2618 )

+

SUBSYSTEM: Glycine, Serine and threonine Metabolism

+

PROTEIN_CLASS: 1.2.1.11

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A0395 )

+

PROTEIN_ASSOCIATION: ( H16_A0395 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 2.4.2.7

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2470 ) or ( H16_B0517 ) or ( H16_A3330 ) or ( H16_B1433 ) or ( H16_A0757 ) or ( H16_B1699 ) or ( H16_B1834 ) or ( H16_B1745 )

+

PROTEIN_ASSOCIATION: ( H16_B2470 ) or ( H16_B0517 ) or ( H16_A3330 ) or ( H16_B1433 ) or ( H16_A0757 ) or ( H16_B1699 ) or ( H16_B1834 ) or ( H16_B1745 )

+

SUBSYSTEM: 1- and 2-Methylnaphthalene degradation

+

PROTEIN_CLASS: 1.1.1.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A0395 )

+

PROTEIN_ASSOCIATION: ( H16_A0395 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 2.4.2.7

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A3242 )

+

PROTEIN_ASSOCIATION: ( H16_A3242 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 2.4.2.8

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Fatty acid biosynthesis

+

PROTEIN_CLASS: 2.3.1.41 2.3.1.179 2.3.1.86 2.3.1.41

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B2289 ) or ( H16_A2422 )

+

PROTEIN_ASSOCIATION: ( H16_B2289 ) or ( H16_A2422 )

+

SUBSYSTEM: Benzoate degradation via Hydroxylation

+

PROTEIN_CLASS: 5.5.1.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Fatty acid biosynthesis

+

PROTEIN_CLASS: 2.3.1.41 2.3.1.179 2.3.1.86 2.3.1.41

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A3056 ) or ( H16_B1931 )

+

PROTEIN_ASSOCIATION: ( H16_A3056 ) or ( H16_B1931 )

+

SUBSYSTEM: Citric Acid Cycle

+

PROTEIN_CLASS: 1.1.1.42

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2129 ) or ( H16_B0738 ) or ( H16_B0730 )

+

PROTEIN_ASSOCIATION: ( H16_B2129 ) or ( H16_B0738 ) or ( H16_B0730 )

+

SUBSYSTEM: Naphthalene and Anthracene degradation

+

PROTEIN_CLASS: 1.14.-.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3322 )

+

PROTEIN_ASSOCIATION: ( H16_A3322 )

+

SUBSYSTEM: Phenylalanine, Tyrosine and Tryptophan biosynthesis

+

PROTEIN_CLASS: 4.1.1.48

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B1593 ) or ( H16_A0782 )

+

PROTEIN_ASSOCIATION: ( H16_B1593 ) or ( H16_A0782 )

+

SUBSYSTEM: Pyrimidine metabolism

+

PROTEIN_CLASS: 3.5.4.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B1195 )

+

PROTEIN_ASSOCIATION: ( H16_B1195 )

+

SUBSYSTEM: Methane Metabolism

+

PROTEIN_CLASS: 1.1.1.284

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0208 )

+

PROTEIN_ASSOCIATION: ( H16_B0208 )

+

SUBSYSTEM: Biosynthesis of steroids

+

PROTEIN_CLASS: 2.5.1.21

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Benzoate degradation via Hydroxylation

+

PROTEIN_CLASS: 1.14.12.1

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0208 )

+

PROTEIN_ASSOCIATION: ( H16_B0208 )

+

SUBSYSTEM: Biosynthesis of steroids

+

PROTEIN_CLASS: 2.5.1.21

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1559 )

+

PROTEIN_ASSOCIATION: ( H16_B1559 )

+

SUBSYSTEM: Starch and sucrose metabolism

+

PROTEIN_CLASS: 2.4.1.18

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3633 )

+

PROTEIN_ASSOCIATION: ( H16_A3633 )

+

SUBSYSTEM: Porphyrin and Chlorophyll metabolism

+

PROTEIN_CLASS: 4.1.1.37

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3633 )

+

PROTEIN_ASSOCIATION: ( H16_A3633 )

+

SUBSYSTEM: Porphyrin and Chlorophyll metabolism

+

PROTEIN_CLASS: 4.1.1.37

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A3161 )

+

PROTEIN_ASSOCIATION: ( H16_A3161 )

+

SUBSYSTEM: Phenylalanine, Tyrosine and Tryptophan biosynthesis

+

PROTEIN_CLASS: 1.1.1.25

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1581 )

+

PROTEIN_ASSOCIATION: ( H16_B1581 )

+

SUBSYSTEM: Methionine Metabolism

+

PROTEIN_CLASS: 2.1.1.14

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Vitamine B6 metabolism

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0606 )

+

PROTEIN_ASSOCIATION: ( H16_A0606 )

+

SUBSYSTEM: Lipopolysaccharide Biosynthesis

+

PROTEIN_CLASS: 2.7.1.130

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0538 ) or ( H16_A3452 ) or ( H16_A0711 ) or ( H16_A0728 ) or ( H16_A1904 ) or ( H16_B0193 ) or ( H16_A2711 ) or ( H16_B2325 ) or ( H16_B2032 ) or ( H16_A1118 ) or ( H16_B0187 ) or ( H16_A3617 ) or ( H16_A0917 ) or ( H16_A1282 ) or ( H16_A2943 ) or ( H16_B1613 ) or ( H16_A3646 ) or ( H16_A0983 ) or ( H16_B1571 ) or ( H16_A2322 ) or ( H16_A0260 ) or ( H16_A3250 ) or ( H16_B2575 ) or ( H16_A2683 )

+

PROTEIN_ASSOCIATION: ( H16_B0538 ) or ( H16_A3452 ) or ( H16_A0711 ) or ( H16_A0728 ) or ( H16_A1904 ) or ( H16_B0193 ) or ( H16_A2711 ) or ( H16_B2325 ) or ( H16_B2032 ) or ( H16_A1118 ) or ( H16_B0187 ) or ( H16_A3617 ) or ( H16_A0917 ) or ( H16_A1282 ) or ( H16_A2943 ) or ( H16_B1613 ) or ( H16_A3646 ) or ( H16_A0983 ) or ( H16_B1571 ) or ( H16_A2322 ) or ( H16_A0260 ) or ( H16_A3250 ) or ( H16_B2575 ) or ( H16_A2683 )

+

SUBSYSTEM: Folate Biosynthesis

+

PROTEIN_CLASS: 3.6.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Oxidative Phosphorylation

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2921 )

+

PROTEIN_ASSOCIATION: ( H16_A2921 )

+

SUBSYSTEM: Anaplerotic Reactions

+

PROTEIN_CLASS: 4.1.1.31

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3325 )

+

PROTEIN_ASSOCIATION: ( H16_A3325 )

+

SUBSYSTEM: Glycolysis/Gluconeogenesis

+

PROTEIN_CLASS: 3.6.1.7

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3325 )

+

PROTEIN_ASSOCIATION: ( H16_A3325 )

+

SUBSYSTEM: Pyruvate Metabolism

+

PROTEIN_CLASS: 3.6.1.7

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A3025 ) or ( H16_A2065 )

+

PROTEIN_ASSOCIATION: ( H16_A3025 ) or ( H16_A2065 )

+

SUBSYSTEM: Lysine Biosynthesis

+

PROTEIN_CLASS: 2.6.1.17

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3325 )

+

PROTEIN_ASSOCIATION: ( H16_A3325 )

+

SUBSYSTEM: Benzoate degradation via CoA ligation

+

PROTEIN_CLASS: 3.6.1.7

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1122 ) or ( H16_B1076 )

+

PROTEIN_ASSOCIATION: ( H16_A1122 ) or ( H16_B1076 )

+

SUBSYSTEM: Phenylalanine, Tyrosine and Tryptophan biosynthesis

+

PROTEIN_CLASS: 2.5.1.54

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2925 )

+

PROTEIN_ASSOCIATION: ( H16_A2925 )

+

SUBSYSTEM: Arginine and Proline Metabolism

+

PROTEIN_CLASS: 4.3.2.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2447 )

+

PROTEIN_ASSOCIATION: ( H16_B2447 )

+

SUBSYSTEM: Tryptophan metabolism

+

PROTEIN_CLASS: 4.1.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2447 )

+

PROTEIN_ASSOCIATION: ( H16_B2447 )

+

SUBSYSTEM: Tyrosine metabolism

+

PROTEIN_CLASS: 4.1.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2447 )

+

PROTEIN_ASSOCIATION: ( H16_B2447 )

+

SUBSYSTEM: 1,1,1-Trichloro-2,2-Bis-(Chlorophenyl)Ethane (DDT) degradation

+

PROTEIN_CLASS: 4.1.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2447 )

+

PROTEIN_ASSOCIATION: ( H16_B2447 )

+

SUBSYSTEM: 3-Chloroacrylic acid degradation

+

PROTEIN_CLASS: 4.1.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3123 )

+

PROTEIN_ASSOCIATION: ( H16_A3123 )

+

SUBSYSTEM: Oxidative Phosphorylation

+

PROTEIN_CLASS: 1.2.2.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2447 )

+

PROTEIN_ASSOCIATION: ( H16_B2447 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 4.1.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2447 )

+

PROTEIN_ASSOCIATION: ( H16_B2447 )

+

SUBSYSTEM: Pyruvate Metabolism

+

PROTEIN_CLASS: 4.1.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2447 )

+

PROTEIN_ASSOCIATION: ( H16_B2447 )

+

SUBSYSTEM: Tyrosine metabolism

+

PROTEIN_CLASS: 4.1.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1139 )

+

PROTEIN_ASSOCIATION: ( H16_A1139 )

+

SUBSYSTEM: Glycerophospholipid Metabolism

+

PROTEIN_CLASS: 3.1.1.32

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2447 )

+

PROTEIN_ASSOCIATION: ( H16_B2447 )

+

SUBSYSTEM: Tyrosine metabolism

+

PROTEIN_CLASS: 4.1.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2204 ) or ( H16_A2643 ) or ( H16_A1603 ) or ( H16_A2647 )

+

PROTEIN_ASSOCIATION: ( H16_A2204 ) or ( H16_A2643 ) or ( H16_A1603 ) or ( H16_A2647 )

+

SUBSYSTEM: Ubiquinone Biosynthesis

+

PROTEIN_CLASS: 2.5.1.16

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2204 ) or ( H16_A2643 ) or ( H16_A1603 ) or ( H16_A2647 )

+

PROTEIN_ASSOCIATION: ( H16_A2204 ) or ( H16_A2643 ) or ( H16_A1603 ) or ( H16_A2647 )

+

SUBSYSTEM: Urea Cycle and Metabolism of amino groups

+

PROTEIN_CLASS: 2.5.1.16

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2964 ) or ( H16_A2963 )

+

PROTEIN_ASSOCIATION: ( H16_A2964 ) or ( H16_A2963 )

+

SUBSYSTEM: Porphyrin and Chlorophyll metabolism

+

PROTEIN_CLASS: 6.3.1.10

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2964 ) or ( H16_A2963 )

+

PROTEIN_ASSOCIATION: ( H16_A2964 ) or ( H16_A2963 )

+

SUBSYSTEM: Porphyrin and Chlorophyll metabolism

+

PROTEIN_CLASS: 6.3.1.10

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2447 )

+

PROTEIN_ASSOCIATION: ( H16_B2447 )

+

SUBSYSTEM: Benzoate degradation via Hydroxylation

+

PROTEIN_CLASS: 4.1.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3598 )

+

PROTEIN_ASSOCIATION: ( H16_A3598 )

+

SUBSYSTEM: Glyoxylate and Dicarboxylate metabolism

+

PROTEIN_CLASS: 4.1.1.47

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3435 )

+

PROTEIN_ASSOCIATION: ( H16_A3435 )

+

SUBSYSTEM: Phenylalanine, Tyrosine and Tryptophan biosynthesis

+

PROTEIN_CLASS: 2.7.1.71

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2930 )

+

PROTEIN_ASSOCIATION: ( H16_A2930 )

+

SUBSYSTEM: Urea Cycle and Metabolism of amino groups

+

PROTEIN_CLASS: 4.1.1.19

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0787 ) or ( H16_A1649 )

+

PROTEIN_ASSOCIATION: ( H16_A0787 ) or ( H16_A1649 )

+

SUBSYSTEM: Ubiquinone Biosynthesis

+

PROTEIN_CLASS: 2.1.1.64

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2968 )

+

PROTEIN_ASSOCIATION: ( H16_A2968 )

+

SUBSYSTEM: Rivoflavin metabolism

+

PROTEIN_CLASS: 2.4.2.21

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3258 )

+

PROTEIN_ASSOCIATION: ( H16_A3258 )

+

SUBSYSTEM: Pantothenate and CoA biosynthesis

+

PROTEIN_CLASS: 2.7.1.24

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0948 )

+

PROTEIN_ASSOCIATION: ( H16_A0948 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 3.6.1.15

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0948 )

+

PROTEIN_ASSOCIATION: ( H16_A0948 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 3.6.1.15

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3046 )

+

PROTEIN_ASSOCIATION: ( H16_A3046 )

+

SUBSYSTEM: Aminoacyl-tRNA Biosynthesi

+

PROTEIN_CLASS: 6.1.1.5

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2962 )

+

PROTEIN_ASSOCIATION: ( H16_A2962 )

+

SUBSYSTEM: Porphyrin and Chlorophyll metabolism

+

PROTEIN_CLASS: 2.7.7.62

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A1905 )

+

PROTEIN_ASSOCIATION: ( H16_A1905 )

+

SUBSYSTEM: Propanoate metabolism

+

PROTEIN_CLASS: 4.1.3.30

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2038 )

+

PROTEIN_ASSOCIATION: ( H16_A2038 )

+

SUBSYSTEM: Pyruvate Metabolism

+

PROTEIN_CLASS: 2.7.9.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: 1,4-Dichlorobenzene degradation

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Ubiquinone Biosynthesis

+

PROTEIN_CLASS: 1.14.13.-

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0323 )

+

PROTEIN_ASSOCIATION: ( H16_A0323 )

+

SUBSYSTEM: Glutamate metabolism

+

PROTEIN_CLASS: 6.3.2.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B1584 ) or ( H16_A1967 )

+

PROTEIN_ASSOCIATION: ( H16_B1584 ) or ( H16_A1967 )

+

SUBSYSTEM: Benzoate degradation via Hydroxylation

+

PROTEIN_CLASS: 5.3.3.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1511 )

+

PROTEIN_ASSOCIATION: ( H16_A1511 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 6.3.5.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1313 ) or ( H16_B2229 )

+

PROTEIN_ASSOCIATION: ( H16_A1313 ) or ( H16_B2229 )

+

SUBSYSTEM: Cysteine Metabolism

+

PROTEIN_CLASS: 2.5.1.49

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0847 ) or ( H16_B0367 ) or ( H16_B0655 ) or ( H16_B0656 ) or ( H16_B0914 ) or ( H16_B0355 ) or ( H16_B0488 )

+

PROTEIN_ASSOCIATION: ( H16_B0847 ) or ( H16_B0367 ) or ( H16_B0655 ) or ( H16_B0656 ) or ( H16_B0914 ) or ( H16_B0355 ) or ( H16_B0488 )

+

SUBSYSTEM: 1- and 2-Methylnaphthalene degradation

+

PROTEIN_CLASS: 2.8.3.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3087 )

+

PROTEIN_ASSOCIATION: ( H16_A3087 )

+

SUBSYSTEM: Folate Biosynthesis

+

PROTEIN_CLASS: 4.1.3.38

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2959 )

+

PROTEIN_ASSOCIATION: ( H16_A2959 )

+

SUBSYSTEM: Pantothenate and CoA biosynthesis

+

PROTEIN_CLASS: 6.3.2.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B0131 )

+

PROTEIN_ASSOCIATION: ( H16_B0131 )

+

SUBSYSTEM: Ascorbate and Aldarate metabolism

+

PROTEIN_CLASS: 4.2.1.41

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1313 ) or ( H16_B2229 )

+

PROTEIN_ASSOCIATION: ( H16_A1313 ) or ( H16_B2229 )

+

SUBSYSTEM: Methionine Metabolism

+

PROTEIN_CLASS: 2.5.1.49

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2049 )

+

PROTEIN_ASSOCIATION: ( H16_A2049 )

+

SUBSYSTEM: Biosynthesis of steroids

+

PROTEIN_CLASS: 1.1.1.267

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Putative Transporters

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Putative Transporters

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1956 )

+

PROTEIN_ASSOCIATION: ( H16_A1956 )

+

SUBSYSTEM: Styrene degradation

+

PROTEIN_CLASS: 3.5.5.7

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2434 ) or ( H16_A0520 ) or ( H16_B0594 ) or ( H16_B1063 ) or ( H16_A0786 ) or ( H16_A2577 ) or ( H16_B2398 )

+

PROTEIN_ASSOCIATION: ( H16_A2434 ) or ( H16_A0520 ) or ( H16_B0594 ) or ( H16_B1063 ) or ( H16_A0786 ) or ( H16_A2577 ) or ( H16_B2398 )

+

SUBSYSTEM: Rivoflavin metabolism

+

PROTEIN_CLASS: 3.1.3.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1399 )

+

PROTEIN_ASSOCIATION: ( H16_B1399 )

+

SUBSYSTEM: Tryptophan metabolism

+

PROTEIN_CLASS: 4.1.1.74

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2009 )

+

PROTEIN_ASSOCIATION: ( H16_A2009 )

+

SUBSYSTEM: Taurine and Hypotaurine metabolism

+

PROTEIN_CLASS: 1.4.1.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3366 ) or ( H16_A3372 ) or ( H16_A3344 ) or ( H16_A2859 )

+

PROTEIN_ASSOCIATION: ( H16_A3366 ) or ( H16_A3372 ) or ( H16_A3344 ) or ( H16_A2859 )

+

SUBSYSTEM: Ubiquinone Biosynthesis

+

PROTEIN_CLASS: 4.1.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Glycerophospholipid Metabolism

+

PROTEIN_CLASS: 2.3.1.15

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1960 )

+

PROTEIN_ASSOCIATION: ( H16_A1960 )

+

SUBSYSTEM: Fluorobenzoate degradation

+

PROTEIN_CLASS: 1.3.1.25

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1960 )

+

PROTEIN_ASSOCIATION: ( H16_A1960 )

+

SUBSYSTEM: Fluorobenzoate degradation

+

PROTEIN_CLASS: 1.3.1.25

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1265 and H16_A1264 and H16_B1714 and H16_A3131 and H16_B1715 and H16_A3130 and H16_A0852 and H16_A0850 and H16_A1266 and H16_A0851 and H16_A3128 )

+

PROTEIN_ASSOCIATION: ( H16_A1265_and_H16_A1264_and_H16_B1714_and_H16_A3131_and_H16_B1715_and_H16_A3130_and_H16_A0852_and_H16_A0850_and_H16_A1266_and_H16_A0851_and_H16_A3128 )

+

SUBSYSTEM: Oxidative Phosphorylation

+

PROTEIN_CLASS: 1.6.1.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1960 )

+

PROTEIN_ASSOCIATION: ( H16_A1960 )

+

SUBSYSTEM: Fluorobenzoate degradation

+

PROTEIN_CLASS: 1.3.1.25

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1960 )

+

PROTEIN_ASSOCIATION: ( H16_A1960 )

+

SUBSYSTEM: Benzoate degradation via CoA ligation

+

PROTEIN_CLASS: 1.3.1.25

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A3600 )

+

PROTEIN_ASSOCIATION: ( H16_A3600 )

+

SUBSYSTEM: Glyoxylate and Dicarboxylate metabolism

+

PROTEIN_CLASS: 1.1.1.60

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0219 ) or ( H16_B2397 ) or ( H16_B1899 ) or ( H16_A3529 ) or ( H16_B0018 ) or ( H16_A0269 ) or ( H16_A1564 ) or ( H16_A1683 ) or ( H16_A0699 ) or ( H16_B1278 ) or ( H16_A3586 ) or ( H16_B1407 ) or ( H16_A0240 ) or ( H16_A3093 ) or ( H16_A0039 ) or ( H16_A1802 ) or ( H16_A1315 ) or ( H16_B1292 ) or ( H16_A3221 ) or ( H16_B0032 ) or ( H16_B1663 ) or ( H16_A2759 ) or ( H16_A3071 ) or ( H16_B0021 )

+

PROTEIN_ASSOCIATION: ( H16_B0219 ) or ( H16_B2397 ) or ( H16_B1899 ) or ( H16_A3529 ) or ( H16_B0018 ) or ( H16_A0269 ) or ( H16_A1564 ) or ( H16_A1683 ) or ( H16_A0699 ) or ( H16_B1278 ) or ( H16_A3586 ) or ( H16_B1407 ) or ( H16_A0240 ) or ( H16_A3093 ) or ( H16_A0039 ) or ( H16_A1802 ) or ( H16_A1315 ) or ( H16_B1292 ) or ( H16_A3221 ) or ( H16_B0032 ) or ( H16_B1663 ) or ( H16_A2759 ) or ( H16_A3071 ) or ( H16_B0021 )

+

SUBSYSTEM: 1- and 2-Methylnaphthalene degradation

+

PROTEIN_CLASS: 2.3.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0367 )

+

PROTEIN_ASSOCIATION: ( H16_A0367 )

+

SUBSYSTEM: Pantothenate and CoA biosynthesis

+

PROTEIN_CLASS: 2.7.7.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1850 ) or ( H16_A2908 )

+

PROTEIN_ASSOCIATION: ( H16_A1850 ) or ( H16_A2908 )

+

SUBSYSTEM: Nucleotide sugars metabolism

+

PROTEIN_CLASS: 1.1.1.133

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2945 )

+

PROTEIN_ASSOCIATION: ( H16_A2945 )

+

SUBSYSTEM: Aminoacyl-tRNA Biosynthesis

+

PROTEIN_CLASS: 6.1.1.10

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2612 and H16_A2614 )

+

PROTEIN_ASSOCIATION: ( H16_A2612_and_H16_A2614 )

+

SUBSYSTEM: Phenylalanine, Tyrosine and Tryptophan biosynthesis

+

PROTEIN_CLASS: 4.2.1.20

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2612 and H16_A2614 )

+

PROTEIN_ASSOCIATION: ( H16_A2612_and_H16_A2614 )

+

SUBSYSTEM: Phenylalanine, Tyrosine and Tryptophan biosynthesis

+

PROTEIN_CLASS: 4.2.1.20

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0549 )

+

PROTEIN_ASSOCIATION: ( H16_B0549 )

+

SUBSYSTEM: Benzoate degradation via Hydroxylation

+

PROTEIN_CLASS: 4.1.1.77

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0549 )

+

PROTEIN_ASSOCIATION: ( H16_B0549 )

+

SUBSYSTEM: Toluene and Xylene degradation

+

PROTEIN_CLASS: 4.1.1.77

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3678 )

+

PROTEIN_ASSOCIATION: ( H16_A3678 )

+

SUBSYSTEM: Phenylalanine, Tyrosine and Tryptophan biosynthesis

+

PROTEIN_CLASS: 1.14.16.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0243 )

+

PROTEIN_ASSOCIATION: ( H16_A0243 )

+

SUBSYSTEM: Thiamine Metabolism

+

PROTEIN_CLASS: 2.7.4.7

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0374 )

+

PROTEIN_ASSOCIATION: ( H16_A0374 )

+

SUBSYSTEM: Biosynthesis of steroids

+

PROTEIN_CLASS: 2.7.1.148

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2612 and H16_A2614 )

+

PROTEIN_ASSOCIATION: ( H16_A2612_and_H16_A2614 )

+

SUBSYSTEM: Phenylalanine, Tyrosine and Tryptophan biosynthesis

+

PROTEIN_CLASS: 4.2.1.20

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2911 ) or ( H16_A0519 )

+

PROTEIN_ASSOCIATION: ( H16_A2911 ) or ( H16_A0519 )

+

SUBSYSTEM: Glycerophospholipid Metabolism

+

PROTEIN_CLASS: 2.3.1.51

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1070 ) or ( H16_B0359 ) or ( H16_A1069 ) or ( H16_A2151 ) or ( H16_A1289 ) or ( H16_A3307 ) or ( H16_B0706 )

+

PROTEIN_ASSOCIATION: ( H16_A1070 ) or ( H16_B0359 ) or ( H16_A1069 ) or ( H16_A2151 ) or ( H16_A1289 ) or ( H16_A3307 ) or ( H16_B0706 )

+

SUBSYSTEM: 1- and 2-Methylnaphthalene degradation

+

PROTEIN_CLASS: 4.2.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B1388 ) or ( H16_A3147 )

+

PROTEIN_ASSOCIATION: ( H16_B1388 ) or ( H16_A3147 )

+

SUBSYSTEM: Pentose Phosphate Pathway

+

PROTEIN_CLASS: 2.2.1.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B1388 ) or ( H16_A3147 )

+

PROTEIN_ASSOCIATION: ( H16_B1388 ) or ( H16_A3147 )

+

SUBSYSTEM: Pentose Phosphate Pathway

+

PROTEIN_CLASS: 2.2.1.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1017 ) or ( H16_B1897 ) or ( H16_B1898 ) or ( H16_A3371 ) or ( H16_A1016 )

+

PROTEIN_ASSOCIATION: ( H16_A1017 ) or ( H16_B1897 ) or ( H16_B1898 ) or ( H16_A3371 ) or ( H16_A1016 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 1.17.1.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1583 ) or ( H16_A1968 ) or ( H16_A0147 )

+

PROTEIN_ASSOCIATION: ( H16_B1583 ) or ( H16_A1968 ) or ( H16_A0147 )

+

SUBSYSTEM: Benzoate degradation via Hydroxylation

+

PROTEIN_CLASS: 3.1.1.24

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A3186 )

+

PROTEIN_ASSOCIATION: ( H16_A3186 )

+

SUBSYSTEM: Pentose and glucuronate interconversion

+

PROTEIN_CLASS: 1.1.1.21

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B2470 ) or ( H16_B0517 ) or ( H16_A3330 ) or ( H16_B1433 ) or ( H16_A0757 ) or ( H16_B1699 ) or ( H16_B1834 ) or ( H16_B1745 )

+

PROTEIN_ASSOCIATION: ( H16_B2470 ) or ( H16_B0517 ) or ( H16_A3330 ) or ( H16_B1433 ) or ( H16_A0757 ) or ( H16_B1699 ) or ( H16_B1834 ) or ( H16_B1745 )

+

SUBSYSTEM: Tyrosine metabolism

+

PROTEIN_CLASS: 1.1.1.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3319 and H16_A3320 )

+

PROTEIN_ASSOCIATION: ( H16_A3319_and_H16_A3320 )

+

SUBSYSTEM: Phenylalanine, Tyrosine and Tryptophan biosynthesis

+

PROTEIN_CLASS: 4.1.3.27

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Peptidoglycan Biosynthesis

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0230 ) or ( H16_A1975 )

+

PROTEIN_ASSOCIATION: ( H16_A0230 ) or ( H16_A1975 )

+

SUBSYSTEM: Selenoamino acid metabolism

+

PROTEIN_CLASS: 2.5.1.6

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Aminosugars metabolism

+

PROTEIN_CLASS: 5.1.3.7

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B1558 ) or ( H16_B1564 )

+

PROTEIN_ASSOCIATION: ( H16_B1558 ) or ( H16_B1564 )

+

SUBSYSTEM: Starch and sucrose metabolism

+

PROTEIN_CLASS: 5.4.99.16

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1191 ) or ( H16_A3664 ) or ( H16_A0273 )

+

PROTEIN_ASSOCIATION: ( H16_B1191 ) or ( H16_A3664 ) or ( H16_A0273 )

+

SUBSYSTEM: Propanoate metabolism

+

PROTEIN_CLASS: 1.2.1.27

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2470 ) or ( H16_B0517 ) or ( H16_A3330 ) or ( H16_B1433 ) or ( H16_A0757 ) or ( H16_B1699 ) or ( H16_B1834 ) or ( H16_B1745 )

+

PROTEIN_ASSOCIATION: ( H16_B2470 ) or ( H16_B0517 ) or ( H16_A3330 ) or ( H16_B1433 ) or ( H16_A0757 ) or ( H16_B1699 ) or ( H16_B1834 ) or ( H16_B1745 )

+

SUBSYSTEM: 3-Chloroacrylic acid degradation

+

PROTEIN_CLASS: 1.1.1.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2376 )

+

PROTEIN_ASSOCIATION: ( H16_A2376 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 3.1.3.5

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3049 )

+

PROTEIN_ASSOCIATION: ( H16_A3049 )

+

SUBSYSTEM: Pyrimidine metabolism

+

PROTEIN_CLASS: 3.6.1.23

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0208 )

+

PROTEIN_ASSOCIATION: ( H16_A0208 )

+

SUBSYSTEM: Urea Cycle and Metabolism of amino groups

+

PROTEIN_CLASS: 2.7.2.8

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2376 )

+

PROTEIN_ASSOCIATION: ( H16_A2376 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 3.1.3.5

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1655 ) or ( H16_A3737 ) or ( H16_A3663 ) or ( H16_B2131 ) or ( H16_A0233 )

+

PROTEIN_ASSOCIATION: ( H16_A1655 ) or ( H16_A3737 ) or ( H16_A3663 ) or ( H16_B2131 ) or ( H16_A0233 )

+

SUBSYSTEM: Glycine, Serine and threonine Metabolism

+

PROTEIN_CLASS: 1.1.99.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1655 ) or ( H16_A3737 ) or ( H16_A3663 ) or ( H16_B2131 ) or ( H16_A0233 )

+

PROTEIN_ASSOCIATION: ( H16_A1655 ) or ( H16_A3737 ) or ( H16_A3663 ) or ( H16_B2131 ) or ( H16_A0233 )

+

SUBSYSTEM: Glycine, Serine and threonine Metabolism

+

PROTEIN_CLASS: 1.1.99.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2733 )

+

PROTEIN_ASSOCIATION: ( H16_A2733 )

+

SUBSYSTEM: Biosynthesis of steroids

+

PROTEIN_CLASS: 2.5.1.10

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1223 ) or ( H16_B0632 ) or ( H16_A0615 )

+

PROTEIN_ASSOCIATION: ( H16_B1223 ) or ( H16_B0632 ) or ( H16_A0615 )

+

SUBSYSTEM: Tyrosine metabolism

+

PROTEIN_CLASS: 4.1.2.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Vitamine B6 metabolism

+

PROTEIN_CLASS: 3.1.3.74

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1223 ) or ( H16_B0632 ) or ( H16_A0615 )

+

PROTEIN_ASSOCIATION: ( H16_B1223 ) or ( H16_B0632 ) or ( H16_A0615 )

+

SUBSYSTEM: Tyrosine metabolism

+

PROTEIN_CLASS: 4.1.2.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2494 ) or ( H16_A1235 ) or ( H16_A1547 ) or ( H16_A0186 ) or ( H16_A2385 )

+

PROTEIN_ASSOCIATION: ( H16_B2494 ) or ( H16_A1235 ) or ( H16_A1547 ) or ( H16_A0186 ) or ( H16_A2385 )

+

SUBSYSTEM: Butanoate metabolism

+

PROTEIN_CLASS: 4.1.3.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2343 ) or ( H16_A3263 )

+

PROTEIN_ASSOCIATION: ( H16_A2343 ) or ( H16_A3263 )

+

SUBSYSTEM: Urea Cycle and Metabolism of amino groups

+

PROTEIN_CLASS: 2.3.1.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2135 ) or ( H16_B0495 ) or ( H16_A1145 ) or ( H16_B1480 )

+

PROTEIN_ASSOCIATION: ( H16_B2135 ) or ( H16_B0495 ) or ( H16_A1145 ) or ( H16_B1480 )

+

SUBSYSTEM: 1,4-Dichlorobenzene degradation

+

PROTEIN_CLASS: 1.14.13.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2135 ) or ( H16_B0495 ) or ( H16_A1145 ) or ( H16_B1480 )

+

PROTEIN_ASSOCIATION: ( H16_B2135 ) or ( H16_B0495 ) or ( H16_A1145 ) or ( H16_B1480 )

+

SUBSYSTEM: 1,4-Dichlorobenzene degradation

+

PROTEIN_CLASS: 1.14.13.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0356 ) or ( H16_A3321 )

+

PROTEIN_ASSOCIATION: ( H16_A0356 ) or ( H16_A3321 )

+

SUBSYSTEM: Phenylalanine, Tyrosine and Tryptophan biosynthesis

+

PROTEIN_CLASS: 2.4.2.18

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1786 ) or ( H16_B0970 )

+

PROTEIN_ASSOCIATION: ( H16_A1786 ) or ( H16_B0970 )

+

SUBSYSTEM: Benzoate degradation via Hydroxylation

+

PROTEIN_CLASS: 1.3.1.32

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2135 ) or ( H16_B0495 ) or ( H16_A1145 ) or ( H16_B1480 )

+

PROTEIN_ASSOCIATION: ( H16_B2135 ) or ( H16_B0495 ) or ( H16_A1145 ) or ( H16_B1480 )

+

SUBSYSTEM: Naphthalene and Anthracene degradation

+

PROTEIN_CLASS: 1.14.13.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2135 ) or ( H16_B0495 ) or ( H16_A1145 ) or ( H16_B1480 )

+

PROTEIN_ASSOCIATION: ( H16_B2135 ) or ( H16_B0495 ) or ( H16_A1145 ) or ( H16_B1480 )

+

SUBSYSTEM: Naphthalene and Anthracene degradation

+

PROTEIN_CLASS: 1.14.13.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2135 ) or ( H16_B0495 ) or ( H16_A1145 ) or ( H16_B1480 )

+

PROTEIN_ASSOCIATION: ( H16_B2135 ) or ( H16_B0495 ) or ( H16_A1145 ) or ( H16_B1480 )

+

SUBSYSTEM: Naphthalene and Anthracene degradation

+

PROTEIN_CLASS: 1.14.13.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2135 ) or ( H16_B0495 ) or ( H16_A1145 ) or ( H16_B1480 )

+

PROTEIN_ASSOCIATION: ( H16_B2135 ) or ( H16_B0495 ) or ( H16_A1145 ) or ( H16_B1480 )

+

SUBSYSTEM: Naphthalene and Anthracene degradation

+

PROTEIN_CLASS: 1.14.13.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Putative Transporters

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2802 )

+

PROTEIN_ASSOCIATION: ( H16_A2802 )

+

SUBSYSTEM: Vitamine B6 metabolism

+

PROTEIN_CLASS: 1.4.3.5

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B2073 ) or ( H16_B1014 ) or ( H16_A2862 ) or ( H16_B2401 ) or ( H16_B0339 ) or ( H16_A1150 )

+

PROTEIN_ASSOCIATION: ( H16_B2073 ) or ( H16_B1014 ) or ( H16_A2862 ) or ( H16_B2401 ) or ( H16_B0339 ) or ( H16_A1150 )

+

SUBSYSTEM: Butanoate metabolism

+

PROTEIN_CLASS: 3.1.1.75

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2507 ) or ( H16_B1199 )

+

PROTEIN_ASSOCIATION: ( H16_A2507 ) or ( H16_B1199 )

+

SUBSYSTEM: Glycerolipid Metabolism

+

PROTEIN_CLASS: 2.7.1.30

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A0336 )

+

PROTEIN_ASSOCIATION: ( H16_A0336 )

+

SUBSYSTEM: Glycerophospholipid Metabolism

+

PROTEIN_CLASS: 1.1.1.94

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1198 ) or ( H16_A2508 )

+

PROTEIN_ASSOCIATION: ( H16_B1198 ) or ( H16_A2508 )

+

SUBSYSTEM: Oxidative Phosphorylation

+

PROTEIN_CLASS: 1.1.99.5

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B0127 )

+

PROTEIN_ASSOCIATION: ( H16_B0127 )

+

SUBSYSTEM: Ascorbate and Aldarate metabolism

+

PROTEIN_CLASS: 4.2.1.40

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2129 ) or ( H16_B0738 ) or ( H16_B0730 )

+

PROTEIN_ASSOCIATION: ( H16_B2129 ) or ( H16_B0738 ) or ( H16_B0730 )

+

SUBSYSTEM: gamma-Hexachlorocyclohexane degradation

+

PROTEIN_CLASS: 1.14.-.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1691 ) or ( H16_B1690 ) or ( H16_A3190 ) or ( H16_B1864 )

+

PROTEIN_ASSOCIATION: ( H16_B1691 ) or ( H16_B1690 ) or ( H16_A3190 ) or ( H16_B1864 )

+

SUBSYSTEM: Benzoate degradation via CoA ligation

+

PROTEIN_CLASS: 3.1.2.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1692 )

+

PROTEIN_ASSOCIATION: ( H16_B1692 )

+

SUBSYSTEM: Glycine, Serine and threonine Metabolism

+

PROTEIN_CLASS: 2.6.1.76

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A1502 ) or ( H16_B1502 )

+

PROTEIN_ASSOCIATION: ( H16_A1502 ) or ( H16_B1502 )

+

SUBSYSTEM: Glycolysis/Gluconeogenesis

+

PROTEIN_CLASS: 5.3.1.9

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2265 )

+

PROTEIN_ASSOCIATION: ( H16_A2265 )

+

SUBSYSTEM: Vitamine B6 metabolism

+

PROTEIN_CLASS: 4.2.3.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A0566 ) or ( H16_B1385 )

+

PROTEIN_ASSOCIATION: ( H16_A0566 ) or ( H16_B1385 )

+

SUBSYSTEM: Glycolysis/Gluconeogenesis

+

PROTEIN_CLASS: 2.7.2.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A0332 ) or ( H16_A0493 )

+

PROTEIN_ASSOCIATION: ( H16_A0332 ) or ( H16_A0493 )

+

SUBSYSTEM: Glycolysis/Gluconeogenesis

+

PROTEIN_CLASS: 5.4.2.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2565 )

+

PROTEIN_ASSOCIATION: ( H16_B2565 )

+

SUBSYSTEM: Pentose Phosphate Pathway

+

PROTEIN_CLASS: 3.1.1.31

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0127 )

+

PROTEIN_ASSOCIATION: ( H16_B0127 )

+

SUBSYSTEM: Ascorbate and Aldarate metabolism

+

PROTEIN_CLASS: 4.2.1.40

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2589 )

+

PROTEIN_ASSOCIATION: ( H16_A2589 )

+

SUBSYSTEM: Nicotinate and Nicotinamide metabolism

+

PROTEIN_CLASS: 2.4.2.11

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0044 )

+

PROTEIN_ASSOCIATION: ( H16_A0044 )

+

SUBSYSTEM: Urea Cycle and Metabolism of amino groups

+

PROTEIN_CLASS: 3.5.3.11

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B0536 ) or ( H16_A1966 )

+

PROTEIN_ASSOCIATION: ( H16_B0536 ) or ( H16_A1966 )

+

SUBSYSTEM: Benzoate degradation via Hydroxylation

+

PROTEIN_CLASS: 5.5.1.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0536 ) or ( H16_A1966 )

+

PROTEIN_ASSOCIATION: ( H16_B0536 ) or ( H16_A1966 )

+

SUBSYSTEM: 1,4-Dichlorobenzene degradation

+

PROTEIN_CLASS: 5.5.1.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0536 ) or ( H16_A1966 )

+

PROTEIN_ASSOCIATION: ( H16_B0536 ) or ( H16_A1966 )

+

SUBSYSTEM: Fluorobenzoate degradation

+

PROTEIN_CLASS: 5.5.1.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0536 ) or ( H16_A1966 )

+

PROTEIN_ASSOCIATION: ( H16_B0536 ) or ( H16_A1966 )

+

SUBSYSTEM: Benzoate degradation via Hydroxylation

+

PROTEIN_CLASS: 5.5.1.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0504 )

+

PROTEIN_ASSOCIATION: ( H16_A0504 )

+

SUBSYSTEM: Ubiquinone Biosynthesis

+

PROTEIN_CLASS: 1.14.13.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1789 )

+

PROTEIN_ASSOCIATION: ( H16_A1789 )

+

SUBSYSTEM: Trinitrotoluene degradation

+

PROTEIN_CLASS: 1.-.-.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0235 )

+

PROTEIN_ASSOCIATION: ( H16_A0235 )

+

SUBSYSTEM: Thiamine Metabolism

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0504 )

+

PROTEIN_ASSOCIATION: ( H16_A0504 )

+

SUBSYSTEM: Ubiquinone Biosynthesis

+

PROTEIN_CLASS: 1.14.13.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0536 ) or ( H16_A1966 )

+

PROTEIN_ASSOCIATION: ( H16_B0536 ) or ( H16_A1966 )

+

SUBSYSTEM: Toluene and Xylene degradation

+

PROTEIN_CLASS: 5.5.1.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0504 )

+

PROTEIN_ASSOCIATION: ( H16_A0504 )

+

SUBSYSTEM: Ubiquinone Biosynthesis

+

PROTEIN_CLASS: 1.14.13.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0831 )

+

PROTEIN_ASSOCIATION: ( H16_A0831 )

+

SUBSYSTEM: Tyrosine metabolism

+

PROTEIN_CLASS: 1.4.3.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3106 )

+

PROTEIN_ASSOCIATION: ( H16_A3106 )

+

SUBSYSTEM: Arginine and Proline metabolism

+

PROTEIN_CLASS: 1.5.1.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0274 ) or ( H16_B2255 ) or ( H16_A2179 ) or ( H16_A0517 ) or ( H16_B1143 )

+

PROTEIN_ASSOCIATION: ( H16_A0274 ) or ( H16_B2255 ) or ( H16_A2179 ) or ( H16_A0517 ) or ( H16_B1143 )

+

SUBSYSTEM: Pyruvate Metabolism

+

PROTEIN_CLASS: 4.4.1.5

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0831 )

+

PROTEIN_ASSOCIATION: ( H16_A0831 )

+

SUBSYSTEM: Phenylalanine metabolism

+

PROTEIN_CLASS: 1.4.3.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0322 )

+

PROTEIN_ASSOCIATION: ( H16_A0322 )

+

SUBSYSTEM: Glutamate metabolism

+

PROTEIN_CLASS: 6.3.2.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0831 )

+

PROTEIN_ASSOCIATION: ( H16_A0831 )

+

SUBSYSTEM: Tyrosine metabolism

+

PROTEIN_CLASS: 1.4.3.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0831 )

+

PROTEIN_ASSOCIATION: ( H16_A0831 )

+

SUBSYSTEM: Tyrosine metabolism

+

PROTEIN_CLASS: 1.4.3.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0831 )

+

PROTEIN_ASSOCIATION: ( H16_A0831 )

+

SUBSYSTEM: Tyrosine metabolism

+

PROTEIN_CLASS: 1.4.3.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3412 ) or ( H16_A3410 )

+

PROTEIN_ASSOCIATION: ( H16_A3412 ) or ( H16_A3410 )

+

SUBSYSTEM: Histidine Metabolism

+

PROTEIN_CLASS: 4.1.3.- 2.4.2.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0831 )

+

PROTEIN_ASSOCIATION: ( H16_A0831 )

+

SUBSYSTEM: Tyrosine metabolism

+

PROTEIN_CLASS: 1.4.3.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0831 )

+

PROTEIN_ASSOCIATION: ( H16_A0831 )

+

SUBSYSTEM: Glycine, Serine and threonine Metabolism

+

PROTEIN_CLASS: 1.4.3.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0831 )

+

PROTEIN_ASSOCIATION: ( H16_A0831 )

+

SUBSYSTEM: Histidine Metabolism

+

PROTEIN_CLASS: 1.4.3.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3273 )

+

PROTEIN_ASSOCIATION: ( H16_A3273 )

+

SUBSYSTEM: Peptidoglycan Biosynthesis

+

PROTEIN_CLASS: 2.4.1.227

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0831 )

+

PROTEIN_ASSOCIATION: ( H16_A0831 )

+

SUBSYSTEM: Tyrosine metabolism

+

PROTEIN_CLASS: 1.4.3.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3699 )

+

PROTEIN_ASSOCIATION: ( H16_A3699 )

+

SUBSYSTEM: Aminoacyl-tRNA Biosynthesis

+

PROTEIN_CLASS: 2.1.2.9

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1456 )

+

PROTEIN_ASSOCIATION: ( H16_A1456 )

+

SUBSYSTEM: Biosynthesis of steroids

+

PROTEIN_CLASS: 2.7.7.60

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0352 )

+

PROTEIN_ASSOCIATION: ( H16_A0352 )

+

SUBSYSTEM: Porphyrin and Chlorophyll metabolism

+

PROTEIN_CLASS: 2.5.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: 1,1,1-Trichloro-2,2-Bis-(Chlorophenyl)Ethane (DDT) degradation

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0734 ) or ( H16_B0731 )

+

PROTEIN_ASSOCIATION: ( H16_B0734 ) or ( H16_B0731 )

+

SUBSYSTEM: Fluorobenzoate degradation

+

PROTEIN_CLASS: 1.3.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B2421 )

+

PROTEIN_ASSOCIATION: ( H16_B2421 )

+

SUBSYSTEM: Alanine and Aspartate Metabolism

+

PROTEIN_CLASS: 5.1.1.13

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Lipopolysaccharide Biosynthesis

+

PROTEIN_CLASS: 5.-.-.-

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2552 ) or ( H16_A0513 ) or ( H16_B0319 ) or ( H16_B0216 )

+

PROTEIN_ASSOCIATION: ( H16_A2552 ) or ( H16_A0513 ) or ( H16_B0319 ) or ( H16_B0216 )

+

SUBSYSTEM: Vitamine B6 metabolism

+

PROTEIN_CLASS: 1.1.1.262 2.6.99.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0243 )

+

PROTEIN_ASSOCIATION: ( H16_A0243 )

+

SUBSYSTEM: Thiamine Metabolism

+

PROTEIN_CLASS: 2.7.1.49

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2987 ) or ( H16_B0280 )

+

PROTEIN_ASSOCIATION: ( H16_A2987 ) or ( H16_B0280 )

+

SUBSYSTEM: Valine, Leucine, and Isoleucine Metabolism

+

PROTEIN_CLASS: 4.2.1.9

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1139 )

+

PROTEIN_ASSOCIATION: ( H16_A1139 )

+

SUBSYSTEM: Glycerophospholipid Metabolism

+

PROTEIN_CLASS: 3.1.1.32

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2981 )

+

PROTEIN_ASSOCIATION: ( H16_A2981 )

+

SUBSYSTEM: Propanoate metabolism

+

PROTEIN_CLASS: 4.1.1.9

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2987 ) or ( H16_B0280 )

+

PROTEIN_ASSOCIATION: ( H16_A2987 ) or ( H16_B0280 )

+

SUBSYSTEM: Valine, Leucine, and Isoleucine Metabolism

+

PROTEIN_CLASS: 4.2.1.9

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2551 )

+

PROTEIN_ASSOCIATION: ( H16_A2551 )

+

SUBSYSTEM: Pantothenate and CoA biosynthesis

+

PROTEIN_CLASS: 2.7.8.7

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A3075 ) or ( H16_A0068 )

+

PROTEIN_ASSOCIATION: ( H16_A3075 ) or ( H16_A0068 )

+

SUBSYSTEM: Pyrimidine metabolism

+

PROTEIN_CLASS: 3.5.2.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2718 )

+

PROTEIN_ASSOCIATION: ( H16_A2718 )

+

SUBSYSTEM: Styrene degradation

+

PROTEIN_CLASS: 2.8.3.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2718 )

+

PROTEIN_ASSOCIATION: ( H16_A2718 )

+

SUBSYSTEM: Propanoate metabolism

+

PROTEIN_CLASS: 2.8.3.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Glycolysis/Gluconeogenesis

+

PROTEIN_CLASS: 5.4.2.2

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2718 )

+

PROTEIN_ASSOCIATION: ( H16_A2718 )

+

SUBSYSTEM: Pyruvate Metabolism

+

PROTEIN_CLASS: 2.8.3.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A0227 )

+

PROTEIN_ASSOCIATION: ( H16_A0227 )

+

SUBSYSTEM: Lysine Biosynthesis

+

PROTEIN_CLASS: 5.1.1.7

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2368 )

+

PROTEIN_ASSOCIATION: ( H16_A2368 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 2.7.4.6

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0236 )

+

PROTEIN_ASSOCIATION: ( H16_A0236 )

+

SUBSYSTEM: Thiamine Metabolism

+

PROTEIN_CLASS: 1.4.3.19

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2607 )

+

PROTEIN_ASSOCIATION: ( H16_A2607 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 2.4.2.14

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2130 )

+

PROTEIN_ASSOCIATION: ( H16_B2130 )

+

SUBSYSTEM: Glycine, Serine and threonine Metabolism

+

PROTEIN_CLASS: 1.2.1.8

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2130 )

+

PROTEIN_ASSOCIATION: ( H16_B2130 )

+

SUBSYSTEM: Glycine, Serine and threonine Metabolism

+

PROTEIN_CLASS: 1.2.1.8

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0477 )

+

PROTEIN_ASSOCIATION: ( H16_A0477 )

+

SUBSYSTEM: Butanoate metabolism

+

PROTEIN_CLASS: 1.1.1.83

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A0561 )

+

PROTEIN_ASSOCIATION: ( H16_A0561 )

+

SUBSYSTEM: Valine, Leucine, and Isoleucine Metabolism

+

PROTEIN_CLASS: 2.6.1.42

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3223 )

+

PROTEIN_ASSOCIATION: ( H16_A3223 )

+

SUBSYSTEM: Alanine and Aspartate Metabolism

+

PROTEIN_CLASS: 6.3.5.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1374 ) or ( H16_B1300 ) or ( H16_B0145 ) or ( H16_B2234 ) or ( H16_B2233 ) or ( H16_A1753 )

+

PROTEIN_ASSOCIATION: ( H16_A1374 ) or ( H16_B1300 ) or ( H16_B0145 ) or ( H16_B2234 ) or ( H16_B2233 ) or ( H16_A1753 )

+

SUBSYSTEM: Glycolysis/Gluconeogenesis

+

PROTEIN_CLASS: 1.2.4.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2457 )

+

PROTEIN_ASSOCIATION: ( H16_A2457 )

+

SUBSYSTEM: Carbazole degradation

+

PROTEIN_CLASS: 6.2.1.32

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B1016 )

+

PROTEIN_ASSOCIATION: ( H16_B1016 )

+

SUBSYSTEM: Citric Acid Cycle

+

PROTEIN_CLASS: 1.1.1.41

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1375 ) or ( H16_B0146 )

+

PROTEIN_ASSOCIATION: ( H16_A1375 ) or ( H16_B0146 )

+

SUBSYSTEM: Glycolysis/Gluconeogenesis

+

PROTEIN_CLASS: 2.3.1.12

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B1255 ) or ( H16_A0458 )

+

PROTEIN_ASSOCIATION: ( H16_B1255 ) or ( H16_A0458 )

+

SUBSYSTEM: Glycerophospholipid Metabolism

+

PROTEIN_CLASS: 2.7.8.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1255 ) or ( H16_A0458 )

+

PROTEIN_ASSOCIATION: ( H16_B1255 ) or ( H16_A0458 )

+

SUBSYSTEM: Glycerophospholipid Metabolism

+

PROTEIN_CLASS: 2.7.8.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3631 )

+

PROTEIN_ASSOCIATION: ( H16_A3631 )

+

SUBSYSTEM: Arginine and Proline Metabolism

+

PROTEIN_CLASS: 1.5.1.12

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0654 )

+

PROTEIN_ASSOCIATION: ( H16_B0654 )

+

SUBSYSTEM: gamma-Hexachlorocyclohexane degradation

+

PROTEIN_CLASS: 1.13.11.39

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3631 )

+

PROTEIN_ASSOCIATION: ( H16_A3631 )

+

SUBSYSTEM: Arginine and Proline Metabolism

+

PROTEIN_CLASS: 1.5.1.12

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0230 ) or ( H16_A1975 )

+

PROTEIN_ASSOCIATION: ( H16_A0230 ) or ( H16_A1975 )

+

SUBSYSTEM: Methionine Metabolism

+

PROTEIN_CLASS: 2.5.1.6

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3724 ) or ( H16_A2323 ) or ( H16_A1377 ) or ( H16_B1098 )

+

PROTEIN_ASSOCIATION: ( H16_A3724 ) or ( H16_A2323 ) or ( H16_A1377 ) or ( H16_B1098 )

+

SUBSYSTEM: Glycolysis/Gluconeogenesis

+

PROTEIN_CLASS: 1.8.1.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A3631 )

+

PROTEIN_ASSOCIATION: ( H16_A3631 )

+

SUBSYSTEM: Arginine and Proline Metabolism

+

PROTEIN_CLASS: 1.5.1.12

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0734 ) or ( H16_B0731 )

+

PROTEIN_ASSOCIATION: ( H16_B0734 ) or ( H16_B0731 )

+

SUBSYSTEM: Tryptophan metabolism

+

PROTEIN_CLASS: 1.3.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B0734 ) or ( H16_B0731 )

+

PROTEIN_ASSOCIATION: ( H16_B0734 ) or ( H16_B0731 )

+

SUBSYSTEM: Propanoate metabolism

+

PROTEIN_CLASS: 1.3.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2446 )

+

PROTEIN_ASSOCIATION: ( H16_B2446 )

+

SUBSYSTEM: Benzoate degradation via CoA ligation

+

PROTEIN_CLASS: 4.1.1.61

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1291 )

+

PROTEIN_ASSOCIATION: ( H16_B1291 )

+

SUBSYSTEM: Pentose Phosphate Pathway

+

PROTEIN_CLASS: 2.7.4.23

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A1225 )

+

PROTEIN_ASSOCIATION: ( H16_A1225 )

+

SUBSYSTEM: Glycine, Serine and threonine Metabolism

+

PROTEIN_CLASS: 2.7.2.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0932 )

+

PROTEIN_ASSOCIATION: ( H16_A0932 )

+

SUBSYSTEM: Pyruvate Metabolism

+

PROTEIN_CLASS: 4.2.3.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2456 ) or ( H16_A1529 )

+

PROTEIN_ASSOCIATION: ( H16_A2456 ) or ( H16_A1529 )

+

SUBSYSTEM: 2,4-Dichlorobenzoate degradation

+

PROTEIN_CLASS: 3.1.2.23

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2997 )

+

PROTEIN_ASSOCIATION: ( H16_A2997 )

+

SUBSYSTEM: Sulfur Metabolism

+

PROTEIN_CLASS: 1.8.4.8

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0477 ) or ( H16_A2619 ) or ( H16_A2133 )

+

PROTEIN_ASSOCIATION: ( H16_A0477 ) or ( H16_A2619 ) or ( H16_A2133 )

+

SUBSYSTEM: Valine, Leucine and Isoleucine degradation

+

PROTEIN_CLASS: 1.1.1.85

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2997 )

+

PROTEIN_ASSOCIATION: ( H16_A2997 )

+

SUBSYSTEM: Sulfur Metabolism

+

PROTEIN_CLASS: 1.8.4.8

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Glyoxylate and Dicarboxylate metabolism

+

PROTEIN_CLASS: 1.2.1.21

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2802 )

+

PROTEIN_ASSOCIATION: ( H16_A2802 )

+

SUBSYSTEM: Vitamine B6 metabolism

+

PROTEIN_CLASS: 1.4.3.5

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1109 ) or ( H16_A3649 ) or ( H16_A1306 ) or ( H16_A3013 )

+

PROTEIN_ASSOCIATION: ( H16_A1109 ) or ( H16_A3649 ) or ( H16_A1306 ) or ( H16_A3013 )

+

SUBSYSTEM: Glyoxylate and Dicarboxylate metabolism

+

PROTEIN_CLASS: 3.5.1.68

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2078 ) or ( H16_B2438 )

+

PROTEIN_ASSOCIATION: ( H16_A2078 ) or ( H16_B2438 )

+

SUBSYSTEM: Oxidative Phosphorylation

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2265 ) or ( H16_B2268 ) or ( H16_B2267 ) or ( H16_B2266 ) or ( H16_B0776 )

+

PROTEIN_ASSOCIATION: ( H16_B2265 ) or ( H16_B2268 ) or ( H16_B2267 ) or ( H16_B2266 ) or ( H16_B0776 )

+

SUBSYSTEM: Nitrogen Metabolism

+

PROTEIN_CLASS: 1.7.99.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0671 ) or ( H16_A2352 )

+

PROTEIN_ASSOCIATION: ( H16_B0671 ) or ( H16_A2352 )

+

SUBSYSTEM: Rivoflavin metabolism

+

PROTEIN_CLASS: 1.5.1.30

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0546 )

+

PROTEIN_ASSOCIATION: ( H16_B0546 )

+

SUBSYSTEM: Toluene and Xylene degradation

+

PROTEIN_CLASS: 1.13.11.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0546 )

+

PROTEIN_ASSOCIATION: ( H16_B0546 )

+

SUBSYSTEM: Toluene and Xylene degradation

+

PROTEIN_CLASS: 1.13.11.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0546 )

+

PROTEIN_ASSOCIATION: ( H16_B0546 )

+

SUBSYSTEM: Styrene degradation

+

PROTEIN_CLASS: 1.13.11.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0546 )

+

PROTEIN_ASSOCIATION: ( H16_B0546 )

+

SUBSYSTEM: 1,4-Dichlorobenzene degradation

+

PROTEIN_CLASS: 1.13.11.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0546 )

+

PROTEIN_ASSOCIATION: ( H16_B0546 )

+

SUBSYSTEM: Benzoate degradation via Hydroxylation

+

PROTEIN_CLASS: 1.13.11.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A0211 )

+

PROTEIN_ASSOCIATION: ( H16_A0211 )

+

SUBSYSTEM: Methionine Metabolism

+

PROTEIN_CLASS: 2.3.1.31

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3154 )

+

PROTEIN_ASSOCIATION: ( H16_A3154 )

+

SUBSYSTEM: Thiamine Metabolism

+

PROTEIN_CLASS: 2.7.4.16

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2266 )

+

PROTEIN_ASSOCIATION: ( H16_A2266 )

+

SUBSYSTEM: Glycine, Serine and threonine Metabolism

+

PROTEIN_CLASS: 1.1.1.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0259 )

+

PROTEIN_ASSOCIATION: ( H16_A0259 )

+

SUBSYSTEM: Folate Biosynthesis

+

PROTEIN_CLASS: 4.1.2.25

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1457 )

+

PROTEIN_ASSOCIATION: ( H16_A1457 )

+

SUBSYSTEM: Biosynthesis of steroids

+

PROTEIN_CLASS: 4.6.1.12

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2191 ) or ( H16_B0618 ) or ( H16_A2335 )

+

PROTEIN_ASSOCIATION: ( H16_B2191 ) or ( H16_B0618 ) or ( H16_A2335 )

+

SUBSYSTEM: Glutamate metabolism

+

PROTEIN_CLASS: 6.3.1.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2191 ) or ( H16_B0618 ) or ( H16_A2335 )

+

PROTEIN_ASSOCIATION: ( H16_B2191 ) or ( H16_B0618 ) or ( H16_A2335 )

+

SUBSYSTEM: Peptidoglycan Biosynthesis

+

PROTEIN_CLASS: 6.3.1.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2434 ) or ( H16_A0520 ) or ( H16_B0594 ) or ( H16_B1063 ) or ( H16_A0786 ) or ( H16_A2577 ) or ( H16_B2398 )

+

PROTEIN_ASSOCIATION: ( H16_A2434 ) or ( H16_A0520 ) or ( H16_B0594 ) or ( H16_B1063 ) or ( H16_A0786 ) or ( H16_A2577 ) or ( H16_B2398 )

+

SUBSYSTEM: Thiamine Metabolism

+

PROTEIN_CLASS: 3.1.3.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2078 ) or ( H16_B2438 )

+

PROTEIN_ASSOCIATION: ( H16_A2078 ) or ( H16_B2438 )

+

SUBSYSTEM: Oxidative Phosphorylation

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0847 ) or ( H16_B0367 ) or ( H16_B0655 ) or ( H16_B0656 ) or ( H16_B0914 ) or ( H16_B0355 ) or ( H16_B0488 )

+

PROTEIN_ASSOCIATION: ( H16_B0847 ) or ( H16_B0367 ) or ( H16_B0655 ) or ( H16_B0656 ) or ( H16_B0914 ) or ( H16_B0355 ) or ( H16_B0488 )

+

SUBSYSTEM: 1- and 2-Methylnaphthalene degradation

+

PROTEIN_CLASS: 2.8.3.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A0548 ) or ( H16_A0547 )

+

PROTEIN_ASSOCIATION: ( H16_A0548 ) or ( H16_A0547 )

+

SUBSYSTEM: C5-Branched Dibasic acid metabolism

+

PROTEIN_CLASS: 6.2.1.5

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3631 )

+

PROTEIN_ASSOCIATION: ( H16_A3631 )

+

SUBSYSTEM: Arginine and Proline Metabolism

+

PROTEIN_CLASS: 1.5.1.12

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0666 )

+

PROTEIN_ASSOCIATION: ( H16_A0666 )

+

SUBSYSTEM: Cysteine Metabolism

+

PROTEIN_CLASS: 1.1.1.27

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2102 )

+

PROTEIN_ASSOCIATION: ( H16_A2102 )

+

SUBSYSTEM: Alanine and Aspartate Metabolism

+

PROTEIN_CLASS: 3.5.1.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0666 )

+

PROTEIN_ASSOCIATION: ( H16_A0666 )

+

SUBSYSTEM: Propanoate metabolism

+

PROTEIN_CLASS: 1.1.1.27

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2215 ) or ( H16_A3488 ) or ( H16_A2739 )

+

PROTEIN_ASSOCIATION: ( H16_A2215 ) or ( H16_A3488 ) or ( H16_A2739 )

+

SUBSYSTEM: gamma-Hexachlorocyclohexane degradation

+

PROTEIN_CLASS: 3.1.1.45

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2215 ) or ( H16_A3488 ) or ( H16_A2739 )

+

PROTEIN_ASSOCIATION: ( H16_A2215 ) or ( H16_A3488 ) or ( H16_A2739 )

+

SUBSYSTEM: gamma-Hexachlorocyclohexane degradation

+

PROTEIN_CLASS: 3.1.1.45

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0612 )

+

PROTEIN_ASSOCIATION: ( H16_B0612 )

+

SUBSYSTEM: Glycine, Serine and threonine Metabolism

+

PROTEIN_CLASS: 2.7.1.31

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3533 )

+

PROTEIN_ASSOCIATION: ( H16_A3533 )

+

SUBSYSTEM: Nitrogen Metabolism

+

PROTEIN_CLASS: 1.14.12.17

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2215 ) or ( H16_A3488 ) or ( H16_A2739 )

+

PROTEIN_ASSOCIATION: ( H16_A2215 ) or ( H16_A3488 ) or ( H16_A2739 )

+

SUBSYSTEM: Fluorobenzoate degradation

+

PROTEIN_CLASS: 3.1.1.45

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A0224 )

+

PROTEIN_ASSOCIATION: ( H16_A0224 )

+

SUBSYSTEM: Pyrimidine metabolism

+

PROTEIN_CLASS: 2.4.2.10

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3533 )

+

PROTEIN_ASSOCIATION: ( H16_A3533 )

+

SUBSYSTEM: Nitrogen Metabolism

+

PROTEIN_CLASS: 1.14.12.17

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0612 )

+

PROTEIN_ASSOCIATION: ( H16_B0612 )

+

SUBSYSTEM: Glyoxylate and Dicarboxylate metabolism

+

PROTEIN_CLASS: 2.7.1.31

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3212 ) or ( H16_A3222 ) or ( H16_A2744 ) or ( H16_A3213 )

+

PROTEIN_ASSOCIATION: ( H16_A3212 ) or ( H16_A3222 ) or ( H16_A2744 ) or ( H16_A3213 )

+

SUBSYSTEM: Glycine, Serine and threonine Metabolism

+

PROTEIN_CLASS: 2.7.1.39

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2215 ) or ( H16_A3488 ) or ( H16_A2739 )

+

PROTEIN_ASSOCIATION: ( H16_A2215 ) or ( H16_A3488 ) or ( H16_A2739 )

+

SUBSYSTEM: 1,4-Dichlorobenzene degradation

+

PROTEIN_CLASS: 3.1.1.45

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2215 ) or ( H16_A3488 ) or ( H16_A2739 )

+

PROTEIN_ASSOCIATION: ( H16_A2215 ) or ( H16_A3488 ) or ( H16_A2739 )

+

SUBSYSTEM: 1,4-Dichlorobenzene degradation

+

PROTEIN_CLASS: 3.1.1.45

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2215 ) or ( H16_A3488 ) or ( H16_A2739 )

+

PROTEIN_ASSOCIATION: ( H16_A2215 ) or ( H16_A3488 ) or ( H16_A2739 )

+

SUBSYSTEM: 1,4-Dichlorobenzene degradation

+

PROTEIN_CLASS: 3.1.1.45

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0295 )

+

PROTEIN_ASSOCIATION: ( H16_B0295 )

+

SUBSYSTEM: Selenoamino acid metabolism

+

PROTEIN_CLASS: 2.7.9.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2215 ) or ( H16_A3488 ) or ( H16_A2739 )

+

PROTEIN_ASSOCIATION: ( H16_A2215 ) or ( H16_A3488 ) or ( H16_A2739 )

+

SUBSYSTEM: Fluorobenzoate degradation

+

PROTEIN_CLASS: 3.1.1.45

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2135 ) or ( H16_B0495 ) or ( H16_A1145 ) or ( H16_B1480 )

+

PROTEIN_ASSOCIATION: ( H16_B2135 ) or ( H16_B0495 ) or ( H16_A1145 ) or ( H16_B1480 )

+

SUBSYSTEM: 1- and 2-Methylnaphthalene degradation

+

PROTEIN_CLASS: 1.14.13.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0677 ) or ( H16_B2522 ) or ( H16_B1709 ) or ( H16_A1700 ) or ( H16_A2794 ) or ( H16_A2252 ) or ( H16_A2807 ) or ( H16_A1718 ) or ( H16_A0866 ) or ( H16_A0871 ) or ( H16_A1230 ) or ( H16_B0174 ) or ( H16_A1519 ) or ( H16_B1335 ) or ( H16_B0910 ) or ( H16_B1264 ) or ( H16_B1148 ) or ( H16_B1662 ) or ( H16_A2978 )

+

PROTEIN_ASSOCIATION: ( H16_B0677 ) or ( H16_B2522 ) or ( H16_B1709 ) or ( H16_A1700 ) or ( H16_A2794 ) or ( H16_A2252 ) or ( H16_A2807 ) or ( H16_A1718 ) or ( H16_A0866 ) or ( H16_A0871 ) or ( H16_A1230 ) or ( H16_B0174 ) or ( H16_A1519 ) or ( H16_B1335 ) or ( H16_B0910 ) or ( H16_B1264 ) or ( H16_B1148 ) or ( H16_B1662 ) or ( H16_A2978 )

+

SUBSYSTEM: Geraniol degrdation

+

PROTEIN_CLASS: 6.2.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0219 ) or ( H16_B2397 ) or ( H16_B1899 ) or ( H16_A3529 ) or ( H16_B0018 ) or ( H16_A0269 ) or ( H16_A1564 ) or ( H16_A1683 ) or ( H16_A0699 ) or ( H16_B1278 ) or ( H16_A3586 ) or ( H16_B1407 ) or ( H16_A0240 ) or ( H16_A3093 ) or ( H16_A0039 ) or ( H16_A1802 ) or ( H16_A1315 ) or ( H16_B1292 ) or ( H16_A3221 ) or ( H16_B0032 ) or ( H16_B1663 ) or ( H16_A2759 ) or ( H16_A3071 ) or ( H16_B0021 )

+

PROTEIN_ASSOCIATION: ( H16_B0219 ) or ( H16_B2397 ) or ( H16_B1899 ) or ( H16_A3529 ) or ( H16_B0018 ) or ( H16_A0269 ) or ( H16_A1564 ) or ( H16_A1683 ) or ( H16_A0699 ) or ( H16_B1278 ) or ( H16_A3586 ) or ( H16_B1407 ) or ( H16_A0240 ) or ( H16_A3093 ) or ( H16_A0039 ) or ( H16_A1802 ) or ( H16_A1315 ) or ( H16_B1292 ) or ( H16_A3221 ) or ( H16_B0032 ) or ( H16_B1663 ) or ( H16_A2759 ) or ( H16_A3071 ) or ( H16_B0021 )

+

SUBSYSTEM: Tyrosine metabolism

+

PROTEIN_CLASS: 2.3.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0219 ) or ( H16_B2397 ) or ( H16_B1899 ) or ( H16_A3529 ) or ( H16_B0018 ) or ( H16_A0269 ) or ( H16_A1564 ) or ( H16_A1683 ) or ( H16_A0699 ) or ( H16_B1278 ) or ( H16_A3586 ) or ( H16_B1407 ) or ( H16_A0240 ) or ( H16_A3093 ) or ( H16_A0039 ) or ( H16_A1802 ) or ( H16_A1315 ) or ( H16_B1292 ) or ( H16_A3221 ) or ( H16_B0032 ) or ( H16_B1663 ) or ( H16_A2759 ) or ( H16_A3071 ) or ( H16_B0021 )

+

PROTEIN_ASSOCIATION: ( H16_B0219 ) or ( H16_B2397 ) or ( H16_B1899 ) or ( H16_A3529 ) or ( H16_B0018 ) or ( H16_A0269 ) or ( H16_A1564 ) or ( H16_A1683 ) or ( H16_A0699 ) or ( H16_B1278 ) or ( H16_A3586 ) or ( H16_B1407 ) or ( H16_A0240 ) or ( H16_A3093 ) or ( H16_A0039 ) or ( H16_A1802 ) or ( H16_A1315 ) or ( H16_B1292 ) or ( H16_A3221 ) or ( H16_B0032 ) or ( H16_B1663 ) or ( H16_A2759 ) or ( H16_A3071 ) or ( H16_B0021 )

+

SUBSYSTEM: Phenylalanine metabolism

+

PROTEIN_CLASS: 2.3.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0546 )

+

PROTEIN_ASSOCIATION: ( H16_B0546 )

+

SUBSYSTEM: Benzoate degradation via Hydroxylation

+

PROTEIN_CLASS: 1.13.11.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0219 ) or ( H16_B2397 ) or ( H16_B1899 ) or ( H16_A3529 ) or ( H16_B0018 ) or ( H16_A0269 ) or ( H16_A1564 ) or ( H16_A1683 ) or ( H16_A0699 ) or ( H16_B1278 ) or ( H16_A3586 ) or ( H16_B1407 ) or ( H16_A0240 ) or ( H16_A3093 ) or ( H16_A0039 ) or ( H16_A1802 ) or ( H16_A1315 ) or ( H16_B1292 ) or ( H16_A3221 ) or ( H16_B0032 ) or ( H16_B1663 ) or ( H16_A2759 ) or ( H16_A3071 ) or ( H16_B0021 )

+

PROTEIN_ASSOCIATION: ( H16_B0219 ) or ( H16_B2397 ) or ( H16_B1899 ) or ( H16_A3529 ) or ( H16_B0018 ) or ( H16_A0269 ) or ( H16_A1564 ) or ( H16_A1683 ) or ( H16_A0699 ) or ( H16_B1278 ) or ( H16_A3586 ) or ( H16_B1407 ) or ( H16_A0240 ) or ( H16_A3093 ) or ( H16_A0039 ) or ( H16_A1802 ) or ( H16_A1315 ) or ( H16_B1292 ) or ( H16_A3221 ) or ( H16_B0032 ) or ( H16_B1663 ) or ( H16_A2759 ) or ( H16_A3071 ) or ( H16_B0021 )

+

SUBSYSTEM: Benzoate degradation via CoA ligation

+

PROTEIN_CLASS: 2.3.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0219 ) or ( H16_B2397 ) or ( H16_B1899 ) or ( H16_A3529 ) or ( H16_B0018 ) or ( H16_A0269 ) or ( H16_A1564 ) or ( H16_A1683 ) or ( H16_A0699 ) or ( H16_B1278 ) or ( H16_A3586 ) or ( H16_B1407 ) or ( H16_A0240 ) or ( H16_A3093 ) or ( H16_A0039 ) or ( H16_A1802 ) or ( H16_A1315 ) or ( H16_B1292 ) or ( H16_A3221 ) or ( H16_B0032 ) or ( H16_B1663 ) or ( H16_A2759 ) or ( H16_A3071 ) or ( H16_B0021 )

+

PROTEIN_ASSOCIATION: ( H16_B0219 ) or ( H16_B2397 ) or ( H16_B1899 ) or ( H16_A3529 ) or ( H16_B0018 ) or ( H16_A0269 ) or ( H16_A1564 ) or ( H16_A1683 ) or ( H16_A0699 ) or ( H16_B1278 ) or ( H16_A3586 ) or ( H16_B1407 ) or ( H16_A0240 ) or ( H16_A3093 ) or ( H16_A0039 ) or ( H16_A1802 ) or ( H16_A1315 ) or ( H16_B1292 ) or ( H16_A3221 ) or ( H16_B0032 ) or ( H16_B1663 ) or ( H16_A2759 ) or ( H16_A3071 ) or ( H16_B0021 )

+

SUBSYSTEM: Benzoate degradation via CoA ligation

+

PROTEIN_CLASS: 2.3.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A0100 ) or ( H16_A3311 ) or ( H16_B1738 ) or ( H16_B0402 ) or ( H16_A3593 ) or ( H16_A1101 ) or ( H16_A0865 ) or ( H16_B1188 ) or ( H16_A3594 ) or ( H16_B0756 ) or ( H16_A1885 ) or ( H16_A3201 ) or ( H16_A2979 ) or ( H16_A1889 ) or ( H16_B0915 ) or ( H16_A1410 ) or ( H16_A0179 ) or ( H16_A0142 ) or ( H16_B1905 ) or ( H16_B1741 ) or ( H16_B1742 ) or ( H16_B0419 ) or ( H16_A0810 ) or ( H16_A0461 ) or ( H16_B1439 ) or ( H16_B0848 ) or ( H16_B0659 ) or ( H16_A1719 ) or ( H16_B2478 ) or ( H16_A0873 ) or ( H16_B2156 ) or ( H16_B0657 ) or ( H16_B0389 ) or ( H16_B1346 ) or ( H16_B0698 ) or ( H16_A1716 ) or ( H16_B0420 ) or ( H16_A2138 ) or ( H16_B0365 ) or ( H16_B0382 ) or ( H16_A1832 ) or ( H16_A2258 ) or ( H16_B0724 ) or ( H16_B1914 ) or ( H16_B1773 ) or ( H16_A0464 ) or ( H16_A1699 )

+

PROTEIN_ASSOCIATION: ( H16_A0100 ) or ( H16_A3311 ) or ( H16_B1738 ) or ( H16_B0402 ) or ( H16_A3593 ) or ( H16_A1101 ) or ( H16_A0865 ) or ( H16_B1188 ) or ( H16_A3594 ) or ( H16_B0756 ) or ( H16_A1885 ) or ( H16_A3201 ) or ( H16_A2979 ) or ( H16_A1889 ) or ( H16_B0915 ) or ( H16_A1410 ) or ( H16_A0179 ) or ( H16_A0142 ) or ( H16_B1905 ) or ( H16_B1741 ) or ( H16_B1742 ) or ( H16_B0419 ) or ( H16_A0810 ) or ( H16_A0461 ) or ( H16_B1439 ) or ( H16_B0848 ) or ( H16_B0659 ) or ( H16_A1719 ) or ( H16_B2478 ) or ( H16_A0873 ) or ( H16_B2156 ) or ( H16_B0657 ) or ( H16_B0389 ) or ( H16_B1346 ) or ( H16_B0698 ) or ( H16_A1716 ) or ( H16_B0420 ) or ( H16_A2138 ) or ( H16_B0365 ) or ( H16_B0382 ) or ( H16_A1832 ) or ( H16_A2258 ) or ( H16_B0724 ) or ( H16_B1914 ) or ( H16_B1773 ) or ( H16_A0464 ) or ( H16_A1699 )

+

SUBSYSTEM: Membrane Lipid Metabolism

+

PROTEIN_CLASS: 4.2.1.17

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Oxidative Phosphorylation

+

PROTEIN_CLASS: 1.2.2.1

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0100 ) or ( H16_A3311 ) or ( H16_B1738 ) or ( H16_B0402 ) or ( H16_A3593 ) or ( H16_A1101 ) or ( H16_A0865 ) or ( H16_B1188 ) or ( H16_A3594 ) or ( H16_B0756 ) or ( H16_A1885 ) or ( H16_A3201 ) or ( H16_A2979 ) or ( H16_A1889 ) or ( H16_B0915 ) or ( H16_A1410 ) or ( H16_A0179 ) or ( H16_A0142 ) or ( H16_B1905 ) or ( H16_B1741 ) or ( H16_B1742 ) or ( H16_B0419 ) or ( H16_A0810 ) or ( H16_A0461 ) or ( H16_B1439 ) or ( H16_B0848 ) or ( H16_B0659 ) or ( H16_A1719 ) or ( H16_B2478 ) or ( H16_A0873 ) or ( H16_B2156 ) or ( H16_B0657 ) or ( H16_B0389 ) or ( H16_B1346 ) or ( H16_B0698 ) or ( H16_A1716 ) or ( H16_B0420 ) or ( H16_A2138 ) or ( H16_B0365 ) or ( H16_B0382 ) or ( H16_A1832 ) or ( H16_A2258 ) or ( H16_B0724 ) or ( H16_B1914 ) or ( H16_B1773 ) or ( H16_A0464 ) or ( H16_A1699 )

+

PROTEIN_ASSOCIATION: ( H16_A0100 ) or ( H16_A3311 ) or ( H16_B1738 ) or ( H16_B0402 ) or ( H16_A3593 ) or ( H16_A1101 ) or ( H16_A0865 ) or ( H16_B1188 ) or ( H16_A3594 ) or ( H16_B0756 ) or ( H16_A1885 ) or ( H16_A3201 ) or ( H16_A2979 ) or ( H16_A1889 ) or ( H16_B0915 ) or ( H16_A1410 ) or ( H16_A0179 ) or ( H16_A0142 ) or ( H16_B1905 ) or ( H16_B1741 ) or ( H16_B1742 ) or ( H16_B0419 ) or ( H16_A0810 ) or ( H16_A0461 ) or ( H16_B1439 ) or ( H16_B0848 ) or ( H16_B0659 ) or ( H16_A1719 ) or ( H16_B2478 ) or ( H16_A0873 ) or ( H16_B2156 ) or ( H16_B0657 ) or ( H16_B0389 ) or ( H16_B1346 ) or ( H16_B0698 ) or ( H16_A1716 ) or ( H16_B0420 ) or ( H16_A2138 ) or ( H16_B0365 ) or ( H16_B0382 ) or ( H16_A1832 ) or ( H16_A2258 ) or ( H16_B0724 ) or ( H16_B1914 ) or ( H16_B1773 ) or ( H16_A0464 ) or ( H16_A1699 )

+

SUBSYSTEM: Membrane Lipid Metabolism

+

PROTEIN_CLASS: 4.2.1.17

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A0100 ) or ( H16_A3311 ) or ( H16_B1738 ) or ( H16_B0402 ) or ( H16_A3593 ) or ( H16_A1101 ) or ( H16_A0865 ) or ( H16_B1188 ) or ( H16_A3594 ) or ( H16_B0756 ) or ( H16_A1885 ) or ( H16_A3201 ) or ( H16_A2979 ) or ( H16_A1889 ) or ( H16_B0915 ) or ( H16_A1410 ) or ( H16_A0179 ) or ( H16_A0142 ) or ( H16_B1905 ) or ( H16_B1741 ) or ( H16_B1742 ) or ( H16_B0419 ) or ( H16_A0810 ) or ( H16_A0461 ) or ( H16_B1439 ) or ( H16_B0848 ) or ( H16_B0659 ) or ( H16_A1719 ) or ( H16_B2478 ) or ( H16_A0873 ) or ( H16_B2156 ) or ( H16_B0657 ) or ( H16_B0389 ) or ( H16_B1346 ) or ( H16_B0698 ) or ( H16_A1716 ) or ( H16_B0420 ) or ( H16_A2138 ) or ( H16_B0365 ) or ( H16_B0382 ) or ( H16_A1832 ) or ( H16_A2258 ) or ( H16_B0724 ) or ( H16_B1914 ) or ( H16_B1773 ) or ( H16_A0464 ) or ( H16_A1699 )

+

PROTEIN_ASSOCIATION: ( H16_A0100 ) or ( H16_A3311 ) or ( H16_B1738 ) or ( H16_B0402 ) or ( H16_A3593 ) or ( H16_A1101 ) or ( H16_A0865 ) or ( H16_B1188 ) or ( H16_A3594 ) or ( H16_B0756 ) or ( H16_A1885 ) or ( H16_A3201 ) or ( H16_A2979 ) or ( H16_A1889 ) or ( H16_B0915 ) or ( H16_A1410 ) or ( H16_A0179 ) or ( H16_A0142 ) or ( H16_B1905 ) or ( H16_B1741 ) or ( H16_B1742 ) or ( H16_B0419 ) or ( H16_A0810 ) or ( H16_A0461 ) or ( H16_B1439 ) or ( H16_B0848 ) or ( H16_B0659 ) or ( H16_A1719 ) or ( H16_B2478 ) or ( H16_A0873 ) or ( H16_B2156 ) or ( H16_B0657 ) or ( H16_B0389 ) or ( H16_B1346 ) or ( H16_B0698 ) or ( H16_A1716 ) or ( H16_B0420 ) or ( H16_A2138 ) or ( H16_B0365 ) or ( H16_B0382 ) or ( H16_A1832 ) or ( H16_A2258 ) or ( H16_B0724 ) or ( H16_B1914 ) or ( H16_B1773 ) or ( H16_A0464 ) or ( H16_A1699 )

+

SUBSYSTEM: Fatty acid metabolism

+

PROTEIN_CLASS: 4.2.1.17

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A0100 ) or ( H16_A3311 ) or ( H16_B1738 ) or ( H16_B0402 ) or ( H16_A3593 ) or ( H16_A1101 ) or ( H16_A0865 ) or ( H16_B1188 ) or ( H16_A3594 ) or ( H16_B0756 ) or ( H16_A1885 ) or ( H16_A3201 ) or ( H16_A2979 ) or ( H16_A1889 ) or ( H16_B0915 ) or ( H16_A1410 ) or ( H16_A0179 ) or ( H16_A0142 ) or ( H16_B1905 ) or ( H16_B1741 ) or ( H16_B1742 ) or ( H16_B0419 ) or ( H16_A0810 ) or ( H16_A0461 ) or ( H16_B1439 ) or ( H16_B0848 ) or ( H16_B0659 ) or ( H16_A1719 ) or ( H16_B2478 ) or ( H16_A0873 ) or ( H16_B2156 ) or ( H16_B0657 ) or ( H16_B0389 ) or ( H16_B1346 ) or ( H16_B0698 ) or ( H16_A1716 ) or ( H16_B0420 ) or ( H16_A2138 ) or ( H16_B0365 ) or ( H16_B0382 ) or ( H16_A1832 ) or ( H16_A2258 ) or ( H16_B0724 ) or ( H16_B1914 ) or ( H16_B1773 ) or ( H16_A0464 ) or ( H16_A1699 )

+

PROTEIN_ASSOCIATION: ( H16_A0100 ) or ( H16_A3311 ) or ( H16_B1738 ) or ( H16_B0402 ) or ( H16_A3593 ) or ( H16_A1101 ) or ( H16_A0865 ) or ( H16_B1188 ) or ( H16_A3594 ) or ( H16_B0756 ) or ( H16_A1885 ) or ( H16_A3201 ) or ( H16_A2979 ) or ( H16_A1889 ) or ( H16_B0915 ) or ( H16_A1410 ) or ( H16_A0179 ) or ( H16_A0142 ) or ( H16_B1905 ) or ( H16_B1741 ) or ( H16_B1742 ) or ( H16_B0419 ) or ( H16_A0810 ) or ( H16_A0461 ) or ( H16_B1439 ) or ( H16_B0848 ) or ( H16_B0659 ) or ( H16_A1719 ) or ( H16_B2478 ) or ( H16_A0873 ) or ( H16_B2156 ) or ( H16_B0657 ) or ( H16_B0389 ) or ( H16_B1346 ) or ( H16_B0698 ) or ( H16_A1716 ) or ( H16_B0420 ) or ( H16_A2138 ) or ( H16_B0365 ) or ( H16_B0382 ) or ( H16_A1832 ) or ( H16_A2258 ) or ( H16_B0724 ) or ( H16_B1914 ) or ( H16_B1773 ) or ( H16_A0464 ) or ( H16_A1699 )

+

SUBSYSTEM: Propanoate metabolism

+

PROTEIN_CLASS: 4.2.1.17

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0100 ) or ( H16_A3311 ) or ( H16_B1738 ) or ( H16_B0402 ) or ( H16_A3593 ) or ( H16_A1101 ) or ( H16_A0865 ) or ( H16_B1188 ) or ( H16_A3594 ) or ( H16_B0756 ) or ( H16_A1885 ) or ( H16_A3201 ) or ( H16_A2979 ) or ( H16_A1889 ) or ( H16_B0915 ) or ( H16_A1410 ) or ( H16_A0179 ) or ( H16_A0142 ) or ( H16_B1905 ) or ( H16_B1741 ) or ( H16_B1742 ) or ( H16_B0419 ) or ( H16_A0810 ) or ( H16_A0461 ) or ( H16_B1439 ) or ( H16_B0848 ) or ( H16_B0659 ) or ( H16_A1719 ) or ( H16_B2478 ) or ( H16_A0873 ) or ( H16_B2156 ) or ( H16_B0657 ) or ( H16_B0389 ) or ( H16_B1346 ) or ( H16_B0698 ) or ( H16_A1716 ) or ( H16_B0420 ) or ( H16_A2138 ) or ( H16_B0365 ) or ( H16_B0382 ) or ( H16_A1832 ) or ( H16_A2258 ) or ( H16_B0724 ) or ( H16_B1914 ) or ( H16_B1773 ) or ( H16_A0464 ) or ( H16_A1699 )

+

PROTEIN_ASSOCIATION: ( H16_A0100 ) or ( H16_A3311 ) or ( H16_B1738 ) or ( H16_B0402 ) or ( H16_A3593 ) or ( H16_A1101 ) or ( H16_A0865 ) or ( H16_B1188 ) or ( H16_A3594 ) or ( H16_B0756 ) or ( H16_A1885 ) or ( H16_A3201 ) or ( H16_A2979 ) or ( H16_A1889 ) or ( H16_B0915 ) or ( H16_A1410 ) or ( H16_A0179 ) or ( H16_A0142 ) or ( H16_B1905 ) or ( H16_B1741 ) or ( H16_B1742 ) or ( H16_B0419 ) or ( H16_A0810 ) or ( H16_A0461 ) or ( H16_B1439 ) or ( H16_B0848 ) or ( H16_B0659 ) or ( H16_A1719 ) or ( H16_B2478 ) or ( H16_A0873 ) or ( H16_B2156 ) or ( H16_B0657 ) or ( H16_B0389 ) or ( H16_B1346 ) or ( H16_B0698 ) or ( H16_A1716 ) or ( H16_B0420 ) or ( H16_A2138 ) or ( H16_B0365 ) or ( H16_B0382 ) or ( H16_A1832 ) or ( H16_A2258 ) or ( H16_B0724 ) or ( H16_B1914 ) or ( H16_B1773 ) or ( H16_A0464 ) or ( H16_A1699 )

+

SUBSYSTEM: Membrane Lipid Metabolism

+

PROTEIN_CLASS: 4.2.1.17

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B0345 ) or ( H16_A3012 ) or ( H16_B1441 )

+

PROTEIN_ASSOCIATION: ( H16_B0345 ) or ( H16_A3012 ) or ( H16_B1441 )

+

SUBSYSTEM: Ascorbate and Aldarate metabolism

+

PROTEIN_CLASS: 3.1.1.17

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0345 ) or ( H16_A3012 ) or ( H16_B1441 )

+

PROTEIN_ASSOCIATION: ( H16_B0345 ) or ( H16_A3012 ) or ( H16_B1441 )

+

SUBSYSTEM: Pentose Phosphate Pathway

+

PROTEIN_CLASS: 3.1.1.17

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0100 ) or ( H16_A3311 ) or ( H16_B1738 ) or ( H16_B0402 ) or ( H16_A3593 ) or ( H16_A1101 ) or ( H16_A0865 ) or ( H16_B1188 ) or ( H16_A3594 ) or ( H16_B0756 ) or ( H16_A1885 ) or ( H16_A3201 ) or ( H16_A2979 ) or ( H16_A1889 ) or ( H16_B0915 ) or ( H16_A1410 ) or ( H16_A0179 ) or ( H16_A0142 ) or ( H16_B1905 ) or ( H16_B1741 ) or ( H16_B1742 ) or ( H16_B0419 ) or ( H16_A0810 ) or ( H16_A0461 ) or ( H16_B1439 ) or ( H16_B0848 ) or ( H16_B0659 ) or ( H16_A1719 ) or ( H16_B2478 ) or ( H16_A0873 ) or ( H16_B2156 ) or ( H16_B0657 ) or ( H16_B0389 ) or ( H16_B1346 ) or ( H16_B0698 ) or ( H16_A1716 ) or ( H16_B0420 ) or ( H16_A2138 ) or ( H16_B0365 ) or ( H16_B0382 ) or ( H16_A1832 ) or ( H16_A2258 ) or ( H16_B0724 ) or ( H16_B1914 ) or ( H16_B1773 ) or ( H16_A0464 ) or ( H16_A1699 )

+

PROTEIN_ASSOCIATION: ( H16_A0100 ) or ( H16_A3311 ) or ( H16_B1738 ) or ( H16_B0402 ) or ( H16_A3593 ) or ( H16_A1101 ) or ( H16_A0865 ) or ( H16_B1188 ) or ( H16_A3594 ) or ( H16_B0756 ) or ( H16_A1885 ) or ( H16_A3201 ) or ( H16_A2979 ) or ( H16_A1889 ) or ( H16_B0915 ) or ( H16_A1410 ) or ( H16_A0179 ) or ( H16_A0142 ) or ( H16_B1905 ) or ( H16_B1741 ) or ( H16_B1742 ) or ( H16_B0419 ) or ( H16_A0810 ) or ( H16_A0461 ) or ( H16_B1439 ) or ( H16_B0848 ) or ( H16_B0659 ) or ( H16_A1719 ) or ( H16_B2478 ) or ( H16_A0873 ) or ( H16_B2156 ) or ( H16_B0657 ) or ( H16_B0389 ) or ( H16_B1346 ) or ( H16_B0698 ) or ( H16_A1716 ) or ( H16_B0420 ) or ( H16_A2138 ) or ( H16_B0365 ) or ( H16_B0382 ) or ( H16_A1832 ) or ( H16_A2258 ) or ( H16_B0724 ) or ( H16_B1914 ) or ( H16_B1773 ) or ( H16_A0464 ) or ( H16_A1699 )

+

SUBSYSTEM: Membrane Lipid Metabolism

+

PROTEIN_CLASS: 4.2.1.17

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0100 ) or ( H16_A3311 ) or ( H16_B1738 ) or ( H16_B0402 ) or ( H16_A3593 ) or ( H16_A1101 ) or ( H16_A0865 ) or ( H16_B1188 ) or ( H16_A3594 ) or ( H16_B0756 ) or ( H16_A1885 ) or ( H16_A3201 ) or ( H16_A2979 ) or ( H16_A1889 ) or ( H16_B0915 ) or ( H16_A1410 ) or ( H16_A0179 ) or ( H16_A0142 ) or ( H16_B1905 ) or ( H16_B1741 ) or ( H16_B1742 ) or ( H16_B0419 ) or ( H16_A0810 ) or ( H16_A0461 ) or ( H16_B1439 ) or ( H16_B0848 ) or ( H16_B0659 ) or ( H16_A1719 ) or ( H16_B2478 ) or ( H16_A0873 ) or ( H16_B2156 ) or ( H16_B0657 ) or ( H16_B0389 ) or ( H16_B1346 ) or ( H16_B0698 ) or ( H16_A1716 ) or ( H16_B0420 ) or ( H16_A2138 ) or ( H16_B0365 ) or ( H16_B0382 ) or ( H16_A1832 ) or ( H16_A2258 ) or ( H16_B0724 ) or ( H16_B1914 ) or ( H16_B1773 ) or ( H16_A0464 ) or ( H16_A1699 )

+

PROTEIN_ASSOCIATION: ( H16_A0100 ) or ( H16_A3311 ) or ( H16_B1738 ) or ( H16_B0402 ) or ( H16_A3593 ) or ( H16_A1101 ) or ( H16_A0865 ) or ( H16_B1188 ) or ( H16_A3594 ) or ( H16_B0756 ) or ( H16_A1885 ) or ( H16_A3201 ) or ( H16_A2979 ) or ( H16_A1889 ) or ( H16_B0915 ) or ( H16_A1410 ) or ( H16_A0179 ) or ( H16_A0142 ) or ( H16_B1905 ) or ( H16_B1741 ) or ( H16_B1742 ) or ( H16_B0419 ) or ( H16_A0810 ) or ( H16_A0461 ) or ( H16_B1439 ) or ( H16_B0848 ) or ( H16_B0659 ) or ( H16_A1719 ) or ( H16_B2478 ) or ( H16_A0873 ) or ( H16_B2156 ) or ( H16_B0657 ) or ( H16_B0389 ) or ( H16_B1346 ) or ( H16_B0698 ) or ( H16_A1716 ) or ( H16_B0420 ) or ( H16_A2138 ) or ( H16_B0365 ) or ( H16_B0382 ) or ( H16_A1832 ) or ( H16_A2258 ) or ( H16_B0724 ) or ( H16_B1914 ) or ( H16_B1773 ) or ( H16_A0464 ) or ( H16_A1699 )

+

SUBSYSTEM: Membrane Lipid Metabolism

+

PROTEIN_CLASS: 4.2.1.17

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0345 ) or ( H16_A3012 ) or ( H16_B1441 )

+

PROTEIN_ASSOCIATION: ( H16_B0345 ) or ( H16_A3012 ) or ( H16_B1441 )

+

SUBSYSTEM: Carprolactam degradation

+

PROTEIN_CLASS: 3.1.1.17

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0804 )

+

PROTEIN_ASSOCIATION: ( H16_A0804 )

+

SUBSYSTEM: Lipopolysaccharide Biosynthesis

+

PROTEIN_CLASS: 5.1.3.20

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Glycerophospholipid Metabolism

+

PROTEIN_CLASS: 2.3.1.15

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0611 )

+

PROTEIN_ASSOCIATION: ( H16_B0611 )

+

SUBSYSTEM: Glyoxylate and Dicarboxylate metabolism

+

PROTEIN_CLASS: 1.1.1.29

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: 1,4-Dichlorobenzene degradation

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2891 ) or ( H16_B2453 )

+

PROTEIN_ASSOCIATION: ( H16_A2891 ) or ( H16_B2453 )

+

SUBSYSTEM: Porphyrin and Chlorophyll metabolism

+

PROTEIN_CLASS: 1.3.3.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Fatty acid biosynthesis

+

PROTEIN_CLASS: 2.3.1.41 2.3.1.179 2.3.1.180 1.1.1.100

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Fatty acid biosynthesis

+

PROTEIN_CLASS: 2.3.1.41 2.3.1.179 2.3.1.180 1.1.1.100

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B1386 ) or ( H16_A3146 )

+

PROTEIN_ASSOCIATION: ( H16_B1386 ) or ( H16_A3146 )

+

SUBSYSTEM: Glycolysis/Gluconeogenesis

+

PROTEIN_CLASS: 1.2.1.12

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3018 )

+

PROTEIN_ASSOCIATION: ( H16_A3018 )

+

SUBSYSTEM: Histidine Metabolism

+

PROTEIN_CLASS: 4.3.1.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0151 )

+

PROTEIN_ASSOCIATION: ( H16_A0151 )

+

SUBSYSTEM: Methionine Metabolism

+

PROTEIN_CLASS: 2.1.1.13

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1789 )

+

PROTEIN_ASSOCIATION: ( H16_A1789 )

+

SUBSYSTEM: Trinitrotoluene degradation

+

PROTEIN_CLASS: 1.-.-.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A0797 )

+

PROTEIN_ASSOCIATION: ( H16_A0797 )

+

SUBSYSTEM: Pyrimidine metabolism

+

PROTEIN_CLASS: 2.7.4.14

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1789 )

+

PROTEIN_ASSOCIATION: ( H16_A1789 )

+

SUBSYSTEM: Trinitrotoluene degradation

+

PROTEIN_CLASS: 1.-.-.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1371 ) or ( H16_B0850 ) or ( H16_B0752 ) or ( H16_A0172 ) or ( H16_B0485 )

+

PROTEIN_ASSOCIATION: ( H16_B1371 ) or ( H16_B0850 ) or ( H16_B0752 ) or ( H16_A0172 ) or ( H16_B0485 )

+

SUBSYSTEM: Valine, Leucine and Isoleucine degradation

+

PROTEIN_CLASS: 1.3.99.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A1047 )

+

PROTEIN_ASSOCIATION: ( H16_A1047 )

+

SUBSYSTEM: Glycolysis/Gluconeogenesis

+

PROTEIN_CLASS: 5.3.1.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2286 )

+

PROTEIN_ASSOCIATION: ( H16_B2286 )

+

SUBSYSTEM: Benzoate degradation via Hydroxylation

+

PROTEIN_CLASS: 1.14.13.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2758 ) or ( H16_B0321 )

+

PROTEIN_ASSOCIATION: ( H16_A2758 ) or ( H16_B0321 )

+

SUBSYSTEM: Pentose and glucuronate interconversion

+

PROTEIN_CLASS: 4.2.1.7

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B0660 ) or ( H16_A0101 ) or ( H16_B0661 ) or ( H16_B0400 ) or ( H16_B0664 ) or ( H16_B0683 ) or ( H16_B0665 ) or ( H16_B0909 ) or ( H16_A0863 ) or ( H16_B1481 ) or ( H16_B0975 ) or ( H16_B0938 ) or ( H16_A2596 ) or ( H16_B0379 ) or ( H16_B0396 ) or ( H16_B0913 ) or ( H16_B0356 ) or ( H16_B0395 ) or ( H16_B0087 ) or ( H16_A2458 ) or ( H16_A0816 ) or ( H16_B1332 ) or ( H16_B0751 ) or ( H16_B0580 ) or ( H16_A1530 ) or ( H16_B0014 ) or ( H16_B0676 ) or ( H16_A0460 ) or ( H16_B0849 ) or ( H16_B2158 ) or ( H16_A1067 ) or ( H16_B0360 ) or ( H16_B2157 ) or ( H16_B1826 ) or ( H16_B1367 ) or ( H16_B0721 ) or ( H16_A1068 ) or ( H16_B0722 ) or ( H16_B1192 ) or ( H16_B0383 ) or ( H16_B0384 ) or ( H16_A0843 ) or ( H16_B0703 ) or ( H16_B0704 ) or ( H16_B1694 )

+

PROTEIN_ASSOCIATION: ( H16_B0660 ) or ( H16_A0101 ) or ( H16_B0661 ) or ( H16_B0400 ) or ( H16_B0664 ) or ( H16_B0683 ) or ( H16_B0665 ) or ( H16_B0909 ) or ( H16_A0863 ) or ( H16_B1481 ) or ( H16_B0975 ) or ( H16_B0938 ) or ( H16_A2596 ) or ( H16_B0379 ) or ( H16_B0396 ) or ( H16_B0913 ) or ( H16_B0356 ) or ( H16_B0395 ) or ( H16_B0087 ) or ( H16_A2458 ) or ( H16_A0816 ) or ( H16_B1332 ) or ( H16_B0751 ) or ( H16_B0580 ) or ( H16_A1530 ) or ( H16_B0014 ) or ( H16_B0676 ) or ( H16_A0460 ) or ( H16_B0849 ) or ( H16_B2158 ) or ( H16_A1067 ) or ( H16_B0360 ) or ( H16_B2157 ) or ( H16_B1826 ) or ( H16_B1367 ) or ( H16_B0721 ) or ( H16_A1068 ) or ( H16_B0722 ) or ( H16_B1192 ) or ( H16_B0383 ) or ( H16_B0384 ) or ( H16_A0843 ) or ( H16_B0703 ) or ( H16_B0704 ) or ( H16_B1694 )

+

SUBSYSTEM: Valine, Leucine and Isoleucine degradation

+

PROTEIN_CLASS: 1.3.99.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1371 ) or ( H16_B0850 ) or ( H16_B0752 ) or ( H16_A0172 ) or ( H16_B0485 )

+

PROTEIN_ASSOCIATION: ( H16_B1371 ) or ( H16_B0850 ) or ( H16_B0752 ) or ( H16_A0172 ) or ( H16_B0485 )

+

SUBSYSTEM: Valine, Leucine and Isoleucine degradation

+

PROTEIN_CLASS: 1.3.99.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1465 ) or ( H16_A1732 ) or ( H16_A2086 ) or ( H16_A1546 ) or ( H16_A1734 ) or ( H16_B0814 ) or ( H16_B2014 ) or ( H16_B2013 ) or ( H16_B1172 ) or ( H16_B1643 ) or ( H16_B2126 ) or ( H16_B2069 ) or ( H16_A3386 ) or ( H16_B1666 )

+

PROTEIN_ASSOCIATION: ( H16_A1465 ) or ( H16_A1732 ) or ( H16_A2086 ) or ( H16_A1546 ) or ( H16_A1734 ) or ( H16_B0814 ) or ( H16_B2014 ) or ( H16_B2013 ) or ( H16_B1172 ) or ( H16_B1643 ) or ( H16_B2126 ) or ( H16_B2069 ) or ( H16_A3386 ) or ( H16_B1666 )

+

SUBSYSTEM: Carprolactam degradation

+

PROTEIN_CLASS: 3.5.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3244 )

+

PROTEIN_ASSOCIATION: ( H16_A3244 )

+

SUBSYSTEM: Arginine and Proline Metabolism

+

PROTEIN_CLASS: 1.14.11.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2638 ) or ( H16_B0568 ) or ( H16_A1907 )

+

PROTEIN_ASSOCIATION: ( H16_A2638 ) or ( H16_B0568 ) or ( H16_A1907 )

+

SUBSYSTEM: Citric Acid Cycle

+

PROTEIN_CLASS: 4.2.1.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Fatty acid biosynthesis

+

PROTEIN_CLASS: 2.3.1.41 2.3.1.179 2.3.1.180 1.1.1.100

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Fatty acid biosynthesis

+

PROTEIN_CLASS: 2.3.1.41 2.3.1.179 2.3.1.180 1.1.1.100

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2911 ) or ( H16_A0519 )

+

PROTEIN_ASSOCIATION: ( H16_A2911 ) or ( H16_A0519 )

+

SUBSYSTEM: Glycerophospholipid Metabolism

+

PROTEIN_CLASS: 2.3.1.51

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0875 )

+

PROTEIN_ASSOCIATION: ( H16_B0875 )

+

SUBSYSTEM: Tyrosine metabolism

+

PROTEIN_CLASS: 5.2.1.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2638 ) or ( H16_B0568 ) or ( H16_A1907 )

+

PROTEIN_ASSOCIATION: ( H16_A2638 ) or ( H16_B0568 ) or ( H16_A1907 )

+

SUBSYSTEM: Citric Acid Cycle

+

PROTEIN_CLASS: 4.2.1.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3087 )

+

PROTEIN_ASSOCIATION: ( H16_A3087 )

+

SUBSYSTEM: Folate Biosynthesis

+

PROTEIN_CLASS: 2.6.1.85

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B0663 ) or ( H16_B0572 ) or ( H16_A1828 ) or ( H16_A1256 ) or ( H16_A0679 ) or ( H16_B2561 ) or ( H16_A0893 ) or ( H16_B0034 ) or ( H16_A2586 ) or ( H16_B1417 ) or ( H16_B0831 ) or ( H16_A2460 )

+

PROTEIN_ASSOCIATION: ( H16_B0663 ) or ( H16_B0572 ) or ( H16_A1828 ) or ( H16_A1256 ) or ( H16_A0679 ) or ( H16_B2561 ) or ( H16_A0893 ) or ( H16_B0034 ) or ( H16_A2586 ) or ( H16_B1417 ) or ( H16_B0831 ) or ( H16_A2460 )

+

SUBSYSTEM: Fructose and Mannose metabolism

+

PROTEIN_CLASS: 1.1.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B1371 ) or ( H16_B0850 ) or ( H16_B0752 ) or ( H16_A0172 ) or ( H16_B0485 )

+

PROTEIN_ASSOCIATION: ( H16_B1371 ) or ( H16_B0850 ) or ( H16_B0752 ) or ( H16_A0172 ) or ( H16_B0485 )

+

SUBSYSTEM: Fatty acid biosynthesis

+

PROTEIN_CLASS: 1.3.99.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B1152 )

+

PROTEIN_ASSOCIATION: ( H16_B1152 )

+

SUBSYSTEM: Fructose and Mannose metabolism

+

PROTEIN_CLASS: 5.3.1.8

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B0660 ) or ( H16_A0101 ) or ( H16_B0661 ) or ( H16_B0400 ) or ( H16_B0664 ) or ( H16_B0683 ) or ( H16_B0665 ) or ( H16_B0909 ) or ( H16_A0863 ) or ( H16_B1481 ) or ( H16_B0975 ) or ( H16_B0938 ) or ( H16_A2596 ) or ( H16_B0379 ) or ( H16_B0396 ) or ( H16_B0913 ) or ( H16_B0356 ) or ( H16_B0395 ) or ( H16_B0087 ) or ( H16_A2458 ) or ( H16_A0816 ) or ( H16_B1332 ) or ( H16_B0751 ) or ( H16_B0580 ) or ( H16_A1530 ) or ( H16_B0014 ) or ( H16_B0676 ) or ( H16_A0460 ) or ( H16_B0849 ) or ( H16_B2158 ) or ( H16_A1067 ) or ( H16_B0360 ) or ( H16_B2157 ) or ( H16_B1826 ) or ( H16_B1367 ) or ( H16_B0721 ) or ( H16_A1068 ) or ( H16_B0722 ) or ( H16_B1192 ) or ( H16_B0383 ) or ( H16_B0384 ) or ( H16_A0843 ) or ( H16_B0703 ) or ( H16_B0704 ) or ( H16_B1694 )

+

PROTEIN_ASSOCIATION: ( H16_B0660 ) or ( H16_A0101 ) or ( H16_B0661 ) or ( H16_B0400 ) or ( H16_B0664 ) or ( H16_B0683 ) or ( H16_B0665 ) or ( H16_B0909 ) or ( H16_A0863 ) or ( H16_B1481 ) or ( H16_B0975 ) or ( H16_B0938 ) or ( H16_A2596 ) or ( H16_B0379 ) or ( H16_B0396 ) or ( H16_B0913 ) or ( H16_B0356 ) or ( H16_B0395 ) or ( H16_B0087 ) or ( H16_A2458 ) or ( H16_A0816 ) or ( H16_B1332 ) or ( H16_B0751 ) or ( H16_B0580 ) or ( H16_A1530 ) or ( H16_B0014 ) or ( H16_B0676 ) or ( H16_A0460 ) or ( H16_B0849 ) or ( H16_B2158 ) or ( H16_A1067 ) or ( H16_B0360 ) or ( H16_B2157 ) or ( H16_B1826 ) or ( H16_B1367 ) or ( H16_B0721 ) or ( H16_A1068 ) or ( H16_B0722 ) or ( H16_B1192 ) or ( H16_B0383 ) or ( H16_B0384 ) or ( H16_A0843 ) or ( H16_B0703 ) or ( H16_B0704 ) or ( H16_B1694 )

+

SUBSYSTEM: Valine, Leucine and Isoleucine degradation

+

PROTEIN_CLASS: 1.3.99.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B0660 ) or ( H16_A0101 ) or ( H16_B0661 ) or ( H16_B0400 ) or ( H16_B0664 ) or ( H16_B0683 ) or ( H16_B0665 ) or ( H16_B0909 ) or ( H16_A0863 ) or ( H16_B1481 ) or ( H16_B0975 ) or ( H16_B0938 ) or ( H16_A2596 ) or ( H16_B0379 ) or ( H16_B0396 ) or ( H16_B0913 ) or ( H16_B0356 ) or ( H16_B0395 ) or ( H16_B0087 ) or ( H16_A2458 ) or ( H16_A0816 ) or ( H16_B1332 ) or ( H16_B0751 ) or ( H16_B0580 ) or ( H16_A1530 ) or ( H16_B0014 ) or ( H16_B0676 ) or ( H16_A0460 ) or ( H16_B0849 ) or ( H16_B2158 ) or ( H16_A1067 ) or ( H16_B0360 ) or ( H16_B2157 ) or ( H16_B1826 ) or ( H16_B1367 ) or ( H16_B0721 ) or ( H16_A1068 ) or ( H16_B0722 ) or ( H16_B1192 ) or ( H16_B0383 ) or ( H16_B0384 ) or ( H16_A0843 ) or ( H16_B0703 ) or ( H16_B0704 ) or ( H16_B1694 )

+

PROTEIN_ASSOCIATION: ( H16_B0660 ) or ( H16_A0101 ) or ( H16_B0661 ) or ( H16_B0400 ) or ( H16_B0664 ) or ( H16_B0683 ) or ( H16_B0665 ) or ( H16_B0909 ) or ( H16_A0863 ) or ( H16_B1481 ) or ( H16_B0975 ) or ( H16_B0938 ) or ( H16_A2596 ) or ( H16_B0379 ) or ( H16_B0396 ) or ( H16_B0913 ) or ( H16_B0356 ) or ( H16_B0395 ) or ( H16_B0087 ) or ( H16_A2458 ) or ( H16_A0816 ) or ( H16_B1332 ) or ( H16_B0751 ) or ( H16_B0580 ) or ( H16_A1530 ) or ( H16_B0014 ) or ( H16_B0676 ) or ( H16_A0460 ) or ( H16_B0849 ) or ( H16_B2158 ) or ( H16_A1067 ) or ( H16_B0360 ) or ( H16_B2157 ) or ( H16_B1826 ) or ( H16_B1367 ) or ( H16_B0721 ) or ( H16_A1068 ) or ( H16_B0722 ) or ( H16_B1192 ) or ( H16_B0383 ) or ( H16_B0384 ) or ( H16_A0843 ) or ( H16_B0703 ) or ( H16_B0704 ) or ( H16_B1694 )

+

SUBSYSTEM: Valine, Leucine and Isoleucine degradation

+

PROTEIN_CLASS: 1.3.99.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2227 ) or ( H16_A2211 )

+

PROTEIN_ASSOCIATION: ( H16_A2227 ) or ( H16_A2211 )

+

SUBSYSTEM: Anaplerotic Reactions

+

PROTEIN_CLASS: 4.1.3.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A0272 )

+

PROTEIN_ASSOCIATION: ( H16_A0272 )

+

SUBSYSTEM: Alanine and Aspartate Metabolism

+

PROTEIN_CLASS: 2.6.1.18

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1081 ) or ( H16_A1151 )

+

PROTEIN_ASSOCIATION: ( H16_B1081 ) or ( H16_A1151 )

+

SUBSYSTEM: Methionine Metabolism

+

PROTEIN_CLASS: 2.6.1.57

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2883 )

+

PROTEIN_ASSOCIATION: ( H16_A2883 )

+

SUBSYSTEM: Lipopolysaccharide Biosynthesis

+

PROTEIN_CLASS: 2.4.99.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2012 )

+

PROTEIN_ASSOCIATION: ( H16_A2012 )

+

SUBSYSTEM: Pyrimidine metabolism

+

PROTEIN_CLASS: 2.4.2.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0856 ) or ( H16_A0845 )

+

PROTEIN_ASSOCIATION: ( H16_A0856 ) or ( H16_A0845 )

+

SUBSYSTEM: Tryptophan metabolism

+

PROTEIN_CLASS: 1.4.3.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1139 )

+

PROTEIN_ASSOCIATION: ( H16_A1139 )

+

SUBSYSTEM: Glycerophospholipid Metabolism

+

PROTEIN_CLASS: 3.1.1.32

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A1553 )

+

PROTEIN_ASSOCIATION: ( H16_A1553 )

+

SUBSYSTEM: Butanoate metabolism

+

PROTEIN_CLASS: 1.1.1.61

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0856 ) or ( H16_A0845 )

+

PROTEIN_ASSOCIATION: ( H16_A0856 ) or ( H16_A0845 )

+

SUBSYSTEM: Tyrosine metabolism

+

PROTEIN_CLASS: 1.4.3.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0856 ) or ( H16_A0845 )

+

PROTEIN_ASSOCIATION: ( H16_A0856 ) or ( H16_A0845 )

+

SUBSYSTEM: Phenylalanine metabolism

+

PROTEIN_CLASS: 1.4.3.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Fatty acid biosynthesis

+

PROTEIN_CLASS: 2.3.1.41 2.3.1.179 2.3.1.180 1.1.1.100

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0856 ) or ( H16_A0845 )

+

PROTEIN_ASSOCIATION: ( H16_A0856 ) or ( H16_A0845 )

+

SUBSYSTEM: Methionine Metabolism

+

PROTEIN_CLASS: 1.4.3.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1475 ) or ( H16_B1249 ) or ( H16_A1554 ) or ( H16_B2049 ) or ( H16_B2068 ) or ( H16_B0287 ) or ( H16_B1090 ) or ( H16_B0633 ) or ( H16_A1422 ) or ( H16_B1112 ) or ( H16_A3634 )

+

PROTEIN_ASSOCIATION: ( H16_B1475 ) or ( H16_B1249 ) or ( H16_A1554 ) or ( H16_B2049 ) or ( H16_B2068 ) or ( H16_B0287 ) or ( H16_B1090 ) or ( H16_B0633 ) or ( H16_A1422 ) or ( H16_B1112 ) or ( H16_A3634 )

+

SUBSYSTEM: 2,4-Dichlorobenzoate degradation

+

PROTEIN_CLASS: 3.1.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Galactose metabolism

+

PROTEIN_CLASS: 1.1.1.251

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0948 )

+

PROTEIN_ASSOCIATION: ( H16_A0948 )

+

SUBSYSTEM: Thiamine Metabolism

+

PROTEIN_CLASS: 3.6.1.15

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A0856 ) or ( H16_A0845 )

+

PROTEIN_ASSOCIATION: ( H16_A0856 ) or ( H16_A0845 )

+

SUBSYSTEM: Valine, Leucine and Isoleucine degradation

+

PROTEIN_CLASS: 1.4.3.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2703 )

+

PROTEIN_ASSOCIATION: ( H16_A2703 )

+

SUBSYSTEM: Pyrimidine metabolism

+

PROTEIN_CLASS: 2.1.1.45

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0229 ) or ( H16_B0917 ) or ( H16_A0228 )

+

PROTEIN_ASSOCIATION: ( H16_A0229 ) or ( H16_B0917 ) or ( H16_A0228 )

+

SUBSYSTEM: Lipopolysaccharide Biosynthesis

+

PROTEIN_CLASS: 2.3.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1070 ) or ( H16_B0359 ) or ( H16_A1069 ) or ( H16_A2151 ) or ( H16_A1289 ) or ( H16_A3307 ) or ( H16_B0706 )

+

PROTEIN_ASSOCIATION: ( H16_A1070 ) or ( H16_B0359 ) or ( H16_A1069 ) or ( H16_A2151 ) or ( H16_A1289 ) or ( H16_A3307 ) or ( H16_B0706 )

+

SUBSYSTEM: 1- and 2-Methylnaphthalene degradation

+

PROTEIN_CLASS: 4.2.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Membrane Lipid Metabolism

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Lipopolysaccharide Biosynthesis

+

PROTEIN_CLASS: 2.3.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0453 )

+

PROTEIN_ASSOCIATION: ( H16_A0453 )

+

SUBSYSTEM: Aminoacyl-tRNA Biosynthesis

+

PROTEIN_CLASS: 6.1.1.12

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Fatty acid biosynthesis

+

PROTEIN_CLASS: 2.3.1.41 2.3.1.179 2.3.1.180 1.1.1.100

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2434 ) or ( H16_A0520 ) or ( H16_B0594 ) or ( H16_B1063 ) or ( H16_A0786 ) or ( H16_A2577 ) or ( H16_B2398 )

+

PROTEIN_ASSOCIATION: ( H16_A2434 ) or ( H16_A0520 ) or ( H16_B0594 ) or ( H16_B1063 ) or ( H16_A0786 ) or ( H16_A2577 ) or ( H16_B2398 )

+

SUBSYSTEM: Rivoflavin metabolism

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Fatty acid biosynthesis

+

PROTEIN_CLASS: 2.3.1.41 2.3.1.179 2.3.1.180 1.1.1.100

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B0283 ) or ( H16_B0226 )

+

PROTEIN_ASSOCIATION: ( H16_B0283 ) or ( H16_B0226 )

+

SUBSYSTEM: Galactose metabolism

+

PROTEIN_CLASS: 5.1.3.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1772 )

+

PROTEIN_ASSOCIATION: ( H16_A1772 )

+

SUBSYSTEM: Toluene and Xylene degradation

+

PROTEIN_CLASS: 1.2.1.28

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1772 )

+

PROTEIN_ASSOCIATION: ( H16_A1772 )

+

SUBSYSTEM: Toluene and Xylene degradation

+

PROTEIN_CLASS: 1.2.1.28

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A1772 )

+

PROTEIN_ASSOCIATION: ( H16_A1772 )

+

SUBSYSTEM: Benzoate degradation via Hydroxylation

+

PROTEIN_CLASS: 1.2.1.28

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0513 ) or ( H16_B0319 ) or ( H16_B0216 )

+

PROTEIN_ASSOCIATION: ( H16_A0513 ) or ( H16_B0319 ) or ( H16_B0216 )

+

SUBSYSTEM: Vitamine B6 metabolism

+

PROTEIN_CLASS: 1.1.1.262

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1772 )

+

PROTEIN_ASSOCIATION: ( H16_A1772 )

+

SUBSYSTEM: Toluene and Xylene degradation

+

PROTEIN_CLASS: 1.2.1.28

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A0391 )

+

PROTEIN_ASSOCIATION: ( H16_A0391 )

+

SUBSYSTEM: Pentose Phosphate Pathway

+

PROTEIN_CLASS: 5.3.1.13

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1772 )

+

PROTEIN_ASSOCIATION: ( H16_A1772 )

+

SUBSYSTEM: Toluene and Xylene degradation

+

PROTEIN_CLASS: 1.2.1.28

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1772 )

+

PROTEIN_ASSOCIATION: ( H16_A1772 )

+

SUBSYSTEM: Toluene and Xylene degradation

+

PROTEIN_CLASS: 1.2.1.28

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2182 ) or ( H16_A2183 ) or ( H16_B0842 )

+

PROTEIN_ASSOCIATION: ( H16_A2182 ) or ( H16_A2183 ) or ( H16_B0842 )

+

SUBSYSTEM: Folate Biosynthesis

+

PROTEIN_CLASS: 3.1.3.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2848 )

+

PROTEIN_ASSOCIATION: ( H16_A2848 )

+

SUBSYSTEM: Rivoflavin metabolism

+

PROTEIN_CLASS: 1.1.1.193

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0445 )

+

PROTEIN_ASSOCIATION: ( H16_A0445 )

+

SUBSYSTEM: Ubiquinone Biosynthesis

+

PROTEIN_CLASS: 2.1.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0445 )

+

PROTEIN_ASSOCIATION: ( H16_A0445 )

+

SUBSYSTEM: Ubiquinone Biosynthesis

+

PROTEIN_CLASS: 2.1.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3619 )

+

PROTEIN_ASSOCIATION: ( H16_A3619 )

+

SUBSYSTEM: Glycine, Serine and threonine Metabolism

+

PROTEIN_CLASS: 2.1.2.10

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3417 )

+

PROTEIN_ASSOCIATION: ( H16_A3417 )

+

SUBSYSTEM: Histidine Metabolism

+

PROTEIN_CLASS: 2.4.2.17

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A0603 )

+

PROTEIN_ASSOCIATION: ( H16_A0603 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 2.7.4.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Putative Transporters

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2265 ) or ( H16_B0301 )

+

PROTEIN_ASSOCIATION: ( H16_A2265 ) or ( H16_B0301 )

+

SUBSYSTEM: Glycine, Serine and threonine Metabolism

+

PROTEIN_CLASS: 4.2.3.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A3042 )

+

PROTEIN_ASSOCIATION: ( H16_A3042 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 2.1.2.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

PROTEIN_CLASS: 2.7.7.7

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1081 ) or ( H16_A1083 ) or ( H16_A1084 )

+

PROTEIN_ASSOCIATION: ( H16_A1081 ) or ( H16_A1083 ) or ( H16_A1084 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 3.5.1.5

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3242 )

+

PROTEIN_ASSOCIATION: ( H16_A3242 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 2.4.2.8

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2920 )

+

PROTEIN_ASSOCIATION: ( H16_A2920 )

+

SUBSYSTEM: Porphyrin and Chlorophyll metabolism

+

PROTEIN_CLASS: 2.5.1.16

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Lipopolysaccharide Biosynthesis

+

PROTEIN_CLASS: 3.6.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1387 ) or ( H16_A3318 ) or ( H16_A0174 )

+

PROTEIN_ASSOCIATION: ( H16_B1387 ) or ( H16_A3318 ) or ( H16_A0174 )

+

SUBSYSTEM: Glyoxylate and Dicarboxylate metabolism

+

PROTEIN_CLASS: 3.1.3.18

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2446 )

+

PROTEIN_ASSOCIATION: ( H16_A2446 )

+

SUBSYSTEM: Folate Biosynthesis

+

PROTEIN_CLASS: 2.5.1.15

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2446 )

+

PROTEIN_ASSOCIATION: ( H16_A2446 )

+

SUBSYSTEM: Folate Biosynthesis

+

PROTEIN_CLASS: 2.5.1.15

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0802 )

+

PROTEIN_ASSOCIATION: ( H16_A0802 )

+

SUBSYSTEM: Nucleotide sugars metabolism

+

PROTEIN_CLASS: 1.1.1.22

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Oxidative Phosphorylation

+

PROTEIN_CLASS: 1.18.99.1

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Putative Transporters

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0072 ) or ( H16_B0476 )

+

PROTEIN_ASSOCIATION: ( H16_B0072 ) or ( H16_B0476 )

+

SUBSYSTEM: Glyoxylate and Dicarboxylate metabolism

+

PROTEIN_CLASS: 3.5.1.49

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3253 )

+

PROTEIN_ASSOCIATION: ( H16_A3253 )

+

SUBSYSTEM: Biosynthesis of steroids

+

PROTEIN_CLASS: 2.5.1.30

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: 1,1,1-Trichloro-2,2-Bis-(Chlorophenyl)Ethane (DDT) degradation

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A1569 )

+

PROTEIN_ASSOCIATION: ( H16_A1569 )

+

SUBSYSTEM: Pyrimidine metabolism

+

PROTEIN_CLASS: 2.7.4.9

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Propanoate metabolism

+

PROTEIN_CLASS: 2.3.1.54

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2135 ) or ( H16_B0495 ) or ( H16_A1145 ) or ( H16_B1480 )

+

PROTEIN_ASSOCIATION: ( H16_B2135 ) or ( H16_B0495 ) or ( H16_A1145 ) or ( H16_B1480 )

+

SUBSYSTEM: Naphthalene and Anthracene degradation

+

PROTEIN_CLASS: 1.14.13.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0663 ) or ( H16_B0572 ) or ( H16_A1828 ) or ( H16_A1256 ) or ( H16_A0679 ) or ( H16_B2561 ) or ( H16_A0893 ) or ( H16_B0034 ) or ( H16_A2586 ) or ( H16_B1417 ) or ( H16_B0831 ) or ( H16_A2460 )

+

PROTEIN_ASSOCIATION: ( H16_B0663 ) or ( H16_B0572 ) or ( H16_A1828 ) or ( H16_A1256 ) or ( H16_A0679 ) or ( H16_B2561 ) or ( H16_A0893 ) or ( H16_B0034 ) or ( H16_A2586 ) or ( H16_B1417 ) or ( H16_B0831 ) or ( H16_A2460 )

+

SUBSYSTEM: Glycine, Serine and threonine Metabolism

+

PROTEIN_CLASS: 1.1.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0096 )

+

PROTEIN_ASSOCIATION: ( H16_B0096 )

+

SUBSYSTEM: Glycerophospholipid Metabolism

+

PROTEIN_CLASS: 4.3.1.7

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3155 )

+

PROTEIN_ASSOCIATION: ( H16_A3155 )

+

SUBSYSTEM: Glycerophospholipid Metabolism

+

PROTEIN_CLASS: 3.1.3.27

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0561 )

+

PROTEIN_ASSOCIATION: ( H16_A0561 )

+

SUBSYSTEM: Valine, Leucine, and Isoleucine Metabolism

+

PROTEIN_CLASS: 2.6.1.42

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0677 ) or ( H16_B2522 ) or ( H16_B1709 ) or ( H16_A1700 ) or ( H16_A2794 ) or ( H16_A2252 ) or ( H16_A2807 ) or ( H16_A1718 ) or ( H16_A0866 ) or ( H16_A0871 ) or ( H16_A1230 ) or ( H16_B0174 ) or ( H16_A1519 ) or ( H16_B1335 ) or ( H16_B0910 ) or ( H16_B1264 ) or ( H16_B1148 ) or ( H16_B1662 ) or ( H16_A2978 )

+

PROTEIN_ASSOCIATION: ( H16_B0677 ) or ( H16_B2522 ) or ( H16_B1709 ) or ( H16_A1700 ) or ( H16_A2794 ) or ( H16_A2252 ) or ( H16_A2807 ) or ( H16_A1718 ) or ( H16_A0866 ) or ( H16_A0871 ) or ( H16_A1230 ) or ( H16_B0174 ) or ( H16_A1519 ) or ( H16_B1335 ) or ( H16_B0910 ) or ( H16_B1264 ) or ( H16_B1148 ) or ( H16_B1662 ) or ( H16_A2978 )

+

SUBSYSTEM: Carprolactam degradation

+

PROTEIN_CLASS: 6.2.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2078 ) or ( H16_B2438 )

+

PROTEIN_ASSOCIATION: ( H16_A2078 ) or ( H16_B2438 )

+

SUBSYSTEM: Oxidative Phosphorylation

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2871 )

+

PROTEIN_ASSOCIATION: ( H16_A2871 )

+

SUBSYSTEM: Peptidoglycan Biosynthesis

+

PROTEIN_CLASS: 3.6.1.27

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Benzoate degradation via Hydroxylation

+

PROTEIN_CLASS: 1.14.13.24

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2531 )

+

PROTEIN_ASSOCIATION: ( H16_B2531 )

+

SUBSYSTEM: Alanine and Aspartate Metabolism

+

PROTEIN_CLASS: 6.3.4.5

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B1630 ) or ( H16_A0670 )

+

PROTEIN_ASSOCIATION: ( H16_B1630 ) or ( H16_A0670 )

+

SUBSYSTEM: Pyruvate Metabolism

+

PROTEIN_CLASS: 2.7.2.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0042 )

+

PROTEIN_ASSOCIATION: ( H16_A0042 )

+

SUBSYSTEM: Glutathione Metabolism

+

PROTEIN_CLASS: 6.3.1.8

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2149 ) or ( H16_B0675 ) or ( H16_A2808 ) or ( H16_B0699 ) or ( H16_A2143 )

+

PROTEIN_ASSOCIATION: ( H16_A2149 ) or ( H16_B0675 ) or ( H16_A2808 ) or ( H16_B0699 ) or ( H16_A2143 )

+

SUBSYSTEM: Geraniol degrdation

+

PROTEIN_CLASS: 1.3.99.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Fatty acid biosynthesis

+

PROTEIN_CLASS: 2.3.1.179 2.3.1.180 2.3.1.86 2.3.1.41

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( PHG252 )

+

PROTEIN_ASSOCIATION: ( PHG252 )

+

SUBSYSTEM: Nitrogen Metabolism

+

PROTEIN_CLASS: 1.7.99.6

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Arginine and Proline Metabolism

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2042 )

+

PROTEIN_ASSOCIATION: ( H16_A2042 )

+

SUBSYSTEM: Lipopolysaccharide Biosynthesis

+

PROTEIN_CLASS: 2.4.1.182

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3090 ) or ( H16_A2969 )

+

PROTEIN_ASSOCIATION: ( H16_A3090 ) or ( H16_A2969 )

+

SUBSYSTEM: Porphyrin and Chlorophyll metabolism

+

PROTEIN_CLASS: 2.5.1.17

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A3090 ) or ( H16_A2969 )

+

PROTEIN_ASSOCIATION: ( H16_A3090 ) or ( H16_A2969 )

+

SUBSYSTEM: Porphyrin and Chlorophyll metabolism

+

PROTEIN_CLASS: 2.5.1.17

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B2534 ) or ( H16_B1843 )

+

PROTEIN_ASSOCIATION: ( H16_B2534 ) or ( H16_B1843 )

+

SUBSYSTEM: Butanoate metabolism

+

PROTEIN_CLASS: 4.2.1.55

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2946 ) or ( H16_A0135 )

+

PROTEIN_ASSOCIATION: ( H16_A2946 ) or ( H16_A0135 )

+

SUBSYSTEM: Biotin Metabolism

+

PROTEIN_CLASS: 6.3.4.15

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2376 )

+

PROTEIN_ASSOCIATION: ( H16_A2376 )

+

SUBSYSTEM: Nicotinate and Nicotinamide metabolism

+

PROTEIN_CLASS: 3.1.3.5

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Tryptophan metabolism

+

PROTEIN_CLASS: 2.6.1.7

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0291 ) or ( H16_A3313 )

+

PROTEIN_ASSOCIATION: ( H16_A0291 ) or ( H16_A3313 )

+

SUBSYSTEM: Phenylalanine metabolism

+

PROTEIN_CLASS: 6.2.1.30

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2376 )

+

PROTEIN_ASSOCIATION: ( H16_A2376 )

+

SUBSYSTEM: Nicotinate and Nicotinamide metabolism

+

PROTEIN_CLASS: 3.1.3.5

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A0797 )

+

PROTEIN_ASSOCIATION: ( H16_A0797 )

+

SUBSYSTEM: Pyrimidine metabolism

+

PROTEIN_CLASS: 2.7.4.14

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A0797 )

+

PROTEIN_ASSOCIATION: ( H16_A0797 )

+

SUBSYSTEM: Pyrimidine metabolism

+

PROTEIN_CLASS: 2.7.4.14

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3272 ) or ( H16_A3167 )

+

PROTEIN_ASSOCIATION: ( H16_A3272 ) or ( H16_A3167 )

+

SUBSYSTEM: Peptidoglycan Biosynthesis

+

PROTEIN_CLASS: 6.3.2.8

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0428 )

+

PROTEIN_ASSOCIATION: ( H16_A0428 )

+

SUBSYSTEM: Starch and sucrose metabolism

+

PROTEIN_CLASS: 3.1.3.12

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0757 ) or ( H16_B1109 ) or ( H16_B1420 ) or ( H16_B0223 ) or ( H16_B1836 ) or ( H16_A0633 )

+

PROTEIN_ASSOCIATION: ( H16_B0757 ) or ( H16_B1109 ) or ( H16_B1420 ) or ( H16_B0223 ) or ( H16_B1836 ) or ( H16_A0633 )

+

SUBSYSTEM: Naphthalene and Anthracene degradation

+

PROTEIN_CLASS: 1.13.11.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0757 ) or ( H16_B1109 ) or ( H16_B1420 ) or ( H16_B0223 ) or ( H16_B1836 ) or ( H16_A0633 )

+

PROTEIN_ASSOCIATION: ( H16_B0757 ) or ( H16_B1109 ) or ( H16_B1420 ) or ( H16_B0223 ) or ( H16_B1836 ) or ( H16_A0633 )

+

SUBSYSTEM: Naphthalene and Anthracene degradation

+

PROTEIN_CLASS: 1.13.11.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3106 )

+

PROTEIN_ASSOCIATION: ( H16_A3106 )

+

SUBSYSTEM: Arginine and Proline Metabolism

+

PROTEIN_CLASS: 1.5.1.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0757 ) or ( H16_B1109 ) or ( H16_B1420 ) or ( H16_B0223 ) or ( H16_B1836 ) or ( H16_A0633 )

+

PROTEIN_ASSOCIATION: ( H16_B0757 ) or ( H16_B1109 ) or ( H16_B1420 ) or ( H16_B0223 ) or ( H16_B1836 ) or ( H16_A0633 )

+

SUBSYSTEM: Styrene degradation

+

PROTEIN_CLASS: 1.13.11.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0757 ) or ( H16_B1109 ) or ( H16_B1420 ) or ( H16_B0223 ) or ( H16_B1836 ) or ( H16_A0633 )

+

PROTEIN_ASSOCIATION: ( H16_B0757 ) or ( H16_B1109 ) or ( H16_B1420 ) or ( H16_B0223 ) or ( H16_B1836 ) or ( H16_A0633 )

+

SUBSYSTEM: Naphthalene and Anthracene degradation

+

PROTEIN_CLASS: 1.13.11.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3106 )

+

PROTEIN_ASSOCIATION: ( H16_A3106 )

+

SUBSYSTEM: Arginine and Proline Metabolism

+

PROTEIN_CLASS: 1.5.1.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0757 ) or ( H16_B1109 ) or ( H16_B1420 ) or ( H16_B0223 ) or ( H16_B1836 ) or ( H16_A0633 )

+

PROTEIN_ASSOCIATION: ( H16_B0757 ) or ( H16_B1109 ) or ( H16_B1420 ) or ( H16_B0223 ) or ( H16_B1836 ) or ( H16_A0633 )

+

SUBSYSTEM: 1,1,1-Trichloro-2,2-Bis-(Chlorophenyl)Ethane (DDT) degradation

+

PROTEIN_CLASS: 1.13.11.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0757 ) or ( H16_B1109 ) or ( H16_B1420 ) or ( H16_B0223 ) or ( H16_B1836 ) or ( H16_A0633 )

+

PROTEIN_ASSOCIATION: ( H16_B0757 ) or ( H16_B1109 ) or ( H16_B1420 ) or ( H16_B0223 ) or ( H16_B1836 ) or ( H16_A0633 )

+

SUBSYSTEM: 2,4-Dichlorobenzoate degradation

+

PROTEIN_CLASS: 1.13.11.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0757 ) or ( H16_B1109 ) or ( H16_B1420 ) or ( H16_B0223 ) or ( H16_B1836 ) or ( H16_A0633 )

+

PROTEIN_ASSOCIATION: ( H16_B0757 ) or ( H16_B1109 ) or ( H16_B1420 ) or ( H16_B0223 ) or ( H16_B1836 ) or ( H16_A0633 )

+

SUBSYSTEM: 1,1,1-Trichloro-2,2-Bis-(Chlorophenyl)Ethane (DDT) degradation

+

PROTEIN_CLASS: 1.13.11.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2930 )

+

PROTEIN_ASSOCIATION: ( H16_A2930 )

+

SUBSYSTEM: Glutamate metabolism

+

PROTEIN_CLASS: 4.1.1.19

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0520 ) or ( H16_B0594 ) or ( H16_B1063 ) or ( H16_A0168 )

+

PROTEIN_ASSOCIATION: ( H16_A0520 ) or ( H16_B0594 ) or ( H16_B1063 ) or ( H16_A0168 )

+

SUBSYSTEM: Aminosugars metabolism

+

PROTEIN_CLASS: 3.1.3.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1041 ) or ( H16_B0081 )

+

PROTEIN_ASSOCIATION: ( H16_A1041 ) or ( H16_B0081 )

+

SUBSYSTEM: Valine, Leucine, and Isoleucine Metabolism

+

PROTEIN_CLASS: 2.3.3.13

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0757 ) or ( H16_B1109 ) or ( H16_B1420 ) or ( H16_B0223 ) or ( H16_B1836 ) or ( H16_A0633 )

+

PROTEIN_ASSOCIATION: ( H16_B0757 ) or ( H16_B1109 ) or ( H16_B1420 ) or ( H16_B0223 ) or ( H16_B1836 ) or ( H16_A0633 )

+

SUBSYSTEM: Naphthalene and Anthracene degradation

+

PROTEIN_CLASS: 1.13.11.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3009 )

+

PROTEIN_ASSOCIATION: ( H16_A3009 )

+

SUBSYSTEM: Alanine and Aspartate Metabolism

+

PROTEIN_CLASS: 4.1.1.12

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1027 )

+

PROTEIN_ASSOCIATION: ( H16_A1027 )

+

SUBSYSTEM: Glycerophospholipid Metabolism

+

PROTEIN_CLASS: 2.7.1.107

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Putative Transporters

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0538 ) or ( H16_B1613 ) or ( H16_A3646 ) or ( H16_A2683 )

+

PROTEIN_ASSOCIATION: ( H16_B0538 ) or ( H16_B1613 ) or ( H16_A3646 ) or ( H16_A2683 )

+

SUBSYSTEM: Transport, Outer Membrane

+

PROTEIN_CLASS: 3.6.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3061 )

+

PROTEIN_ASSOCIATION: ( H16_A3061 )

+

SUBSYSTEM: Aminosugars metabolism

+

PROTEIN_CLASS: 1.1.1.158

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2610 )

+

PROTEIN_ASSOCIATION: ( H16_A2610 )

+

SUBSYSTEM: Folate Biosynthesis

+

PROTEIN_CLASS: 6.3.2.17

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2169 ) or ( H16_A3031 )

+

PROTEIN_ASSOCIATION: ( H16_B2169 ) or ( H16_A3031 )

+

SUBSYSTEM: Biosynthesis of steroids

+

PROTEIN_CLASS: 1.17.1.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2610 )

+

PROTEIN_ASSOCIATION: ( H16_A2610 )

+

SUBSYSTEM: Folate Biosynthesis

+

PROTEIN_CLASS: 6.3.2.17

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1337 ) or ( H16_A0955 )

+

PROTEIN_ASSOCIATION: ( H16_A1337 ) or ( H16_A0955 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 2.7.6.5

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3414 )

+

PROTEIN_ASSOCIATION: ( H16_A3414 )

+

SUBSYSTEM: Histidine Metabolism

+

PROTEIN_CLASS: 4.2.1.19

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A0501 )

+

PROTEIN_ASSOCIATION: ( H16_A0501 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 2.1.2.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0600 )

+

PROTEIN_ASSOCIATION: ( H16_B0600 )

+

SUBSYSTEM: Biphenyl degradation

+

PROTEIN_CLASS: 3.7.1.8

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0569 )

+

PROTEIN_ASSOCIATION: ( H16_A0569 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 6.3.2.6

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0600 )

+

PROTEIN_ASSOCIATION: ( H16_B0600 )

+

SUBSYSTEM: Biphenyl degradation

+

PROTEIN_CLASS: 3.7.1.8

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A3057 )

+

PROTEIN_ASSOCIATION: ( H16_A3057 )

+

SUBSYSTEM: Pyrimidine metabolism

+

PROTEIN_CLASS: 4.2.1.70

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2113 ) or ( H16_B0353 ) or ( H16_B0680 ) or ( H16_A2635 )

+

PROTEIN_ASSOCIATION: ( H16_B2113 ) or ( H16_B0353 ) or ( H16_B0680 ) or ( H16_A2635 )

+

SUBSYSTEM: Citric Acid Cycle

+

PROTEIN_CLASS: 4.1.3.6

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1962 and H16_A1961 and H16_A1963 )

+

PROTEIN_ASSOCIATION: ( H16_A1962_and_H16_A1961_and_H16_A1963 )

+

SUBSYSTEM: Benzoate degradation via CoA ligation

+

PROTEIN_CLASS: 1.14.12.10

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1191 ) or ( H16_A3664 ) or ( H16_A0273 )

+

PROTEIN_ASSOCIATION: ( H16_B1191 ) or ( H16_A3664 ) or ( H16_A0273 )

+

SUBSYSTEM: Inositol metabolism

+

PROTEIN_CLASS: 1.2.1.27

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Putative Transporters

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2555 )

+

PROTEIN_ASSOCIATION: ( H16_B2555 )

+

SUBSYSTEM: Carprolactam degradation

+

PROTEIN_CLASS: 1.3.99.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B2288 ) or ( H16_A0535 )

+

PROTEIN_ASSOCIATION: ( H16_B2288 ) or ( H16_A0535 )

+

SUBSYSTEM: Benzoate degradation via Hydroxylation

+

PROTEIN_CLASS: 4.1.1.44

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Fluorobenzoate degradation

+

PROTEIN_CLASS: 2.2.1.8

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2445 )

+

PROTEIN_ASSOCIATION: ( H16_A2445 )

+

SUBSYSTEM: Aminosugars metabolism

+

PROTEIN_CLASS: 5.4.2.10

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3453 )

+

PROTEIN_ASSOCIATION: ( H16_A3453 )

+

SUBSYSTEM: Porphyrin and Chlorophyll metabolism

+

PROTEIN_CLASS: 4.2.1.24

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3622 )

+

PROTEIN_ASSOCIATION: ( H16_A3622 )

+

SUBSYSTEM: Glycine, Serine and threonine Metabolism

+

PROTEIN_CLASS: 4.3.1.17

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1786 ) or ( H16_B0970 )

+

PROTEIN_ASSOCIATION: ( H16_A1786 ) or ( H16_B0970 )

+

SUBSYSTEM: Benzoate degradation via Hydroxylation

+

PROTEIN_CLASS: 1.3.1.32

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2211 ) or ( H16_B0357 ) or ( H16_A1229 ) or ( H16_B0414 ) or ( H16_A2627 )

+

PROTEIN_ASSOCIATION: ( H16_B2211 ) or ( H16_B0357 ) or ( H16_A1229 ) or ( H16_B0414 ) or ( H16_A2627 )

+

SUBSYSTEM: Citric Acid Cycle

+

PROTEIN_CLASS: 2.3.3.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1786 ) or ( H16_B0970 )

+

PROTEIN_ASSOCIATION: ( H16_A1786 ) or ( H16_B0970 )

+

SUBSYSTEM: gamma-Hexachlorocyclohexane degradation

+

PROTEIN_CLASS: 1.3.1.32

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3017 ) or ( H16_A0695 )

+

PROTEIN_ASSOCIATION: ( H16_A3017 ) or ( H16_A0695 )

+

SUBSYSTEM: Histidine Metabolism

+

PROTEIN_CLASS: 4.2.1.49

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3045 )

+

PROTEIN_ASSOCIATION: ( H16_A3045 )

+

SUBSYSTEM: Rivoflavin metabolism

+

PROTEIN_CLASS: 2.7.1.26

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1786 ) or ( H16_B0970 )

+

PROTEIN_ASSOCIATION: ( H16_A1786 ) or ( H16_B0970 )

+

SUBSYSTEM: 1,4-Dichlorobenzene degradation

+

PROTEIN_CLASS: 1.3.1.32

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3409 )

+

PROTEIN_ASSOCIATION: ( H16_A3409 )

+

SUBSYSTEM: Histidine Metabolism

+

PROTEIN_CLASS: 3.5.4.19

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1786 ) or ( H16_B0970 )

+

PROTEIN_ASSOCIATION: ( H16_A1786 ) or ( H16_B0970 )

+

SUBSYSTEM: 1,4-Dichlorobenzene degradation

+

PROTEIN_CLASS: 1.3.1.32

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1070 ) or ( H16_B0359 ) or ( H16_A1069 ) or ( H16_A2151 ) or ( H16_A1289 ) or ( H16_A3307 ) or ( H16_B0706 )

+

PROTEIN_ASSOCIATION: ( H16_A1070 ) or ( H16_B0359 ) or ( H16_A1069 ) or ( H16_A2151 ) or ( H16_A1289 ) or ( H16_A3307 ) or ( H16_B0706 )

+

SUBSYSTEM: Tyrosine metabolism

+

PROTEIN_CLASS: 4.2.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2169 ) or ( H16_A3031 )

+

PROTEIN_ASSOCIATION: ( H16_B2169 ) or ( H16_A3031 )

+

SUBSYSTEM: Biosynthesis of steroids

+

PROTEIN_CLASS: 1.17.1.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1070 ) or ( H16_B0359 ) or ( H16_A1069 ) or ( H16_A2151 ) or ( H16_A1289 ) or ( H16_A3307 ) or ( H16_B0706 )

+

PROTEIN_ASSOCIATION: ( H16_A1070 ) or ( H16_B0359 ) or ( H16_A1069 ) or ( H16_A2151 ) or ( H16_A1289 ) or ( H16_A3307 ) or ( H16_B0706 )

+

SUBSYSTEM: Cyanoamino acid metabolism

+

PROTEIN_CLASS: 4.2.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1070 ) or ( H16_B0359 ) or ( H16_A1069 ) or ( H16_A2151 ) or ( H16_A1289 ) or ( H16_A3307 ) or ( H16_B0706 )

+

PROTEIN_ASSOCIATION: ( H16_A1070 ) or ( H16_B0359 ) or ( H16_A1069 ) or ( H16_A2151 ) or ( H16_A1289 ) or ( H16_A3307 ) or ( H16_B0706 )

+

SUBSYSTEM: Benzoate degradation via CoA ligation

+

PROTEIN_CLASS: 4.2.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0070 )

+

PROTEIN_ASSOCIATION: ( H16_B0070 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 3.2.2.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1070 ) or ( H16_B0359 ) or ( H16_A1069 ) or ( H16_A2151 ) or ( H16_A1289 ) or ( H16_A3307 ) or ( H16_B0706 )

+

PROTEIN_ASSOCIATION: ( H16_A1070 ) or ( H16_B0359 ) or ( H16_A1069 ) or ( H16_A2151 ) or ( H16_A1289 ) or ( H16_A3307 ) or ( H16_B0706 )

+

SUBSYSTEM: Benzoate degradation via CoA ligation

+

PROTEIN_CLASS: 4.2.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1070 ) or ( H16_B0359 ) or ( H16_A1069 ) or ( H16_A2151 ) or ( H16_A1289 ) or ( H16_A3307 ) or ( H16_B0706 )

+

PROTEIN_ASSOCIATION: ( H16_A1070 ) or ( H16_B0359 ) or ( H16_A1069 ) or ( H16_A2151 ) or ( H16_A1289 ) or ( H16_A3307 ) or ( H16_B0706 )

+

SUBSYSTEM: Benzoate degradation via Hydroxylation

+

PROTEIN_CLASS: 4.2.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2135 ) or ( H16_B0495 ) or ( H16_A1145 ) or ( H16_B1480 )

+

PROTEIN_ASSOCIATION: ( H16_B2135 ) or ( H16_B0495 ) or ( H16_A1145 ) or ( H16_B1480 )

+

SUBSYSTEM: Bisphenol A degradation

+

PROTEIN_CLASS: 1.14.13.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2995 and H16_A2996 and H16_B0627 and H16_B0626 )

+

PROTEIN_ASSOCIATION: ( H16_A2995_and_H16_A2996_and_H16_B0627_and_H16_B0626 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 2.7.7.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1070 ) or ( H16_B0359 ) or ( H16_A1069 ) or ( H16_A2151 ) or ( H16_A1289 ) or ( H16_A3307 ) or ( H16_B0706 )

+

PROTEIN_ASSOCIATION: ( H16_A1070 ) or ( H16_B0359 ) or ( H16_A1069 ) or ( H16_A2151 ) or ( H16_A1289 ) or ( H16_A3307 ) or ( H16_B0706 )

+

SUBSYSTEM: Benzoate degradation via Hydroxylation

+

PROTEIN_CLASS: 4.2.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Cysteine Metabolism

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0538 ) or ( H16_A3452 ) or ( H16_A0711 ) or ( H16_A0728 ) or ( H16_A1904 ) or ( H16_B0193 ) or ( H16_A2711 ) or ( H16_B2325 ) or ( H16_B2032 ) or ( H16_A1118 ) or ( H16_B0187 ) or ( H16_A3617 ) or ( H16_A0917 ) or ( H16_A1282 ) or ( H16_A2943 ) or ( H16_B1613 ) or ( H16_A3646 ) or ( H16_A0983 ) or ( H16_B1571 ) or ( H16_A2322 ) or ( H16_A0260 ) or ( H16_A3250 ) or ( H16_B2575 ) or ( H16_A2683 )

+

PROTEIN_ASSOCIATION: ( H16_B0538 ) or ( H16_A3452 ) or ( H16_A0711 ) or ( H16_A0728 ) or ( H16_A1904 ) or ( H16_B0193 ) or ( H16_A2711 ) or ( H16_B2325 ) or ( H16_B2032 ) or ( H16_A1118 ) or ( H16_B0187 ) or ( H16_A3617 ) or ( H16_A0917 ) or ( H16_A1282 ) or ( H16_A2943 ) or ( H16_B1613 ) or ( H16_A3646 ) or ( H16_A0983 ) or ( H16_B1571 ) or ( H16_A2322 ) or ( H16_A0260 ) or ( H16_A3250 ) or ( H16_B2575 ) or ( H16_A2683 )

+

SUBSYSTEM: Folate Biosynthesis

+

PROTEIN_CLASS: 3.6.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3299 ) or ( H16_B0605 ) or ( H16_A0073 ) or ( H16_B1473 )

+

PROTEIN_ASSOCIATION: ( H16_A3299 ) or ( H16_B0605 ) or ( H16_A0073 ) or ( H16_B1473 )

+

SUBSYSTEM: Phenylalanine metabolism

+

PROTEIN_CLASS: 3.5.1.32

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0490 )

+

PROTEIN_ASSOCIATION: ( H16_A0490 )

+

SUBSYSTEM: Aminoacyl-tRNA Biosynthesis

+

PROTEIN_CLASS: 6.1.1.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1428 ) or ( H16_A2777 ) or ( H16_A3109 )

+

PROTEIN_ASSOCIATION: ( H16_B1428 ) or ( H16_A2777 ) or ( H16_A3109 )

+

SUBSYSTEM: Tryptophan metabolism

+

PROTEIN_CLASS: 1.11.1.6

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1956 ) or ( H16_A2505 )

+

PROTEIN_ASSOCIATION: ( H16_B1956 ) or ( H16_A2505 )

+

SUBSYSTEM: Folate Metabolism

+

PROTEIN_CLASS: 3.5.1.10

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A3124 )

+

PROTEIN_ASSOCIATION: ( H16_A3124 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 4.3.2.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A3124 )

+

PROTEIN_ASSOCIATION: ( H16_A3124 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 4.3.2.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A1847 ) or ( H16_A2445 ) or ( H16_A2885 )

+

PROTEIN_ASSOCIATION: ( H16_A1847 ) or ( H16_A2445 ) or ( H16_A2885 )

+

SUBSYSTEM: Fructose and Mannose metabolism

+

PROTEIN_CLASS: 5.4.2.8

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0314 )

+

PROTEIN_ASSOCIATION: ( H16_A0314 )

+

SUBSYSTEM: Aminosugars metabolism

+

PROTEIN_CLASS: 3.5.1.25

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2251 )

+

PROTEIN_ASSOCIATION: ( H16_A2251 )

+

SUBSYSTEM: Butanoate metabolism

+

PROTEIN_CLASS: 3.1.1.22

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A1188 )

+

PROTEIN_ASSOCIATION: ( H16_A1188 )

+

SUBSYSTEM: Glycolysis/Gluconeogenesis

+

PROTEIN_CLASS: 4.2.1.11

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1000 )

+

PROTEIN_ASSOCIATION: ( H16_A1000 )

+

SUBSYSTEM: Glutathione Metabolism

+

PROTEIN_CLASS: 3.4.11.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2860 )

+

PROTEIN_ASSOCIATION: ( H16_A2860 )

+

SUBSYSTEM: Butanoate metabolism

+

PROTEIN_CLASS: 6.2.1.16

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0833 ) or ( H16_B1735 ) or ( H16_B2444 ) or ( H16_A0745 ) or ( H16_A1114 ) or ( H16_B1534 ) or ( H16_B0212 ) or ( H16_B1835 ) or ( H16_A0232 ) or ( H16_B0421 ) or ( H16_B0737 ) or ( H16_B1751 ) or ( H16_A1495 ) or ( H16_B1960 )

+

PROTEIN_ASSOCIATION: ( H16_B0833 ) or ( H16_B1735 ) or ( H16_B2444 ) or ( H16_A0745 ) or ( H16_A1114 ) or ( H16_B1534 ) or ( H16_B0212 ) or ( H16_B1835 ) or ( H16_A0232 ) or ( H16_B0421 ) or ( H16_B0737 ) or ( H16_B1751 ) or ( H16_A1495 ) or ( H16_B1960 )

+

SUBSYSTEM: Pyruvate Metabolism

+

PROTEIN_CLASS: 1.2.1.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2171 ) or ( H16_A1439 ) or ( H16_A2002 )

+

PROTEIN_ASSOCIATION: ( H16_A2171 ) or ( H16_A1439 ) or ( H16_A2002 )

+

SUBSYSTEM: Butanoate metabolism

+

PROTEIN_CLASS: 1.1.1.36

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1412 ) or ( H16_B1918 )

+

PROTEIN_ASSOCIATION: ( H16_A1412 ) or ( H16_B1918 )

+

SUBSYSTEM: Benzoate degradation via CoA ligation

+

PROTEIN_CLASS: 6.2.1.25

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2378 ) or ( H16_A0807 ) or ( H16_A1903 )

+

PROTEIN_ASSOCIATION: ( H16_B2378 ) or ( H16_A0807 ) or ( H16_A1903 )

+

SUBSYSTEM: Cysteine Metabolism

+

PROTEIN_CLASS: 2.5.1.47

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2217 )

+

PROTEIN_ASSOCIATION: ( H16_A2217 )

+

SUBSYSTEM: Anaplerotic Reactions

+

PROTEIN_CLASS: 4.1.3.2 2.3.3.9

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0807 )

+

PROTEIN_ASSOCIATION: ( H16_A0807 )

+

SUBSYSTEM: Selenoamino acid metabolism

+

PROTEIN_CLASS: 2.5.1.47

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A3411 )

+

PROTEIN_ASSOCIATION: ( H16_A3411 )

+

SUBSYSTEM: Histidine Metabolism

+

PROTEIN_CLASS: 5.3.1.16

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1322 )

+

PROTEIN_ASSOCIATION: ( H16_A1322 )

+

SUBSYSTEM: Glycerolipid Metabolism

+

PROTEIN_CLASS: 3.1.1.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1070 ) or ( H16_B0359 ) or ( H16_A1069 ) or ( H16_A2151 ) or ( H16_A1289 ) or ( H16_A3307 ) or ( H16_B0706 )

+

PROTEIN_ASSOCIATION: ( H16_A1070 ) or ( H16_B0359 ) or ( H16_A1069 ) or ( H16_A2151 ) or ( H16_A1289 ) or ( H16_A3307 ) or ( H16_B0706 )

+

SUBSYSTEM: Tyrosine metabolism

+

PROTEIN_CLASS: 4.2.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A1070 ) or ( H16_B0359 ) or ( H16_A1069 ) or ( H16_A2151 ) or ( H16_A1289 ) or ( H16_A3307 ) or ( H16_B0706 )

+

PROTEIN_ASSOCIATION: ( H16_A1070 ) or ( H16_B0359 ) or ( H16_A1069 ) or ( H16_A2151 ) or ( H16_A1289 ) or ( H16_A3307 ) or ( H16_B0706 )

+

SUBSYSTEM: Butanoate metabolism

+

PROTEIN_CLASS: 4.2.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Fatty acid biosynthesis

+

PROTEIN_CLASS: 2.3.1.179 2.3.1.180 2.3.1.86 2.3.1.41

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2619 ) or ( H16_A2133 )

+

PROTEIN_ASSOCIATION: ( H16_A2619 ) or ( H16_A2133 )

+

SUBSYSTEM: Valine, Leucine and Isoleucine Biosynthesis

+

PROTEIN_CLASS: 1.1.1.85

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1576 )

+

PROTEIN_ASSOCIATION: ( H16_B1576 )

+

SUBSYSTEM: Rivoflavin metabolism

+

PROTEIN_CLASS: 3.5.4.25

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2045 )

+

PROTEIN_ASSOCIATION: ( H16_A2045 )

+

SUBSYSTEM: Lipopolysaccharide Biosynthesis

+

PROTEIN_CLASS: 2.3.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A1681 ) or ( H16_A1682 )

+

PROTEIN_ASSOCIATION: ( H16_A1681 ) or ( H16_A1682 )

+

SUBSYSTEM: Pyruvate Metabolism

+

PROTEIN_CLASS: 1.1.1.28

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A3037 ) or ( H16_B0560 )

+

PROTEIN_ASSOCIATION: ( H16_A3037 ) or ( H16_B0560 )

+

SUBSYSTEM: Nicotinate and Nicotinamide metabolism

+

PROTEIN_CLASS: 2.4.2.19

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B1081 ) or ( H16_A1151 )

+

PROTEIN_ASSOCIATION: ( H16_B1081 ) or ( H16_A1151 )

+

SUBSYSTEM: Phenylalanine, Tyrosine and Tryptophan biosynthesis

+

PROTEIN_CLASS: 2.6.1.57

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Phenylalanine, Tyrosine and Tryptophan biosynthesis

+

PROTEIN_CLASS: 2.6.1.58

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A0471 )

+

PROTEIN_ASSOCIATION: ( H16_A0471 )

+

SUBSYSTEM: Glutamate metabolism

+

PROTEIN_CLASS: 1.4.1.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A1356 )

+

PROTEIN_ASSOCIATION: ( H16_A1356 )

+

SUBSYSTEM: Glutamate metabolism

+

PROTEIN_CLASS: 1.4.1.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Histidine Metabolism

+

PROTEIN_CLASS: 3.1.3.15

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Putative Transporters

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0150 )

+

PROTEIN_ASSOCIATION: ( H16_A0150 )

+

SUBSYSTEM: Glycine, Serine and threonine Metabolism

+

PROTEIN_CLASS: 2.1.1.5

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2363 )

+

PROTEIN_ASSOCIATION: ( H16_A2363 )

+

SUBSYSTEM: Aminoacyl-tRNA Biosynthesi

+

PROTEIN_CLASS: 6.1.1.21

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A0953 )

+

PROTEIN_ASSOCIATION: ( H16_A0953 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 2.7.4.8

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1067 ) or ( H16_B1166 ) or ( H16_B0534 ) or ( H16_A2724 )

+

PROTEIN_ASSOCIATION: ( H16_B1067 ) or ( H16_B1166 ) or ( H16_B0534 ) or ( H16_A2724 )

+

SUBSYSTEM: Glycerophospholipid Metabolism

+

PROTEIN_CLASS: 3.1.4.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A3025 )

+

PROTEIN_ASSOCIATION: ( H16_A3025 )

+

SUBSYSTEM: Urea Cycle and Metabolism of amino groups

+

PROTEIN_CLASS: 2.6.1.11

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1067 ) or ( H16_B1166 ) or ( H16_B0534 ) or ( H16_A2724 )

+

PROTEIN_ASSOCIATION: ( H16_B1067 ) or ( H16_B1166 ) or ( H16_B0534 ) or ( H16_A2724 )

+

SUBSYSTEM: Glycerophospholipid Metabolism

+

PROTEIN_CLASS: 3.1.4.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0833 ) or ( H16_B1735 ) or ( H16_B2444 ) or ( H16_A0745 ) or ( H16_A1114 ) or ( H16_B1534 ) or ( H16_B0212 ) or ( H16_B1835 ) or ( H16_A0232 ) or ( H16_B0421 ) or ( H16_B0737 ) or ( H16_B1751 ) or ( H16_A1495 ) or ( H16_B1960 )

+

PROTEIN_ASSOCIATION: ( H16_B0833 ) or ( H16_B1735 ) or ( H16_B2444 ) or ( H16_A0745 ) or ( H16_A1114 ) or ( H16_B1534 ) or ( H16_B0212 ) or ( H16_B1835 ) or ( H16_A0232 ) or ( H16_B0421 ) or ( H16_B0737 ) or ( H16_B1751 ) or ( H16_A1495 ) or ( H16_B1960 )

+

SUBSYSTEM: Urea Cycle and Metabolism of amino groups

+

PROTEIN_CLASS: 1.2.1.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1067 ) or ( H16_B1166 ) or ( H16_B0534 ) or ( H16_A2724 )

+

PROTEIN_ASSOCIATION: ( H16_B1067 ) or ( H16_B1166 ) or ( H16_B0534 ) or ( H16_A2724 )

+

SUBSYSTEM: Glycerophospholipid Metabolism

+

PROTEIN_CLASS: 3.1.4.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2088 )

+

PROTEIN_ASSOCIATION: ( H16_A2088 )

+

SUBSYSTEM: Glycerophospholipid Metabolism

+

PROTEIN_CLASS: 2.7.7.41

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0833 ) or ( H16_B1735 ) or ( H16_B2444 ) or ( H16_A0745 ) or ( H16_A1114 ) or ( H16_B1534 ) or ( H16_B0212 ) or ( H16_B1835 ) or ( H16_A0232 ) or ( H16_B0421 ) or ( H16_B0737 ) or ( H16_B1751 ) or ( H16_A1495 ) or ( H16_B1960 )

+

PROTEIN_ASSOCIATION: ( H16_B0833 ) or ( H16_B1735 ) or ( H16_B2444 ) or ( H16_A0745 ) or ( H16_A1114 ) or ( H16_B1534 ) or ( H16_B0212 ) or ( H16_B1835 ) or ( H16_A0232 ) or ( H16_B0421 ) or ( H16_B0737 ) or ( H16_B1751 ) or ( H16_A1495 ) or ( H16_B1960 )

+

SUBSYSTEM: 3-Chloroacrylic acid degradation

+

PROTEIN_CLASS: 1.2.1.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0833 ) or ( H16_B1735 ) or ( H16_B2444 ) or ( H16_A0745 ) or ( H16_A1114 ) or ( H16_B1534 ) or ( H16_B0212 ) or ( H16_B1835 ) or ( H16_A0232 ) or ( H16_B0421 ) or ( H16_B0737 ) or ( H16_B1751 ) or ( H16_A1495 ) or ( H16_B1960 )

+

PROTEIN_ASSOCIATION: ( H16_B0833 ) or ( H16_B1735 ) or ( H16_B2444 ) or ( H16_A0745 ) or ( H16_A1114 ) or ( H16_B1534 ) or ( H16_B0212 ) or ( H16_B1835 ) or ( H16_A0232 ) or ( H16_B0421 ) or ( H16_B0737 ) or ( H16_B1751 ) or ( H16_A1495 ) or ( H16_B1960 )

+

SUBSYSTEM: 3-Chloroacrylic acid degradation

+

PROTEIN_CLASS: 1.2.1.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A0065 )

+

PROTEIN_ASSOCIATION: ( H16_A0065 )

+

SUBSYSTEM: Glutathione Metabolism

+

PROTEIN_CLASS: 1.11.1.9

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Styrene degradation

+

PROTEIN_CLASS: 1.14.13.-

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0833 ) or ( H16_B1735 ) or ( H16_B2444 ) or ( H16_A0745 ) or ( H16_A1114 ) or ( H16_B1534 ) or ( H16_B0212 ) or ( H16_B1835 ) or ( H16_A0232 ) or ( H16_B0421 ) or ( H16_B0737 ) or ( H16_B1751 ) or ( H16_A1495 ) or ( H16_B1960 )

+

PROTEIN_ASSOCIATION: ( H16_B0833 ) or ( H16_B1735 ) or ( H16_B2444 ) or ( H16_A0745 ) or ( H16_A1114 ) or ( H16_B1534 ) or ( H16_B0212 ) or ( H16_B1835 ) or ( H16_A0232 ) or ( H16_B0421 ) or ( H16_B0737 ) or ( H16_B1751 ) or ( H16_A1495 ) or ( H16_B1960 )

+

SUBSYSTEM: Urea Cycle and Metabolism of amino groups

+

PROTEIN_CLASS: 1.2.1.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0833 ) or ( H16_B1735 ) or ( H16_B2444 ) or ( H16_A0745 ) or ( H16_A1114 ) or ( H16_B1534 ) or ( H16_B0212 ) or ( H16_B1835 ) or ( H16_A0232 ) or ( H16_B0421 ) or ( H16_B0737 ) or ( H16_B1751 ) or ( H16_A1495 ) or ( H16_B1960 )

+

PROTEIN_ASSOCIATION: ( H16_B0833 ) or ( H16_B1735 ) or ( H16_B2444 ) or ( H16_A0745 ) or ( H16_A1114 ) or ( H16_B1534 ) or ( H16_B0212 ) or ( H16_B1835 ) or ( H16_A0232 ) or ( H16_B0421 ) or ( H16_B0737 ) or ( H16_B1751 ) or ( H16_A1495 ) or ( H16_B1960 )

+

SUBSYSTEM: Ubiquinone Biosynthesis

+

PROTEIN_CLASS: 1.2.1.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0833 ) or ( H16_B1735 ) or ( H16_B2444 ) or ( H16_A0745 ) or ( H16_A1114 ) or ( H16_B1534 ) or ( H16_B0212 ) or ( H16_B1835 ) or ( H16_A0232 ) or ( H16_B0421 ) or ( H16_B0737 ) or ( H16_B1751 ) or ( H16_A1495 ) or ( H16_B1960 )

+

PROTEIN_ASSOCIATION: ( H16_B0833 ) or ( H16_B1735 ) or ( H16_B2444 ) or ( H16_A0745 ) or ( H16_A1114 ) or ( H16_B1534 ) or ( H16_B0212 ) or ( H16_B1835 ) or ( H16_A0232 ) or ( H16_B0421 ) or ( H16_B0737 ) or ( H16_B1751 ) or ( H16_A1495 ) or ( H16_B1960 )

+

SUBSYSTEM: 1,2-Dichloroethane degradation

+

PROTEIN_CLASS: 1.2.1.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0833 ) or ( H16_B1735 ) or ( H16_B2444 ) or ( H16_A0745 ) or ( H16_A1114 ) or ( H16_B1534 ) or ( H16_B0212 ) or ( H16_B1835 ) or ( H16_A0232 ) or ( H16_B0421 ) or ( H16_B0737 ) or ( H16_B1751 ) or ( H16_A1495 ) or ( H16_B1960 )

+

PROTEIN_ASSOCIATION: ( H16_B0833 ) or ( H16_B1735 ) or ( H16_B2444 ) or ( H16_A0745 ) or ( H16_A1114 ) or ( H16_B1534 ) or ( H16_B0212 ) or ( H16_B1835 ) or ( H16_A0232 ) or ( H16_B0421 ) or ( H16_B0737 ) or ( H16_B1751 ) or ( H16_A1495 ) or ( H16_B1960 )

+

SUBSYSTEM: Propanoate metabolism

+

PROTEIN_CLASS: 1.2.1.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A0795 )

+

PROTEIN_ASSOCIATION: ( H16_A0795 )

+

SUBSYSTEM: Phenylalanine, Tyrosine and Tryptophan biosynthesis

+

PROTEIN_CLASS: 2.5.1.19

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Butanoate metabolism

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2732 )

+

PROTEIN_ASSOCIATION: ( H16_A2732 )

+

SUBSYSTEM: Biosynthesis of steroids

+

PROTEIN_CLASS: 2.2.1.7

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0824 ) or ( H16_B0347 ) or ( H16_B1819 ) or ( H16_A0185 ) or ( H16_A3712 ) or ( H16_B0466 ) or ( H16_B0841 )

+

PROTEIN_ASSOCIATION: ( H16_B0824 ) or ( H16_B0347 ) or ( H16_B1819 ) or ( H16_A0185 ) or ( H16_A3712 ) or ( H16_B0466 ) or ( H16_B0841 )

+

SUBSYSTEM: Glycine, Serine and threonine Metabolism

+

PROTEIN_CLASS: 1.1.1.95

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0787 ) or ( H16_A1649 )

+

PROTEIN_ASSOCIATION: ( H16_A0787 ) or ( H16_A1649 )

+

SUBSYSTEM: Ubiquinone Biosynthesis

+

PROTEIN_CLASS: 2.1.1.64

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Oxidative Phosphorylation

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2277 )

+

PROTEIN_ASSOCIATION: ( H16_B2277 )

+

SUBSYSTEM: Nitrogen Metabolism

+

PROTEIN_CLASS: 1.7.2.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0932 ) or ( H16_B1107 )

+

PROTEIN_ASSOCIATION: ( H16_B0932 ) or ( H16_B1107 )

+

SUBSYSTEM: Glycerophospholipid Metabolism

+

PROTEIN_CLASS: 3.1.4.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2521 )

+

PROTEIN_ASSOCIATION: ( H16_A2521 )

+

SUBSYSTEM: Peptidoglycan Biosynthesis

+

PROTEIN_CLASS: 2.6.1.21

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2621 and H16_A2620 ) or ( H16_B0051 and H16_B0052 ) or ( H16_B2276 and H16_B2275 ) or ( H16_A1549 and H16_A1550 ) or ( H16_A1236 and H16_A1237 )

+

PROTEIN_ASSOCIATION: ( H16_A2621_and_H16_A2620 ) or ( H16_B0051_and_H16_B0052 ) or ( H16_B2276_and_H16_B2275 ) or ( H16_A1549_and_H16_A1550 ) or ( H16_A1236_and_H16_A1237 )

+

SUBSYSTEM: Valine, Leucine, and Isoleucine Metabolism

+

PROTEIN_CLASS: 4.2.1.33

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2621 and H16_A2620 ) or ( H16_B0051 and H16_B0052 ) or ( H16_B2276 and H16_B2275 ) or ( H16_A1549 and H16_A1550 ) or ( H16_A1236 and H16_A1237 )

+

PROTEIN_ASSOCIATION: ( H16_A2621_and_H16_A2620 ) or ( H16_B0051_and_H16_B0052 ) or ( H16_B2276_and_H16_B2275 ) or ( H16_A1549_and_H16_A1550 ) or ( H16_A1236_and_H16_A1237 )

+

SUBSYSTEM: Valine, Leucine, and Isoleucine Metabolism

+

PROTEIN_CLASS: 4.2.1.33

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0932 ) or ( H16_B1107 )

+

PROTEIN_ASSOCIATION: ( H16_B0932 ) or ( H16_B1107 )

+

SUBSYSTEM: Glycerophospholipid Metabolism

+

PROTEIN_CLASS: 3.1.4.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1561 )

+

PROTEIN_ASSOCIATION: ( H16_B1561 )

+

SUBSYSTEM: Starch and sucrose metabolism

+

PROTEIN_CLASS: 2.4.1.25

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1561 )

+

PROTEIN_ASSOCIATION: ( H16_B1561 )

+

SUBSYSTEM: Starch and sucrose metabolism

+

PROTEIN_CLASS: 2.4.1.25

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1561 )

+

PROTEIN_ASSOCIATION: ( H16_B1561 )

+

SUBSYSTEM: Starch and sucrose metabolism

+

PROTEIN_CLASS: 2.4.1.25

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A0181 )

+

PROTEIN_ASSOCIATION: ( H16_A0181 )

+

SUBSYSTEM: Biotin Metabolism

+

PROTEIN_CLASS: 2.3.1.47

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1561 )

+

PROTEIN_ASSOCIATION: ( H16_B1561 )

+

SUBSYSTEM: Starch and sucrose metabolism

+

PROTEIN_CLASS: 2.4.1.25

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2606 )

+

PROTEIN_ASSOCIATION: ( H16_A2606 )

+

SUBSYSTEM: Methionine Metabolism

+

PROTEIN_CLASS: 2.5.1.48

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B2470 ) or ( H16_B0517 ) or ( H16_A3330 ) or ( H16_B1433 ) or ( H16_A0757 ) or ( H16_B1699 ) or ( H16_B1834 ) or ( H16_B1745 )

+

PROTEIN_ASSOCIATION: ( H16_B2470 ) or ( H16_B0517 ) or ( H16_A3330 ) or ( H16_B1433 ) or ( H16_A0757 ) or ( H16_B1699 ) or ( H16_B1834 ) or ( H16_B1745 )

+

SUBSYSTEM: Pyruvate Metabolism

+

PROTEIN_CLASS: 1.1.1.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2606 )

+

PROTEIN_ASSOCIATION: ( H16_A2606 )

+

SUBSYSTEM: Methionine Metabolism

+

PROTEIN_CLASS: 2.5.1.48

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3005 ) or ( H16_B1997 )

+

PROTEIN_ASSOCIATION: ( H16_A3005 ) or ( H16_B1997 )

+

SUBSYSTEM: Glyoxylate and Dicarboxylate metabolism

+

PROTEIN_CLASS: 3.5.1.9

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2606 )

+

PROTEIN_ASSOCIATION: ( H16_A2606 )

+

SUBSYSTEM: Cysteine Metabolism

+

PROTEIN_CLASS: 2.5.1.48

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2606 )

+

PROTEIN_ASSOCIATION: ( H16_A2606 )

+

SUBSYSTEM: Methionine Metabolism

+

PROTEIN_CLASS: 2.5.1.48

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3005 ) or ( H16_B1997 )

+

PROTEIN_ASSOCIATION: ( H16_A3005 ) or ( H16_B1997 )

+

SUBSYSTEM: Tryptophan metabolism

+

PROTEIN_CLASS: 3.5.1.9

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3005 ) or ( H16_B1997 )

+

PROTEIN_ASSOCIATION: ( H16_A3005 ) or ( H16_B1997 )

+

SUBSYSTEM: Tryptophan metabolism

+

PROTEIN_CLASS: 3.5.1.9

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2606 )

+

PROTEIN_ASSOCIATION: ( H16_A2606 )

+

SUBSYSTEM: Methionine Metabolism

+

PROTEIN_CLASS: 2.5.1.48

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2606 )

+

PROTEIN_ASSOCIATION: ( H16_A2606 )

+

SUBSYSTEM: Methionine Metabolism

+

PROTEIN_CLASS: 2.5.1.48

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1909 ) or ( H16_B0681 ) or ( H16_B1436 ) or ( H16_B1444 )

+

PROTEIN_ASSOCIATION: ( H16_A1909 ) or ( H16_B0681 ) or ( H16_B1436 ) or ( H16_B1444 )

+

SUBSYSTEM: Propanoate metabolism

+

PROTEIN_CLASS: 4.2.1.79

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2470 ) or ( H16_B0517 ) or ( H16_A3330 ) or ( H16_B1433 ) or ( H16_A0757 ) or ( H16_B1699 ) or ( H16_B1834 ) or ( H16_B1745 )

+

PROTEIN_ASSOCIATION: ( H16_B2470 ) or ( H16_B0517 ) or ( H16_A3330 ) or ( H16_B1433 ) or ( H16_A0757 ) or ( H16_B1699 ) or ( H16_B1834 ) or ( H16_B1745 )

+

SUBSYSTEM: 3-Chloroacrylic acid degradation

+

PROTEIN_CLASS: 1.1.1.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2945 )

+

PROTEIN_ASSOCIATION: ( H16_A2945 )

+

SUBSYSTEM: Selenoamino acid metabolism

+

PROTEIN_CLASS: 6.1.1.10

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Putative Transporters

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2436 )

+

PROTEIN_ASSOCIATION: ( H16_A2436 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 3.6.1.11

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3415 ) or ( H16_A0793 )

+

PROTEIN_ASSOCIATION: ( H16_A3415 ) or ( H16_A0793 )

+

SUBSYSTEM: Histidine Metabolism

+

PROTEIN_CLASS: 2.6.1.9

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3266 )

+

PROTEIN_ASSOCIATION: ( H16_A3266 )

+

SUBSYSTEM: Lipopolysaccharide Biosynthesis

+

PROTEIN_CLASS: 3.5.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0462 ) or ( H16_B0200 ) or ( H16_A1290 )

+

PROTEIN_ASSOCIATION: ( H16_A0462 ) or ( H16_B0200 ) or ( H16_A1290 )

+

SUBSYSTEM: Benzoate degradation via Hydroxylation

+

PROTEIN_CLASS: 2.3.1.16

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0803 )

+

PROTEIN_ASSOCIATION: ( H16_A0803 )

+

SUBSYSTEM: Lipopolysaccharide Biosynthesis

+

PROTEIN_CLASS: 2.7.-.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3601 ) or ( H16_A2132 )

+

PROTEIN_ASSOCIATION: ( H16_A3601 ) or ( H16_A2132 )

+

SUBSYSTEM: Glycine, Serine and threonine Metabolism

+

PROTEIN_CLASS: 1.1.1.81

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2470 ) or ( H16_B0517 ) or ( H16_A3330 ) or ( H16_B1433 ) or ( H16_A0757 ) or ( H16_B1699 ) or ( H16_B1834 ) or ( H16_B1745 )

+

PROTEIN_ASSOCIATION: ( H16_B2470 ) or ( H16_B0517 ) or ( H16_A3330 ) or ( H16_B1433 ) or ( H16_A0757 ) or ( H16_B1699 ) or ( H16_B1834 ) or ( H16_B1745 )

+

SUBSYSTEM: 1- and 2-Methylnaphthalenedegradation

+

PROTEIN_CLASS: 1.1.1.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2900 )

+

PROTEIN_ASSOCIATION: ( H16_A2900 )

+

SUBSYSTEM: Fructose and Mannose metabolism

+

PROTEIN_CLASS: 4.2.1.47

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1546 )

+

PROTEIN_ASSOCIATION: ( H16_B1546 )

+

SUBSYSTEM: Phenylalanine metabolism

+

PROTEIN_CLASS: 1.14.13.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1632 ) or ( H16_B0800 )

+

PROTEIN_ASSOCIATION: ( H16_A1632 ) or ( H16_B0800 )

+

SUBSYSTEM: Phenylalanine metabolism

+

PROTEIN_CLASS: 1.14.12.19

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Fluorobenzoate degradation

+

PROTEIN_CLASS: 1.2.1.69

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0792 )

+

PROTEIN_ASSOCIATION: ( H16_A0792 )

+

SUBSYSTEM: Phenylalanine, Tyrosine and Tryptophan biosynthesis

+

PROTEIN_CLASS: 4.2.1.51

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0794 )

+

PROTEIN_ASSOCIATION: ( H16_A0794 )

+

SUBSYSTEM: Phenylalanine, Tyrosine and Tryptophan biosynthesis

+

PROTEIN_CLASS: 1.3.1.12

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B2162 ) or ( H16_A3186 )

+

PROTEIN_ASSOCIATION: ( H16_B2162 ) or ( H16_A3186 )

+

SUBSYSTEM: Glycerolipid Metabolism

+

PROTEIN_CLASS: 1.1.1.21

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B1250 ) or ( H16_A0624 )

+

PROTEIN_ASSOCIATION: ( H16_B1250 ) or ( H16_A0624 )

+

SUBSYSTEM: Benzoate degradation via Hydroxylation

+

PROTEIN_CLASS: 5.3.3.10

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1250 ) or ( H16_A0624 )

+

PROTEIN_ASSOCIATION: ( H16_B1250 ) or ( H16_A0624 )

+

SUBSYSTEM: Tyrosine metabolism

+

PROTEIN_CLASS: 5.3.3.10

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0611 )

+

PROTEIN_ASSOCIATION: ( H16_B0611 )

+

SUBSYSTEM: Glyoxylate and Dicarboxylate metabolism

+

PROTEIN_CLASS: 1.1.1.29

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B2162 ) or ( H16_A3186 )

+

PROTEIN_ASSOCIATION: ( H16_B2162 ) or ( H16_A3186 )

+

SUBSYSTEM: Glycerolipid Metabolism

+

PROTEIN_CLASS: 1.1.1.21

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Fatty acid biosynthesis

+

PROTEIN_CLASS: 6.2.1.3 1.3.99.3 4.2.1.17 1.1.1.35

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2462 )

+

PROTEIN_ASSOCIATION: ( H16_A2462 )

+

SUBSYSTEM: Propanoate metabolism

+

PROTEIN_CLASS: 6.2.1.17

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B1213 )

+

PROTEIN_ASSOCIATION: ( H16_B1213 )

+

SUBSYSTEM: Arginine and Proline metabolism

+

PROTEIN_CLASS: 4.1.2.14

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1322 )

+

PROTEIN_ASSOCIATION: ( H16_A1322 )

+

SUBSYSTEM: Glycerolipid Metabolism

+

PROTEIN_CLASS: 3.1.1.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1322 )

+

PROTEIN_ASSOCIATION: ( H16_A1322 )

+

SUBSYSTEM: Glycerolipid Metabolism

+

PROTEIN_CLASS: 3.1.1.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2290 and H16_B2291 ) or ( H16_B0795 )

+

PROTEIN_ASSOCIATION: ( H16_B2290_and_H16_B2291 ) or ( H16_B0795 )

+

SUBSYSTEM: Benzoate degradation via Hydroxylation

+

PROTEIN_CLASS: 1.13.11.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2290 and H16_B2291 ) or ( H16_B0795 )

+

PROTEIN_ASSOCIATION: ( H16_B2290_and_H16_B2291 ) or ( H16_B0795 )

+

SUBSYSTEM: Benzoate degradation via Hydroxylation

+

PROTEIN_CLASS: 1.13.11.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3631 )

+

PROTEIN_ASSOCIATION: ( H16_A3631 )

+

SUBSYSTEM: Arginine and Proline metabolism

+

PROTEIN_CLASS: 1.5.1.12

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3077 )

+

PROTEIN_ASSOCIATION: ( H16_A3077 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 6.3.3.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Putative Transporters

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2962 )

+

PROTEIN_ASSOCIATION: ( H16_A2962 )

+

SUBSYSTEM: Porphyrin and Chlorophyll metabolism

+

PROTEIN_CLASS: 2.7.1.156

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Fatty acid biosynthesis

+

PROTEIN_CLASS: 6.2.1.3 1.3.99.3 4.2.1.17 1.1.1.35

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1696 )

+

PROTEIN_ASSOCIATION: ( H16_B1696 )

+

SUBSYSTEM: Benzoate degradation via CoA ligation

+

PROTEIN_CLASS: 1.1.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0462 ) or ( H16_B0200 ) or ( H16_A1290 )

+

PROTEIN_ASSOCIATION: ( H16_A0462 ) or ( H16_B0200 ) or ( H16_A1290 )

+

SUBSYSTEM: Geraniol degrdation

+

PROTEIN_CLASS: 2.3.1.16

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0462 ) or ( H16_B0200 ) or ( H16_A1290 )

+

PROTEIN_ASSOCIATION: ( H16_A0462 ) or ( H16_B0200 ) or ( H16_A1290 )

+

SUBSYSTEM: Geraniol degrdation

+

PROTEIN_CLASS: 2.3.1.16

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0734 ) or ( H16_B0731 )

+

PROTEIN_ASSOCIATION: ( H16_B0734 ) or ( H16_B0731 )

+

SUBSYSTEM: 1,1,1-Trichloro-2,2-Bis-(Chlorophenyl)Ethane (DDT) degradation

+

PROTEIN_CLASS: 1.3.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0462 ) or ( H16_B0200 ) or ( H16_A1290 )

+

PROTEIN_ASSOCIATION: ( H16_A0462 ) or ( H16_B0200 ) or ( H16_A1290 )

+

SUBSYSTEM: Valine, Leucine and Isoleucine degradation

+

PROTEIN_CLASS: 2.3.1.16

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0600 )

+

PROTEIN_ASSOCIATION: ( H16_B0600 )

+

SUBSYSTEM: Fluorene degradation

+

PROTEIN_CLASS: 3.7.1.8

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2615 )

+

PROTEIN_ASSOCIATION: ( H16_A2615 )

+

SUBSYSTEM: Phenylalanine, Tyrosine and Tryptophan biosynthesis

+

PROTEIN_CLASS: 5.3.1.24

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2564 )

+

PROTEIN_ASSOCIATION: ( H16_B2564 )

+

SUBSYSTEM: Glycolysis/Gluconeogenesis

+

PROTEIN_CLASS: 2.7.1.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2325 )

+

PROTEIN_ASSOCIATION: ( H16_A2325 )

+

SUBSYSTEM: Tryptophan metabolism

+

PROTEIN_CLASS: 1.2.4.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2324 )

+

PROTEIN_ASSOCIATION: ( H16_A2324 )

+

SUBSYSTEM: Lysine degradation

+

PROTEIN_CLASS: 2.3.1.61

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A3551 )

+

PROTEIN_ASSOCIATION: ( H16_A3551 )

+

SUBSYSTEM: Valine, Leucine and Isoleucine degradation

+

PROTEIN_CLASS: 5.1.99.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2325 )

+

PROTEIN_ASSOCIATION: ( H16_A2325 )

+

SUBSYSTEM: Lysine degradation

+

PROTEIN_CLASS: 1.2.4.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0862 )

+

PROTEIN_ASSOCIATION: ( H16_B0862 )

+

SUBSYSTEM: Atrazine degradation

+

PROTEIN_CLASS: 3.5.4.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1179 )

+

PROTEIN_ASSOCIATION: ( H16_A1179 )

+

SUBSYSTEM: Pentose Phosphate Pathway

+

PROTEIN_CLASS: 2.7.1.12

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1039 )

+

PROTEIN_ASSOCIATION: ( H16_A1039 )

+

SUBSYSTEM: Glycerophospholipid Metabolism

+

PROTEIN_CLASS: 2.7.8.8

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1178 ) or ( H16_B2567 )

+

PROTEIN_ASSOCIATION: ( H16_A1178 ) or ( H16_B2567 )

+

SUBSYSTEM: Pentose Phosphate Pathway

+

PROTEIN_CLASS: 4.2.1.12

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3242 )

+

PROTEIN_ASSOCIATION: ( H16_A3242 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 2.4.2.8

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3406 )

+

PROTEIN_ASSOCIATION: ( H16_A3406 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 3.6.1.17

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1841 and H16_B1842 and H16_A0280 ) or ( H16_B1841 and H16_B1842 and H16_A1949 )

+

PROTEIN_ASSOCIATION: ( H16_B1841_and_H16_B1842_and_H16_A0280 ) or ( H16_B1841_and_H16_B1842_and_H16_A1949 )

+

SUBSYSTEM: Valine, Leucine and Isoleucine degradation

+

PROTEIN_CLASS: 5.4.99.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1213 )

+

PROTEIN_ASSOCIATION: ( H16_B1213 )

+

SUBSYSTEM: Pentose Phosphate Pathway

+

PROTEIN_CLASS: 4.1.2.14

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2462 )

+

PROTEIN_ASSOCIATION: ( H16_A2462 )

+

SUBSYSTEM: Propanoate metabolism

+

PROTEIN_CLASS: 6.2.1.17

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3157 )

+

PROTEIN_ASSOCIATION: ( H16_A3157 )

+

SUBSYSTEM: Pyrimidine metabolism

+

PROTEIN_CLASS: 4.1.1.23

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Arginine and Proline Metabolism

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0764 ) or ( H16_B0015 )

+

PROTEIN_ASSOCIATION: ( H16_A0764 ) or ( H16_B0015 )

+

SUBSYSTEM: Aminoacyl-tRNA Biosynthesis

+

PROTEIN_CLASS: 6.1.1.11

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Valine, Leucine and Isoleucine degradation

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Fatty acid biosynthesis

+

PROTEIN_CLASS: 6.2.1.3 1.3.99.3 4.2.1.17 1.1.1.35

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Thiamine Metabolism

+

PROTEIN_CLASS: 4.1.1.71

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Fatty acid biosynthesis

+

PROTEIN_CLASS: 6.2.1.3 1.3.99.3 4.2.1.17 1.1.1.35

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B1047 )

+

PROTEIN_ASSOCIATION: ( H16_B1047 )

+

SUBSYSTEM: Phenylalanine, Tyrosine and Tryptophan biosynthesis

+

PROTEIN_CLASS: 1.1.99.25

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B1047 )

+

PROTEIN_ASSOCIATION: ( H16_B1047 )

+

SUBSYSTEM: Phenylalanine, Tyrosine and Tryptophan biosynthesis

+

PROTEIN_CLASS: 1.1.99.25

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1014 ) or ( H16_B2033 )

+

PROTEIN_ASSOCIATION: ( H16_A1014 ) or ( H16_B2033 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 3.5.4.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Fatty acid biosynthesis

+

PROTEIN_CLASS: 6.2.1.3 1.3.99.3 4.2.1.17 1.1.1.35

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A3619 ) or ( H16_A1567 )

+

PROTEIN_ASSOCIATION: ( H16_A3619 ) or ( H16_A1567 )

+

SUBSYSTEM: Folate Metabolism

+

PROTEIN_CLASS: 2.1.2.10

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2162 ) or ( H16_A3186 )

+

PROTEIN_ASSOCIATION: ( H16_B2162 ) or ( H16_A3186 )

+

SUBSYSTEM: Pyruvate Metabolism

+

PROTEIN_CLASS: 1.1.1.21

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0833 ) or ( H16_B1735 ) or ( H16_B2444 ) or ( H16_A0745 ) or ( H16_A1114 ) or ( H16_B1534 ) or ( H16_B0212 ) or ( H16_B1835 ) or ( H16_A0232 ) or ( H16_B0421 ) or ( H16_B0737 ) or ( H16_B1751 ) or ( H16_A1495 ) or ( H16_B1960 )

+

PROTEIN_ASSOCIATION: ( H16_B0833 ) or ( H16_B1735 ) or ( H16_B2444 ) or ( H16_A0745 ) or ( H16_A1114 ) or ( H16_B1534 ) or ( H16_B0212 ) or ( H16_B1835 ) or ( H16_A0232 ) or ( H16_B0421 ) or ( H16_B0737 ) or ( H16_B1751 ) or ( H16_A1495 ) or ( H16_B1960 )

+

SUBSYSTEM: Valine, Leucine and Isoleucine degradation

+

PROTEIN_CLASS: 1.2.1.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0833 ) or ( H16_B1735 ) or ( H16_B2444 ) or ( H16_A0745 ) or ( H16_A1114 ) or ( H16_B1534 ) or ( H16_B0212 ) or ( H16_B1835 ) or ( H16_A0232 ) or ( H16_B0421 ) or ( H16_B0737 ) or ( H16_B1751 ) or ( H16_A1495 ) or ( H16_B1960 )

+

PROTEIN_ASSOCIATION: ( H16_B0833 ) or ( H16_B1735 ) or ( H16_B2444 ) or ( H16_A0745 ) or ( H16_A1114 ) or ( H16_B1534 ) or ( H16_B0212 ) or ( H16_B1835 ) or ( H16_A0232 ) or ( H16_B0421 ) or ( H16_B0737 ) or ( H16_B1751 ) or ( H16_A1495 ) or ( H16_B1960 )

+

SUBSYSTEM: Histidine Metabolism

+

PROTEIN_CLASS: 1.2.1.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0941 ) or ( H16_A1702 ) or ( H16_B0942 ) or ( H16_B0663 ) or ( H16_B0572 ) or ( H16_B2561 ) or ( H16_A0893 ) or ( H16_B0034 ) or ( H16_B2168 ) or ( H16_A2586 ) or ( H16_B1417 ) or ( H16_B0831 ) or ( H16_A0861 ) or ( H16_A2460 ) or ( H16_A1828 ) or ( H16_A2474 ) or ( H16_A1256 ) or ( H16_A0679 ) or ( H16_A1562 ) or ( H16_B0713 ) or ( H16_A0478 )

+

PROTEIN_ASSOCIATION: ( H16_B0941 ) or ( H16_A1702 ) or ( H16_B0942 ) or ( H16_B0663 ) or ( H16_B0572 ) or ( H16_B2561 ) or ( H16_A0893 ) or ( H16_B0034 ) or ( H16_B2168 ) or ( H16_A2586 ) or ( H16_B1417 ) or ( H16_B0831 ) or ( H16_A0861 ) or ( H16_A2460 ) or ( H16_A1828 ) or ( H16_A2474 ) or ( H16_A1256 ) or ( H16_A0679 ) or ( H16_A1562 ) or ( H16_B0713 ) or ( H16_A0478 )

+

SUBSYSTEM: Butanoate metabolism

+

PROTEIN_CLASS: 1.1.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0833 ) or ( H16_B1735 ) or ( H16_B2444 ) or ( H16_A0745 ) or ( H16_A1114 ) or ( H16_B1534 ) or ( H16_B0212 ) or ( H16_B1835 ) or ( H16_A0232 ) or ( H16_B0421 ) or ( H16_B0737 ) or ( H16_B1751 ) or ( H16_A1495 ) or ( H16_B1960 )

+

PROTEIN_ASSOCIATION: ( H16_B0833 ) or ( H16_B1735 ) or ( H16_B2444 ) or ( H16_A0745 ) or ( H16_A1114 ) or ( H16_B1534 ) or ( H16_B0212 ) or ( H16_B1835 ) or ( H16_A0232 ) or ( H16_B0421 ) or ( H16_B0737 ) or ( H16_B1751 ) or ( H16_A1495 ) or ( H16_B1960 )

+

SUBSYSTEM: Butanoate metabolism

+

PROTEIN_CLASS: 1.2.1.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Putative Transporters

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0833 ) or ( H16_B1735 ) or ( H16_B2444 ) or ( H16_A0745 ) or ( H16_A1114 ) or ( H16_B1534 ) or ( H16_B0212 ) or ( H16_B1835 ) or ( H16_A0232 ) or ( H16_B0421 ) or ( H16_B0737 ) or ( H16_B1751 ) or ( H16_A1495 ) or ( H16_B1960 )

+

PROTEIN_ASSOCIATION: ( H16_B0833 ) or ( H16_B1735 ) or ( H16_B2444 ) or ( H16_A0745 ) or ( H16_A1114 ) or ( H16_B1534 ) or ( H16_B0212 ) or ( H16_B1835 ) or ( H16_A0232 ) or ( H16_B0421 ) or ( H16_B0737 ) or ( H16_B1751 ) or ( H16_A1495 ) or ( H16_B1960 )

+

SUBSYSTEM: Tryptophan metabolism

+

PROTEIN_CLASS: 1.2.1.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B2162 ) or ( H16_A3186 )

+

PROTEIN_ASSOCIATION: ( H16_B2162 ) or ( H16_A3186 )

+

SUBSYSTEM: Pyruvate Metabolism

+

PROTEIN_CLASS: 1.1.1.21

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0833 ) or ( H16_B1735 ) or ( H16_B2444 ) or ( H16_A0745 ) or ( H16_A1114 ) or ( H16_B1534 ) or ( H16_B0212 ) or ( H16_B1835 ) or ( H16_A0232 ) or ( H16_B0421 ) or ( H16_B0737 ) or ( H16_B1751 ) or ( H16_A1495 ) or ( H16_B1960 )

+

PROTEIN_ASSOCIATION: ( H16_B0833 ) or ( H16_B1735 ) or ( H16_B2444 ) or ( H16_A0745 ) or ( H16_A1114 ) or ( H16_B1534 ) or ( H16_B0212 ) or ( H16_B1835 ) or ( H16_A0232 ) or ( H16_B0421 ) or ( H16_B0737 ) or ( H16_B1751 ) or ( H16_A1495 ) or ( H16_B1960 )

+

SUBSYSTEM: Tryptophan metabolism

+

PROTEIN_CLASS: 1.2.1.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A3271 )

+

PROTEIN_ASSOCIATION: ( H16_A3271 )

+

SUBSYSTEM: D-alanine metabolism

+

PROTEIN_CLASS: 6.3.2.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A0372 )

+

PROTEIN_ASSOCIATION: ( H16_A0372 )

+

SUBSYSTEM: Pentose Phosphate Pathway

+

PROTEIN_CLASS: 2.7.6.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A0336 )

+

PROTEIN_ASSOCIATION: ( H16_A0336 )

+

SUBSYSTEM: Glycerophospholipid Metabolism

+

PROTEIN_CLASS: 1.1.1.94

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1736 )

+

PROTEIN_ASSOCIATION: ( H16_A1736 )

+

SUBSYSTEM: Arginine and Proline metabolism

+

PROTEIN_CLASS: 3.5.2.10

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1209 ) or ( H16_B0491 )

+

PROTEIN_ASSOCIATION: ( H16_B1209 ) or ( H16_B0491 )

+

SUBSYSTEM: Urea Cycle and Metabolism of amino groups

+

PROTEIN_CLASS: 3.5.1.14

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A3038 )

+

PROTEIN_ASSOCIATION: ( H16_A3038 )

+

SUBSYSTEM: Nicotinate and Nicotinamide metabolism

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1212 )

+

PROTEIN_ASSOCIATION: ( H16_B1212 )

+

SUBSYSTEM: Pentose Phosphate Pathway

+

PROTEIN_CLASS: 2.7.1.45

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0262 )

+

PROTEIN_ASSOCIATION: ( H16_A0262 )

+

SUBSYSTEM: Aminosugars metabolism

+

PROTEIN_CLASS: 2.3.1.157

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3153 )

+

PROTEIN_ASSOCIATION: ( H16_A3153 )

+

SUBSYSTEM: Anaplerotic Reactions

+

PROTEIN_CLASS: 1.1.1.38

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1002 )

+

PROTEIN_ASSOCIATION: ( H16_A1002 )

+

SUBSYSTEM: Anaplerotic Reactions

+

PROTEIN_CLASS: 1.1.1.40

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0734 ) or ( H16_B0731 )

+

PROTEIN_ASSOCIATION: ( H16_B0734 ) or ( H16_B0731 )

+

SUBSYSTEM: 1,1,1-Trichloro-2,2-Bis-(Chlorophenyl)Ethane (DDT) degradation

+

PROTEIN_CLASS: 1.3.1.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3246 )

+

PROTEIN_ASSOCIATION: ( H16_A3246 )

+

SUBSYSTEM: Aminoacyl-tRNA Biosynthesi

+

PROTEIN_CLASS: 6.1.1.15

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0547 )

+

PROTEIN_ASSOCIATION: ( H16_B0547 )

+

SUBSYSTEM: Tryptophan metabolism

+

PROTEIN_CLASS: 1.2.1.32

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0757 ) or ( H16_B1109 ) or ( H16_B1420 ) or ( H16_B0223 ) or ( H16_B1836 ) or ( H16_A0633 )

+

PROTEIN_ASSOCIATION: ( H16_B0757 ) or ( H16_B1109 ) or ( H16_B1420 ) or ( H16_B0223 ) or ( H16_B1836 ) or ( H16_A0633 )

+

SUBSYSTEM: Benzoate degradation via Hydroxylation

+

PROTEIN_CLASS: 1.13.11.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Sulfur Metabolism

+

PROTEIN_CLASS: 3.1.3.7

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0547 )

+

PROTEIN_ASSOCIATION: ( H16_B0547 )

+

SUBSYSTEM: Toluene and Xylene degradation

+

PROTEIN_CLASS: 1.2.1.32

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0547 )

+

PROTEIN_ASSOCIATION: ( H16_B0547 )

+

SUBSYSTEM: Benzoate degradation via Hydroxylation

+

PROTEIN_CLASS: 1.2.1.32

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1503 )

+

PROTEIN_ASSOCIATION: ( H16_B1503 )

+

SUBSYSTEM: Fructose and Mannose metabolism

+

PROTEIN_CLASS: 2.7.1.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1000 )

+

PROTEIN_ASSOCIATION: ( H16_A1000 )

+

SUBSYSTEM: Glutathione Metabolism

+

PROTEIN_CLASS: 3.4.11.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1546 )

+

PROTEIN_ASSOCIATION: ( H16_B1546 )

+

SUBSYSTEM: Phenylalanine metabolism

+

PROTEIN_CLASS: 1.14.13.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2144 )

+

PROTEIN_ASSOCIATION: ( H16_B2144 )

+

SUBSYSTEM: Glycerophospholipid Metabolism

+

PROTEIN_CLASS: 3.6.1.26

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B0981 )

+

PROTEIN_ASSOCIATION: ( H16_B0981 )

+

SUBSYSTEM: Glutamate metabolism

+

PROTEIN_CLASS: 2.6.1.19

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1401 )

+

PROTEIN_ASSOCIATION: ( H16_A1401 )

+

SUBSYSTEM: Pyrimidine metabolism

+

PROTEIN_CLASS: 1.3.3.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2855 )

+

PROTEIN_ASSOCIATION: ( H16_A2855 )

+

SUBSYSTEM: Rivoflavin metabolism

+

PROTEIN_CLASS: 2.5.1.9

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2780 ) or ( H16_B0984 ) or ( H16_A1098 ) or ( H16_A0784 )

+

PROTEIN_ASSOCIATION: ( H16_A2780 ) or ( H16_B0984 ) or ( H16_A1098 ) or ( H16_A0784 )

+

SUBSYSTEM: Glutathione Metabolism

+

PROTEIN_CLASS: 2.3.2.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A1037 )

+

PROTEIN_ASSOCIATION: ( H16_A1037 )

+

SUBSYSTEM: Valine, Leucine, and Isoleucine Metabolism

+

PROTEIN_CLASS: 1.1.1.86

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A1037 )

+

PROTEIN_ASSOCIATION: ( H16_A1037 )

+

SUBSYSTEM: Valine, Leucine, and Isoleucine Metabolism

+

PROTEIN_CLASS: 1.1.1.86

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0760 )

+

PROTEIN_ASSOCIATION: ( H16_B0760 )

+

SUBSYSTEM: Fructose and Mannose metabolism

+

PROTEIN_CLASS: 3.1.3.46

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0430 )

+

PROTEIN_ASSOCIATION: ( H16_A0430 )

+

SUBSYSTEM: Starch and sucrose metabolism

+

PROTEIN_CLASS: 2.4.1.15

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2849 )

+

PROTEIN_ASSOCIATION: ( H16_A2849 )

+

SUBSYSTEM: Rivoflavin metabolism

+

PROTEIN_CLASS: 2.5.1.9

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Fatty acid biosynthesis

+

PROTEIN_CLASS: 6.2.1.3 1.3.99.3 4.2.1.17 1.1.1.35

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A3036 )

+

PROTEIN_ASSOCIATION: ( H16_A3036 )

+

SUBSYSTEM: Nicotinate and Nicotinamide metabolism

+

PROTEIN_CLASS: 1.4.3.16

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2883 )

+

PROTEIN_ASSOCIATION: ( H16_A2883 )

+

SUBSYSTEM: Lipopolysaccharide Biosynthesis

+

PROTEIN_CLASS: 2.4.99.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Valine, Leucine, and Isoleucine Metabolism

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Fatty acid biosynthesis

+

PROTEIN_CLASS: 6.2.1.3 1.3.99.3 4.2.1.17 1.1.1.35

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A3036 )

+

PROTEIN_ASSOCIATION: ( H16_A3036 )

+

SUBSYSTEM: Alanine and Aspartate Metabolism

+

PROTEIN_CLASS: 1.4.3.16

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0449 )

+

PROTEIN_ASSOCIATION: ( H16_B0449 )

+

SUBSYSTEM: Valine, Leucine and Isoleucine Biosynthesis

+

PROTEIN_CLASS: 1.4.1.9

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B0449 )

+

PROTEIN_ASSOCIATION: ( H16_B0449 )

+

SUBSYSTEM: Valine, Leucine and Isoleucine degradation

+

PROTEIN_CLASS: 1.4.1.9

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3621 )

+

PROTEIN_ASSOCIATION: ( H16_A3621 )

+

SUBSYSTEM: Glycine, Serine and threonine Metabolism

+

PROTEIN_CLASS: 1.4.4.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Fatty acid biosynthesis

+

PROTEIN_CLASS: 6.2.1.3 1.3.99.3 4.2.1.17 1.1.1.35

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2354 ) or ( H16_B1994 )

+

PROTEIN_ASSOCIATION: ( H16_A2354 ) or ( H16_B1994 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 6.3.4.4

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2235 )

+

PROTEIN_ASSOCIATION: ( H16_B2235 )

+

SUBSYSTEM: Valine, Leucine and Isoleucine degradation

+

PROTEIN_CLASS: 2.3.1.168

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2235 )

+

PROTEIN_ASSOCIATION: ( H16_B2235 )

+

SUBSYSTEM: Valine, Leucine and Isoleucine degradation

+

PROTEIN_CLASS: 2.3.1.168

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2235 )

+

PROTEIN_ASSOCIATION: ( H16_B2235 )

+

SUBSYSTEM: Valine, Leucine and Isoleucine degradation

+

PROTEIN_CLASS: 2.3.1.168

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0833 ) or ( H16_B1735 ) or ( H16_B2444 ) or ( H16_A0745 ) or ( H16_A1114 ) or ( H16_B1534 ) or ( H16_B0212 ) or ( H16_B1835 ) or ( H16_A0232 ) or ( H16_B0421 ) or ( H16_B0737 ) or ( H16_B1751 ) or ( H16_A1495 ) or ( H16_B1960 )

+

PROTEIN_ASSOCIATION: ( H16_B0833 ) or ( H16_B1735 ) or ( H16_B2444 ) or ( H16_A0745 ) or ( H16_A1114 ) or ( H16_B1534 ) or ( H16_B0212 ) or ( H16_B1835 ) or ( H16_A0232 ) or ( H16_B0421 ) or ( H16_B0737 ) or ( H16_B1751 ) or ( H16_A1495 ) or ( H16_B1960 )

+

SUBSYSTEM: Pyruvate Metabolism

+

PROTEIN_CLASS: 1.2.1.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B0833 ) or ( H16_B1735 ) or ( H16_B2444 ) or ( H16_A0745 ) or ( H16_A1114 ) or ( H16_B1534 ) or ( H16_B0212 ) or ( H16_B1835 ) or ( H16_A0232 ) or ( H16_B0421 ) or ( H16_B0737 ) or ( H16_B1751 ) or ( H16_A1495 ) or ( H16_B1960 )

+

PROTEIN_ASSOCIATION: ( H16_B0833 ) or ( H16_B1735 ) or ( H16_B2444 ) or ( H16_A0745 ) or ( H16_A1114 ) or ( H16_B1534 ) or ( H16_B0212 ) or ( H16_B1835 ) or ( H16_A0232 ) or ( H16_B0421 ) or ( H16_B0737 ) or ( H16_B1751 ) or ( H16_A1495 ) or ( H16_B1960 )

+

SUBSYSTEM: Glycerolipid Metabolism

+

PROTEIN_CLASS: 1.2.1.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B1939 ) or ( H16_B1358 )

+

PROTEIN_ASSOCIATION: ( H16_B1939 ) or ( H16_B1358 )

+

SUBSYSTEM: Phenylalanine metabolism

+

PROTEIN_CLASS: 1.2.1.39

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A0666 )

+

PROTEIN_ASSOCIATION: ( H16_A0666 )

+

SUBSYSTEM: Glycolysis/Gluconeogenesis

+

PROTEIN_CLASS: 1.1.1.27

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_B0811 ) or ( H16_A0923 )

+

PROTEIN_ASSOCIATION: ( H16_B0811 ) or ( H16_A0923 )

+

SUBSYSTEM: Butanoate metabolism

+

PROTEIN_CLASS: 5.2.1.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A1971 ) or ( H16_A2568 )

+

PROTEIN_ASSOCIATION: ( H16_A1971 ) or ( H16_A2568 )

+

SUBSYSTEM: Fatty acid biosynthesis

+

PROTEIN_CLASS: 2.3.1.39 2.3.1.86

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1972 ) or ( H16_A1291 ) or ( H16_A0167 )

+

PROTEIN_ASSOCIATION: ( H16_A1972 ) or ( H16_A1291 ) or ( H16_A0167 )

+

SUBSYSTEM: Valine, Leucine and Isoleucine degradation

+

PROTEIN_CLASS: 1.3.99.10

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A0953 )

+

PROTEIN_ASSOCIATION: ( H16_A0953 )

+

SUBSYSTEM: Purine metabolism

+

PROTEIN_CLASS: 2.7.4.8

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1038 )

+

PROTEIN_ASSOCIATION: ( H16_A1038 )

+

SUBSYSTEM: Glycerophospholipid Metabolism

+

PROTEIN_CLASS: 4.1.1.65

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2194 ) or ( H16_A3430 ) or ( H16_B2192 ) or ( H16_A3431 ) or ( H16_B2193 )

+

PROTEIN_ASSOCIATION: ( H16_B2194 ) or ( H16_A3430 ) or ( H16_B2192 ) or ( H16_A3431 ) or ( H16_B2193 )

+

SUBSYSTEM: Glutamate metabolism

+

PROTEIN_CLASS: 1.4.1.13

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1139 )

+

PROTEIN_ASSOCIATION: ( H16_A1139 )

+

SUBSYSTEM: Glycerophospholipid Metabolism

+

PROTEIN_CLASS: 3.1.1.32

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0611 )

+

PROTEIN_ASSOCIATION: ( H16_B0611 )

+

SUBSYSTEM: Glycine, Serine and threonine Metabolism

+

PROTEIN_CLASS: 1.1.1.29

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Fatty acid biosynthesis

+

PROTEIN_CLASS: 6.2.1.3 1.3.99.3 4.2.1.17 1.1.1.35

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3408 )

+

PROTEIN_ASSOCIATION: ( H16_A3408 )

+

SUBSYSTEM: Histidine Metabolism

+

PROTEIN_CLASS: 3.6.1.31

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A3080 ) or ( H16_A1452 ) or ( H16_B1164 )

+

PROTEIN_ASSOCIATION: ( H16_A3080 ) or ( H16_A1452 ) or ( H16_B1164 )

+

SUBSYSTEM: Glycine, Serine and threonine Metabolism

+

PROTEIN_CLASS: 3.1.3.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0046 )

+

PROTEIN_ASSOCIATION: ( H16_B0046 )

+

SUBSYSTEM: Nitrogen Metabolism

+

PROTEIN_CLASS: 4.2.1.104

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Fatty acid biosynthesis

+

PROTEIN_CLASS: 6.2.1.3 1.3.99.3 4.2.1.17 1.1.1.35

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2529 )

+

PROTEIN_ASSOCIATION: ( H16_A2529 )

+

SUBSYSTEM: Glutamate metabolism

+

PROTEIN_CLASS: 5.1.1.3

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1223 and H16_A2611 )

+

PROTEIN_ASSOCIATION: ( H16_A1223_and_H16_A2611 )

+

SUBSYSTEM: Fatty acid biosynthesis

+

PROTEIN_CLASS: 6.4.1.2

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A0791 )

+

PROTEIN_ASSOCIATION: ( H16_A0791 )

+

SUBSYSTEM: Glycine, Serine and threonine Metabolism

+

PROTEIN_CLASS: 2.6.1.52

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Propanoate metabolism

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A2763 ) or ( H16_A3184 ) or ( H16_B0550 )

+

PROTEIN_ASSOCIATION: ( H16_A2763 ) or ( H16_A3184 ) or ( H16_B0550 )

+

SUBSYSTEM: Benzoate degradation via Hydroxylation

+

PROTEIN_CLASS: 5.3.2.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0508 ) or ( H16_A1505 ) or ( H16_A0770 ) or ( H16_A0817 ) or ( H16_B1893 )

+

PROTEIN_ASSOCIATION: ( H16_B0508 ) or ( H16_A1505 ) or ( H16_A0770 ) or ( H16_A0817 ) or ( H16_B1893 )

+

SUBSYSTEM: Alanine and Aspartate Metabolism

+

PROTEIN_CLASS: 1.4.99.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1964 ) or ( H16_B0968 )

+

PROTEIN_ASSOCIATION: ( H16_A1964 ) or ( H16_B0968 )

+

SUBSYSTEM: Benzoate degradation via Hydroxylation

+

PROTEIN_CLASS: 1.13.11.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1964 ) or ( H16_B0968 )

+

PROTEIN_ASSOCIATION: ( H16_A1964 ) or ( H16_B0968 )

+

SUBSYSTEM: Fluorobenzoate degradation

+

PROTEIN_CLASS: 1.13.11.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2135 ) or ( H16_B0495 ) or ( H16_A1145 ) or ( H16_B1480 )

+

PROTEIN_ASSOCIATION: ( H16_B2135 ) or ( H16_B0495 ) or ( H16_A1145 ) or ( H16_B1480 )

+

SUBSYSTEM: 1- and 2-Methylnaphthalene degradation

+

PROTEIN_CLASS: 1.14.13.-

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1964 ) or ( H16_B0968 )

+

PROTEIN_ASSOCIATION: ( H16_A1964 ) or ( H16_B0968 )

+

SUBSYSTEM: Fluorobenzoate degradation

+

PROTEIN_CLASS: 1.13.11.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Putative Transporters

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1964 ) or ( H16_B0968 )

+

PROTEIN_ASSOCIATION: ( H16_A1964 ) or ( H16_B0968 )

+

SUBSYSTEM: Toluene and Xylene degradation

+

PROTEIN_CLASS: 1.13.11.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1964 ) or ( H16_B0968 )

+

PROTEIN_ASSOCIATION: ( H16_A1964 ) or ( H16_B0968 )

+

SUBSYSTEM: gamma-Hexachlorocyclohexane degradation

+

PROTEIN_CLASS: 1.13.11.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1964 ) or ( H16_B0968 )

+

PROTEIN_ASSOCIATION: ( H16_A1964 ) or ( H16_B0968 )

+

SUBSYSTEM: gamma-Hexachlorocyclohexane degradation

+

PROTEIN_CLASS: 1.13.11.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1964 ) or ( H16_B0968 )

+

PROTEIN_ASSOCIATION: ( H16_A1964 ) or ( H16_B0968 )

+

SUBSYSTEM: 1,4-Dichlorobenzene degradation

+

PROTEIN_CLASS: 1.13.11.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1924 )

+

PROTEIN_ASSOCIATION: ( H16_A1924 )

+

SUBSYSTEM: Folate Biosynthesis

+

PROTEIN_CLASS: 4.2.3.12

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Fatty acid biosynthesis

+

PROTEIN_CLASS: 6.2.1.3 1.3.99.3 4.2.1.17 1.1.1.35

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Fatty acid biosynthesis

+

PROTEIN_CLASS: 6.2.1.3 1.3.99.3 4.2.1.17 1.1.1.35

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A3599 ) or ( H16_A1558 )

+

PROTEIN_ASSOCIATION: ( H16_A3599 ) or ( H16_A1558 )

+

SUBSYSTEM: Glyoxylate and Dicarboxylate metabolism

+

PROTEIN_CLASS: 5.3.1.22

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B2323 )

+

PROTEIN_ASSOCIATION: ( H16_B2323 )

+

SUBSYSTEM: Nitrogen Metabolism

+

PROTEIN_CLASS: 1.7.99.7

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

SUBSYSTEM: Transport, Extracellular

+

PROTEIN_CLASS: NA

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + +

REVERSIBILITY: true

+

GENE_ASSOCIATION: ( H16_A2834 )

+

PROTEIN_ASSOCIATION: ( H16_A2834 )

+

SUBSYSTEM: Glycine, Serine and threonine Metabolism

+

PROTEIN_CLASS: 2.1.2.1

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1139 )

+

PROTEIN_ASSOCIATION: ( H16_A1139 )

+

SUBSYSTEM: Glycerophospholipid Metabolism

+

PROTEIN_CLASS: 3.1.1.32

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_B0797 )

+

PROTEIN_ASSOCIATION: ( H16_B0797 )

+

SUBSYSTEM: Pyrimidine metabolism

+

PROTEIN_CLASS: 3.5.4.12

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

GENE_ASSOCIATION: ( H16_A1139 )

+

PROTEIN_ASSOCIATION: ( H16_A1139 )

+

SUBSYSTEM: Glycerophospholipid Metabolism

+

PROTEIN_CLASS: 3.1.1.32

+

GENERIC: false

+

TYPE: small

+

HOLE: false

+ + + + + + + + + + + + + + + + + + + + + + + + +

REVERSIBILITY: false

+

SUBSYSTEM: Styrene degradation

+

PROTEIN_CLASS: 1.14.13.-

+

GENERIC: false

+

TYPE: small

+

HOLE: true

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + 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b/C_necator_core/box_positions.json @@ -0,0 +1 @@ +{"Map": {"name": "Map", "background": "map1.svg", "bg-size": 1, "box-size": 1.610510000000001, "zoom": -6, "pos": [0, 0], "boxes": {"ACK": [767.3684210526311, 1951.5789473684197], "ACS": [873.7358319643101, 1745.7793722746853], "AKGDH": [1624.1341007049402, 1632.761639088499], "Ex_PHB": [318.0861244019136, 2032.5358851674623], "ALD": [1416.4671306085556, 194.98060340634262], "CITL": [1070.5970150184105, 2026.230592182495], "EDA": [257.80352776624886, 1185.3035759367763], "EDD": [242.98723306703914, 788.2268779979563], "PGL": [251.87700988656496, 601.541564787914], "GPD": [248.91375094672304, 405.9664747583459], "RUBISCO": [1073.895280964101, 943.1574542352311], "PRK": [1456.026556466288, 834.877612652688], "FDH": [1300.870674590612, 1069.7364772829408], "TKT2": [1476.2350542657782, 480.10299331210047], "TAL": [1459.9050204796524, 300.4726216647159], "SBPase": [1858.3578448611236, 300.4726216647159], "RPE": [1407.6489123640497, 578.0831960288557], "STH": [1793.0377097166202, 937.3439393236247], "SUCOA": [1685.2594867281894, 1430.510959664626], "ICD": [1701.5895205143152, 1760.3776421443683], "ACH": [1466.4370339941029, 1969.4020746067795], "SUCD": [1548.0872029247319, 1267.210621803367], "FUMC": [1191.2973932366294, 1400.0885358088963], "PGI": [267.8125540924642, 179.63037164738452], "FBPase": [689.1274257745115, 182.8963784046097], "FBA": [715.255479832313, 355.9947365375439], "PGK": [721.7874933467633, 757.7135676762401], "TPI": [525.8270879132529, 499.6990338554515], "GAPD": [682.5954122600612, 597.6792365722067], "GAPDH": [865.4917906646709, 594.4132298149815], "PGM": [725.0535001039884, 927.5459190519492], "ENO": [734.851520375664, 1110.442297456559], "PPS": [604.2112500866571, 1322.7327366761951], "PYK": [930.8119258091743, 1319.46672991897], "PEPC": [1156.1663920577114, 1250.8805880172413], "MAS": [1458.0904326275634, 1508.1292626388242], "MDH": [1205.156493416089, 1639.5353921270369], "PYRC": [1035.32414204038, 1626.4713650981362], "PTA": [527.4220047293355, 1726.0464846309742], "PhaA": [398.45282438147115, 1570.9492502253083], "PhaB": [280.8765811213649, 1757.1116353871432], "PhaCE": [254.7485270635635, 1904.081939462276], "AclAB": [1087.5802501559826, 1855.0918381038985], "XFPK1": [1054.920182583731, 111.04422974565588], "TKT1": [950.4079663525254, 313.5366486936166], "XFPK2": [1025.5261217687043, 695.6594392889618], "Ex_for": [1537.4356574502071, 1095.5597526030583], "Ex_frc": [946.348091724864, -62.62478273933855], "MAE": [1019.4420381476009, 1409.8191862347567], "ICL": [1458.8951705657134, 1713.197998462489], "CITS": [1021.7601933312297, 1714.2488293430931], "APPS": [719.6450531103678, 1758.3780071281628], "Ex_pyr": [31.94122949683308, 1403.3402929713077], "PDH": [675.5158753252981, 1486.8138361431184], "RPI": [1649.752338734145, 641.5703539521675], "BIOMASS": [1778.7453199520412, 1921.3165097191893]}}} \ No newline at end of file diff --git a/C_necator_core/map1.svg b/C_necator_core/map1.svg new file mode 100644 index 0000000..67a213d --- /dev/null +++ b/C_necator_core/map1.svg @@ -0,0 +1,105 @@ + + + + + + + image/svg+xml + + + + + + + + Biomass + Ex_frc + Ex_for + Ex_pyr + diff --git a/C_necator_core/meta.json b/C_necator_core/meta.json new file mode 100644 index 0000000..347f351 --- /dev/null +++ b/C_necator_core/meta.json @@ -0,0 +1 @@ +{"format version": 2, "description": "Read the Excel file from the publication \nhttps://doi.org/10.1016/j.ymben.2022.08.005\nwith \nhttps://github.com/MJanasch/ThermoCup/blob/main/CupriavidusCoreFBA/ThermoCup_ReadExcel_FBA.m\nand exported model to SBML. The model now contains the reaction needed for both growth on fructose and on formate.\nThe map is figure 1c from the publication.\n"} \ No newline at end of file diff --git a/C_necator_core/model.sbml b/C_necator_core/model.sbml new file mode 100644 index 0000000..717141f --- /dev/null +++ b/C_necator_core/model.sbml @@ -0,0 +1,1662 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + 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"EX_HYDROGEN_MOLECULE_e": [0.0, 0.0], "ACKr": [-1000, 1000], "R_ATPM": [3, 1000], "EX_BETA_D_FRUCTOSE_e": [-3, 0], "EX_UREA_e": [0.0, 0.0], "EX_ARG_e": [0.0, 0.0], "EX_ASN_e": [0.0, 0.0], "EX_CARBON_MONOXIDE_e": [0.0, 0.0], "EX_CYS_e": [0.0, 0.0], "EX_D_ALANINE_e": [0.0, 0.0], "EX_D_LACTATE_e": [0.0, 0.0], "EX_ETOH_e": [0.0, 0.0], "EX_FORMATE_e": [0.0, 0.0], "EX_GLN_e": [0.0, 0.0], "EX_GLT_e": [0.0, 0.0], "EX_GLYCEROL_e": [0.0, 0.0], "EX_GLY_e": [0.0, 0.0], "EX_HIS_e": [0.0, 0.0], "EX_HYPOXANTHINE_e": [0.0, 0.0], "EX_ILE_e": [0.0, 0.0], "EX_LEU_e": [0.0, 0.0], "EX_LYS_e": [0.0, 0.0], "EX_L_ALPHA_ALANINE_e": [0.0, 0.0], "EX_L_ASPARTATE_e": [0.0, 0.0], "EX_MET_e": [0.0, 0.0], "EX_PHE_e": [0.0, 0.0], "EX_PROPIONATE_e": [0.0, 0.0], "EX_PRO_e": [0.0, 0.0], "EX_PYRUVATE_e": [0.0, 0.0], "EX_SER_e": [0.0, 0.0], "EX_SUC_e": [0.0, 0.0], "EX_THR_e": [0.0, 0.0], "EX_TRP_e": [0.0, 0.0], "EX_TYR_e": [0.0, 0.0], "EX_URACIL_e": [0.0, 0.0], "EX_VAL_e": [0.0, 0.0], "EX_XANTHINE_e": [0.0, 0.0]}, "pinned_reactions": [], "description": "", "objective_direction": "max", "objective_coefficients": {"EX_PHB_e": 1.0}, "use_scenario_objective": true, "version": 1} \ No newline at end of file diff --git a/C_necator_iCN1361/PHB_from_fructose.scen b/C_necator_iCN1361/PHB_from_fructose.scen new file mode 100644 index 0000000..f017f61 --- /dev/null +++ b/C_necator_iCN1361/PHB_from_fructose.scen @@ -0,0 +1 @@ +{"fluxes": {"EX_PHB_e": [0, 1000], "EX_ACET_e": [0.0, 0.0], "EX_HYDROGEN_MOLECULE_e": [0.0, 0.0], "ACKr": [-1000, 1000], "R_ATPM": [3, 1000], "EX_BETA_D_FRUCTOSE_e": [-3, 0], "EX_UREA_e": [0.0, 0.0], "EX_ARG_e": [0.0, 0.0], "EX_ASN_e": [0.0, 0.0], "EX_CARBON_MONOXIDE_e": [0.0, 0.0], "EX_CYS_e": [0.0, 0.0], "EX_D_ALANINE_e": [0.0, 0.0], "EX_D_LACTATE_e": [0.0, 0.0], "EX_ETOH_e": [0.0, 0.0], "EX_FORMATE_e": [0.0, 0.0], "EX_GLN_e": [0.0, 0.0], "EX_GLT_e": [0.0, 0.0], "EX_GLYCEROL_e": [0.0, 0.0], "EX_GLY_e": [0.0, 0.0], "EX_HIS_e": [0.0, 0.0], "EX_HYPOXANTHINE_e": [0.0, 0.0], "EX_ILE_e": 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