diff --git a/ECC2/box_positions.json b/ECC2/box_positions.json
index b8e7cad..61f0ee5 100644
--- a/ECC2/box_positions.json
+++ b/ECC2/box_positions.json
@@ -1,331 +1 @@
-{
-    "Core Metabolism": {
-        "name": "Map",
-        "background": "map1.svg",
-        "bg-size": 1.9999999999999998,
-        "box-size": 1,
-        "zoom": -1,
-        "pos": [
-            508,
-            240
-        ],
-        "boxes": {
-            "EX_glc_e": [
-                136.1189089220017,
-                108.56067381889811
-            ],
-            "GLCptspp": [
-                420.51461380446653,
-                56.674879841782015
-            ],
-            "GLCt2pp": [
-                322.93124474092826,
-                127.92114270445839
-            ],
-            "HEX1": [
-                587.7503520284749,
-                116.09552362845176
-            ],
-            "G6PDH2r": [
-                849.9460237431543,
-                70.70107297778294
-            ],
-            "PGL": [
-                1039.2079551031634,
-                69.70107297778294
-            ],
-            "F6PA": [
-                496.70335268552014,
-                286.29771627774994
-            ],
-            "PGI": [
-                726.5038112782596,
-                176.63018887467717
-            ],
-            "GND": [
-                1157.8211997573917,
-                190.42833909156678
-            ],
-            "PFK": [
-                620.9167597600324,
-                309.92756228623927
-            ],
-            "FBP": [
-                736.2449507653714,
-                304.75653009690586
-            ],
-            "RPE": [
-                1093.5715881600554,
-                307.9845730160172
-            ],
-            "RPI": [
-                1196.1586396782825,
-                311.2126159351285
-            ],
-            "GLYCDx": [
-                373.9183133706874,
-                442.39596788713493
-            ],
-            "FBA": [
-                602.2896417324763,
-                385.37439920891
-            ],
-            "TKT2": [
-                821.2048842560425,
-                416.1417318320227
-            ],
-            "TKT1": [
-                1091.8566418089445,
-                389.7734743173548
-            ],
-            "TALA": [
-                1089.7996310791666,
-                486.01846145691513
-            ],
-            "TPI": [
-                583.5485022453645,
-                469.1633005102476
-            ],
-            "G3PD2": [
-                535.04003013514,
-                607.7457275706989
-            ],
-            "G3PD5": [
-                429.1941181040246,
-                604.4298563280329
-            ],
-            "GLYK": [
-                448.1633005102476,
-                709.0169078462601
-            ],
-            "EX_glyc_e": [
-                192.81836074850358,
-                764.1637474167575
-            ],
-            "PGK": [
-                732.9552726587062,
-                677.7626717911479
-            ],
-            "GAPD": [
-                733.8412511991506,
-                563.4344807858089
-            ],
-            "PGM": [
-                730.8982619289285,
-                788.8058091475978
-            ],
-            "ENO": [
-                734.1263048480398,
-                876.5947104489354
-            ],
-            "EDA": [
-                1246.8335195200648,
-                708.5870151440384
-            ],
-            "EDD": [
-                1354.721432687901,
-                138.47421735518074
-            ],
-            "EX_h_e": [
-                1687.1878658614603,
-                701.1252133988328
-            ],
-            "EX_h2o_e": [
-                1612.510542794775,
-                758.6828818762685
-            ],
-            "EX_co2_e": [
-                1606.5308450291814,
-                811.9809389407983
-            ],
-            "PPC": [
-                599.0948803299093,
-                927.0570022499734
-            ],
-            "PPCK": [
-                506.14056624779505,
-                1001.0351352707742
-            ],
-            "PYK": [
-                631.0472424525361,
-                1026.9140886178538
-            ],
-            "PPS": [
-                724.8309200448692,
-                1020.2553615974159
-            ],
-            "MGSA": [
-                1258.5806234762415,
-                897.5927306580032
-            ],
-            "GLYOX3": [
-                1258.9953052313508,
-                1005.523225801431
-            ],
-            "LDH_D": [
-                989.2057717605553,
-                1032.81686090362
-            ],
-            "FHL": [
-                1128.2592655163908,
-                1096.8922216386545
-            ],
-            "PFL": [
-                864.1284590660332,
-                1139.7473560470476
-            ],
-            "ME2": [
-                516.5314290642178,
-                1113.2830844550774
-            ],
-            "ME1": [
-                518.3607925744368,
-                1166.0409911492366
-            ],
-            "PDH": [
-                633.7793782485211,
-                1222.042943108724
-            ],
-            "POX": [
-                1044.451768985371,
-                1198.4080350269728
-            ],
-            "PTAr": [
-                898.1542299642072,
-                1278.459576823321
-            ],
-            "ACALD": [
-                959.4002271890231,
-                1326.9734382521517
-            ],
-            "ACKr": [
-                1290.8504396397439,
-                1266.5568045375549
-            ],
-            "ALCD2x": [
-                1309.655984211276,
-                1327.8028017623706
-            ],
-            "EX_ac_e": [
-                1664.0290481732502,
-                1277.6806966287031
-            ],
-            "EX_etoh_e": [
-                1665.0290481732502,
-                1325.542356519551
-            ],
-            "CS": [
-                782.1930134607236,
-                1350.0609534428
-            ],
-            "EX_succ_e": [
-                128.19020030617904,
-                1959.8201513137842
-            ],
-            "SUCCt2_2pp": [
-                301.21626488913887,
-                1863.7306237058249
-            ],
-            "SUCDi": [
-                414.181031200033,
-                1873.3994130363956
-            ],
-            "FRD2": [
-                510.19558998912385,
-                1862.5335257019117
-            ],
-            "FUM": [
-                397.3822001983073,
-                1706.9679574616653
-            ],
-            "MDH": [
-                401.9594584212965,
-                1542.1808164426823
-            ],
-            "MALS": [
-                599.9215196667201,
-                1597.0875113380907
-            ],
-            "SUCOAS": [
-                826.0900282952816,
-                1968.7808016317895
-            ],
-            "AKGDH": [
-                995.8456421575672,
-                1812.1370326967344
-            ],
-            "ICL": [
-                914.2742289259494,
-                1597.3761404495851
-            ],
-            "ACONTa": [
-                969.1809238213577,
-                1446.7435158765807
-            ],
-            "ACONTb": [
-                1033.9535060512499,
-                1554.2682765559027
-            ],
-            "ICDHyr": [
-                1059.4442737250745,
-                1665.0019589962178
-            ],
-            "ADK1": [
-                1390.4140792041617,
-                1433.877628542097
-            ],
-            "ATPM": [
-                1332.1516988645008,
-                1489.0729525489999
-            ],
-            "ATPS4rpp": [
-                1505.4490417737147,
-                1489.7172671047472
-            ],
-            "EX_o2_e": [
-                1668.8229570406413,
-                1593.1936646790764
-            ],
-            "CYTBO3_4pp": [
-                1482.072952549,
-                1657.0816663467194
-            ],
-            "NADH16pp": [
-                1318.285811530017,
-                1731.7201359110954
-            ],
-            "NADH17pp": [
-                1438.9650886553175,
-                1771.8279998047778
-            ],
-            "NADTRHD": [
-                1304.1906861806772,
-                1858.4299235474864
-            ],
-            "THD2pp": [
-                1510.464477798014,
-                1919.301446102543
-            ],
-            "EX_lac__D_e": [
-                1635.1147447337753,
-                1053.9151679749589
-            ],
-            "EX_h2_e": [
-                1604.5308450291814,
-                886.3580461257649
-            ],
-            "EX_for_e": [
-                1635.507501721212,
-                1162.1589811014649
-            ],
-            "SUCCt3pp": [
-                324.2818407756536,
-                1957.8201513137842
-            ],
-            "Ec_biomass_iJO1366_core_53p95M": [
-                1604.0,
-                645.0
-            ]
-        }
-    }
-}
\ No newline at end of file
+{"Map": {"name": "Map", "background": "map1.svg", "bg-size": 1.9487171000000019, "box-size": 1, "zoom": -13, "pos": [0, 0], "boxes": {"GLCptspp": [420.51461380446653, 56.674879841782015], "GLCt2pp": [322.93124474092826, 127.92114270445839], "HEX1": [587.7503520284749, 116.09552362845176], "G6PDH2r": [836.9773114426544, 132.95089202018283], "PGL": [995.1143332814634, 48.95113329698298], "F6PA": [478.5471554648202, 286.29771627774994], "PGI": [726.5038112782596, 176.63018887467717], "GND": [1151.9750484573915, 188.47962199156677], "PFK": [597.5730776191324, 296.95884998573933], "FBP": [736.2449507653714, 304.75653009690586], "RPE": [1093.5715881600554, 307.9845730160172], "RPI": [1196.1586396782825, 311.2126159351285], "GLYCDx": [326.5359657085874, 426.96071120633496], "FBA": [602.2896417324763, 385.37439920891], "TKT2": [821.2048842560425, 416.1417318320227], "TKT1": [1091.8566418089445, 389.7734743173548], "TALA": [1089.7996310791666, 486.01846145691513], "TPI": [583.5485022453645, 469.1633005102476], "G3PD2": [510.2381761351399, 529.797043570699], "G3PD5": [416.7931911040246, 528.2527333280328], "GLYK": [480.05139851024757, 700.1591028462601], "PGK": [725.8690286587063, 659.869905691148], "GAPD": [723.3890412991506, 547.4904317858089], "PGM": [724.3434862289284, 771.0901991475978], "ENO": [716.1449606980399, 837.6203684489354], "EDA": [1208.5814383337065, 707.6966891728247], "EDD": [1298.208636787901, 134.57678315518075], "PPC": [585.4538606299093, 888.0826602499734], "PPCK": [506.14056624779505, 1001.0351352707742], "PYK": [582.1521588525361, 954.2800876178538], "PPS": [721.2877980448692, 983.052580597416], "MGSA": [1258.5806234762415, 897.5927306580032], "GLYOX3": [1396.107040387351, 1006.750917574431], "LDH_D": [983.3596204605552, 995.7912360036199], "FHL": [1099.028509016391, 1061.8153138386544], "PFL": [848.1844100660331, 1100.7730140470476], "ME2": [505.90206306421794, 1079.6234254550775], "ME1": [497.1020605744368, 1128.8382101492366], "PDH": [605.4344022485211, 1202.555772108724], "POX": [1016.106792985371, 1186.007108026973], "PTAr": [901.6973519642072, 1234.1705518233211], "ACALD": [959.4002271890231, 1291.5422182521518], "ACKr": [1276.6779516397437, 1241.7549505375548], "ALCD2x": [1283.082569211276, 1292.3715817623706], "CS": [713.5981715407237, 1335.0558317728], "SUCCt2_2pp": [290.4983208391389, 1827.289613935825], "SUCCt3pp": [429.06151953377383, 1911.5793448908814], "SUCDi": [397.032320720033, 1821.9532815963955], "FRD2": [510.19558998912385, 1804.6566278319117], "FUM": [397.3822001983073, 1706.9679574616653], "MDH": [419.220814493262, 1511.1103755131444], "MALS": [599.9215196667201, 1597.0875113380907], "SUCOAS": [813.2284954352816, 1923.7654366217896], "AKGDH": [1006.5635862075673, 1749.9729572067345], "ICL": [914.2742289259494, 1597.3761404495851], "ACONTa": [992.7604007313577, 1403.8717396765805], "ACONTb": [1040.3842724812498, 1513.5400891659026], "ICDHyr": [1044.4391520550744, 1609.2686499362178], "ADK1": [1379.7847132041616, 1391.360164542097], "ATPS4rpp": [1480.6471877737147, 1436.5704371047473], "CYTBO3_4pp": [1464.357342549, 1658.8532273467194], "NADH16pp": [1286.410114457017, 1688.6038842930952], "NADH17pp": [1451.7203278553177, 1723.8186967047777], "NADTRHD": [1265.645061942677, 1780.7150855994867], "THD2pp": [1485.131155498014, 1884.224538302543], "ATPM": [1307.3498448645007, 1506.788562549], "FORtex": [1392.0855475560004, 1123.6887413730003], "EX_h2_e": [1390.1368304560003, 1065.2272283730001], "Ec_biomass_iJO1366_core_53p95M": [1568.7172655000002, 619.6920378000001], "EX_h_e": [1636.9223640000002, 664.5125311000002], "EX_h2o_e": [1572.6146997000003, 721.0253270000001], "EX_co2_e": [1564.8198313000003, 793.1278597000002], "EX_glyc_e": [182.02884584981808, 759.4996671664823], "EX_glc_e": [147.039563, 100.97897699999999], "EX_succ_e": [119.36198234399868, 1873.2862873339993], "EX_ac_e": [1568.0352145150005, 1230.8486947020003]}, "view": "cnapy", "escher_map_data": ""}}
\ No newline at end of file
diff --git a/ECC2/map1.svg b/ECC2/map1.svg
index 81c58b5..fd612fa 100644
--- a/ECC2/map1.svg
+++ b/ECC2/map1.svg
@@ -1,15 +1,39 @@
 <?xml version="1.0" encoding="UTF-8" standalone="no"?>
 <svg
-   xmlns:dc="http://purl.org/dc/elements/1.1/"
-   xmlns:cc="http://creativecommons.org/ns#"
-   xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
-   xmlns:svg="http://www.w3.org/2000/svg"
-   xmlns="http://www.w3.org/2000/svg"
    viewBox="0 0 267 288"
    id="svg2"
    height="288mm"
    width="267mm"
-   version="1.0">
+   version="1.0"
+   sodipodi:docname="Original_ECC2_Map.svg"
+   inkscape:version="1.3.2 (091e20e, 2023-11-25, custom)"
+   xmlns:inkscape="http://www.inkscape.org/namespaces/inkscape"
+   xmlns:sodipodi="http://sodipodi.sourceforge.net/DTD/sodipodi-0.dtd"
+   xmlns="http://www.w3.org/2000/svg"
+   xmlns:svg="http://www.w3.org/2000/svg"
+   xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
+   xmlns:cc="http://creativecommons.org/ns#"
+   xmlns:dc="http://purl.org/dc/elements/1.1/">
+  <sodipodi:namedview
+     id="namedview1"
+     pagecolor="#505050"
+     bordercolor="#eeeeee"
+     borderopacity="1"
+     inkscape:showpageshadow="0"
+     inkscape:pageopacity="0"
+     inkscape:pagecheckerboard="0"
+     inkscape:deskcolor="#505050"
+     inkscape:document-units="mm"
+     inkscape:zoom="0.97571938"
+     inkscape:cx="590.84611"
+     inkscape:cy="890.11248"
+     inkscape:window-width="1920"
+     inkscape:window-height="986"
+     inkscape:window-x="-11"
+     inkscape:window-y="-11"
+     inkscape:window-maximized="1"
+     inkscape:current-layer="svg2"
+     showgrid="false" />
   <metadata
      id="metadata2755">
     <rdf:RDF>
@@ -18,7 +42,7 @@
         <dc:format>image/svg+xml</dc:format>
         <dc:type
            rdf:resource="http://purl.org/dc/dcmitype/StillImage" />
-        <dc:title></dc:title>
+        <dc:title />
       </cc:Work>
     </rdf:RDF>
   </metadata>
@@ -48,10 +72,6 @@
      id="path13"
      d="m 180.19042,152.35654 0,-0.21167 -2.18016,0 0,0.21167 2.18016,0 z"
      style="fill:#000000;fill-opacity:1;fill-rule:nonzero;stroke:none" />
-  <path
-     id="path15"
-     d="m 182.07426,150.11287 c 0,-0.10583 -0.0635,-0.14817 -0.254,-0.1905 -0.16934,-0.0212 -0.29634,-0.0847 -0.42334,-0.14817 l -0.0212,-0.0212 c 0.21166,-0.127 0.29633,-0.14817 0.48683,-0.1905 0.16933,-0.0212 0.21167,-0.0635 0.21167,-0.16934 0,-0.10583 -0.0635,-0.1905 -0.14817,-0.1905 -0.0635,0 -0.14817,0.0635 -0.254,0.1905 -0.10583,0.127 -0.21167,0.23284 -0.3175,0.27517 l -0.0212,0.0212 0,-0.10584 c 0,-0.10583 0.0212,-0.23283 0.0635,-0.381 0.0423,-0.0635 0.0635,-0.14816 0.0635,-0.1905 0,-0.0847 -0.0847,-0.16933 -0.16933,-0.16933 -0.0847,0 -0.14817,0.0635 -0.14817,0.16933 0,0.0423 0.0212,0.127 0.0423,0.21167 0.0423,0.14817 0.0635,0.27517 0.0635,0.40217 l 0,0.0635 c -0.16934,-0.10584 -0.254,-0.16934 -0.40217,-0.3175 -0.0847,-0.10584 -0.127,-0.14817 -0.1905,-0.14817 -0.0847,0 -0.16933,0.0635 -0.16933,0.14817 0,0.10583 0.10583,0.16933 0.3175,0.21166 0.14816,0.0423 0.27516,0.0847 0.35983,0.127 l 0.0635,0.0423 c -0.1905,0.10583 -0.254,0.127 -0.46567,0.16933 -0.1905,0.0423 -0.27516,0.0847 -0.27516,0.1905 0,0.10583 0.0635,0.16933 0.16933,0.16933 0.0635,0 0.10583,-0.0212 0.1905,-0.10583 0.127,-0.14817 0.14817,-0.16933 0.16933,-0.21167 0.0423,-0.0423 0.0847,-0.0635 0.23284,-0.14816 l 0,0.0212 0,0.0847 c 0.0212,0.0847 -0.0212,0.21167 -0.0635,0.35983 -0.0423,0.0847 -0.0635,0.16934 -0.0635,0.21167 0,0.0847 0.0847,0.16933 0.16933,0.16933 0.0847,0 0.16933,-0.0847 0.16933,-0.1905 0,-0.0212 -0.0212,-0.0847 -0.0423,-0.127 -0.0635,-0.16933 -0.0847,-0.33866 -0.0847,-0.508 l 0,-0.0212 0.0212,0.0212 c 0.10583,0.0212 0.1905,0.10584 0.3175,0.254 0.10583,0.127 0.1905,0.1905 0.254,0.1905 0.10583,0 0.14817,-0.0635 0.14817,-0.16933 z"
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      id="path17"
      d="m 185.37626,150.3457 c 0,-0.381 -0.127,-0.74083 -0.381,-0.97366 -0.29634,-0.29634 -0.762,-0.46567 -1.35467,-0.46567 l -1.18533,0 0,0.0847 c 0.33866,0.0423 0.381,0.0635 0.381,0.40216 l 0,1.94734 c 0,0.3175 -0.0423,0.381 -0.381,0.40216 l 0,0.0635 1.24883,0 c 0.48683,0 0.9525,-0.127 1.22767,-0.381 0.27516,-0.254 0.4445,-0.65616 0.4445,-1.0795 z m -0.46567,0.0423 c 0,0.508 -0.1905,0.889 -0.55033,1.0795 -0.21167,0.127 -0.46567,0.1905 -0.84667,0.1905 -0.16933,0 -0.23283,-0.0423 -0.23283,-0.1905 l 0,-2.2225 c 0,-0.127 0.0423,-0.16934 0.23283,-0.16934 0.381,0 0.65617,0.0635 0.86783,0.21167 0.33867,0.23283 0.52917,0.61383 0.52917,1.10067 z"
@@ -244,10 +264,6 @@
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      style="fill:#000000;fill-opacity:1;fill-rule:nonzero;stroke:none" />
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diff --git a/ECC2/meta.json b/ECC2/meta.json
index d35a35e..d6e7eb8 100644
--- a/ECC2/meta.json
+++ b/ECC2/meta.json
@@ -1 +1 @@
-{"description": "EColiCore2\nMetabolic core model of Escherichia coli str. K-12 substr. MG1655, derived from iJO1366 with MATLAB CellNetAnalyzer function CNAreduceMFNetwork. Contains minor changes with respect to parent model iJO1366. No GPR-rules included.\n\nContains:\n686 metabolites\n500 reactions\n\nPublication:\nH\u00e4dicke, O., Klamt, S. EColiCore2: a reference network model of the central metabolism of Escherichia coli and relationships to its genome-scale parent model. Sci Rep 7, 39647 (2017). https://doi.org/10.1038/srep39647", "format version": 1}
\ No newline at end of file
+{"format version": 2, "description": "ECC2 model (https://doi.org/10.1038/srep39647) with annotations from iJO1366 (https://doi.org/10.1038/msb.2011.65) and dG0 from eQuilibrator (https://doi.org/10.1093/nar/gkab1106) @ standard settings (pH 7.5 in cytosol, 7.0 elsewhere, and standard ionic strength of 250 mM and pMg of 2.5, and potential differences between compartments of -0.15 V)."}
\ No newline at end of file
diff --git a/ECC2/model.sbml b/ECC2/model.sbml
index 39c81ff..0dcb02c 100644
--- a/ECC2/model.sbml
+++ b/ECC2/model.sbml
@@ -11,499 +11,13805 @@
       </unitDefinition>
     </listOfUnitDefinitions>
     <listOfCompartments>
-      <compartment id="Internal_Species" constant="true"/>
+      <compartment id="c" constant="true"/>
+      <compartment id="e" constant="true"/>
+      <compartment id="p" constant="true"/>
     </listOfCompartments>
     <listOfSpecies>
-      <species id="M_10fthf_c" name="10-Formyltetrahydrofolate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_13dpg_c" name="3-Phospho-D-glyceroylphosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_1hdec9eg3p_c" name="1-hexadec-9-enoyl-sn-glycerol3-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_1hdecg3p_c" name="1-hexadecanoyl-sn-glycerol3-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_1pyr5c_c" name="1-Pyrroline-5-carboxylate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_23dhdp_c" name="2,3-Dihydrodipicolinate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_23dhmb_c" name="(R)-2,3-Dihydroxy-3-methylbutanoate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_23dhmp_c" name="(R)-2,3-Dihydroxy-3-methylpentanoate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_25aics_c" name="(S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_25drapp_c" name="2,5-Diamino-6-(ribosylamino)-4-(3H)-pyrimidinone5#-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_26dap__LL_c" name="LL-2,6-Diaminoheptanedioate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_26dap__M_c" name="meso-2,6-Diaminoheptanedioate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_2ahbut_c" name="(S)-2-Aceto-2-hydroxybutanoate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_2cpr5p_c" name="1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose5-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_2dda7p_c" name="2-Dehydro-3-deoxy-D-arabino-heptonate7-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_2ddg6p_c" name="2-Dehydro-3-deoxy-D-gluconate6-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_2dhp_c" name="2-Dehydropantoate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_2dmmq8_c" name="2-Demethylmenaquinone8" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_2dmmql8_c" name="2-Demethylmenaquinol8" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_2dr1p_c" name="2-Deoxy-D-ribose1-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_2fe1s_c" name="[2Fe-1S]desulfuratediron-sulfurcluster" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_2fe2s_c" name="[2Fe-2S]iron-sulfurcluster" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_2h3oppan_c" name="2-Hydroxy-3-oxopropanoate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_2ippm_c" name="2-Isopropylmaleate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_2mahmp_c" name="2-Methyl-4-amino-5-hydroxymethylpyrimidinediphosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_2me4p_c" name="2-C-methyl-D-erythritol4-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_2mecdp_c" name="2-C-methyl-D-erythritol2,4-cyclodiphosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_2obut_c" name="2-Oxobutanoate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_2ohph_c" name="2-Octaprenyl-6-hydroxyphenol" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_2oph_c" name="2-Octaprenylphenol" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_2p4c2me_c" name="2-phospho-4-(cytidine5#-diphospho)-2-C-methyl-D-erythritol" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_2pg_c" name="D-Glycerate2-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_34hpp_c" name="3-(4-Hydroxyphenyl)pyruvate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_3c2hmp_c" name="3-Carboxy-2-hydroxy-4-methylpentanoate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_3c3hmp_c" name="3-Carboxy-3-hydroxy-4-methylpentanoate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_3c4mop_c" name="3-Carboxy-4-methyl-2-oxopentanoate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_3dhq_c" name="3-Dehydroquinate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_3dhsk_c" name="3-Dehydroshikimate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_3hbcoa_c" name="(S)-3-Hydroxybutanoyl-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_3hdcoa_c" name="(S)-3-Hydroxydecanoyl-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_3hddcoa_c" name="(S)-3-Hydroxydodecanoyl-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_3hhcoa_c" name="(S)-3-Hydroxyhexanoyl-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_3hhdcoa_c" name="(S)-3-Hydroxyhexadecanoyl-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_3hmrsACP_c" name="(R)-3-Hydroxytetradecanoyl-[acyl-carrierprotein]" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_3hocoa_c" name="(S)-3-Hydroxyoctanoyl-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_3htdcoa_c" name="(S)-3-Hydroxytetradecanoyl-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_3ig3p_c" name="C#-(3-Indolyl)-glycerol3-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_3mob_c" name="3-Methyl-2-oxobutanoate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_3mop_c" name="(S)-3-Methyl-2-oxopentanoate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_3odcoa_c" name="3-Oxodecanoyl-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_3oddcoa_c" name="3-Oxododecanoyl-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_3ohcoa_c" name="3-Oxohexanoyl-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_3ohdcoa_c" name="3-Oxohexadecanoyl-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_3omrsACP_c" name="3-Oxotetradecanoyl-[acyl-carrierprotein]" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_3oocoa_c" name="3-Oxooctanoyl-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_3ophb_c" name="3-Octaprenyl-4-hydroxybenzoate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_3otdcoa_c" name="3-Oxotetradecanoyl-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_3pg_c" name="3-Phospho-D-glycerate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_3php_c" name="3-Phosphohydroxypyruvate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_3psme_c" name="5-O-(1-Carboxyvinyl)-3-phosphoshikimate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_4abz_c" name="4-Aminobenzoate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_4adcho_c" name="4-amino-4-deoxychorismate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_4ampm_c" name="4-Amino-2-methyl-5-phosphomethylpyrimidine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_4c2me_c" name="4-(cytidine5#-diphospho)-2-C-methyl-D-erythritol" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_4crsol_c" name="p-Cresol" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_4fe4s_c" name="[4Fe-4S]iron-sulfurcluster" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_4hbz_c" name="4-Hydroxybenzoate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_4mop_c" name="4-Methyl-2-oxopentanoate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_4mpetz_c" name="4-Methyl-5-(2-phosphoethyl)-thiazole" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_4pasp_c" name="4-Phospho-L-aspartate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_4per_c" name="4-Phospho-D-erythronate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_4ppan_c" name="D-4#-Phosphopantothenate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_4ppcys_c" name="N-((R)-4-Phosphopantothenoyl)-L-cysteine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_4r5au_c" name="4-(1-D-Ribitylamino)-5-aminouracil" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_5aizc_c" name="5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_5aop_c" name="5-Amino-4-oxopentanoate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_5aprbu_c" name="5-Amino-6-(5#-phosphoribitylamino)uracil" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_5apru_c" name="5-Amino-6-(5#-phosphoribosylamino)uracil" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_5caiz_c" name="5-phosphoribosyl-5-carboxyaminoimidazole" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_5drib_c" name="5#-deoxyribose" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_5mthf_c" name="5-Methyltetrahydrofolate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_6hmhpt_c" name="6-hydroxymethyldihydropterin" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_6hmhptpp_c" name="6-hydroxymethyl-dihydropterinpyrophosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_6pgc_c" name="6-Phospho-D-gluconate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_6pgl_c" name="6-phospho-D-glucono-1,5-lactone" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_8aonn_c" name="8-Amino-7-oxononanoate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_ACP_c" name="acylcarrierprotein" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_aacoa_c" name="Acetoacetyl-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_ac_c" name="Acetate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_acald_c" name="Acetaldehyde" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_accoa_c" name="Acetyl-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_acg5p_c" name="N-Acetyl-L-glutamyl5-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_acg5sa_c" name="N-Acetyl-L-glutamate5-semialdehyde" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_acgam1p_c" name="N-Acetyl-D-glucosamine1-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_acglu_c" name="N-Acetyl-L-glutamate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_acon__C_c" name="cis-Aconitate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_acorn_c" name="N2-Acetyl-L-ornithine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_acser_c" name="O-Acetyl-L-serine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_actp_c" name="Acetylphosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_ade_c" name="Adenine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_adn_c" name="Adenosine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_adp_c" name="ADP" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_ahcys_c" name="S-Adenosyl-L-homocysteine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_ahdt_c" name="2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridinetriphosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_aicar_c" name="5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_air_c" name="5-amino-1-(5-phospho-D-ribosyl)imidazole" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_akg_c" name="2-Oxoglutarate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_ala__B_c" name="beta-Alanine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_ala__D_c" name="D-Alanine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_ala__L_c" name="L-Alanine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_alaala_c" name="D-Alanyl-D-alanine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_alac__S_c" name="(S)-2-Acetolactate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_amet_c" name="S-Adenosyl-L-methionine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_amob_c" name="S-Adenosyl-4-methylthio-2-oxobutanoate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_amp_c" name="AMP" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_anth_c" name="Anthranilate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_aps_c" name="Adenosine5#-phosphosulfate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_ara5p_c" name="D-Arabinose5-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_arg__L_c" name="L-Arginine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_argsuc_c" name="N(omega)-(L-Arginino)succinate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_asn__L_c" name="L-Asparagine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_asp__L_c" name="L-Aspartate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_aspsa_c" name="L-Aspartate4-semialdehyde" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_atp_c" name="ATP" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_b2coa_c" name="Crotonoyl-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_bmoco_c" name="bis-molybdenumcofactor" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_bmoco1gdp_c" name="bis-molybdopterinmono-guaninedinucleotide" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_bmocogdp_c" name="bis-molybdopteringuaninedinucleotide" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_btcoa_c" name="Butanoyl-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_btn_c" name="Biotin" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_ca2_c" name="Calcium" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_cbasp_c" name="N-Carbamoyl-L-aspartate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_cbp_c" name="Carbamoylphosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_cdp_c" name="CDP" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_cdpdhdec9eg_c" name="CDP-1,2-dihexadec-9-enoylglycerol" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_cdpdhdecg_c" name="CDP-1,2-dihexadecanoylglycerol" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_chor_c" name="chorismate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_cit_c" name="Citrate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_citr__L_c" name="L-Citrulline" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_ckdo_c" name="CMP-3-deoxy-D-manno-octulosonate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_cl_c" name="Chloride" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_cmp_c" name="CMP" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_co2_c" name="CO2" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_coa_c" name="CoenzymeA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_cobalt2_c" name="Co2+" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_cpmp_c" name="cyclicpyranopterinmonophosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_cpppg3_c" name="CoproporphyrinogenIII" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_ctp_c" name="CTP" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_cu2_c" name="Cu2+" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_cys__L_c" name="L-Cysteine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_cyst__L_c" name="L-Cystathionine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_dad__2_c" name="Deoxyadenosine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_dad__5_c" name="5#-Deoxyadenosine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_dadp_c" name="dADP" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_damp_c" name="dAMP" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_dann_c" name="7,8-Diaminononanoate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_datp_c" name="dATP" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_db4p_c" name="3,4-dihydroxy-2-butanone4-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_dc2coa_c" name="trans-Dec-2-enoyl-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_dcacoa_c" name="Decanoyl-CoA(n-C10:0CoA)" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_dcamp_c" name="N6-(1,2-Dicarboxyethyl)-AMP" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_dctp_c" name="dCTP" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_dd2coa_c" name="trans-Dodec-2-enoyl-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_ddca_c" name="Dodecanoate(n-C12:0)" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_ddcaACP_c" name="Dodecanoyl-ACP(n-C12:0ACP)" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_ddcacoa_c" name="Dodecanoyl-CoA(n-C12:0CoA)" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_dgtp_c" name="dGTP" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_dha_c" name="Dihydroxyacetone" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_dhap_c" name="Dihydroxyacetonephosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_dhf_c" name="7,8-Dihydrofolate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_dhgly_c" name="dehydroglycine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_dhnpt_c" name="Dihydroneopterin" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_dhor__S_c" name="(S)-Dihydroorotate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_dhpmp_c" name="Dihydroneopterinmonophosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_dhpt_c" name="Dihydropteroate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_dhptd_c" name="4,5-dihydroxy-2,3-pentanedione" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_dmlz_c" name="6,7-Dimethyl-8-(1-D-ribityl)lumazine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_dmpp_c" name="Dimethylallyldiphosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_dnad_c" name="Deamino-NAD+" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_dpcoa_c" name="Dephospho-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_dscl_c" name="dihydrosirohydrochlorin" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_dtbt_c" name="Dethiobiotin" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_dtdp_c" name="dTDP" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_dtmp_c" name="dTMP" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_dttp_c" name="dTTP" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_dump_c" name="dUMP" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_duri_c" name="Deoxyuridine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_dxyl5p_c" name="1-deoxy-D-xylulose5-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_e4p_c" name="D-Erythrose4-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_egmeACP_c" name="Enoylglutaryl-[acyl-carrierprotein]methylester" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_eig3p_c" name="D-erythro-1-(Imidazol-4-yl)glycerol3-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_epmeACP_c" name="Enoylpimeloyl-[acyl-carrierprotein]methylester" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_etoh_c" name="Ethanol" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_f6p_c" name="D-Fructose6-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_fad_c" name="Flavinadeninedinucleotideoxidized" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_fadh2_c" name="Flavinadeninedinucleotidereduced" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_fdp_c" name="D-Fructose1,6-bisphosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_fe2_c" name="Fe2+" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_fe3_c" name="Fe3+" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_fgam_c" name="N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_flxr_c" name="Flavodoxinreduced" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_flxso_c" name="flavodoxinsemioxidized" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_fmn_c" name="FMN" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_for_c" name="Formate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_fpram_c" name="2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_fprica_c" name="5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_frdp_c" name="Farnesyldiphosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_fum_c" name="Fumarate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_g3p_c" name="Glyceraldehyde3-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_g6p_c" name="D-Glucose6-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_gam1p_c" name="D-Glucosamine1-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_gam6p_c" name="D-Glucosamine6-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_gar_c" name="N1-(5-Phospho-D-ribosyl)glycinamide" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_gcald_c" name="Glycolaldehyde" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_gdp_c" name="GDP" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_glc__D_c" name="D-Glucose" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_gln__L_c" name="L-Glutamine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_glu__D_c" name="D-Glutamate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_glu__L_c" name="L-Glutamate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_glu1sa_c" name="L-Glutamate1-semialdehyde" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_glu5p_c" name="L-Glutamate5-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_glu5sa_c" name="L-Glutamate5-semialdehyde" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_glutrna_c" name="L-Glutamyl-tRNA(Glu)" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_glx_c" name="Glyoxylate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_gly_c" name="Glycine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_glyc_c" name="Glycerol" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_glyc__R_c" name="(R)-Glycerate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_glyc3p_c" name="Glycerol3-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_glyclt_c" name="Glycolate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_gmeACP_c" name="Glutaryl-[acyl-carrierprotein]methylester" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_gmp_c" name="GMP" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_grdp_c" name="Geranyldiphosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_grxox_c" name="glutaredoxin(oxidized)" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_grxrd_c" name="glutaredoxin(reduced)" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_gthox_c" name="Oxidizedglutathione" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_gthrd_c" name="Reducedglutathione" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_gtp_c" name="GTP" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_h_c" name="H+" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_h2_c" name="H2" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_h2mb4p_c" name="1-hydroxy-2-methyl-2-(E)-butenyl4-diphosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_h2o_c" name="H2O" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_h2s_c" name="Hydrogensulfide" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_hco3_c" name="Bicarbonate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_hcys__L_c" name="L-Homocysteine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_hdca_c" name="Hexadecanoate(n-C16:0)" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_hdcap_c" name="Hexadecanoyl-phosphate(n-C16:0)" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_hdcea_c" name="Hexadecenoate(n-C16:1)" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_hdceap_c" name="Hexadecanoyl-phosphate(n-C16:1)" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_hdcoa_c" name="Hexadecenoyl-CoA(n-C16:1CoA)" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_hdd2coa_c" name="trans-Hexadec-2-enoyl-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_hdeACP_c" name="cis-hexadec-9-enoyl-[acyl-carrierprotein](n-C16:1)" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
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-      <species id="M_his__L_c" name="L-Histidine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_hisp_c" name="L-Histidinolphosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_histd_c" name="L-Histidinol" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_hmbil_c" name="Hydroxymethylbilane" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_hom__L_c" name="L-Homoserine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_hpmeACP_c" name="3-Hydroxypimeloyl-[acyl-carrierprotein]methylester" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_hx2coa_c" name="trans-Hex-2-enoyl-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_hxcoa_c" name="Hexanoyl-CoA(n-C6:0CoA)" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_iasp_c" name="Iminoaspartate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_icit_c" name="Isocitrate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_ile__L_c" name="L-Isoleucine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_imacp_c" name="3-(Imidazol-4-yl)-2-oxopropylphosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_imp_c" name="IMP" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_indole_c" name="Indole" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_ipdp_c" name="Isopentenyldiphosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_iscs_c" name="IscSsulfuracceptorprotein" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_iscssh_c" name="IscSwithboundsulfur" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_iscu_c" name="IscUscaffoldprotein" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
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-      <species id="M_k_c" name="potassium" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_kdo_c" name="3-Deoxy-D-manno-2-octulosonate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_kdo2lipid4_c" name="KDO(2)-lipidIV(A)" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_kdo8p_c" name="3-Deoxy-D-manno-octulosonate8-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_kdolipid4_c" name="KDO-lipidIV(A)" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_lac__D_c" name="D-Lactate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_leu__L_c" name="L-Leucine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
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-      <species id="M_lipidAds_c" name="LipidADisaccharide" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_lipidX_c" name="2,3-Bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl1-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
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-      <species id="M_mal__L_c" name="L-Malate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_malACP_c" name="Malonyl-[acyl-carrierprotein]" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_malcoa_c" name="Malonyl-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_malcoame_c" name="malonyl-CoAmethylester" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_mdhdhf_c" name="(2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
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-      <species id="M_met__L_c" name="L-Methionine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_methf_c" name="5,10-Methenyltetrahydrofolate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_mg2_c" name="magnesium" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_mlthf_c" name="5,10-Methylenetetrahydrofolate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_mn2_c" name="Mn2+" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_moadamp_c" name="MoaDProteinwithboundAMP" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_moadcoo_c" name="MoaDProteinwithcarboxylate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_moadcosh_c" name="MoaDProteinwiththiocarboxylate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_mobd_c" name="Molybdate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_moco_c" name="molybdenumcofactor" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
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-      <species id="M_mptamp_c" name="adenylatedmolybdopterin" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_mql8_c" name="Menaquinol8" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_mqn8_c" name="Menaquinone8" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_mthgxl_c" name="Methylglyoxal" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_mththf_c" name="(2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_na1_c" name="Sodium" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_nad_c" name="Nicotinamideadeninedinucleotide" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
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-      <species id="M_nadp_c" name="Nicotinamideadeninedinucleotidephosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
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-      <species id="M_nh4_c" name="Ammonium" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_ni2_c" name="nickel" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_nicrnt_c" name="NicotinateD-ribonucleotide" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_o2_c" name="O2" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_oaa_c" name="Oxaloacetate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_oc2coa_c" name="trans-Oct-2-enoyl-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
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-      <species id="M_octdp_c" name="all-trans-Octaprenyldiphosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_ogmeACP_c" name="3-Oxo-glutaryl-[acyl-carrierprotein]methylester" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
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-      <species id="M_orot_c" name="Orotate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_orot5p_c" name="Orotidine5#-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_pa160_c" name="1,2-dihexadecanoyl-sn-glycerol3-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_pa161_c" name="1,2-dihexadec-9-enoyl-sn-glycerol3-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
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-      <species id="M_pan4p_c" name="Pantetheine4#-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_pant__R_c" name="(R)-Pantoate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_pap_c" name="Adenosine3#,5#-bisphosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_paps_c" name="3#-Phosphoadenylylsulfate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_pdx5p_c" name="Pyridoxine5#-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_pe160_c" name="phosphatidylethanolamine(dihexadecanoyl,n-C16:0)" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
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-      <species id="M_pep_c" name="Phosphoenolpyruvate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_phe__L_c" name="L-Phenylalanine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_pheme_c" name="Protoheme" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
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-      <species id="M_phpyr_c" name="Phenylpyruvate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
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-      <species id="M_pi_c" name="Phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_pimACP_c" name="Pimeloyl-[acyl-carrierprotein]" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_pmeACP_c" name="Pimeloyl-[acyl-carrierprotein]methylester" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
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-      <species id="M_pnto__R_c" name="(R)-Pantothenate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_ppbng_c" name="Porphobilinogen" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_pphn_c" name="Prephenate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_ppi_c" name="Diphosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_ppp9_c" name="Protoporphyrin" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_pppg9_c" name="ProtoporphyrinogenIX" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_pram_c" name="5-Phospho-beta-D-ribosylamine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_pran_c" name="N-(5-Phospho-D-ribosyl)anthranilate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_prbamp_c" name="1-(5-Phosphoribosyl)-AMP" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_prbatp_c" name="1-(5-Phosphoribosyl)-ATP" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_prfp_c" name="1-(5-Phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
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-      <species id="M_pro__L_c" name="L-Proline" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_prpp_c" name="5-Phospho-alpha-D-ribose1-diphosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_ps160_c" name="phosphatidylserine(dihexadecanoyl,n-C16:0)" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_ps161_c" name="phosphatidylserine(dihexadec-9-enoyl,n-C16:1)" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_pser__L_c" name="O-Phospho-L-serine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_pydx5p_c" name="Pyridoxal5#-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_pyr_c" name="Pyruvate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_q8_c" name="Ubiquinone-8" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_q8h2_c" name="Ubiquinol-8" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_quln_c" name="Quinolinate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_r1p_c" name="alpha-D-Ribose1-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_r5p_c" name="alpha-D-Ribose5-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_rhcys_c" name="S-Ribosyl-L-homocysteine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_ribflv_c" name="Riboflavin" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_ru5p__D_c" name="D-Ribulose5-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_s7p_c" name="Sedoheptulose7-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_scl_c" name="sirohydrochlorin" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_ser__L_c" name="L-Serine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_sheme_c" name="Siroheme" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_skm_c" name="Shikimate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_skm5p_c" name="Shikimate5-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_sl26da_c" name="N-Succinyl-LL-2,6-diaminoheptanedioate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_sl2a6o_c" name="N-Succinyl-2-L-amino-6-oxoheptanedioate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_so3_c" name="Sulfite" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_so4_c" name="Sulfate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_succ_c" name="Succinate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_succoa_c" name="Succinyl-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_suchms_c" name="O-Succinyl-L-homoserine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_td2coa_c" name="trans-Tetradec-2-enoyl-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_tdcoa_c" name="Tetradecanoyl-CoA(n-C14:0CoA)" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_thdp_c" name="2,3,4,5-Tetrahydrodipicolinate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_thf_c" name="5,6,7,8-Tetrahydrofolate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_thmmp_c" name="Thiaminmonophosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_thmpp_c" name="Thiaminediphosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_thr__L_c" name="L-Threonine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_trnaglu_c" name="tRNA(Glu)" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_trp__L_c" name="L-Tryptophan" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_tyr__L_c" name="L-Tyrosine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
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-      <species id="M_u3aga_c" name="UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
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-      <species id="M_udcpdp_c" name="Undecaprenyldiphosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_udcpp_c" name="Undecaprenylphosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
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-      <species id="M_uppg3_c" name="UroporphyrinogenIII" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
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-      <species id="M_xmp_c" name="Xanthosine5#-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
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-      <species id="M_co2_e" name="CO2" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_cobalt2_e" name="Co2+" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_cu2_e" name="Cu2+" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_etoh_e" name="Ethanol" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_fe2_e" name="Fe2+" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_fe3_e" name="Fe3+" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_for_e" name="Formate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
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-      <species id="M_glyc_e" name="Glycerol" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_h_e" name="H+" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
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-      <species id="M_k_e" name="potassium" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_kdo2lipid4_e" name="KDO(2)-lipidIV(A)" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
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-      <species id="M_mn2_e" name="Mn2+" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_mobd_e" name="Molybdate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_nh4_e" name="Ammonium" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
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-      <species id="M_forBIO_c" name="M_forBIO_c" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
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+        <annotation>
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+            <rdf:Description rdf:about="#meta_M_23dhmp_c">
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+        <annotation>
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+        <annotation>
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+      <species metaid="meta_M_2p4c2me_c" sboTerm="SBO:0000247" id="M_2p4c2me_c" name="2-phospho-4-(cytidine 5&apos;-diphospho)-2-C-methyl-D-erythritol" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
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+        <annotation>
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+        <annotation>
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+      <species metaid="meta_M_5aprbu_c" sboTerm="SBO:0000247" id="M_5aprbu_c" name="5-Amino-6-(5&apos;-phosphoribitylamino)uracil" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
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+            <rdf:Description rdf:about="#meta_M_5aprbu_c">
+              <bqbiol:is>
+                <rdf:Bag>
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+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:2031"/>
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+        </annotation>
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+      <species metaid="meta_M_5apru_c" sboTerm="SBO:0000247" id="M_5apru_c" name="5-Amino-6-(5&apos;-phosphoribosylamino)uracil" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
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+            <rdf:Description rdf:about="#meta_M_5apru_c">
+              <bqbiol:is>
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+      <species metaid="meta_M_5caiz_c" sboTerm="SBO:0000247" id="M_5caiz_c" name="5-phosphoribosyl-5-carboxyaminoimidazole" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
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+            <rdf:Description rdf:about="#meta_M_5caiz_c">
+              <bqbiol:is>
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+      <species metaid="meta_M_5drib_c" sboTerm="SBO:0000247" id="M_5drib_c" name="5&apos;-deoxyribose" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
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+            <rdf:Description rdf:about="#meta_M_5drib_c">
+              <bqbiol:is>
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+      <species metaid="meta_M_5mthf_c" sboTerm="SBO:0000247" id="M_5mthf_c" name="5-Methyltetrahydrofolate" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
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+            <rdf:Description rdf:about="#meta_M_5mthf_c">
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+        </annotation>
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+        <annotation>
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+        <annotation>
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+        <annotation>
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+            <rdf:Description rdf:about="#meta_M_ahdt_c">
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+        <annotation>
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+        <annotation>
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+            <rdf:Description rdf:about="#meta_M_air_c">
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+        <annotation>
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+            <rdf:Description rdf:about="#meta_M_akg_c">
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+      <species metaid="meta_M_ala__D_c" sboTerm="SBO:0000247" id="M_ala__D_c" name="D-Alanine" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_M_ala__D_c">
+              <bqbiol:is>
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+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:D-ALANINE"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:12899"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00117"/>
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+        <annotation>
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+        <annotation>
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+      <species metaid="meta_M_amet_c" sboTerm="SBO:0000247" id="M_amet_c" name="S-Adenosyl-L-methionine" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
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+            <rdf:Description rdf:about="#meta_M_amet_c">
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+        <annotation>
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+            <rdf:Description rdf:about="#meta_M_amob_c">
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+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:S-ADENOSYL-4-METHYLTHIO-2-OXOBUTANOATE"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:12758"/>
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+        </annotation>
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+      <species metaid="meta_M_amp_c" sboTerm="SBO:0000247" id="M_amp_c" name="AMP C10H12N5O7P" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
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+            <rdf:Description rdf:about="#meta_M_amp_c">
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+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:AMP-GROUP"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/inchi_key/UDMBCSSLTHHNCD-KQYNXXCUSA-L"/>
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+      <species metaid="meta_M_anth_c" sboTerm="SBO:0000247" id="M_anth_c" name="Anthranilate" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
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+            <rdf:Description rdf:about="#meta_M_anth_c">
+              <bqbiol:is>
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+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:ANTHRANILATE"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:30754"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00108"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/5005"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00093"/>
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+      <species metaid="meta_M_aps_c" sboTerm="SBO:0000247" id="M_aps_c" name="Adenosine 5&apos;-phosphosulfate" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
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+            <rdf:Description rdf:about="#meta_M_aps_c">
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+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:APS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:22247"/>
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+        </annotation>
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+        <annotation>
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+        <annotation>
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+        <annotation>
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+      <species metaid="meta_M_cbasp_c" sboTerm="SBO:0000247" id="M_cbasp_c" name="N-Carbamoyl-L-aspartate" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
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+        </annotation>
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+      <species metaid="meta_M_cbp_c" sboTerm="SBO:0000247" id="M_cbp_c" name="Carbamoyl phosphate" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
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+            <rdf:Description rdf:about="#meta_M_cbp_c">
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+      <species metaid="meta_M_cdp_c" sboTerm="SBO:0000247" id="M_cdp_c" name="CDP C9H12N3O11P2" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
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+            <rdf:Description rdf:about="#meta_M_cdp_c">
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+        <annotation>
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+            <rdf:Description rdf:about="#meta_M_cdpdhdec9eg_c">
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+                  <rdf:li rdf:resource="https://identifiers.org/inchi_key/LBKBJHVQQNUXGQ-BQUKFSKHSA-L"/>
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+      <species metaid="meta_M_cdpdhdecg_c" sboTerm="SBO:0000247" id="M_cdpdhdecg_c" name="CDP-1,2-dihexadecanoylglycerol" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
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+            <rdf:Description rdf:about="#meta_M_cdpdhdecg_c">
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+        </annotation>
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+        <annotation>
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+      <species metaid="meta_M_ddca_c" sboTerm="SBO:0000247" id="M_ddca_c" name="Dodecanoate (n-C12:0)" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
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+            <rdf:Description rdf:about="#meta_M_ddca_c">
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+      <species metaid="meta_M_ddcaACP_c" sboTerm="SBO:0000247" id="M_ddcaACP_c" name="Dodecanoyl-ACP (n-C12:0ACP)" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
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+            <rdf:Description rdf:about="#meta_M_ddcaACP_c">
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+        <annotation>
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+        <annotation>
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+        <annotation>
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+            <rdf:Description rdf:about="#meta_M_dhor__S_c">
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+      <species metaid="meta_M_dhpmp_c" sboTerm="SBO:0000247" id="M_dhpmp_c" name="Dihydroneopterin monophosphate" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
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+            <rdf:Description rdf:about="#meta_M_dhpmp_c">
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+      <species metaid="meta_M_dhpt_c" sboTerm="SBO:0000247" id="M_dhpt_c" name="Dihydropteroate" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
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+            <rdf:Description rdf:about="#meta_M_dhpt_c">
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+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:23762"/>
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+      <species metaid="meta_M_dhptd_c" sboTerm="SBO:0000247" id="M_dhptd_c" name="4,5-dihydroxy-2,3-pentanedione" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
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+            <rdf:Description rdf:about="#meta_M_dhptd_c">
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+        </annotation>
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+      <species metaid="meta_M_dmlz_c" sboTerm="SBO:0000247" id="M_dmlz_c" name="6,7-Dimethyl-8-(1-D-ribityl)lumazine" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
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+        <annotation>
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+        <annotation>
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+        <annotation>
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+        <annotation>
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+        <annotation>
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+        <annotation>
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+      <species metaid="meta_M_hdcoa_c" sboTerm="SBO:0000247" id="M_hdcoa_c" name="Hexadecenoyl-CoA (n-C16:1CoA)" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
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+      <species metaid="meta_M_hdd2coa_c" sboTerm="SBO:0000247" id="M_hdd2coa_c" name="Trans-Hexadec-2-enoyl-CoA" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
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+        </annotation>
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+      <species metaid="meta_M_hdeACP_c" sboTerm="SBO:0000247" id="M_hdeACP_c" name="Cis-hexadec-9-enoyl-[acyl-carrier protein] (n-C16:1)" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
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+            <rdf:Description rdf:about="#meta_M_hdeACP_c">
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+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM89949"/>
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+        </annotation>
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+      <species metaid="meta_M_hgmeACP_c" sboTerm="SBO:0000247" id="M_hgmeACP_c" name="3-Hydroxyglutaryl-[acyl-carrier protein] methyl ester" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
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+            <rdf:Description rdf:about="#meta_M_hgmeACP_c">
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+      <species metaid="meta_M_his__L_c" sboTerm="SBO:0000247" id="M_his__L_c" name="L-Histidine" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
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+            <rdf:Description rdf:about="#meta_M_his__L_c">
+              <bqbiol:is>
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+                  <rdf:li rdf:resource="https://identifiers.org/reactome.compound/379695"/>
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+        </annotation>
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+      <species metaid="meta_M_hisp_c" sboTerm="SBO:0000247" id="M_hisp_c" name="L-Histidinol phosphate" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
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+            <rdf:Description rdf:about="#meta_M_hisp_c">
+              <bqbiol:is>
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+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:L-HISTIDINOL-P"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:16996"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00807"/>
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+        </annotation>
+      </species>
+      <species metaid="meta_M_histd_c" sboTerm="SBO:0000247" id="M_histd_c" name="L-Histidinol" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_M_histd_c">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/histd"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:HISTIDINOL"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13118"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:57699"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/inchi_key/ZQISRDCJNBUVMM-YFKPBYRVSA-O"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00860"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM1281"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/5283"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00641"/>
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+        </annotation>
+      </species>
+      <species metaid="meta_M_hmbil_c" sboTerm="SBO:0000247" id="M_hmbil_c" name="Hydroxymethylbilane" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_M_hmbil_c">
+              <bqbiol:is>
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+                  <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/hmbil"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:HYDROXYMETHYLBILANE"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:14423"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:5809"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:16645"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/inchi_key/WDFJYRZCZIUBPR-UHFFFAOYSA-F"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C01024"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM547"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.compound/189449"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/5362"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00755"/>
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+        </annotation>
+      </species>
+      <species metaid="meta_M_hom__L_c" sboTerm="SBO:0000247" id="M_hom__L_c" name="L-Homoserine" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
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+            <rdf:Description rdf:about="#meta_M_hom__L_c">
+              <bqbiol:is>
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+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:57476"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB00719"/>
+                  <rdf:li rdf:resource="https://identifiers.org/inchi_key/UKAUYVFTDYCKQA-VKHMYHEASA-N"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00263"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM353"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/2001"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00227"/>
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+        </annotation>
+      </species>
+      <species metaid="meta_M_hpmeACP_c" sboTerm="SBO:0000247" id="M_hpmeACP_c" name="3-Hydroxypimeloyl-[acyl-carrier protein] methyl ester" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_M_hpmeACP_c">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/hpmeACP"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:3-hydroxypimeloyl-ACP-methyl-esters"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C20377"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM10038"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd22065"/>
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+              </bqbiol:is>
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+        </annotation>
+      </species>
+      <species metaid="meta_M_hx2coa_c" sboTerm="SBO:0000247" id="M_hx2coa_c" name="Trans-Hex-2-enoyl-CoA" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
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+        <annotation>
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+            <rdf:Description rdf:about="#meta_M_indole_c">
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+            <rdf:Description rdf:about="#meta_M_iscssh_c">
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+      <species metaid="meta_M_iscu_c" sboTerm="SBO:0000247" id="M_iscu_c" name="IscU scaffold protein" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
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+            <rdf:Description rdf:about="#meta_M_iscu_c">
+              <bqbiol:is>
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+                  <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/iscu"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM147128"/>
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+              </bqbiol:is>
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+      <species id="M_iscu__2fe2s2_c" name="IscUwithtwobound[2Fe-2S]clusters" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_iscu__4fe4s_c" name="IscUwithbound[4Fe-4S]cluster" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species metaid="meta_M_k_c" sboTerm="SBO:0000247" id="M_k_c" name="Potassium" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
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+            <rdf:Description rdf:about="#meta_M_k_c">
+              <bqbiol:is>
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+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:K+"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:26219"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00205"/>
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+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+      </species>
+      <species metaid="meta_M_kdo_c" sboTerm="SBO:0000247" id="M_kdo_c" name="3-Deoxy-D-manno-2-octulosonate" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
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+            <rdf:Description rdf:about="#meta_M_kdo_c">
+              <bqbiol:is>
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+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:KDO"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:43577"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:85986"/>
+                  <rdf:li rdf:resource="https://identifiers.org/inchi_key/NNLZBVFSCVTSLA-HXUQBWEZSA-M"/>
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+              </bqbiol:is>
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+          </rdf:RDF>
+        </annotation>
+      </species>
+      <species metaid="meta_M_kdo2lipid4_c" sboTerm="SBO:0000247" id="M_kdo2lipid4_c" name="KDO(2)-lipid IV(A)" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
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+            <rdf:Description rdf:about="#meta_M_kdo2lipid4_c">
+              <bqbiol:is>
+                <rdf:Bag>
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+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:KDO2-LIPID-IVA"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:28526"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:60365"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/inchi_key/XAOLJGCZESYRFT-VHSKNIDJSA-H"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C06025"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.glycan/G11160"/>
+                  <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMSL02000003"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM824"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd03586"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+      </species>
+      <species metaid="meta_M_kdo8p_c" sboTerm="SBO:0000247" id="M_kdo8p_c" name="3-Deoxy-D-manno-octulosonate 8-phosphate" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
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+            <rdf:Description rdf:about="#meta_M_kdo8p_c">
+              <bqbiol:is>
+                <rdf:Bag>
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+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:KDO-8P"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:18069"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:42115"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:1494"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C04478"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM722774"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/7341"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd02730"/>
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+            </rdf:Description>
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+        </annotation>
+      </species>
+      <species metaid="meta_M_kdolipid4_c" sboTerm="SBO:0000247" id="M_kdolipid4_c" name="KDO-lipid IV(A)" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_M_kdolipid4_c">
+              <bqbiol:is>
+                <rdf:Bag>
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+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:KDO-LIPID-IVA"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:20009"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:27439"/>
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+        </annotation>
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+      <species metaid="meta_M_lac__D_c" sboTerm="SBO:0000247" id="M_lac__D_c" name="D-Lactate" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
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+            <rdf:Description rdf:about="#meta_M_lac__D_c">
+              <bqbiol:is>
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+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:D-LACTATE"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:16004"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:18684"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:42105"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/1997"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/2284"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00221"/>
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+          </rdf:RDF>
+        </annotation>
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+      <species metaid="meta_M_leu__L_c" sboTerm="SBO:0000247" id="M_leu__L_c" name="L-Leucine" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_M_leu__L_c">
+              <bqbiol:is>
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+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:LEU"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:25017"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:15603"/>
+                  <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB00687"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/inchi_key/ROHFNLRQFUQHCH-YFKPBYRVSA-N"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C16439"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/kegg.drug/D00030"/>
+                  <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMFA01100048"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM140"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.compound/29588"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.compound/113580"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.compound/351964"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/21059"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/69"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00107"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd15143"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+      </species>
+      <species metaid="meta_M_lipidA_c" sboTerm="SBO:0000247" id="M_lipidA_c" name="2,3,2&apos;3&apos;-Tetrakis(beta-hydroxymyristoyl)-D-glucosaminyl-1,6-beta-D-glucosamine 1,4&apos;-bisphosphate" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
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+            <rdf:Description rdf:about="#meta_M_lipidA_c">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/lipidA"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:LIPID-IV-A"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:19294"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:11407"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/inchi_key/KVJWZTLXIROHIL-QDORLFPLSA-J"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C04919"/>
+                  <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMSL01040001"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM1754"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd02993"/>
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+              </bqbiol:is>
+            </rdf:Description>
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+        </annotation>
+      </species>
+      <species metaid="meta_M_lipidAds_c" sboTerm="SBO:0000247" id="M_lipidAds_c" name="Lipid A Disaccharide" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_M_lipidAds_c">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/lipidAds"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:BISOHMYR-GLC"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:18380"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:11415"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:11414"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:19293"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:58466"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:862"/>
+                  <rdf:li rdf:resource="https://identifiers.org/inchi_key/HLDJGHAAKRKPAV-QDORLFPLSA-L"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C04932"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM1569"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd03002"/>
+                </rdf:Bag>
+              </bqbiol:is>
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+          </rdf:RDF>
+        </annotation>
+      </species>
+      <species metaid="meta_M_lipidX_c" sboTerm="SBO:0000247" id="M_lipidX_c" name="2,3-Bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
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+        <annotation>
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+      <species metaid="meta_M_malACP_c" sboTerm="SBO:0000247" id="M_malACP_c" name="Malonyl-[acyl-carrier protein]" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
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+            <rdf:Description rdf:about="#meta_M_malACP_c">
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+            <rdf:Description rdf:about="#meta_M_malcoa_c">
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+      <species metaid="meta_M_malcoame_c" sboTerm="SBO:0000247" id="M_malcoame_c" name="Malonyl-CoA methyl ester" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
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+            <rdf:Description rdf:about="#meta_M_malcoame_c">
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+      <species metaid="meta_M_mdhdhf_c" sboTerm="SBO:0000247" id="M_mdhdhf_c" name="(2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
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+            <rdf:Description rdf:about="#meta_M_mdhdhf_c">
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+      <species metaid="meta_M_meoh_c" sboTerm="SBO:0000247" id="M_meoh_c" name="Methanol" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
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+            <rdf:Description rdf:about="#meta_M_meoh_c">
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+      <species metaid="meta_M_met__L_c" sboTerm="SBO:0000247" id="M_met__L_c" name="L-Methionine" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
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+            <rdf:Description rdf:about="#meta_M_met__L_c">
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+                  <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00060"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd30746"/>
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+      <species metaid="meta_M_mlthf_c" sboTerm="SBO:0000247" id="M_mlthf_c" name="5,10-Methylenetetrahydrofolate" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
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+        <annotation>
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+        <annotation>
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+        <annotation>
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+      <species metaid="meta_M_mpt_c" sboTerm="SBO:0000247" id="M_mpt_c" name="Molybdopterin" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
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+      <species metaid="meta_M_mptamp_c" sboTerm="SBO:0000247" id="M_mptamp_c" name="Adenylated molybdopterin" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
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+            <rdf:Description rdf:about="#meta_M_mql8_c">
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+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:REDUCED-MENAQUINONE"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:61684"/>
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+      <species metaid="meta_M_mqn8_c" sboTerm="SBO:0000247" id="M_mqn8_c" name="Menaquinone 8" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
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+      <species metaid="meta_M_mthgxl_c" sboTerm="SBO:0000247" id="M_mthgxl_c" name="Methylglyoxal" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
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+        <annotation>
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+        <annotation>
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+        <annotation>
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+        <annotation>
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+            <rdf:Description rdf:about="#meta_M_palmACP_c">
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+      <species metaid="meta_M_pan4p_c" sboTerm="SBO:0000247" id="M_pan4p_c" name="Pantetheine 4&apos;-phosphate" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
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+        <annotation>
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+            <rdf:Description rdf:about="#meta_M_pant__R_c">
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+        <annotation>
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+        <annotation>
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+        <annotation>
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+            <rdf:Description rdf:about="#meta_M_pheme_c">
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+        <annotation>
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+            <rdf:Description rdf:about="#meta_M_phom_c">
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+      <species metaid="meta_M_phpyr_c" sboTerm="SBO:0000247" id="M_phpyr_c" name="Phenylpyruvate" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
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+            <rdf:Description rdf:about="#meta_M_phpyr_c">
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+        <annotation>
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+        <annotation>
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+        <annotation>
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+        <annotation>
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+            <rdf:Description rdf:about="#meta_M_pphn_c">
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+        <annotation>
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+        <annotation>
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+        <annotation>
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+      <species metaid="meta_M_prbatp_c" sboTerm="SBO:0000247" id="M_prbatp_c" name="1-(5-Phosphoribosyl)-ATP" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
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+            <rdf:Description rdf:about="#meta_M_prbatp_c">
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+        </annotation>
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+      <species metaid="meta_M_prfp_c" sboTerm="SBO:0000247" id="M_prfp_c" name="1-(5-Phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
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+            <rdf:Description rdf:about="#meta_M_prfp_c">
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+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:PHOSPHORIBOSYL-FORMIMINO-AICAR-P"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:11194"/>
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+        <annotation>
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+            <rdf:Description rdf:about="#meta_M_prlp_c">
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+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:39698"/>
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+      <species metaid="meta_M_pro__L_c" sboTerm="SBO:0000247" id="M_pro__L_c" name="L-Proline" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
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+            <rdf:Description rdf:about="#meta_M_pro__L_c">
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+      </species>
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+        <annotation>
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+        <annotation>
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+      <species metaid="meta_M_uppg3_c" sboTerm="SBO:0000247" id="M_uppg3_c" name="Uroporphyrinogen III" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
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+        <annotation>
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+        <annotation>
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+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/82"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00129"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd15140"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+      </species>
+      <species metaid="meta_M_so4_p" sboTerm="SBO:0000247" id="M_so4_p" name="Sulfate" compartment="p" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
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+              <bqbiol:is>
+                <rdf:Bag>
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+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:SULFATE"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:HSO4"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:15135"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:45693"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:29199"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/kegg.drug/D05963"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00048"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+      </species>
+      <species metaid="meta_M_succ_p" sboTerm="SBO:0000247" id="M_succ_p" name="Succinate" compartment="p" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_M_succ_p">
+              <bqbiol:is>
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+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:26803"/>
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+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+      </species>
+      <species metaid="meta_M_zn2_p" sboTerm="SBO:0000247" id="M_zn2_p" name="Zinc" compartment="p" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_M_zn2_p">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/zn2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:ZN+2"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:49972"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:29105"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:27368"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB01303"/>
+                  <rdf:li rdf:resource="https://identifiers.org/inchi_key/PTFCDOFLOPIGGS-UHFFFAOYSA-N"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00038"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/reactome.compound/158417"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00034"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+      </species>
+      <species id="M_glxBIO_c" name="M_glxBIO_c" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_forBIO_c" name="M_forBIO_c" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_Biomass" name="Biomass pseudo-metabolite" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
     </listOfSpecies>
     <listOfParameters>
-      <parameter sboTerm="SBO:0000626" id="cobra_default_lb" value="-INF" constant="true"/>
-      <parameter sboTerm="SBO:0000626" id="cobra_default_ub" value="INF" constant="true"/>
+      <parameter sboTerm="SBO:0000626" id="cobra_default_lb" value="-1000" constant="true"/>
+      <parameter sboTerm="SBO:0000626" id="cobra_default_ub" value="1000" constant="true"/>
       <parameter sboTerm="SBO:0000626" id="cobra_0_bound" value="0" constant="true"/>
       <parameter sboTerm="SBO:0000626" id="minus_inf" value="-INF" constant="true"/>
       <parameter sboTerm="SBO:0000626" id="plus_inf" value="INF" constant="true"/>
@@ -512,7 +13818,11 @@
       <parameter sboTerm="SBO:0000625" id="R_ATPM_lower_bound" value="3.15" units="mmol_per_gDW_per_hr" constant="true"/>
     </listOfParameters>
     <listOfReactions>
-      <reaction metaid="meta_R_EX_Biomass" sboTerm="SBO:0000627" id="R_EX_Biomass" name="EX_Biomass" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf"/>
+      <reaction metaid="meta_R_EX_Biomass" sboTerm="SBO:0000627" id="R_EX_Biomass" name="EX_Biomass" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_Biomass" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
       <reaction id="R_DM_4CRSOL" name="R_DM_4CRSOL" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
         <listOfReactants>
           <speciesReference species="M_4crsol_c" stoichiometry="1" constant="true"/>
@@ -609,149 +13919,1715 @@
           <speciesReference species="M_h_c" stoichiometry="53.95" constant="true"/>
           <speciesReference species="M_pi_c" stoichiometry="53.9457" constant="true"/>
           <speciesReference species="M_ppi_c" stoichiometry="0.7739" constant="true"/>
-        </listOfProducts>
-      </reaction>
-      <reaction id="R_EX_ac_e" name="R_EX_ac_LPAREN_e_RPAREN_" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+          <speciesReference species="M_Biomass" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction metaid="meta_R_EX_ac_e" sboTerm="SBO:0000627" id="R_EX_ac_e" name="Acetate exchange" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
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+            <rdf:Description rdf:about="#meta_R_EX_ac_e">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/EX_ac_e"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN0-1981"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:TRANS-RXN0-567"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95431"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27817"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27814"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27816"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27815"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/12184"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09787"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09866"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn10904"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08063"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_ac_e" stoichiometry="1" constant="true"/>
         </listOfReactants>
       </reaction>
-      <reaction id="R_EX_ca2_e" name="R_EX_ca2_LPAREN_e_RPAREN_" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+      <reaction metaid="meta_R_EX_ca2_e" sboTerm="SBO:0000627" id="R_EX_ca2_e" name="Calcium exchange" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
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+            <rdf:Description rdf:about="#meta_R_EX_ca2_e">
+              <bqbiol:is>
+                <rdf:Bag>
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+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:TRANS-RXN0-497"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:TRANS-RXN-144"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.8"/>
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           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
@@ -761,8 +15637,24 @@
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           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
@@ -773,8 +15665,33 @@
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         <listOfReactants>
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           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
@@ -783,16 +15700,60 @@
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+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0159"/>
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         </listOfReactants>
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+        <fbc:geneProductAssociation>
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+            <fbc:geneProductRef fbc:geneProduct="G_b2708"/>
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+        <annotation>
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+              <bqbiol:is>
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           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
@@ -803,8 +15764,26 @@
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+            <fbc:geneProductRef fbc:geneProduct="G_b1094"/>
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+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_ACP_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
@@ -815,8 +15794,27 @@
           <speciesReference species="M_hdeACP_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_AACPS7" name="R_AACPS7" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:and>
+            <fbc:geneProductRef fbc:geneProduct="G_b2836"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b1094"/>
+          </fbc:and>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_AACPS7" sboTerm="SBO:0000176" id="R_AACPS7" name="Acyl-[acyl-carrier-protein] synthetase  (n-C12:0)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_AACPS7">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/AACPS7"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/6.2.1.l"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95146"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_ACP_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
@@ -827,8 +15825,85 @@
           <speciesReference species="M_ddcaACP_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ACACT1r" name="R_ACACT1r" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:and>
+            <fbc:geneProductRef fbc:geneProduct="G_b2836"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b1094"/>
+          </fbc:and>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ACACT1r" sboTerm="SBO:0000176" id="R_ACACT1r" name="Acetyl-CoA C-acetyltransferase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ACACT1r">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ACACT1r"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:ACETYL-COA-ACETYLTRANSFER-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.1.9"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00238"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95194"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-74181"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-8848215"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-73916"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-74181"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-8848215"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-74181"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-74181"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-73916"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-74181"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-73916"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-74181"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-73916"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-74181"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-73916"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-74181"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-73916"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-73916"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-8848215"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-73916"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-8848215"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-73916"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-74181"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-74181"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-73916"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-74181"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-74181"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-74181"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-8848215"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-73916"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-8848215"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-74181"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-8848215"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-73916"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-74181"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-8848215"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-73916"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-73916"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-8848215"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-74181"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-73916"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-8848215"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-73916"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-73916"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-74181"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-8848215"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-74181"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-8848215"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-73916"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21038"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21037"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21039"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21036"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/531"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00178"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/25.25242739602868"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/3.7028054337695515e-05"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_accoa_c" stoichiometry="2" constant="true"/>
         </listOfReactants>
@@ -836,8 +15911,50 @@
           <speciesReference species="M_aacoa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ACACT2r" name="R_ACACT2r" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b2224"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2342"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b3845"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ACACT2r" sboTerm="SBO:0000176" id="R_ACACT2r" name="Acetyl-CoA C-acyltransferase (butanoyl-CoA) (r)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ACACT2r">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ACACT2r"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN-12565"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.1.9"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.1.16"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01177"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95196"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-77321"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-77321"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-77321"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-77321"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-77321"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-77321"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-77321"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-77321"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-77321"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-77321"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-77321"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/31114"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/31113"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/31111"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/31112"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/1414"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00874"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/30.39901924825881"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.036879691698491146"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_accoa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_btcoa_c" stoichiometry="1" constant="true"/>
@@ -846,8 +15963,27 @@
           <speciesReference species="M_3ohcoa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ACACT3r" name="R_ACACT3r" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b2342"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b3845"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ACACT3r" sboTerm="SBO:0000176" id="R_ACACT3r" name="Acetyl-CoA C-acyltransferase (hexanoyl-CoA) (r)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ACACT3r">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ACACT3r"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.1.9"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95197"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_accoa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_hxcoa_c" stoichiometry="1" constant="true"/>
@@ -856,8 +15992,49 @@
           <speciesReference species="M_3oocoa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ACACT4r" name="R_ACACT4r" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b2342"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b3845"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ACACT4r" sboTerm="SBO:0000176" id="R_ACACT4r" name="Acetyl-CoA C-acyltransferase (octanoyl-CoA) (r)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ACACT4r">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ACACT4r"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN-13617"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.1.9"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.1.16"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R03778"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95198"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-77340"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-77340"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-77340"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-77340"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-77340"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-77340"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-77340"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-77340"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-77340"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-77340"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-77340"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/31087"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/31089"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/31088"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/31090"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/3537"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn02680"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/30.83921494289143"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.004535677246721548"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_accoa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_occoa_c" stoichiometry="1" constant="true"/>
@@ -866,8 +16043,27 @@
           <speciesReference species="M_3odcoa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ACACT5r" name="R_ACACT5r" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b2342"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b3845"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ACACT5r" sboTerm="SBO:0000176" id="R_ACACT5r" name="Acetyl-CoA C-acyltransferase (decanoyl-CoA) (r)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ACACT5r">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ACACT5r"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.1.9"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95199"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_accoa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_dcacoa_c" stoichiometry="1" constant="true"/>
@@ -876,8 +16072,48 @@
           <speciesReference species="M_3oddcoa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ACACT6r" name="R_ACACT6r" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b2342"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b3845"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ACACT6r" sboTerm="SBO:0000176" id="R_ACACT6r" name="Acetyl-CoA C-acyltransferase (dodecanoyl-CoA) (r)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ACACT6r">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ACACT6r"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN-14268"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.1.9"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.1.16"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R03858"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95201"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-77271"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-77271"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-77271"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-77271"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-77271"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-77271"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-77271"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-77271"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-77271"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-77271"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-77271"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/31093"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/31094"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/31092"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/31091"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn06510"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/30.83921494289234"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.004535677246721548"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_accoa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ddcacoa_c" stoichiometry="1" constant="true"/>
@@ -886,8 +16122,51 @@
           <speciesReference species="M_3otdcoa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ACACT7r" name="R_ACACT7r" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b2342"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b3845"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ACACT7r" sboTerm="SBO:0000176" id="R_ACACT7r" name="Acetyl-CoA C-acyltransferase (tetradecanoyl-CoA) (r)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ACACT7r">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ACACT7r"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:2.3.1.155-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN-16560"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.1.9"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.1.16"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.1.155"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R03991"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95203"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-77304"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-77304"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-77304"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-77304"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-77304"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-77304"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-77304"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-77304"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-77304"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-77304"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-77304"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18163"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18164"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18162"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18161"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/3726"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn02804"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/30.839214942890976"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.004535677246721548"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_accoa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_tdcoa_c" stoichiometry="1" constant="true"/>
@@ -896,8 +16175,37 @@
           <speciesReference species="M_3ohdcoa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ACALD" name="R_ACALD" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b2342"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b3845"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ACALD" sboTerm="SBO:0000176" id="R_ACALD" name="Acetaldehyde dehydrogenase (acetylating)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ACALD">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ACALD"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:ACETALD-DEHYDROG-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.2.1.10"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00228"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95210"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23290"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23291"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23289"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23288"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/163"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00171"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-18.133503021812885"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.004080163838370954"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_acald_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
@@ -908,8 +16216,88 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ACCOAC" name="R_ACCOAC" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b0351"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b1241"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ACCOAC" sboTerm="SBO:0000176" id="R_ACCOAC" name="Acetyl-CoA carboxylase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ACCOAC">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ACCOAC"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:ACETYL-COA-CARBOXYLTRANSFER-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/6.4.1.2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00742"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95219"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-200555"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-75851"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-8876889"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-200555"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-75851"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-75851"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-8876889"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-200555"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-8876889"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-75851"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-200555"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-8876889"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-8876889"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-200555"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-200555"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-8876889"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-200555"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-8876889"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-75851"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-75851"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-8876889"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-200555"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-8876889"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-200555"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-8876889"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-8876889"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-75851"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-200555"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-200555"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-8876889"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-200555"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-200555"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-8876889"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-200555"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-8876889"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-75851"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-8876889"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-75851"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-75851"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-8876889"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-200555"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-75851"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-200555"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-75851"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-75851"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-200555"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-8876889"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-75851"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-75851"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-75851"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-75851"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11308"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11311"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11310"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11309"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/542"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00533"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-7.264035975322429"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.08836648400555934"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_accoa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
@@ -921,8 +16309,39 @@
           <speciesReference species="M_malcoa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ACGK" name="R_ACGK" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:and>
+            <fbc:geneProductRef fbc:geneProduct="G_b0185"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2316"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b3255"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b3256"/>
+          </fbc:and>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ACGK" sboTerm="SBO:0000176" id="R_ACGK" name="Acetylglutamate kinase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ACGK">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ACGK"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:ACETYLGLUTKIN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.2.8"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R02649"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95256"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14632"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14631"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14630"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14629"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/2545"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01917"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/25.654204914480943"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.14522744678432564"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_acglu_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
@@ -931,8 +16350,45 @@
           <speciesReference species="M_acg5p_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ACGS" name="R_ACGS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3959"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ACGS" sboTerm="SBO:0000176" id="R_ACGS" name="N-acetylglutamate synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ACGS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ACGS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:N-ACETYLTRANSFER-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.1.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00259"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95259"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-70542"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-70542"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-70542"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-70542"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-70542"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-70542"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-70542"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-70542"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-70542"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-70542"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-70542"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24295"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24292"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24293"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24294"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/764"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00192"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-22.326206469388353"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.04478362967639926"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_accoa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
@@ -942,8 +16398,33 @@
           <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ACHBS" name="R_ACHBS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b2818"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ACHBS" sboTerm="SBO:0000176" id="R_ACHBS" name="2-aceto-2-hydroxybutanoate synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ACHBS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ACHBS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:ACETOOHBUTSYN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.2.1.6"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R08648"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95260"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27657"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27655"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27654"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27656"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/6688"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-20.786157640119086"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.16380561491156742"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_2obut_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
@@ -953,8 +16434,44 @@
           <speciesReference species="M_2ahbut_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ACKr" name="R_ACKr" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b3670"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b3671"/>
+            </fbc:and>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b0077"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b0078"/>
+            </fbc:and>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ACKr" sboTerm="SBO:0000176" id="R_ACKr" name="Acetate kinase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ACKr">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ACKr"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:ACETATEKIN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.2.15"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.2.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00315"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95269"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11354"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11355"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11353"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11352"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/71"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00225"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/14.820831979681884"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-9.620823723037854e-05"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_ac_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
@@ -963,8 +16480,37 @@
           <speciesReference species="M_actp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ACLS" name="R_ACLS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b3115"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2296"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b1849"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ACLS" sboTerm="SBO:0000176" id="R_ACLS" name="Acetolactate synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ACLS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ACLS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:ACETOLACTSYN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.2.1.6"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00226"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95271"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/25252"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/25251"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/25249"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/25250"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/749"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-29.15304203729349"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.1318986497795042"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pyr_c" stoichiometry="2" constant="true"/>
@@ -973,8 +16519,61 @@
           <speciesReference species="M_alac__S_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ACOAD1f" name="R_ACOAD1f" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b3670"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b3671"/>
+            </fbc:and>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b0077"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b0078"/>
+            </fbc:and>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ACOAD1f" sboTerm="SBO:0000176" id="R_ACOAD1f" name="Acyl-CoA dehydrogenase (butanoyl-CoA)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ACOAD1f">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ACOAD1f"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.99.3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.8.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.99.-"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.3.6"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.8.7"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01175"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95302"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-77319"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-77319"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-77319"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-77319"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-77319"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-77319"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-77319"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-77319"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-77319"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-77319"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-77319"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24006"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/30733"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24007"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/30734"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24005"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24004"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/30731"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/30732"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/1412"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00872"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/31.78118690733936"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.14999921991349652"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_btcoa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_fad_c" stoichiometry="1" constant="true"/>
@@ -983,8 +16582,24 @@
           <speciesReference species="M_b2coa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_fadh2_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ACOAD2f" name="R_ACOAD2f" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0221"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ACOAD2f" sboTerm="SBO:0000176" id="R_ACOAD2f" name="Acyl-CoA dehydrogenase (hexanoyl-CoA)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ACOAD2f">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ACOAD2f"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.99.3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95303"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_fad_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_hxcoa_c" stoichiometry="1" constant="true"/>
@@ -993,8 +16608,52 @@
           <speciesReference species="M_fadh2_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_hx2coa_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ACOAD3f" name="R_ACOAD3f" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0221"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ACOAD3f" sboTerm="SBO:0000176" id="R_ACOAD3f" name="Acyl-CoA dehydrogenase (octanoyl-CoA)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ACOAD3f">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ACOAD3f"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.99.3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.99.-"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.3.6"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.8.8"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.8.7"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R03777"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95304"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-77338"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-77338"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-77338"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-77338"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-77338"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-77338"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-77338"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-77338"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-77338"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-77338"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-77338"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/48182"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/30945"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/30944"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/48183"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/48181"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/48180"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/30943"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/30946"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/3536"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn02679"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/37.582933017525875"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.007803144271261164"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_fad_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_occoa_c" stoichiometry="1" constant="true"/>
@@ -1003,8 +16662,24 @@
           <speciesReference species="M_fadh2_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_oc2coa_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ACOAD4f" name="R_ACOAD4f" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0221"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ACOAD4f" sboTerm="SBO:0000176" id="R_ACOAD4f" name="Acyl-CoA dehydrogenase (decanoyl-CoA)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ACOAD4f">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ACOAD4f"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.99.3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95298"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_dcacoa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_fad_c" stoichiometry="1" constant="true"/>
@@ -1013,8 +16688,51 @@
           <speciesReference species="M_dc2coa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_fadh2_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ACOAD5f" name="R_ACOAD5f" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0221"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ACOAD5f" sboTerm="SBO:0000176" id="R_ACOAD5f" name="Acyl-CoA dehydrogenase (dodecanoyl-CoA)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ACOAD5f">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ACOAD5f"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.99.3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.99.-"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.3.6"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.8.8"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.8.7"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R03857"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95299"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-77263"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-77263"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-77263"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-77263"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-77263"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-77263"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-77263"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-77263"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-77263"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-77263"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/47298"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/47296"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/31040"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/47297"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/31042"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/31039"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/47299"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/31041"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/3607"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn02720"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/37.5829330175261"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.007803144271261608"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_ddcacoa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_fad_c" stoichiometry="1" constant="true"/>
@@ -1023,8 +16741,52 @@
           <speciesReference species="M_dd2coa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_fadh2_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ACOAD6f" name="R_ACOAD6f" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0221"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ACOAD6f" sboTerm="SBO:0000176" id="R_ACOAD6f" name="Acyl-CoA dehydrogenase (tetradecanoyl-CoA)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ACOAD6f">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ACOAD6f"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.99.3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.8.9"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.99.-"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.3.6"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.8.8"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.8.7"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R03990"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95300"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-77274"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-77274"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-77274"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-77274"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-77274"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-77274"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-77274"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-77274"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-77274"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-77274"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28361"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28358"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28359"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/47319"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/47318"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/47316"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/47317"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28360"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/3725"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn02803"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/37.5829330175261"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.007803144271261164"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_fad_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_tdcoa_c" stoichiometry="1" constant="true"/>
@@ -1033,8 +16795,42 @@
           <speciesReference species="M_fadh2_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_td2coa_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ACOAD7f" name="R_ACOAD7f" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0221"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ACOAD7f" sboTerm="SBO:0000176" id="R_ACOAD7f" name="Acyl-CoA dehydrogenase (hexadecanoyl-CoA)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ACOAD7f">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ACOAD7f"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.99.3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.8.9"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.99.-"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.3.6"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.8.8"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.8.7"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01279"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95301"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/43449"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/30748"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/43448"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/30747"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/43451"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/30750"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/30749"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/43450"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/1495"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00946"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/41.18717406556107"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0104865435254482"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_fad_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pmtcoa_c" stoichiometry="1" constant="true"/>
@@ -1043,8 +16839,35 @@
           <speciesReference species="M_fadh2_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_hdd2coa_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ACODA" name="R_ACODA" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0221"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ACODA" sboTerm="SBO:0000176" id="R_ACODA" name="Acetylornithine deacetylase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ACODA">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ACODA"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:ACETYLORNDEACET-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.5.1.16"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.5.1.14"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00669"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95377"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15941"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15942"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15944"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15943"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/1049"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00469"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-6.858882053395234"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.04416767893135809"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_acorn_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
@@ -1053,8 +16876,32 @@
           <speciesReference species="M_ac_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_orn_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ACONTa" name="R_ACONTa" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3957"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ACONTa" sboTerm="SBO:0000176" id="R_ACONTa" name="Aconitase (half-reaction A, Citrate hydro-lyase)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ACONTa">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ACONTa"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:ACONITATEDEHYDR-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.2.1.3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01325"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95386"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10230"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10229"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10231"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10228"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/268"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00974"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_cit_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
@@ -1062,8 +16909,33 @@
           <speciesReference species="M_acon__C_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ACONTb" name="R_ACONTb" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b0118"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b1276"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ACONTb" sboTerm="SBO:0000176" id="R_ACONTb" name="Aconitase (half-reaction B, Isocitrate hydro-lyase)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ACONTb">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ACONTb"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.2.1.3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01900"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95387"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22145"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22144"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22146"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22147"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01388"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_acon__C_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
@@ -1071,8 +16943,37 @@
         <listOfProducts>
           <speciesReference species="M_icit_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ACOTA" name="R_ACOTA" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b0118"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b1276"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ACOTA" sboTerm="SBO:0000176" id="R_ACOTA" name="Acetylornithine transaminase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ACOTA">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ACOTA"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:ACETYLORNTRANSAM-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.6.1.11"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R02283"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95388"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18051"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18050"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18052"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18049"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/2248"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01637"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-2.8923225431487936"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.048565583285073016"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_acorn_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_akg_c" stoichiometry="1" constant="true"/>
@@ -1081,8 +16982,26 @@
           <speciesReference species="M_acg5sa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ACPPAT160" name="R_ACPPAT160" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b1748"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b3359"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ACPPAT160" sboTerm="SBO:0000176" id="R_ACPPAT160" name="Acyl-(acyl carrier protein):phosphate acyltransferase (C16:0)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ACPPAT160">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ACPPAT160"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95398"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_palmACP_c" stoichiometry="1" constant="true"/>
@@ -1092,8 +17011,26 @@
           <speciesReference species="M_ACP_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_hdcap_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ACPPAT161" name="R_ACPPAT161" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:and>
+            <fbc:geneProductRef fbc:geneProduct="G_b1094"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b1090"/>
+          </fbc:and>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ACPPAT161" sboTerm="SBO:0000176" id="R_ACPPAT161" name="Acyl-(acyl carrier protein):phosphate acyltransferase (C16:1)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ACPPAT161">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ACPPAT161"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95399"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_hdeACP_c" stoichiometry="1" constant="true"/>
@@ -1103,8 +17040,31 @@
           <speciesReference species="M_ACP_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_hdceap_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ACt2rpp" name="R_ACt2rpp" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:and>
+            <fbc:geneProductRef fbc:geneProduct="G_b1094"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b1090"/>
+          </fbc:and>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ACt2rpp" sboTerm="SBO:0000185" id="R_ACt2rpp" name="Acetate reversible transport via proton symport (periplasm)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ACt2rpp">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ACt2rpp"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:TRANS-RXN0-571"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95429"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08061"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn05488"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-2.8494489889199226"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/1.0536712127723509e-08"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_ac_p" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_p" stoichiometry="1" constant="true"/>
@@ -1114,15 +17074,70 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction id="R_ACtex" name="R_ACtex" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+      <reaction metaid="meta_R_ACtex" sboTerm="SBO:0000185" id="R_ACtex" name="Acetate transport via diffusion (extracellular to periplasm)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ACtex">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ACtex"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN0-1981"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:TRANS-RXN0-567"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95431"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27817"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27814"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27816"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27815"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/12184"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09787"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09866"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn10904"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08063"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/14.47275"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/1.0536712127723509e-08"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_ac_e" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_ac_p" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ADCL" name="R_ADCL" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b0241"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0929"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b1377"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2215"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ADCL" sboTerm="SBO:0000176" id="R_ADCL" name="4-aminobenzoate synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ADCL">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ADCL"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:ADCLY-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.1.3.38"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R05553"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95436"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16201"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16203"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16204"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16202"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn03841"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-88.62995054120454"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/2.0988658406169867"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_4adcho_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
@@ -1131,8 +17146,34 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ADCS" name="R_ADCS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b1096"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ADCS" sboTerm="SBO:0000176" id="R_ADCS" name="4-amino-4-deoxychorismate synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ADCS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ADCS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:PABASYN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.6.1.85"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01716"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95440"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11672"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11675"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11673"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11674"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/1828"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01257"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-17.88308576730992"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.00029275513103490776"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_chor_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_gln__L_c" stoichiometry="1" constant="true"/>
@@ -1141,8 +17182,73 @@
           <speciesReference species="M_4adcho_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ADK1" name="R_ADK1" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:and>
+            <fbc:geneProductRef fbc:geneProduct="G_b3360"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b1812"/>
+          </fbc:and>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ADK1" sboTerm="SBO:0000176" id="R_ADK1" name="Adenylate kinase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ADK1">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ADK1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:ADENYL-KIN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.4.3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00127"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95450"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-110145"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-110144"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-110144"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-110145"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-110145"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-110144"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-110145"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-110144"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-110145"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-110145"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-110145"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-110144"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-110144"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-110145"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-110144"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-110144"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-110144"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-110145"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-110144"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-110145"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-110144"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-110144"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-110145"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-110144"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-110144"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-110144"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-110145"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-110144"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-110144"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-110145"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-110145"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-110145"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-110145"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-110145"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-110144"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-110145"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12975"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12973"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12976"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12974"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/82"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00097"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-0.1515600836125941"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/5.8192201936177294e-05"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_amp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
@@ -1150,8 +17256,35 @@
         <listOfProducts>
           <speciesReference species="M_adp_c" stoichiometry="2" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ADNK1" name="R_ADNK1" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0474"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ADNK1" sboTerm="SBO:0000176" id="R_ADNK1" name="Adenosine kinase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ADNK1">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ADNK1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:ADENOSINE-KINASE-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.1.74"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.1.20"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00185"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95456"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/20827"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/20824"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/20826"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/20825"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/252"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00134"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-11.516001746833012"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.002599212568185092"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_adn_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
@@ -1161,8 +17294,50 @@
           <speciesReference species="M_amp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ADSK" name="R_ADSK" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0474"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ADSK" sboTerm="SBO:0000176" id="R_ADSK" name="Adenylyl-sulfate kinase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ADSK">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ADSK"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:ADENYLYLSULFKIN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.1.25"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00509"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95159"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-174389"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-174389"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-174389"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-174389"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-174389"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-174389"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-174389"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-174389"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-174389"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-174389"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-174389"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-174389"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-174389"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-174389"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-174389"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-174389"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24155"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24152"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24154"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24153"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/237"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00361"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-14.187209509690149"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.08944077485179527"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_aps_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
@@ -1172,8 +17347,52 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_paps_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ADSL1r" name="R_ADSL1r" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b2750"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ADSL1r" sboTerm="SBO:0000176" id="R_ADSL1r" name="Adenylsuccinate lyase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ADSL1r">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ADSL1r"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:AMPSYN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.3.2.2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01083"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95493"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-421197"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-73828"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-73828"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-73828"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-73828"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-73828"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-73828"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-73828"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-73828"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-73828"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-73828"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-73828"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-73828"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-73828"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-73828"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-73828"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-73828"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-73828"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16854"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16853"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16856"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16855"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/306"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00800"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/18.510364650335845"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0003873894847463326"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_dcamp_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
@@ -1181,8 +17400,51 @@
           <speciesReference species="M_amp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_fum_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ADSL2r" name="R_ADSL2r" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b1131"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ADSL2r" sboTerm="SBO:0000176" id="R_ADSL2r" name="Adenylosuccinate lyase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ADSL2r">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ADSL2r"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:AICARSYN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.3.2.2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R04559"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR108966"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-73800"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-73800"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-73800"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-73800"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-73800"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-73800"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-73800"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-73800"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-73800"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-73800"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-419255"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-73800"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-73800"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-73800"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-73800"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-73800"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-73800"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-73800"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23920"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23923"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23922"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23921"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/121"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/25.90324403479164"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/2.1293730667615307e-15"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_25aics_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
@@ -1190,8 +17452,54 @@
           <speciesReference species="M_aicar_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_fum_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ADSS" name="R_ADSS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b1131"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ADSS" sboTerm="SBO:0000176" id="R_ADSS" name="Adenylosuccinate synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ADSS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ADSS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:ADENYLOSUCCINATE-SYNTHASE-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/6.3.4.4"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01135"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95495"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-421201"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-111524"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-111524"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-111524"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-111524"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-111519"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-111524"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-111524"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-111524"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-111524"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-111524"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-111524"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-111524"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-111524"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-111524"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-111524"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-111524"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-111524"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-111524"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-111524"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15755"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15756"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15753"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15754"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/228"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00838"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/2.0823734456587886"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0015495579389923544"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_asp__L_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_gtp_c" stoichiometry="1" constant="true"/>
@@ -1203,8 +17511,24 @@
           <speciesReference species="M_h_c" stoichiometry="2" constant="true"/>
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_AGPAT160" name="R_AGPAT160" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b4177"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_AGPAT160" sboTerm="SBO:0000176" id="R_AGPAT160" name="1-hexadecanoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C16:0)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_AGPAT160">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/AGPAT160"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.1.51"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95561"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_1hdecg3p_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_palmACP_c" stoichiometry="1" constant="true"/>
@@ -1213,8 +17537,26 @@
           <speciesReference species="M_ACP_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pa160_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_AGPAT161" name="R_AGPAT161" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3018"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_AGPAT161" sboTerm="SBO:0000176" id="R_AGPAT161" name="1-hexadec-7-enoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C16:1)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_AGPAT161">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/AGPAT161"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.1.51"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95564"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/0.0"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_1hdec9eg3p_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_hdeACP_c" stoichiometry="1" constant="true"/>
@@ -1223,8 +17565,33 @@
           <speciesReference species="M_ACP_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pa161_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_AGPR" name="R_AGPR" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3018"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_AGPR" sboTerm="SBO:0000176" id="R_AGPR" name="N-acetyl-g-glutamyl-phosphate reductase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_AGPR">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/AGPR"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:N-ACETYLGLUTPREDUCT-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.2.1.38"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R03443"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95530"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21590"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21591"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21588"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21589"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn02465"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/8.077079697247427"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.010802149123603888"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_acg5sa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
@@ -1235,8 +17602,33 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_AHCYSNS" name="R_AHCYSNS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3958"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_AHCYSNS" sboTerm="SBO:0000176" id="R_AHCYSNS" name="S-adenosylhomocysteine nucleosidase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_AHCYSNS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/AHCYSNS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:ADENOSYLHOMOCYSTEINE-NUCLEOSIDASE-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.2.2.9"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00194"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95625"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17806"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17808"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17805"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17807"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00143"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-17.71021686212714"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.010038958185083227"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_ahcys_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
@@ -1245,8 +17637,49 @@
           <speciesReference species="M_ade_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_rhcys_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_AICART" name="R_AICART" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0159"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_AICART" sboTerm="SBO:0000176" id="R_AICART" name="Phosphoribosylaminoimidazolecarboxamide formyltransferase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_AICART">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/AICART"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.1.2.3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R04560"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95639"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-73798"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-73798"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-73798"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-419254"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-73798"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-73798"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-73798"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-73798"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-73798"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-73798"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-73798"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-73798"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-73798"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-73798"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-73798"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-73798"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-73798"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22192"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22193"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22195"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22194"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/122"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/10.36950232106119"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.5151245121898924"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_10fthf_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_aicar_c" stoichiometry="1" constant="true"/>
@@ -1255,8 +17688,30 @@
           <speciesReference species="M_fprica_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_thf_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_AIRC2" name="R_AIRC2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b4006"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_AIRC2" sboTerm="SBO:0000176" id="R_AIRC2" name="Phosphoribosylaminoimidazole carboxylase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_AIRC2">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/AIRC2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/6.3.4.18"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95644"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/19318"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/19320"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/19319"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/19317"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-51.85162269115477"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.6243740367974114"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_air_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
@@ -1268,16 +17723,89 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_AIRC3" name="R_AIRC3" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0522"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_AIRC3" sboTerm="SBO:0000176" id="R_AIRC3" name="Phosphoribosylaminoimidazole carboxylase (mutase rxn)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_AIRC3">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/AIRC3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN0-743"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/5.4.99.18"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R07405"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95645"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13194"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13196"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13195"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13193"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn05115"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-29.93118826921676"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.6587969077462774"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_5aizc_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_5caiz_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_AKGDH" name="R_AKGDH" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0523"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_AKGDH" sboTerm="SBO:0000176" id="R_AKGDH" name="2-Oxogluterate dehydrogenase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_AKGDH">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/AKGDH"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:2OXOGLUTARATEDEH-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.2.1.52"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.1.61"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.8.1.4"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.2.4.2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R08549"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95655"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-71401"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-71401"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-71401"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-71401"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-71401"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-71401"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-71401"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-71401"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-71401"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-71401"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-71401"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-373042"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-71401"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-71401"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-71401"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-71401"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-71401"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-71401"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-71401"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27789"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27788"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27786"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27787"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/8163"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08094"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-29.56226247855784"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.009356940213820164"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_akg_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
@@ -1288,8 +17816,39 @@
           <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_succoa_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ALAALAr" name="R_ALAALAr" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:and>
+            <fbc:geneProductRef fbc:geneProduct="G_b0116"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0726"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0727"/>
+          </fbc:and>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ALAALAr" sboTerm="SBO:0000176" id="R_ALAALAr" name="D-alanine-D-alanine ligase (reversible)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ALAALAr">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ALAALAr"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:DALADALALIG-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/6.3.2.4"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01150"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95678"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11226"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11224"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11225"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11227"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/1391"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn13802"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00851"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-25.127856287536986"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.13057913651681305"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_ala__D_c" stoichiometry="2" constant="true"/>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
@@ -1300,16 +17859,92 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ALAR" name="R_ALAR" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b0381"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0092"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ALAR" sboTerm="SBO:0000176" id="R_ALAR" name="Alanine racemase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ALAR">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ALAR"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:ALARACECAT-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/5.1.1.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00401"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95693"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/20252"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/20251"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/20249"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/20250"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/862"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00283"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-0.04088349794153601"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-2.4521716039159827e-06"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_ala__L_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_ala__D_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ALCD2x" name="R_ALCD2x" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b1190"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b4053"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ALCD2x" sboTerm="SBO:0000176" id="R_ALCD2x" name="Alcohol dehydrogenase (ethanol)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ALCD2x">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ALCD2x"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:ALCOHOL-DEHYDROG-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.71"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00754"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95725"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-71707"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-71707"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-71707"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-71707"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-71707"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-71707"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-71707"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-71707"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-71707"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-71707"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-71707"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-71707"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-71707"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-71707"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-71707"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-71707"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-71707"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/25292"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/25290"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/25291"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/25293"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/597"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00543"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/21.270207150224223"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.000137354495617803"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_etoh_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
@@ -1319,8 +17954,38 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_AMAOTr" name="R_AMAOTr" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b1478"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b1241"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0356"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_AMAOTr" sboTerm="SBO:0000176" id="R_AMAOTr" name="Adenosylmethionine-8-amino-7-oxononanoate transaminase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_AMAOTr">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/AMAOTr"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:DAPASYN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.6.1.62"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R03231"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95806"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16863"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16861"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16862"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16864"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/3057"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn02312"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-0.5827135628373412"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/1.1102230246251565e-15"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_8aonn_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_amet_c" stoichiometry="1" constant="true"/>
@@ -1329,8 +17994,23 @@
           <speciesReference species="M_amob_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_dann_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_AMPMS2" name="R_AMPMS2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0774"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_AMPMS2" sboTerm="SBO:0000176" id="R_AMPMS2" name="4-amino-2-methyl-5-phosphomethylpyrimidine synthetase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_AMPMS2">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/AMPMS2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR142626"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_air_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
@@ -1342,8 +18022,33 @@
           <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_forBIO_c" stoichiometry="2" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ANPRT" name="R_ANPRT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3994"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ANPRT" sboTerm="SBO:0000176" id="R_ANPRT" name="Anthranilate phosphoribosyltransferase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ANPRT">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ANPRT"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:PRTRANS-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.4.2.18"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01073"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95842"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11771"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11770"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11768"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11769"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00791"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-61.549992911318895"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.4675611001926956"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_anth_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_prpp_c" stoichiometry="1" constant="true"/>
@@ -1352,8 +18057,34 @@
           <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pran_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ANS" name="R_ANS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b1263"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ANS" sboTerm="SBO:0000176" id="R_ANS" name="Anthranilate synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ANS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ANS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:ANTHRANSYN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.1.3.27"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00986"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95843"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21734"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21733"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21735"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21732"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/1280"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00727"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-106.51631974272838"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/2.099158595748022"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_chor_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_gln__L_c" stoichiometry="1" constant="true"/>
@@ -1364,8 +18095,29 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_AOXSr2" name="R_AOXSr2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:and>
+            <fbc:geneProductRef fbc:geneProduct="G_b1263"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b1264"/>
+          </fbc:and>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_AOXSr2" sboTerm="SBO:0000176" id="R_AOXSr2" name="8-amino-7-oxononanoate synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_AOXSr2">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/AOXSr2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN-11484"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.1.47"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R10124"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95855"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_ala__L_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pimACP_c" stoichiometry="1" constant="true"/>
@@ -1375,8 +18127,23 @@
           <speciesReference species="M_ACP_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_APG3PAT160" name="R_APG3PAT160" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0776"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_APG3PAT160" sboTerm="SBO:0000176" id="R_APG3PAT160" name="Acyl-phosphate:glycerol-3-phosphate acyltransferase (C16:0)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_APG3PAT160">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/APG3PAT160"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95872"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_glyc3p_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_hdcap_c" stoichiometry="1" constant="true"/>
@@ -1386,8 +18153,23 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_APG3PAT161" name="R_APG3PAT161" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3059"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_APG3PAT161" sboTerm="SBO:0000176" id="R_APG3PAT161" name="Acyl-phosphate:glycerol-3-phosphate acyltransferase (C16:1)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_APG3PAT161">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/APG3PAT161"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95873"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_glyc3p_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_hdceap_c" stoichiometry="1" constant="true"/>
@@ -1397,8 +18179,33 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_APRAUR" name="R_APRAUR" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3059"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_APRAUR" sboTerm="SBO:0000176" id="R_APRAUR" name="5-amino-6-(5-phosphoribosylamino)uracil reductase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_APRAUR">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/APRAUR"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RIBOFLAVINSYNREDUC-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.193"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R03458"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95898"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17848"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17846"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17847"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17845"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn02474"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-28.073075351992884"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.11435993780311482"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_5apru_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
@@ -1408,8 +18215,46 @@
           <speciesReference species="M_5aprbu_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ARGSL" name="R_ARGSL" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0414"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ARGSL" sboTerm="SBO:0000176" id="R_ARGSL" name="Argininosuccinate lyase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ARGSL">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ARGSL"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:ARGSUCCINLYA-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.3.2.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01086"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR138059"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-70573"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-70573"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-70573"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-70573"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-70573"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-70573"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-70573"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-70573"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-70573"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-70573"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-70573"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-70573"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24021"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24020"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24022"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24023"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/573"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00802"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-9.59311639431158"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.23742214948923143"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_argsuc_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
@@ -1417,8 +18262,43 @@
           <speciesReference species="M_arg__L_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_fum_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ARGSS" name="R_ARGSS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3960"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ARGSS" sboTerm="SBO:0000176" id="R_ARGSS" name="Argininosuccinate synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ARGSS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ARGSS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:ARGSUCCINSYN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/6.3.4.5"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01954"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR138060"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-70577"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-70577"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-70577"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-70577"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-70577"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-70577"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-70577"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-70577"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-70577"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10933"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10935"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10934"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10932"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/572"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01434"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/21.7644135120715"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.23742214948923712"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_asp__L_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
@@ -1430,8 +18310,34 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ASAD" name="R_ASAD" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3172"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ASAD" sboTerm="SBO:0000176" id="R_ASAD" name="Aspartate-semialdehyde dehydrogenase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ASAD">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ASAD"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:ASPARTATE-SEMIALDEHYDE-DEHYDROGENASE-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.2.1.11"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R02291"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR96039"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24285"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24284"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24286"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24287"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/2255"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01643"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-20.289786311964917"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-5.10702591327572e-15"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_aspsa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
@@ -1442,8 +18348,34 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ASNS2" name="R_ASNS2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3433"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ASNS2" sboTerm="SBO:0000176" id="R_ASNS2" name="Asparagine synthetase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ASNS2">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ASNS2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:ASNSYNA-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/6.3.1.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/6.3.5.4"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00483"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR96060"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11372"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11375"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11374"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11373"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00340"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-20.74804999547898"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0024849792509852534"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_asp__L_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
@@ -1455,8 +18387,32 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ASP1DC" name="R_ASP1DC" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3744"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ASP1DC" sboTerm="SBO:0000176" id="R_ASP1DC" name="Aspartate 1-decarboxylase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ASP1DC">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ASP1DC"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:ASPDECARBOX-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.1.1.15"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.1.1.11"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00489"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR96077"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/19500"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/19499"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/19498"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/19497"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00346"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_asp__L_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
@@ -1465,8 +18421,53 @@
           <speciesReference species="M_ala__B_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ASPCT" name="R_ASPCT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0131"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ASPCT" sboTerm="SBO:0000176" id="R_ASPCT" name="Aspartate carbamoyltransferase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ASPCT">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ASPCT"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:ASPCARBTRANS-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.1.3.2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01397"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR96080"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-73573"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-73573"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-73573"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-73573"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-73573"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-73573"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-73573"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-73573"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-73573"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-73573"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-73573"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-419451"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-73573"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-73573"/>
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           <speciesReference species="M_cbp_c" stoichiometry="1" constant="true"/>
@@ -1476,8 +18477,40 @@
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+        <fbc:geneProductAssociation>
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+            <fbc:geneProductRef fbc:geneProduct="G_b4245"/>
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@@ -1486,8 +18519,36 @@
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+            <fbc:geneProductRef fbc:geneProduct="G_b4024"/>
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@@ -1497,8 +18558,105 @@
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-      <reaction id="R_ASPTA" name="R_ASPTA" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
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         <listOfReactants>
           <speciesReference species="M_akg_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_asp__L_c" stoichiometry="1" constant="true"/>
@@ -1507,8 +18665,104 @@
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+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.11"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.28"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.30"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.4.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.4.11"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.47"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.4.6"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.36"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.21"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.12"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.18"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.26"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.27"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.7"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.4.9"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.4.7"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.46"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.41"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.49"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00086"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR96131"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13066"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13065"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13068"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13067"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/75"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn11300"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09694"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00062"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-26.76609174810875"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.00047681174402202167"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
@@ -1519,7 +18773,29 @@
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction id="R_ATPPRT" name="R_ATPPRT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+      <reaction metaid="meta_R_ATPPRT" sboTerm="SBO:0000176" id="R_ATPPRT" name="ATP phosphoribosyltransferase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ATPPRT">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ATPPRT"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:ATPPHOSPHORIBOSYLTRANS-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.4.2.17"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01071"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR96132"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18476"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18475"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18473"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18474"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00789"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/4127.475376155645"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.006689011837626729"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_prpp_c" stoichiometry="1" constant="true"/>
@@ -1528,8 +18804,29 @@
           <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_prbatp_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ATPS4rpp" name="R_ATPS4rpp" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b2019"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ATPS4rpp" sboTerm="SBO:0000185" id="R_ATPS4rpp" name="ATP synthase (four protons for one ATP) (periplasm)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ATPS4rpp">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ATPS4rpp"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:ATPSYN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.14"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR96136"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08173"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn10042"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-40.08227377736068"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.30427785529910184"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
@@ -1540,8 +18837,45 @@
           <speciesReference species="M_h_c" stoichiometry="3" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_BMOCOS" name="R_BMOCOS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b3736"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b3737"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b3738"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b3731"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b3732"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b3733"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b3734"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b3735"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b3739"/>
+            </fbc:and>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b3736"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b3737"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b3738"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b3731"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b3732"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b3733"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b3734"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b3735"/>
+            </fbc:and>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_BMOCOS" sboTerm="SBO:0000176" id="R_BMOCOS" name="Bis-molybdenum cofactor synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_BMOCOS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/BMOCOS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR138144"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_moco_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_mptamp_c" stoichiometry="1" constant="true"/>
@@ -1551,8 +18885,23 @@
           <speciesReference species="M_bmoco_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_cu2_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_BMOGDS1" name="R_BMOGDS1" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0827"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_BMOGDS1" sboTerm="SBO:0000176" id="R_BMOGDS1" name="Bis-molybdopterin guanine dinucleotide synthase (single GDP)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_BMOGDS1">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/BMOGDS1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR96315"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_bmoco_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_gtp_c" stoichiometry="1" constant="true"/>
@@ -1562,8 +18911,29 @@
           <speciesReference species="M_bmoco1gdp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_BMOGDS2" name="R_BMOGDS2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b3857"/>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b3857"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b3856"/>
+            </fbc:and>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_BMOGDS2" sboTerm="SBO:0000176" id="R_BMOGDS2" name="Bis-molybdopterin guanine dinucleotide synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_BMOGDS2">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/BMOGDS2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR96316"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_bmoco1gdp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_gtp_c" stoichiometry="1" constant="true"/>
@@ -1573,8 +18943,55 @@
           <speciesReference species="M_bmocogdp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_BPNT" name="R_BPNT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b3857"/>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b3857"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b3856"/>
+            </fbc:and>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_BPNT" sboTerm="SBO:0000176" id="R_BPNT" name="3&apos;,5&apos;-bisphosphate nucleotidase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_BPNT">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/BPNT"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:325-BISPHOSPHATE-NUCLEOTIDASE-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.1.3.7"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.1.3.97"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00188"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR96321"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-176606"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-176606"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-176606"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-176606"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-176606"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-176606"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-176606"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-176606"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-176606"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-176606"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-176606"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-176606"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-176606"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10041"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10040"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10043"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10042"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/736"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00137"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn11357"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-6.3915181491697695"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.07950698960769671"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pap_c" stoichiometry="1" constant="true"/>
@@ -1583,8 +19000,23 @@
           <speciesReference species="M_amp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_BTS5" name="R_BTS5" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b4214"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_BTS5" sboTerm="SBO:0000176" id="R_BTS5" name="Biotin synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_BTS5">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/BTS5"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR96344"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_2fe2s_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_amet_c" stoichiometry="1" constant="true"/>
@@ -1597,16 +19029,224 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_met__L_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_CA2tex" name="R_CA2tex" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0775"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_CA2tex" sboTerm="SBO:0000185" id="R_CA2tex" name="Calcium (Ca+2) transport via diffusion (extracellular to periplasm)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_CA2tex">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/CA2tex"/>
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+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b0241"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0929"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b1377"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2215"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_COBALT2tpp" sboTerm="SBO:0000185" id="R_COBALT2tpp" name="Cobalt transport in via permease (no H+)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_COBALT2tpp">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/COBALT2tpp"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:TRANS-RXN-141A"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR96821"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28579"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28580"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28581"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28578"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/12148"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08241"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08242"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn10474"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-28.379930135339706"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_cobalt2_p" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_cobalt2_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_CPMPS" name="R_CPMPS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b3040"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b3816"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_CPMPS" sboTerm="SBO:0000176" id="R_CPMPS" name="Cyclic pyranopterin monophosphate synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_CPMPS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/CPMPS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.1.99.18"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR142714"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_gtp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
@@ -1724,8 +19907,35 @@
           <speciesReference species="M_cpmp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_CPPPGO2" name="R_CPPPGO2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:and>
+            <fbc:geneProductRef fbc:geneProduct="G_b0781"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0783"/>
+          </fbc:and>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_CPPPGO2" sboTerm="SBO:0000176" id="R_CPPPGO2" name="Oxygen Independent coproporphyrinogen-III oxidase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_CPPPGO2">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/CPPPGO2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:HEMN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.98.3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.99.22"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R06895"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR96881"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15425"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15427"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15428"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15426"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn04704"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_amet_c" stoichiometry="2" constant="true"/>
           <speciesReference species="M_cpppg3_c" stoichiometry="1" constant="true"/>
@@ -1736,8 +19946,55 @@
           <speciesReference species="M_met__L_c" stoichiometry="2" constant="true"/>
           <speciesReference species="M_pppg9_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_CS" name="R_CS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3867"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_CS" sboTerm="SBO:0000176" id="R_CS" name="Citrate synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_CS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/CS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:CITSYN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN-14905"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.3.16"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.3.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.3.3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00351"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR96920"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-373006"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-70975"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-70975"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-70975"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-70975"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-70975"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-70975"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-70975"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-70975"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-70975"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-70975"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-70975"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-70975"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-70975"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-70975"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-70975"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-70975"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-70975"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16847"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16846"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16845"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16848"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/267"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00256"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-36.9346638173065"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0005755481893411907"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_accoa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
@@ -1748,16 +20005,92 @@
           <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_CTECOAI7" name="R_CTECOAI7" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0720"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_CTECOAI7" sboTerm="SBO:0000176" id="R_CTECOAI7" name="3-cis-2-trans-enoyl-CoA isomerase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_CTECOAI7">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/CTECOAI7"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/5.3.3.8"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR96941"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_hdcoa_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_hdd2coa_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_CTPS2" name="R_CTPS2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3846"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_CTPS2" sboTerm="SBO:0000176" id="R_CTPS2" name="CTP synthase (glutamine)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_CTPS2">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/CTPS2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:CTPSYN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/6.3.4.2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00573"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR96945"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-504054"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-73647"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-73647"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-73647"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-504054"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-504054"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-73647"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-73647"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-504054"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-504054"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-73647"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-504054"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-504054"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-504054"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-73647"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-504054"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-73647"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-504054"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-73647"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-73647"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-73647"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-73647"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-73647"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-504054"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-73647"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-504054"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-504054"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-73647"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-504054"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-73647"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-504054"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-73647"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-504054"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/26427"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/26429"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/26426"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/26428"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/459"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00412"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn11276"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-20.268574149866026"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.005100969907983489"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_gln__L_c" stoichiometry="1" constant="true"/>
@@ -1771,24 +20104,130 @@
           <speciesReference species="M_h_c" stoichiometry="2" constant="true"/>
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_CU2tex" name="R_CU2tex" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b2780"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_CU2tex" sboTerm="SBO:0000185" id="R_CU2tex" name="Copper (Cu+2) transport via diffusion (extracellular to periplasm)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_CU2tex">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/CU2tex"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN0-14"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR96951"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-437300"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-437300"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-437300"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-437300"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-437300"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-437300"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-437300"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-437300"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-437300"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-437300"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-437300"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-437300"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28705"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28706"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28704"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28703"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08274"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn05212"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08273"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-28.9455"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_cu2_e" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_cu2_p" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_CU2tpp" name="R_CU2tpp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b2215"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0241"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0929"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b1377"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_CU2tpp" sboTerm="SBO:0000185" id="R_CU2tpp" name="Copper transport in via permease (no H+)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_CU2tpp">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/CU2tpp"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN0-14"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR96951"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-437300"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-437300"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-437300"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-437300"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-437300"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-437300"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-437300"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-437300"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-437300"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-437300"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-437300"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-437300"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28705"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28706"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28704"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28703"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08274"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn05212"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08273"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-28.379930135339706"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_cu2_p" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_cu2_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_CYSS" name="R_CYSS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3040"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_CYSS" sboTerm="SBO:0000176" id="R_CYSS" name="Cysteine synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_CYSS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/CYSS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:ACSERLY-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.5.1.47"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.5.1.65"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00897"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97007"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14829"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14831"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14830"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14832"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/1220"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00649"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-51.44573129385054"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.006910817221675682"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_acser_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2s_c" stoichiometry="1" constant="true"/>
@@ -1798,8 +20237,35 @@
           <speciesReference species="M_cys__L_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_CYSTL" name="R_CYSTL" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b2414"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2421"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_CYSTL" sboTerm="SBO:0000176" id="R_CYSTL" name="Cystathionine b-lyase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_CYSTL">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/CYSTL"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.4.1.8"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01286"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR96469"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13967"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13965"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13968"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13966"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/1501"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/2.0790249045567037"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.05411813241081512"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_cyst__L_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
@@ -1809,8 +20275,28 @@
           <speciesReference species="M_nh4_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_CYTBO3_4pp" name="R_CYTBO3_4pp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b1622"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b3008"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_CYTBO3_4pp" sboTerm="SBO:0000185" id="R_CYTBO3_4pp" name="Cytochrome oxidase bo3 (ubiquinol-8: 4 protons) (periplasm)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_CYTBO3_4pp">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/CYTBO3_4pp"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97036"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-24.263341267147382"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/6.403534584307678"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h_c" stoichiometry="4" constant="true"/>
           <speciesReference species="M_o2_c" stoichiometry="0.5" constant="true"/>
@@ -1821,8 +20307,39 @@
           <speciesReference species="M_q8_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_p" stoichiometry="4" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_CYTK1" name="R_CYTK1" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:and>
+            <fbc:geneProductRef fbc:geneProduct="G_b0429"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0430"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0431"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0432"/>
+          </fbc:and>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_CYTK1" sboTerm="SBO:0000176" id="R_CYTK1" name="Cytidylate kinase (CMP)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_CYTK1">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/CYTK1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN-11832"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.4.25"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.4.14"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00512"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97047"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11603"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11601"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11602"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11600"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00364"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/1.3597257854129339"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/6.38378239159465e-15"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_cmp_c" stoichiometry="1" constant="true"/>
@@ -1831,8 +20348,27 @@
           <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_cdp_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_D__LACt2pp" name="R_D_DASH_LACt2pp" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0910"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_D_LACt2pp" sboTerm="SBO:0000185" id="R_D_LACt2pp" name="D-lactate transport via proton symport (periplasm)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_D_LACt2pp">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/D_LACt2pp"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:TRANS-RXN0-515"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97838"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn10171"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09772"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08350"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h_p" stoichiometry="1" constant="true"/>
           <speciesReference species="M_lac__D_p" stoichiometry="1" constant="true"/>
@@ -1841,16 +20377,97 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_lac__D_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_D__LACtex" name="R_D_DASH_LACtex" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b3603"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2975"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_D_LACtex" sboTerm="SBO:0000185" id="R_D_LACtex" name="D-lactate transport via diffusion (extracellular to periplasm)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_D_LACtex">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/D_LACtex"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97840"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/12471"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08351"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_lac__D_e" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_lac__D_p" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_DADK" name="R_DADK" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b0241"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0929"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b1377"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2215"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_DADK" sboTerm="SBO:0000176" id="R_DADK" name="Deoxyadenylate kinase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_DADK">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/DADK"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:DEOXYADENYLATE-KINASE-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.4.11"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.4.13"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.4.3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01547"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR96117"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-74220"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-74220"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-110141"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-74220"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-110141"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-74220"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-110141"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-110141"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-110141"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-110141"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-74220"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-110141"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-74220"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-110141"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-74220"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-74220"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-110141"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-110141"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-110141"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-110141"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-74220"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-110141"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-74220"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-110141"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-74220"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-74220"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-74220"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-74220"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23100"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23103"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23102"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23101"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/314"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01127"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/2.6965019524203626"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.08542813264684129"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_damp_c" stoichiometry="1" constant="true"/>
@@ -1859,8 +20476,32 @@
           <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_dadp_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_DALAt2pp" name="R_DALAt2pp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0474"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_DALAt2pp" sboTerm="SBO:0000185" id="R_DALAt2pp" name="D-alanine transport in via proton symport (periplasm)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_DALAt2pp">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/DALAt2pp"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:TRANS-RXN-62A"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97135"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28903"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28904"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28906"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28905"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn05494"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08301"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-17.35893362256936"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_ala__D_p" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_p" stoichiometry="1" constant="true"/>
@@ -1869,8 +20510,33 @@
           <speciesReference species="M_ala__D_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_DAPDC" name="R_DAPDC" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b4208"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_DAPDC" sboTerm="SBO:0000176" id="R_DAPDC" name="Diaminopimelate decarboxylase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_DAPDC">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/DAPDC"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:DIAMINOPIMDECARB-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.1.1.20"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00451"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97141"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15101"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15104"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15102"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15103"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00313"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-18.380986603543533"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.06641042541576123"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_26dap__M_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
@@ -1879,16 +20545,56 @@
           <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_lys__L_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_DAPE" name="R_DAPE" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b2838"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_DAPE" sboTerm="SBO:0000176" id="R_DAPE" name="Diaminopimelate epimerase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_DAPE">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/DAPE"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:DIAMINOPIMEPIM-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/5.1.1.7"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R02735"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97143"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15396"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15395"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15393"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15394"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01974"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_26dap__LL_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_26dap__M_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_DASYN160" name="R_DASYN160" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3809"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_DASYN160" sboTerm="SBO:0000176" id="R_DASYN160" name="CDP-diacylglycerol synthetase (n-C16:0)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_DASYN160">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/DASYN160"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.7.41"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97157"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08309"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_ctp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
@@ -1898,8 +20604,25 @@
           <speciesReference species="M_cdpdhdecg_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_DASYN161" name="R_DASYN161" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0175"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_DASYN161" sboTerm="SBO:0000176" id="R_DASYN161" name="CDP-diacylglycerol synthetase (n-C16:1)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_DASYN161">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/DASYN161"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.7.41"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97159"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08310"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_ctp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
@@ -1909,8 +20632,27 @@
           <speciesReference species="M_cdpdhdec9eg_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_DB4PS" name="R_DB4PS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0175"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_DB4PS" sboTerm="SBO:0000176" id="R_DB4PS" name="3,4-Dihydroxy-2-butanone-4-phosphate synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_DB4PS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/DB4PS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.1.99.12"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R07281"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97178"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/9052"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn05040"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_ru5p__D_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
@@ -1919,8 +20661,34 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_forBIO_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_DBTS" name="R_DBTS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3041"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_DBTS" sboTerm="SBO:0000176" id="R_DBTS" name="Dethiobiotin synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_DBTS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/DBTS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:DETHIOBIOTIN-SYN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/6.3.3.3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R03182"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97180"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15807"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15808"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15806"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15805"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/3011"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn02277"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/12.40882772182016"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.23211870892605668"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
@@ -1932,8 +20700,35 @@
           <speciesReference species="M_h_c" stoichiometry="3" constant="true"/>
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_DDPA" name="R_DDPA" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0778"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_DDPA" sboTerm="SBO:0000176" id="R_DDPA" name="3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_DDPA">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/DDPA"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:DAHPSYN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.5.1.54"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01826"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97218"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MTU-964912"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14718"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14719"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14717"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14720"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/1910"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01332"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-74.70815572785642"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.009451881054321858"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_e4p_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
@@ -1943,8 +20738,36 @@
           <speciesReference species="M_2dda7p_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_DHAD1" name="R_DHAD1" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b2601"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0754"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b1704"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_DHAD1" sboTerm="SBO:0000176" id="R_DHAD1" name="Dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylbutanoate)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_DHAD1">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/DHAD1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:DIHYDROXYISOVALDEHYDRAT-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.2.1.9"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R04441"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97358"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24810"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24811"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24809"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24812"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-36.93540440204633"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.007016077319029897"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_23dhmb_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
@@ -1952,8 +20775,32 @@
           <speciesReference species="M_3mob_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_DHAD2" name="R_DHAD2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3771"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_DHAD2" sboTerm="SBO:0000176" id="R_DHAD2" name="Dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylpentanoate)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_DHAD2">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/DHAD2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:DIHYDROXYMETVALDEHYDRAT-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.2.1.9"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R05070"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97359"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27694"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27696"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27697"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27695"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-36.92781129377856"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.007016077319029897"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_23dhmp_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
@@ -1961,8 +20808,27 @@
           <speciesReference species="M_3mop_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_DHDPRy" name="R_DHDPRy" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3771"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_DHDPRy" sboTerm="SBO:0000176" id="R_DHDPRy" name="Dihydrodipicolinate reductase (NADPH)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_DHDPRy">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/DHDPRy"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.1.26"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR134418"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn02929"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-23.72527853739456"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.7400107817957331"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_23dhdp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
@@ -1972,8 +20838,31 @@
           <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_thdp_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_DHDPS" name="R_DHDPS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0031"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_DHDPS" sboTerm="SBO:0000176" id="R_DHDPS" name="Dihydrodipicolinate synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_DHDPS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/DHDPS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR125801"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14846"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14848"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14847"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14845"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/2256"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01644"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-125.09448315612727"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.32543059106864786"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_aspsa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
@@ -1983,8 +20872,47 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="2" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_DHFR" name="R_DHFR" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b2478"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_DHFR" sboTerm="SBO:0000176" id="R_DHFR" name="Dihydrofolate reductase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_DHFR">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/DHFR"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.5.1.3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00939"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97401"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-197972"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-197972"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-197972"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-197972"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-197972"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-197972"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-197972"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-197972"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-197972"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-197972"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-197972"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-197972"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-197972"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-197972"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-197972"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15010"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15009"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15012"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15011"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/100"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-21.643920522190342"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.5151245121898871"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_dhf_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
@@ -1994,8 +20922,37 @@
           <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_thf_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_DHFS" name="R_DHFS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b1606"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0048"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_DHFS" sboTerm="SBO:0000176" id="R_DHFS" name="Dihydrofolate synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_DHFS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/DHFS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:DIHYDROFOLATESYNTH-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/6.3.2.12"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/6.3.2.17"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R02237"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR140043"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23585"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23587"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23584"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23586"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01603"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-17.650994521771793"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.1394501682283058"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_dhpt_c" stoichiometry="1" constant="true"/>
@@ -2007,8 +20964,34 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_DHNPA2r" name="R_DHNPA2r" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b2315"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_DHNPA2r" sboTerm="SBO:0000176" id="R_DHNPA2r" name="Dihydroneopterin aldolase reversible" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_DHNPA2r">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/DHNPA2r"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:H2NEOPTERINALDOL-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.1.2.25"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R03504"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR125603"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10541"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10540"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10542"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10543"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/3293"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn02504"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/7.153919486844387"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.15659630514609155"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_dhnpt_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
@@ -2016,8 +20999,34 @@
           <speciesReference species="M_6hmhpt_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_gcald_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_DHORDfum" name="R_DHORDfum" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3058"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_DHORDfum" sboTerm="SBO:0000176" id="R_DHORDfum" name="Fumarate dependent DHORD" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_DHORDfum">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/DHORDfum"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN-9929"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.98.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01867"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97425"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/30059"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/30060"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/30062"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/30061"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/7103"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn13251"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-53.437469487323426"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.0052873930234643915"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_dhor__S_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_fum_c" stoichiometry="1" constant="true"/>
@@ -2027,7 +21036,49 @@
           <speciesReference species="M_succ_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction id="R_DHORTS" name="R_DHORTS" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+      <reaction metaid="meta_R_DHORTS" sboTerm="SBO:0000176" id="R_DHORTS" name="Dihydroorotase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_DHORTS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/DHORTS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:DIHYDROOROT-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.5.2.3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01993"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97428"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-73571"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-73571"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-73571"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-73571"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-73571"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-73571"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-73571"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-73571"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-73571"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-73571"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-73571"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-419465"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-73571"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-73571"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-73571"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-73571"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-73571"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-73571"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-73571"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24296"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24298"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24299"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24297"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/399"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01465"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-4.399737224965094"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/5.182486384480711e-15"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_dhor__S_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
@@ -2036,8 +21087,32 @@
           <speciesReference species="M_cbasp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_DHPPDA2" name="R_DHPPDA2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b1062"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_DHPPDA2" sboTerm="SBO:0000176" id="R_DHPPDA2" name="Diaminohydroxyphosphoribosylaminopryrimidine deaminase (25drapp)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_DHPPDA2">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/DHPPDA2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RIBOFLAVINSYNDEAM-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.5.4.26"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R03459"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97435"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21871"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21869"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21868"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21870"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/275.49483783622975"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-6.264428863588712"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_25drapp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
@@ -2047,8 +21122,33 @@
           <speciesReference species="M_5apru_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nh4_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_DHPS2" name="R_DHPS2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0414"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_DHPS2" sboTerm="SBO:0000176" id="R_DHPS2" name="Dihydropteroate synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_DHPS2">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/DHPS2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:H2PTEROATESYNTH-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.5.1.15"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R03067"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR140085"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/19950"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/19949"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/19952"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/19951"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn12954"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-65.28027867247413"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.5732473551302175"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_4abz_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_6hmhptpp_c" stoichiometry="1" constant="true"/>
@@ -2057,16 +21157,64 @@
           <speciesReference species="M_dhpt_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_DHPTDCs2" name="R_DHPTDCs2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3177"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_DHPTDCs2" sboTerm="SBO:0000176" id="R_DHPTDCs2" name="4,5-dihydroxy-2,3-pentanedione cyclization (spontaneous)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_DHPTDCs2">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/DHPTDCs2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN-10015"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97442"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/35157"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/35158"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/35155"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/35156"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-22.534986017733615"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.22502003727904984"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_dhptd_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_mdhdhf_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_DHQS" name="R_DHQS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_s0001"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_DHQS" sboTerm="SBO:0000176" id="R_DHQS" name="3-dehydroquinate synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_DHQS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/DHQS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:3-DEHYDROQUINATE-SYNTHASE-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.2.3.4"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R03083"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97447"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21968"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21970"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21971"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21969"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/2923"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn02212"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-150.94696256353689"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-3.224039166821935"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_2dda7p_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
@@ -2074,8 +21222,34 @@
           <speciesReference species="M_3dhq_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_DHQTi" name="R_DHQTi" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3389"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_DHQTi" sboTerm="SBO:0000176" id="R_DHQTi" name="3-dehydroquinate dehydratase, irreversible" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_DHQTi">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/DHQTi"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:3-DEHYDROQUINATE-DEHYDRATASE-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.2.1.10"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R03084"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97449"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21099"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21097"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21096"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21098"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/2924"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn02213"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-5.290093964781235"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/8.066464163292153e-16"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_3dhq_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
@@ -2083,8 +21257,52 @@
           <speciesReference species="M_3dhsk_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_DMATT" name="R_DMATT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b1693"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_DMATT" sboTerm="SBO:0000176" id="R_DMATT" name="Dimethylallyltranstransferase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_DMATT">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/DMATT"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:GPPSYN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.5.1.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01658"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97512"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-191322"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-191322"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-191322"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-191322"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-191322"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-191322"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-191322"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-191322"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-191322"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-191322"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-191322"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-191322"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-191322"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-191322"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-191322"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-191322"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-191322"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-191322"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22410"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22409"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22411"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22408"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/1793"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01213"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-79.0550800110813"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.15434947062441084"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_dmpp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ipdp_c" stoichiometry="1" constant="true"/>
@@ -2093,8 +21311,34 @@
           <speciesReference species="M_grdp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_DNMPPA" name="R_DNMPPA" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0421"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_DNMPPA" sboTerm="SBO:0000176" id="R_DNMPPA" name="Dihydroneopterin monophosphate dephosphorylase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_DNMPPA">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/DNMPPA"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.1.-"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R04621"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR126238"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/25308"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/25309"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/25306"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/25307"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn03168"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-9.626295506715394"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.07694739932867846"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_dhpmp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
@@ -2104,7 +21348,30 @@
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction id="R_DNTPPA" name="R_DNTPPA" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+      <reaction metaid="meta_R_DNTPPA" sboTerm="SBO:0000176" id="R_DNTPPA" name="Dihydroneopterin triphosphate pyrophosphatase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_DNTPPA">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/DNTPPA"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.1.67"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R04638"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97680"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/25302"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/25305"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/25303"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/25304"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/10428"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn03173"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-54.390348699462535"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.14158957768486014"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_ahdt_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
@@ -2114,8 +21381,54 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_DPCOAK" name="R_DPCOAK" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b0099"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b1865"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_DPCOAK" sboTerm="SBO:0000176" id="R_DPCOAK" name="Dephospho-CoA kinase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_DPCOAK">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/DPCOAK"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:DEPHOSPHOCOAKIN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.1.24"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00130"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97762"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-196773"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-196773"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-196773"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-196773"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-196773"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-196773"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-196773"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-196773"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-196773"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-196773"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-196773"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-196773"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-196773"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-196773"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-196773"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-196773"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-196773"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18248"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18245"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18247"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18246"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/48"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00100"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/6.449964129152477"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-9.103828801926284e-15"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_dpcoa_c" stoichiometry="1" constant="true"/>
@@ -2125,8 +21438,34 @@
           <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_DPR" name="R_DPR" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0103"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_DPR" sboTerm="SBO:0000176" id="R_DPR" name="2-dehydropantoate 2-reductase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_DPR">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/DPR"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:2-DEHYDROPANTOATE-REDUCT-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.169"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R02472"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97779"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16233"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16234"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16235"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16236"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/2405"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01790"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-18.584442537554082"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/1.582067810090848e-15"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_2dhp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
@@ -2136,8 +21475,38 @@
           <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pant__R_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_DTMPK" name="R_DTMPK" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b0425"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b3774"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_DTMPK" sboTerm="SBO:0000176" id="R_DTMPK" name="DTMP kinase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_DTMPK">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/DTMPK"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:DTMPKI-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.4.13"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.4.12"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.4.9"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R02094"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97804"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13520"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13518"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13517"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13519"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01513"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-2.277014362551995"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-5.717648576819556e-15"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_dtmp_c" stoichiometry="1" constant="true"/>
@@ -2146,8 +21515,35 @@
           <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_dtdp_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_DURIK1" name="R_DURIK1" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b1098"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_DURIK1" sboTerm="SBO:0000176" id="R_DURIK1" name="Deoxyuridine kinase (ATP:Deoxyuridine)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_DURIK1">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/DURIK1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:DURIDKI-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.1.145"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.1.21"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R02099"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97817"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28209"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28206"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28207"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28208"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/500"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01518"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-12.2709405515061"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.07243488600608591"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_duri_c" stoichiometry="1" constant="true"/>
@@ -2157,8 +21553,37 @@
           <speciesReference species="M_dump_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_DURIPP" name="R_DURIPP" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b1238"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_DURIPP" sboTerm="SBO:0000176" id="R_DURIPP" name="Deoxyuridine phosphorylase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_DURIPP">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/DURIPP"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:URA-PHOSPH-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.4.2.3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.4.2.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.4.2.4"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.4.2.2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R02484"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97818"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22825"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22824"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22827"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22826"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/511"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01799"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/4.290393033594938"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.042563279283717614"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_duri_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
@@ -2167,8 +21592,37 @@
           <speciesReference species="M_2dr1p_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ura_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_DXPRIi" name="R_DXPRIi" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b4382"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b4384"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_DXPRIi" sboTerm="SBO:0000176" id="R_DXPRIi" name="1-deoxy-D-xylulose reductoisomerase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_DXPRIi">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/DXPRIi"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:DXPREDISOM-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.267"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R05688"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97830"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13720"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13717"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13718"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13719"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/5284"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn03958"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-15.609678823580794"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.08106522645602166"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_dxyl5p_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
@@ -2178,8 +21632,33 @@
           <speciesReference species="M_2me4p_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_DXPS" name="R_DXPS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0173"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_DXPS" sboTerm="SBO:0000176" id="R_DXPS" name="1-deoxy-D-xylulose 5-phosphate synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_DXPS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/DXPS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:DXS-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.2.1.7"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R05636"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97831"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12605"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12607"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12608"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12606"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn03909"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-31.682374758613435"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.15522271726084114"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_g3p_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
@@ -2189,8 +21668,34 @@
           <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_dxyl5p_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_E4PD" name="R_E4PD" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0420"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_E4PD" sboTerm="SBO:0000176" id="R_E4PD" name="Erythrose 4-phosphate dehydrogenase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_E4PD">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/E4PD"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:ERYTH4PDEHYDROG-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.2.1.72"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01825"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97842"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12058"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12057"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12059"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12056"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/1909"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01331"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-45.93247167124309"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.009680599820112601"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_e4p_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
@@ -2201,8 +21706,53 @@
           <speciesReference species="M_h_c" stoichiometry="2" constant="true"/>
           <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ECOAH1" name="R_ECOAH1" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b2927"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b1779"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ECOAH1" sboTerm="SBO:0000176" id="R_ECOAH1" name="3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ECOAH1">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ECOAH1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN-11667"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.2.1.150"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.2.1.17"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.2.1.55"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R03026"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97883"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-77314"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-77314"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-77314"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-77314"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-77314"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-77314"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-77314"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-77314"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-77314"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-77314"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-77314"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-77314"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-77314"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-77314"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/26559"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/26558"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/26560"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/26561"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/2876"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn02167"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/2.5423548763321406"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-4.855491009259083e-15"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_3hbcoa_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
@@ -2210,8 +21760,52 @@
           <speciesReference species="M_b2coa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ECOAH2" name="R_ECOAH2" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b3846"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2341"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ECOAH2" sboTerm="SBO:0000176" id="R_ECOAH2" name="3-hydroxyacyl-CoA dehydratase (3-hydroxyhexanoyl-CoA)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ECOAH2">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ECOAH2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN-12567"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.2.1.17"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.2.1.74"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R04749"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97886"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-77325"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-77325"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-77325"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-77325"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-77325"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-77325"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-77325"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-77325"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-77325"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-77325"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-77325"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-77325"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-77325"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-77325"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/30548"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/30547"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/30550"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/30549"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/4405"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn03250"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/0.1308708250719519"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-9.992007221626409e-15"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_3hhcoa_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
@@ -2219,8 +21813,51 @@
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_hx2coa_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ECOAH3" name="R_ECOAH3" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b3846"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2341"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ECOAH3" sboTerm="SBO:0000176" id="R_ECOAH3" name="3-hydroxyacyl-CoA dehydratase (3-hydroxyoctanoyl-CoA)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ECOAH3">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ECOAH3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.2.1.17"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.2.1.74"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R04746"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97888"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-77333"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-77333"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-77333"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-77333"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-77333"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-77333"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-77333"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-77333"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-77333"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-77333"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-77333"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-77333"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-77333"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-77333"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/31202"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/31200"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/31201"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/31199"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/4402"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn03247"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-0.4327423509625987"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.03188837580952064"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_3hocoa_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
@@ -2228,8 +21865,52 @@
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_oc2coa_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ECOAH4" name="R_ECOAH4" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b3846"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2341"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ECOAH4" sboTerm="SBO:0000176" id="R_ECOAH4" name="3-hydroxyacyl-CoA dehydratase (3-hydroxydecanoyl-CoA)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ECOAH4">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ECOAH4"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN-13616"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.2.1.17"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.2.1.74"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R04744"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97889"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-77344"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-77344"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-77344"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-77344"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-77344"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-77344"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-77344"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-77344"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-77344"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-77344"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-77344"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-77344"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-77344"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-77344"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/31193"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/31191"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/31194"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/31192"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/4400"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn03245"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-0.4327423509628687"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.031888375809520614"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_3hdcoa_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
@@ -2237,8 +21918,51 @@
           <speciesReference species="M_dc2coa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ECOAH5" name="R_ECOAH5" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b3846"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2341"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ECOAH5" sboTerm="SBO:0000176" id="R_ECOAH5" name="3-hydroxyacyl-CoA dehydratase (3-hydroxydodecanoyl-CoA)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ECOAH5">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ECOAH5"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.2.1.17"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.2.1.74"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R04170"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97890"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-77256"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-77256"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-77256"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-77256"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-77256"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-77256"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-77256"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-77256"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-77256"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-77256"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-77256"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-77256"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-77256"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-77256"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/31078"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/31075"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/31077"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/31076"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/3890"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn02911"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-0.43274235096195923"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.031888375809520836"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_3hddcoa_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
@@ -2246,8 +21970,49 @@
           <speciesReference species="M_dd2coa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ECOAH6" name="R_ECOAH6" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b3846"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2341"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ECOAH6" sboTerm="SBO:0000176" id="R_ECOAH6" name="3-hydroxyacyl-CoA dehydratase (3-hydroxytetradecanoyl-CoA)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ECOAH6">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ECOAH6"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN-14273"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.2.1.17"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.2.1.74"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R04740"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97891"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-77277"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-77277"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-77277"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-77277"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-77277"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-77277"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-77277"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-77277"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-77277"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-77277"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-77277"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/31173"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/31171"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/31174"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/31172"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/4396"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn03241"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-0.432742350962144"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.03188837580952064"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_3htdcoa_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
@@ -2255,8 +22020,49 @@
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_td2coa_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ECOAH7" name="R_ECOAH7" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b3846"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2341"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ECOAH7" sboTerm="SBO:0000176" id="R_ECOAH7" name="3-hydroxyacyl-CoA dehydratase (3-hydroxyhexadecanoyl-CoA)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ECOAH7">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ECOAH7"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN-14272"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.2.1.17"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.2.1.74"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R04738"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97892"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-77301"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-77301"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-77301"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-77301"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-77301"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-77301"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-77301"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-77301"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-77301"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-77301"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-77301"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/31163"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/31166"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/31164"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/31165"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/4394"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn03240"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-0.432742350962144"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.03188837580952053"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_3hhdcoa_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
@@ -2264,8 +22070,37 @@
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_hdd2coa_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_EDA" name="R_EDA" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b3846"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2341"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_EDA" sboTerm="SBO:0000176" id="R_EDA" name="2-dehydro-3-deoxy-phosphogluconate aldolase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_EDA">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/EDA"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:KDPGALDOL-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.1.2.14"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.1.2.55"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R05605"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97897"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17092"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17091"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17089"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17090"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn03884"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/16.12862028232179"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/4.28650170913869e-15"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_2ddg6p_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
@@ -2273,8 +22108,33 @@
           <speciesReference species="M_g3p_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_EDD" name="R_EDD" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b1850"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_EDD" sboTerm="SBO:0000176" id="R_EDD" name="6-phosphogluconate dehydratase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_EDD">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/EDD"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:PGLUCONDEHYDRAT-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.2.1.12"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R02036"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97898"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17280"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17278"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17277"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17279"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01477"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-42.92710774026209"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.003835339539805975"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_6pgc_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
@@ -2282,8 +22142,25 @@
           <speciesReference species="M_2ddg6p_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_EGMEACPR" name="R_EGMEACPR" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b1851"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_EGMEACPR" sboTerm="SBO:0000176" id="R_EGMEACPR" name="Enoylglutaryl-[ACP] methyl ester reductase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_EGMEACPR">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/EGMEACPR"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.1.10"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R10118"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97906"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_egmeACP_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
@@ -2293,8 +22170,72 @@
           <speciesReference species="M_gmeACP_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ENO" name="R_ENO" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b1288"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ENO" sboTerm="SBO:0000176" id="R_ENO" name="Enolase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ENO">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ENO"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:2PGADEHYDRAT-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.2.1.11"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00658"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97932"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-71660"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-70494"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-71660"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-71660"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-352981"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-70494"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-70494"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-70494"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-71660"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-353044"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-71660"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-70494"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-71660"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-71660"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-70494"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-70494"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-71660"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-70494"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-70494"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-70494"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-70494"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-70494"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-71660"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-71660"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-71660"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-70494"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-71660"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-70494"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-71660"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-71660"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-71660"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-70494"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-70494"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-70494"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-71660"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-71660"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-70494"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-71660"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10166"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10165"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10164"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10167"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/8"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00459"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-3.958777093313813"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0003805228007028316"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_2pg_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
@@ -2302,8 +22243,25 @@
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pep_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_EPMEACPR" name="R_EPMEACPR" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b2779"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_EPMEACPR" sboTerm="SBO:0000176" id="R_EPMEACPR" name="Enoylpimeloyl-[ACP] methyl ester reductase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_EPMEACPR">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/EPMEACPR"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.1.10"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R10122"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97945"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_epmeACP_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
@@ -2313,24 +22271,102 @@
           <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pmeACP_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ETOHtex" name="R_ETOHtex" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b1288"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ETOHtex" sboTerm="SBO:0000185" id="R_ETOHtex" name="Ethanol transport via diffusion (extracellular to periplasm)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ETOHtex">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ETOHtex"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:TRANS-RXN0-546"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97980"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/35269"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/35267"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/35270"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/35268"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09683"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08428"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09764"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/0.0"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/1.4901161193847656e-08"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_etoh_e" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_etoh_p" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ETOHtrpp" name="R_ETOHtrpp" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b0241"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0929"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b1377"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2215"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ETOHtrpp" sboTerm="SBO:0000185" id="R_ETOHtrpp" name="Ethanol reversible transport via diffusion (periplasm)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ETOHtrpp">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ETOHtrpp"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:TRANS-RXN0-546"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97980"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/35269"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/35267"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/35270"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/35268"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09683"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08428"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09764"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-3.552713678800501e-15"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/1.4901161193847656e-08"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_etoh_p" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_etoh_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_F6PA" name="R_F6PA" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_s0001"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_F6PA" sboTerm="SBO:0000176" id="R_F6PA" name="Fructose 6-phosphate aldolase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_F6PA">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/F6PA"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN0-313"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.1.2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR99075"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28002"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28003"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28004"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28005"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/15.842299958261492"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.02436004613709355"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_f6p_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
@@ -2338,8 +22374,27 @@
           <speciesReference species="M_dha_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_g3p_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_FACOAE120" name="R_FACOAE120" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b0825"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b3946"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_FACOAE120" sboTerm="SBO:0000176" id="R_FACOAE120" name="Fatty-acid-CoA thioesterase (dodecanoate)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_FACOAE120">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/FACOAE120"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.1.2.2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR99128"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_ddcacoa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
@@ -2349,8 +22404,35 @@
           <speciesReference species="M_ddca_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_FACOAE160" name="R_FACOAE160" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0452"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_FACOAE160" sboTerm="SBO:0000176" id="R_FACOAE160" name="Fatty-acid-CoA thioesterase (hexadecanoate)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_FACOAE160">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/FACOAE160"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:PALMITOYL-COA-HYDROLASE-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.1.2.22"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.1.2.2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01274"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR99131"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16648"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16645"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16646"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16647"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/1490"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00943"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-26.11254357759816"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.6094015685667805"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pmtcoa_c" stoichiometry="1" constant="true"/>
@@ -2360,8 +22442,23 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_hdca_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_FACOAE161" name="R_FACOAE161" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0452"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_FACOAE161" sboTerm="SBO:0000176" id="R_FACOAE161" name="Fatty-acid-CoA thioesterase (hexadecenoate)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_FACOAE161">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/FACOAE161"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR99132"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_hdcoa_c" stoichiometry="1" constant="true"/>
@@ -2371,8 +22468,36 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_hdcea_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_FADRx" name="R_FADRx" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0452"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_FADRx" sboTerm="SBO:0000176" id="R_FADRx" name="FAD reductase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_FADRx">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/FADRx"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN-8506"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.5.1.37"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.5.1.36"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.5.1.45"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R09748"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR99215"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/30150"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/30149"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/30147"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/30148"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/7290"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08458"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-21.827336790166783"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.009045043365790262"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_fad_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
@@ -2382,8 +22507,33 @@
           <speciesReference species="M_fadh2_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_FBA" name="R_FBA" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3844"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_FBA" sboTerm="SBO:0000176" id="R_FBA" name="Fructose-bisphosphate aldolase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_FBA">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/FBA"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.1.2.13"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01068"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR99459"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14729"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14732"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14731"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14730"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/1338"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00786"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/23.730617476453176"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0016176049400735536"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_fdp_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
@@ -2391,8 +22541,35 @@
           <speciesReference species="M_dhap_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_g3p_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_FBP" name="R_FBP" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b2097"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b1773"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2925"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_FBP" sboTerm="SBO:0000176" id="R_FBP" name="Fructose-bisphosphatase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_FBP">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/FBP"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.1.3.11"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR99465"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11067"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11065"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11066"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11064"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/2084"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-7.648891869478234"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.026499241127634125"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_fdp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
@@ -2401,8 +22578,34 @@
           <speciesReference species="M_f6p_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_FCLT" name="R_FCLT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b3925"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b4232"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2930"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_FCLT" sboTerm="SBO:0000176" id="R_FCLT" name="Ferrochelatase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_FCLT">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/FCLT"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:PROTOHEMEFERROCHELAT-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.99.1.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00310"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR99471"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22585"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22586"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22584"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22587"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_fe2_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ppp9_c" stoichiometry="1" constant="true"/>
@@ -2411,24 +22614,106 @@
           <speciesReference species="M_h_c" stoichiometry="2" constant="true"/>
           <speciesReference species="M_pheme_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_FE2tex" name="R_FE2tex" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0475"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_FE2tex" sboTerm="SBO:0000185" id="R_FE2tex" name="Iron (II) transport via diffusion (extracellular to periplasm)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_FE2tex">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/FE2tex"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:TRANS-RXN-8"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR99505"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28488"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28487"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28489"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28486"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08476"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08475"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn13286"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn10963"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-28.9455"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_fe2_e" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_fe2_p" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_FE2tpp" name="R_FE2tpp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b0241"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0929"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b1377"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2215"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_FE2tpp" sboTerm="SBO:0000185" id="R_FE2tpp" name="Iron (+2) transport in via permease (no H+)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_FE2tpp">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/FE2tpp"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:TRANS-RXN-8"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR99505"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28488"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28487"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28489"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28486"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08476"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08475"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn13286"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn10963"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-28.9455"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_fe2_p" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_fe2_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_FE3abcpp" name="R_FE3abcpp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3040"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_FE3abcpp" sboTerm="SBO:0000185" id="R_FE3abcpp" name="Iron (III) transport via ABC system (periplasm to cytoplasm)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_FE3abcpp">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/FE3abcpp"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:3.6.3.30-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.30"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR99525"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12335#1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12332#1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12334#1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12333#1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn05195"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08477"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-72.63686791245327"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.3042778552990978"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
@@ -2441,15 +22726,71 @@
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction id="R_FE3tex" name="R_FE3tex" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+      <reaction metaid="meta_R_FE3tex" sboTerm="SBO:0000185" id="R_FE3tex" name="Iron (III) transport via diffusion (extracellular to periplasm)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_FE3tex">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/FE3tex"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR99522"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-442368"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-442368"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-442368"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-442368"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-442368"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-442368"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-442368"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-442368"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/34973"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/34972"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/34974"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/34971"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn05292"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08492"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-43.41824999999999"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_fe3_e" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_fe3_p" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_FHL" name="R_FHL" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b0241"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0929"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b1377"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2215"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_FHL" sboTerm="SBO:0000176" id="R_FHL" name="Formate-hydrogen lyase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_FHL">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/FHL"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:FHLMULTI-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR99594"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27611"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27610"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27613"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27612"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08518"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/21.377405485181256"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.0009474335395007466"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_for_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
@@ -2458,8 +22799,46 @@
           <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_FLDR2" name="R_FLDR2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b4079"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2481"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2482"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2483"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2484"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2485"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2486"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2487"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2488"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2489"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2490"/>
+            </fbc:and>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b4079"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2719"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2720"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2721"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2722"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2723"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2724"/>
+            </fbc:and>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_FLDR2" sboTerm="SBO:0000176" id="R_FLDR2" name="Flavodoxin reductase (NADPH)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_FLDR2">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/FLDR2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR99599"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_flxso_c" stoichiometry="2" constant="true"/>
           <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
@@ -2469,8 +22848,60 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_FMNAT" name="R_FMNAT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b0684"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b3924"/>
+            </fbc:and>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b2895"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b3924"/>
+            </fbc:and>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_FMNAT" sboTerm="SBO:0000176" id="R_FMNAT" name="FMN adenylyltransferase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_FMNAT">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/FMNAT"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:FADSYN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.7.2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00161"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95501"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-196929"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-196929"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-196929"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-196929"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-196929"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-196929"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-196929"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-196929"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-196929"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-196929"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-196929"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-196929"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-196929"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-196929"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-196929"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-196929"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-196929"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17239"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17240"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17238"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17237"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/390"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00122"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-11.149265463648291"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.1323720941335833"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_fmn_c" stoichiometry="1" constant="true"/>
@@ -2480,24 +22911,110 @@
           <speciesReference species="M_fad_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_FORtex" name="R_FORtex" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0025"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_FORtex" sboTerm="SBO:0000185" id="R_FORtex" name="Formate transport via diffusion (extracellular to periplasm)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_FORtex">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/FORtex"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:TRANS-RXN-1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR99620"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-6803255"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29681"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29680"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29682"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29679"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/12483"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09754"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08525"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09682"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08526"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/14.47275"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_for_e" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_for_p" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_FORtppi" name="R_FORtppi" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b0241"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0929"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b1377"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2215"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_FORtppi" sboTerm="SBO:0000185" id="R_FORtppi" name="Formate transport via diffusion (cytoplasm to periplasm)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_FORtppi">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/FORtppi"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:TRANS-RXN-1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR99620"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-6803255"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29681"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29680"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29682"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29679"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/12483"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09754"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08525"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09682"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08526"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-14.474375113463449"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_for_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_for_p" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_FRD2" name="R_FRD2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b0904"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2492"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_FRD2" sboTerm="SBO:0000176" id="R_FRD2" name="Fumarate reductase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_FRD2">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/FRD2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR99637"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29216"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29215"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29218"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29217"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08527"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-34.39974284200326"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-1.143927906984522"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_fum_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_mql8_c" stoichiometry="1" constant="true"/>
@@ -2506,8 +23023,32 @@
           <speciesReference species="M_mqn8_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_succ_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_FRD3" name="R_FRD3" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:and>
+            <fbc:geneProductRef fbc:geneProduct="G_b4151"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b4152"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b4153"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b4154"/>
+          </fbc:and>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_FRD3" sboTerm="SBO:0000176" id="R_FRD3" name="Fumarate reductase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_FRD3">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/FRD3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.99.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR99639"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08528"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-11.986850770517947"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-1.2435694904622896"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_2dmmql8_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_fum_c" stoichiometry="1" constant="true"/>
@@ -2516,8 +23057,69 @@
           <speciesReference species="M_2dmmq8_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_succ_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_FTHFLi" name="R_FTHFLi" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:and>
+            <fbc:geneProductRef fbc:geneProduct="G_b4151"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b4152"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b4153"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b4154"/>
+          </fbc:and>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_FTHFLi" sboTerm="SBO:0000176" id="R_FTHFLi" name="Formate-tetrahydrofolate ligase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_FTHFLi">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/FTHFLi"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/6.3.4.3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00943"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR99672"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-5696839"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-6801456"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-6801456"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-6801456"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-6801456"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-5696839"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-5696839"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-5696839"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-5696839"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-5696839"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-5696839"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-5696839"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-5696839"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-6801456"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-6801456"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-5696839"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-5696839"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-6801456"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-5696839"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-6801456"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-5696839"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-6801456"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-6801456"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-6801456"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-6801456"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-5696839"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-6801456"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-6801456"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-5696839"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-5696839"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-6801456"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-6801456"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-5696839"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-6801456"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/20221"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/20223"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/20224"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/20222"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/51"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_thf_c" stoichiometry="1" constant="true"/>
@@ -2529,7 +23131,66 @@
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction id="R_FUM" name="R_FUM" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+      <reaction metaid="meta_R_FUM" sboTerm="SBO:0000176" id="R_FUM" name="Fumarase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_FUM">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/FUM"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:FUMHYDR-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.2.1.2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01082"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR99705"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-451033"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-70982"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-70982"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-451033"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-70982"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-451033"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-451033"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-70982"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-70982"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-70982"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-451033"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-451033"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-451033"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-451033"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-451033"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-70982"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-70982"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-451033"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-70982"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-70982"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-451033"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-373141"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-451033"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-451033"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-70982"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-373145"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-70982"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-451033"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-451033"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-70982"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-451033"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-70982"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-70982"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-70982"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-451033"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-70982"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12463"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12461"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12462"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12460"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/256"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00799"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-3.4332000193047065"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/2.432071022525663e-06"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_fum_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
@@ -2537,8 +23198,33 @@
         <listOfProducts>
           <speciesReference species="M_mal__L_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_G1PACT" name="R_G1PACT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b1612"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b4122"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b1611"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_G1PACT" sboTerm="SBO:0000176" id="R_G1PACT" name="Glucosamine-1-phosphate N-acetyltransferase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_G1PACT">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/G1PACT"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.1.4"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.1.157"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR99841"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/4940"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn03638"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-18.791675152194784"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.28283306529924596"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_accoa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_gam1p_c" stoichiometry="1" constant="true"/>
@@ -2548,16 +23234,66 @@
           <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_G1SAT" name="R_G1SAT" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3730"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_G1SAT" sboTerm="SBO:0000176" id="R_G1SAT" name="Glutamate-1-semialdehyde aminotransferase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_G1SAT">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/G1SAT"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:GSAAMINOTRANS-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/5.4.3.8"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R02272"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR99850"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14265"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14267"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14268"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14266"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01629"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-8.983609154430042"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.04202730783451991"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_glu1sa_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_5aop_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_G3PD2" name="R_G3PD2" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0154"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_G3PD2" sboTerm="SBO:0000176" id="R_G3PD2" name="Glycerol-3-phosphate dehydrogenase (NADP)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_G3PD2">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/G3PD2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.94"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00844"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR99877"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11096"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11099"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11098"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11097"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/1184"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00612"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/25.354912359386617"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.00036751500156961825"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_glyc3p_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
@@ -2567,8 +23303,30 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_G3PD5" name="R_G3PD5" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3608"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_G3PD5" sboTerm="SBO:0000176" id="R_G3PD5" name="Glycerol-3-phosphate dehydrogenase (ubiquinone-8)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_G3PD5">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/G3PD5"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR99880"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28753"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28752"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28754"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28751"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08556"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-109.02468839946931"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.13615997110502498"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_glyc3p_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_q8_c" stoichiometry="1" constant="true"/>
@@ -2577,8 +23335,42 @@
           <speciesReference species="M_dhap_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_q8h2_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_G5SADs" name="R_G5SADs" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b2241"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2242"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2243"/>
+            </fbc:and>
+            <fbc:geneProductRef fbc:geneProduct="G_b3426"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_G5SADs" sboTerm="SBO:0000176" id="R_G5SADs" name="L-glutamate 5-semialdehyde dehydratase (spontaneous)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_G5SADs">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/G5SADs"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:SPONTPRO-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R03314"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR99897"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-70655"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-70667"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28237"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28234"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28235"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28236"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn11220"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn02374"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-34.02481393338168"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.5566027124014025"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_glu5sa_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
@@ -2587,8 +23379,34 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_G5SD" name="R_G5SD" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_s0001"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_G5SD" sboTerm="SBO:0000176" id="R_G5SD" name="Glutamate-5-semialdehyde dehydrogenase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_G5SD">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/G5SD"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:GLUTSEMIALDEHYDROG-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.2.1.41"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R03313"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR99896"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/19541"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/19543"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/19544"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/19542"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/3127"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn02373"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-11.15343980062977"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.010802149123604119"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_glu5p_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
@@ -2599,8 +23417,36 @@
           <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_G6PDH2r" name="R_G6PDH2r" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0243"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_G6PDH2r" sboTerm="SBO:0000176" id="R_G6PDH2r" name="Glucose 6-phosphate dehydrogenase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_G6PDH2r">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/G6PDH2r"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:GLU6PDEHYDROG-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.363"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.49"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00835"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR99907"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15842"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15843"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15841"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15844"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/1176"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/6509"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00604"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-4.122421051612719"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0014247970315401925"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_g6p_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
@@ -2610,8 +23456,73 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_GAPD" name="R_GAPD" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b1852"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_GAPD" sboTerm="SBO:0000176" id="R_GAPD" name="Glyceraldehyde-3-phosphate dehydrogenase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_GAPD">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/GAPD"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:GAPOXNPHOSPHN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.2.1.12"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.2.1.59"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01061"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100040"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-70482"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-70449"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-70482"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-70449"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-70449"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-70449"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-70482"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-70449"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-70482"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-70449"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-70482"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-352956"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-70449"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-70449"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-70482"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-70449"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-70482"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-70449"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-352921"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-70449"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-70482"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-70482"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-70482"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-70482"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-70482"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-70449"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-70449"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-70482"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-70482"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-70449"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-70482"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-70449"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-70482"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-70449"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-70449"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-70482"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-70449"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-70482"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10303"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10300"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10302"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10301"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/7844"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00781"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/3.650197882139537"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0003039626920273708"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_g3p_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
@@ -2622,8 +23533,31 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_GARFT" name="R_GARFT" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b1779"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_GARFT" sboTerm="SBO:0000176" id="R_GARFT" name="Phosphoribosylglycinamide formyltransferase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_GARFT">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/GARFT"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.1.2.2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R04325"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR99623"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15053"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15054"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15055"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15056"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/4.647483935076366"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-1.1893663025744612"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_10fthf_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_gar_c" stoichiometry="1" constant="true"/>
@@ -2633,8 +23567,34 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_thf_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_GCALDD" name="R_GCALDD" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b2500"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_GCALDD" sboTerm="SBO:0000176" id="R_GCALDD" name="Glycolaldehyde dehydrogenase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_GCALDD">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/GCALDD"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:GLYCOLALD-DEHYDROG-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.2.1.21"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01333"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100060"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/20004"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/20002"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/20001"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/20003"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/434"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00979"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-60.821637390233036"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.01261187675585651"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_gcald_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
@@ -2645,8 +23605,27 @@
           <speciesReference species="M_h_c" stoichiometry="2" constant="true"/>
           <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_GF6PTA" name="R_GF6PTA" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b1415"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_GF6PTA" sboTerm="SBO:0000176" id="R_GF6PTA" name="Glutamine-fructose-6-phosphate transaminase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_GF6PTA">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/GF6PTA"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:L-GLN-FRUCT-6-P-AMINOTRANS-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.6.1.16"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100107"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-19.25415444859459"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.026118380844243214"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_f6p_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_gln__L_c" stoichiometry="1" constant="true"/>
@@ -2655,8 +23634,31 @@
           <speciesReference species="M_gam6p_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_GHMT2r" name="R_GHMT2r" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3729"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_GHMT2r" sboTerm="SBO:0000176" id="R_GHMT2r" name="Glycine hydroxymethyltransferase, reversible" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_GHMT2r">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/GHMT2r"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.1.2.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00945"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100142"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15481"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15483"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15484"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15482"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-10.160025725132982"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.515820051413129"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_ser__L_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_thf_c" stoichiometry="1" constant="true"/>
@@ -2666,8 +23668,34 @@
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_mlthf_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_GK1" name="R_GK1" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b2551"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_GK1" sboTerm="SBO:0000176" id="R_GK1" name="Guanylate kinase (GMP:ATP)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_GK1">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/GK1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:GUANYL-KIN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.4.8"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00332"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100144"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/20783"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/20782"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/20780"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/20781"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/77"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00239"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-0.8691675587367627"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/9.769962616701378e-15"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_gmp_c" stoichiometry="1" constant="true"/>
@@ -2676,8 +23704,27 @@
           <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_gdp_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_GLCptspp" name="R_GLCptspp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3648"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_GLCptspp" sboTerm="SBO:0000185" id="R_GLCptspp" name="D-glucose transport via PEP:Pyr PTS (periplasm)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_GLCptspp">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/GLCptspp"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100237"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08612"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn05226"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-45.08377546078669"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.6035605263342846"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_pep_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_glc__D_p" stoichiometry="1" constant="true"/>
@@ -2686,8 +23733,48 @@
           <speciesReference species="M_g6p_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_GLCt2pp" name="R_GLCt2pp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b2417"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b1621"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2415"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2416"/>
+            </fbc:and>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b2417"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b1101"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2415"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2416"/>
+            </fbc:and>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b1817"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b1818"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b1819"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2415"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2416"/>
+            </fbc:and>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_GLCt2pp" sboTerm="SBO:0000185" id="R_GLCt2pp" name="D-glucose transport in via proton symport (periplasm)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_GLCt2pp">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/GLCt2pp"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN0-7077"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100238"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08616"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn05573"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-17.32573901764095"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_glc__D_p" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_p" stoichiometry="1" constant="true"/>
@@ -2696,8 +23783,23 @@
           <speciesReference species="M_glc__D_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_GLCtex" name="R_GLCtex" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b2943"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_GLCtex" id="R_GLCtex" name="R_GLCtex" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_GLCtex">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/0.0"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_glc__D_e" stoichiometry="1" constant="true"/>
         </listOfReactants>
@@ -2705,7 +23807,46 @@
           <speciesReference species="M_glc__D_p" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction id="R_GLNS" name="R_GLNS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+      <reaction metaid="meta_R_GLNS" sboTerm="SBO:0000176" id="R_GLNS" name="Glutamine synthetase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_GLNS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/GLNS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:GLUTAMINESYN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/6.3.1.2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00253"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100024"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-70606"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-70606"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-70606"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-70606"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-70606"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-70606"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-70606"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-70606"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-70606"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-70606"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-70606"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-70606"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-70606"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-70606"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-70606"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-70606"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16172"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16171"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16169"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16170"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/760"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00187"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-12.51012213161539"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.00018405661297110198"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
@@ -2717,8 +23858,37 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_GLU5K" name="R_GLU5K" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b3870"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b1297"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_GLU5K" sboTerm="SBO:0000176" id="R_GLU5K" name="Glutamate 5-kinase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_GLU5K">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/GLU5K"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:GLUTKIN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.2.11"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00239"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100277"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14878"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14880"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14877"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14879"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/752"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00179"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/29.820033220353764"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.021213039867449827"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
@@ -2727,8 +23897,36 @@
           <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_glu5p_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_GLUDy" name="R_GLUDy" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0242"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_GLUDy" sboTerm="SBO:0000176" id="R_GLUDy" name="Glutamate dehydrogenase (NADP)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_GLUDy">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/GLUDy"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:GLUTDEHYD-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.4.1.13"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.4.1.3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.4.1.4"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00248"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100086"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11613"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11614"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11612"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11615"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/757"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00184"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/35.98942294830235"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.0007128191204790564"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
@@ -2740,8 +23938,52 @@
           <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nh4_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_GLUPRT" name="R_GLUPRT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b1761"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_GLUPRT" sboTerm="SBO:0000176" id="R_GLUPRT" name="Glutamine phosphoribosyldiphosphate amidotransferase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_GLUPRT">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/GLUPRT"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:PRPPAMIDOTRANS-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.4.2.14"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01072"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100287"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-73815"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-73815"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-73815"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-73815"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-73815"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-419152"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-73815"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-73815"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-73815"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-73815"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-73815"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-73815"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-73815"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-73815"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-73815"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-73815"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-73815"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-73815"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14905"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14908"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14906"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14907"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/114"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00790"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-61.7867597635489"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.06109592017476864"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_gln__L_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
@@ -2752,16 +23994,61 @@
           <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pram_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_GLUR" name="R_GLUR" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b2312"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_GLUR" sboTerm="SBO:0000176" id="R_GLUR" name="Glutamate racemase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_GLUR">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/GLUR"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:GLUTRACE-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/5.1.1.3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00260"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100288"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12813"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12814"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12815"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12816"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/765"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00193"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-0.41339241828978857"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-1.961737283797142e-05"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_glu__D_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_GLUTRR" name="R_GLUTRR" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3967"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_GLUTRR" sboTerm="SBO:0000176" id="R_GLUTRR" name="Glutamyl-tRNA reductase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_GLUTRR">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/GLUTRR"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.2.1.70"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R04109"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100294"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/9145"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn06591"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_glutrna_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
@@ -2772,8 +24059,31 @@
           <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_trnaglu_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_GLUTRS" name="R_GLUTRS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b1210"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_GLUTRS" sboTerm="SBO:0000176" id="R_GLUTRS" name="Glutamyl-tRNA synthetase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_GLUTRS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/GLUTRS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/6.1.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/6.1.1.17"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/6.1.1.24"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R05578"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100295"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-379861"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-380216"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/5179"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn06937"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
@@ -2784,8 +24094,31 @@
           <speciesReference species="M_glutrna_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_GLXCL" name="R_GLXCL" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b2400"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_GLXCL" sboTerm="SBO:0000176" id="R_GLXCL" name="Glyoxalate carboligase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_GLXCL">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/GLXCL"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:GLYOCARBOLIG-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.1.1.47"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00013"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100303"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10138"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10139"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10137"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10136"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00010"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_glxBIO_c" stoichiometry="2" constant="true"/>
@@ -2794,8 +24127,34 @@
           <speciesReference species="M_2h3oppan_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_GLYCDx" name="R_GLYCDx" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0507"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_GLYCDx" sboTerm="SBO:0000176" id="R_GLYCDx" name="Glycerol dehydrogenase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_GLYCDx">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/GLYCDx"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:GLYCDEH-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.6"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01034"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100326"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13770"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13772"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13769"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13771"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/1322"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00762"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/24.091218069740307"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0011848386603530159"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_glyc_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
@@ -2805,8 +24164,46 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_GLYCK" name="R_GLYCK" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3945"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_GLYCK" sboTerm="SBO:0000176" id="R_GLYCK" name="Glycerate kinase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_GLYCK">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/GLYCK"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:GLY3KIN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.1.31"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01514"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100328"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-6799495"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-6799495"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-6799495"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-6799495"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-6799495"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-6799495"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-6799495"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-6799495"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-6799495"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-6799495"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-6799495"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-6799495"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23518"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23519"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23516"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23517"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/428"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01102"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-11.84812024939265"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.00037447974067987447"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_glyc__R_c" stoichiometry="1" constant="true"/>
@@ -2816,8 +24213,33 @@
           <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_GLYCL" name="R_GLYCL" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0514"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_GLYCL" sboTerm="SBO:0000176" id="R_GLYCL" name="Glycine Cleavage System" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_GLYCL">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/GLYCL"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.4.4.2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.8.1.4"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.1.2.10"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01221"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100330"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27760"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27759"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27761"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27758"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/19.04479327131716"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.5214073771031025"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_gly_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
@@ -2829,8 +24251,29 @@
           <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nh4_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_GLYCTO4" name="R_GLYCTO4" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:and>
+            <fbc:geneProductRef fbc:geneProduct="G_b2904"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2903"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2905"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0116"/>
+          </fbc:and>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_GLYCTO4" sboTerm="SBO:0000176" id="R_GLYCTO4" name="Glycolate oxidase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_GLYCTO4">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/GLYCTO4"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100341"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08657"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_2dmmq8_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_glyclt_c" stoichiometry="1" constant="true"/>
@@ -2839,24 +24282,241 @@
           <speciesReference species="M_2dmmql8_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_glxBIO_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_GLYCtex" name="R_GLYCtex" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:and>
+            <fbc:geneProductRef fbc:geneProduct="G_b2979"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b4467"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b4468"/>
+          </fbc:and>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_GLYCtex" sboTerm="SBO:0000185" id="R_GLYCtex" name="Glycerol transport via diffusion (extracellular to periplasm)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_GLYCtex">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/GLYCtex"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:TRANS-RXN-131"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100343"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-507871"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-507871"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-432049"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-507869"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-432049"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-507869"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-507869"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-432049"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-432049"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-507871"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-432074"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-432049"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-432049"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-432049"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-507871"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-507871"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-507871"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-507869"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-507869"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-507869"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-507869"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-507869"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-507869"/>
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@@ -2877,7 +24562,30 @@
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@@ -2891,8 +24599,52 @@
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+              <bqbiol:is>
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+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-71299"/>
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         <listOfReactants>
           <speciesReference species="M_6pgc_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
@@ -2902,8 +24654,52 @@
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           <speciesReference species="M_ru5p__D_c" stoichiometry="1" constant="true"/>
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-      </reaction>
-      <reaction id="R_GRTT" name="R_GRTT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b2029"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_GRTT" sboTerm="SBO:0000176" id="R_GRTT" name="Geranyltranstransferase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
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+              <bqbiol:is>
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+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-191303"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-191303"/>
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+          </rdf:RDF>
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         <listOfReactants>
           <speciesReference species="M_grdp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ipdp_c" stoichiometry="1" constant="true"/>
@@ -2912,8 +24708,25 @@
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           <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
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-      </reaction>
-      <reaction id="R_GRXR" name="R_GRXR" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0421"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_GRXR" sboTerm="SBO:0000176" id="R_GRXR" name="Glutaredoxin reductase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
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+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/GRXR"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08670"/>
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         <listOfReactants>
           <speciesReference species="M_grxox_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_gthrd_c" stoichiometry="2" constant="true"/>
@@ -2922,8 +24735,73 @@
           <speciesReference species="M_grxrd_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_gthox_c" stoichiometry="1" constant="true"/>
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-      <reaction id="R_GTHOr" name="R_GTHOr" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b1064"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b3610"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b1654"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0849"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_GTHOr" sboTerm="SBO:0000176" id="R_GTHOr" name="Glutathione oxidoreductase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
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+              <bqbiol:is>
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+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-3323079"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11740"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11743"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/695"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00086"/>
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+        </annotation>
         <listOfReactants>
           <speciesReference species="M_gthox_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
@@ -2933,8 +24811,50 @@
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           <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
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-      </reaction>
-      <reaction id="R_GTPCI" name="R_GTPCI" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3500"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_GTPCI" sboTerm="SBO:0000176" id="R_GTPCI" name="GTP cyclohydrolase I" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
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+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-1474146"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-1474146"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17476"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/9177"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00299"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn11232"/>
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         <listOfReactants>
           <speciesReference species="M_gtp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
@@ -2944,8 +24864,30 @@
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-      <reaction id="R_GTPCII2" name="R_GTPCII2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
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+              <bqbiol:is>
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@@ -2956,40 +24898,411 @@
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+            <fbc:geneProductRef fbc:geneProduct="G_b0875"/>
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+            <fbc:geneProductRef fbc:geneProduct="G_b2215"/>
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-      <reaction id="R_HACD1" name="R_HACD1" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_s0001"/>
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+        <annotation>
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+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-77312"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/30801"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/30802"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/2018"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01451"/>
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         <listOfReactants>
           <speciesReference species="M_aacoa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
@@ -2999,8 +25312,52 @@
           <speciesReference species="M_3hbcoa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
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-      </reaction>
-      <reaction id="R_HACD2" name="R_HACD2" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b3846"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2341"/>
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+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_HACD2" sboTerm="SBO:0000176" id="R_HACD2" name="3-hydroxyacyl-CoA dehydrogenase (3-oxohexanoyl-CoA)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
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+              <bqbiol:is>
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+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-77323"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-77323"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-77323"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-77323"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/4404"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn03249"/>
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+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_3ohcoa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
@@ -3010,8 +25367,51 @@
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           <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
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-      </reaction>
-      <reaction id="R_HACD3" name="R_HACD3" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b3846"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2341"/>
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+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_HACD3" sboTerm="SBO:0000176" id="R_HACD3" name="3-hydroxyacyl-CoA dehydrogenase (3-oxooctanoyl-CoA)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
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+            <rdf:Description rdf:about="#meta_R_HACD3">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/HACD3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.35"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100544"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-77331"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-77331"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-77331"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-77331"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-77331"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-77331"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-77331"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-77331"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-77331"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-77331"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-77331"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/31196"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/4401"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn03246"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-18.828103321380468"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.03257183377291173"/>
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+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_3oocoa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
@@ -3021,8 +25421,52 @@
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-      </reaction>
-      <reaction id="R_HACD4" name="R_HACD4" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b3846"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2341"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_HACD4" sboTerm="SBO:0000176" id="R_HACD4" name="3-hydroxyacyl-CoA dehydrogenase (3-oxodecanoyl-CoA)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
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+              <bqbiol:is>
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+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-77342"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-77342"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-77342"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/4399"/>
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+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_3odcoa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
@@ -3032,8 +25476,50 @@
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           <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
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-      </reaction>
-      <reaction id="R_HACD5" name="R_HACD5" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b3846"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2341"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_HACD5" sboTerm="SBO:0000176" id="R_HACD5" name="3-hydroxyacyl-CoA dehydrogenase (3-oxododecanoyl-CoA)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_HACD5">
+              <bqbiol:is>
+                <rdf:Bag>
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+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-77254"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-77254"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/rhea/31180"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn03242"/>
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+            </rdf:Description>
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+        </annotation>
         <listOfReactants>
           <speciesReference species="M_3oddcoa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
@@ -3043,8 +25529,49 @@
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           <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
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-      </reaction>
-      <reaction id="R_HACD6" name="R_HACD6" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b3846"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2341"/>
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+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_HACD6" sboTerm="SBO:0000176" id="R_HACD6" name="3-hydroxyacyl-CoA dehydrogenase (3-oxotetradecanoyl-CoA)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_HACD6">
+              <bqbiol:is>
+                <rdf:Bag>
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+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-77283"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-77283"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-77283"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-77283"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/rhea/31170"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/31168"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/4395"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn06777"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.03257183377291173"/>
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+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_3otdcoa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
@@ -3054,8 +25581,49 @@
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           <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
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-      </reaction>
-      <reaction id="R_HACD7" name="R_HACD7" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b3846"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2341"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_HACD7" sboTerm="SBO:0000176" id="R_HACD7" name="3-hydroxyacyl-CoA dehydrogenase (3-oxohexadecanoyl-CoA)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_HACD7">
+              <bqbiol:is>
+                <rdf:Bag>
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+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN-14271"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-77303"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-77303"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-77303"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-77303"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-77303"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/rhea/31162"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/4393"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn03239"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-18.828103321380922"/>
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+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_3ohdcoa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
@@ -3065,8 +25633,36 @@
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           <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_HBZOPT" name="R_HBZOPT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b3846"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2341"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_HBZOPT" sboTerm="SBO:0000176" id="R_HBZOPT" name="Hydroxybenzoate octaprenyltransferase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_HBZOPT">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/HBZOPT"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:4OHBENZOATE-OCTAPRENYLTRANSFER-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.5.1.39"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R05615"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100566"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27783"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27785"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27784"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27782"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn03893"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.01426424121585955"/>
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+            </rdf:Description>
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+        </annotation>
         <listOfReactants>
           <speciesReference species="M_4hbz_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_octdp_c" stoichiometry="1" constant="true"/>
@@ -3075,8 +25671,196 @@
           <speciesReference species="M_3ophb_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_HCO3E" name="R_HCO3E" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b4040"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_HCO3E" sboTerm="SBO:0000176" id="R_HCO3E" name="HCO3 equilibration reaction" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_HCO3E">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/HCO3E"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN0-5224"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:CARBODEHYDRAT-RXN"/>
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+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_hisp_c" stoichiometry="1" constant="true"/>
@@ -3118,8 +25985,53 @@
           <speciesReference species="M_histd_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_HMBS" name="R_HMBS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b2022"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_HMBS" sboTerm="SBO:0000176" id="R_HMBS" name="Hydroxymethylbilane synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_HMBS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/HMBS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:OHMETHYLBILANESYN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.5.1.61"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.3.1.8"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00084"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100658"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-421439"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-189406"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-189406"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-189406"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-189406"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-189406"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-189406"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-189406"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-189406"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-189406"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-189406"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-189406"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-189406"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-189406"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-189406"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-189406"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-189406"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-189406"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13187"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13186"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13185"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13188"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/669"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00060"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-133.09838484114937"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.6683245327062881"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ppbng_c" stoichiometry="4" constant="true"/>
@@ -3128,8 +26040,32 @@
           <speciesReference species="M_hmbil_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nh4_c" stoichiometry="4" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_HPPK2" name="R_HPPK2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3805"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_HPPK2" sboTerm="SBO:0000176" id="R_HPPK2" name="6-hydroxymethyl-dihydropterin pyrophosphokinase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_HPPK2">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/HPPK2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:H2PTERIDINEPYROPHOSPHOKIN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.6.3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R03503"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100694"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11413"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11412"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11415"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11414"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/0.35632186947725586"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.130022756787918"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_6hmhpt_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
@@ -3139,8 +26075,33 @@
           <speciesReference species="M_amp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_HSDy" name="R_HSDy" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0142"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_HSDy" sboTerm="SBO:0000176" id="R_HSDy" name="Homoserine dehydrogenase (NADPH)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_HSDy">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/HSDy"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01775"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100734"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15761"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15764"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15763"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15762"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/1868"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01302"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/22.09804051350079"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.0003132174311217817"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_hom__L_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
@@ -3150,8 +26111,37 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_HSK" name="R_HSK" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b3940"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0002"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_HSK" sboTerm="SBO:0000176" id="R_HSK" name="Homoserine kinase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_HSK">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/HSK"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:HOMOSERKIN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.1.39"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01771"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100737"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13985"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13987"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13986"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13988"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/1866"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01300"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-35.81480885800369"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.039194977350467286"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_hom__L_c" stoichiometry="1" constant="true"/>
@@ -3161,8 +26151,33 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_phom_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_HSST" name="R_HSST" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0003"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_HSST" sboTerm="SBO:0000176" id="R_HSST" name="Homoserine O-succinyltransferase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_HSST">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/HSST"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:HOMSUCTRAN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.1.46"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01777"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100741"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22010"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22011"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22009"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22008"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01304"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-28.157790680935932"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.07679397514837927"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_hom__L_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_succoa_c" stoichiometry="1" constant="true"/>
@@ -3171,8 +26186,34 @@
           <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_suchms_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_HSTPT" name="R_HSTPT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b4013"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_HSTPT" sboTerm="SBO:0000176" id="R_HSTPT" name="Histidinol-phosphate transaminase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_HSTPT">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/HSTPT"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:HISTAMINOTRANS-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.6.1.9"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R03243"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95852"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23747"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23745"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23744"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23746"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/3064"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn02320"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/9.477821353859838"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/7.993605777301127e-15"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_imacp_c" stoichiometry="1" constant="true"/>
@@ -3181,16 +26222,102 @@
           <speciesReference species="M_akg_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_hisp_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_Htex" name="R_Htex" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b2021"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_Htex" sboTerm="SBO:0000185" id="R_Htex" name="Proton transport via diffusion (extracellular to periplasm)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_Htex">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/Htex"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN-14452"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100765"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-2534378"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-74723"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-170026"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-170026"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-74723"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-74723"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-170026"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-2534378"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-74723"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-2534378"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-74723"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-170026"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-2534378"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-2534378"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-2534378"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-2534378"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-2534378"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-170026"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-170026"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-170026"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-170026"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-2534378"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-74723"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-74723"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-74723"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-74723"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-2534378"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-74723"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-74723"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-74723"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-170026"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-170026"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-74723"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-74723"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-74723"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-74723"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-170026"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-170026"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-74723"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-170026"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-170026"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-170026"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/34980"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/34981"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/34982"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/34979"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn11009"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08730"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-14.47275"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h_e" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_h_p" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_I2FE2SR" name="R_I2FE2SR" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b0929"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b1377"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2215"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0241"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_I2FE2SR" sboTerm="SBO:0000176" id="R_I2FE2SR" name="ISC [2Fe-2S] regeneration" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_I2FE2SR">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/I2FE2SR"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100766"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_2fe1s_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_iscssh_c" stoichiometry="1" constant="true"/>
@@ -3201,8 +26328,26 @@
           <speciesReference species="M_iscs_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_iscu__2fe2s_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_I2FE2SS" name="R_I2FE2SS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:and>
+            <fbc:geneProductRef fbc:geneProduct="G_b2530"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2529"/>
+          </fbc:and>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_I2FE2SS" sboTerm="SBO:0000176" id="R_I2FE2SS" name="ISC [2Fe-2S] Synthesis" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_I2FE2SS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/I2FE2SS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100767"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_fadh2_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_fe2_c" stoichiometry="2" constant="true"/>
@@ -3215,8 +26360,27 @@
           <speciesReference species="M_iscs_c" stoichiometry="2" constant="true"/>
           <speciesReference species="M_iscu__2fe2s_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_I2FE2SS2" name="R_I2FE2SS2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:and>
+            <fbc:geneProductRef fbc:geneProduct="G_b3807"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2530"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2529"/>
+          </fbc:and>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_I2FE2SS2" sboTerm="SBO:0000176" id="R_I2FE2SS2" name="ISC [2Fe-2S] Synthesis II" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_I2FE2SS2">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/I2FE2SS2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100768"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_fadh2_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_fe2_c" stoichiometry="2" constant="true"/>
@@ -3229,8 +26393,27 @@
           <speciesReference species="M_iscs_c" stoichiometry="2" constant="true"/>
           <speciesReference species="M_iscu__2fe2s2_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_I2FE2ST" name="R_I2FE2ST" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:and>
+            <fbc:geneProductRef fbc:geneProduct="G_b3807"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2530"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2529"/>
+          </fbc:and>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_I2FE2ST" sboTerm="SBO:0000176" id="R_I2FE2ST" name="ISC [2Fe-2S] Transfer" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_I2FE2ST">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/I2FE2ST"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100769"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h_c" stoichiometry="4" constant="true"/>
           <speciesReference species="M_iscu__2fe2s_c" stoichiometry="1" constant="true"/>
@@ -3239,8 +26422,26 @@
           <speciesReference species="M_2fe2s_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_iscu_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_I4FE4SR" name="R_I4FE4SR" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:and>
+            <fbc:geneProductRef fbc:geneProduct="G_b2528"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2529"/>
+          </fbc:and>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_I4FE4SR" sboTerm="SBO:0000176" id="R_I4FE4SR" name="ISC [4Fe-4S] Reduction" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_I4FE4SR">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/I4FE4SR"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100770"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_fadh2_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="2" constant="true"/>
@@ -3250,8 +26451,23 @@
           <speciesReference species="M_fad_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_iscu__4fe4s_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_I4FE4ST" name="R_I4FE4ST" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b2529"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_I4FE4ST" sboTerm="SBO:0000176" id="R_I4FE4ST" name="ISC [4Fe-4S] Transfer" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_I4FE4ST">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/I4FE4ST"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100771"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h_c" stoichiometry="4" constant="true"/>
           <speciesReference species="M_iscu__4fe4s_c" stoichiometry="1" constant="true"/>
@@ -3260,8 +26476,36 @@
           <speciesReference species="M_4fe4s_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_iscu_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ICDHyr" name="R_ICDHyr" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:and>
+            <fbc:geneProductRef fbc:geneProduct="G_b2528"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2529"/>
+          </fbc:and>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ICDHyr" sboTerm="SBO:0000176" id="R_ICDHyr" name="Isocitrate dehydrogenase (NADP)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ICDHyr">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ICDHyr"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.42"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00267"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100781"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/19629"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/19630"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/19631"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/19632"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/269"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00198"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/5.159640881575569"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0056356997190265545"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_icit_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
@@ -3271,8 +26515,33 @@
           <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ICL" name="R_ICL" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b1136"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ICL" sboTerm="SBO:0000176" id="R_ICL" name="Isocitrate lyase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ICL">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ICL"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.1.3.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00479"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100789"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13248"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13245"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13246"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13247"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/911"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00336"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/9.499576665503042"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-6.961473298013157e-05"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_icit_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
@@ -3280,8 +26549,23 @@
           <speciesReference species="M_glx_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_succ_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ICYSDS" name="R_ICYSDS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b4015"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ICYSDS" sboTerm="SBO:0000176" id="R_ICYSDS" name="ISC Cysteine desulfuration" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ICYSDS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ICYSDS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100790"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_cys__L_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_iscs_c" stoichiometry="1" constant="true"/>
@@ -3290,8 +26574,36 @@
           <speciesReference species="M_ala__L_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_iscssh_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_IG3PS" name="R_IG3PS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b2530"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_IG3PS" sboTerm="SBO:0000176" id="R_IG3PS" name="Imidazole-glycerol-3-phosphate synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_IG3PS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/IG3PS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:GLUTAMIDOTRANS-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.1.3.-"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.3.2.M2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.4.2.-"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R04558"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100811"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24796"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24794"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24793"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24795"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/4234"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn03135"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/238.29753447299169"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/2.080794859680966"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_gln__L_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_prlp_c" stoichiometry="1" constant="true"/>
@@ -3302,8 +26614,36 @@
           <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_IGPDH" name="R_IGPDH" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:and>
+            <fbc:geneProductRef fbc:geneProduct="G_b2023"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2025"/>
+          </fbc:and>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_IGPDH" sboTerm="SBO:0000176" id="R_IGPDH" name="Imidazoleglycerol-phosphate dehydratase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_IGPDH">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/IGPDH"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:IMIDPHOSDEHYD-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.2.1.19"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R03457"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100813"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11041"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11043"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11040"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11042"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn02473"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-42.512599889463615"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.027635578991253684"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_eig3p_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
@@ -3311,8 +26651,33 @@
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_imacp_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_IGPS" name="R_IGPS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b2022"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_IGPS" sboTerm="SBO:0000176" id="R_IGPS" name="Indole-3-glycerol-phosphate synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_IGPS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/IGPS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:IGPSYN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.1.1.48"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R03508"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100814"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23476"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23479"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23477"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23478"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn02507"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-75.35213754302684"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.3195781957631956"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_2cpr5p_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
@@ -3322,8 +26687,34 @@
           <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ILETA" name="R_ILETA" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b1262"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ILETA" sboTerm="SBO:0000176" id="R_ILETA" name="Isoleucine transaminase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ILETA">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ILETA"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:BRANCHED-CHAINAMINOTRANSFERILEU-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.6.1.42"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R02199"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR96228"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24803"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24802"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24804"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24801"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/9086"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01575"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-5.827871040351454"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.19079736626359273"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_akg_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ile__L_c" stoichiometry="1" constant="true"/>
@@ -3332,8 +26723,52 @@
           <speciesReference species="M_3mop_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_IMPC" name="R_IMPC" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3770"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_IMPC" sboTerm="SBO:0000176" id="R_IMPC" name="IMP cyclohydrolase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_IMPC">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/IMPC"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:IMPCYCLOHYDROLASE-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.1.2.3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.5.4.10"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01127"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100783"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-73797"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-73797"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-419253"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-73797"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-73797"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-73797"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-73797"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-73797"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-73797"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-73797"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-73797"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-73797"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-73797"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-73797"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-73797"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-73797"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-73797"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18446"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18445"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18447"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18448"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/123"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00832"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/19.613280339529524"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/1.217342410726727"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_imp_c" stoichiometry="1" constant="true"/>
@@ -3341,8 +26776,52 @@
         <listOfProducts>
           <speciesReference species="M_fprica_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_IMPD" name="R_IMPD" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b4006"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_IMPD" sboTerm="SBO:0000176" id="R_IMPD" name="IMP dehydrogenase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_IMPD">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/IMPD"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:IMP-DEHYDROG-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.205"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01130"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100830"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-73794"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-421222"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-73794"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-73794"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-73794"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-73794"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-73794"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-73794"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-73794"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-73794"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-73794"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-73794"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-73794"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-73794"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-73794"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-73794"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-73794"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-73794"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11711"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11710"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11708"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11709"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/128"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00834"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/19.78721359479931"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.9893135718676097"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_imp_c" stoichiometry="1" constant="true"/>
@@ -3353,16 +26832,78 @@
           <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_xmp_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_IPDDI" name="R_IPDDI" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b2508"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_IPDDI" sboTerm="SBO:0000176" id="R_IPDDI" name="Isopentenyl-diphosphate D-isomerase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_IPDDI">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/IPDDI"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:IPPISOM-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/5.3.3.2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01123"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100796"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-191382"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-191382"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-191382"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-191382"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-191382"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-191382"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-191382"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-191382"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-191382"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-191382"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-191382"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-191382"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-191382"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-191382"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-191382"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-191382"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-191382"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23286"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23287"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23285"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23284"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/1382"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00830"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-4.7712394200499375"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/1.5265566588595902e-14"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_ipdp_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_dmpp_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_IPDPS" name="R_IPDPS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b2889"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_IPDPS" sboTerm="SBO:0000176" id="R_IPDPS" name="1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase (ipdp)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_IPDPS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/IPDPS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.17.1.2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100874"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08756"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-61.14675164449068"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.07235704305749358"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2mb4p_c" stoichiometry="1" constant="true"/>
@@ -3373,8 +26914,33 @@
           <speciesReference species="M_ipdp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_IPMD" name="R_IPMD" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0029"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_IPMD" sboTerm="SBO:0000176" id="R_IPMD" name="3-isopropylmalate dehydrogenase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_IPMD">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/IPMD"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:3-ISOPROPYLMALDEHYDROG-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.85"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R04426"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100878"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10894"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10893"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10895"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10892"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn03062"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/18.848386010478634"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.03257183377291173"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_3c2hmp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
@@ -3384,8 +26950,34 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_IPPMIa" name="R_IPPMIa" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0073"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_IPPMIa" sboTerm="SBO:0000176" id="R_IPPMIa" name="3-isopropylmalate dehydratase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_IPPMIa">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/IPPMIa"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN-8991"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.2.1.33"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R04001"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100827"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10679"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10677"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10678"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10676"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/3736"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn02811"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-3.7135223072767047"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.062379112667803355"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_3c2hmp_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
@@ -3393,8 +26985,36 @@
           <speciesReference species="M_2ippm_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_IPPMIb" name="R_IPPMIb" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:and>
+            <fbc:geneProductRef fbc:geneProduct="G_b0071"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0072"/>
+          </fbc:and>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_IPPMIb" sboTerm="SBO:0000176" id="R_IPPMIb" name="2-isopropylmalate hydratase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_IPPMIb">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/IPPMIb"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:3-ISOPROPYLMALISOM-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.2.1.33"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R03968"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100826"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16293"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16295"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16296"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16294"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn02789"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-0.3749381610552973"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.03919830567511426"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_2ippm_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
@@ -3402,8 +27022,36 @@
         <listOfProducts>
           <speciesReference species="M_3c3hmp_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_IPPS" name="R_IPPS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:and>
+            <fbc:geneProductRef fbc:geneProduct="G_b0071"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0072"/>
+          </fbc:and>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_IPPS" sboTerm="SBO:0000176" id="R_IPPS" name="2-isopropylmalate synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_IPPS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/IPPS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:2-ISOPROPYLMALATESYN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.3.13"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01213"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100879"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21527"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21525"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21524"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21526"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00902"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-22.97888356900603"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.012520758385914266"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_3mob_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_accoa_c" stoichiometry="1" constant="true"/>
@@ -3414,8 +27062,30 @@
           <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_K2L4Aabcpp" name="R_K2L4Aabcpp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0074"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_K2L4Aabcpp" sboTerm="SBO:0000185" id="R_K2L4Aabcpp" name="KDO(2)-lipid IV A transport via ABC system (periplasm)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_K2L4Aabcpp">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/K2L4Aabcpp"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100899"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/35248#1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/35249#1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/35247#1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/35250#1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08760"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-116.06263163695853"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.3042778552992583"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
@@ -3427,8 +27097,23 @@
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_kdo2lipid4_p" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_K2L4Aabctex" name="R_K2L4Aabctex" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0914"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_K2L4Aabctex" sboTerm="SBO:0000185" id="R_K2L4Aabctex" name="KDO(2)-lipid IV A transport via ABC system (periplasm to extracellular)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_K2L4Aabctex">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/K2L4Aabctex"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100900"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
@@ -3440,8 +27125,39 @@
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_kdo2lipid4_e" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_KARA1" name="R_KARA1" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:and>
+            <fbc:geneProductRef fbc:geneProduct="G_b3200"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b3201"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b3199"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b4261"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b4262"/>
+          </fbc:and>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_KARA1" sboTerm="SBO:0000176" id="R_KARA1" name="Ketol-acid reductoisomerase (2,3-dihydroxy-3-methylbutanoate)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_KARA1">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/KARA1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:ACETOLACTREDUCTOISOM-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.86"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.383"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R04439"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97523"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22070"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22068"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22069"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22071"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/18.2467142522803"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.03163218147956348"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_23dhmb_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
@@ -3451,8 +27167,31 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_KARA2" name="R_KARA2" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3774"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_KARA2" sboTerm="SBO:0000176" id="R_KARA2" name="Ketol-acid reductoisomerase (2-Acetolactate)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_KARA2">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/KARA2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:ACETOOHBUTREDUCTOISOM-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.86"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100902"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13496"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13494"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13495"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13493"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-18.246829462876576"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.03163218147956348"/>
+                </rdf:Bag>
+              </bqbiol:is>
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@@ -3472,8 +27234,31 @@
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@@ -3482,8 +27267,33 @@
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@@ -3493,8 +27303,32 @@
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@@ -3503,16 +27337,332 @@
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+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:LIPIDADISACCHARIDESYNTH-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.4.1.182"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R04606"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101119"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22668"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22669"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22671"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22670"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn03159"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-24.246789913051828"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.07214538622567462"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_lipidX_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_u23ga_c" stoichiometry="1" constant="true"/>
@@ -3543,8 +27752,29 @@
           <speciesReference species="M_lipidAds_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_udp_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_MALCOAMT" name="R_MALCOAMT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0182"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_MALCOAMT" sboTerm="SBO:0000176" id="R_MALCOAMT" name="Malonyl-CoA methyltransferase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_MALCOAMT">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/MALCOAMT"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101337"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/34900"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/34899"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/34902"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/34901"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/55.909278900808886"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-1.100013008435301"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_amet_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_malcoa_c" stoichiometry="1" constant="true"/>
@@ -3553,8 +27783,33 @@
           <speciesReference species="M_ahcys_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_malcoame_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_MALS" name="R_MALS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0777"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_MALS" sboTerm="SBO:0000176" id="R_MALS" name="Malate synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_MALS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/MALS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:MALSYN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.3.9"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00472"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101347"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18181"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18182"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18184"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18183"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00330"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-35.165514725434036"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.00359250140508849"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_accoa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_glx_c" stoichiometry="1" constant="true"/>
@@ -3565,8 +27820,34 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_mal__L_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_MCOATA" name="R_MCOATA" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b4014"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2976"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_MCOATA" sboTerm="SBO:0000176" id="R_MCOATA" name="Malonyl-CoA-ACP transacylase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_MCOATA">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/MCOATA"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:MALONYL-COA-ACP-TRANSACYL-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.1.85"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.1.86"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.1.0"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.1.39"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.1.-"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01626"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101421"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn05465"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_ACP_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_malcoa_c" stoichiometry="1" constant="true"/>
@@ -3575,8 +27856,29 @@
           <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_malACP_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_MCTP1App" name="R_MCTP1App" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:and>
+            <fbc:geneProductRef fbc:geneProduct="G_b1094"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b1092"/>
+          </fbc:and>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_MCTP1App" sboTerm="SBO:0000176" id="R_MCTP1App" name="Murein crosslinking transpeptidase 1A:(A2pm-&gt;D-ala) (periplasm)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_MCTP1App">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/MCTP1App"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101426"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08887"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/269.7649939773619"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/14.222222443372313"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_murein5p5p_p" stoichiometry="1" constant="true"/>
         </listOfReactants>
@@ -3584,8 +27886,88 @@
           <speciesReference species="M_ala__D_p" stoichiometry="1" constant="true"/>
           <speciesReference species="M_murein5px4p_p" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_MDH" name="R_MDH" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b0084"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0635"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0149"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b3396"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_MDH" sboTerm="SBO:0000176" id="R_MDH" name="Malate dehydrogenase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_MDH">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/MDH"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:MALATE-DEH-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.37"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.299"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00342"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101439"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-70979"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-198508"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-70979"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-70979"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-71783"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-71783"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-198508"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-71783"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-198508"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-70979"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-198508"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-71783"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-71783"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-71783"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-198508"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-70979"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-71783"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-198508"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-372422"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-71783"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-70979"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-198508"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-70979"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-71783"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-71783"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-198508"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-70979"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-70979"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-198508"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-71783"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-70979"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-71783"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-198508"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-372855"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-70979"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-70979"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-373047"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-198508"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-71783"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-70979"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-70979"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-71783"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-198508"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-198508"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-71783"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-70979"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-71783"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-70979"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21432"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21433"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21434"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21435"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/113"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00248"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/29.60588767370315"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.00011604275815814587"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_mal__L_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
@@ -3595,8 +27977,35 @@
           <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_oaa_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ME1" name="R_ME1" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3236"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ME1" sboTerm="SBO:0000176" id="R_ME1" name="Malic enzyme (NAD)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ME1">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ME1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:1.1.1.39-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.38"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.39"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00214"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101446"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12655"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12654"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12653"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12656"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/141"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00159"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/12.13403837061567"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0040888374851758644"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_mal__L_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
@@ -3606,8 +28015,34 @@
           <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ME2" name="R_ME2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b1479"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ME2" sboTerm="SBO:0000176" id="R_ME2" name="Malic enzyme (NADP)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ME2">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ME2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:MALIC-NADP-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.40"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00216"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101443"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18255"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18256"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18254"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18253"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/142"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00161"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/11.553331838611555"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0031491851918278384"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_mal__L_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
@@ -3617,8 +28052,23 @@
           <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_MECDPDH5" name="R_MECDPDH5" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b2463"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_MECDPDH5" sboTerm="SBO:0000176" id="R_MECDPDH5" name="2C-methyl-D-erythritol 2,4 cyclodiphosphate dehydratase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_MECDPDH5">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/MECDPDH5"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101450"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_2mecdp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_flxr_c" stoichiometry="2" constant="true"/>
@@ -3629,8 +28079,42 @@
           <speciesReference species="M_h2mb4p_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_MECDPS" name="R_MECDPS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b2895"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2515"/>
+            </fbc:and>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b0684"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2515"/>
+            </fbc:and>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_MECDPS" sboTerm="SBO:0000176" id="R_MECDPS" name="2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_MECDPS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/MECDPS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN0-302"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.6.1.12"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R05637"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101424"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23864"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23867"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23866"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23865"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn03910"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/1809.555671180957"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-2.644533211522508"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_2p4c2me_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
@@ -3638,24 +28122,101 @@
           <speciesReference species="M_2mecdp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_cmp_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_MEOHtex" name="R_MEOHtex" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b2746"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_MEOHtex" sboTerm="SBO:0000185" id="R_MEOHtex" name="Methanol transport via diffusion (extracellular to periplasm)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_MEOHtex">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/MEOHtex"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:TRANS-RXN0-459"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101464"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/34873"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/34872"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/34874"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/34871"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn10570"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/0.0"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_meoh_e" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_meoh_p" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_MEOHtrpp" name="R_MEOHtrpp" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b1377"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0929"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2215"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0241"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_MEOHtrpp" sboTerm="SBO:0000185" id="R_MEOHtrpp" name="Methanol reversible transport via diffusion (periplasm)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_MEOHtrpp">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/MEOHtrpp"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:TRANS-RXN0-459"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101464"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/34873"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/34872"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/34874"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/34871"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn10570"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-4.796163466380676e-14"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_meoh_p" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_meoh_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_MEPCT" name="R_MEPCT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_s0001"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_MEPCT" sboTerm="SBO:0000176" id="R_MEPCT" name="2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_MEPCT">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/MEPCT"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:2.7.7.60-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.7.60"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R05633"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR96807"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13430"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13429"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13432"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13431"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/5231"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn03907"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-9.818196910291633"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.06566694906810318"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_2me4p_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ctp_c" stoichiometry="1" constant="true"/>
@@ -3665,8 +28226,63 @@
           <speciesReference species="M_4c2me_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_METAT" name="R_METAT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b2747"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_METAT" sboTerm="SBO:0000176" id="R_METAT" name="Methionine adenosyltransferase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_METAT">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/METAT"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:S-ADENMETSYN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.5.1.6"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00177"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101407"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-174391"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-174391"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-174391"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-174391"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-5603114"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-174391"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-174391"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-174391"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-5603114"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-5603114"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-5603114"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-174391"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-174391"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-174391"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-174391"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-174391"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-174391"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-5603114"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-5603114"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-5603114"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-174391"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-5603114"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-174391"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-5603114"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-174391"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-5603114"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-5603114"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-174391"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-174391"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21082"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21081"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21080"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21083"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/96"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00126"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-89.25760129649528"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/1.283362018698307"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
@@ -3677,8 +28293,32 @@
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_METS" name="R_METS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b2942"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_METS" sboTerm="SBO:0000176" id="R_METS" name="Methionine synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_METS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/METS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.1.1.13"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00946"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101481"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11173"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11175"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11174"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11172"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/1260"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-1.8093657446670477"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.691168938943024"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_5mthf_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_hcys__L_c" stoichiometry="1" constant="true"/>
@@ -3688,8 +28328,29 @@
           <speciesReference species="M_met__L_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_thf_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_MG2t3_2pp" name="R_MG2t3_2pp" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b4019"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b3829"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_MG2t3_2pp" sboTerm="SBO:0000185" id="R_MG2t3_2pp" name="Magnesium (Mg+2) transport in/out via proton antiport (periplasm)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_MG2t3_2pp">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/MG2t3_2pp"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101508"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08921"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/5.704945844907011"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h_c" stoichiometry="2" constant="true"/>
           <speciesReference species="M_mg2_p" stoichiometry="1" constant="true"/>
@@ -3699,15 +28360,138 @@
           <speciesReference species="M_h_p" stoichiometry="2" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction id="R_MG2tex" name="R_MG2tex" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+      <reaction metaid="meta_R_MG2tex" sboTerm="SBO:0000185" id="R_MG2tex" name="Magnesium (Mg+2) transport via diffusion (extracellular to periplasm)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_MG2tex">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/MG2tex"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:TRANS-RXN-141"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101507"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-442661"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-5336466"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-5336453"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-442661"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-5336453"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-5339528"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-5336466"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-5339538"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-5336466"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-5339538"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-5336466"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-442661"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-5336453"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-5336466"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-5339538"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-5339538"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-5339528"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-5339528"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-5339538"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-5336453"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-5336453"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-5336453"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-5339528"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-5336466"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-5336453"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-5339528"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-5339538"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-5336466"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-5339528"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-5339528"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-5339528"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-5339528"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-442661"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-5339538"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-442661"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-5339538"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-5339538"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-5339538"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-442661"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-5336453"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-5336466"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-5339528"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-442661"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-5336453"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-5336466"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-5336466"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-442661"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-5336453"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-5339538"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-5336454"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-5339528"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-5339528"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-5339538"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-5339528"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-5336453"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-5336466"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-5336466"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-442661"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-5336466"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-5336453"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-5339538"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-442661"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-5336466"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-442661"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-5339538"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-5336430"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-442661"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-5336466"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-5339528"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29827"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29828"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29829"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29830"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/12062"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn05616"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08922"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08923"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-28.9455"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_mg2_e" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_mg2_p" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_MGSA" name="R_MGSA" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b0241"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0929"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b1377"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2215"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_MGSA" sboTerm="SBO:0000176" id="R_MGSA" name="Methylglyoxal synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_MGSA">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/MGSA"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:METHGLYSYN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.2.3.3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01016"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101551"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17939"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17938"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17937"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17940"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/176"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00748"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-60.40627322660353"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.09544742984097275"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_dhap_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
@@ -3715,24 +28499,94 @@
           <speciesReference species="M_mthgxl_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_MN2tpp" name="R_MN2tpp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0963"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_MN2tpp" sboTerm="SBO:0000185" id="R_MN2tpp" name="Manganese transport in via permease (no H+)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_MN2tpp">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/MN2tpp"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN0-16"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:TRANS-RXN0-487"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101670"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28702"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28699"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28700"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28701"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08952"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08947"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-28.379930135339706"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_mn2_p" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_mn2_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_MNtex" name="R_MNtex" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3040"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_MNtex" sboTerm="SBO:0000185" id="R_MNtex" name="Manganese (Mn+2) transport via diffusion (extracellular to periplasm)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_MNtex">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/MNtex"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN0-16"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:TRANS-RXN0-487"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101670"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28702"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28699"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28700"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28701"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08952"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08947"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-28.9455"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_mn2_e" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_mn2_p" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_MOADSUx" name="R_MOADSUx" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b0241"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0929"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b1377"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2215"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_MOADSUx" sboTerm="SBO:0000176" id="R_MOADSUx" name="MoaD sulfuration (nadh, assumed)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_MOADSUx">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/MOADSUx"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101682"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_iscssh_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_moadamp_c" stoichiometry="1" constant="true"/>
@@ -3744,8 +28598,36 @@
           <speciesReference species="M_moadcosh_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_MOAT" name="R_MOAT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:and>
+            <fbc:geneProductRef fbc:geneProduct="G_b2530"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0784"/>
+          </fbc:and>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_MOAT" sboTerm="SBO:0000176" id="R_MOAT" name="3-deoxy-D-manno-octulosonic acid transferase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_MOAT">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/MOAT"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:KDOTRANS-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.4.99.12"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R04658"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101683"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28067"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28068"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28066"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28069"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn03182"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-259.6903696189138"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.35605918994549013"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_ckdo_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_lipidA_c" stoichiometry="1" constant="true"/>
@@ -3755,8 +28637,34 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_kdolipid4_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_MOAT2" name="R_MOAT2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3633"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_MOAT2" sboTerm="SBO:0000176" id="R_MOAT2" name="3-deoxy-D-manno-octulosonic acid transferase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_MOAT2">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/MOAT2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:KDOTRANS2-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.4.99.13"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R05074"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R06285"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101684"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28063"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28062"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28065"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28064"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn03439"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-252.08829989519563"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.431896100171127"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_ckdo_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_kdolipid4_c" stoichiometry="1" constant="true"/>
@@ -3766,8 +28674,34 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_kdo2lipid4_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_MOBDabcpp" name="R_MOBDabcpp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3633"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_MOBDabcpp" sboTerm="SBO:0000185" id="R_MOBDabcpp" name="Molybdate transport via ABC system (periplasm)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_MOBDabcpp">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/MOBDabcpp"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:3.6.3.29-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:ABC-19-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.29"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101689"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22020#1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22023#1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22021#1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22022#1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn05619"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08955"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-29.218617912453276"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.30427719268021314"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
@@ -3779,16 +28713,76 @@
           <speciesReference species="M_mobd_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_MOBDtex" name="R_MOBDtex" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b0763"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b0764"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b0765"/>
+            </fbc:and>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b2422"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2424"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2423"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b3917"/>
+            </fbc:and>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b2422"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2425"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2424"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2423"/>
+            </fbc:and>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_MOBDtex" sboTerm="SBO:0000185" id="R_MOBDtex" name="Molybdate transport via diffusion (extracellular to periplasm)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_MOBDtex">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/MOBDtex"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101690"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/34909"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/34907"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/34910"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/34908"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08956"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/0.0"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_mobd_e" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_mobd_p" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_MOCOS" name="R_MOCOS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b0241"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0929"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b1377"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2215"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_MOCOS" sboTerm="SBO:0000176" id="R_MOCOS" name="Molybdenum cofactor synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_MOCOS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/MOCOS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR138626"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h_c" stoichiometry="2" constant="true"/>
           <speciesReference species="M_mobd_c" stoichiometry="1" constant="true"/>
@@ -3800,8 +28794,31 @@
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_moco_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_MOHMT" name="R_MOHMT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0827"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_MOHMT" sboTerm="SBO:0000176" id="R_MOHMT" name="3-methyl-2-oxobutanoate hydroxymethyltransferase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_MOHMT">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/MOHMT"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.1.2.11"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01226"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101702"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11824"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11827"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11825"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11826"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/9.630320159778535"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.5159268562332349"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_3mob_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
@@ -3811,8 +28828,32 @@
           <speciesReference species="M_2dhp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_thf_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_MPTAT" name="R_MPTAT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0134"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_MPTAT" sboTerm="SBO:0000176" id="R_MPTAT" name="Molybdopterin adenylyltransferase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_MPTAT">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/MPTAT"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN-8344"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.7.75"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R09726"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101730"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/31333"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/31334"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/31332"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/31331"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/842.9341370059104"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.005653967729050085"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
@@ -3822,8 +28863,23 @@
           <speciesReference species="M_mptamp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_MPTG" name="R_MPTG" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0009"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_MPTG" sboTerm="SBO:0000185" id="R_MPTG" name="Murein polymerizing transglycosylase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_MPTG">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/MPTG"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR143249"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_uaagmda_c" stoichiometry="2" constant="true"/>
         </listOfReactants>
@@ -3832,8 +28888,36 @@
           <speciesReference species="M_udcpdp_c" stoichiometry="2" constant="true"/>
           <speciesReference species="M_murein5p5p_p" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_MPTS" name="R_MPTS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b3396"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b1069"/>
+            </fbc:and>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b0149"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b1069"/>
+            </fbc:and>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b1069"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2519"/>
+            </fbc:and>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_MPTS" sboTerm="SBO:0000176" id="R_MPTS" name="Molybdopterin synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_MPTS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/MPTS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR143253"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_cpmp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_cu2_c" stoichiometry="1" constant="true"/>
@@ -3844,8 +28928,26 @@
           <speciesReference species="M_moadcoo_c" stoichiometry="2" constant="true"/>
           <speciesReference species="M_mpt_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_MPTSS" name="R_MPTSS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:and>
+            <fbc:geneProductRef fbc:geneProduct="G_b0784"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0785"/>
+          </fbc:and>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_MPTSS" sboTerm="SBO:0000176" id="R_MPTSS" name="Molybdopterin synthase sulfurylase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_MPTSS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/MPTSS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101736"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
@@ -3855,8 +28957,49 @@
           <speciesReference species="M_moadamp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_MTHFC" name="R_MTHFC" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0826"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_MTHFC" sboTerm="SBO:0000176" id="R_MTHFC" name="Methenyltetrahydrofolate cyclohydrolase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_MTHFC">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/MTHFC"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.5.4.9"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.5.1.15"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01655"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101748"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-6801462"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-6801462"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-6801462"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-6801462"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-6801462"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-6801462"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-6801462"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-6801462"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-6801462"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-6801462"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-6801462"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-6801462"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-6801462"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-6801462"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-6801462"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23701"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23700"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23702"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23703"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/74"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01211"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-3.699438360859176"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.00033513831733777977"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_methf_c" stoichiometry="1" constant="true"/>
@@ -3865,8 +29008,31 @@
           <speciesReference species="M_10fthf_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_MTHFD" name="R_MTHFD" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0529"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_MTHFD" sboTerm="SBO:0000176" id="R_MTHFD" name="Methylenetetrahydrofolate dehydrogenase (NADP)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_MTHFD">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/MTHFD"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.5.1.5"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01220"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101749"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22814"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22813"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22815"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22812"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/7.586735088067144"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.00018629269519143676"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_mlthf_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
@@ -3875,8 +29041,31 @@
           <speciesReference species="M_methf_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_MTHFR2" name="R_MTHFR2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0529"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_MTHFR2" sboTerm="SBO:0000176" id="R_MTHFR2" name="5,10-methylenetetrahydrofolate reductase (NADH)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_MTHFR2">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/MTHFR2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.5.1.20"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R07168"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101751"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/19822"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/19823"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/19821"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/19824"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-43.67740714049296"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.00904504336578893"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h_c" stoichiometry="2" constant="true"/>
           <speciesReference species="M_mlthf_c" stoichiometry="1" constant="true"/>
@@ -3886,8 +29075,30 @@
           <speciesReference species="M_5mthf_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_MTHTHFSs" name="R_MTHTHFSs" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3941"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_MTHTHFSs" sboTerm="SBO:0000176" id="R_MTHTHFSs" name="(2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran synthesis (spontaneous)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_MTHTHFSs">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/MTHTHFSs"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN-10017"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101756"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/35161"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/35162"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/35159"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/35160"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/826.2340397104589"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.2777097514703462"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_mdhdhf_c" stoichiometry="1" constant="true"/>
@@ -3895,8 +29106,27 @@
         <listOfProducts>
           <speciesReference species="M_mththf_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_NADH16pp" name="R_NADH16pp" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_s0001"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_NADH16pp" sboTerm="SBO:0000185" id="R_NADH16pp" name="NADH dehydrogenase (ubiquinone-8 &amp; 3 protons) (periplasm)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_NADH16pp">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/NADH16pp"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.6.5.3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101864"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08972"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-79.95394219095436"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/6.211579665462097"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h_c" stoichiometry="4" constant="true"/>
           <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
@@ -3907,8 +29137,41 @@
           <speciesReference species="M_q8h2_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_p" stoichiometry="3" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_NADH17pp" name="R_NADH17pp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:and>
+            <fbc:geneProductRef fbc:geneProduct="G_b2276"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2277"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2278"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2279"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2280"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2281"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2282"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2283"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2284"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2285"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2286"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2287"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2288"/>
+          </fbc:and>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_NADH17pp" sboTerm="SBO:0000185" id="R_NADH17pp" name="NADH dehydrogenase (menaquinone-8 &amp; 3 protons) (periplasm)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_NADH17pp">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/NADH17pp"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.6.5.3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101865"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08973"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/27.946891798261504"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/4.874554708979394"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h_c" stoichiometry="4" constant="true"/>
           <speciesReference species="M_mqn8_c" stoichiometry="1" constant="true"/>
@@ -3919,8 +29182,63 @@
           <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_p" stoichiometry="3" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_NADK" name="R_NADK" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:and>
+            <fbc:geneProductRef fbc:geneProduct="G_b2276"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2277"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2278"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2279"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2280"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2281"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2282"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2283"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2284"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2285"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2286"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2287"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2288"/>
+          </fbc:and>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_NADK" sboTerm="SBO:0000176" id="R_NADK" name="NAD kinase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_NADK">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/NADK"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:NAD-KIN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.1.23"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00104"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101882"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-197198"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-197198"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-197198"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-197198"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-197198"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-197198"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-197198"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-197198"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-197198"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-197198"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-197198"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-197198"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-197198"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-197198"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-197198"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18631"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18632"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18629"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18630"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/47"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00077"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-8.948232528679114"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/2.7533531010703882e-14"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
@@ -3930,8 +29248,35 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_NADS1" name="R_NADS1" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b2615"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_NADS1" sboTerm="SBO:0000176" id="R_NADS1" name="NAD synthase (nh3)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_NADS1">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/NADS1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:NAD-SYNTH-NH3-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/6.3.5.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/6.3.1.5"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00189"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101897"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21188"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21190"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21191"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21189"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/13688"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00138"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-19.072588451410112"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.13981812000602534"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_dnad_c" stoichiometry="1" constant="true"/>
@@ -3943,8 +29288,35 @@
           <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_NADTRHD" name="R_NADTRHD" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b1740"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_NADTRHD" sboTerm="SBO:0000176" id="R_NADTRHD" name="NAD transhydrogenase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_NADTRHD">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/NADTRHD"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:PYRNUTRANSHYDROGEN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.6.1.3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.6.1.2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.6.1.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00112"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101898"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11692"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11695"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11694"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11693"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00083"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/0.580706532004001"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0009396522933482476"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
@@ -3953,8 +29325,40 @@
           <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_NDPK1" name="R_NDPK1" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b3962"/>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b1602"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b1603"/>
+            </fbc:and>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_NDPK1" sboTerm="SBO:0000176" id="R_NDPK1" name="Nucleoside-diphosphate kinase (ATP:GDP)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_NDPK1">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/NDPK1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:GDPKIN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.4.6"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00330"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR96119"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27689"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27686"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27688"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27687"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/138"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00237"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-2.031539157676548"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.00028897960919582744"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_gdp_c" stoichiometry="1" constant="true"/>
@@ -3963,8 +29367,37 @@
           <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_gtp_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_NDPK2" name="R_NDPK2" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b0474"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2518"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_NDPK2" sboTerm="SBO:0000176" id="R_NDPK2" name="Nucleoside-diphosphate kinase (ATP:UDP)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_NDPK2">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/NDPK2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:UDPKIN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.4.6"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00156"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101935"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/25101"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/25098"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/25100"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/25099"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/199"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00117"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/2.109075570462096"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.00035632237830651725"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_udp_c" stoichiometry="1" constant="true"/>
@@ -3973,8 +29406,36 @@
           <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_utp_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_NDPK3" name="R_NDPK3" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b0474"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2518"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_NDPK3" sboTerm="SBO:0000176" id="R_NDPK3" name="Nucleoside-diphosphate kinase (ATP:CDP)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_NDPK3">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/NDPK3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:CDPKIN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.4.6"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00570"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101936"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/25240"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/25239"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/25237"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/25238"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00409"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/0.3169452534795596"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.1176594194983297"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_cdp_c" stoichiometry="1" constant="true"/>
@@ -3983,8 +29444,37 @@
           <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ctp_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_NDPK4" name="R_NDPK4" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b2518"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0474"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_NDPK4" sboTerm="SBO:0000176" id="R_NDPK4" name="Nucleoside-diphosphate kinase (ATP:dTDP)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_NDPK4">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/NDPK4"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:DTDPKIN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.4.6"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R02093"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101937"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27682"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27684"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27683"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27685"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/423"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01512"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/0.9501107158463356"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.15006267245714644"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_dtdp_c" stoichiometry="1" constant="true"/>
@@ -3993,8 +29483,36 @@
           <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_dttp_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_NDPK8" name="R_NDPK8" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b0474"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2518"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_NDPK8" sboTerm="SBO:0000176" id="R_NDPK8" name="Nucleoside-diphosphate kinase (ATP:dADP)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_NDPK8">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/NDPK8"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:DADPKIN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.4.6"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01137"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101940"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27675"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27674"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27677"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27676"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00839"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/2.5485245409654453"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.08542813264684662"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_dadp_c" stoichiometry="1" constant="true"/>
@@ -4003,40 +29521,262 @@
           <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_datp_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_NH4tex" name="R_NH4tex" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b0474"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2518"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_NH4tex" sboTerm="SBO:0000185" id="R_NH4tex" name="Ammonia transport via diffusion (extracellular to periplasm)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_NH4tex">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/NH4tex"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:TRANS-RXN0-206"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN-9615"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:TRANS-RXN0-544"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101950"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-444416"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-444416"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-444416"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-444416"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-444416"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-444416"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-444416"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-444416"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-444416"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-444416"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-444416"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-444416"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-444416"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28749"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28748"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28750"/>
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+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_nh4_e" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_nh4_p" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_NH4tpp" name="R_NH4tpp" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b0241"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0929"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b1377"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2215"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_NH4tpp" sboTerm="SBO:0000185" id="R_NH4tpp" name="Ammonia reversible transport (periplasm)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
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+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08986"/>
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+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_nh4_p" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_nh4_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_NI2tex" name="R_NI2tex" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b0451"/>
+            <fbc:geneProductRef fbc:geneProduct="G_s0001"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_NI2tex" sboTerm="SBO:0000185" id="R_NI2tex" name="Nickel transport via diffusion (extracellular to periplasm)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_NI2tex">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/NI2tex"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:TRANS-RXN-141B"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101958"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29833"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29834"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29832"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-28.9455"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_ni2_e" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_ni2_p" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_NI2tpp" name="R_NI2tpp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b0241"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0929"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b1377"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2215"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_NI2tpp" sboTerm="SBO:0000185" id="R_NI2tpp" name="Nickel (+2) transport in via permease (no H+)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_NI2tpp">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/NI2tpp"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:TRANS-RXN-141B"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101958"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29833"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29831"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29834"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29832"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-28.379930135339706"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_ni2_p" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_ni2_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_NNATr" name="R_NNATr" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3816"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_NNATr" sboTerm="SBO:0000176" id="R_NNATr" name="Nicotinate-nucleotide adenylyltransferase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_NNATr">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/NNATr"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:NICONUCADENYLYLTRAN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.7.18"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.7.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R03005"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101978"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-197235"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-200474"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-200512"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-197235"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-200512"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-197235"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-200512"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-200474"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-197235"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-197235"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-197235"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-197235"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-200512"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-200512"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-197235"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-197235"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-200512"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-200512"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-200474"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-200512"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-200512"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-200512"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-200474"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-200474"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-197235"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-200512"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-197235"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-200474"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-200512"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-197235"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-200474"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-200474"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-197235"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-200512"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-200474"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-200474"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-197235"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-200474"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-200512"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-197235"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-200512"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-200474"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-200474"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-200474"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-200474"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-197235"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-200512"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22863"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22861"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22862"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22860"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/2857"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn02155"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-25.148359133004575"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.1287563906054059"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
@@ -4046,8 +29786,46 @@
           <speciesReference species="M_dnad_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_NNDPR" name="R_NNDPR" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0639"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_NNDPR" sboTerm="SBO:0000176" id="R_NNDPR" name="Nicotinate-nucleotide diphosphorylase (carboxylating)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_NNDPR">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/NNDPR"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:QUINOPRIBOTRANS-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.4.2.19"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R03348"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101980"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-197268"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-197268"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-197268"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-197268"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-197268"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-197268"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-197268"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-197268"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-197268"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-197268"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-197268"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-197268"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12735"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12733"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12734"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12736"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/3155"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn02402"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-30.421484443518736"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.07129582800792901"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h_c" stoichiometry="2" constant="true"/>
           <speciesReference species="M_prpp_c" stoichiometry="1" constant="true"/>
@@ -4058,8 +29836,34 @@
           <speciesReference species="M_nicrnt_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_NTD2" name="R_NTD2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0109"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_NTD2" sboTerm="SBO:0000176" id="R_NTD2" name="5&apos;-nucleotidase (UMP)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_NTD2">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/NTD2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN-14025"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.1.3.5"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00963"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102032"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29362"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29360"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29361"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29359"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/210"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00708"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-9.771441459601135"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.2261100950789195"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ump_c" stoichiometry="1" constant="true"/>
@@ -4068,8 +29872,37 @@
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_uri_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_NTD6" name="R_NTD6" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b2744"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b4374"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_NTD6" sboTerm="SBO:0000176" id="R_NTD6" name="5&apos;-nucleotidase (dAMP)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_NTD6">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/NTD6"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN-14161"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.1.3.5"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.1.3.89"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R02088"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102036"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29371"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29374"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29372"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29373"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/282"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn13134"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01507"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_damp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
@@ -4078,24 +29911,120 @@
           <speciesReference species="M_dad__2_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_O2tex" name="R_O2tex" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b2291"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2744"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_O2tex" sboTerm="SBO:0000185" id="R_O2tex" name="Oxygen transport via diffusion (extracellular to periplasm)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_O2tex">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/O2tex"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:TRANS-RXN0-474"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102090"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09641"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn05468"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09031"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09032"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09734"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/0.0"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_o2_e" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_o2_p" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_O2tpp" name="R_O2tpp" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b0241"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0929"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b1377"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2215"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_O2tpp" sboTerm="SBO:0000185" id="R_O2tpp" name="O2 transport via diffusion (periplasm)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_O2tpp">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/O2tpp"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:TRANS-RXN0-474"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102090"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09641"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn05468"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09031"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09032"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09734"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/0.0"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_o2_p" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_o2_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_OCBT" name="R_OCBT" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_s0001"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_OCBT" sboTerm="SBO:0000176" id="R_OCBT" name="Ornithine carbamoyltransferase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_OCBT">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/OCBT"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN-13482"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:ORNCARBAMTRANSFER-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.1.3.3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01398"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102137"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-70560"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-70560"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-70560"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-70560"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-70560"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-70560"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-70560"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-70560"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-70560"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-70560"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-70560"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-70560"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-70560"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-187588"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-70560"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/19514"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/19516"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/19513"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/19515"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/98"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01019"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-30.614701806453184"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/1.2176024077881209e-14"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_cbp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_orn_c" stoichiometry="1" constant="true"/>
@@ -4105,8 +30034,36 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_OCTDPS" name="R_OCTDPS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b4254"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0273"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_OCTDPS" sboTerm="SBO:0000176" id="R_OCTDPS" name="Octaprenyl pyrophosphate synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_OCTDPS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/OCTDPS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN-8992"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.5.1.90"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R09248"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102153"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27801"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27799"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27800"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27798"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09037"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-403.7078626505453"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.9273435695365523"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_frdp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ipdp_c" stoichiometry="5" constant="true"/>
@@ -4115,8 +30072,26 @@
           <speciesReference species="M_octdp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ppi_c" stoichiometry="5" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_OGMEACPD" name="R_OGMEACPD" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3187"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_OGMEACPD" sboTerm="SBO:0000176" id="R_OGMEACPD" name="3-Oxo-glutaryl-[ACP] methyl ester dehydratase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_OGMEACPD">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/OGMEACPD"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN-11477"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.2.1.59"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R10117"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102159"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_hgmeACP_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
@@ -4124,8 +30099,23 @@
           <speciesReference species="M_egmeACP_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_OGMEACPR" name="R_OGMEACPR" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0180"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_OGMEACPR" sboTerm="SBO:0000176" id="R_OGMEACPR" name="3-Oxo-glutaryl-[ACP] methyl ester reductase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_OGMEACPR">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/OGMEACPR"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102160"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
@@ -4135,8 +30125,23 @@
           <speciesReference species="M_hgmeACP_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_OGMEACPS" name="R_OGMEACPS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b1093"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_OGMEACPS" sboTerm="SBO:0000176" id="R_OGMEACPS" name="3-Oxo-glutaryl-[ACP] methyl ester synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_OGMEACPS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/OGMEACPS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102161"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_malACP_c" stoichiometry="1" constant="true"/>
@@ -4147,8 +30152,33 @@
           <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ogmeACP_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_OHPBAT" name="R_OHPBAT" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b1091"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_OHPBAT" sboTerm="SBO:0000176" id="R_OHPBAT" name="O-Phospho-4-hydroxy-L-threonine:2-oxoglutarate aminotransferase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_OHPBAT">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/OHPBAT"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:PSERTRANSAMPYR-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.6.1.52"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R05085"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102169"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16576"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16575"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16574"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16573"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn03445"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/10.674403343729864"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.022941698635197558"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ohpb_c" stoichiometry="1" constant="true"/>
@@ -4157,8 +30187,33 @@
           <speciesReference species="M_akg_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_phthr_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_OMCDC" name="R_OMCDC" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0907"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_OMCDC" sboTerm="SBO:0000176" id="R_OMCDC" name="2-Oxo-4-methyl-3-carboxypentanoate decarboxylation" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_OMCDC">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/OMCDC"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN-7800"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.85"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01652"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102180"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/25078"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/25080"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/25081"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/25079"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01208"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-16.81194209283899"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.11974543117266621"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_3c4mop_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
@@ -4167,8 +30222,53 @@
           <speciesReference species="M_4mop_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_OMPDC" name="R_OMPDC" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_s0001"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_OMPDC" sboTerm="SBO:0000176" id="R_OMPDC" name="Orotidine-5&apos;-phosphate decarboxylase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_OMPDC">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/OMPDC"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:OROTPDECARB-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.1.1.23"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00965"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102190"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-73564"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-419461"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-73564"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-73564"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-73564"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-73564"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-73564"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-73564"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-73564"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-73564"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-73564"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-73564"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-73564"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-73564"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-73564"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-73564"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-73564"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-73564"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-73564"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11597"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11599"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11596"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11598"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/463"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00710"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-26.031337861454517"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.23430682616702625"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_orot5p_c" stoichiometry="1" constant="true"/>
@@ -4177,8 +30277,33 @@
           <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ump_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_OPHBDC" name="R_OPHBDC" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b1281"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_OPHBDC" sboTerm="SBO:0000176" id="R_OPHBDC" name="Octaprenyl-hydroxybenzoate decarboxylase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_OPHBDC">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/OPHBDC"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:3-OCTAPRENYL-4-OHBENZOATE-DECARBOX-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.1.1.98"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R04986"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102201"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27778"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27780"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27779"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27781"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn03393"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-10.62899607243969"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.07491153153616827"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_3ophb_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
@@ -4187,8 +30312,29 @@
           <speciesReference species="M_2oph_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_OPHHX3" name="R_OPHHX3" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:and>
+            <fbc:geneProductRef fbc:geneProduct="G_b3843"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2311"/>
+          </fbc:and>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_OPHHX3" sboTerm="SBO:0000176" id="R_OPHHX3" name="2-Octaprenylphenol hydroxylase (anaerobic)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_OPHHX3">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/OPHHX3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102204"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09045"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-39.38514493354535"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-1.198609603083812"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_2oph_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_atp_c" stoichiometry="2" constant="true"/>
@@ -4203,7 +30349,22 @@
           <speciesReference species="M_pi_c" stoichiometry="2" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction id="R_OPMEACPD" name="R_OPMEACPD" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+      <reaction metaid="meta_R_OPMEACPD" sboTerm="SBO:0000176" id="R_OPMEACPD" name="3-Oxo-pimeloyl-[ACP] methyl ester dehydratase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_OPMEACPD">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/OPMEACPD"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN-11481"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.2.1.59"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R10121"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102206"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_hpmeACP_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
@@ -4211,8 +30372,23 @@
           <speciesReference species="M_epmeACP_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_OPMEACPR" name="R_OPMEACPR" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0180"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_OPMEACPR" sboTerm="SBO:0000176" id="R_OPMEACPR" name="3-Oxo-pimeloyl-[ACP] methyl ester reductase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_OPMEACPR">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/OPMEACPR"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102207"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
@@ -4222,8 +30398,23 @@
           <speciesReference species="M_hpmeACP_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_OPMEACPS" name="R_OPMEACPS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b1093"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_OPMEACPS" sboTerm="SBO:0000176" id="R_OPMEACPS" name="3-Oxo-pimeloyl-[ACP] methyl ester synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_OPMEACPS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/OPMEACPS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102208"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_gmeACP_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
@@ -4234,8 +30425,53 @@
           <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_opmeACP_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_ORPT" name="R_ORPT" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b2323"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_ORPT" sboTerm="SBO:0000176" id="R_ORPT" name="Orotate phosphoribosyltransferase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ORPT">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ORPT"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:OROPRIBTRANS-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.4.2.10"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01870"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102231"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-73567"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-73567"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-73567"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-73567"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-73567"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-73567"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-73567"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-73567"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-73567"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-73567"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-73567"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-419462"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-73567"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-73567"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-73567"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-73567"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-73567"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-73567"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-73567"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10381"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10383"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10382"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10380"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/401"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01362"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-9.427648718238174"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/4.811038720187177e-15"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_orot5p_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
@@ -4244,8 +30480,49 @@
           <speciesReference species="M_orot_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_prpp_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_P5CR" name="R_P5CR" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3642"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_P5CR" sboTerm="SBO:0000176" id="R_P5CR" name="Pyrroline-5-carboxylate reductase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_P5CR">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/P5CR"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.5.1.2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01251"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102302"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-6783955"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-6783955"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-6783955"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-6783955"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-6783955"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-6783955"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-6783955"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-6783955"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-6783955"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-6783955"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-6783955"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-6783955"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-6783955"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-6783955"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-6783955"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-6783955"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14111"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14112"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14109"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14110"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/1470"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00931"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-20.58840965979249"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.3415966424645517"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_1pyr5c_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="2" constant="true"/>
@@ -4255,8 +30532,32 @@
           <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pro__L_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PANTS" name="R_PANTS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0386"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PANTS" sboTerm="SBO:0000176" id="R_PANTS" name="Pantothenate synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PANTS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PANTS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:PANTOATE-BETA-ALANINE-LIG-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/6.3.2.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R02473"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102345"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10914"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10913"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10915"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10912"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/2406"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01791"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_ala__B_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
@@ -4268,8 +30569,27 @@
           <speciesReference species="M_pnto__R_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PAPPT3" name="R_PAPPT3" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0133"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PAPPT3" sboTerm="SBO:0000176" id="R_PAPPT3" name="Phospho-N-acetylmuramoyl-pentapeptide-transferase (meso-2,6-diaminopimelate)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PAPPT3">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PAPPT3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.8.13"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102373"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn03904"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/1.369454450968874"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.13665841749701582"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_udcpp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ugmda_c" stoichiometry="1" constant="true"/>
@@ -4278,8 +30598,25 @@
           <speciesReference species="M_uagmda_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ump_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PAPSR2" name="R_PAPSR2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0087"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PAPSR2" sboTerm="SBO:0000176" id="R_PAPSR2" name="Phosphoadenylyl-sulfate reductase (glutaredoxin)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PAPSR2">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PAPSR2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.8.4.8"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102377"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09069"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_grxrd_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_paps_c" stoichiometry="1" constant="true"/>
@@ -4290,8 +30627,73 @@
           <speciesReference species="M_pap_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_so3_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PDH" name="R_PDH" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b2762"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b0849"/>
+            </fbc:and>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b2762"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b1064"/>
+            </fbc:and>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b2762"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b1654"/>
+            </fbc:and>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b2762"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b3610"/>
+            </fbc:and>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PDH" sboTerm="SBO:0000176" id="R_PDH" name="Pyruvate dehydrogenase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PDH">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PDH"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:PYRUVDEH-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.2.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.8.1.4"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.2.1.51"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.2.4.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.1.12"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00209"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102425"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-71397"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-71397"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-373177"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-71397"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-71397"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-71397"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-71397"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-71397"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-71397"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-71397"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-71397"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-71397"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-71397"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-71397"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-71397"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-71397"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-71397"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-71397"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28043"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28045"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28044"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28042"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/523"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00154"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-34.17613680283739"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.008535499964858806"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
@@ -4302,8 +30704,30 @@
           <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PDX5PO2" name="R_PDX5PO2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:and>
+            <fbc:geneProductRef fbc:geneProduct="G_b0114"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0115"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0116"/>
+          </fbc:and>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PDX5PO2" sboTerm="SBO:0000176" id="R_PDX5PO2" name="Pyridoxine 5&apos;-phosphate oxidase (anaerboic" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PDX5PO2">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PDX5PO2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102437"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09071"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/19.769652920141766"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.016796763922159785"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pdx5p_c" stoichiometry="1" constant="true"/>
@@ -4314,7 +30738,22 @@
           <speciesReference species="M_pydx5p_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction id="R_PDX5PS" name="R_PDX5PS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+      <reaction metaid="meta_R_PDX5PS" sboTerm="SBO:0000176" id="R_PDX5PS" name="Pyridoxine 5&apos;-phosphate synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PDX5PS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PDX5PS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102439"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09072"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-221.34894219084276"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.004564720217353555"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_dxyl5p_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
@@ -4328,8 +30767,29 @@
           <speciesReference species="M_pdx5p_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PE160abcpp" name="R_PE160abcpp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:and>
+            <fbc:geneProductRef fbc:geneProduct="G_b0052"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2564"/>
+          </fbc:and>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PE160abcpp" sboTerm="SBO:0000185" id="R_PE160abcpp" name="Phosphatidylethanolamine transport via ABC system (n-C16:0, periplasm)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PE160abcpp">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PE160abcpp"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102444"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09076"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-29.20837230399522"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.3042787597905381"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
@@ -4341,8 +30801,23 @@
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pe160_p" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PE161abcpp" name="R_PE161abcpp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0914"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PE161abcpp" sboTerm="SBO:0000185" id="R_PE161abcpp" name="Phosphatidylethanolamine transport via ABC system (n-C16:1, periplasm)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PE161abcpp">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PE161abcpp"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102445"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
@@ -4354,8 +30829,33 @@
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pe161_p" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PERD" name="R_PERD" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0914"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PERD" sboTerm="SBO:0000176" id="R_PERD" name="Erythronate 4-phosphate (4per) dehydrogenase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PERD">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PERD"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:ERYTHRON4PDEHYDROG-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.290"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R04210"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102495"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18831"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18830"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18832"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18829"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn02939"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/18.860356315321155"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.03257183377291151"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_4per_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
@@ -4365,8 +30865,30 @@
           <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ohpb_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PFK" name="R_PFK" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b2320"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PFK" sboTerm="SBO:0000176" id="R_PFK" name="Phosphofructokinase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PFK">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PFK"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.1.11"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102507"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16111"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16109"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16110"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16112"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-19.117199878630117"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.026976052871656147"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_f6p_c" stoichiometry="1" constant="true"/>
@@ -4376,8 +30898,37 @@
           <speciesReference species="M_fdp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PFL" name="R_PFL" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b3916"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b1723"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PFL" sboTerm="SBO:0000176" id="R_PFL" name="Pyruvate formate lyase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PFL">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PFL"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:PYRUVFORMLY-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.1.54"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00212"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102514"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11847"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11845"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11844"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11846"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/146"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00157"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-20.13551469874583"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0004378901385389194"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
@@ -4386,16 +30937,102 @@
           <speciesReference species="M_accoa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_for_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PGAMT" name="R_PGAMT" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b0902"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b0903"/>
+            </fbc:and>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b0902"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b3114"/>
+            </fbc:and>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b3951"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b3952"/>
+            </fbc:and>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b0902"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b0903"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2579"/>
+            </fbc:and>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PGAMT" sboTerm="SBO:0000176" id="R_PGAMT" name="Phosphoglucosamine mutase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PGAMT">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PGAMT"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:5.4.2.10-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/5.4.2.10"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R02060"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102526"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23427"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23425"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23426"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23424"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/2077"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01485"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-2.6655064810588556"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/2.9047944605231635e-15"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_gam1p_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_gam6p_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PGCD" name="R_PGCD" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3176"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PGCD" sboTerm="SBO:0000176" id="R_PGCD" name="Phosphoglycerate dehydrogenase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PGCD">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PGCD"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:PGLYCDEHYDROG-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.95"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01513"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102527"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-977348"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-977348"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-977348"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-977348"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-977348"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-977348"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-977348"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-977348"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-977348"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-977348"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-977348"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-977348"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-977348"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-977348"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-977348"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-977348"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12644"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12643"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12642"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12641"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/8970"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01101"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/33.55147053096698"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0005608557753733479"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_3pg_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
@@ -4405,16 +31042,99 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PGI" name="R_PGI" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b2913"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PGI" sboTerm="SBO:0000176" id="R_PGI" name="Glucose-6-phosphate isomerase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PGI">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PGI"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:PGLUCISOM-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/5.3.1.9"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102535"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/7.118525031156537"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.025878202444730162"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_g6p_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_f6p_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PGK" name="R_PGK" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b4025"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PGK" sboTerm="SBO:0000176" id="R_PGK" name="Phosphoglycerate kinase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
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+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-71850"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-71850"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-70486"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-71850"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14801"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14804"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14802"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14803"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/7644"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01100"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.0004002080634641248"/>
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+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_3pg_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
@@ -4423,8 +31143,50 @@
           <speciesReference species="M_13dpg_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PGL" name="R_PGL" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b2926"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PGL" sboTerm="SBO:0000176" id="R_PGL" name="6-phosphogluconolactonase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PGL">
+              <bqbiol:is>
+                <rdf:Bag>
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+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:6PGLUCONOLACT-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.1.1.31"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R02035"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102539"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-71296"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-71296"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-71296"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-71296"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-71296"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-71296"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-71296"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-71296"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-71296"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-71296"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-71296"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-71296"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-71296"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-71296"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-71296"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12559"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12556"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12557"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12558"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/109"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01476"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-22.68304013475762"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0010325587184541127"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_6pgl_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
@@ -4433,16 +31195,115 @@
           <speciesReference species="M_6pgc_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PGM" name="R_PGM" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0767"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PGM" sboTerm="SBO:0000176" id="R_PGM" name="Phosphoglycerate mutase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PGM">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PGM"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:3PGAREARR-RXN"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/5.4.2.1"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-71445"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-71445"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-71654"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15902"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/7641"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01106"/>
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+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_2pg_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_3pg_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PHETA1" name="R_PHETA1" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b3612"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b4395"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0755"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PHETA1" sboTerm="SBO:0000176" id="R_PHETA1" name="Phenylalanine transaminase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PHETA1">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PHETA1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:PHEAMINOTRANS-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN-10814"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.6.1.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00694"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR126234"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/25153"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/25155"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/25152"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/25154"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/1074"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00493"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-14.47125085906697"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.49375212168570043"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_akg_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_phe__L_c" stoichiometry="1" constant="true"/>
@@ -4451,8 +31312,40 @@
           <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_phpyr_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PIt2rpp" name="R_PIt2rpp" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b4054"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0928"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b3770"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PIt2rpp" sboTerm="SBO:0000185" id="R_PIt2rpp" name="Phosphate reversible transport via symport (periplasm)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PIt2rpp">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PIt2rpp"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:TRANS-RXN-114"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102872"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29939"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29941"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29940"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29942"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn05312"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09833"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09811"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09872"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09723"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09120"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/11.84667962644145"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h_p" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pi_p" stoichiometry="1" constant="true"/>
@@ -4461,16 +31354,77 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PItex" name="R_PItex" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b2987"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b3493"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PItex" sboTerm="SBO:0000185" id="R_PItex" name="Phosphate transport via diffusion (extracellular to periplasm)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PItex">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PItex"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:TRANS-RXN0-470"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102871"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/32824"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/32826"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/32825"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/32823"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/10985"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn10838"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09722"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09121"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn13178"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/28.9455"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_pi_e" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_pi_p" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PMDPHT" name="R_PMDPHT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b0241"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0929"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b1377"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2215"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PMDPHT" sboTerm="SBO:0000176" id="R_PMDPHT" name="Pyrimidine phosphatase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PMDPHT">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PMDPHT"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RIBOPHOSPHAT-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.1.3.104"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.1.3.-"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R07280"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR96145"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/25197"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/25200"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/25198"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/25199"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn05039"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-15.887424220861988"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.07291169775010718"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_5aprbu_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
@@ -4480,7 +31434,22 @@
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction id="R_PMEACPE" name="R_PMEACPE" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+      <reaction metaid="meta_R_PMEACPE" sboTerm="SBO:0000176" id="R_PMEACPE" name="Pimeloyl-[ACP] methyl ester esterase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PMEACPE">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PMEACPE"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN-11483"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.1.1.85"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R09725"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR103041"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pmeACP_c" stoichiometry="1" constant="true"/>
@@ -4489,8 +31458,27 @@
           <speciesReference species="M_meoh_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pimACP_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PMPK" name="R_PMPK" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3412"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PMPK" sboTerm="SBO:0000176" id="R_PMPK" name="Phosphomethylpyrimidine kinase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PMPK">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PMPK"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.4.7"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR143305"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn03108"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/8.493369357760798"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.02471139595286322"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_4ampm_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
@@ -4499,8 +31487,60 @@
           <speciesReference species="M_2mahmp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PNTK" name="R_PNTK" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b2103"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PNTK" sboTerm="SBO:0000176" id="R_PNTK" name="Pantothenate kinase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PNTK">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PNTK"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:PANTOTHENATE-KIN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.1.33"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R03018"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR103050"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-199203"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-199203"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-196857"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-196857"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-199203"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-199203"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-199203"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-199203"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-196857"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-199203"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-196857"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-199203"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-196857"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-196857"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-199203"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-199203"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-199203"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-196857"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-196857"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-199203"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-196857"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-196857"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-196857"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-196857"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-199203"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-196857"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16376"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16375"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16373"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16374"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/2868"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn12510"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-14.15273914292095"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.07243488600608568"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pnto__R_c" stoichiometry="1" constant="true"/>
@@ -4510,8 +31550,30 @@
           <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_POX" name="R_POX" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3974"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_POX" sboTerm="SBO:0000176" id="R_POX" name="Pyruvate oxidase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_POX">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/POX"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR103067"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29168"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29170"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29167"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29169"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09167"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-200.598859963692"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.12758065768690763"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
@@ -4522,8 +31584,50 @@
           <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_q8h2_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PPBNGS" name="R_PPBNGS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0871"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PPBNGS" sboTerm="SBO:0000176" id="R_PPBNGS" name="Porphobilinogen synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PPBNGS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PPBNGS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:PORPHOBILSYNTH-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.2.1.24"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00036"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR103095"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-421472"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-189439"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-189439"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-189439"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-189439"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-189439"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-189439"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-189439"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-189439"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-189439"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-189439"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-189439"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-189439"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-189439"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-189439"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-189439"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-189439"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24064"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24066"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24067"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24065"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00029"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-102.2712476400306"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.8311482609349365"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_5aop_c" stoichiometry="2" constant="true"/>
         </listOfReactants>
@@ -4532,8 +31636,33 @@
           <speciesReference species="M_h2o_c" stoichiometry="2" constant="true"/>
           <speciesReference species="M_ppbng_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PPC" name="R_PPC" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0369"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PPC" sboTerm="SBO:0000176" id="R_PPC" name="Phosphoenolpyruvate carboxylase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PPC">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PPC"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.1.1.31"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00345"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR103096"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23073"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23072"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23075"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23074"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/150"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00251"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-37.700927375365396"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.0028106488039349653"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
@@ -4544,8 +31673,51 @@
           <speciesReference species="M_oaa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PPCDC" name="R_PPCDC" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3956"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PPCDC" sboTerm="SBO:0000176" id="R_PPCDC" name="Phosphopantothenoylcysteine decarboxylase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PPCDC">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PPCDC"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:P-PANTOCYSDECARB-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.1.1.36"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R03269"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR103098"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-196840"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-196840"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-196840"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-196840"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-196840"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-196840"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-196840"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-196840"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-196840"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-196840"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-196840"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-196840"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-196840"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-196840"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-196840"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-196840"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-196840"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16793"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16796"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16794"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16795"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/3090"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn02341"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-21.23862360800615"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.07494870599231163"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_4ppcys_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
@@ -4554,8 +31726,34 @@
           <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pan4p_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PPCK" name="R_PPCK" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3639"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PPCK" sboTerm="SBO:0000176" id="R_PPCK" name="Phosphoenolpyruvate carboxykinase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PPCK">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PPCK"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:PEPCARBOXYKIN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.1.1.49"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00341"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR103099"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18620"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18618"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18617"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18619"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/151"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00247"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/10.934835627257016"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.003287460547956987"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_oaa_c" stoichiometry="1" constant="true"/>
@@ -4565,8 +31763,23 @@
           <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pep_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PPKr" name="R_PPKr" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3403"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PPKr" id="R_PPKr" name="R_PPKr" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PPKr">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-11.577967956683821"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0003925037026249415"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
@@ -4576,15 +31789,63 @@
           <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction id="R_PPM" name="R_PPM" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+      <reaction metaid="meta_R_PPM" sboTerm="SBO:0000176" id="R_PPM" name="Phosphopentomutase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PPM">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PPM"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN-14456"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/5.4.2.7"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/5.4.2.2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/5.4.2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR103115"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/2261"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-13.8076005083376"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.10186020967755913"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_r1p_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_r5p_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PPNCL2" name="R_PPNCL2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b3380"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b4383"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PPNCL2" sboTerm="SBO:0000176" id="R_PPNCL2" name="Phosphopantothenate-cysteine ligase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PPNCL2">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PPNCL2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:P-PANTOCYSLIG-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/6.3.2.5"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R04231"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR103119"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/19399"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/19400"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/19397"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/19398"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/3942"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09177"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-52.50815203898257"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.022477329407883898"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_4ppan_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ctp_c" stoichiometry="1" constant="true"/>
@@ -4596,8 +31857,34 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PPND" name="R_PPND" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3639"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PPND" sboTerm="SBO:0000176" id="R_PPND" name="Prephenate dehydrogenase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PPND">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PPND"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:PREPHENATEDEHYDROG-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.1.12"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01728"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR103121"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13872"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13870"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13869"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13871"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/1839"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01268"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-10.156365484171147"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/2.855416740285267"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pphn_c" stoichiometry="1" constant="true"/>
@@ -4607,8 +31894,35 @@
           <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PPNDH" name="R_PPNDH" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b2600"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PPNDH" sboTerm="SBO:0000176" id="R_PPNDH" name="Prephenate dehydratase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PPNDH">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PPNDH"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:PREPHENATEDEHYDRAT-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.2.1.91"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.2.1.51"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01373"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR126086"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21648"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21649"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21650"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21651"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/1575"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01000"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-81.84394020371136"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/3.3457716540781686"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pphn_c" stoichiometry="1" constant="true"/>
@@ -4618,8 +31932,27 @@
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_phpyr_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PPPGO3" name="R_PPPGO3" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b2599"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PPPGO3" sboTerm="SBO:0000176" id="R_PPPGO3" name="Protoporphyrinogen oxidase (anaerobic)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PPPGO3">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PPPGO3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.3.4"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR103130"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09180"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-128.76417636712216"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/25.426985618362835"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_fum_c" stoichiometry="3" constant="true"/>
           <speciesReference species="M_pppg9_c" stoichiometry="1" constant="true"/>
@@ -4628,8 +31961,34 @@
           <speciesReference species="M_ppp9_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_succ_c" stoichiometry="3" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PPS" name="R_PPS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3850"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PPS" sboTerm="SBO:0000176" id="R_PPS" name="Phosphoenolpyruvate synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PPS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PPS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:PEPSYNTH-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.9.2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00199"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR103140"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11364"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11367"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11366"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11365"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/148"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00147"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/1.7921532658481851"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.00026671463697478665"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
@@ -4641,8 +32000,29 @@
           <speciesReference species="M_pep_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PRAGSr" name="R_PRAGSr" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b1702"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PRAGSr" sboTerm="SBO:0000176" id="R_PRAGSr" name="Phosphoribosylglycinamide synthase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PRAGSr">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PRAGSr"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:GLYRIBONUCSYN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/6.3.4.13"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R04144"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR103139"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn02895"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-25.465574325300906"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.014652228693881724"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_gly_c" stoichiometry="1" constant="true"/>
@@ -4654,8 +32034,30 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PRAIS" name="R_PRAIS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b4005"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PRAIS" sboTerm="SBO:0000176" id="R_PRAIS" name="Phosphoribosylaminoimidazole synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PRAIS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PRAIS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/6.3.3.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR138720"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23033"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23032"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23034"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23035"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/5.753777597984538"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.49848530059879903"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_fpram_c" stoichiometry="1" constant="true"/>
@@ -4666,16 +32068,66 @@
           <speciesReference species="M_h_c" stoichiometry="2" constant="true"/>
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PRAIi" name="R_PRAIi" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b2499"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PRAIi" sboTerm="SBO:0000176" id="R_PRAIi" name="Phosphoribosylanthranilate isomerase (irreversible)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PRAIi">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PRAIi"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:PRAISOM-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/5.3.1.24"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R03509"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR103156"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21543"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21542"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21540"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21541"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn02508"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-9.826198200800604"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.08272775632355067"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_pran_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_2cpr5p_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PRAMPC" name="R_PRAMPC" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b1262"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PRAMPC" sboTerm="SBO:0000176" id="R_PRAMPC" name="Phosphoribosyl-AMP cyclohydrolase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PRAMPC">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PRAMPC"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:HISTCYCLOHYD-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.5.4.19"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R04037"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR103154"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/20049"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/20050"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/20051"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/20052"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn02835"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-2706.807600811295"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/1.47710916626215"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_prbamp_c" stoichiometry="1" constant="true"/>
@@ -4683,8 +32135,45 @@
         <listOfProducts>
           <speciesReference species="M_prfp_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PRASCSi" name="R_PRASCSi" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b2026"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PRASCSi" sboTerm="SBO:0000176" id="R_PRASCSi" name="Phosphoribosylaminoimidazolesuccinocarboxamide synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PRASCSi">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PRASCSi"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:SAICARSYN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/6.3.2.6"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R04591"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR108987"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-73805"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-73805"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-419223"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-73805"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-73805"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-73805"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-73805"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-73805"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-73805"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-73805"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-73805"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-73805"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-73805"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22631"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22628"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22629"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22630"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-73.66631729573766"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.1780530601401978"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_5aizc_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_asp__L_c" stoichiometry="1" constant="true"/>
@@ -4696,8 +32185,33 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PRATPP" name="R_PRATPP" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b2476"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PRATPP" sboTerm="SBO:0000176" id="R_PRATPP" name="Phosphoribosyl-ATP pyrophosphatase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PRATPP">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PRATPP"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:HISTPRATPHYD-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.1.31"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R04035"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR103155"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22829"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22828"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22830"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22831"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn02834"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-1816.3501658749312"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.0026402466558556204"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_prbatp_c" stoichiometry="1" constant="true"/>
@@ -4707,8 +32221,47 @@
           <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_prbamp_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PRFGS" name="R_PRFGS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b2026"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PRFGS" sboTerm="SBO:0000176" id="R_PRFGS" name="Phosphoribosylformylglycinamidine synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PRFGS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PRFGS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/6.3.5.3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR138721"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-73812"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-73812"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-73812"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-73812"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-73812"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-73812"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-73812"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-73812"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-73812"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-73812"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-73812"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-73812"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-419144"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-73812"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-73812"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-73812"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-73812"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17132"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17129"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17131"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17130"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/31.539803909826958"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/1.2203736445834503"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_fgam_c" stoichiometry="1" constant="true"/>
@@ -4722,16 +32275,66 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PRMICI" name="R_PRMICI" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b2557"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PRMICI" sboTerm="SBO:0000176" id="R_PRMICI" name="1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PRMICI">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PRMICI"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:PRIBFAICARPISOM-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/5.3.1.16"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R04640"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR103169"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15471"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15472"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15469"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15470"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn03175"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-9.76698401995975"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.0827277563235489"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_prfp_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_prlp_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PROt2rpp" name="R_PROt2rpp" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b2024"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PROt2rpp" sboTerm="SBO:0000185" id="R_PROt2rpp" name="L-proline reversible transport via proton symport (periplasm)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PROt2rpp">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PROt2rpp"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:TRANS-RXN-29"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR103211"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28963"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28964"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28965"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28966"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn11167"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09191"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn05638"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-17.325693124292542"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h_p" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pro__L_p" stoichiometry="1" constant="true"/>
@@ -4740,8 +32343,41 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pro__L_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PROt4pp" name="R_PROt4pp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b4111"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PROt4pp" sboTerm="SBO:0000185" id="R_PROt4pp" name="Na+/Proline-L symporter (periplasm)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PROt4pp">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PROt4pp"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:TRANS-RXN-118"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR103197"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-352052"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-352052"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-352052"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-352052"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-352052"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-352052"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-352052"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-352052"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-352052"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28968"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28969"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28970"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28967"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn05221"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09192"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-14.149148431432161"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_na1_p" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pro__L_p" stoichiometry="1" constant="true"/>
@@ -4750,8 +32386,26 @@
           <speciesReference species="M_na1_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pro__L_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PRPPS" name="R_PRPPS" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b1015"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PRPPS" sboTerm="SBO:0000176" id="R_PRPPS" name="Phosphoribosylpyrophosphate synthetase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PRPPS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PRPPS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.6.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR103215"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/2.686343159897035"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.1001734120760312"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_r5p_c" stoichiometry="1" constant="true"/>
@@ -4761,8 +32415,35 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_prpp_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PSCVT" name="R_PSCVT" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b1207"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PSCVT" sboTerm="SBO:0000176" id="R_PSCVT" name="3-phosphoshikimate 1-carboxyvinyltransferase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PSCVT">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PSCVT"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:2.5.1.19-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.5.1.19"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R03460"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR103226"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MTU-964886"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21259"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21257"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21256"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21258"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/3254"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn02476"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-16.59609565417054"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.04473880092541705"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_pep_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_skm5p_c" stoichiometry="1" constant="true"/>
@@ -4771,8 +32452,27 @@
           <speciesReference species="M_3psme_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PSD160" name="R_PSD160" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0908"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PSD160" sboTerm="SBO:0000176" id="R_PSD160" name="Phosphatidylserine decarboxylase (n-C16:0)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PSD160">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PSD160"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.1.1.65"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR103232"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09200"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-19.670214363475225"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.07494870599231107"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ps160_c" stoichiometry="1" constant="true"/>
@@ -4781,8 +32481,24 @@
           <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pe160_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PSD161" name="R_PSD161" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b4160"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PSD161" sboTerm="SBO:0000176" id="R_PSD161" name="Phosphatidylserine decarboxylase (n-C16:1)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PSD161">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PSD161"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.1.1.65"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR103233"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ps161_c" stoichiometry="1" constant="true"/>
@@ -4791,8 +32507,51 @@
           <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pe161_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PSERT" name="R_PSERT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b4160"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PSERT" sboTerm="SBO:0000176" id="R_PSERT" name="Phosphoserine transaminase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PSERT">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PSERT"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:PSERTRANSAM-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.6.1.52"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R04173"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR103225"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-977333"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-977333"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-977333"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-977333"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-977333"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-977333"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-977333"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-977333"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-977333"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-977333"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-977333"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-977333"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-977333"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-977333"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-977333"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-977333"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-977333"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14331"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14329"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14330"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14332"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/3893"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn02914"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-10.28760362156413"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/5.197295048617735e-05"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_3php_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
@@ -4801,8 +32560,52 @@
           <speciesReference species="M_akg_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pser__L_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PSP_L" name="R_PSP_L" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0907"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PSP_L" sboTerm="SBO:0000176" id="R_PSP_L" name="Phosphoserine phosphatase (L-serine)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PSP_L">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PSP_L"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN0-5114"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.1.3.3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00582"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR103260"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-977324"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-977324"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-977324"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-977324"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-977324"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-977324"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-977324"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-977324"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-977324"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-977324"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-977324"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-977324"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-977324"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-977324"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-977324"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-977324"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-977324"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21208"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21211"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21210"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21209"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/10330"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/983"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00420"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-11.088154986906545"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/1.4455423906434826e-05"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pser__L_c" stoichiometry="1" constant="true"/>
@@ -4811,8 +32614,25 @@
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ser__L_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PSSA160" name="R_PSSA160" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b4388"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PSSA160" sboTerm="SBO:0000176" id="R_PSSA160" name="Phosphatidylserine syntase (n-C16:0)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PSSA160">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PSSA160"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.8.8"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR103269"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09208"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_cdpdhdecg_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ser__L_c" stoichiometry="1" constant="true"/>
@@ -4822,8 +32642,24 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ps160_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PSSA161" name="R_PSSA161" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b2585"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PSSA161" sboTerm="SBO:0000176" id="R_PSSA161" name="Phosphatidylserine syntase (n-C16:1)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PSSA161">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PSSA161"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.8.8"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR103270"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_cdpdhdec9eg_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ser__L_c" stoichiometry="1" constant="true"/>
@@ -4833,8 +32669,34 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ps161_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PTAr" name="R_PTAr" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b2585"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PTAr" sboTerm="SBO:0000176" id="R_PTAr" name="Phosphotransacetylase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PTAr">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PTAr"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:PHOSACETYLTRANS-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.1.8"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00230"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR103319"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/19521"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/19523"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/19522"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/19524"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/72"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00173"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/10.124507857796289"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/4.293076378458771e-05"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_accoa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
@@ -4843,8 +32705,55 @@
           <speciesReference species="M_actp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PTPATi" name="R_PTPATi" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b2297"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2458"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PTPATi" sboTerm="SBO:0000176" id="R_PTPATi" name="Pantetheine-phosphate adenylyltransferase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PTPATi">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PTPATi"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:PANTEPADENYLYLTRAN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.7.3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R03035"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95892"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-196754"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-196754"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-196754"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-196754"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-196754"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-196754"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-196754"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-196754"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-196754"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-196754"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-196754"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-196754"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-196754"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-196754"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-196754"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-196754"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-196754"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/19803"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/19802"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/19801"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/19804"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/2884"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/12078"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn02175"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-21.22829573040046"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.040039410900905445"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
@@ -4854,8 +32763,34 @@
           <speciesReference species="M_dpcoa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PUNP1" name="R_PUNP1" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3634"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PUNP1" sboTerm="SBO:0000176" id="R_PUNP1" name="Purine-nucleoside phosphorylase (Adenosine)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PUNP1">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PUNP1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:ADENPHOSPHOR-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.4.2.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01561"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR103343"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27644"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27645"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27643"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27642"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/133"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01138"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/7.695797618705285"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.00042977446980057676"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_adn_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
@@ -4864,8 +32799,32 @@
           <speciesReference species="M_ade_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_r1p_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PUNP2" name="R_PUNP2" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b4384"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PUNP2" sboTerm="SBO:0000176" id="R_PUNP2" name="Purine-nucleoside phosphorylase (Deoxyadenosine)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PUNP2">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PUNP2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:DEOXYADENPHOSPHOR-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.4.2.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R02557"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR103344"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27743"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27742"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27745"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27744"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/342"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01859"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_dad__2_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
@@ -4874,8 +32833,53 @@
           <speciesReference species="M_2dr1p_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ade_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PYK" name="R_PYK" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b4384"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PYK" sboTerm="SBO:0000176" id="R_PYK" name="Pyruvate kinase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PYK">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PYK"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:PEPDEPHOS-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.1.40"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00200"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR103371"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-71670"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-353056"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-71670"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-71670"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-71670"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-71670"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-71670"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-71670"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-71670"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-71670"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-71670"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-71670"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-71670"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-71670"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-71670"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-71670"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-71670"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-71670"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-71670"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18160"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18159"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18158"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18157"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/9"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00148"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-28.406684930344326"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.000685334179060631"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
@@ -4885,8 +32889,38 @@
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_PYNP2r" name="R_PYNP2r" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b1854"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b1676"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_PYNP2r" sboTerm="SBO:0000176" id="R_PYNP2r" name="Pyrimidine-nucleoside phosphorylase (uracil)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PYNP2r">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PYNP2r"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:URPHOS-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.4.2.3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.4.2.2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01876"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR103377"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24391"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24388"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24390"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24389"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/204"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01366"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/0.610989742021701"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-6.106226635438361e-16"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_uri_c" stoichiometry="1" constant="true"/>
@@ -4895,8 +32929,33 @@
           <speciesReference species="M_r1p_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ura_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_QULNS" name="R_QULNS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3831"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_QULNS" sboTerm="SBO:0000176" id="R_QULNS" name="Quinolinate synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_QULNS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/QULNS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:QUINOLINATE-SYNTHA-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.5.1.72"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R04292"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR103400"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/25889"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/25891"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/25890"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/25888"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn02988"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-217.886286931579"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/1.4645038288235233"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_dhap_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_iasp_c" stoichiometry="1" constant="true"/>
@@ -4906,8 +32965,49 @@
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_quln_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_RBFK" name="R_RBFK" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0750"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_RBFK" sboTerm="SBO:0000176" id="R_RBFK" name="Riboflavin kinase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_RBFK">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/RBFK"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RIBOFLAVINKIN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.1.26"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00549"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR103429"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-196964"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-196964"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-196964"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-196964"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-196964"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-196964"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-196964"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-196964"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-196964"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-196964"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-196964"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-196964"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-196964"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-196964"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-196964"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14360"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14359"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14358"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14357"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/277"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00392"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-10.253994869066787"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.29915659983176823"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ribflv_c" stoichiometry="1" constant="true"/>
@@ -4917,8 +33017,30 @@
           <speciesReference species="M_fmn_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_RBFSa" name="R_RBFSa" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0025"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_RBFSa" sboTerm="SBO:0000176" id="R_RBFSa" name="Riboflavin synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_RBFSa">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/RBFSa"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.5.1.9"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.5.1.78"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R04457"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97501"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/8561"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn03080"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-96.76471742593876"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.2567967749122812"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_4r5au_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_db4p_c" stoichiometry="1" constant="true"/>
@@ -4928,8 +33050,34 @@
           <speciesReference species="M_h2o_c" stoichiometry="2" constant="true"/>
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_RBFSb" name="R_RBFSb" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b1662"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_RBFSb" sboTerm="SBO:0000176" id="R_RBFSb" name="Riboflavin synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_RBFSb">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/RBFSb"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RIBOFLAVIN-SYN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.5.1.9"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00066"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR103430"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/20773"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/20774"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/20775"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/20772"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/653"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00048"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-99.70234404754751"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-2.806983500414538"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_dmlz_c" stoichiometry="2" constant="true"/>
         </listOfReactants>
@@ -4937,8 +33085,35 @@
           <speciesReference species="M_4r5au_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ribflv_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_RHCCE" name="R_RHCCE" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0415"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_RHCCE" sboTerm="SBO:0000176" id="R_RHCCE" name="S-ribosylhomocysteine cleavage enzyme" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_RHCCE">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/RHCCE"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RIBOSYLHOMOCYSTEINASE-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.4.1.21"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01291"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104026"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17754"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17753"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17756"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17755"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/6873"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn14169"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn05958"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-13.695215344775022"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.2024333678496235"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_rhcys_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
@@ -4946,8 +33121,23 @@
           <speciesReference species="M_dhptd_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_hcys__L_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_RNTR1c2" name="R_RNTR1c2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b2687"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_RNTR1c2" sboTerm="SBO:0000176" id="R_RNTR1c2" name="Ribonucleoside-triphosphate reductase (ATP) (flavodoxin)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_RNTR1c2">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/RNTR1c2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104072"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_flxr_c" stoichiometry="2" constant="true"/>
@@ -4958,8 +33148,44 @@
           <speciesReference species="M_flxso_c" stoichiometry="2" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_RNTR2c2" name="R_RNTR2c2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b0684"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b3924"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b4238"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b4237"/>
+            </fbc:and>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b2895"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b3924"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b4238"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b4237"/>
+            </fbc:and>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b0684"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b4238"/>
+            </fbc:and>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b2895"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b4238"/>
+            </fbc:and>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_RNTR2c2" sboTerm="SBO:0000176" id="R_RNTR2c2" name="Ribonucleoside-triphosphate reductase (GTP) (flavodoxin)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_RNTR2c2">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/RNTR2c2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104075"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_flxr_c" stoichiometry="2" constant="true"/>
           <speciesReference species="M_gtp_c" stoichiometry="1" constant="true"/>
@@ -4970,8 +33196,44 @@
           <speciesReference species="M_flxso_c" stoichiometry="2" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_RNTR3c2" name="R_RNTR3c2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b0684"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b3924"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b4238"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b4237"/>
+            </fbc:and>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b2895"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b3924"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b4238"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b4237"/>
+            </fbc:and>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b0684"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b4238"/>
+            </fbc:and>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b2895"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b4238"/>
+            </fbc:and>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_RNTR3c2" sboTerm="SBO:0000176" id="R_RNTR3c2" name="Ribonucleoside-triphosphate reductase (CTP) (flavodoxin)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_RNTR3c2">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/RNTR3c2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104078"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_ctp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_flxr_c" stoichiometry="2" constant="true"/>
@@ -4982,24 +33244,151 @@
           <speciesReference species="M_flxso_c" stoichiometry="2" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_RPE" name="R_RPE" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b0684"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b3924"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b4238"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b4237"/>
+            </fbc:and>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b2895"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b3924"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b4238"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b4237"/>
+            </fbc:and>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b0684"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b4238"/>
+            </fbc:and>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b2895"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b4238"/>
+            </fbc:and>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_RPE" sboTerm="SBO:0000176" id="R_RPE" name="Ribulose 5-phosphate 3-epimerase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_RPE">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/RPE"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RIBULP3EPIM-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/5.1.3.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01529"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104083"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-71303"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-199803"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-71303"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-71303"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-71303"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-199803"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-199803"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-199803"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-199803"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-71303"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-199803"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-71303"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-71303"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-71303"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-71303"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-199803"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-71303"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-199803"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-199803"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-71303"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-71303"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-71303"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-199803"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-71303"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-199803"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-199803"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-199803"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-71303"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-71303"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-199803"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-71303"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-199803"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-71303"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-199803"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-199803"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-199803"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13677"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13680"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13678"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13679"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/62"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01116"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-3.3935694299275383"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0008101477973079954"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_ru5p__D_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_xu5p__D_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_RPI" name="R_RPI" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b4301"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b3386"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_RPI" sboTerm="SBO:0000176" id="R_RPI" name="Ribose-5-phosphate isomerase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_RPI">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/RPI"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/5.3.1.6"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104084"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/4.397665002183999"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.10296351955814127"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_r5p_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_ru5p__D_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_SADT2" name="R_SADT2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b2914"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b4090"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_SADT2" sboTerm="SBO:0000176" id="R_SADT2" name="Sulfate adenyltransferase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_SADT2">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/SADT2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.7.4"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104241"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn11356"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09240"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/21.34279889408812"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.000596811793556867"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_gtp_c" stoichiometry="1" constant="true"/>
@@ -5012,8 +33401,35 @@
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_SDPDS" name="R_SDPDS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:and>
+            <fbc:geneProductRef fbc:geneProduct="G_b2751"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2752"/>
+          </fbc:and>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_SDPDS" sboTerm="SBO:0000176" id="R_SDPDS" name="Succinyl-diaminopimelate desuccinylase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_SDPDS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/SDPDS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:SUCCDIAMINOPIMDESUCC-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.5.1.18"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R02734"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104300"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22611"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22608"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22610"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22609"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/2621"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01973"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_sl26da_c" stoichiometry="1" constant="true"/>
@@ -5022,8 +33438,33 @@
           <speciesReference species="M_26dap__LL_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_succ_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_SDPTA" name="R_SDPTA" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b2472"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_SDPTA" sboTerm="SBO:0000176" id="R_SDPTA" name="Succinyldiaminopimelate transaminase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_SDPTA">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/SDPTA"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:SUCCINYLDIAMINOPIMTRANS-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.6.1.17"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R04475"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104301"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11960"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11961"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11963"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11962"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn03087"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-2.2840380832105893"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-5.717648576819556e-15"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_akg_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_sl26da_c" stoichiometry="1" constant="true"/>
@@ -5032,8 +33473,35 @@
           <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_sl2a6o_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_SERAT" name="R_SERAT" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3359"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_SERAT" sboTerm="SBO:0000176" id="R_SERAT" name="Serine O-acetyltransferase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_SERAT">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/SERAT"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:SERINE-O-ACETTRAN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.1.30"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00586"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104275"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MTU-936615"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24560"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24563"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24562"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24561"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/986"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00423"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-5.613569691163775"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-3.6637359812630166e-15"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_accoa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ser__L_c" stoichiometry="1" constant="true"/>
@@ -5042,8 +33510,33 @@
           <speciesReference species="M_acser_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_SHCHD2" name="R_SHCHD2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3607"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_SHCHD2" sboTerm="SBO:0000176" id="R_SHCHD2" name="Sirohydrochlorin dehydrogenase (NAD)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_SHCHD2">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/SHCHD2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:DIMETHUROPORDEHYDROG-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.1.76"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R03947"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104373"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15613"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15614"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15615"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15616"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn02774"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/2429.7987341560092"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/13.45689748863328"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_dscl_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
@@ -5053,8 +33546,31 @@
           <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_scl_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_SHCHF" name="R_SHCHF" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3368"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_SHCHF" sboTerm="SBO:0000176" id="R_SHCHF" name="Sirohydrochlorin ferrochelatase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_SHCHF">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/SHCHF"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:SIROHEME-FERROCHELAT-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.99.1.4"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R02864"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104375"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24360"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24361"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24362"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24363"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn02056"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_fe2_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_scl_c" stoichiometry="1" constant="true"/>
@@ -5063,8 +33579,36 @@
           <speciesReference species="M_h_c" stoichiometry="3" constant="true"/>
           <speciesReference species="M_sheme_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_SHK3Dr" name="R_SHK3Dr" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3368"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_SHK3Dr" sboTerm="SBO:0000176" id="R_SHK3Dr" name="Shikimate dehydrogenase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_SHK3Dr">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/SHK3Dr"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:SHIKIMATE-5-DEHYDROGENASE-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.25"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.282"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R02413"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104378"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MTU-964842"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17739"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17738"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17737"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17740"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/2351"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01740"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-9.153709738728367"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-1.3322676295501878e-15"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_3dhsk_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
@@ -5074,8 +33618,38 @@
           <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_skm_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_SHKK" name="R_SHKK" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b1692"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b3281"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_SHKK" sboTerm="SBO:0000176" id="R_SHKK" name="Shikimate kinase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_SHKK">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/SHKK"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:SHIKIMATE-KINASE-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.1.71"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R02412"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104379"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MTU-964939"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13121"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13122"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13123"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13124"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/2350"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01739"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-22.426709562109238"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.020989694878274623"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_skm_c" stoichiometry="1" constant="true"/>
@@ -5085,8 +33659,36 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_skm5p_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_SHSL1" name="R_SHSL1" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b3390"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0388"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_SHSL1" sboTerm="SBO:0000176" id="R_SHSL1" name="O-succinylhomoserine lyase (L-cysteine)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_SHSL1">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/SHSL1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:O-SUCCHOMOSERLYASE-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.5.1.48"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R03260"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104380"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/20398"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/20399"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/20400"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/20397"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/3081"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-61.80177644452982"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.0796399516107796"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_cys__L_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_suchms_c" stoichiometry="1" constant="true"/>
@@ -5096,8 +33698,29 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_succ_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_SO4t2pp" name="R_SO4t2pp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3939"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_SO4t2pp" sboTerm="SBO:0000185" id="R_SO4t2pp" name="Sulfate transport in via proton symport (periplasm to cytoplasm)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_SO4t2pp">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/SO4t2pp"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104466"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28575"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28574"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28576"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28577"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn13116"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn05651"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h_p" stoichiometry="1" constant="true"/>
           <speciesReference species="M_so4_p" stoichiometry="1" constant="true"/>
@@ -5106,16 +33729,82 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_so4_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_SO4tex" name="R_SO4tex" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b1206"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_SO4tex" sboTerm="SBO:0000185" id="R_SO4tex" name="Sulfate transport via diffusion (extracellular to periplasm)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_SO4tex">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/SO4tex"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104469"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-8875871"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-8875871"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-8875871"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-8875871"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-8875871"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-8875871"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-8875871"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-8875871"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-8875871"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-8875871"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-8875871"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-8875871"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-8875871"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-8875871"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-8875871"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-8875871"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/34983"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/34984"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/34986"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/34985"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09261"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn05238"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_so4_e" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_so4_p" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_SUCCt2_2pp" name="R_SUCCt2_2pp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b0241"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0929"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b1377"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2215"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_SUCCt2_2pp" sboTerm="SBO:0000185" id="R_SUCCt2_2pp" name="Succinate transport via proton symport (2 H) (periplasm)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_SUCCt2_2pp">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/SUCCt2_2pp"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:TRANS-RXN-121"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104620"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29305"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29306"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29304"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29303"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn10154"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09269"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-5.683349509194247"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h_p" stoichiometry="2" constant="true"/>
           <speciesReference species="M_succ_p" stoichiometry="1" constant="true"/>
@@ -5124,8 +33813,26 @@
           <speciesReference species="M_h_c" stoichiometry="2" constant="true"/>
           <speciesReference species="M_succ_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_SUCCt3pp" name="R_SUCCt3pp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3528"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_SUCCt3pp" sboTerm="SBO:0000185" id="R_SUCCt3pp" name="Succinate transport out via proton antiport (periplasm)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_SUCCt3pp">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/SUCCt3pp"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104623"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09270"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-46.292319258166266"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_succ_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_p" stoichiometry="1" constant="true"/>
@@ -5135,15 +33842,59 @@
           <speciesReference species="M_succ_p" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction id="R_SUCCtex" name="R_SUCCtex" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+      <reaction metaid="meta_R_SUCCtex" sboTerm="SBO:0000185" id="R_SUCCtex" name="Succinate transport via diffusion (extracellular to periplasm)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_SUCCtex">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/SUCCtex"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:TRANS-RXN0-552"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104619"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn10952"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09271"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/28.9455"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_succ_e" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_succ_p" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_SUCDi" name="R_SUCDi" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b0241"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0929"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b1377"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2215"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_SUCDi" sboTerm="SBO:0000176" id="R_SUCDi" name="Succinate dehydrogenase (irreversible)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_SUCDi">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/SUCDi"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR99641"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29190"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29189"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29187"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29188"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09272"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-73.53783450861198"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.13132380242200892"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_q8_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_succ_c" stoichiometry="1" constant="true"/>
@@ -5152,8 +33903,57 @@
           <speciesReference species="M_fum_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_q8h2_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_SUCOAS" name="R_SUCOAS" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:and>
+            <fbc:geneProductRef fbc:geneProduct="G_b0721"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0722"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0723"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0724"/>
+          </fbc:and>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_SUCOAS" sboTerm="SBO:0000176" id="R_SUCOAS" name="Succinyl-CoA synthetase (ADP-forming)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_SUCOAS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/SUCOAS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:SUCCCOASYN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/6.2.1.5"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00405"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104635"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-70997"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-372977"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-70997"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-373134"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-70997"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-70997"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-70997"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-70997"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-70997"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-70997"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-70997"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-70997"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-70997"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-70997"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-70997"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-70997"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-70997"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-70997"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17664"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17663"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17662"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17661"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/260"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00285"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-2.8799703209349445"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.00026187984807368725"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
@@ -5164,8 +33964,26 @@
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_succoa_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_SULRi" name="R_SULRi" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:and>
+            <fbc:geneProductRef fbc:geneProduct="G_b0728"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0729"/>
+          </fbc:and>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_SULRi" id="R_SULRi" name="R_SULRi" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_SULRi">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-119.74806036405016"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.0073726667983278205"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h_c" stoichiometry="5" constant="true"/>
           <speciesReference species="M_nadph_c" stoichiometry="3" constant="true"/>
@@ -5177,7 +33995,28 @@
           <speciesReference species="M_nadp_c" stoichiometry="3" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction id="R_TALA" name="R_TALA" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+      <reaction metaid="meta_R_TALA" sboTerm="SBO:0000176" id="R_TALA" name="Transaldolase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_TALA">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/TALA"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:TRANSALDOL-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.2.1.2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01827"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104715"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17056"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17055"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17054"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17053"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/3.478692686534714"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.025319283339884334"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_g3p_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_s7p_c" stoichiometry="1" constant="true"/>
@@ -5186,8 +34025,36 @@
           <speciesReference species="M_e4p_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_f6p_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_TDSK" name="R_TDSK" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b2464"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0008"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_TDSK" sboTerm="SBO:0000176" id="R_TDSK" name="Tetraacyldisaccharide 4&apos;kinase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_TDSK">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/TDSK"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:TETRAACYLDISACC4KIN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.1.130"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R04657"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104762"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/20702"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/20701"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/20703"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/20700"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn03181"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-7.848424089190303"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.14827179623172437"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_lipidAds_c" stoichiometry="1" constant="true"/>
@@ -5197,8 +34064,28 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_lipidA_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_THD2pp" name="R_THD2pp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0915"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_THD2pp" sboTerm="SBO:0000185" id="R_THD2pp" name="NAD(P) transhydrogenase (periplasm)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_THD2pp">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/THD2pp"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.6.1.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104805"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn10125"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09295"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-35.10954537950019"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.33576292404529656"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
@@ -5209,8 +34096,36 @@
           <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_THDPS" name="R_THDPS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:and>
+            <fbc:geneProductRef fbc:geneProduct="G_b1602"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b1603"/>
+          </fbc:and>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_THDPS" sboTerm="SBO:0000176" id="R_THDPS" name="Tetrahydrodipicolinate succinylase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_THDPS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/THDPS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:TETHYDPICSUCC-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.1.117"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R04365"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104806"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17325"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17327"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17326"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17328"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn03031"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/26.29096897214015"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/1.14239441931389"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_succoa_c" stoichiometry="1" constant="true"/>
@@ -5220,8 +34135,34 @@
           <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_sl2a6o_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_THRD_L" name="R_THRD_L" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0166"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_THRD_L" sboTerm="SBO:0000176" id="R_THRD_L" name="L-threonine deaminase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_THRD_L">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/THRD_L"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:THREDEHYD-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.3.1.19"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00996"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104714"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22108"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22111"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22109"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22110"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/1290"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00737"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-24.096384742715912"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.006452053842961142"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_thr__L_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
@@ -5229,8 +34170,36 @@
           <speciesReference species="M_2obut_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nh4_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_THRS" name="R_THRS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b3117"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b3772"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_THRS" sboTerm="SBO:0000176" id="R_THRS" name="Threonine synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_THRS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/THRS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:THRESYN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.2.3.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01466"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104846"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10842"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10841"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10840"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10843"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01069"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-30.06140786671034"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.03011683304728574"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_phom_c" stoichiometry="1" constant="true"/>
@@ -5239,8 +34208,23 @@
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_thr__L_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_THZPSN3" name="R_THZPSN3" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0004"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_THZPSN3" sboTerm="SBO:0000176" id="R_THZPSN3" name="Thiazole phosphate synthesis" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_THZPSN3">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/THZPSN3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104861"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_dhgly_c" stoichiometry="1" constant="true"/>
@@ -5258,8 +34242,32 @@
           <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_TKT1" name="R_TKT1" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:and>
+            <fbc:geneProductRef fbc:geneProduct="G_b2530"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b3992"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b3990"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0423"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b4407"/>
+          </fbc:and>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_TKT1" sboTerm="SBO:0000176" id="R_TKT1" name="Transketolase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_TKT1">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/TKT1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.2.1.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104868"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-1.5377969624681782"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.10129091190800386"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_r5p_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_xu5p__D_c" stoichiometry="1" constant="true"/>
@@ -5268,8 +34276,35 @@
           <speciesReference species="M_g3p_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_s7p_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_TKT2" name="R_TKT2" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b2935"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2465"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_TKT2" sboTerm="SBO:0000176" id="R_TKT2" name="Transketolase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_TKT2">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/TKT2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:2TRANSKETO-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.2.1.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01830"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104869"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27627"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27628"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27626"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27629"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-5.825573193874902"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.02481294096656982"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_e4p_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_xu5p__D_c" stoichiometry="1" constant="true"/>
@@ -5278,8 +34313,34 @@
           <speciesReference species="M_f6p_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_g3p_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_TMDS" name="R_TMDS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b2935"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2465"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_TMDS" sboTerm="SBO:0000176" id="R_TMDS" name="Thymidylate synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_TMDS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/TMDS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.1.1.45"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R02101"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104889"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12106"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12104"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12107"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12105"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-45.12282566688532"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.31504462781997716"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_dump_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_mlthf_c" stoichiometry="1" constant="true"/>
@@ -5288,8 +34349,34 @@
           <speciesReference species="M_dhf_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_dtmp_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_TMPK" name="R_TMPK" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b2827"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_TMPK" sboTerm="SBO:0000176" id="R_TMPK" name="Thiamine-phosphate kinase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_TMPK">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/TMPK"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:THI-P-KIN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.4.16"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00617"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104907"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15913"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15916"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15915"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15914"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/1007"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00438"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-45.78480412025658"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.030612385764556604"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_thmmp_c" stoichiometry="1" constant="true"/>
@@ -5298,8 +34385,34 @@
           <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_thmpp_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_TMPPP" name="R_TMPPP" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0417"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_TMPPP" sboTerm="SBO:0000176" id="R_TMPPP" name="Thiamine-phosphate diphosphorylase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_TMPPP">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/TMPPP"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:THI-P-SYN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.5.1.3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R03223"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104908"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22328"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22329"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22331"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22330"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/3049"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn02305"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-31.022892170572504"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-2.2870594307278225e-14"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_2mahmp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_4mpetz_c" stoichiometry="1" constant="true"/>
@@ -5309,16 +34422,104 @@
           <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_thmmp_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_TPI" name="R_TPI" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3993"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_TPI" sboTerm="SBO:0000176" id="R_TPI" name="Triose-phosphate isomerase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_TPI">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/TPI"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:TRIOSEPISOMERIZATION-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/5.3.1.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01015"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104918"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-70481"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-70481"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-70481"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-70481"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-352927"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-70454"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-70481"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-70454"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-70454"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-70481"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-70454"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-352914"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-70481"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-70454"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-70454"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-70481"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-70454"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-70481"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-70481"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-70481"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-70454"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-70454"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-70454"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-70454"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-70481"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-70481"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-70481"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-70481"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-70454"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-70481"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-70454"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-70454"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-70454"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-70481"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-70454"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-70454"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18587"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18588"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18586"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18585"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/4"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00747"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/5.661312081930191"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.00172377362515049"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_dhap_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_g3p_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_TRPAS2" name="R_TRPAS2" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3919"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_TRPAS2" sboTerm="SBO:0000176" id="R_TRPAS2" name="Tryptophanase (L-tryptophan)" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_TRPAS2">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/TRPAS2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:TRYPTOPHAN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.1.99.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00673"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104941"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/19556"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/19553"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/19555"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/19554"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/1053"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00473"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/20.181306076851726"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.00011235047847875336"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_trp__L_c" stoichiometry="1" constant="true"/>
@@ -5328,8 +34529,34 @@
           <speciesReference species="M_nh4_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_TRPS3" name="R_TRPS3" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3708"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_TRPS3" sboTerm="SBO:0000176" id="R_TRPS3" name="Tryptophan synthase (indoleglycerol phosphate)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_TRPS3">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/TRPS3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN0-2381"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.1.2.8"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.2.1.20"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R02340"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR99889"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14082"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14081"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14083"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14084"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01682"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/19.194289061288373"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/1.5469396597023177e-15"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_3ig3p_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
@@ -5337,8 +34564,37 @@
           <speciesReference species="M_g3p_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_indole_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_TRSARr" name="R_TRSARr" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:and>
+            <fbc:geneProductRef fbc:geneProduct="G_b1260"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b1261"/>
+          </fbc:and>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_TRSARr" sboTerm="SBO:0000176" id="R_TRSARr" name="Tartronate semialdehyde reductase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_TRSARr">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/TRSARr"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN0-5289"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.60"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01745"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100682"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18846"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18845"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18847"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18848"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01280"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-32.99587024204857"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/6.217248937900877e-15"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_2h3oppan_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
@@ -5348,8 +34604,32 @@
           <speciesReference species="M_glyc__R_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_TYRL" name="R_TYRL" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b0509"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b3125"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_TYRL" sboTerm="SBO:0000176" id="R_TYRL" name="Tyrosine lyase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_TYRL">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/TYRL"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN-11319"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.1.99.19"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104993"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/26361"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/26363"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/26362"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/26364"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_amet_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
@@ -5363,8 +34643,69 @@
           <speciesReference species="M_met__L_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_TYRTA" name="R_TYRTA" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3991"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_TYRTA" sboTerm="SBO:0000176" id="R_TYRTA" name="Tyrosine transaminase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_TYRTA">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/TYRTA"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:TYROSINE-AMINOTRANSFERASE-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.6.1.57"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.6.1.5"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.6.1.9"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.6.1.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00734"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR105000"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-517444"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-517444"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-71155"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-517444"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-517444"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-517444"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-517444"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-71155"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-517444"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-71155"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-71155"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-71155"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-71155"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-71155"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-517444"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-517444"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-71155"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-517444"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-517444"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-71155"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-517444"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-71155"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-517444"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-517444"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-517444"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-517444"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-71155"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-71155"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-71155"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-71155"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-71155"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-71155"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15094"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15096"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15093"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15095"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/1097"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00527"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/0.48794889823824406"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/2.409097227262791e-15"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_akg_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_tyr__L_c" stoichiometry="1" constant="true"/>
@@ -5373,8 +34714,30 @@
           <speciesReference species="M_34hpp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_U23GAAT" name="R_U23GAAT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b4054"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0928"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_U23GAAT" sboTerm="SBO:0000176" id="R_U23GAAT" name="UDP-3-O-(3-hydroxymyristoyl)glucosamine acyltransferase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_U23GAAT">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/U23GAAT"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:UDPHYDROXYMYRGLUCOSAMNACETYLTRANS-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.1.191"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R04550"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR105007"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn06723"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_3hmrsACP_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_u3hga_c" stoichiometry="1" constant="true"/>
@@ -5384,8 +34747,26 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_u23ga_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_UAAGDS" name="R_UAAGDS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0179"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_UAAGDS" sboTerm="SBO:0000176" id="R_UAAGDS" name="UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate synthetase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_UAAGDS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/UAAGDS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/6.3.2.13"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR105013"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-24.197447238530913"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.08630952804611905"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_26dap__M_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
@@ -5397,8 +34778,27 @@
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ugmd_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_UAGAAT" name="R_UAGAAT" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0085"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_UAGAAT" sboTerm="SBO:0000176" id="R_UAGAAT" name="UDP-N-acetylglucosamine acyltransferase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_UAGAAT">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/UAGAAT"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:UDPNACETYLGLUCOSAMACYLTRANS-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.1.129"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R04567"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR105028"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn06729"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_3hmrsACP_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_uacgam_c" stoichiometry="1" constant="true"/>
@@ -5407,8 +34807,36 @@
           <speciesReference species="M_ACP_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_u3aga_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_UAGCVT" name="R_UAGCVT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:and>
+            <fbc:geneProductRef fbc:geneProduct="G_b1094"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0181"/>
+          </fbc:and>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_UAGCVT" sboTerm="SBO:0000176" id="R_UAGCVT" name="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_UAGCVT">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/UAGCVT"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:UDPNACETYLGLUCOSAMENOLPYRTRANS-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.5.1.7"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00660"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR105032"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18681"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18682"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18683"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18684"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00461"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-14.627660336154804"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.059845743968766185"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_pep_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_uacgam_c" stoichiometry="1" constant="true"/>
@@ -5417,8 +34845,46 @@
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_uaccg_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_UAGDP" name="R_UAGDP" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3189"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_UAGDP" sboTerm="SBO:0000176" id="R_UAGDP" name="UDP-N-acetylglucosamine diphosphorylase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_UAGDP">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/UAGDP"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.7.23"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR105033"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-446204"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-446204"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-446204"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-446204"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-446204"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-446204"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-446204"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-446204"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-446204"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-446204"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-446204"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-446204"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-446204"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-446204"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-446204"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-446204"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-446204"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-446204"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/870"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00293"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-14.107549950476255"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.055227404535843"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_acgam1p_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
@@ -5428,8 +34894,34 @@
           <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_uacgam_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_UAGPT3" name="R_UAGPT3" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3730"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_UAGPT3" sboTerm="SBO:0000176" id="R_UAGPT3" name="UDP-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_UAGPT3">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/UAGPT3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:NACGLCTRANS-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.4.1.227"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R05032"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R06174"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR139325"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/31228"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/31227"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/31229"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/31230"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn03408"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-13.463733075699395"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.018798467043312617"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_uacgam_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_uagmda_c" stoichiometry="1" constant="true"/>
@@ -5439,8 +34931,35 @@
           <speciesReference species="M_uaagmda_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_udp_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_UAMAGS" name="R_UAMAGS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0090"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_UAMAGS" sboTerm="SBO:0000176" id="R_UAMAGS" name="UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_UAMAGS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/UAMAGS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:UDP-NACMURALA-GLU-LIG-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/6.3.2.9"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R02783"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR105038"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16430"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16429"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16431"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16432"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/2659"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn02008"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn11252"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-29.786045799897238"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.012460148748438427"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_glu__D_c" stoichiometry="1" constant="true"/>
@@ -5452,8 +34971,34 @@
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_uamag_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_UAMAS" name="R_UAMAS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0088"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_UAMAS" sboTerm="SBO:0000176" id="R_UAMAS" name="UDP-N-acetylmuramoyl-L-alanine synthetase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_UAMAS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/UAMAS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:UDP-NACMUR-ALA-LIG-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/6.3.2.8"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R03193"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR141024"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23372"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23374"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23373"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23375"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn11251"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn02286"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-27.633673279823142"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.10844678445307618"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_ala__L_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
@@ -5465,8 +35010,34 @@
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_uama_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_UAPGR" name="R_UAPGR" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0091"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_UAPGR" sboTerm="SBO:0000176" id="R_UAPGR" name="UDP-N-acetylenolpyruvoylglucosamine reductase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_UAPGR">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/UAPGR"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:UDPNACETYLMURAMATEDEHYDROG-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.1.98"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R03192"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR141027"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12251"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12250"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12248"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12249"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/3021"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn02285"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-58.05519041523121"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.04765628505119146"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
@@ -5476,8 +35047,30 @@
           <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_uamr_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_UDCPDP" name="R_UDCPDP" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3972"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_UDCPDP" sboTerm="SBO:0000176" id="R_UDCPDP" name="Undecaprenyl-diphosphatase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_UDCPDP">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/UDCPDP"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR105042"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17069"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17070"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17072"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17071"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/5225"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-32.17599348337069"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.08814249337937463"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_udcpdp_c" stoichiometry="1" constant="true"/>
@@ -5487,8 +35080,34 @@
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_udcpp_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_UDCPDPS" name="R_UDCPDPS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b0841"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b1278"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b3057"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_UDCPDPS" sboTerm="SBO:0000176" id="R_UDCPDPS" name="Undecaprenyl diphosphate synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_UDCPDPS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/UDCPDPS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN-9138"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.5.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.5.1.M1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.5.1.31"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR105043"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/12133"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-645.9325802408697"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/1.4837497112584845"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_frdp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ipdp_c" stoichiometry="8" constant="true"/>
@@ -5497,8 +35116,27 @@
           <speciesReference species="M_ppi_c" stoichiometry="8" constant="true"/>
           <speciesReference species="M_udcpdp_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_UGMDDS" name="R_UGMDDS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0174"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_UGMDDS" sboTerm="SBO:0000176" id="R_UGMDDS" name="UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine synthetase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_UGMDDS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/UGMDDS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/6.3.2.10"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR105094"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/4284"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-30.0488182826939"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.08630952804612829"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_alaala_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
@@ -5510,8 +35148,33 @@
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ugmda_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_UHGADA" name="R_UHGADA" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0086"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_UHGADA" sboTerm="SBO:0000176" id="R_UHGADA" name="UDP-3-O-acetylglucosamine deacetylase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_UHGADA">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/UHGADA"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:UDPACYLGLCNACDEACETYL-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.5.1.108"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R04587"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR105110"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/25212"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/25209"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/25211"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/25210"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn03146"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-6.106158681731586"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.12227280772041371"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_u3aga_c" stoichiometry="1" constant="true"/>
@@ -5520,8 +35183,36 @@
           <speciesReference species="M_ac_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_u3hga_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_UMPK" name="R_UMPK" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0096"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_UMPK" sboTerm="SBO:0000176" id="R_UMPK" name="UMP kinase" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_UMPK">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/UMPK"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN-12002"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.4.4"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.4.22"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.4.14"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00158"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR105118"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24400"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24402"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24401"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/24403"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/201"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00119"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-0.7444216403580981"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.00035632237831406677"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_ump_c" stoichiometry="1" constant="true"/>
@@ -5530,8 +35221,36 @@
           <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_udp_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_UPP3MT" name="R_UPP3MT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b0910"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0171"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_UPP3MT" sboTerm="SBO:0000176" id="R_UPP3MT" name="Uroporphyrinogen methyltransferase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_UPP3MT">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/UPP3MT"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN-13403"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.1.1.107"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R03194"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR105137"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/32462"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/32461"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/32459"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/32460"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn02287"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-263.16856350994044"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/9.24372561557499"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_amet_c" stoichiometry="2" constant="true"/>
           <speciesReference species="M_uppg3_c" stoichiometry="1" constant="true"/>
@@ -5541,8 +35260,50 @@
           <speciesReference species="M_dscl_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-      </reaction>
-      <reaction id="R_UPP3S" name="R_UPP3S" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b3803"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b3368"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="meta_R_UPP3S" sboTerm="SBO:0000176" id="R_UPP3S" name="Uroporphyrinogen-III synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_UPP3S">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/UPP3S"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:UROGENIIISYN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.2.1.75"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R03165"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR105139"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-189488"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-189488"/>
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         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_zn2_p" stoichiometry="1" constant="true"/>
         </listOfProducts>
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+            <fbc:geneProductRef fbc:geneProduct="G_b0929"/>
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+            <fbc:geneProductRef fbc:geneProduct="G_b2215"/>
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       </reaction>
     </listOfReactions>
     <fbc:listOfObjectives fbc:activeObjective="obj">
@@ -5616,5 +35803,512 @@
         </fbc:listOfFluxObjectives>
       </fbc:objective>
     </fbc:listOfObjectives>
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+      <fbc:geneProduct fbc:id="G_b2564" fbc:name="G_b2564" fbc:label="G_b2564"/>
+      <fbc:geneProduct fbc:id="G_b0052" fbc:name="G_b0052" fbc:label="G_b0052"/>
+      <fbc:geneProduct fbc:id="G_b2320" fbc:name="G_b2320" fbc:label="G_b2320"/>
+      <fbc:geneProduct fbc:id="G_b1723" fbc:name="G_b1723" fbc:label="G_b1723"/>
+      <fbc:geneProduct fbc:id="G_b3916" fbc:name="G_b3916" fbc:label="G_b3916"/>
+      <fbc:geneProduct fbc:id="G_b2579" fbc:name="G_b2579" fbc:label="G_b2579"/>
+      <fbc:geneProduct fbc:id="G_b0903" fbc:name="G_b0903" fbc:label="G_b0903"/>
+      <fbc:geneProduct fbc:id="G_b3951" fbc:name="G_b3951" fbc:label="G_b3951"/>
+      <fbc:geneProduct fbc:id="G_b0902" fbc:name="G_b0902" fbc:label="G_b0902"/>
+      <fbc:geneProduct fbc:id="G_b3952" fbc:name="G_b3952" fbc:label="G_b3952"/>
+      <fbc:geneProduct fbc:id="G_b3114" fbc:name="G_b3114" fbc:label="G_b3114"/>
+      <fbc:geneProduct fbc:id="G_b3176" fbc:name="G_b3176" fbc:label="G_b3176"/>
+      <fbc:geneProduct fbc:id="G_b2913" fbc:name="G_b2913" fbc:label="G_b2913"/>
+      <fbc:geneProduct fbc:id="G_b4025" fbc:name="G_b4025" fbc:label="G_b4025"/>
+      <fbc:geneProduct fbc:id="G_b2926" fbc:name="G_b2926" fbc:label="G_b2926"/>
+      <fbc:geneProduct fbc:id="G_b0767" fbc:name="G_b0767" fbc:label="G_b0767"/>
+      <fbc:geneProduct fbc:id="G_b3612" fbc:name="G_b3612" fbc:label="G_b3612"/>
+      <fbc:geneProduct fbc:id="G_b0755" fbc:name="G_b0755" fbc:label="G_b0755"/>
+      <fbc:geneProduct fbc:id="G_b4395" fbc:name="G_b4395" fbc:label="G_b4395"/>
+      <fbc:geneProduct fbc:id="G_b2987" fbc:name="G_b2987" fbc:label="G_b2987"/>
+      <fbc:geneProduct fbc:id="G_b3493" fbc:name="G_b3493" fbc:label="G_b3493"/>
+      <fbc:geneProduct fbc:id="G_b3412" fbc:name="G_b3412" fbc:label="G_b3412"/>
+      <fbc:geneProduct fbc:id="G_b2103" fbc:name="G_b2103" fbc:label="G_b2103"/>
+      <fbc:geneProduct fbc:id="G_b3974" fbc:name="G_b3974" fbc:label="G_b3974"/>
+      <fbc:geneProduct fbc:id="G_b0871" fbc:name="G_b0871" fbc:label="G_b0871"/>
+      <fbc:geneProduct fbc:id="G_b0369" fbc:name="G_b0369" fbc:label="G_b0369"/>
+      <fbc:geneProduct fbc:id="G_b3956" fbc:name="G_b3956" fbc:label="G_b3956"/>
+      <fbc:geneProduct fbc:id="G_b3639" fbc:name="G_b3639" fbc:label="G_b3639"/>
+      <fbc:geneProduct fbc:id="G_b3403" fbc:name="G_b3403" fbc:label="G_b3403"/>
+      <fbc:geneProduct fbc:id="G_b3380" fbc:name="G_b3380" fbc:label="G_b3380"/>
+      <fbc:geneProduct fbc:id="G_b4383" fbc:name="G_b4383" fbc:label="G_b4383"/>
+      <fbc:geneProduct fbc:id="G_b3850" fbc:name="G_b3850" fbc:label="G_b3850"/>
+      <fbc:geneProduct fbc:id="G_b1702" fbc:name="G_b1702" fbc:label="G_b1702"/>
+      <fbc:geneProduct fbc:id="G_b4005" fbc:name="G_b4005" fbc:label="G_b4005"/>
+      <fbc:geneProduct fbc:id="G_b2499" fbc:name="G_b2499" fbc:label="G_b2499"/>
+      <fbc:geneProduct fbc:id="G_b2026" fbc:name="G_b2026" fbc:label="G_b2026"/>
+      <fbc:geneProduct fbc:id="G_b2476" fbc:name="G_b2476" fbc:label="G_b2476"/>
+      <fbc:geneProduct fbc:id="G_b2557" fbc:name="G_b2557" fbc:label="G_b2557"/>
+      <fbc:geneProduct fbc:id="G_b2024" fbc:name="G_b2024" fbc:label="G_b2024"/>
+      <fbc:geneProduct fbc:id="G_b4111" fbc:name="G_b4111" fbc:label="G_b4111"/>
+      <fbc:geneProduct fbc:id="G_b1015" fbc:name="G_b1015" fbc:label="G_b1015"/>
+      <fbc:geneProduct fbc:id="G_b1207" fbc:name="G_b1207" fbc:label="G_b1207"/>
+      <fbc:geneProduct fbc:id="G_b0908" fbc:name="G_b0908" fbc:label="G_b0908"/>
+      <fbc:geneProduct fbc:id="G_b4160" fbc:name="G_b4160" fbc:label="G_b4160"/>
+      <fbc:geneProduct fbc:id="G_b4388" fbc:name="G_b4388" fbc:label="G_b4388"/>
+      <fbc:geneProduct fbc:id="G_b2585" fbc:name="G_b2585" fbc:label="G_b2585"/>
+      <fbc:geneProduct fbc:id="G_b2297" fbc:name="G_b2297" fbc:label="G_b2297"/>
+      <fbc:geneProduct fbc:id="G_b2458" fbc:name="G_b2458" fbc:label="G_b2458"/>
+      <fbc:geneProduct fbc:id="G_b3634" fbc:name="G_b3634" fbc:label="G_b3634"/>
+      <fbc:geneProduct fbc:id="G_b1676" fbc:name="G_b1676" fbc:label="G_b1676"/>
+      <fbc:geneProduct fbc:id="G_b1854" fbc:name="G_b1854" fbc:label="G_b1854"/>
+      <fbc:geneProduct fbc:id="G_b3831" fbc:name="G_b3831" fbc:label="G_b3831"/>
+      <fbc:geneProduct fbc:id="G_b0750" fbc:name="G_b0750" fbc:label="G_b0750"/>
+      <fbc:geneProduct fbc:id="G_b1662" fbc:name="G_b1662" fbc:label="G_b1662"/>
+      <fbc:geneProduct fbc:id="G_b0415" fbc:name="G_b0415" fbc:label="G_b0415"/>
+      <fbc:geneProduct fbc:id="G_b2687" fbc:name="G_b2687" fbc:label="G_b2687"/>
+      <fbc:geneProduct fbc:id="G_b4238" fbc:name="G_b4238" fbc:label="G_b4238"/>
+      <fbc:geneProduct fbc:id="G_b4237" fbc:name="G_b4237" fbc:label="G_b4237"/>
+      <fbc:geneProduct fbc:id="G_b4301" fbc:name="G_b4301" fbc:label="G_b4301"/>
+      <fbc:geneProduct fbc:id="G_b3386" fbc:name="G_b3386" fbc:label="G_b3386"/>
+      <fbc:geneProduct fbc:id="G_b4090" fbc:name="G_b4090" fbc:label="G_b4090"/>
+      <fbc:geneProduct fbc:id="G_b2914" fbc:name="G_b2914" fbc:label="G_b2914"/>
+      <fbc:geneProduct fbc:id="G_b2751" fbc:name="G_b2751" fbc:label="G_b2751"/>
+      <fbc:geneProduct fbc:id="G_b2752" fbc:name="G_b2752" fbc:label="G_b2752"/>
+      <fbc:geneProduct fbc:id="G_b2472" fbc:name="G_b2472" fbc:label="G_b2472"/>
+      <fbc:geneProduct fbc:id="G_b3607" fbc:name="G_b3607" fbc:label="G_b3607"/>
+      <fbc:geneProduct fbc:id="G_b3368" fbc:name="G_b3368" fbc:label="G_b3368"/>
+      <fbc:geneProduct fbc:id="G_b3281" fbc:name="G_b3281" fbc:label="G_b3281"/>
+      <fbc:geneProduct fbc:id="G_b1692" fbc:name="G_b1692" fbc:label="G_b1692"/>
+      <fbc:geneProduct fbc:id="G_b0388" fbc:name="G_b0388" fbc:label="G_b0388"/>
+      <fbc:geneProduct fbc:id="G_b3390" fbc:name="G_b3390" fbc:label="G_b3390"/>
+      <fbc:geneProduct fbc:id="G_b3939" fbc:name="G_b3939" fbc:label="G_b3939"/>
+      <fbc:geneProduct fbc:id="G_b1206" fbc:name="G_b1206" fbc:label="G_b1206"/>
+      <fbc:geneProduct fbc:id="G_b3528" fbc:name="G_b3528" fbc:label="G_b3528"/>
+      <fbc:geneProduct fbc:id="G_b0721" fbc:name="G_b0721" fbc:label="G_b0721"/>
+      <fbc:geneProduct fbc:id="G_b0724" fbc:name="G_b0724" fbc:label="G_b0724"/>
+      <fbc:geneProduct fbc:id="G_b0722" fbc:name="G_b0722" fbc:label="G_b0722"/>
+      <fbc:geneProduct fbc:id="G_b0723" fbc:name="G_b0723" fbc:label="G_b0723"/>
+      <fbc:geneProduct fbc:id="G_b0728" fbc:name="G_b0728" fbc:label="G_b0728"/>
+      <fbc:geneProduct fbc:id="G_b0729" fbc:name="G_b0729" fbc:label="G_b0729"/>
+      <fbc:geneProduct fbc:id="G_b0008" fbc:name="G_b0008" fbc:label="G_b0008"/>
+      <fbc:geneProduct fbc:id="G_b2464" fbc:name="G_b2464" fbc:label="G_b2464"/>
+      <fbc:geneProduct fbc:id="G_b0915" fbc:name="G_b0915" fbc:label="G_b0915"/>
+      <fbc:geneProduct fbc:id="G_b0166" fbc:name="G_b0166" fbc:label="G_b0166"/>
+      <fbc:geneProduct fbc:id="G_b3117" fbc:name="G_b3117" fbc:label="G_b3117"/>
+      <fbc:geneProduct fbc:id="G_b3772" fbc:name="G_b3772" fbc:label="G_b3772"/>
+      <fbc:geneProduct fbc:id="G_b0004" fbc:name="G_b0004" fbc:label="G_b0004"/>
+      <fbc:geneProduct fbc:id="G_b4407" fbc:name="G_b4407" fbc:label="G_b4407"/>
+      <fbc:geneProduct fbc:id="G_b3990" fbc:name="G_b3990" fbc:label="G_b3990"/>
+      <fbc:geneProduct fbc:id="G_b0423" fbc:name="G_b0423" fbc:label="G_b0423"/>
+      <fbc:geneProduct fbc:id="G_b3992" fbc:name="G_b3992" fbc:label="G_b3992"/>
+      <fbc:geneProduct fbc:id="G_b2465" fbc:name="G_b2465" fbc:label="G_b2465"/>
+      <fbc:geneProduct fbc:id="G_b2935" fbc:name="G_b2935" fbc:label="G_b2935"/>
+      <fbc:geneProduct fbc:id="G_b2827" fbc:name="G_b2827" fbc:label="G_b2827"/>
+      <fbc:geneProduct fbc:id="G_b0417" fbc:name="G_b0417" fbc:label="G_b0417"/>
+      <fbc:geneProduct fbc:id="G_b3993" fbc:name="G_b3993" fbc:label="G_b3993"/>
+      <fbc:geneProduct fbc:id="G_b3919" fbc:name="G_b3919" fbc:label="G_b3919"/>
+      <fbc:geneProduct fbc:id="G_b3708" fbc:name="G_b3708" fbc:label="G_b3708"/>
+      <fbc:geneProduct fbc:id="G_b1261" fbc:name="G_b1261" fbc:label="G_b1261"/>
+      <fbc:geneProduct fbc:id="G_b1260" fbc:name="G_b1260" fbc:label="G_b1260"/>
+      <fbc:geneProduct fbc:id="G_b3125" fbc:name="G_b3125" fbc:label="G_b3125"/>
+      <fbc:geneProduct fbc:id="G_b0509" fbc:name="G_b0509" fbc:label="G_b0509"/>
+      <fbc:geneProduct fbc:id="G_b3991" fbc:name="G_b3991" fbc:label="G_b3991"/>
+      <fbc:geneProduct fbc:id="G_b0179" fbc:name="G_b0179" fbc:label="G_b0179"/>
+      <fbc:geneProduct fbc:id="G_b0085" fbc:name="G_b0085" fbc:label="G_b0085"/>
+      <fbc:geneProduct fbc:id="G_b0181" fbc:name="G_b0181" fbc:label="G_b0181"/>
+      <fbc:geneProduct fbc:id="G_b3189" fbc:name="G_b3189" fbc:label="G_b3189"/>
+      <fbc:geneProduct fbc:id="G_b0090" fbc:name="G_b0090" fbc:label="G_b0090"/>
+      <fbc:geneProduct fbc:id="G_b0088" fbc:name="G_b0088" fbc:label="G_b0088"/>
+      <fbc:geneProduct fbc:id="G_b0091" fbc:name="G_b0091" fbc:label="G_b0091"/>
+      <fbc:geneProduct fbc:id="G_b3972" fbc:name="G_b3972" fbc:label="G_b3972"/>
+      <fbc:geneProduct fbc:id="G_b3057" fbc:name="G_b3057" fbc:label="G_b3057"/>
+      <fbc:geneProduct fbc:id="G_b1278" fbc:name="G_b1278" fbc:label="G_b1278"/>
+      <fbc:geneProduct fbc:id="G_b0841" fbc:name="G_b0841" fbc:label="G_b0841"/>
+      <fbc:geneProduct fbc:id="G_b0174" fbc:name="G_b0174" fbc:label="G_b0174"/>
+      <fbc:geneProduct fbc:id="G_b0086" fbc:name="G_b0086" fbc:label="G_b0086"/>
+      <fbc:geneProduct fbc:id="G_b0096" fbc:name="G_b0096" fbc:label="G_b0096"/>
+      <fbc:geneProduct fbc:id="G_b0171" fbc:name="G_b0171" fbc:label="G_b0171"/>
+      <fbc:geneProduct fbc:id="G_b3803" fbc:name="G_b3803" fbc:label="G_b3803"/>
+      <fbc:geneProduct fbc:id="G_b3804" fbc:name="G_b3804" fbc:label="G_b3804"/>
+      <fbc:geneProduct fbc:id="G_b3997" fbc:name="G_b3997" fbc:label="G_b3997"/>
+      <fbc:geneProduct fbc:id="G_b0524" fbc:name="G_b0524" fbc:label="G_b0524"/>
+      <fbc:geneProduct fbc:id="G_b3572" fbc:name="G_b3572" fbc:label="G_b3572"/>
+    </fbc:listOfGeneProducts>
   </model>
 </sbml>
diff --git a/ECC2_old/box_positions.json b/ECC2_old/box_positions.json
new file mode 100644
index 0000000..b8e7cad
--- /dev/null
+++ b/ECC2_old/box_positions.json
@@ -0,0 +1,331 @@
+{
+    "Core Metabolism": {
+        "name": "Map",
+        "background": "map1.svg",
+        "bg-size": 1.9999999999999998,
+        "box-size": 1,
+        "zoom": -1,
+        "pos": [
+            508,
+            240
+        ],
+        "boxes": {
+            "EX_glc_e": [
+                136.1189089220017,
+                108.56067381889811
+            ],
+            "GLCptspp": [
+                420.51461380446653,
+                56.674879841782015
+            ],
+            "GLCt2pp": [
+                322.93124474092826,
+                127.92114270445839
+            ],
+            "HEX1": [
+                587.7503520284749,
+                116.09552362845176
+            ],
+            "G6PDH2r": [
+                849.9460237431543,
+                70.70107297778294
+            ],
+            "PGL": [
+                1039.2079551031634,
+                69.70107297778294
+            ],
+            "F6PA": [
+                496.70335268552014,
+                286.29771627774994
+            ],
+            "PGI": [
+                726.5038112782596,
+                176.63018887467717
+            ],
+            "GND": [
+                1157.8211997573917,
+                190.42833909156678
+            ],
+            "PFK": [
+                620.9167597600324,
+                309.92756228623927
+            ],
+            "FBP": [
+                736.2449507653714,
+                304.75653009690586
+            ],
+            "RPE": [
+                1093.5715881600554,
+                307.9845730160172
+            ],
+            "RPI": [
+                1196.1586396782825,
+                311.2126159351285
+            ],
+            "GLYCDx": [
+                373.9183133706874,
+                442.39596788713493
+            ],
+            "FBA": [
+                602.2896417324763,
+                385.37439920891
+            ],
+            "TKT2": [
+                821.2048842560425,
+                416.1417318320227
+            ],
+            "TKT1": [
+                1091.8566418089445,
+                389.7734743173548
+            ],
+            "TALA": [
+                1089.7996310791666,
+                486.01846145691513
+            ],
+            "TPI": [
+                583.5485022453645,
+                469.1633005102476
+            ],
+            "G3PD2": [
+                535.04003013514,
+                607.7457275706989
+            ],
+            "G3PD5": [
+                429.1941181040246,
+                604.4298563280329
+            ],
+            "GLYK": [
+                448.1633005102476,
+                709.0169078462601
+            ],
+            "EX_glyc_e": [
+                192.81836074850358,
+                764.1637474167575
+            ],
+            "PGK": [
+                732.9552726587062,
+                677.7626717911479
+            ],
+            "GAPD": [
+                733.8412511991506,
+                563.4344807858089
+            ],
+            "PGM": [
+                730.8982619289285,
+                788.8058091475978
+            ],
+            "ENO": [
+                734.1263048480398,
+                876.5947104489354
+            ],
+            "EDA": [
+                1246.8335195200648,
+                708.5870151440384
+            ],
+            "EDD": [
+                1354.721432687901,
+                138.47421735518074
+            ],
+            "EX_h_e": [
+                1687.1878658614603,
+                701.1252133988328
+            ],
+            "EX_h2o_e": [
+                1612.510542794775,
+                758.6828818762685
+            ],
+            "EX_co2_e": [
+                1606.5308450291814,
+                811.9809389407983
+            ],
+            "PPC": [
+                599.0948803299093,
+                927.0570022499734
+            ],
+            "PPCK": [
+                506.14056624779505,
+                1001.0351352707742
+            ],
+            "PYK": [
+                631.0472424525361,
+                1026.9140886178538
+            ],
+            "PPS": [
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+                1020.2553615974159
+            ],
+            "MGSA": [
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+                897.5927306580032
+            ],
+            "GLYOX3": [
+                1258.9953052313508,
+                1005.523225801431
+            ],
+            "LDH_D": [
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+                1032.81686090362
+            ],
+            "FHL": [
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+                1096.8922216386545
+            ],
+            "PFL": [
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+                1139.7473560470476
+            ],
+            "ME2": [
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+                1113.2830844550774
+            ],
+            "ME1": [
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+                1166.0409911492366
+            ],
+            "PDH": [
+                633.7793782485211,
+                1222.042943108724
+            ],
+            "POX": [
+                1044.451768985371,
+                1198.4080350269728
+            ],
+            "PTAr": [
+                898.1542299642072,
+                1278.459576823321
+            ],
+            "ACALD": [
+                959.4002271890231,
+                1326.9734382521517
+            ],
+            "ACKr": [
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+                1266.5568045375549
+            ],
+            "ALCD2x": [
+                1309.655984211276,
+                1327.8028017623706
+            ],
+            "EX_ac_e": [
+                1664.0290481732502,
+                1277.6806966287031
+            ],
+            "EX_etoh_e": [
+                1665.0290481732502,
+                1325.542356519551
+            ],
+            "CS": [
+                782.1930134607236,
+                1350.0609534428
+            ],
+            "EX_succ_e": [
+                128.19020030617904,
+                1959.8201513137842
+            ],
+            "SUCCt2_2pp": [
+                301.21626488913887,
+                1863.7306237058249
+            ],
+            "SUCDi": [
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+                1873.3994130363956
+            ],
+            "FRD2": [
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+                1862.5335257019117
+            ],
+            "FUM": [
+                397.3822001983073,
+                1706.9679574616653
+            ],
+            "MDH": [
+                401.9594584212965,
+                1542.1808164426823
+            ],
+            "MALS": [
+                599.9215196667201,
+                1597.0875113380907
+            ],
+            "SUCOAS": [
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+                1968.7808016317895
+            ],
+            "AKGDH": [
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+                1812.1370326967344
+            ],
+            "ICL": [
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+            ],
+            "ACONTa": [
+                969.1809238213577,
+                1446.7435158765807
+            ],
+            "ACONTb": [
+                1033.9535060512499,
+                1554.2682765559027
+            ],
+            "ICDHyr": [
+                1059.4442737250745,
+                1665.0019589962178
+            ],
+            "ADK1": [
+                1390.4140792041617,
+                1433.877628542097
+            ],
+            "ATPM": [
+                1332.1516988645008,
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diff --git a/ECC2_old/meta.json b/ECC2_old/meta.json
new file mode 100644
index 0000000..d35a35e
--- /dev/null
+++ b/ECC2_old/meta.json
@@ -0,0 +1 @@
+{"description": "EColiCore2\nMetabolic core model of Escherichia coli str. K-12 substr. MG1655, derived from iJO1366 with MATLAB CellNetAnalyzer function CNAreduceMFNetwork. Contains minor changes with respect to parent model iJO1366. No GPR-rules included.\n\nContains:\n686 metabolites\n500 reactions\n\nPublication:\nH\u00e4dicke, O., Klamt, S. EColiCore2: a reference network model of the central metabolism of Escherichia coli and relationships to its genome-scale parent model. Sci Rep 7, 39647 (2017). https://doi.org/10.1038/srep39647", "format version": 1}
\ No newline at end of file
diff --git a/ECC2_old/model.sbml b/ECC2_old/model.sbml
new file mode 100644
index 0000000..39c81ff
--- /dev/null
+++ b/ECC2_old/model.sbml
@@ -0,0 +1,5620 @@
+<?xml version="1.0" encoding="UTF-8"?>
+<sbml xmlns="http://www.sbml.org/sbml/level3/version1/core" xmlns:fbc="http://www.sbml.org/sbml/level3/version1/fbc/version2" metaid="meta_" sboTerm="SBO:0000624" level="3" version="1" fbc:required="false">
+  <model metaid="meta_CNA_EColiCore2" id="CNA_EColiCore2" name="EColiCore2 (ECC2)" fbc:strict="true">
+    <listOfUnitDefinitions>
+      <unitDefinition id="mmol_per_gDW_per_hr">
+        <listOfUnits>
+          <unit kind="mole" exponent="1" scale="-3" multiplier="1"/>
+          <unit kind="gram" exponent="-1" scale="0" multiplier="1"/>
+          <unit kind="second" exponent="-1" scale="0" multiplier="3600"/>
+        </listOfUnits>
+      </unitDefinition>
+    </listOfUnitDefinitions>
+    <listOfCompartments>
+      <compartment id="Internal_Species" constant="true"/>
+    </listOfCompartments>
+    <listOfSpecies>
+      <species id="M_10fthf_c" name="10-Formyltetrahydrofolate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_13dpg_c" name="3-Phospho-D-glyceroylphosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_1hdec9eg3p_c" name="1-hexadec-9-enoyl-sn-glycerol3-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_1hdecg3p_c" name="1-hexadecanoyl-sn-glycerol3-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_1pyr5c_c" name="1-Pyrroline-5-carboxylate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_23dhdp_c" name="2,3-Dihydrodipicolinate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_23dhmb_c" name="(R)-2,3-Dihydroxy-3-methylbutanoate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_23dhmp_c" name="(R)-2,3-Dihydroxy-3-methylpentanoate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_25aics_c" name="(S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_25drapp_c" name="2,5-Diamino-6-(ribosylamino)-4-(3H)-pyrimidinone5#-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_26dap__LL_c" name="LL-2,6-Diaminoheptanedioate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_26dap__M_c" name="meso-2,6-Diaminoheptanedioate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_2ahbut_c" name="(S)-2-Aceto-2-hydroxybutanoate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
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+      <species id="M_2dda7p_c" name="2-Dehydro-3-deoxy-D-arabino-heptonate7-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_2ddg6p_c" name="2-Dehydro-3-deoxy-D-gluconate6-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
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+      <species id="M_2dmmq8_c" name="2-Demethylmenaquinone8" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_2dmmql8_c" name="2-Demethylmenaquinol8" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_2dr1p_c" name="2-Deoxy-D-ribose1-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_2fe1s_c" name="[2Fe-1S]desulfuratediron-sulfurcluster" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_2fe2s_c" name="[2Fe-2S]iron-sulfurcluster" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_2h3oppan_c" name="2-Hydroxy-3-oxopropanoate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_2ippm_c" name="2-Isopropylmaleate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_2mahmp_c" name="2-Methyl-4-amino-5-hydroxymethylpyrimidinediphosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_2me4p_c" name="2-C-methyl-D-erythritol4-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_2mecdp_c" name="2-C-methyl-D-erythritol2,4-cyclodiphosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
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+      <species id="M_2ohph_c" name="2-Octaprenyl-6-hydroxyphenol" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_2oph_c" name="2-Octaprenylphenol" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
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+      <species id="M_3c4mop_c" name="3-Carboxy-4-methyl-2-oxopentanoate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_3dhq_c" name="3-Dehydroquinate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_3dhsk_c" name="3-Dehydroshikimate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_3hbcoa_c" name="(S)-3-Hydroxybutanoyl-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_3hdcoa_c" name="(S)-3-Hydroxydecanoyl-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_3hddcoa_c" name="(S)-3-Hydroxydodecanoyl-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_3hhcoa_c" name="(S)-3-Hydroxyhexanoyl-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_3hhdcoa_c" name="(S)-3-Hydroxyhexadecanoyl-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_3hmrsACP_c" name="(R)-3-Hydroxytetradecanoyl-[acyl-carrierprotein]" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_3hocoa_c" name="(S)-3-Hydroxyoctanoyl-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_3htdcoa_c" name="(S)-3-Hydroxytetradecanoyl-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_3ig3p_c" name="C#-(3-Indolyl)-glycerol3-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_3mob_c" name="3-Methyl-2-oxobutanoate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_3mop_c" name="(S)-3-Methyl-2-oxopentanoate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_3odcoa_c" name="3-Oxodecanoyl-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_3oddcoa_c" name="3-Oxododecanoyl-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_3ohcoa_c" name="3-Oxohexanoyl-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_3ohdcoa_c" name="3-Oxohexadecanoyl-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_3omrsACP_c" name="3-Oxotetradecanoyl-[acyl-carrierprotein]" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_3oocoa_c" name="3-Oxooctanoyl-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_3ophb_c" name="3-Octaprenyl-4-hydroxybenzoate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_3otdcoa_c" name="3-Oxotetradecanoyl-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_3pg_c" name="3-Phospho-D-glycerate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_3php_c" name="3-Phosphohydroxypyruvate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_3psme_c" name="5-O-(1-Carboxyvinyl)-3-phosphoshikimate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_4abz_c" name="4-Aminobenzoate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_4adcho_c" name="4-amino-4-deoxychorismate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_4ampm_c" name="4-Amino-2-methyl-5-phosphomethylpyrimidine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_4c2me_c" name="4-(cytidine5#-diphospho)-2-C-methyl-D-erythritol" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_4crsol_c" name="p-Cresol" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_4fe4s_c" name="[4Fe-4S]iron-sulfurcluster" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_4hbz_c" name="4-Hydroxybenzoate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_4mop_c" name="4-Methyl-2-oxopentanoate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_4mpetz_c" name="4-Methyl-5-(2-phosphoethyl)-thiazole" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_4pasp_c" name="4-Phospho-L-aspartate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_4per_c" name="4-Phospho-D-erythronate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_4ppan_c" name="D-4#-Phosphopantothenate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_4ppcys_c" name="N-((R)-4-Phosphopantothenoyl)-L-cysteine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_4r5au_c" name="4-(1-D-Ribitylamino)-5-aminouracil" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_5aizc_c" name="5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_5aop_c" name="5-Amino-4-oxopentanoate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_5aprbu_c" name="5-Amino-6-(5#-phosphoribitylamino)uracil" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_5apru_c" name="5-Amino-6-(5#-phosphoribosylamino)uracil" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_5caiz_c" name="5-phosphoribosyl-5-carboxyaminoimidazole" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_5drib_c" name="5#-deoxyribose" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_5mthf_c" name="5-Methyltetrahydrofolate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_6hmhpt_c" name="6-hydroxymethyldihydropterin" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_6hmhptpp_c" name="6-hydroxymethyl-dihydropterinpyrophosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_6pgc_c" name="6-Phospho-D-gluconate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_6pgl_c" name="6-phospho-D-glucono-1,5-lactone" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_8aonn_c" name="8-Amino-7-oxononanoate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_ACP_c" name="acylcarrierprotein" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_aacoa_c" name="Acetoacetyl-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_ac_c" name="Acetate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_acald_c" name="Acetaldehyde" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_accoa_c" name="Acetyl-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_acg5p_c" name="N-Acetyl-L-glutamyl5-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_acg5sa_c" name="N-Acetyl-L-glutamate5-semialdehyde" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_acgam1p_c" name="N-Acetyl-D-glucosamine1-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_acglu_c" name="N-Acetyl-L-glutamate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_acon__C_c" name="cis-Aconitate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_acorn_c" name="N2-Acetyl-L-ornithine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_acser_c" name="O-Acetyl-L-serine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_actp_c" name="Acetylphosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_ade_c" name="Adenine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_adn_c" name="Adenosine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_adp_c" name="ADP" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_ahcys_c" name="S-Adenosyl-L-homocysteine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_ahdt_c" name="2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridinetriphosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_aicar_c" name="5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_air_c" name="5-amino-1-(5-phospho-D-ribosyl)imidazole" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_akg_c" name="2-Oxoglutarate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_ala__B_c" name="beta-Alanine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_ala__D_c" name="D-Alanine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_ala__L_c" name="L-Alanine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_alaala_c" name="D-Alanyl-D-alanine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_alac__S_c" name="(S)-2-Acetolactate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_amet_c" name="S-Adenosyl-L-methionine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_amob_c" name="S-Adenosyl-4-methylthio-2-oxobutanoate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_amp_c" name="AMP" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_anth_c" name="Anthranilate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_aps_c" name="Adenosine5#-phosphosulfate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_ara5p_c" name="D-Arabinose5-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_arg__L_c" name="L-Arginine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_argsuc_c" name="N(omega)-(L-Arginino)succinate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_asn__L_c" name="L-Asparagine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_asp__L_c" name="L-Aspartate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_aspsa_c" name="L-Aspartate4-semialdehyde" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_atp_c" name="ATP" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_b2coa_c" name="Crotonoyl-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_bmoco_c" name="bis-molybdenumcofactor" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_bmoco1gdp_c" name="bis-molybdopterinmono-guaninedinucleotide" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_bmocogdp_c" name="bis-molybdopteringuaninedinucleotide" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_btcoa_c" name="Butanoyl-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_btn_c" name="Biotin" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_ca2_c" name="Calcium" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_cbasp_c" name="N-Carbamoyl-L-aspartate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_cbp_c" name="Carbamoylphosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_cdp_c" name="CDP" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_cdpdhdec9eg_c" name="CDP-1,2-dihexadec-9-enoylglycerol" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_cdpdhdecg_c" name="CDP-1,2-dihexadecanoylglycerol" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_chor_c" name="chorismate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_cit_c" name="Citrate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_citr__L_c" name="L-Citrulline" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_ckdo_c" name="CMP-3-deoxy-D-manno-octulosonate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_cl_c" name="Chloride" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_cmp_c" name="CMP" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_co2_c" name="CO2" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_coa_c" name="CoenzymeA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_cobalt2_c" name="Co2+" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_cpmp_c" name="cyclicpyranopterinmonophosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_cpppg3_c" name="CoproporphyrinogenIII" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_ctp_c" name="CTP" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_cu2_c" name="Cu2+" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_cys__L_c" name="L-Cysteine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_cyst__L_c" name="L-Cystathionine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_dad__2_c" name="Deoxyadenosine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_dad__5_c" name="5#-Deoxyadenosine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_dadp_c" name="dADP" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_damp_c" name="dAMP" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_dann_c" name="7,8-Diaminononanoate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_datp_c" name="dATP" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_db4p_c" name="3,4-dihydroxy-2-butanone4-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_dc2coa_c" name="trans-Dec-2-enoyl-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_dcacoa_c" name="Decanoyl-CoA(n-C10:0CoA)" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_dcamp_c" name="N6-(1,2-Dicarboxyethyl)-AMP" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_dctp_c" name="dCTP" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_dd2coa_c" name="trans-Dodec-2-enoyl-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_ddca_c" name="Dodecanoate(n-C12:0)" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_ddcaACP_c" name="Dodecanoyl-ACP(n-C12:0ACP)" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_ddcacoa_c" name="Dodecanoyl-CoA(n-C12:0CoA)" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_dgtp_c" name="dGTP" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_dha_c" name="Dihydroxyacetone" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_dhap_c" name="Dihydroxyacetonephosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_dhf_c" name="7,8-Dihydrofolate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_dhgly_c" name="dehydroglycine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_dhnpt_c" name="Dihydroneopterin" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_dhor__S_c" name="(S)-Dihydroorotate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_dhpmp_c" name="Dihydroneopterinmonophosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_dhpt_c" name="Dihydropteroate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_dhptd_c" name="4,5-dihydroxy-2,3-pentanedione" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_dmlz_c" name="6,7-Dimethyl-8-(1-D-ribityl)lumazine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_dmpp_c" name="Dimethylallyldiphosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_dnad_c" name="Deamino-NAD+" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_dpcoa_c" name="Dephospho-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_dscl_c" name="dihydrosirohydrochlorin" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_dtbt_c" name="Dethiobiotin" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_dtdp_c" name="dTDP" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_dtmp_c" name="dTMP" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_dttp_c" name="dTTP" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_dump_c" name="dUMP" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_duri_c" name="Deoxyuridine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_dxyl5p_c" name="1-deoxy-D-xylulose5-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_e4p_c" name="D-Erythrose4-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_egmeACP_c" name="Enoylglutaryl-[acyl-carrierprotein]methylester" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_eig3p_c" name="D-erythro-1-(Imidazol-4-yl)glycerol3-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_epmeACP_c" name="Enoylpimeloyl-[acyl-carrierprotein]methylester" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_etoh_c" name="Ethanol" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_f6p_c" name="D-Fructose6-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_fad_c" name="Flavinadeninedinucleotideoxidized" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_fadh2_c" name="Flavinadeninedinucleotidereduced" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_fdp_c" name="D-Fructose1,6-bisphosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_fe2_c" name="Fe2+" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_fe3_c" name="Fe3+" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_fgam_c" name="N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_flxr_c" name="Flavodoxinreduced" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_flxso_c" name="flavodoxinsemioxidized" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_fmn_c" name="FMN" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_for_c" name="Formate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_fpram_c" name="2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_fprica_c" name="5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_frdp_c" name="Farnesyldiphosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_fum_c" name="Fumarate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_g3p_c" name="Glyceraldehyde3-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_g6p_c" name="D-Glucose6-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_gam1p_c" name="D-Glucosamine1-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_gam6p_c" name="D-Glucosamine6-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_gar_c" name="N1-(5-Phospho-D-ribosyl)glycinamide" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_gcald_c" name="Glycolaldehyde" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_gdp_c" name="GDP" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_glc__D_c" name="D-Glucose" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_gln__L_c" name="L-Glutamine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_glu__D_c" name="D-Glutamate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_glu__L_c" name="L-Glutamate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_glu1sa_c" name="L-Glutamate1-semialdehyde" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_glu5p_c" name="L-Glutamate5-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_glu5sa_c" name="L-Glutamate5-semialdehyde" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_glutrna_c" name="L-Glutamyl-tRNA(Glu)" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_glx_c" name="Glyoxylate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_gly_c" name="Glycine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_glyc_c" name="Glycerol" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_glyc__R_c" name="(R)-Glycerate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_glyc3p_c" name="Glycerol3-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_glyclt_c" name="Glycolate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_gmeACP_c" name="Glutaryl-[acyl-carrierprotein]methylester" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_gmp_c" name="GMP" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_grdp_c" name="Geranyldiphosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_grxox_c" name="glutaredoxin(oxidized)" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_grxrd_c" name="glutaredoxin(reduced)" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_gthox_c" name="Oxidizedglutathione" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_gthrd_c" name="Reducedglutathione" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_gtp_c" name="GTP" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_h_c" name="H+" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_h2_c" name="H2" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_h2mb4p_c" name="1-hydroxy-2-methyl-2-(E)-butenyl4-diphosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_h2o_c" name="H2O" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_h2s_c" name="Hydrogensulfide" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_hco3_c" name="Bicarbonate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_hcys__L_c" name="L-Homocysteine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_hdca_c" name="Hexadecanoate(n-C16:0)" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_hdcap_c" name="Hexadecanoyl-phosphate(n-C16:0)" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_hdcea_c" name="Hexadecenoate(n-C16:1)" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_hdceap_c" name="Hexadecanoyl-phosphate(n-C16:1)" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_hdcoa_c" name="Hexadecenoyl-CoA(n-C16:1CoA)" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_hdd2coa_c" name="trans-Hexadec-2-enoyl-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_hdeACP_c" name="cis-hexadec-9-enoyl-[acyl-carrierprotein](n-C16:1)" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_hgmeACP_c" name="3-Hydroxyglutaryl-[acyl-carrierprotein]methylester" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_his__L_c" name="L-Histidine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_hisp_c" name="L-Histidinolphosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_histd_c" name="L-Histidinol" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_hmbil_c" name="Hydroxymethylbilane" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_hom__L_c" name="L-Homoserine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_hpmeACP_c" name="3-Hydroxypimeloyl-[acyl-carrierprotein]methylester" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_hx2coa_c" name="trans-Hex-2-enoyl-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_hxcoa_c" name="Hexanoyl-CoA(n-C6:0CoA)" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_iasp_c" name="Iminoaspartate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_icit_c" name="Isocitrate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_ile__L_c" name="L-Isoleucine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_imacp_c" name="3-(Imidazol-4-yl)-2-oxopropylphosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_imp_c" name="IMP" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_indole_c" name="Indole" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_ipdp_c" name="Isopentenyldiphosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_iscs_c" name="IscSsulfuracceptorprotein" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_iscssh_c" name="IscSwithboundsulfur" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_iscu_c" name="IscUscaffoldprotein" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_iscu__2fe2s_c" name="IscUwithbound[2Fe-2S]cluster" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_iscu__2fe2s2_c" name="IscUwithtwobound[2Fe-2S]clusters" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_iscu__4fe4s_c" name="IscUwithbound[4Fe-4S]cluster" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_k_c" name="potassium" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_kdo_c" name="3-Deoxy-D-manno-2-octulosonate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_kdo2lipid4_c" name="KDO(2)-lipidIV(A)" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_kdo8p_c" name="3-Deoxy-D-manno-octulosonate8-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_kdolipid4_c" name="KDO-lipidIV(A)" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_lac__D_c" name="D-Lactate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_leu__L_c" name="L-Leucine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_lipidA_c" name="2,3,2#3#-Tetrakis(beta-hydroxymyristoyl)-D-glucosaminyl-1,6-beta-D-glucosamine1,4#-bisphosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_lipidAds_c" name="LipidADisaccharide" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_lipidX_c" name="2,3-Bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl1-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_lys__L_c" name="L-Lysine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_mal__L_c" name="L-Malate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_malACP_c" name="Malonyl-[acyl-carrierprotein]" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_malcoa_c" name="Malonyl-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_malcoame_c" name="malonyl-CoAmethylester" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_mdhdhf_c" name="(2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_meoh_c" name="Methanol" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_met__L_c" name="L-Methionine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_methf_c" name="5,10-Methenyltetrahydrofolate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_mg2_c" name="magnesium" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_mlthf_c" name="5,10-Methylenetetrahydrofolate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_mn2_c" name="Mn2+" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_moadamp_c" name="MoaDProteinwithboundAMP" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_moadcoo_c" name="MoaDProteinwithcarboxylate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_moadcosh_c" name="MoaDProteinwiththiocarboxylate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_mobd_c" name="Molybdate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_moco_c" name="molybdenumcofactor" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_mpt_c" name="molybdopterin" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_mptamp_c" name="adenylatedmolybdopterin" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_mql8_c" name="Menaquinol8" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_mqn8_c" name="Menaquinone8" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_mthgxl_c" name="Methylglyoxal" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_mththf_c" name="(2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_na1_c" name="Sodium" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_nad_c" name="Nicotinamideadeninedinucleotide" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_nadh_c" name="Nicotinamideadeninedinucleotide-reduced" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_nadp_c" name="Nicotinamideadeninedinucleotidephosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_nadph_c" name="Nicotinamideadeninedinucleotidephosphate-reduced" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_nh4_c" name="Ammonium" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_ni2_c" name="nickel" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_nicrnt_c" name="NicotinateD-ribonucleotide" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_o2_c" name="O2" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_oaa_c" name="Oxaloacetate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_oc2coa_c" name="trans-Oct-2-enoyl-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_occoa_c" name="Octanoyl-CoA(n-C8:0CoA)" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_octdp_c" name="all-trans-Octaprenyldiphosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_ogmeACP_c" name="3-Oxo-glutaryl-[acyl-carrierprotein]methylester" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_ohpb_c" name="2-Oxo-3-hydroxy-4-phosphobutanoate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_opmeACP_c" name="3-Oxo-pimeloyl-[acyl-carrierprotein]methylester" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_orn_c" name="Ornithine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_orot_c" name="Orotate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_orot5p_c" name="Orotidine5#-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_pa160_c" name="1,2-dihexadecanoyl-sn-glycerol3-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_pa161_c" name="1,2-dihexadec-9-enoyl-sn-glycerol3-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_palmACP_c" name="Palmitoyl-ACP(n-C16:0ACP)" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_pan4p_c" name="Pantetheine4#-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_pant__R_c" name="(R)-Pantoate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_pap_c" name="Adenosine3#,5#-bisphosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_paps_c" name="3#-Phosphoadenylylsulfate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_pdx5p_c" name="Pyridoxine5#-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_pe160_c" name="phosphatidylethanolamine(dihexadecanoyl,n-C16:0)" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_pe161_c" name="phosphatidylethanolamine(dihexadec-9enoyl,n-C16:1)" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_pep_c" name="Phosphoenolpyruvate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_phe__L_c" name="L-Phenylalanine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_pheme_c" name="Protoheme" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_phom_c" name="O-Phospho-L-homoserine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_phpyr_c" name="Phenylpyruvate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_phthr_c" name="O-Phospho-4-hydroxy-L-threonine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_pi_c" name="Phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_pimACP_c" name="Pimeloyl-[acyl-carrierprotein]" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_pmeACP_c" name="Pimeloyl-[acyl-carrierprotein]methylester" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_pmtcoa_c" name="Palmitoyl-CoA(n-C16:0CoA)" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_pnto__R_c" name="(R)-Pantothenate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_ppbng_c" name="Porphobilinogen" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_pphn_c" name="Prephenate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_ppi_c" name="Diphosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_ppp9_c" name="Protoporphyrin" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_pppg9_c" name="ProtoporphyrinogenIX" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_pram_c" name="5-Phospho-beta-D-ribosylamine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_pran_c" name="N-(5-Phospho-D-ribosyl)anthranilate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_prbamp_c" name="1-(5-Phosphoribosyl)-AMP" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_prbatp_c" name="1-(5-Phosphoribosyl)-ATP" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_prfp_c" name="1-(5-Phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_prlp_c" name="5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_pro__L_c" name="L-Proline" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_prpp_c" name="5-Phospho-alpha-D-ribose1-diphosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_ps160_c" name="phosphatidylserine(dihexadecanoyl,n-C16:0)" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_ps161_c" name="phosphatidylserine(dihexadec-9-enoyl,n-C16:1)" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_pser__L_c" name="O-Phospho-L-serine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_pydx5p_c" name="Pyridoxal5#-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_pyr_c" name="Pyruvate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_q8_c" name="Ubiquinone-8" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_q8h2_c" name="Ubiquinol-8" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_quln_c" name="Quinolinate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_r1p_c" name="alpha-D-Ribose1-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_r5p_c" name="alpha-D-Ribose5-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_rhcys_c" name="S-Ribosyl-L-homocysteine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_ribflv_c" name="Riboflavin" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_ru5p__D_c" name="D-Ribulose5-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_s7p_c" name="Sedoheptulose7-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_scl_c" name="sirohydrochlorin" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_ser__L_c" name="L-Serine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_sheme_c" name="Siroheme" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_skm_c" name="Shikimate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_skm5p_c" name="Shikimate5-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_sl26da_c" name="N-Succinyl-LL-2,6-diaminoheptanedioate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_sl2a6o_c" name="N-Succinyl-2-L-amino-6-oxoheptanedioate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_so3_c" name="Sulfite" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_so4_c" name="Sulfate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_succ_c" name="Succinate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_succoa_c" name="Succinyl-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_suchms_c" name="O-Succinyl-L-homoserine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_td2coa_c" name="trans-Tetradec-2-enoyl-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_tdcoa_c" name="Tetradecanoyl-CoA(n-C14:0CoA)" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_thdp_c" name="2,3,4,5-Tetrahydrodipicolinate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_thf_c" name="5,6,7,8-Tetrahydrofolate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_thmmp_c" name="Thiaminmonophosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_thmpp_c" name="Thiaminediphosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_thr__L_c" name="L-Threonine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_trnaglu_c" name="tRNA(Glu)" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_trp__L_c" name="L-Tryptophan" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_tyr__L_c" name="L-Tyrosine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_u23ga_c" name="UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_u3aga_c" name="UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_u3hga_c" name="UDP-3-O-(3-hydroxytetradecanoyl)-D-glucosamine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_uaagmda_c" name="Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-ala-D-glu-meso-2,6-diaminopimeloyl-D-ala-D-ala" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_uaccg_c" name="UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_uacgam_c" name="UDP-N-acetyl-D-glucosamine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_uagmda_c" name="Undecaprenyl-diphospho-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_uama_c" name="UDP-N-acetylmuramoyl-L-alanine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_uamag_c" name="UDP-N-acetylmuramoyl-L-alanyl-D-glutamate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_uamr_c" name="UDP-N-acetylmuramate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_udcpdp_c" name="Undecaprenyldiphosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_udcpp_c" name="Undecaprenylphosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_udp_c" name="UDP" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_ugmd_c" name="UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminopimelate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_ugmda_c" name="UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_ump_c" name="UMP" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_uppg3_c" name="UroporphyrinogenIII" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_ura_c" name="Uracil" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_uri_c" name="Uridine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_utp_c" name="UTP" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_val__L_c" name="L-Valine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_xmp_c" name="Xanthosine5#-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_xu5p__D_c" name="D-Xylulose5-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_zn2_c" name="Zinc" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_ac_e" name="Acetate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_ca2_e" name="Calcium" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_cl_e" name="Chloride" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_co2_e" name="CO2" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_cobalt2_e" name="Co2+" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_cu2_e" name="Cu2+" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_etoh_e" name="Ethanol" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_fe2_e" name="Fe2+" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_fe3_e" name="Fe3+" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_for_e" name="Formate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_glc__D_e" name="D-Glucose" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_glyc_e" name="Glycerol" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_h_e" name="H+" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_h2_e" name="H2" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_h2o_e" name="H2O" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_k_e" name="potassium" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_kdo2lipid4_e" name="KDO(2)-lipidIV(A)" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_lac__D_e" name="D-Lactate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_meoh_e" name="Methanol" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_mg2_e" name="magnesium" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_mn2_e" name="Mn2+" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_mobd_e" name="Molybdate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_nh4_e" name="Ammonium" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_ni2_e" name="nickel" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_o2_e" name="O2" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_pi_e" name="Phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_so4_e" name="Sulfate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_succ_e" name="Succinate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_zn2_e" name="Zinc" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_ac_p" name="Acetate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_ala__D_p" name="D-Alanine" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_ca2_p" name="Calcium" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_cl_p" name="Chloride" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_co2_p" name="CO2" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_cobalt2_p" name="Co2+" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_cu2_p" name="Cu2+" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_etoh_p" name="Ethanol" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_fe2_p" name="Fe2+" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_fe3_p" name="Fe3+" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_for_p" name="Formate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_glc__D_p" name="D-Glucose" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_glyc_p" name="Glycerol" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_h_p" name="H+" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_h2_p" name="H2" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_h2o_p" name="H2O" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_k_p" name="potassium" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_kdo2lipid4_p" name="KDO(2)-lipidIV(A)" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_lac__D_p" name="D-Lactate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_meoh_p" name="Methanol" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_mg2_p" name="magnesium" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_mn2_p" name="Mn2+" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_mobd_p" name="Molybdate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_murein5p5p_p" name="twolinkeddisacharidepentapeptidemureinunits(uncrosslinked,middleofchain)" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_murein5px4p_p" name="twodisacharidelinkedmureinunits,pentapeptidecrosslinkedtetrapeptide(A2pm-D-ala)(middleofchain)" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_na1_p" name="Sodium" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_nh4_p" name="Ammonium" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_ni2_p" name="nickel" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_o2_p" name="O2" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_pe160_p" name="phosphatidylethanolamine(dihexadecanoyl,n-C16:0)" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_pe161_p" name="phosphatidylethanolamine(dihexadec-9enoyl,n-C16:1)" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_pi_p" name="Phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_pro__L_p" name="L-Proline" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_so4_p" name="Sulfate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_succ_p" name="Succinate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_zn2_p" name="Zinc" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_glxBIO_c" name="M_glxBIO_c" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_forBIO_c" name="M_forBIO_c" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+    </listOfSpecies>
+    <listOfParameters>
+      <parameter sboTerm="SBO:0000626" id="cobra_default_lb" value="-INF" constant="true"/>
+      <parameter sboTerm="SBO:0000626" id="cobra_default_ub" value="INF" constant="true"/>
+      <parameter sboTerm="SBO:0000626" id="cobra_0_bound" value="0" constant="true"/>
+      <parameter sboTerm="SBO:0000626" id="minus_inf" value="-INF" constant="true"/>
+      <parameter sboTerm="SBO:0000626" id="plus_inf" value="INF" constant="true"/>
+      <parameter sboTerm="SBO:0000625" id="R_EX_co2_e_lower_bound" value="-10" units="mmol_per_gDW_per_hr" constant="true"/>
+      <parameter sboTerm="SBO:0000625" id="R_EX_glc_e_lower_bound" value="-10" units="mmol_per_gDW_per_hr" constant="true"/>
+      <parameter sboTerm="SBO:0000625" id="R_ATPM_lower_bound" value="3.15" units="mmol_per_gDW_per_hr" constant="true"/>
+    </listOfParameters>
+    <listOfReactions>
+      <reaction metaid="meta_R_EX_Biomass" sboTerm="SBO:0000627" id="R_EX_Biomass" name="EX_Biomass" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf"/>
+      <reaction id="R_DM_4CRSOL" name="R_DM_4CRSOL" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_4crsol_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction id="R_DM_5DRIB" name="R_DM_5DRIB" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_5drib_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction id="R_DM_AMOB" name="R_DM_AMOB" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_amob_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction id="R_DM_MTHTHF" name="R_DM_MTHTHF" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_mththf_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction id="R_Ec_biomass_iJO1366_core_53p95M" name="R_Ec_biomass_iJO1366_core_53p95M" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_10fthf_c" stoichiometry="0.000223" constant="true"/>
+          <speciesReference species="M_2fe2s_c" stoichiometry="2.6e-05" constant="true"/>
+          <speciesReference species="M_2ohph_c" stoichiometry="0.000223" constant="true"/>
+          <speciesReference species="M_4fe4s_c" stoichiometry="0.00026" constant="true"/>
+          <speciesReference species="M_ala__L_c" stoichiometry="0.51369" constant="true"/>
+          <speciesReference species="M_amet_c" stoichiometry="0.000223" constant="true"/>
+          <speciesReference species="M_arg__L_c" stoichiometry="0.29579" constant="true"/>
+          <speciesReference species="M_asn__L_c" stoichiometry="0.24105" constant="true"/>
+          <speciesReference species="M_asp__L_c" stoichiometry="0.24105" constant="true"/>
+          <speciesReference species="M_atp_c" stoichiometry="54.1248" constant="true"/>
+          <speciesReference species="M_bmocogdp_c" stoichiometry="0.000122" constant="true"/>
+          <speciesReference species="M_btn_c" stoichiometry="2e-06" constant="true"/>
+          <speciesReference species="M_ca2_c" stoichiometry="0.005205" constant="true"/>
+          <speciesReference species="M_cl_c" stoichiometry="0.005205" constant="true"/>
+          <speciesReference species="M_coa_c" stoichiometry="0.000576" constant="true"/>
+          <speciesReference species="M_cobalt2_c" stoichiometry="2.5e-05" constant="true"/>
+          <speciesReference species="M_ctp_c" stoichiometry="0.13351" constant="true"/>
+          <speciesReference species="M_cu2_c" stoichiometry="0.000709" constant="true"/>
+          <speciesReference species="M_cys__L_c" stoichiometry="0.09158" constant="true"/>
+          <speciesReference species="M_datp_c" stoichiometry="0.026166" constant="true"/>
+          <speciesReference species="M_dctp_c" stoichiometry="0.027017" constant="true"/>
+          <speciesReference species="M_dgtp_c" stoichiometry="0.027017" constant="true"/>
+          <speciesReference species="M_dttp_c" stoichiometry="0.026166" constant="true"/>
+          <speciesReference species="M_fad_c" stoichiometry="0.000223" constant="true"/>
+          <speciesReference species="M_fe2_c" stoichiometry="0.006715" constant="true"/>
+          <speciesReference species="M_fe3_c" stoichiometry="0.007808" constant="true"/>
+          <speciesReference species="M_gln__L_c" stoichiometry="0.26316" constant="true"/>
+          <speciesReference species="M_glu__L_c" stoichiometry="0.26316" constant="true"/>
+          <speciesReference species="M_gly_c" stoichiometry="0.61264" constant="true"/>
+          <speciesReference species="M_gtp_c" stoichiometry="0.2151" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="48.6015" constant="true"/>
+          <speciesReference species="M_his__L_c" stoichiometry="0.094738" constant="true"/>
+          <speciesReference species="M_ile__L_c" stoichiometry="0.29053" constant="true"/>
+          <speciesReference species="M_k_c" stoichiometry="0.19519" constant="true"/>
+          <speciesReference species="M_leu__L_c" stoichiometry="0.45053" constant="true"/>
+          <speciesReference species="M_lys__L_c" stoichiometry="0.34316" constant="true"/>
+          <speciesReference species="M_met__L_c" stoichiometry="0.15369" constant="true"/>
+          <speciesReference species="M_mg2_c" stoichiometry="0.008675" constant="true"/>
+          <speciesReference species="M_mlthf_c" stoichiometry="0.000223" constant="true"/>
+          <speciesReference species="M_mn2_c" stoichiometry="0.000691" constant="true"/>
+          <speciesReference species="M_mobd_c" stoichiometry="7e-06" constant="true"/>
+          <speciesReference species="M_nad_c" stoichiometry="0.001831" constant="true"/>
+          <speciesReference species="M_nadp_c" stoichiometry="0.000447" constant="true"/>
+          <speciesReference species="M_nh4_c" stoichiometry="0.013013" constant="true"/>
+          <speciesReference species="M_ni2_c" stoichiometry="0.000323" constant="true"/>
+          <speciesReference species="M_pe160_c" stoichiometry="0.017868" constant="true"/>
+          <speciesReference species="M_pe161_c" stoichiometry="0.054154" constant="true"/>
+          <speciesReference species="M_phe__L_c" stoichiometry="0.18527" constant="true"/>
+          <speciesReference species="M_pheme_c" stoichiometry="0.000223" constant="true"/>
+          <speciesReference species="M_pro__L_c" stoichiometry="0.22106" constant="true"/>
+          <speciesReference species="M_pydx5p_c" stoichiometry="0.000223" constant="true"/>
+          <speciesReference species="M_ribflv_c" stoichiometry="0.000223" constant="true"/>
+          <speciesReference species="M_ser__L_c" stoichiometry="0.21579" constant="true"/>
+          <speciesReference species="M_sheme_c" stoichiometry="0.000223" constant="true"/>
+          <speciesReference species="M_so4_c" stoichiometry="0.004338" constant="true"/>
+          <speciesReference species="M_thf_c" stoichiometry="0.000223" constant="true"/>
+          <speciesReference species="M_thmpp_c" stoichiometry="0.000223" constant="true"/>
+          <speciesReference species="M_thr__L_c" stoichiometry="0.25369" constant="true"/>
+          <speciesReference species="M_trp__L_c" stoichiometry="0.056843" constant="true"/>
+          <speciesReference species="M_tyr__L_c" stoichiometry="0.1379" constant="true"/>
+          <speciesReference species="M_udcpdp_c" stoichiometry="5.5e-05" constant="true"/>
+          <speciesReference species="M_utp_c" stoichiometry="0.1441" constant="true"/>
+          <speciesReference species="M_val__L_c" stoichiometry="0.42316" constant="true"/>
+          <speciesReference species="M_zn2_c" stoichiometry="0.000341" constant="true"/>
+          <speciesReference species="M_kdo2lipid4_e" stoichiometry="0.019456" constant="true"/>
+          <speciesReference species="M_murein5px4p_p" stoichiometry="0.013894" constant="true"/>
+          <speciesReference species="M_pe160_p" stoichiometry="0.045946" constant="true"/>
+          <speciesReference species="M_pe161_p" stoichiometry="0.02106" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="53.95" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="53.95" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="53.9457" constant="true"/>
+          <speciesReference species="M_ppi_c" stoichiometry="0.7739" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_EX_ac_e" name="R_EX_ac_LPAREN_e_RPAREN_" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_ac_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction id="R_EX_ca2_e" name="R_EX_ca2_LPAREN_e_RPAREN_" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_ca2_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction id="R_EX_cl_e" name="R_EX_cl_LPAREN_e_RPAREN_" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_cl_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction id="R_EX_co2_e" name="R_EX_co2_LPAREN_e_RPAREN_" reversible="true" fast="false" fbc:lowerFluxBound="R_EX_co2_e_lower_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_co2_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction id="R_EX_cobalt2_e" name="R_EX_cobalt2_LPAREN_e_RPAREN_" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_cobalt2_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction id="R_EX_cu2_e" name="R_EX_cu2_LPAREN_e_RPAREN_" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_cu2_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction id="R_EX_etoh_e" name="R_EX_etoh_LPAREN_e_RPAREN_" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_etoh_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction id="R_EX_fe2_e" name="R_EX_fe2_LPAREN_e_RPAREN_" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_fe2_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction id="R_EX_fe3_e" name="R_EX_fe3_LPAREN_e_RPAREN_" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_fe3_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction id="R_EX_for_e" name="R_EX_for_LPAREN_e_RPAREN_" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_for_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction id="R_EX_glc_e" name="R_EX_glc_LPAREN_e_RPAREN_" reversible="true" fast="false" fbc:lowerFluxBound="R_EX_glc_e_lower_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_glc__D_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction id="R_EX_glyc_e" name="R_EX_glyc_LPAREN_e_RPAREN_" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_glyc_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction id="R_EX_h_e" name="R_EX_h_LPAREN_e_RPAREN_" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction id="R_EX_h2_e" name="R_EX_h2_LPAREN_e_RPAREN_" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h2_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction id="R_EX_h2o_e" name="R_EX_h2o_LPAREN_e_RPAREN_" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h2o_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction id="R_EX_k_e" name="R_EX_k_LPAREN_e_RPAREN_" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_k_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction id="R_EX_lac__D_e" name="R_EX_lac_DASH_D_LPAREN_e_RPAREN_" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_lac__D_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction id="R_EX_meoh_e" name="R_EX_meoh_LPAREN_e_RPAREN_" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_meoh_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction id="R_EX_mg2_e" name="R_EX_mg2_LPAREN_e_RPAREN_" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_mg2_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction id="R_EX_mn2_e" name="R_EX_mn2_LPAREN_e_RPAREN_" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_mn2_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction id="R_EX_mobd_e" name="R_EX_mobd_LPAREN_e_RPAREN_" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_mobd_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction id="R_EX_nh4_e" name="R_EX_nh4_LPAREN_e_RPAREN_" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_nh4_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction id="R_EX_ni2_e" name="R_EX_ni2_LPAREN_e_RPAREN_" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_ni2_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction id="R_EX_o2_e" name="R_EX_o2_LPAREN_e_RPAREN_" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_o2_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction id="R_EX_pi_e" name="R_EX_pi_LPAREN_e_RPAREN_" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_pi_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction id="R_EX_so4_e" name="R_EX_so4_LPAREN_e_RPAREN_" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_so4_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction id="R_EX_succ_e" name="R_EX_succ_LPAREN_e_RPAREN_" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_succ_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction id="R_EX_zn2_e" name="R_EX_zn2_LPAREN_e_RPAREN_" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_zn2_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction id="R_3OAR140" name="R_3OAR140" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_3omrsACP_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_3hmrsACP_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_3OAS140" name="R_3OAS140" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_ddcaACP_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_malACP_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_3omrsACP_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ACP_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_5DOAN" name="R_5DOAN" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_dad__5_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_5drib_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ade_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_A5PISO" name="R_A5PISO" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_ru5p__D_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_ara5p_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_AACPS3" name="R_AACPS3" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_ACP_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_hdca_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_amp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_palmACP_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_AACPS4" name="R_AACPS4" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_ACP_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_hdcea_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_amp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_hdeACP_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_AACPS7" name="R_AACPS7" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_ACP_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ddca_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_amp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ddcaACP_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ACACT1r" name="R_ACACT1r" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_accoa_c" stoichiometry="2" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_aacoa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ACACT2r" name="R_ACACT2r" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_accoa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_btcoa_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_3ohcoa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ACACT3r" name="R_ACACT3r" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_accoa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_hxcoa_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_3oocoa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ACACT4r" name="R_ACACT4r" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_accoa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_occoa_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_3odcoa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ACACT5r" name="R_ACACT5r" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_accoa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_dcacoa_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_3oddcoa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ACACT6r" name="R_ACACT6r" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_accoa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ddcacoa_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_3otdcoa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ACACT7r" name="R_ACACT7r" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_accoa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_tdcoa_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_3ohdcoa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ACALD" name="R_ACALD" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_acald_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_accoa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ACCOAC" name="R_ACCOAC" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_accoa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_hco3_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_malcoa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ACGK" name="R_ACGK" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_acglu_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_acg5p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ACGS" name="R_ACGS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_accoa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_acglu_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ACHBS" name="R_ACHBS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_2obut_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_2ahbut_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ACKr" name="R_ACKr" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_ac_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_actp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ACLS" name="R_ACLS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pyr_c" stoichiometry="2" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_alac__S_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ACOAD1f" name="R_ACOAD1f" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_btcoa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_fad_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_b2coa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_fadh2_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ACOAD2f" name="R_ACOAD2f" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_fad_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_hxcoa_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_fadh2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_hx2coa_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ACOAD3f" name="R_ACOAD3f" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_fad_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_occoa_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_fadh2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_oc2coa_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ACOAD4f" name="R_ACOAD4f" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_dcacoa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_fad_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_dc2coa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_fadh2_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ACOAD5f" name="R_ACOAD5f" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_ddcacoa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_fad_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_dd2coa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_fadh2_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ACOAD6f" name="R_ACOAD6f" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_fad_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_tdcoa_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_fadh2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_td2coa_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ACOAD7f" name="R_ACOAD7f" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_fad_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pmtcoa_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_fadh2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_hdd2coa_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ACODA" name="R_ACODA" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_acorn_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_ac_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_orn_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ACONTa" name="R_ACONTa" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_cit_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_acon__C_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ACONTb" name="R_ACONTb" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_acon__C_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_icit_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ACOTA" name="R_ACOTA" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_acorn_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_akg_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_acg5sa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ACPPAT160" name="R_ACPPAT160" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_palmACP_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_ACP_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_hdcap_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ACPPAT161" name="R_ACPPAT161" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_hdeACP_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_ACP_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_hdceap_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ACt2rpp" name="R_ACt2rpp" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_ac_p" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_p" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_ac_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ACtex" name="R_ACtex" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_ac_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_ac_p" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ADCL" name="R_ADCL" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_4adcho_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_4abz_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ADCS" name="R_ADCS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_chor_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_gln__L_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_4adcho_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ADK1" name="R_ADK1" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_amp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="2" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ADNK1" name="R_ADNK1" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_adn_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_amp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ADSK" name="R_ADSK" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_aps_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_paps_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ADSL1r" name="R_ADSL1r" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_dcamp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_amp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_fum_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ADSL2r" name="R_ADSL2r" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_25aics_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_aicar_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_fum_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ADSS" name="R_ADSS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_asp__L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_gtp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_imp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_dcamp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_gdp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_AGPAT160" name="R_AGPAT160" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_1hdecg3p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_palmACP_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_ACP_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pa160_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_AGPAT161" name="R_AGPAT161" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_1hdec9eg3p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_hdeACP_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_ACP_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pa161_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_AGPR" name="R_AGPR" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_acg5sa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_acg5p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_AHCYSNS" name="R_AHCYSNS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_ahcys_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_ade_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_rhcys_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_AICART" name="R_AICART" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_10fthf_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_aicar_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_fprica_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_thf_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_AIRC2" name="R_AIRC2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_air_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_hco3_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_5caiz_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_AIRC3" name="R_AIRC3" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_5aizc_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_5caiz_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_AKGDH" name="R_AKGDH" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_akg_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_succoa_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ALAALAr" name="R_ALAALAr" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_ala__D_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_alaala_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ALAR" name="R_ALAR" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_ala__L_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_ala__D_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ALCD2x" name="R_ALCD2x" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_etoh_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_acald_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_AMAOTr" name="R_AMAOTr" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_8aonn_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_amet_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_amob_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_dann_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_AMPMS2" name="R_AMPMS2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_air_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_4ampm_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="3" constant="true"/>
+          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_forBIO_c" stoichiometry="2" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ANPRT" name="R_ANPRT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_anth_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_prpp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pran_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ANS" name="R_ANS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_chor_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_gln__L_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_anth_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_AOXSr2" name="R_AOXSr2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_ala__L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pimACP_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_8aonn_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ACP_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_APG3PAT160" name="R_APG3PAT160" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_glyc3p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_hdcap_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_1hdecg3p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_APG3PAT161" name="R_APG3PAT161" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_glyc3p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_hdceap_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_1hdec9eg3p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_APRAUR" name="R_APRAUR" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_5apru_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_5aprbu_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ARGSL" name="R_ARGSL" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_argsuc_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_arg__L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_fum_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ARGSS" name="R_ARGSS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_asp__L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_citr__L_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_amp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_argsuc_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ASAD" name="R_ASAD" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_aspsa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_4pasp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ASNS2" name="R_ASNS2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_asp__L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nh4_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_amp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_asn__L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ASP1DC" name="R_ASP1DC" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_asp__L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_ala__B_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ASPCT" name="R_ASPCT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_asp__L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_cbp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_cbasp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ASPK" name="R_ASPK" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_asp__L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_4pasp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ASPO5" name="R_ASPO5" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_asp__L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_fum_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_iasp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_succ_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ASPTA" name="R_ASPTA" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_akg_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_asp__L_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_oaa_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ATPM" name="R_ATPM" reversible="false" fast="false" fbc:lowerFluxBound="R_ATPM_lower_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ATPPRT" name="R_ATPPRT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_prpp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_prbatp_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ATPS4rpp" name="R_ATPS4rpp" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_p" stoichiometry="4" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="3" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_BMOCOS" name="R_BMOCOS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_moco_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_mptamp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_amp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_bmoco_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_cu2_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_BMOGDS1" name="R_BMOGDS1" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_bmoco_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_gtp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_bmoco1gdp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_BMOGDS2" name="R_BMOGDS2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_bmoco1gdp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_gtp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_bmocogdp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_BPNT" name="R_BPNT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pap_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_amp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_BTS5" name="R_BTS5" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_2fe2s_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_amet_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_dtbt_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_2fe1s_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_btn_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_dad__5_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_met__L_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_CA2tex" name="R_CA2tex" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_ca2_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_ca2_p" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_CAt6pp" name="R_CAt6pp" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_ca2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_na1_p" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_na1_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ca2_p" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_CBMKr" name="R_CBMKr" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nh4_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_cbp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="2" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_CDPMEK" name="R_CDPMEK" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_4c2me_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_2p4c2me_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_CHORM" name="R_CHORM" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_chor_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_pphn_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_CHORS" name="R_CHORS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_3psme_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_chor_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_CHRPL" name="R_CHRPL" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_chor_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_4hbz_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_CLt3_2pp" name="R_CLt3_2pp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_cl_p" stoichiometry="2" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_cl_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_h_p" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_CLtex" name="R_CLtex" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_cl_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_cl_p" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_CO2tex" name="R_CO2tex" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_co2_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_co2_p" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_CO2tpp" name="R_CO2tpp" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_co2_p" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_COBALT2tex" name="R_COBALT2tex" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_cobalt2_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_cobalt2_p" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_COBALT2tpp" name="R_COBALT2tpp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_cobalt2_p" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_cobalt2_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_CPMPS" name="R_CPMPS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_gtp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_cpmp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_CPPPGO2" name="R_CPPPGO2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_amet_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_cpppg3_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_co2_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_dad__5_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_met__L_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_pppg9_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_CS" name="R_CS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_accoa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_oaa_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_cit_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_CTECOAI7" name="R_CTECOAI7" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_hdcoa_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_hdd2coa_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_CTPS2" name="R_CTPS2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_gln__L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_utp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ctp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_CU2tex" name="R_CU2tex" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_cu2_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_cu2_p" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_CU2tpp" name="R_CU2tpp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_cu2_p" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_cu2_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_CYSS" name="R_CYSS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_acser_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2s_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_ac_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_cys__L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_CYSTL" name="R_CYSTL" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_cyst__L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_hcys__L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nh4_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_CYTBO3_4pp" name="R_CYTBO3_4pp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h_c" stoichiometry="4" constant="true"/>
+          <speciesReference species="M_o2_c" stoichiometry="0.5" constant="true"/>
+          <speciesReference species="M_q8h2_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_q8_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_p" stoichiometry="4" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_CYTK1" name="R_CYTK1" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_cmp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_cdp_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_D__LACt2pp" name="R_D_DASH_LACt2pp" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h_p" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_lac__D_p" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_lac__D_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_D__LACtex" name="R_D_DASH_LACtex" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_lac__D_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_lac__D_p" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_DADK" name="R_DADK" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_damp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_dadp_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_DALAt2pp" name="R_DALAt2pp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_ala__D_p" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_p" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_ala__D_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_DAPDC" name="R_DAPDC" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_26dap__M_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_lys__L_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_DAPE" name="R_DAPE" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_26dap__LL_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_26dap__M_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_DASYN160" name="R_DASYN160" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_ctp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pa160_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_cdpdhdecg_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_DASYN161" name="R_DASYN161" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_ctp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pa161_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_cdpdhdec9eg_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_DB4PS" name="R_DB4PS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_ru5p__D_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_db4p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_forBIO_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_DBTS" name="R_DBTS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_dann_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_dtbt_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="3" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_DDPA" name="R_DDPA" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_e4p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pep_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_2dda7p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_DHAD1" name="R_DHAD1" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_23dhmb_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_3mob_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_DHAD2" name="R_DHAD2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_23dhmp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_3mop_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_DHDPRy" name="R_DHDPRy" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_23dhdp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_thdp_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_DHDPS" name="R_DHDPS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_aspsa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_23dhdp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="2" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_DHFR" name="R_DHFR" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_dhf_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_thf_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_DHFS" name="R_DHFS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_dhpt_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_dhf_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_DHNPA2r" name="R_DHNPA2r" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_dhnpt_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_6hmhpt_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_gcald_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_DHORDfum" name="R_DHORDfum" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_dhor__S_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_fum_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_orot_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_succ_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_DHORTS" name="R_DHORTS" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_dhor__S_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_cbasp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_DHPPDA2" name="R_DHPPDA2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_25drapp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_5apru_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nh4_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_DHPS2" name="R_DHPS2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_4abz_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_6hmhptpp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_dhpt_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_DHPTDCs2" name="R_DHPTDCs2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_dhptd_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_mdhdhf_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_DHQS" name="R_DHQS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_2dda7p_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_3dhq_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_DHQTi" name="R_DHQTi" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_3dhq_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_3dhsk_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_DMATT" name="R_DMATT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_dmpp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ipdp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_grdp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_DNMPPA" name="R_DNMPPA" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_dhpmp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_dhnpt_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_DNTPPA" name="R_DNTPPA" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_ahdt_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_dhpmp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_DPCOAK" name="R_DPCOAK" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_dpcoa_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_DPR" name="R_DPR" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_2dhp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pant__R_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_DTMPK" name="R_DTMPK" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_dtmp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_dtdp_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_DURIK1" name="R_DURIK1" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_duri_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_dump_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_DURIPP" name="R_DURIPP" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_duri_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_2dr1p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ura_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_DXPRIi" name="R_DXPRIi" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_dxyl5p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_2me4p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_DXPS" name="R_DXPS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_g3p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_dxyl5p_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_E4PD" name="R_E4PD" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_e4p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_4per_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ECOAH1" name="R_ECOAH1" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_3hbcoa_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_b2coa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ECOAH2" name="R_ECOAH2" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_3hhcoa_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_hx2coa_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ECOAH3" name="R_ECOAH3" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_3hocoa_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_oc2coa_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ECOAH4" name="R_ECOAH4" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_3hdcoa_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_dc2coa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ECOAH5" name="R_ECOAH5" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_3hddcoa_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_dd2coa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ECOAH6" name="R_ECOAH6" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_3htdcoa_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_td2coa_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ECOAH7" name="R_ECOAH7" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_3hhdcoa_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_hdd2coa_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_EDA" name="R_EDA" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_2ddg6p_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_g3p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_EDD" name="R_EDD" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_6pgc_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_2ddg6p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_EGMEACPR" name="R_EGMEACPR" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_egmeACP_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_gmeACP_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ENO" name="R_ENO" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_2pg_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pep_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_EPMEACPR" name="R_EPMEACPR" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_epmeACP_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pmeACP_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ETOHtex" name="R_ETOHtex" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_etoh_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_etoh_p" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ETOHtrpp" name="R_ETOHtrpp" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_etoh_p" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_etoh_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_F6PA" name="R_F6PA" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_f6p_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_dha_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_g3p_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_FACOAE120" name="R_FACOAE120" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_ddcacoa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ddca_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_FACOAE160" name="R_FACOAE160" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pmtcoa_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_hdca_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_FACOAE161" name="R_FACOAE161" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_hdcoa_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_hdcea_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_FADRx" name="R_FADRx" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_fad_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_fadh2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_FBA" name="R_FBA" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_fdp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_dhap_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_g3p_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_FBP" name="R_FBP" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_fdp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_f6p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_FCLT" name="R_FCLT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_fe2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ppp9_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_pheme_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_FE2tex" name="R_FE2tex" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_fe2_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_fe2_p" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_FE2tpp" name="R_FE2tpp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_fe2_p" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_fe2_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_FE3abcpp" name="R_FE3abcpp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_fe3_p" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_fe3_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_FE3tex" name="R_FE3tex" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_fe3_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_fe3_p" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_FHL" name="R_FHL" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_for_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_FLDR2" name="R_FLDR2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_flxso_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_flxr_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_FMNAT" name="R_FMNAT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_fmn_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_fad_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_FORtex" name="R_FORtex" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_for_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_for_p" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_FORtppi" name="R_FORtppi" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_for_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_for_p" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_FRD2" name="R_FRD2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_fum_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_mql8_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_mqn8_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_succ_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_FRD3" name="R_FRD3" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_2dmmql8_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_fum_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_2dmmq8_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_succ_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_FTHFLi" name="R_FTHFLi" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_thf_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_forBIO_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_10fthf_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_FUM" name="R_FUM" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_fum_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_mal__L_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_G1PACT" name="R_G1PACT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_accoa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_gam1p_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_acgam1p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_G1SAT" name="R_G1SAT" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_glu1sa_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_5aop_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_G3PD2" name="R_G3PD2" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_glyc3p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_dhap_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_G3PD5" name="R_G3PD5" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_glyc3p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_q8_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_dhap_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_q8h2_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_G5SADs" name="R_G5SADs" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_glu5sa_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_1pyr5c_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_G5SD" name="R_G5SD" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_glu5p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_glu5sa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_G6PDH2r" name="R_G6PDH2r" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_g6p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_6pgl_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_GAPD" name="R_GAPD" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_g3p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_13dpg_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_GARFT" name="R_GARFT" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_10fthf_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_gar_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_fgam_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_thf_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_GCALDD" name="R_GCALDD" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_gcald_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_glyclt_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_GF6PTA" name="R_GF6PTA" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_f6p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_gln__L_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_gam6p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_GHMT2r" name="R_GHMT2r" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_ser__L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_thf_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_gly_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_mlthf_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_GK1" name="R_GK1" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_gmp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_gdp_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_GLCptspp" name="R_GLCptspp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_pep_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_glc__D_p" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_g6p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_GLCt2pp" name="R_GLCt2pp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_glc__D_p" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_p" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_glc__D_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_GLCtex" name="R_GLCtex" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_glc__D_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_glc__D_p" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_GLNS" name="R_GLNS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nh4_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_gln__L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_GLU5K" name="R_GLU5K" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_glu5p_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_GLUDy" name="R_GLUDy" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_akg_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nh4_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_GLUPRT" name="R_GLUPRT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_gln__L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_prpp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pram_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_GLUR" name="R_GLUR" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_glu__D_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_GLUTRR" name="R_GLUTRR" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_glutrna_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_glu1sa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_trnaglu_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_GLUTRS" name="R_GLUTRS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_trnaglu_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_amp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_glutrna_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_GLXCL" name="R_GLXCL" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_glxBIO_c" stoichiometry="2" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_2h3oppan_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_GLYCDx" name="R_GLYCDx" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_glyc_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_dha_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_GLYCK" name="R_GLYCK" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_glyc__R_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_3pg_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_GLYCL" name="R_GLYCL" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_gly_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_thf_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_mlthf_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nh4_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_GLYCTO4" name="R_GLYCTO4" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_2dmmq8_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_glyclt_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_2dmmql8_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_glxBIO_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_GLYCtex" name="R_GLYCtex" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_glyc_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_glyc_p" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_GLYCtpp" name="R_GLYCtpp" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_glyc_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_glyc_p" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_GLYK" name="R_GLYK" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_glyc_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_glyc3p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_GLYOX3" name="R_GLYOX3" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_mthgxl_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_lac__D_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_GMPS2" name="R_GMPS2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_gln__L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_xmp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_amp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_gmp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_GND" name="R_GND" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_6pgc_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ru5p__D_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_GRTT" name="R_GRTT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_grdp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ipdp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_frdp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_GRXR" name="R_GRXR" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_grxox_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_gthrd_c" stoichiometry="2" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_grxrd_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_gthox_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_GTHOr" name="R_GTHOr" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_gthox_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_gthrd_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_GTPCI" name="R_GTPCI" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_gtp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_ahdt_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_forBIO_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_GTPCII2" name="R_GTPCII2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_gtp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="3" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_25drapp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_forBIO_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_H2Otex" name="R_H2Otex" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h2o_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h2o_p" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_H2Otpp" name="R_H2Otpp" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h2o_p" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_H2tex" name="R_H2tex" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h2_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h2_p" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_H2tpp" name="R_H2tpp" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h2_p" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h2_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_HACD1" name="R_HACD1" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_aacoa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_3hbcoa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_HACD2" name="R_HACD2" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_3ohcoa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_3hhcoa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_HACD3" name="R_HACD3" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_3oocoa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_3hocoa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_HACD4" name="R_HACD4" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_3odcoa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_3hdcoa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_HACD5" name="R_HACD5" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_3oddcoa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_3hddcoa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_HACD6" name="R_HACD6" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_3otdcoa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_3htdcoa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_HACD7" name="R_HACD7" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_3ohdcoa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_3hhdcoa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_HBZOPT" name="R_HBZOPT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_4hbz_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_octdp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_3ophb_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_HCO3E" name="R_HCO3E" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_hco3_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_HEX1" name="R_HEX1" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_glc__D_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_g6p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_HISTD" name="R_HISTD" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_histd_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nad_c" stoichiometry="2" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h_c" stoichiometry="3" constant="true"/>
+          <speciesReference species="M_his__L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadh_c" stoichiometry="2" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_HISTP" name="R_HISTP" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_hisp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_histd_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_HMBS" name="R_HMBS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ppbng_c" stoichiometry="4" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_hmbil_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nh4_c" stoichiometry="4" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_HPPK2" name="R_HPPK2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_6hmhpt_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_6hmhptpp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_amp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_HSDy" name="R_HSDy" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_hom__L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_aspsa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_HSK" name="R_HSK" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_hom__L_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_phom_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_HSST" name="R_HSST" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_hom__L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_succoa_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_suchms_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_HSTPT" name="R_HSTPT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_imacp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_akg_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_hisp_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_Htex" name="R_Htex" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h_p" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_I2FE2SR" name="R_I2FE2SR" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_2fe1s_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_iscssh_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_iscu_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h_c" stoichiometry="4" constant="true"/>
+          <speciesReference species="M_iscs_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_iscu__2fe2s_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_I2FE2SS" name="R_I2FE2SS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_fadh2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_fe2_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_iscssh_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_iscu_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_fad_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="6" constant="true"/>
+          <speciesReference species="M_iscs_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_iscu__2fe2s_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_I2FE2SS2" name="R_I2FE2SS2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_fadh2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_fe2_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_iscssh_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_iscu__2fe2s_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_fad_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="6" constant="true"/>
+          <speciesReference species="M_iscs_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_iscu__2fe2s2_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_I2FE2ST" name="R_I2FE2ST" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h_c" stoichiometry="4" constant="true"/>
+          <speciesReference species="M_iscu__2fe2s_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_2fe2s_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_iscu_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_I4FE4SR" name="R_I4FE4SR" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_fadh2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_iscu__2fe2s2_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_fad_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_iscu__4fe4s_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_I4FE4ST" name="R_I4FE4ST" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h_c" stoichiometry="4" constant="true"/>
+          <speciesReference species="M_iscu__4fe4s_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_4fe4s_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_iscu_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ICDHyr" name="R_ICDHyr" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_icit_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_akg_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ICL" name="R_ICL" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_icit_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_glx_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_succ_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ICYSDS" name="R_ICYSDS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_cys__L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_iscs_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_ala__L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_iscssh_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_IG3PS" name="R_IG3PS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_gln__L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_prlp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_aicar_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_eig3p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_IGPDH" name="R_IGPDH" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_eig3p_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_imacp_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_IGPS" name="R_IGPS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_2cpr5p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_3ig3p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ILETA" name="R_ILETA" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_akg_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ile__L_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_3mop_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_IMPC" name="R_IMPC" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_imp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_fprica_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_IMPD" name="R_IMPD" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_imp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_xmp_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_IPDDI" name="R_IPDDI" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_ipdp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_dmpp_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_IPDPS" name="R_IPDPS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2mb4p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ipdp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_IPMD" name="R_IPMD" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_3c2hmp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_3c4mop_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_IPPMIa" name="R_IPPMIa" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_3c2hmp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_2ippm_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_IPPMIb" name="R_IPPMIb" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_2ippm_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_3c3hmp_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_IPPS" name="R_IPPS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_3mob_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_accoa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_3c3hmp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_K2L4Aabcpp" name="R_K2L4Aabcpp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_kdo2lipid4_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_kdo2lipid4_p" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_K2L4Aabctex" name="R_K2L4Aabctex" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_kdo2lipid4_p" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_kdo2lipid4_e" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_KARA1" name="R_KARA1" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_23dhmb_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_alac__S_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_KARA2" name="R_KARA2" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_2ahbut_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_23dhmp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_KDOCT2" name="R_KDOCT2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_ctp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_kdo_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_ckdo_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_KDOPP" name="R_KDOPP" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_kdo8p_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_kdo_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_KDOPS" name="R_KDOPS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_ara5p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pep_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_kdo8p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_Kt2pp" name="R_Kt2pp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h_p" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_k_p" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_k_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_Ktex" name="R_Ktex" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_k_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_k_p" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_LDH_D" name="R_LDH_D" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_lac__D_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_LEUTAi" name="R_LEUTAi" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_4mop_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_akg_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_leu__L_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_LPADSS" name="R_LPADSS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_lipidX_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_u23ga_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_lipidAds_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_udp_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_MALCOAMT" name="R_MALCOAMT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_amet_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_malcoa_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_ahcys_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_malcoame_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_MALS" name="R_MALS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_accoa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_glx_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_mal__L_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_MCOATA" name="R_MCOATA" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_ACP_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_malcoa_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_malACP_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_MCTP1App" name="R_MCTP1App" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_murein5p5p_p" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_ala__D_p" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_murein5px4p_p" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_MDH" name="R_MDH" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_mal__L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_oaa_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ME1" name="R_ME1" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_mal__L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ME2" name="R_ME2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_mal__L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_MECDPDH5" name="R_MECDPDH5" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_2mecdp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_flxr_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_flxso_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_h2mb4p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_MECDPS" name="R_MECDPS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_2p4c2me_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_2mecdp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_cmp_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_MEOHtex" name="R_MEOHtex" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_meoh_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_meoh_p" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_MEOHtrpp" name="R_MEOHtrpp" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_meoh_p" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_meoh_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_MEPCT" name="R_MEPCT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_2me4p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ctp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_4c2me_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_METAT" name="R_METAT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_met__L_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_amet_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_METS" name="R_METS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_5mthf_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_hcys__L_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_met__L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_thf_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_MG2t3_2pp" name="R_MG2t3_2pp" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_mg2_p" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_mg2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_p" stoichiometry="2" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_MG2tex" name="R_MG2tex" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_mg2_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_mg2_p" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_MGSA" name="R_MGSA" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_dhap_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_mthgxl_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_MN2tpp" name="R_MN2tpp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_mn2_p" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_mn2_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_MNtex" name="R_MNtex" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_mn2_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_mn2_p" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_MOADSUx" name="R_MOADSUx" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_iscssh_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_moadamp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_amp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_iscs_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_moadcosh_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_MOAT" name="R_MOAT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_ckdo_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_lipidA_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_cmp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_kdolipid4_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_MOAT2" name="R_MOAT2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_ckdo_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_kdolipid4_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_cmp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_kdo2lipid4_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_MOBDabcpp" name="R_MOBDabcpp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_mobd_p" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_mobd_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_MOBDtex" name="R_MOBDtex" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_mobd_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_mobd_p" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_MOCOS" name="R_MOCOS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_mobd_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_mptamp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_amp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_cu2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_moco_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_MOHMT" name="R_MOHMT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_3mob_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_mlthf_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_2dhp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_thf_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_MPTAT" name="R_MPTAT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_mpt_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_mptamp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_MPTG" name="R_MPTG" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_uaagmda_c" stoichiometry="2" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_udcpdp_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_murein5p5p_p" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_MPTS" name="R_MPTS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_cpmp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_cu2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_moadcosh_c" stoichiometry="2" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h_c" stoichiometry="5" constant="true"/>
+          <speciesReference species="M_moadcoo_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_mpt_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_MPTSS" name="R_MPTSS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_moadcoo_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_moadamp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_MTHFC" name="R_MTHFC" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_methf_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_10fthf_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_MTHFD" name="R_MTHFD" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_mlthf_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_methf_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_MTHFR2" name="R_MTHFR2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_mlthf_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_5mthf_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_MTHTHFSs" name="R_MTHTHFSs" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_mdhdhf_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_mththf_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_NADH16pp" name="R_NADH16pp" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h_c" stoichiometry="4" constant="true"/>
+          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_q8_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_q8h2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_p" stoichiometry="3" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_NADH17pp" name="R_NADH17pp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h_c" stoichiometry="4" constant="true"/>
+          <speciesReference species="M_mqn8_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_mql8_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_p" stoichiometry="3" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_NADK" name="R_NADK" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_NADS1" name="R_NADS1" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_dnad_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nh4_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_amp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_NADTRHD" name="R_NADTRHD" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_NDPK1" name="R_NDPK1" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_gdp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_gtp_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_NDPK2" name="R_NDPK2" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_udp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_utp_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_NDPK3" name="R_NDPK3" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_cdp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ctp_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_NDPK4" name="R_NDPK4" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_dtdp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_dttp_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_NDPK8" name="R_NDPK8" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_dadp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_datp_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_NH4tex" name="R_NH4tex" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_nh4_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_nh4_p" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_NH4tpp" name="R_NH4tpp" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_nh4_p" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_nh4_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_NI2tex" name="R_NI2tex" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_ni2_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_ni2_p" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_NI2tpp" name="R_NI2tpp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_ni2_p" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_ni2_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_NNATr" name="R_NNATr" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nicrnt_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_dnad_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_NNDPR" name="R_NNDPR" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_prpp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_quln_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nicrnt_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_NTD2" name="R_NTD2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ump_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_uri_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_NTD6" name="R_NTD6" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_damp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_dad__2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_O2tex" name="R_O2tex" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_o2_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_o2_p" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_O2tpp" name="R_O2tpp" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_o2_p" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_o2_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_OCBT" name="R_OCBT" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_cbp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_orn_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_citr__L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_OCTDPS" name="R_OCTDPS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_frdp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ipdp_c" stoichiometry="5" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_octdp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ppi_c" stoichiometry="5" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_OGMEACPD" name="R_OGMEACPD" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_hgmeACP_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_egmeACP_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_OGMEACPR" name="R_OGMEACPR" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ogmeACP_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_hgmeACP_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_OGMEACPS" name="R_OGMEACPS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_malACP_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_malcoame_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ogmeACP_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_OHPBAT" name="R_OHPBAT" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ohpb_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_akg_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_phthr_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_OMCDC" name="R_OMCDC" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_3c4mop_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_4mop_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_OMPDC" name="R_OMPDC" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_orot5p_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ump_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_OPHBDC" name="R_OPHBDC" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_3ophb_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_2oph_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_OPHHX3" name="R_OPHHX3" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_2oph_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_atp_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="3" constant="true"/>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_2ohph_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_adp_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="3" constant="true"/>
+          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="2" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_OPMEACPD" name="R_OPMEACPD" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_hpmeACP_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_epmeACP_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_OPMEACPR" name="R_OPMEACPR" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_opmeACP_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_hpmeACP_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_OPMEACPS" name="R_OPMEACPS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_gmeACP_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_malACP_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_ACP_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_opmeACP_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ORPT" name="R_ORPT" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_orot5p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_orot_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_prpp_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_P5CR" name="R_P5CR" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_1pyr5c_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pro__L_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PANTS" name="R_PANTS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_ala__B_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pant__R_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_amp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pnto__R_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PAPPT3" name="R_PAPPT3" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_udcpp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ugmda_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_uagmda_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ump_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PAPSR2" name="R_PAPSR2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_grxrd_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_paps_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_grxox_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_pap_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_so3_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PDH" name="R_PDH" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_accoa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PDX5PO2" name="R_PDX5PO2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pdx5p_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pydx5p_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PDX5PS" name="R_PDX5PS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_dxyl5p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_phthr_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pdx5p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PE160abcpp" name="R_PE160abcpp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pe160_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pe160_p" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PE161abcpp" name="R_PE161abcpp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pe161_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pe161_p" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PERD" name="R_PERD" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_4per_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ohpb_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PFK" name="R_PFK" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_f6p_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_fdp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PFL" name="R_PFL" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_accoa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_for_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PGAMT" name="R_PGAMT" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_gam1p_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_gam6p_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PGCD" name="R_PGCD" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_3pg_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_3php_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PGI" name="R_PGI" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_g6p_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_f6p_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PGK" name="R_PGK" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_3pg_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_13dpg_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PGL" name="R_PGL" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_6pgl_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_6pgc_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PGM" name="R_PGM" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_2pg_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_3pg_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PHETA1" name="R_PHETA1" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_akg_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_phe__L_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_phpyr_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PIt2rpp" name="R_PIt2rpp" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h_p" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_p" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PItex" name="R_PItex" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_pi_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_pi_p" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PMDPHT" name="R_PMDPHT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_5aprbu_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_4r5au_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PMEACPE" name="R_PMEACPE" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pmeACP_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_meoh_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pimACP_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PMPK" name="R_PMPK" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_4ampm_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_2mahmp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PNTK" name="R_PNTK" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pnto__R_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_4ppan_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_POX" name="R_POX" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_q8_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_ac_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_q8h2_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PPBNGS" name="R_PPBNGS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_5aop_c" stoichiometry="2" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_ppbng_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PPC" name="R_PPC" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pep_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_oaa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PPCDC" name="R_PPCDC" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_4ppcys_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pan4p_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PPCK" name="R_PPCK" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_oaa_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pep_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PPKr" name="R_PPKr" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PPM" name="R_PPM" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_r1p_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_r5p_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PPNCL2" name="R_PPNCL2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_4ppan_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ctp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_cys__L_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_4ppcys_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_cmp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PPND" name="R_PPND" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pphn_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_34hpp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PPNDH" name="R_PPNDH" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pphn_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_phpyr_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PPPGO3" name="R_PPPGO3" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_fum_c" stoichiometry="3" constant="true"/>
+          <speciesReference species="M_pppg9_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_ppp9_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_succ_c" stoichiometry="3" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PPS" name="R_PPS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_amp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_pep_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PRAGSr" name="R_PRAGSr" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_gly_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pram_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_gar_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PRAIS" name="R_PRAIS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_fpram_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_air_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PRAIi" name="R_PRAIi" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_pran_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_2cpr5p_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PRAMPC" name="R_PRAMPC" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_prbamp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_prfp_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PRASCSi" name="R_PRASCSi" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_5aizc_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_asp__L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_25aics_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PRATPP" name="R_PRATPP" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_prbatp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_prbamp_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PRFGS" name="R_PRFGS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_fgam_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_gln__L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_fpram_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PRMICI" name="R_PRMICI" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_prfp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_prlp_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PROt2rpp" name="R_PROt2rpp" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h_p" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pro__L_p" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pro__L_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PROt4pp" name="R_PROt4pp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_na1_p" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pro__L_p" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_na1_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pro__L_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PRPPS" name="R_PRPPS" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_r5p_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_amp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_prpp_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PSCVT" name="R_PSCVT" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_pep_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_skm5p_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_3psme_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PSD160" name="R_PSD160" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ps160_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pe160_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PSD161" name="R_PSD161" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ps161_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pe161_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PSERT" name="R_PSERT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_3php_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_akg_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pser__L_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PSP_L" name="R_PSP_L" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pser__L_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ser__L_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PSSA160" name="R_PSSA160" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_cdpdhdecg_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ser__L_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_cmp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ps160_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PSSA161" name="R_PSSA161" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_cdpdhdec9eg_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ser__L_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_cmp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ps161_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PTAr" name="R_PTAr" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_accoa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_actp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PTPATi" name="R_PTPATi" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pan4p_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_dpcoa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PUNP1" name="R_PUNP1" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_adn_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_ade_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_r1p_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PUNP2" name="R_PUNP2" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_dad__2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_2dr1p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ade_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PYK" name="R_PYK" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pep_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PYNP2r" name="R_PYNP2r" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_uri_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_r1p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ura_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_QULNS" name="R_QULNS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_dhap_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_iasp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h2o_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_quln_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_RBFK" name="R_RBFK" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ribflv_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_fmn_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_RBFSa" name="R_RBFSa" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_4r5au_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_db4p_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_dmlz_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_RBFSb" name="R_RBFSb" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_dmlz_c" stoichiometry="2" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_4r5au_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ribflv_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_RHCCE" name="R_RHCCE" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_rhcys_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_dhptd_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_hcys__L_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_RNTR1c2" name="R_RNTR1c2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_flxr_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="2" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_datp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_flxso_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_RNTR2c2" name="R_RNTR2c2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_flxr_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_gtp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="2" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_dgtp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_flxso_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_RNTR3c2" name="R_RNTR3c2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_ctp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_flxr_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="2" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_dctp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_flxso_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_RPE" name="R_RPE" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_ru5p__D_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_xu5p__D_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_RPI" name="R_RPI" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_r5p_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_ru5p__D_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_SADT2" name="R_SADT2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_gtp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_so4_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_aps_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_gdp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_SDPDS" name="R_SDPDS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_sl26da_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_26dap__LL_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_succ_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_SDPTA" name="R_SDPTA" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_akg_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_sl26da_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_sl2a6o_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_SERAT" name="R_SERAT" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_accoa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ser__L_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_acser_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_SHCHD2" name="R_SHCHD2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_dscl_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_scl_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_SHCHF" name="R_SHCHF" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_fe2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_scl_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h_c" stoichiometry="3" constant="true"/>
+          <speciesReference species="M_sheme_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_SHK3Dr" name="R_SHK3Dr" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_3dhsk_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_skm_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_SHKK" name="R_SHKK" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_skm_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_skm5p_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_SHSL1" name="R_SHSL1" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_cys__L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_suchms_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_cyst__L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_succ_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_SO4t2pp" name="R_SO4t2pp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h_p" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_so4_p" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_so4_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_SO4tex" name="R_SO4tex" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_so4_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_so4_p" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_SUCCt2_2pp" name="R_SUCCt2_2pp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h_p" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_succ_p" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_succ_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_SUCCt3pp" name="R_SUCCt3pp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_succ_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_p" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_succ_p" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_SUCCtex" name="R_SUCCtex" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_succ_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_succ_p" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_SUCDi" name="R_SUCDi" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_q8_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_succ_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_fum_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_q8h2_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_SUCOAS" name="R_SUCOAS" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_succ_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_succoa_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_SULRi" name="R_SULRi" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h_c" stoichiometry="5" constant="true"/>
+          <speciesReference species="M_nadph_c" stoichiometry="3" constant="true"/>
+          <speciesReference species="M_so3_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h2o_c" stoichiometry="3" constant="true"/>
+          <speciesReference species="M_h2s_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadp_c" stoichiometry="3" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_TALA" name="R_TALA" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_g3p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_s7p_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_e4p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_f6p_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_TDSK" name="R_TDSK" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_lipidAds_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_lipidA_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_THD2pp" name="R_THD2pp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_p" stoichiometry="2" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_THDPS" name="R_THDPS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_succoa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_thdp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_sl2a6o_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_THRD_L" name="R_THRD_L" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_thr__L_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_2obut_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nh4_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_THRS" name="R_THRS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_phom_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_thr__L_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_THZPSN3" name="R_THZPSN3" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_dhgly_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_dxyl5p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_iscssh_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_4mpetz_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_amp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_iscs_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_TKT1" name="R_TKT1" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_r5p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_xu5p__D_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_g3p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_s7p_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_TKT2" name="R_TKT2" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_e4p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_xu5p__D_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_f6p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_g3p_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_TMDS" name="R_TMDS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_dump_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_mlthf_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_dhf_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_dtmp_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_TMPK" name="R_TMPK" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_thmmp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_thmpp_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_TMPPP" name="R_TMPPP" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_2mahmp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_4mpetz_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_thmmp_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_TPI" name="R_TPI" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_dhap_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_g3p_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_TRPAS2" name="R_TRPAS2" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_trp__L_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_indole_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nh4_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_TRPS3" name="R_TRPS3" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_3ig3p_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_g3p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_indole_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_TRSARr" name="R_TRSARr" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_2h3oppan_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_glyc__R_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_TYRL" name="R_TYRL" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_amet_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_tyr__L_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_4crsol_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_dad__5_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_dhgly_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_met__L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_TYRTA" name="R_TYRTA" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_akg_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_tyr__L_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_34hpp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_U23GAAT" name="R_U23GAAT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_3hmrsACP_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_u3hga_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_ACP_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_u23ga_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_UAAGDS" name="R_UAAGDS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_26dap__M_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_uamag_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ugmd_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_UAGAAT" name="R_UAGAAT" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_3hmrsACP_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_uacgam_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_ACP_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_u3aga_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_UAGCVT" name="R_UAGCVT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_pep_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_uacgam_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_uaccg_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_UAGDP" name="R_UAGDP" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_acgam1p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_utp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_uacgam_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_UAGPT3" name="R_UAGPT3" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_uacgam_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_uagmda_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_uaagmda_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_udp_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_UAMAGS" name="R_UAMAGS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_glu__D_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_uama_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_uamag_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_UAMAS" name="R_UAMAS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_ala__L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_uamr_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_uama_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_UAPGR" name="R_UAPGR" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_uaccg_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_uamr_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_UDCPDP" name="R_UDCPDP" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_udcpdp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_udcpp_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_UDCPDPS" name="R_UDCPDPS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_frdp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ipdp_c" stoichiometry="8" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_ppi_c" stoichiometry="8" constant="true"/>
+          <speciesReference species="M_udcpdp_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_UGMDDS" name="R_UGMDDS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_alaala_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ugmd_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ugmda_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_UHGADA" name="R_UHGADA" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_u3aga_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_ac_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_u3hga_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_UMPK" name="R_UMPK" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ump_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_udp_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_UPP3MT" name="R_UPP3MT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_amet_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_uppg3_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_ahcys_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_dscl_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_UPP3S" name="R_UPP3S" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_hmbil_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_uppg3_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_UPPDC1" name="R_UPPDC1" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h_c" stoichiometry="4" constant="true"/>
+          <speciesReference species="M_uppg3_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_co2_c" stoichiometry="4" constant="true"/>
+          <speciesReference species="M_cpppg3_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_USHD" name="R_USHD" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_u23ga_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_lipidX_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ump_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_VALTA" name="R_VALTA" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_akg_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_val__L_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_3mob_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_VPAMTr" name="R_VPAMTr" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_3mob_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ala__L_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_val__L_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ZN2tpp" name="R_ZN2tpp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_zn2_p" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_zn2_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_Zn2tex" name="R_Zn2tex" reversible="true" fast="false" fbc:lowerFluxBound="minus_inf" fbc:upperFluxBound="plus_inf">
+        <listOfReactants>
+          <speciesReference species="M_zn2_e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_zn2_p" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+    </listOfReactions>
+    <fbc:listOfObjectives fbc:activeObjective="obj">
+      <fbc:objective fbc:id="obj" fbc:type="maximize">
+        <fbc:listOfFluxObjectives>
+          <fbc:fluxObjective fbc:reaction="R_Ec_biomass_iJO1366_core_53p95M" fbc:coefficient="1"/>
+        </fbc:listOfFluxObjectives>
+      </fbc:objective>
+    </fbc:listOfObjectives>
+  </model>
+</sbml>
diff --git a/ECC2comp/box_positions.json b/ECC2comp/box_positions.json
index 266ff9d..eec8fdb 100644
--- a/ECC2comp/box_positions.json
+++ b/ECC2comp/box_positions.json
@@ -1,343 +1 @@
-{
-    "Core Metabolism": {
-        "name": "Map",
-        "background": "map1.svg",
-        "bg-size": 1.9999999999999998,
-        "box-size": 1,
-        "zoom": -6,
-        "pos": [
-            0,
-            2
-        ],
-        "boxes": {
-            "GlcUp": [
-                166.4194590317132,
-                103.1267066163677
-            ],
-            "GLCptspp": [
-                420.51461380446653,
-                56.674879841782015
-            ],
-            "GLCt2pp": [
-                322.93124474092826,
-                127.92114270445839
-            ],
-            "HEX1": [
-                587.7503520284749,
-                116.09552362845176
-            ],
-            "G6PDH2r": [
-                849.9460237431543,
-                70.70107297778294
-            ],
-            "PGL": [
-                1039.2079551031634,
-                69.70107297778294
-            ],
-            "F6PA": [
-                496.70335268552014,
-                286.29771627774994
-            ],
-            "PGI": [
-                726.5038112782596,
-                176.63018887467717
-            ],
-            "GND": [
-                1157.8211997573917,
-                190.42833909156678
-            ],
-            "PFK": [
-                620.9167597600324,
-                309.92756228623927
-            ],
-            "FBP": [
-                736.2449507653714,
-                304.75653009690586
-            ],
-            "RPE": [
-                1093.5715881600554,
-                307.9845730160172
-            ],
-            "RPI": [
-                1196.1586396782825,
-                311.2126159351285
-            ],
-            "GLYCDx": [
-                373.9183133706874,
-                442.39596788713493
-            ],
-            "FBA": [
-                602.2896417324763,
-                385.37439920891
-            ],
-            "TKT2": [
-                821.2048842560425,
-                416.1417318320227
-            ],
-            "TKT1": [
-                1091.8566418089445,
-                389.7734743173548
-            ],
-            "TALA": [
-                1089.7996310791666,
-                486.01846145691513
-            ],
-            "TPI": [
-                583.5485022453645,
-                469.1633005102476
-            ],
-            "G3PD2": [
-                535.04003013514,
-                607.7457275706989
-            ],
-            "G3PD5": [
-                429.1941181040246,
-                604.4298563280329
-            ],
-            "GLYK": [
-                448.1633005102476,
-                709.0169078462601
-            ],
-            "GlycUp": [
-                192.81836074850358,
-                764.1637474167575
-            ],
-            "PGK": [
-                732.9552726587062,
-                677.7626717911479
-            ],
-            "GAPD": [
-                733.8412511991506,
-                563.4344807858089
-            ],
-            "PGM": [
-                730.8982619289285,
-                788.8058091475978
-            ],
-            "ENO": [
-                734.1263048480398,
-                876.5947104489354
-            ],
-            "EDA": [
-                1246.8335195200648,
-                708.5870151440384
-            ],
-            "EDD": [
-                1354.721432687901,
-                138.47421735518074
-            ],
-            "Growth": [
-                1608.5739944449488,
-                647.2084037037548
-            ],
-            "h_pEx": [
-                1701.5761762436425,
-                710.9290795227055
-            ],
-            "h2oEx": [
-                1702.804219162754,
-                756.5515730924856
-            ],
-            "CO2Up": [
-                1708.1462835414209,
-                802.06004520271
-            ],
-            "CO2Ex": [
-                1708.2032942711987,
-                834.8843885556005
-            ],
-            "PPC": [
-                599.0948803299093,
-                927.0570022499734
-            ],
-            "PPCK": [
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diff --git a/ECC2comp/map1.svg b/ECC2comp/map1.svg
index 81c58b5..fd612fa 100644
--- a/ECC2comp/map1.svg
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diff --git a/ECC2comp/meta.json b/ECC2comp/meta.json
index fd979c2..d40b79c 100644
--- a/ECC2comp/meta.json
+++ b/ECC2comp/meta.json
@@ -1 +1 @@
-{"description": "EColiCore2 compressed\nMetabolic core model of Escherichia coli str. K-12 substr. MG1655. Compressed  version of EColiCore2 obtained from MATLAB CellNetAnalyzer function CNAcompressMFNetwork\n\nContains:\n94 metabolites\n122 reactions\n\nPublication:\nH\u00e4dicke, O., Klamt, S. EColiCore2: a reference network model of the central metabolism of Escherichia coli and relationships to its genome-scale parent model. Sci Rep 7, 39647 (2017). https://doi.org/10.1038/srep39647", "format version": 1}
\ No newline at end of file
+{"description": "Compressed ECC2 model (https://doi.org/10.1038/srep39647) with annotations from iJO1366 (https://doi.org/10.1038/msb.2011.65) and dG0 from eQuilibrator (https://doi.org/10.1093/nar/gkab1106) @ standard settings (pH 7.5 in cytosol, 7.0 elsewhere, and standard ionic strength of 250 mM and pMg of 2.5, and potential differences between compartments of -0.15 V).", "format version": 2}
\ No newline at end of file
diff --git a/ECC2comp/model.sbml b/ECC2comp/model.sbml
index b324070..306144d 100644
--- a/ECC2comp/model.sbml
+++ b/ECC2comp/model.sbml
@@ -11,104 +11,3015 @@
       </unitDefinition>
     </listOfUnitDefinitions>
     <listOfCompartments>
-      <compartment id="External_Species" constant="true"/>
-      <compartment id="Internal_Species" constant="true"/>
+      <compartment id="Biomass" constant="true"/>
+      <compartment id="c" constant="true"/>
+      <compartment id="e" constant="true"/>
+      <compartment id="p" constant="true"/>
     </listOfCompartments>
     <listOfSpecies>
-      <species id="M_Biomass" name="Biomass" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_13dpg_c" name="3-Phospho-D-glyceroylphosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_2ddg6p_c" name="2-Dehydro-3-deoxy-D-gluconate6-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_2pg_c" name="D-Glycerate2-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_3pg_c" name="3-Phospho-D-glycerate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_4CRSOL_ex" name="M_4CRSOL_ex" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_5DRIB_ex" name="M_5DRIB_ex" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_6pgc_c" name="6-Phospho-D-gluconate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_6pgl_c" name="6-phospho-D-glucono-1,5-lactone" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_ac_c" name="Acetate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_ac_ex" name="M_ac_ex" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_acald_c" name="Acetaldehyde" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_accoa_c" name="Acetyl-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_acon_DASH_C_c" name="cis-Aconitate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_actp_c" name="Acetylphosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_adp_c" name="ADP" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_akg_c" name="2-Oxoglutarate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_AMOB_ex" name="M_AMOB_ex" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_amp_c" name="AMP" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_atp_c" name="ATP" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_ca2_ex" name="M_ca2_ex" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_cit_c" name="Citrate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_cl_ex" name="M_cl_ex" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_co2_c" name="CO2" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_co2_ex" name="M_co2_ex" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_coa_c" name="CoenzymeA" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_cobalt2_ex" name="M_cobalt2_ex" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_cu2_ex" name="M_cu2_ex" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_dha_c" name="Dihydroxyacetone" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_dhap_c" name="Dihydroxyacetonephosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_e4p_c" name="D-Erythrose4-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_etoh_c" name="Ethanol" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_etoh_ex" name="M_etoh_ex" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_f6p_c" name="D-Fructose6-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_fdp_c" name="D-Fructose1,6-bisphosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_fe2_ex" name="M_fe2_ex" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_fe3_ex" name="M_fe3_ex" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_for_c" name="Formate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
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-      <species id="M_fum_c" name="Fumarate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_g3p_c" name="Glyceraldehyde3-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
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-      <species id="M_glc_DASH_D_c" name="D-Glucose" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_glc_DASH_D_ex" name="M_glc_DASH_D_ex" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
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-      <species id="M_glx_c" name="Glyoxylate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_glyc_c" name="Glycerol" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
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-      <species id="M_glyc3p_c" name="Glycerol3-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_h_c" name="H+" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_h_ex" name="M_h_ex" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_h_p" name="H+" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_h2_c" name="H2" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_h2_ex" name="M_h2_ex" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
-      <species id="M_h2o_c" name="H2O" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
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-      <species id="M_icit_c" name="Isocitrate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
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-      <species id="M_zn2_ex" name="M_zn2_ex" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_Biomass" name="Biomass" compartment="Biomass" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species metaid="meta_M_13dpg_c" sboTerm="SBO:0000247" id="M_13dpg_c" name="3-Phospho-D-glyceroyl phosphate" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
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+      <species metaid="meta_M_2ddg6p_c" sboTerm="SBO:0000247" id="M_2ddg6p_c" name="2-Dehydro-3-deoxy-D-gluconate 6-phosphate" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
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+      <species id="M_5DRIB_e" name="M_5DRIB_ex" compartment="e" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species metaid="meta_M_6pgc_c" sboTerm="SBO:0000247" id="M_6pgc_c" name="6-Phospho-D-gluconate" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
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+        <annotation>
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+                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00059"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.drug/D05963"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM58"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.compound/174375"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00048"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+      </species>
+      <species metaid="meta_M_succ_c" sboTerm="SBO:0000247" id="M_succ_c" name="Succinate" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
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+            <rdf:Description rdf:about="#meta_M_succ_c">
+              <bqbiol:is>
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+                  <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMFA01170043"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM25"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.compound/389583"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.compound/5278787"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.compound/159939"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.compound/433123"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.compound/29434"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.compound/113536"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/1924"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00036"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+      </species>
+      <species metaid="meta_M_succ_e" sboTerm="SBO:0000247" id="M_succ_e" name="Succinate" compartment="e" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_M_succ_e">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/succ"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:SUC"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:22941"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:26803"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:15741"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:132287"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:45639"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:30779"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:15125"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:22943"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:26807"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:9304"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:90372"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:30031"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/envipath/5882df9c-dae1-4d80-a40e-db4724271456/compound/6377658b-03f6-4fed-a5bf-ff0f2389b693"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/envipath/32de3cf4-e3e6-4168-956e-32fa5ddb0ce1/compound/8fdfd425-4343-4bf2-8427-b2ffa57fdbd7"/>
+                  <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB00254"/>
+                  <rdf:li rdf:resource="https://identifiers.org/inchi_key/KDYFGRWQOYBRFD-UHFFFAOYSA-L"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00042"/>
+                  <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMFA01170043"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM25"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.compound/389583"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.compound/5278787"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.compound/159939"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.compound/433123"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.compound/29434"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.compound/113536"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/1924"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00036"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+      </species>
+      <species metaid="meta_M_succ_p" sboTerm="SBO:0000247" id="M_succ_p" name="Succinate" compartment="p" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_M_succ_p">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/succ"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:SUC"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:22941"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:26803"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:15741"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:132287"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:45639"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:30779"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:15125"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:22943"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:26807"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:9304"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:90372"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:30031"/>
+                  <rdf:li rdf:resource="https://identifiers.org/envipath/4fd7f3e0-dd25-43ac-9453-dda3e52396e4/compound/cc98aff0-7f64-4db4-9d59-de961c228496"/>
+                  <rdf:li rdf:resource="https://identifiers.org/envipath/5882df9c-dae1-4d80-a40e-db4724271456/compound/6377658b-03f6-4fed-a5bf-ff0f2389b693"/>
+                  <rdf:li rdf:resource="https://identifiers.org/envipath/650babc9-9d68-4b73-9332-11972ca26f7b/compound/600b74d3-8fe5-426d-bedf-291175bd23e4"/>
+                  <rdf:li rdf:resource="https://identifiers.org/envipath/32de3cf4-e3e6-4168-956e-32fa5ddb0ce1/compound/8fdfd425-4343-4bf2-8427-b2ffa57fdbd7"/>
+                  <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB00254"/>
+                  <rdf:li rdf:resource="https://identifiers.org/inchi_key/KDYFGRWQOYBRFD-UHFFFAOYSA-L"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00042"/>
+                  <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMFA01170043"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM25"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.compound/389583"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.compound/5278787"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.compound/159939"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.compound/433123"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.compound/29434"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.compound/113536"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/1924"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00036"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+      </species>
+      <species metaid="meta_M_succoa_c" sboTerm="SBO:0000247" id="M_succoa_c" name="Succinyl-CoA" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_M_succoa_c">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/succoa"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:SUC-COA"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:57292"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:10746"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:15127"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:15380"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:9310"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:45541"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:26811"/>
+                  <rdf:li rdf:resource="https://identifiers.org/envipath/32de3cf4-e3e6-4168-956e-32fa5ddb0ce1/compound/359075fb-98d9-458d-ba82-db4020e753f3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB01022"/>
+                  <rdf:li rdf:resource="https://identifiers.org/inchi_key/VNOYUJKHFWYWIR-ITIYDSSPSA-I"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00091"/>
+                  <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMFA07050370"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM92"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.compound/70958"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/1931"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00078"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+      </species>
+      <species metaid="meta_M_xu5p__D_c" sboTerm="SBO:0000247" id="M_xu5p__D_c" name="D-Xylulose 5-phosphate" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_M_xu5p__D_c">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/xu5p__D"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:XYLULOSE-5-PHOSPHATE"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13036"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:27354"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:4269"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:16332"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:57737"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:21121"/>
+                  <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB06212"/>
+                  <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB00868"/>
+                  <rdf:li rdf:resource="https://identifiers.org/inchi_key/FNZLKVNUWIIPSJ-RFZPGFLSSA-L"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00231"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM186"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.compound/29790"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/1317"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00198"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+      </species>
+      <species metaid="meta_M_zn2_e" sboTerm="SBO:0000247" id="M_zn2_e" name="Zinc" compartment="e" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_M_zn2_e">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/zn2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:ZN+2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:49982"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:49972"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:29105"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:27368"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:10113"/>
+                  <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB01303"/>
+                  <rdf:li rdf:resource="https://identifiers.org/inchi_key/PTFCDOFLOPIGGS-UHFFFAOYSA-N"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00038"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM149"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.compound/216667"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.compound/437093"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.compound/29426"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.compound/216785"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.compound/435350"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.compound/442320"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.compound/158417"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/1281"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00034"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+      </species>
     </listOfSpecies>
     <listOfParameters>
       <parameter sboTerm="SBO:0000626" id="cobra_default_lb" value="-1000" constant="true"/>
@@ -117,11 +3028,11 @@
       <parameter sboTerm="SBO:0000626" id="minus_inf" value="-INF" constant="true"/>
       <parameter sboTerm="SBO:0000626" id="plus_inf" value="INF" constant="true"/>
       <parameter sboTerm="SBO:0000625" id="R_AcUp_upper_bound" value="10" units="mmol_per_gDW_per_hr" constant="true"/>
+      <parameter sboTerm="SBO:0000625" id="R_ATPM_lower_bound" value="3.15" units="mmol_per_gDW_per_hr" constant="true"/>
       <parameter sboTerm="SBO:0000625" id="R_CO2Up_upper_bound" value="10" units="mmol_per_gDW_per_hr" constant="true"/>
       <parameter sboTerm="SBO:0000625" id="R_GlcUp_upper_bound" value="10" units="mmol_per_gDW_per_hr" constant="true"/>
       <parameter sboTerm="SBO:0000625" id="R_GlycUp_upper_bound" value="10" units="mmol_per_gDW_per_hr" constant="true"/>
       <parameter sboTerm="SBO:0000625" id="R_SuccUp_upper_bound" value="10" units="mmol_per_gDW_per_hr" constant="true"/>
-      <parameter sboTerm="SBO:0000625" id="R_ATPM_lower_bound" value="3.15" units="mmol_per_gDW_per_hr" constant="true"/>
     </listOfParameters>
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       <reaction metaid="meta_R_EX_Biomass" sboTerm="SBO:0000627" id="R_EX_Biomass" name="EX_Biomass" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
@@ -129,19 +3040,42 @@
           <speciesReference species="M_Biomass" stoichiometry="1" constant="true"/>
         </listOfReactants>
       </reaction>
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+      <reaction metaid="meta_R_EX_4CRSOL_e" sboTerm="SBO:0000627" id="R_EX_4CRSOL_e" name="EX_4CRSOL_ex" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
         <listOfReactants>
-          <speciesReference species="M_4CRSOL_ex" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_4CRSOL_e" stoichiometry="1" constant="true"/>
         </listOfReactants>
       </reaction>
-      <reaction metaid="meta_R_EX_5DRIB_ex" sboTerm="SBO:0000627" id="R_EX_5DRIB_ex" name="EX_5DRIB_ex" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_EX_5DRIB_e" sboTerm="SBO:0000627" id="R_EX_5DRIB_e" name="EX_5DRIB_ex" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
         <listOfReactants>
-          <speciesReference species="M_5DRIB_ex" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_5DRIB_e" stoichiometry="1" constant="true"/>
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       </reaction>
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+      <reaction metaid="meta_R_EX_ac_e" sboTerm="SBO:0000627" id="R_EX_ac_e" name="Acetate exchange" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
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+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08063"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
-          <speciesReference species="M_ac_ex" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ac_e" stoichiometry="1" constant="true"/>
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@@ -149,24 +3083,405 @@
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+      <reaction metaid="meta_R_EX_AMOB_e" sboTerm="SBO:0000627" id="R_EX_AMOB_e" name="EX_AMOB_ex" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
         <listOfReactants>
-          <speciesReference species="M_AMOB_ex" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_AMOB_e" stoichiometry="1" constant="true"/>
         </listOfReactants>
       </reaction>
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+      <reaction metaid="meta_R_EX_ca2_e" sboTerm="SBO:0000627" id="R_EX_ca2_e" name="Calcium exchange" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
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+          <speciesReference species="M_co2_e" stoichiometry="1" constant="true"/>
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@@ -174,89 +3489,946 @@
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+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08923"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
-          <speciesReference species="M_mg2_ex" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_mg2_e" stoichiometry="1" constant="true"/>
         </listOfReactants>
       </reaction>
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+      <reaction metaid="meta_R_EX_mn2_e" sboTerm="SBO:0000627" id="R_EX_mn2_e" name="Mn2+ exchange" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_EX_mn2_e">
+              <bqbiol:is>
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+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08947"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
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+        </annotation>
         <listOfReactants>
-          <speciesReference species="M_mn2_ex" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_mn2_e" stoichiometry="1" constant="true"/>
         </listOfReactants>
       </reaction>
-      <reaction metaid="meta_R_EX_mobd_ex" sboTerm="SBO:0000627" id="R_EX_mobd_ex" name="EX_mobd_ex" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_EX_mobd_e" sboTerm="SBO:0000627" id="R_EX_mobd_e" name="Molybdate exchange" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_EX_mobd_e">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/EX_mobd_e"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101690"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/34909"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/34907"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/34910"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/34908"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08956"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
-          <speciesReference species="M_mobd_ex" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_mobd_e" stoichiometry="1" constant="true"/>
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       </reaction>
       <reaction metaid="meta_R_EX_mqn8_c" sboTerm="SBO:0000627" id="R_EX_mqn8_c" name="EX_mqn8_c" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
@@ -264,9 +4436,9 @@
           <speciesReference species="M_mqn8_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
       </reaction>
-      <reaction metaid="meta_R_EX_MTHTHF_ex" sboTerm="SBO:0000627" id="R_EX_MTHTHF_ex" name="EX_MTHTHF_ex" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_EX_MTHTHF_e" sboTerm="SBO:0000627" id="R_EX_MTHTHF_e" name="EX_MTHTHF_ex" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
         <listOfReactants>
-          <speciesReference species="M_MTHTHF_ex" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_MTHTHF_e" stoichiometry="1" constant="true"/>
         </listOfReactants>
       </reaction>
       <reaction metaid="meta_R_EX_nad_c" sboTerm="SBO:0000627" id="R_EX_nad_c" name="EX_nad_c" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
@@ -279,19 +4451,93 @@
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-      <reaction metaid="meta_R_EX_nh4_ex" sboTerm="SBO:0000627" id="R_EX_nh4_ex" name="EX_nh4_ex" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_EX_nh4_e" sboTerm="SBO:0000627" id="R_EX_nh4_e" name="Ammonia exchange" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_EX_nh4_e">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/EX_nh4_e"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN-9615"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:TRANS-RXN0-544"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-444416"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-444416"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-444416"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-444416"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-444416"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-444416"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-444416"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-444416"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-444416"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-444416"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-444416"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-444416"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-444416"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28749"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28748"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28750"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28747"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/11683"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn13364"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09835"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn05466"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08987"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08986"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09736"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
-          <speciesReference species="M_nh4_ex" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nh4_e" stoichiometry="1" constant="true"/>
         </listOfReactants>
       </reaction>
-      <reaction metaid="meta_R_EX_ni2_ex" sboTerm="SBO:0000627" id="R_EX_ni2_ex" name="EX_ni2_ex" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_EX_ni2_e" sboTerm="SBO:0000627" id="R_EX_ni2_e" name="Ni2+ exchange" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_EX_ni2_e">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/EX_ni2_e"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:TRANS-RXN-141B"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101958"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29833"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29831"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29834"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29832"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
-          <speciesReference species="M_ni2_ex" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ni2_e" stoichiometry="1" constant="true"/>
         </listOfReactants>
       </reaction>
-      <reaction metaid="meta_R_EX_o2_ex" sboTerm="SBO:0000627" id="R_EX_o2_ex" name="EX_o2_ex" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_EX_o2_e" sboTerm="SBO:0000627" id="R_EX_o2_e" name="O2 exchange" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_EX_o2_e">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/EX_o2_e"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:TRANS-RXN0-474"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102090"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09641"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn05468"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09031"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09032"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09734"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
-          <speciesReference species="M_o2_ex" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_o2_e" stoichiometry="1" constant="true"/>
         </listOfReactants>
       </reaction>
       <reaction metaid="meta_R_EX_pi_c" sboTerm="SBO:0000627" id="R_EX_pi_c" name="EX_pi_c" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
@@ -299,9 +4545,31 @@
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
       </reaction>
-      <reaction metaid="meta_R_EX_pi_ex" sboTerm="SBO:0000627" id="R_EX_pi_ex" name="EX_pi_ex" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_EX_pi_e" sboTerm="SBO:0000627" id="R_EX_pi_e" name="Phosphate exchange" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_EX_pi_e">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/EX_pi_e"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:TRANS-RXN0-470"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102871"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/32824"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/32826"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/32825"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/32823"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/10985"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn10838"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09722"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09121"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn13178"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
-          <speciesReference species="M_pi_ex" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_e" stoichiometry="1" constant="true"/>
         </listOfReactants>
       </reaction>
       <reaction metaid="meta_R_EX_q8_c" sboTerm="SBO:0000627" id="R_EX_q8_c" name="EX_q8_c" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
@@ -309,19 +4577,212 @@
           <speciesReference species="M_q8_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
       </reaction>
-      <reaction metaid="meta_R_EX_so4_ex" sboTerm="SBO:0000627" id="R_EX_so4_ex" name="EX_so4_ex" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_EX_so4_e" sboTerm="SBO:0000627" id="R_EX_so4_e" name="Sulfate exchange" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_EX_so4_e">
+              <bqbiol:is>
+                <rdf:Bag>
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+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104469"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-8875871"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-8875871"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-8875871"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-8875871"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-8875871"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-8875871"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-8875871"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-8875871"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-8875871"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-8875871"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-8875871"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-8875871"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/34983"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09261"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn05238"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
-          <speciesReference species="M_so4_ex" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_so4_e" stoichiometry="1" constant="true"/>
         </listOfReactants>
       </reaction>
-      <reaction metaid="meta_R_EX_succ_ex" sboTerm="SBO:0000627" id="R_EX_succ_ex" name="EX_succ_ex" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_EX_succ_e" sboTerm="SBO:0000627" id="R_EX_succ_e" name="Succinate exchange" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_EX_succ_e">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/EX_succ_e"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:TRANS-RXN0-552"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104619"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn10952"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09271"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
-          <speciesReference species="M_succ_ex" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_succ_e" stoichiometry="1" constant="true"/>
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+      <reaction metaid="meta_R_EX_zn2_e" sboTerm="SBO:0000627" id="R_EX_zn2_e" name="Zinc exchange" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
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+            <rdf:Description rdf:about="#meta_R_EX_zn2_e">
+              <bqbiol:is>
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+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-442422"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-442393"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-442393"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-437136"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-442422"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-442387"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-437085"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-442393"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-442393"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-437139"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-437085"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-442317"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-442393"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-437136"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-437136"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-437136"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-437085"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-442393"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-437139"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-437085"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-442317"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-437085"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-442387"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-435366"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-442387"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-437139"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-437136"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-442387"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-442422"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-442422"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-435366"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-442387"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-437085"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-442317"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-435366"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-437139"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-437136"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-435366"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-442387"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-442422"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-437136"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-442317"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-442393"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-437139"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-442345"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-442387"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-442317"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-442422"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-437136"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-442319"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-442393"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-437139"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-437136"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-435366"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-437085"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-442387"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-442387"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-435366"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-437085"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-437145"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-442387"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-442393"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-442317"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-442393"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-442422"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-442317"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-437085"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-435366"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-437085"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-437139"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-435375"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-437094"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-437136"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-437136"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-435366"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29353"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29351"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29352"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29354"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/13042"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09391"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09390"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
-          <speciesReference species="M_zn2_ex" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_zn2_e" stoichiometry="1" constant="true"/>
         </listOfReactants>
       </reaction>
       <reaction id="R_Growth" name="Growth" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
@@ -330,58 +4791,81 @@
           <speciesReference species="M_accoa_c" stoichiometry="3.8579" constant="true"/>
           <speciesReference species="M_akg_c" stoichiometry="1.0752" constant="true"/>
           <speciesReference species="M_atp_c" stoichiometry="63.2803" constant="true"/>
-          <speciesReference species="M_ca2_ex" stoichiometry="0.005205" constant="true"/>
-          <speciesReference species="M_cl_ex" stoichiometry="0.005205" constant="true"/>
-          <speciesReference species="M_cobalt2_ex" stoichiometry="2.5e-05" constant="true"/>
-          <speciesReference species="M_cu2_ex" stoichiometry="0.000709" constant="true"/>
+          <speciesReference species="M_ca2_e" stoichiometry="0.005205" constant="true"/>
+          <speciesReference species="M_cl_e" stoichiometry="0.005205" constant="true"/>
+          <speciesReference species="M_cobalt2_e" stoichiometry="2.5e-05" constant="true"/>
+          <speciesReference species="M_cu2_e" stoichiometry="0.000709" constant="true"/>
           <speciesReference species="M_dhap_c" stoichiometry="0.002278" constant="true"/>
           <speciesReference species="M_e4p_c" stoichiometry="0.38135" constant="true"/>
           <speciesReference species="M_f6p_c" stoichiometry="0.094488" constant="true"/>
-          <speciesReference species="M_fe2_ex" stoichiometry="0.008253" constant="true"/>
-          <speciesReference species="M_fe3_ex" stoichiometry="0.007808" constant="true"/>
+          <speciesReference species="M_fe2_e" stoichiometry="0.008253" constant="true"/>
+          <speciesReference species="M_fe3_e" stoichiometry="0.007808" constant="true"/>
           <speciesReference species="M_glyc3p_c" stoichiometry="0.13903" constant="true"/>
           <speciesReference species="M_h_p" stoichiometry="1.4007" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="40.8722" constant="true"/>
-          <speciesReference species="M_k_ex" stoichiometry="0.19519" constant="true"/>
-          <speciesReference species="M_mg2_ex" stoichiometry="0.008675" constant="true"/>
-          <speciesReference species="M_mn2_ex" stoichiometry="0.000691" constant="true"/>
-          <speciesReference species="M_mobd_ex" stoichiometry="0.000129" constant="true"/>
+          <speciesReference species="M_k_e" stoichiometry="0.19519" constant="true"/>
+          <speciesReference species="M_mg2_e" stoichiometry="0.008675" constant="true"/>
+          <speciesReference species="M_mn2_e" stoichiometry="0.000691" constant="true"/>
+          <speciesReference species="M_mobd_e" stoichiometry="0.000129" constant="true"/>
           <speciesReference species="M_nadh_c" stoichiometry="1.8822" constant="true"/>
           <speciesReference species="M_nadph_c" stoichiometry="13.225" constant="true"/>
-          <speciesReference species="M_nh4_ex" stoichiometry="10.8007" constant="true"/>
-          <speciesReference species="M_ni2_ex" stoichiometry="0.000323" constant="true"/>
+          <speciesReference species="M_nh4_e" stoichiometry="10.8007" constant="true"/>
+          <speciesReference species="M_ni2_e" stoichiometry="0.000323" constant="true"/>
           <speciesReference species="M_oaa_c" stoichiometry="2.9276" constant="true"/>
           <speciesReference species="M_pep_c" stoichiometry="0.82896" constant="true"/>
-          <speciesReference species="M_pi_ex" stoichiometry="0.96451" constant="true"/>
+          <speciesReference species="M_pi_e" stoichiometry="0.96451" constant="true"/>
           <speciesReference species="M_pyr_c" stoichiometry="2.8394" constant="true"/>
           <speciesReference species="M_r5p_c" stoichiometry="0.93398" constant="true"/>
-          <speciesReference species="M_ru5p_DASH_D_c" stoichiometry="0.039804" constant="true"/>
-          <speciesReference species="M_so4_ex" stoichiometry="0.25221" constant="true"/>
+          <speciesReference species="M_ru5p__D_c" stoichiometry="0.039804" constant="true"/>
+          <speciesReference species="M_so4_e" stoichiometry="0.25221" constant="true"/>
           <speciesReference species="M_succoa_c" stoichiometry="0.52486" constant="true"/>
-          <speciesReference species="M_zn2_ex" stoichiometry="0.000341" constant="true"/>
+          <speciesReference species="M_zn2_e" stoichiometry="0.000341" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_Biomass" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_4CRSOL_ex" stoichiometry="0.000223" constant="true"/>
-          <speciesReference species="M_5DRIB_ex" stoichiometry="0.000671" constant="true"/>
+          <speciesReference species="M_4CRSOL_e" stoichiometry="0.000223" constant="true"/>
+          <speciesReference species="M_5DRIB_e" stoichiometry="0.000671" constant="true"/>
           <speciesReference species="M_ac_c" stoichiometry="0.58258" constant="true"/>
           <speciesReference species="M_adp_c" stoichiometry="60.6288" constant="true"/>
-          <speciesReference species="M_AMOB_ex" stoichiometry="2e-06" constant="true"/>
+          <speciesReference species="M_AMOB_e" stoichiometry="2e-06" constant="true"/>
           <speciesReference species="M_amp_c" stoichiometry="2.6515" constant="true"/>
           <speciesReference species="M_co2_c" stoichiometry="1.7972" constant="true"/>
           <speciesReference species="M_coa_c" stoichiometry="4.3828" constant="true"/>
           <speciesReference species="M_fum_c" stoichiometry="0.70838" constant="true"/>
           <speciesReference species="M_g3p_c" stoichiometry="0.054008" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="51.2225" constant="true"/>
-          <speciesReference species="M_meoh_ex" stoichiometry="2e-06" constant="true"/>
-          <speciesReference species="M_MTHTHF_ex" stoichiometry="0.000448" constant="true"/>
+          <speciesReference species="M_meoh_e" stoichiometry="2e-06" constant="true"/>
+          <speciesReference species="M_MTHTHF_e" stoichiometry="0.000448" constant="true"/>
           <speciesReference species="M_nad_c" stoichiometry="1.8822" constant="true"/>
           <speciesReference species="M_nadp_c" stoichiometry="13.225" constant="true"/>
           <speciesReference species="M_pi_c" stoichiometry="70.0155" constant="true"/>
           <speciesReference species="M_succ_c" stoichiometry="0.85927" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction id="R_ACALD" name="R_ACALD" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_ACALD" sboTerm="SBO:0000176" id="R_ACALD" name="Acetaldehyde dehydrogenase (acetylating)" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ACALD">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ACALD"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:ACETALD-DEHYDROG-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.2.1.10"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00228"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95210"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23290"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23291"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23289"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23288"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/163"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00171"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/21.176782276804715"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.004080163838370954"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_accoa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
@@ -392,6 +4876,12 @@
           <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b0351"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b1241"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
       </reaction>
       <reaction id="R_AcEx" name="R_AcEx" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
         <listOfReactants>
@@ -399,11 +4889,35 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="M_ac_ex" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ac_e" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_p" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction id="R_ACKr" name="R_ACKr" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_ACKr" sboTerm="SBO:0000176" id="R_ACKr" name="Acetate kinase" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ACKr">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ACKr"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:ACETATEKIN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.2.15"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.2.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00315"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95269"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11354"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11355"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11353"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11352"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/71"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00225"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-15.085335094962488"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/9.620823723037854e-05"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_actp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
@@ -412,24 +4926,83 @@
           <speciesReference species="M_ac_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b3115"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2296"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b1849"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction id="R_ACONTa" name="R_ACONTa" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_ACONTa" sboTerm="SBO:0000176" id="R_ACONTa" name="Aconitase (half-reaction A, Citrate hydro-lyase)" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ACONTa">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ACONTa"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:ACONITATEDEHYDR-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.2.1.3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01325"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95386"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10230"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10229"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10231"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10228"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/268"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00974"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_cit_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="M_acon_DASH_C_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_acon__C_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b0118"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b1276"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction id="R_ACONTb" name="R_ACONTb" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_ACONTb" sboTerm="SBO:0000176" id="R_ACONTb" name="Aconitase (half-reaction B, Isocitrate hydro-lyase)" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ACONTb">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ACONTb"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.2.1.3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01900"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95387"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22145"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22144"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22146"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/22147"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01388"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
-          <speciesReference species="M_acon_DASH_C_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_acon__C_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_icit_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b0118"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b1276"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
       </reaction>
       <reaction metaid="meta_R_AcUp" id="R_AcUp" name="R_AcUp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="R_AcUp_upper_bound">
         <annotation>
@@ -444,7 +5017,7 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="M_ac_ex" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ac_e" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_p" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
@@ -452,7 +5025,66 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction id="R_ADK1" name="R_ADK1" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_ADK1" sboTerm="SBO:0000176" id="R_ADK1" name="Adenylate kinase" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ADK1">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ADK1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:ADENYL-KIN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.4.3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00127"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95450"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-110145"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-110144"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-110144"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-110145"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-110145"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-110144"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-110145"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-110144"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-110145"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-110145"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-110145"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-110144"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-110144"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-110145"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-110144"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-110144"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-110144"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-110145"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-110144"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-110145"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-110144"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-110144"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-110145"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-110144"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-110144"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-110144"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-110145"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-110144"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-110144"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-110145"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-110145"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-110145"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-110145"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-110145"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-110144"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-110145"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12975"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12973"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12976"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12974"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/82"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00097"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/0.14508522869914486"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/5.8192201936177294e-05"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_amp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
@@ -460,8 +5092,56 @@
         <listOfProducts>
           <speciesReference species="M_adp_c" stoichiometry="2" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0474"/>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction id="R_AKGDH" name="R_AKGDH" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_AKGDH" sboTerm="SBO:0000176" id="R_AKGDH" name="2-Oxogluterate dehydrogenase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_AKGDH">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/AKGDH"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:2OXOGLUTARATEDEH-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.2.1.52"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.1.61"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.8.1.4"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.2.4.2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R08549"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95655"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-71401"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-71401"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-71401"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-71401"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-71401"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-71401"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-71401"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-71401"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-71401"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-71401"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-71401"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-373042"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-71401"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-71401"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-71401"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-71401"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-71401"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-71401"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-71401"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27789"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27788"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27786"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27787"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/8163"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08094"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-29.763292890841285"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.009356940213820164"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_akg_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
@@ -472,8 +5152,56 @@
           <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_succoa_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:and>
+            <fbc:geneProductRef fbc:geneProduct="G_b0116"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0726"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0727"/>
+          </fbc:and>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction id="R_ALCD2x" name="R_ALCD2x" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_ALCD2x" sboTerm="SBO:0000176" id="R_ALCD2x" name="Alcohol dehydrogenase (ethanol)" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ALCD2x">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ALCD2x"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:ALCOHOL-DEHYDROG-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.71"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00754"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95725"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-71707"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-71707"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-71707"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-71707"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-71707"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-71707"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-71707"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-71707"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-71707"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-71707"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-71707"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-71707"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-71707"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-71707"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-71707"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-71707"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-71707"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/25292"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/25290"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/25291"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/25293"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/597"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00543"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-18.233991078878717"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.000137354495617803"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_acald_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
@@ -483,8 +5211,108 @@
           <speciesReference species="M_etoh_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b1478"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b1241"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0356"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="meta_R_ATPM" id="R_ATPM" name="R_ATPM" reversible="false" fast="false" fbc:lowerFluxBound="R_ATPM_lower_bound" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_ATPM" sboTerm="SBO:0000176" id="R_ATPM" name="ATP maintenance requirement" reversible="false" fast="false" fbc:lowerFluxBound="R_ATPM_lower_bound" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ATPM">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ATPM"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:ATPASE-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.1.5"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.34"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.20"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.53"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.8"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.32"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.4.12"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.48"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.40"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.9"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.23"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.22"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.54"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.1.8"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.29"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.17"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.50"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.39"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.19"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.4"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.35"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.16"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.4.4"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.37"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.4.8"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.31"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.6"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.4.5"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.52"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.14"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.51"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.25"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.38"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.33"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.43"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.4.10"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.4.13"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.10"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.24"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.44"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.15"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.5"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.1.3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.1.15"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.4.2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.4.3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.42"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.11"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.28"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.30"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.4.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.4.11"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.47"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.4.6"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.36"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.21"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.12"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.18"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.26"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.27"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.7"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.4.9"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.4.7"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.46"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.41"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.49"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00086"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR96131"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13066"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13065"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13068"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13067"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/75"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn11300"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09694"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00062"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-29.218617912453276"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.00047681174402202167"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
@@ -495,7 +5323,25 @@
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction id="R_ATPS4rpp" name="R_ATPS4rpp" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_ATPS4rpp" sboTerm="SBO:0000185" id="R_ATPS4rpp" name="ATP synthase (four protons for one ATP) (periplasm)" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ATPS4rpp">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ATPS4rpp"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:ATPSYN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.14"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR96136"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08173"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn10042"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-40.08227377736068"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.30427785529910184"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_p" stoichiometry="4" constant="true"/>
@@ -506,24 +5352,93 @@
           <speciesReference species="M_h_c" stoichiometry="3" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b3736"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b3737"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b3738"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b3731"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b3732"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b3733"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b3734"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b3735"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b3739"/>
+            </fbc:and>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b3736"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b3737"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b3738"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b3731"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b3732"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b3733"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b3734"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b3735"/>
+            </fbc:and>
+          </fbc:or>
+        </fbc:geneProductAssociation>
       </reaction>
       <reaction id="R_CO2Ex" name="R_CO2Ex" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
         <listOfReactants>
           <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="M_co2_ex" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_co2_e" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
       <reaction id="R_CO2Up" name="R_CO2Up" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="R_CO2Up_upper_bound">
         <listOfReactants>
-          <speciesReference species="M_co2_ex" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_co2_e" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction id="R_CS" name="R_CS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_CS" sboTerm="SBO:0000176" id="R_CS" name="Citrate synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_CS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/CS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:CITSYN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN-14905"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.3.16"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.3.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.3.3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00351"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR96920"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-373006"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-70975"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-70975"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-70975"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-70975"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-70975"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-70975"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-70975"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-70975"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-70975"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-70975"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-70975"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-70975"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-70975"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-70975"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-70975"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-70975"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-70975"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16847"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16846"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16845"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16848"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/267"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00256"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-39.77874012950201"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0005755481893411907"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_accoa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
@@ -534,8 +5449,25 @@
           <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0720"/>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction id="R_CYTBO3_4pp" name="R_CYTBO3_4pp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_CYTBO3_4pp" sboTerm="SBO:0000185" id="R_CYTBO3_4pp" name="Cytochrome oxidase bo3 (ubiquinol-8: 4 protons) (periplasm)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_CYTBO3_4pp">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/CYTBO3_4pp"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97036"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-24.263341267147382"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/6.403534584307678"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h_c" stoichiometry="4" constant="true"/>
           <speciesReference species="M_o2_c" stoichiometry="0.5" constant="true"/>
@@ -546,8 +5478,39 @@
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_q8_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:and>
+            <fbc:geneProductRef fbc:geneProduct="G_b0429"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0430"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0431"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0432"/>
+          </fbc:and>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction id="R_EDA" name="R_EDA" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_EDA" sboTerm="SBO:0000176" id="R_EDA" name="2-dehydro-3-deoxy-phosphogluconate aldolase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_EDA">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/EDA"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:KDPGALDOL-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.1.2.14"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.1.2.55"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R05605"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97897"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17092"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17091"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17089"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17090"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn03884"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/16.161247186289074"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/4.28650170913869e-15"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_2ddg6p_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
@@ -555,8 +5518,33 @@
           <speciesReference species="M_g3p_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b1850"/>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction id="R_EDD" name="R_EDD" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_EDD" sboTerm="SBO:0000176" id="R_EDD" name="6-phosphogluconate dehydratase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_EDD">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/EDD"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:PGLUCONDEHYDRAT-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.2.1.12"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R02036"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97898"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17280"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17278"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17277"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17279"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01477"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-42.92921777308186"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.003835339539805975"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_6pgc_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
@@ -564,8 +5552,72 @@
           <speciesReference species="M_2ddg6p_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b1851"/>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction id="R_ENO" name="R_ENO" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_ENO" sboTerm="SBO:0000176" id="R_ENO" name="Enolase" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ENO">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ENO"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:2PGADEHYDRAT-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.2.1.11"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00658"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97932"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-71660"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-70494"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-71660"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-71660"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-352981"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-70494"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-70494"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-70494"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-71660"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-353044"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-71660"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-70494"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-71660"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-71660"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-70494"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-70494"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-71660"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-70494"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-70494"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-70494"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-70494"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-70494"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-71660"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-71660"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-71660"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-70494"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-71660"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-70494"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-71660"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-71660"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-71660"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-70494"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-70494"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-70494"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-71660"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-71660"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-70494"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-71660"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10166"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10165"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10164"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10167"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/8"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00459"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-3.959611747296236"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0003805228007028316"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_2pg_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
@@ -573,16 +5625,39 @@
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pep_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b2779"/>
+        </fbc:geneProductAssociation>
       </reaction>
       <reaction id="R_EthEx" name="R_EthEx" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
         <listOfReactants>
           <speciesReference species="M_etoh_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="M_etoh_ex" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_etoh_e" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction id="R_F6PA" name="R_F6PA" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_F6PA" sboTerm="SBO:0000176" id="R_F6PA" name="Fructose 6-phosphate aldolase" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_F6PA">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/F6PA"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN0-313"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.1.2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR99075"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28002"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28003"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28004"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28005"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-15.897513754354634"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.02436004613709355"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_dha_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_g3p_c" stoichiometry="1" constant="true"/>
@@ -590,8 +5665,36 @@
         <listOfProducts>
           <speciesReference species="M_f6p_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b0825"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b3946"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction id="R_FBA" name="R_FBA" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_FBA" sboTerm="SBO:0000176" id="R_FBA" name="Fructose-bisphosphate aldolase" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_FBA">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/FBA"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.1.2.13"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01068"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR99459"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14729"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14732"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14731"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14730"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/1338"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00786"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/24.85113687488993"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0016176049400735536"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_fdp_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
@@ -599,8 +5702,35 @@
           <speciesReference species="M_dhap_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_g3p_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b2097"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b1773"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2925"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction id="R_FBP" name="R_FBP" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_FBP" sboTerm="SBO:0000176" id="R_FBP" name="Fructose-bisphosphatase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_FBP">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/FBP"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.1.3.11"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR99465"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11067"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11065"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11066"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11064"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/2084"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-6.426917551714887"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.026499241127634125"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_fdp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
@@ -609,8 +5739,35 @@
           <speciesReference species="M_f6p_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b3925"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b4232"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2930"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction id="R_FHL" name="R_FHL" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_FHL" sboTerm="SBO:0000176" id="R_FHL" name="Formate-hydrogen lyase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_FHL">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/FHL"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:FHLMULTI-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR99594"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27611"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27610"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27613"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27612"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08518"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/24.22825329417129"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.0009474335395007466"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_for_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
@@ -619,16 +5776,61 @@
           <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b4079"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2481"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2482"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2483"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2484"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2485"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2486"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2487"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2488"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2489"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2490"/>
+            </fbc:and>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b4079"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2719"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2720"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2721"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2722"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2723"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2724"/>
+            </fbc:and>
+          </fbc:or>
+        </fbc:geneProductAssociation>
       </reaction>
       <reaction id="R_FormEx" name="R_FormEx" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
         <listOfReactants>
           <speciesReference species="M_for_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="M_for_ex" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_for_e" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction id="R_FRD2" name="R_FRD2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_FRD2" sboTerm="SBO:0000176" id="R_FRD2" name="Fumarate reductase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_FRD2">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/FRD2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR99637"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29216"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29215"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29218"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29217"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08527"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-34.336634102865446"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-1.143927906984522"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_fum_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_mql8_c" stoichiometry="1" constant="true"/>
@@ -637,17 +5839,113 @@
           <speciesReference species="M_mqn8_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_succ_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:and>
+            <fbc:geneProductRef fbc:geneProduct="G_b4151"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b4152"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b4153"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b4154"/>
+          </fbc:and>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction id="R_FUM" name="R_FUM" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_FUM" sboTerm="SBO:0000176" id="R_FUM" name="Fumarase" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_FUM">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/FUM"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:FUMHYDR-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.2.1.2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01082"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR99705"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-451033"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-70982"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-70982"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-451033"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-70982"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-451033"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-451033"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-70982"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-70982"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-70982"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-451033"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-451033"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-451033"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-451033"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-451033"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-70982"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-70982"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-451033"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-70982"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-70982"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-451033"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-373141"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-451033"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-451033"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-70982"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-373145"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-70982"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-451033"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-451033"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-70982"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-451033"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-70982"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-70982"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-70982"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-451033"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-70982"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12463"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12461"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12462"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12460"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/256"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00799"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-3.4278723414240346"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/2.432071022525663e-06"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_fum_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="M_mal_DASH_L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_mal__L_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b1612"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b4122"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b1611"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction id="R_G3PD2" name="R_G3PD2" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_G3PD2" sboTerm="SBO:0000176" id="R_G3PD2" name="Glycerol-3-phosphate dehydrogenase (NADP)" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_G3PD2">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/G3PD2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.94"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00844"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR99877"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11096"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11099"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11098"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11097"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/1184"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00612"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/22.374542921730153"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.00036751500156961825"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_glyc3p_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
@@ -657,8 +5955,30 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3608"/>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction id="R_G3PD5" name="R_G3PD5" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_G3PD5" sboTerm="SBO:0000176" id="R_G3PD5" name="Glycerol-3-phosphate dehydrogenase (ubiquinone-8)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_G3PD5">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/G3PD5"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR99880"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28753"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28752"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28754"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28751"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08556"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-109.0959685019904"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.13615997110502498"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_glyc3p_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_q8_c" stoichiometry="1" constant="true"/>
@@ -667,8 +5987,43 @@
           <speciesReference species="M_dhap_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_q8h2_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b2241"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2242"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2243"/>
+            </fbc:and>
+            <fbc:geneProductRef fbc:geneProduct="G_b3426"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction id="R_G6PDH2r" name="R_G6PDH2r" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_G6PDH2r" sboTerm="SBO:0000176" id="R_G6PDH2r" name="Glucose 6-phosphate dehydrogenase" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_G6PDH2r">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/G6PDH2r"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:GLU6PDEHYDROG-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.363"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.49"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00835"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR99907"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15842"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15843"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15841"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15844"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/1176"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/6509"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00604"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-7.016607302366538"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0014247970315401925"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_g6p_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
@@ -678,8 +6033,73 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b1852"/>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction id="R_GAPD" name="R_GAPD" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_GAPD" sboTerm="SBO:0000176" id="R_GAPD" name="Glyceraldehyde-3-phosphate dehydrogenase" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_GAPD">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/GAPD"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:GAPOXNPHOSPHN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.2.1.12"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.2.1.59"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01061"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100040"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-70482"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-70449"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-70482"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-70449"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-70449"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-70449"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-70482"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-70449"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-70482"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-70449"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-70482"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-352956"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-70449"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-70449"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-70482"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-70449"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-70482"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-70449"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-352921"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-70449"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-70482"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-70482"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-70482"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-70482"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-70482"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-70449"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-70449"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-70482"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-70482"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-70449"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-70482"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-70449"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-70482"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-70449"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-70449"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-70482"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-70449"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-70482"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10303"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10300"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10302"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10301"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/7844"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00781"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/0.2816464914124026"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0003039626920273708"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_g3p_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
@@ -690,36 +6110,133 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b1779"/>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction id="R_GLCptspp" name="R_GLCptspp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_GLCptspp" sboTerm="SBO:0000185" id="R_GLCptspp" name="D-glucose transport via PEP:Pyr PTS (periplasm)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_GLCptspp">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/GLCptspp"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100237"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08612"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn05226"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-45.08377546078669"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.6035605263342846"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
-          <speciesReference species="M_glc_DASH_D_p" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_glc__D_p" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pep_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_g6p_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b2417"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b1621"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2415"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2416"/>
+            </fbc:and>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b2417"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b1101"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2415"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2416"/>
+            </fbc:and>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b1817"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b1818"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b1819"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2415"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2416"/>
+            </fbc:and>
+          </fbc:or>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction id="R_GLCt2pp" name="R_GLCt2pp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_GLCt2pp" sboTerm="SBO:0000185" id="R_GLCt2pp" name="D-glucose transport in via proton symport (periplasm)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_GLCt2pp">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/GLCt2pp"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN0-7077"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100238"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08616"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn05573"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-17.32573901764095"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
-          <speciesReference species="M_glc_DASH_D_p" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_glc__D_p" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_p" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="M_glc_DASH_D_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_glc__D_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b2943"/>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction id="R_GlcUp" name="R_GlcUp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="R_GlcUp_upper_bound">
+      <reaction metaid="meta_R_GlcUp" id="R_GlcUp" name="R_GlcUp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="R_GlcUp_upper_bound">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_GlcUp">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/0.0"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
-          <speciesReference species="M_glc_DASH_D_ex" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_glc__D_e" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="M_glc_DASH_D_p" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_glc__D_p" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction id="R_GLYCDx" name="R_GLYCDx" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_GLYCDx" sboTerm="SBO:0000176" id="R_GLYCDx" name="Glycerol dehydrogenase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_GLYCDx">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/GLYCDx"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:GLYCDEH-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.6"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01034"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100326"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13770"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13772"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13769"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13771"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/1322"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00762"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/21.055001269658078"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0011848386603530159"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_glyc_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
@@ -729,6 +6246,9 @@
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3945"/>
+        </fbc:geneProductAssociation>
       </reaction>
       <reaction metaid="meta_R_GlycUp" id="R_GlycUp" name="R_GlycUp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="R_GlycUp_upper_bound">
         <annotation>
@@ -743,13 +6263,53 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="M_glyc_ex" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_glyc_e" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_glyc_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction id="R_GLYK" name="R_GLYK" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_GLYK" sboTerm="SBO:0000176" id="R_GLYK" name="Glycerol kinase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_GLYK">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/GLYK"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:GLYCEROL-KIN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.1.30"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00847"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100348"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-75887"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-75887"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-75887"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-75887"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-75887"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-75887"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-75887"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-75887"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-75887"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-75887"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-75887"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-75887"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-75887"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-75887"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-75887"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-75887"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-75887"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21644"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21645"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21647"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21646"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/99"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00615"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-15.616718426869284"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.004846313043210435"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_glyc_c" stoichiometry="1" constant="true"/>
@@ -759,18 +6319,84 @@
           <speciesReference species="M_glyc3p_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3926"/>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction id="R_GLYOX3" name="R_GLYOX3" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_GLYOX3" sboTerm="SBO:0000176" id="R_GLYOX3" name="Glyoxalase III" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_GLYOX3">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/GLYOX3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:GLYOXIII-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.2.1.130"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R09796"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100354"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27757"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27755"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27756"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27754"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08659"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-57.48594817381604"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.10044113380115641"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_mthgxl_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_lac_DASH_D_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_lac__D_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction id="R_GND" name="R_GND" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_GND" sboTerm="SBO:0000176" id="R_GND" name="Phosphogluconate dehydrogenase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_GND">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/GND"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN-9952"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.44"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.351"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01528"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100389"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-71299"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-71299"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-71299"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-71299"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-71299"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-71299"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-71299"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-71299"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-71299"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-71299"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-71299"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-71299"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-71299"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-71299"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-71299"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-71299"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-71299"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10116"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10117"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10118"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/10119"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/108"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01115"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/10.191509793138835"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.006750403317045837"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_6pgc_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
@@ -778,15 +6404,30 @@
         <listOfProducts>
           <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_ru5p_DASH_D_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ru5p__D_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b2029"/>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction id="R_h_pEx" name="R_h_pEx" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_h_pEx" id="R_h_pEx" name="R_h_pEx" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_h_pEx">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/14.47275"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h_p" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="M_h_ex" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_e" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
       <reaction id="R_h2Ex" name="R_h2Ex" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
@@ -794,7 +6435,7 @@
           <speciesReference species="M_h2_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="M_h2_ex" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2_e" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
       <reaction id="R_h2oEx" name="R_h2oEx" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
@@ -802,21 +6443,72 @@
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="M_h2o_ex" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_e" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction id="R_HEX1" name="R_HEX1" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_HEX1" sboTerm="SBO:0000176" id="R_HEX1" name="Hexokinase (D-glucose:ATP)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_HEX1">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/HEX1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:GLUCOKIN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.1.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.1.2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00299"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100612"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17827"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17828"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17826"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17825"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/9175"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/793"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/6915"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00216"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-19.34086246537862"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.000476839003557995"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_glc_DASH_D_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_glc__D_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_g6p_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b2388"/>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction id="R_ICDHyr" name="R_ICDHyr" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_ICDHyr" sboTerm="SBO:0000176" id="R_ICDHyr" name="Isocitrate dehydrogenase (NADP)" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ICDHyr">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ICDHyr"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.42"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00267"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100781"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/19629"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/19630"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/19631"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/19632"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/269"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00198"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/5.091884812294893"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0056356997190265545"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_icit_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
@@ -826,8 +6518,33 @@
           <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b1136"/>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction id="R_ICL" name="R_ICL" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_ICL" sboTerm="SBO:0000176" id="R_ICL" name="Isocitrate lyase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ICL">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ICL"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.1.3.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00479"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100789"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13248"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13245"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13246"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13247"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/911"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00336"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/9.515264105294023"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-6.961473298013157e-05"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_icit_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
@@ -835,29 +6552,83 @@
           <speciesReference species="M_glx_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_succ_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b4015"/>
+        </fbc:geneProductAssociation>
       </reaction>
       <reaction id="R_LacEx" name="R_LacEx" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
         <listOfReactants>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_lac_DASH_D_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_lac__D_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_h_p" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_lac_ex" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_lac_e" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction id="R_LDH_D" name="R_LDH_D" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_LDH_D" sboTerm="SBO:0000176" id="R_LDH_D" name="D-lactate dehydrogenase" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_LDH_D">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/LDH_D"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:DLACTDEHYDROGNAD-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.28"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00704"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101037"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16370"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16371"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16372"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16369"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/155"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00500"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-20.48231613030316"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/8.659739592076221e-15"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="M_lac_DASH_D_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_lac__D_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b2133"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b1380"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction id="R_MALS" name="R_MALS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_MALS" sboTerm="SBO:0000176" id="R_MALS" name="Malate synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_MALS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/MALS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:MALSYN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.3.9"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00472"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101347"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18181"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18182"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18184"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18183"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00330"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-38.004881916520816"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.00359250140508849"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_accoa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_glx_c" stoichiometry="1" constant="true"/>
@@ -866,12 +6637,90 @@
         <listOfProducts>
           <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_mal_DASH_L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_mal__L_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b4014"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2976"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction id="R_MDH" name="R_MDH" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_MDH" sboTerm="SBO:0000176" id="R_MDH" name="Malate dehydrogenase" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_MDH">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/MDH"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:MALATE-DEH-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.37"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.299"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00342"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101439"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-70979"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-198508"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-70979"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-70979"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-71783"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-71783"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-198508"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-71783"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-198508"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-70979"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-198508"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-71783"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-71783"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-71783"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-198508"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-70979"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-71783"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-198508"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-372422"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-71783"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-70979"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-198508"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-70979"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-71783"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-71783"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-198508"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-70979"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-70979"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-198508"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-71783"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-70979"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-71783"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-198508"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-372855"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-70979"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-70979"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-373047"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-198508"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-71783"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-70979"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-70979"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-71783"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-198508"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-198508"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-71783"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-70979"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-71783"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-70979"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21432"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21433"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21434"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21435"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/113"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00248"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/26.563754485540258"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.00011604275815814587"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
-          <speciesReference species="M_mal_DASH_L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_mal__L_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
@@ -879,10 +6728,37 @@
           <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_oaa_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3236"/>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction id="R_ME1" name="R_ME1" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_ME1" sboTerm="SBO:0000176" id="R_ME1" name="Malic enzyme (NAD)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ME1">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ME1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:1.1.1.39-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.38"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.39"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00214"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101446"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12655"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12654"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12653"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12656"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/141"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00159"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/11.944277060145822"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0040888374851758644"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
-          <speciesReference species="M_mal_DASH_L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_mal__L_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
@@ -890,10 +6766,36 @@
           <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b1479"/>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction id="R_ME2" name="R_ME2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_ME2" sboTerm="SBO:0000176" id="R_ME2" name="Malic enzyme (NADP)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_ME2">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ME2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:MALIC-NADP-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.40"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00216"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101443"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18255"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18256"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18254"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18253"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/142"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00161"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/11.485177525552416"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0031491851918278384"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
-          <speciesReference species="M_mal_DASH_L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_mal__L_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
@@ -901,8 +6803,34 @@
           <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b2463"/>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction id="R_MGSA" name="R_MGSA" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_MGSA" sboTerm="SBO:0000176" id="R_MGSA" name="Methylglyoxal synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_MGSA">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/MGSA"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:METHGLYSYN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.2.3.3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01016"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101551"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17939"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17938"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17937"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17940"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/176"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00748"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-60.2496012542968"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.09544742984097275"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_dhap_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
@@ -910,8 +6838,27 @@
           <speciesReference species="M_mthgxl_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0963"/>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction id="R_NADH16pp" name="R_NADH16pp" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_NADH16pp" sboTerm="SBO:0000185" id="R_NADH16pp" name="NADH dehydrogenase (ubiquinone-8 &amp; 3 protons) (periplasm)" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_NADH16pp">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/NADH16pp"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.6.5.3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101864"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08972"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-79.95394219095436"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/6.211579665462097"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h_c" stoichiometry="4" constant="true"/>
           <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
@@ -922,8 +6869,41 @@
           <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_q8h2_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:and>
+            <fbc:geneProductRef fbc:geneProduct="G_b2276"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2277"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2278"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2279"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2280"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2281"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2282"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2283"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2284"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2285"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2286"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2287"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2288"/>
+          </fbc:and>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction id="R_NADH17pp" name="R_NADH17pp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_NADH17pp" sboTerm="SBO:0000185" id="R_NADH17pp" name="NADH dehydrogenase (menaquinone-8 &amp; 3 protons) (periplasm)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_NADH17pp">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/NADH17pp"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.6.5.3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101865"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn08973"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/27.946891798261504"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/4.874554708979394"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h_c" stoichiometry="4" constant="true"/>
           <speciesReference species="M_mqn8_c" stoichiometry="1" constant="true"/>
@@ -934,8 +6914,49 @@
           <speciesReference species="M_mql8_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:and>
+            <fbc:geneProductRef fbc:geneProduct="G_b2276"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2277"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2278"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2279"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2280"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2281"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2282"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2283"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2284"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2285"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2286"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2287"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2288"/>
+          </fbc:and>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction id="R_NADTRHD" name="R_NADTRHD" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_NADTRHD" sboTerm="SBO:0000176" id="R_NADTRHD" name="NAD transhydrogenase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_NADTRHD">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/NADTRHD"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:PYRNUTRANSHYDROGEN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.6.1.3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.6.1.2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.6.1.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00112"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101898"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11692"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11695"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11694"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11693"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00083"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/0.45909953459317876"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0009396522933482476"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
@@ -944,16 +6965,70 @@
           <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b3962"/>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b1602"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b1603"/>
+            </fbc:and>
+          </fbc:or>
+        </fbc:geneProductAssociation>
       </reaction>
       <reaction id="R_O2Up" name="R_O2Up" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
         <listOfReactants>
-          <speciesReference species="M_o2_ex" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_o2_e" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_o2_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction id="R_PDH" name="R_PDH" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_PDH" sboTerm="SBO:0000176" id="R_PDH" name="Pyruvate dehydrogenase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PDH">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PDH"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:PYRUVDEH-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.2.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.8.1.4"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.2.1.51"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.2.4.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.1.12"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00209"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102425"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-71397"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-71397"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-373177"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-71397"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-71397"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-71397"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-71397"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-71397"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-71397"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-71397"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-71397"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-71397"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-71397"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-71397"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-71397"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-71397"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-71397"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-71397"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28043"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28045"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28044"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28042"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/523"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00154"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-34.36700334845227"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.008535499964858806"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
@@ -964,8 +7039,34 @@
           <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:and>
+            <fbc:geneProductRef fbc:geneProduct="G_b0114"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0115"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0116"/>
+          </fbc:and>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction id="R_PFK" name="R_PFK" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_PFK" sboTerm="SBO:0000176" id="R_PFK" name="Phosphofructokinase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PFK">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PFK"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.1.11"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102507"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16111"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16109"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16110"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16112"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-22.79170036073799"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.026976052871656147"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_f6p_c" stoichiometry="1" constant="true"/>
@@ -975,8 +7076,37 @@
           <speciesReference species="M_fdp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b3916"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b1723"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction id="R_PFL" name="R_PFL" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_PFL" sboTerm="SBO:0000176" id="R_PFL" name="Pyruvate formate lyase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PFL">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PFL"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:PYRUVFORMLY-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.1.54"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00212"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102514"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11847"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11845"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11844"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11846"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/146"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00157"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-20.141012982005364"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0004378901385389194"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
@@ -985,16 +7115,117 @@
           <speciesReference species="M_accoa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_for_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b0902"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b0903"/>
+            </fbc:and>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b0902"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b3114"/>
+            </fbc:and>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b3951"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b3952"/>
+            </fbc:and>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="G_b0902"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b0903"/>
+              <fbc:geneProductRef fbc:geneProduct="G_b2579"/>
+            </fbc:and>
+          </fbc:or>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction id="R_PGI" name="R_PGI" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_PGI" sboTerm="SBO:0000176" id="R_PGI" name="Glucose-6-phosphate isomerase" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PGI">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PGI"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:PGLUCISOM-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/5.3.1.9"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102535"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/7.105583387739557"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.025878202444730162"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_g6p_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_f6p_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b4025"/>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction id="R_PGK" name="R_PGK" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_PGK" sboTerm="SBO:0000176" id="R_PGK" name="Phosphoglycerate kinase" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PGK">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PGK"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:PHOSGLYPHOS-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.2.3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01512"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102538"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-71850"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-71850"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-71850"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-71850"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-71850"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-353039"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-353023"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-71850"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-70486"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-71850"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-70486"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-71850"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-70486"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-70486"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-70486"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-70486"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-70486"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-70486"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-70486"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-70486"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-71850"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-70486"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-70486"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-70486"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-71850"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-71850"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-71850"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-71850"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-70486"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-70486"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-71850"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-71850"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-70486"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-70486"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-71850"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-71850"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-70486"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-71850"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14801"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14804"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14802"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/14803"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/7644"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01100"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-19.22772852043056"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.00040020806346412457"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_13dpg_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
@@ -1003,8 +7234,50 @@
           <speciesReference species="M_3pg_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b2926"/>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction id="R_PGL" name="R_PGL" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_PGL" sboTerm="SBO:0000176" id="R_PGL" name="6-phosphogluconolactonase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PGL">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PGL"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:6PGLUCONOLACT-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.1.1.31"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R02035"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102539"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-71296"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-71296"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-71296"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-71296"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-71296"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-71296"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-71296"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-71296"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-71296"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-71296"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-71296"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-71296"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-71296"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-71296"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-71296"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-71296"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12559"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12556"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12557"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/12558"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/109"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01476"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-25.544117128900496"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0010325587184541127"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_6pgl_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
@@ -1013,16 +7286,107 @@
           <speciesReference species="M_6pgc_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0767"/>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction id="R_PGM" name="R_PGM" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_PGM" sboTerm="SBO:0000176" id="R_PGM" name="Phosphoglycerate mutase" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PGM">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PGM"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:3PGAREARR-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RXN-15513"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/5.4.2.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/5.4.2.11"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/5.4.2.12"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01518"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102547"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-71654"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-71654"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-71445"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-71445"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-71445"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-71654"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-71445"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-71445"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-71654"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-71654"/>
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+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-71445"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-71445"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-352994"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-71654"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-71445"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-71445"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-71654"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-71654"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-71654"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-353014"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-71654"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-71654"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-71654"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-71654"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-71445"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-71654"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-71445"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-71445"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-71654"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-71654"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-71445"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-71445"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-71445"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-71654"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15902"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15903"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15901"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15904"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/7641"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01106"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/4.126089679779312"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0005462791117255479"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_3pg_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_2pg_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b3612"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b4395"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0755"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction id="R_POX" name="R_POX" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_POX" sboTerm="SBO:0000176" id="R_POX" name="Pyruvate oxidase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_POX">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/POX"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR103067"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29168"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29170"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29167"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29169"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09167"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-200.6014159820337"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.12758065768690763"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
@@ -1033,8 +7397,33 @@
           <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_q8h2_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b0871"/>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction id="R_PPC" name="R_PPC" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_PPC" sboTerm="SBO:0000176" id="R_PPC" name="Phosphoenolpyruvate carboxylase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PPC">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PPC"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.1.1.31"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00345"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR103096"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23073"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23072"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23075"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/23074"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/150"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00251"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-40.341537387279125"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.0028106488039349653"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
@@ -1045,8 +7434,34 @@
           <speciesReference species="M_oaa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3956"/>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction id="R_PPCK" name="R_PPCK" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_PPCK" sboTerm="SBO:0000176" id="R_PPCK" name="Phosphoenolpyruvate carboxykinase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PPCK">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PPCK"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:PEPCARBOXYKIN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.1.1.49"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00341"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR103099"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18620"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18618"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18617"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18619"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/151"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00247"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/11.122919474826347"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.003287460547956987"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_oaa_c" stoichiometry="1" constant="true"/>
@@ -1056,8 +7471,34 @@
           <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pep_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3403"/>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction id="R_PPS" name="R_PPS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_PPS" sboTerm="SBO:0000176" id="R_PPS" name="Phosphoenolpyruvate synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PPS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PPS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:PEPSYNTH-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.9.2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00199"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR103140"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11364"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11367"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11366"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/11365"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/148"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00147"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-3.6213062409316876"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.00026671463697478665"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
@@ -1069,8 +7510,34 @@
           <speciesReference species="M_pep_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b1702"/>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction id="R_PTAr" name="R_PTAr" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_PTAr" sboTerm="SBO:0000176" id="R_PTAr" name="Phosphotransacetylase" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PTAr">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PTAr"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:PHOSACETYLTRANS-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.1.8"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00230"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR103319"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/19521"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/19523"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/19522"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/19524"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/72"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00173"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/9.999151332148358"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/4.293076378458771e-05"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_accoa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
@@ -1079,8 +7546,56 @@
           <speciesReference species="M_actp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b2297"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2458"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction id="R_PYK" name="R_PYK" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_PYK" sboTerm="SBO:0000176" id="R_PYK" name="Pyruvate kinase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_PYK">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PYK"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:PEPDEPHOS-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.7.1.40"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00200"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR103371"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-71670"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-353056"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-71670"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-71670"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-71670"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-71670"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-71670"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-71670"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-71670"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-71670"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-71670"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-71670"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-71670"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-71670"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-71670"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-71670"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-71670"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-71670"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-71670"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18160"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18159"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18158"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18157"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/9"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00148"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-25.742396900220598"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.000685334179060631"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
@@ -1090,32 +7605,157 @@
           <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b1854"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b1676"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction id="R_RPE" name="R_RPE" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_RPE" sboTerm="SBO:0000176" id="R_RPE" name="Ribulose 5-phosphate 3-epimerase" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_RPE">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/RPE"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:RIBULP3EPIM-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/5.1.3.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01529"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104083"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-71303"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-199803"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-71303"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-71303"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-71303"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-199803"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-199803"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-199803"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-199803"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-71303"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-199803"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-71303"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-71303"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-71303"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-71303"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-199803"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-71303"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-199803"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-199803"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-71303"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-71303"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-71303"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-199803"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-71303"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-199803"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-199803"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-199803"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-71303"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-71303"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-199803"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-71303"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-199803"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-71303"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-199803"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-199803"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-199803"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13677"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13680"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13678"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13679"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/62"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn01116"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-3.3940191646475455"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0008101477973079954"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
-          <speciesReference species="M_ru5p_DASH_D_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ru5p__D_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="M_xu5p_DASH_D_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_xu5p__D_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b4301"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b3386"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction id="R_RPI" name="R_RPI" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_RPI" sboTerm="SBO:0000176" id="R_RPI" name="Ribose-5-phosphate isomerase" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_RPI">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/RPI"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/5.3.1.6"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104084"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/4.456392675056634"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.10296351955814127"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_r5p_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="M_ru5p_DASH_D_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ru5p__D_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b2914"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b4090"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction id="R_SuccEx" name="R_SuccEx" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_SuccEx" id="R_SuccEx" name="R_SuccEx" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_SuccEx">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-28.9455"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_succ_p" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="M_succ_ex" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_succ_e" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction id="R_SUCCt2_2pp" name="R_SUCCt2_2pp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_SUCCt2_2pp" sboTerm="SBO:0000185" id="R_SUCCt2_2pp" name="Succinate transport via proton symport (2 H) (periplasm)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_SUCCt2_2pp">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/SUCCt2_2pp"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:TRANS-RXN-121"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104620"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29305"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29306"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29304"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29303"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn10154"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09269"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-5.683349509194247"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h_p" stoichiometry="2" constant="true"/>
           <speciesReference species="M_succ_p" stoichiometry="1" constant="true"/>
@@ -1124,8 +7764,26 @@
           <speciesReference species="M_h_c" stoichiometry="2" constant="true"/>
           <speciesReference species="M_succ_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3528"/>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction id="R_SUCCt3pp" name="R_SUCCt3pp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_SUCCt3pp" sboTerm="SBO:0000185" id="R_SUCCt3pp" name="Succinate transport out via proton antiport (periplasm)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_SUCCt3pp">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/SUCCt3pp"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104623"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09270"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-46.292319258166266"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h_p" stoichiometry="1" constant="true"/>
           <speciesReference species="M_succ_c" stoichiometry="1" constant="true"/>
@@ -1142,19 +7800,40 @@
               <bqbiol:is>
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/cnapy-default/(0.0, 0.0)"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/28.9455"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.0"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="M_succ_ex" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_succ_e" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_succ_p" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction id="R_SUCDi" name="R_SUCDi" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_SUCDi" sboTerm="SBO:0000176" id="R_SUCDi" name="Succinate dehydrogenase (irreversible)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_SUCDi">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/SUCDi"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR99641"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29190"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29189"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29187"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/29188"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09272"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-73.56419988635031"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.13132380242200892"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_q8_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_succ_c" stoichiometry="1" constant="true"/>
@@ -1163,8 +7842,57 @@
           <speciesReference species="M_fum_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_q8h2_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:and>
+            <fbc:geneProductRef fbc:geneProduct="G_b0721"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0722"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0723"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0724"/>
+          </fbc:and>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction id="R_SUCOAS" name="R_SUCOAS" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_SUCOAS" sboTerm="SBO:0000176" id="R_SUCOAS" name="Succinyl-CoA synthetase (ADP-forming)" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_SUCOAS">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/SUCOAS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:SUCCCOASYN-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/6.2.1.5"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00405"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104635"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-70997"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-372977"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-70997"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-373134"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-TGU-70997"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-70997"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-70997"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-70997"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-70997"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-70997"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-70997"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-70997"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-70997"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-70997"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-70997"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-70997"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-70997"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-70997"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17664"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17663"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17662"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17661"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/260"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00285"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/2.5185823568734804"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.000261879848073687"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
@@ -1175,8 +7903,35 @@
           <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_succ_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:and>
+            <fbc:geneProductRef fbc:geneProduct="G_b0728"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0729"/>
+          </fbc:and>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction id="R_TALA" name="R_TALA" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_TALA" sboTerm="SBO:0000176" id="R_TALA" name="Transaldolase" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_TALA">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/TALA"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:TRANSALDOL-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.2.1.2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01827"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104715"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17056"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17055"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17054"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/17053"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/3.419779975122651"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.025319283339884334"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_g3p_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_s7p_c" stoichiometry="1" constant="true"/>
@@ -1185,8 +7940,31 @@
           <speciesReference species="M_e4p_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_f6p_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b2464"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b0008"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction id="R_THD2pp" name="R_THD2pp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_THD2pp" sboTerm="SBO:0000185" id="R_THD2pp" name="NAD(P) transhydrogenase (periplasm)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_THD2pp">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/THD2pp"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.6.1.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104805"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn10125"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn09295"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-35.10954537950019"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.33576292404529656"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_h_p" stoichiometry="2" constant="true"/>
           <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
@@ -1197,34 +7975,150 @@
           <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:and>
+            <fbc:geneProductRef fbc:geneProduct="G_b1602"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b1603"/>
+          </fbc:and>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction id="R_TKT1" name="R_TKT1" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_TKT1" sboTerm="SBO:0000176" id="R_TKT1" name="Transketolase" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_TKT1">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/TKT1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.2.1.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104868"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-1.4928869154086897"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.10129091190800386"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_r5p_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_xu5p_DASH_D_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_xu5p__D_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_g3p_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_s7p_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b2935"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2465"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction id="R_TKT2" name="R_TKT2" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_TKT2" sboTerm="SBO:0000176" id="R_TKT2" name="Transketolase" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_TKT2">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/TKT2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:2TRANSKETO-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.2.1.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01830"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104869"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27627"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27628"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27626"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/27629"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/-5.926767169219403"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/-0.02481294096656982"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_e4p_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_xu5p_DASH_D_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_xu5p__D_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_f6p_c" stoichiometry="1" constant="true"/>
           <speciesReference species="M_g3p_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_b2935"/>
+            <fbc:geneProductRef fbc:geneProduct="G_b2465"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
       </reaction>
-      <reaction id="R_TPI" name="R_TPI" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+      <reaction metaid="meta_R_TPI" sboTerm="SBO:0000176" id="R_TPI" name="Triose-phosphate isomerase" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_TPI">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/TPI"/>
+                  <rdf:li rdf:resource="https://identifiers.org/biocyc/META:TRIOSEPISOMERIZATION-RXN"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/5.3.1.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01015"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104918"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-70481"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-70481"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-70481"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-70481"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-352927"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-70454"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-70481"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-70454"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-XTR-70454"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-70481"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-BTA-70454"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-352914"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-70481"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-70454"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-70454"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-70481"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-70454"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-70481"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-OSA-70481"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DRE-70481"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-ATH-70454"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-HSA-70454"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SSC-70454"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-70454"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SCE-70481"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CFA-70481"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-PFA-70481"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DDI-70481"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-70454"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-SPO-70481"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-RNO-70454"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-MMU-70454"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-CEL-70454"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-70481"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-GGA-70454"/>
+                  <rdf:li rdf:resource="https://identifiers.org/reactome.reaction/R-DME-70454"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18587"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18588"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18586"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18585"/>
+                  <rdf:li rdf:resource="https://identifiers.org/sabiork/4"/>
+                  <rdf:li rdf:resource="https://identifiers.org/seed.reaction/rxn00747"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0/5.70600352385182"/>
+                  <rdf:li rdf:resource="https://identifiers.org/dG0_uncertainty/0.00172377362515049"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="M_dhap_c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="M_g3p_c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="G_b3919"/>
+        </fbc:geneProductAssociation>
       </reaction>
     </listOfReactions>
     <fbc:listOfObjectives fbc:activeObjective="obj">
@@ -1234,5 +8128,155 @@
         </fbc:listOfFluxObjectives>
       </fbc:objective>
     </fbc:listOfObjectives>
+    <fbc:listOfGeneProducts>
+      <fbc:geneProduct fbc:id="G_b1241" fbc:name="G_b1241" fbc:label="G_b1241"/>
+      <fbc:geneProduct fbc:id="G_b0351" fbc:name="G_b0351" fbc:label="G_b0351"/>
+      <fbc:geneProduct fbc:id="G_b2296" fbc:name="G_b2296" fbc:label="G_b2296"/>
+      <fbc:geneProduct fbc:id="G_b3115" fbc:name="G_b3115" fbc:label="G_b3115"/>
+      <fbc:geneProduct fbc:id="G_b1849" fbc:name="G_b1849" fbc:label="G_b1849"/>
+      <fbc:geneProduct fbc:id="G_b0118" fbc:name="G_b0118" fbc:label="G_b0118"/>
+      <fbc:geneProduct fbc:id="G_b1276" fbc:name="G_b1276" fbc:label="G_b1276"/>
+      <fbc:geneProduct fbc:id="G_b0474" fbc:name="G_b0474" fbc:label="G_b0474"/>
+      <fbc:geneProduct fbc:id="G_b0726" fbc:name="G_b0726" fbc:label="G_b0726"/>
+      <fbc:geneProduct fbc:id="G_b0727" fbc:name="G_b0727" fbc:label="G_b0727"/>
+      <fbc:geneProduct fbc:id="G_b0116" fbc:name="G_b0116" fbc:label="G_b0116"/>
+      <fbc:geneProduct fbc:id="G_b0356" fbc:name="G_b0356" fbc:label="G_b0356"/>
+      <fbc:geneProduct fbc:id="G_b1478" fbc:name="G_b1478" fbc:label="G_b1478"/>
+      <fbc:geneProduct fbc:id="G_b3733" fbc:name="G_b3733" fbc:label="G_b3733"/>
+      <fbc:geneProduct fbc:id="G_b3735" fbc:name="G_b3735" fbc:label="G_b3735"/>
+      <fbc:geneProduct fbc:id="G_b3739" fbc:name="G_b3739" fbc:label="G_b3739"/>
+      <fbc:geneProduct fbc:id="G_b3734" fbc:name="G_b3734" fbc:label="G_b3734"/>
+      <fbc:geneProduct fbc:id="G_b3736" fbc:name="G_b3736" fbc:label="G_b3736"/>
+      <fbc:geneProduct fbc:id="G_b3737" fbc:name="G_b3737" fbc:label="G_b3737"/>
+      <fbc:geneProduct fbc:id="G_b3738" fbc:name="G_b3738" fbc:label="G_b3738"/>
+      <fbc:geneProduct fbc:id="G_b3731" fbc:name="G_b3731" fbc:label="G_b3731"/>
+      <fbc:geneProduct fbc:id="G_b3732" fbc:name="G_b3732" fbc:label="G_b3732"/>
+      <fbc:geneProduct fbc:id="G_b0720" fbc:name="G_b0720" fbc:label="G_b0720"/>
+      <fbc:geneProduct fbc:id="G_b0429" fbc:name="G_b0429" fbc:label="G_b0429"/>
+      <fbc:geneProduct fbc:id="G_b0430" fbc:name="G_b0430" fbc:label="G_b0430"/>
+      <fbc:geneProduct fbc:id="G_b0431" fbc:name="G_b0431" fbc:label="G_b0431"/>
+      <fbc:geneProduct fbc:id="G_b0432" fbc:name="G_b0432" fbc:label="G_b0432"/>
+      <fbc:geneProduct fbc:id="G_b1850" fbc:name="G_b1850" fbc:label="G_b1850"/>
+      <fbc:geneProduct fbc:id="G_b1851" fbc:name="G_b1851" fbc:label="G_b1851"/>
+      <fbc:geneProduct fbc:id="G_b2779" fbc:name="G_b2779" fbc:label="G_b2779"/>
+      <fbc:geneProduct fbc:id="G_b3946" fbc:name="G_b3946" fbc:label="G_b3946"/>
+      <fbc:geneProduct fbc:id="G_b0825" fbc:name="G_b0825" fbc:label="G_b0825"/>
+      <fbc:geneProduct fbc:id="G_b2097" fbc:name="G_b2097" fbc:label="G_b2097"/>
+      <fbc:geneProduct fbc:id="G_b2925" fbc:name="G_b2925" fbc:label="G_b2925"/>
+      <fbc:geneProduct fbc:id="G_b1773" fbc:name="G_b1773" fbc:label="G_b1773"/>
+      <fbc:geneProduct fbc:id="G_b3925" fbc:name="G_b3925" fbc:label="G_b3925"/>
+      <fbc:geneProduct fbc:id="G_b4232" fbc:name="G_b4232" fbc:label="G_b4232"/>
+      <fbc:geneProduct fbc:id="G_b2930" fbc:name="G_b2930" fbc:label="G_b2930"/>
+      <fbc:geneProduct fbc:id="G_b2721" fbc:name="G_b2721" fbc:label="G_b2721"/>
+      <fbc:geneProduct fbc:id="G_b2486" fbc:name="G_b2486" fbc:label="G_b2486"/>
+      <fbc:geneProduct fbc:id="G_b2484" fbc:name="G_b2484" fbc:label="G_b2484"/>
+      <fbc:geneProduct fbc:id="G_b2489" fbc:name="G_b2489" fbc:label="G_b2489"/>
+      <fbc:geneProduct fbc:id="G_b2722" fbc:name="G_b2722" fbc:label="G_b2722"/>
+      <fbc:geneProduct fbc:id="G_b4079" fbc:name="G_b4079" fbc:label="G_b4079"/>
+      <fbc:geneProduct fbc:id="G_b2719" fbc:name="G_b2719" fbc:label="G_b2719"/>
+      <fbc:geneProduct fbc:id="G_b2481" fbc:name="G_b2481" fbc:label="G_b2481"/>
+      <fbc:geneProduct fbc:id="G_b2485" fbc:name="G_b2485" fbc:label="G_b2485"/>
+      <fbc:geneProduct fbc:id="G_b2487" fbc:name="G_b2487" fbc:label="G_b2487"/>
+      <fbc:geneProduct fbc:id="G_b2482" fbc:name="G_b2482" fbc:label="G_b2482"/>
+      <fbc:geneProduct fbc:id="G_b2490" fbc:name="G_b2490" fbc:label="G_b2490"/>
+      <fbc:geneProduct fbc:id="G_b2724" fbc:name="G_b2724" fbc:label="G_b2724"/>
+      <fbc:geneProduct fbc:id="G_b2723" fbc:name="G_b2723" fbc:label="G_b2723"/>
+      <fbc:geneProduct fbc:id="G_b2483" fbc:name="G_b2483" fbc:label="G_b2483"/>
+      <fbc:geneProduct fbc:id="G_b2720" fbc:name="G_b2720" fbc:label="G_b2720"/>
+      <fbc:geneProduct fbc:id="G_b2488" fbc:name="G_b2488" fbc:label="G_b2488"/>
+      <fbc:geneProduct fbc:id="G_b4152" fbc:name="G_b4152" fbc:label="G_b4152"/>
+      <fbc:geneProduct fbc:id="G_b4154" fbc:name="G_b4154" fbc:label="G_b4154"/>
+      <fbc:geneProduct fbc:id="G_b4151" fbc:name="G_b4151" fbc:label="G_b4151"/>
+      <fbc:geneProduct fbc:id="G_b4153" fbc:name="G_b4153" fbc:label="G_b4153"/>
+      <fbc:geneProduct fbc:id="G_b1611" fbc:name="G_b1611" fbc:label="G_b1611"/>
+      <fbc:geneProduct fbc:id="G_b4122" fbc:name="G_b4122" fbc:label="G_b4122"/>
+      <fbc:geneProduct fbc:id="G_b1612" fbc:name="G_b1612" fbc:label="G_b1612"/>
+      <fbc:geneProduct fbc:id="G_b3608" fbc:name="G_b3608" fbc:label="G_b3608"/>
+      <fbc:geneProduct fbc:id="G_b2242" fbc:name="G_b2242" fbc:label="G_b2242"/>
+      <fbc:geneProduct fbc:id="G_b2241" fbc:name="G_b2241" fbc:label="G_b2241"/>
+      <fbc:geneProduct fbc:id="G_b2243" fbc:name="G_b2243" fbc:label="G_b2243"/>
+      <fbc:geneProduct fbc:id="G_b3426" fbc:name="G_b3426" fbc:label="G_b3426"/>
+      <fbc:geneProduct fbc:id="G_b1852" fbc:name="G_b1852" fbc:label="G_b1852"/>
+      <fbc:geneProduct fbc:id="G_b1779" fbc:name="G_b1779" fbc:label="G_b1779"/>
+      <fbc:geneProduct fbc:id="G_b2415" fbc:name="G_b2415" fbc:label="G_b2415"/>
+      <fbc:geneProduct fbc:id="G_b1819" fbc:name="G_b1819" fbc:label="G_b1819"/>
+      <fbc:geneProduct fbc:id="G_b2416" fbc:name="G_b2416" fbc:label="G_b2416"/>
+      <fbc:geneProduct fbc:id="G_b2417" fbc:name="G_b2417" fbc:label="G_b2417"/>
+      <fbc:geneProduct fbc:id="G_b1621" fbc:name="G_b1621" fbc:label="G_b1621"/>
+      <fbc:geneProduct fbc:id="G_b1818" fbc:name="G_b1818" fbc:label="G_b1818"/>
+      <fbc:geneProduct fbc:id="G_b1817" fbc:name="G_b1817" fbc:label="G_b1817"/>
+      <fbc:geneProduct fbc:id="G_b1101" fbc:name="G_b1101" fbc:label="G_b1101"/>
+      <fbc:geneProduct fbc:id="G_b2943" fbc:name="G_b2943" fbc:label="G_b2943"/>
+      <fbc:geneProduct fbc:id="G_b3945" fbc:name="G_b3945" fbc:label="G_b3945"/>
+      <fbc:geneProduct fbc:id="G_b3926" fbc:name="G_b3926" fbc:label="G_b3926"/>
+      <fbc:geneProduct fbc:id="G_b2029" fbc:name="G_b2029" fbc:label="G_b2029"/>
+      <fbc:geneProduct fbc:id="G_b2388" fbc:name="G_b2388" fbc:label="G_b2388"/>
+      <fbc:geneProduct fbc:id="G_b1136" fbc:name="G_b1136" fbc:label="G_b1136"/>
+      <fbc:geneProduct fbc:id="G_b4015" fbc:name="G_b4015" fbc:label="G_b4015"/>
+      <fbc:geneProduct fbc:id="G_b2133" fbc:name="G_b2133" fbc:label="G_b2133"/>
+      <fbc:geneProduct fbc:id="G_b1380" fbc:name="G_b1380" fbc:label="G_b1380"/>
+      <fbc:geneProduct fbc:id="G_b2976" fbc:name="G_b2976" fbc:label="G_b2976"/>
+      <fbc:geneProduct fbc:id="G_b4014" fbc:name="G_b4014" fbc:label="G_b4014"/>
+      <fbc:geneProduct fbc:id="G_b3236" fbc:name="G_b3236" fbc:label="G_b3236"/>
+      <fbc:geneProduct fbc:id="G_b1479" fbc:name="G_b1479" fbc:label="G_b1479"/>
+      <fbc:geneProduct fbc:id="G_b2463" fbc:name="G_b2463" fbc:label="G_b2463"/>
+      <fbc:geneProduct fbc:id="G_b0963" fbc:name="G_b0963" fbc:label="G_b0963"/>
+      <fbc:geneProduct fbc:id="G_b2286" fbc:name="G_b2286" fbc:label="G_b2286"/>
+      <fbc:geneProduct fbc:id="G_b2288" fbc:name="G_b2288" fbc:label="G_b2288"/>
+      <fbc:geneProduct fbc:id="G_b2283" fbc:name="G_b2283" fbc:label="G_b2283"/>
+      <fbc:geneProduct fbc:id="G_b2278" fbc:name="G_b2278" fbc:label="G_b2278"/>
+      <fbc:geneProduct fbc:id="G_b2285" fbc:name="G_b2285" fbc:label="G_b2285"/>
+      <fbc:geneProduct fbc:id="G_b2279" fbc:name="G_b2279" fbc:label="G_b2279"/>
+      <fbc:geneProduct fbc:id="G_b2277" fbc:name="G_b2277" fbc:label="G_b2277"/>
+      <fbc:geneProduct fbc:id="G_b2287" fbc:name="G_b2287" fbc:label="G_b2287"/>
+      <fbc:geneProduct fbc:id="G_b2282" fbc:name="G_b2282" fbc:label="G_b2282"/>
+      <fbc:geneProduct fbc:id="G_b2284" fbc:name="G_b2284" fbc:label="G_b2284"/>
+      <fbc:geneProduct fbc:id="G_b2280" fbc:name="G_b2280" fbc:label="G_b2280"/>
+      <fbc:geneProduct fbc:id="G_b2276" fbc:name="G_b2276" fbc:label="G_b2276"/>
+      <fbc:geneProduct fbc:id="G_b2281" fbc:name="G_b2281" fbc:label="G_b2281"/>
+      <fbc:geneProduct fbc:id="G_b1602" fbc:name="G_b1602" fbc:label="G_b1602"/>
+      <fbc:geneProduct fbc:id="G_b3962" fbc:name="G_b3962" fbc:label="G_b3962"/>
+      <fbc:geneProduct fbc:id="G_b1603" fbc:name="G_b1603" fbc:label="G_b1603"/>
+      <fbc:geneProduct fbc:id="G_b0115" fbc:name="G_b0115" fbc:label="G_b0115"/>
+      <fbc:geneProduct fbc:id="G_b0114" fbc:name="G_b0114" fbc:label="G_b0114"/>
+      <fbc:geneProduct fbc:id="G_b1723" fbc:name="G_b1723" fbc:label="G_b1723"/>
+      <fbc:geneProduct fbc:id="G_b3916" fbc:name="G_b3916" fbc:label="G_b3916"/>
+      <fbc:geneProduct fbc:id="G_b2579" fbc:name="G_b2579" fbc:label="G_b2579"/>
+      <fbc:geneProduct fbc:id="G_b0903" fbc:name="G_b0903" fbc:label="G_b0903"/>
+      <fbc:geneProduct fbc:id="G_b3951" fbc:name="G_b3951" fbc:label="G_b3951"/>
+      <fbc:geneProduct fbc:id="G_b0902" fbc:name="G_b0902" fbc:label="G_b0902"/>
+      <fbc:geneProduct fbc:id="G_b3952" fbc:name="G_b3952" fbc:label="G_b3952"/>
+      <fbc:geneProduct fbc:id="G_b3114" fbc:name="G_b3114" fbc:label="G_b3114"/>
+      <fbc:geneProduct fbc:id="G_b4025" fbc:name="G_b4025" fbc:label="G_b4025"/>
+      <fbc:geneProduct fbc:id="G_b2926" fbc:name="G_b2926" fbc:label="G_b2926"/>
+      <fbc:geneProduct fbc:id="G_b0767" fbc:name="G_b0767" fbc:label="G_b0767"/>
+      <fbc:geneProduct fbc:id="G_b3612" fbc:name="G_b3612" fbc:label="G_b3612"/>
+      <fbc:geneProduct fbc:id="G_b0755" fbc:name="G_b0755" fbc:label="G_b0755"/>
+      <fbc:geneProduct fbc:id="G_b4395" fbc:name="G_b4395" fbc:label="G_b4395"/>
+      <fbc:geneProduct fbc:id="G_b0871" fbc:name="G_b0871" fbc:label="G_b0871"/>
+      <fbc:geneProduct fbc:id="G_b3956" fbc:name="G_b3956" fbc:label="G_b3956"/>
+      <fbc:geneProduct fbc:id="G_b3403" fbc:name="G_b3403" fbc:label="G_b3403"/>
+      <fbc:geneProduct fbc:id="G_b1702" fbc:name="G_b1702" fbc:label="G_b1702"/>
+      <fbc:geneProduct fbc:id="G_b2297" fbc:name="G_b2297" fbc:label="G_b2297"/>
+      <fbc:geneProduct fbc:id="G_b2458" fbc:name="G_b2458" fbc:label="G_b2458"/>
+      <fbc:geneProduct fbc:id="G_b1676" fbc:name="G_b1676" fbc:label="G_b1676"/>
+      <fbc:geneProduct fbc:id="G_b1854" fbc:name="G_b1854" fbc:label="G_b1854"/>
+      <fbc:geneProduct fbc:id="G_b4301" fbc:name="G_b4301" fbc:label="G_b4301"/>
+      <fbc:geneProduct fbc:id="G_b3386" fbc:name="G_b3386" fbc:label="G_b3386"/>
+      <fbc:geneProduct fbc:id="G_b4090" fbc:name="G_b4090" fbc:label="G_b4090"/>
+      <fbc:geneProduct fbc:id="G_b2914" fbc:name="G_b2914" fbc:label="G_b2914"/>
+      <fbc:geneProduct fbc:id="G_b3528" fbc:name="G_b3528" fbc:label="G_b3528"/>
+      <fbc:geneProduct fbc:id="G_b0721" fbc:name="G_b0721" fbc:label="G_b0721"/>
+      <fbc:geneProduct fbc:id="G_b0724" fbc:name="G_b0724" fbc:label="G_b0724"/>
+      <fbc:geneProduct fbc:id="G_b0722" fbc:name="G_b0722" fbc:label="G_b0722"/>
+      <fbc:geneProduct fbc:id="G_b0723" fbc:name="G_b0723" fbc:label="G_b0723"/>
+      <fbc:geneProduct fbc:id="G_b0728" fbc:name="G_b0728" fbc:label="G_b0728"/>
+      <fbc:geneProduct fbc:id="G_b0729" fbc:name="G_b0729" fbc:label="G_b0729"/>
+      <fbc:geneProduct fbc:id="G_b0008" fbc:name="G_b0008" fbc:label="G_b0008"/>
+      <fbc:geneProduct fbc:id="G_b2464" fbc:name="G_b2464" fbc:label="G_b2464"/>
+      <fbc:geneProduct fbc:id="G_b2465" fbc:name="G_b2465" fbc:label="G_b2465"/>
+      <fbc:geneProduct fbc:id="G_b2935" fbc:name="G_b2935" fbc:label="G_b2935"/>
+      <fbc:geneProduct fbc:id="G_b3919" fbc:name="G_b3919" fbc:label="G_b3919"/>
+    </fbc:listOfGeneProducts>
   </model>
 </sbml>
diff --git a/ECC2comp_old/box_positions.json b/ECC2comp_old/box_positions.json
new file mode 100644
index 0000000..266ff9d
--- /dev/null
+++ b/ECC2comp_old/box_positions.json
@@ -0,0 +1,343 @@
+{
+    "Core Metabolism": {
+        "name": "Map",
+        "background": "map1.svg",
+        "bg-size": 1.9999999999999998,
+        "box-size": 1,
+        "zoom": -6,
+        "pos": [
+            0,
+            2
+        ],
+        "boxes": {
+            "GlcUp": [
+                166.4194590317132,
+                103.1267066163677
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+            "GLCptspp": [
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+                56.674879841782015
+            ],
+            "GLCt2pp": [
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+                127.92114270445839
+            ],
+            "HEX1": [
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+                116.09552362845176
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+            "G6PDH2r": [
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+                70.70107297778294
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+                286.29771627774994
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+            "PGI": [
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+                176.63018887467717
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+            "GND": [
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+                190.42833909156678
+            ],
+            "PFK": [
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+                309.92756228623927
+            ],
+            "FBP": [
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+                304.75653009690586
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+            "RPE": [
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+                307.9845730160172
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+            "RPI": [
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+                311.2126159351285
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+            "GLYCDx": [
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+                442.39596788713493
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+            "FBA": [
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+                385.37439920891
+            ],
+            "TKT2": [
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+                416.1417318320227
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+            "TKT1": [
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+                389.7734743173548
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+            "TALA": [
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+                486.01846145691513
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+            "TPI": [
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+                469.1633005102476
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+            "G3PD2": [
+                535.04003013514,
+                607.7457275706989
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+            "G3PD5": [
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+                604.4298563280329
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+            "GLYK": [
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+                709.0169078462601
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+            "GlycUp": [
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+                677.7626717911479
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+            "PGM": [
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+            "EDD": [
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+                138.47421735518074
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+            "Growth": [
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+                647.2084037037548
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+            "h_pEx": [
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+                710.9290795227055
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+            "h2oEx": [
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+                834.8843885556005
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+            "PPC": [
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+                927.0570022499734
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+            "PPCK": [
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+                1001.0351352707742
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+            "PYK": [
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+            "PPS": [
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+                1020.2553615974159
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+            "MGSA": [
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+                897.5927306580032
+            ],
+            "GLYOX3": [
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+                1005.523225801431
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+            "LDH_D": [
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+            "FHL": [
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+            "PFL": [
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+            "PDH": [
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+            "PTAr": [
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+            "ACALD": [
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+            "ACKr": [
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+                1350.6817551094503
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+            "CS": [
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+                1980.0958821906336
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+            "SUCCt2_2pp": [
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+            "SUCCt3pp": [
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+            "FUM": [
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+            "MDH": [
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+                1542.1808164426823
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+            "MALS": [
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+                1597.0875113380907
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+            "SUCOAS": [
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+            "AKGDH": [
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+            "ICL": [
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+                1597.3761404495851
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+            "ACONTa": [
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+                1446.7435158765807
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+            "ACONTb": [
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+                1554.2682765559027
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+            "ICDHyr": [
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+                1665.0019589962178
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+            "ADK1": [
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+                1433.877628542097
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+            "ATPM": [
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+                1489.0729525489999
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+            "ATPS4rpp": [
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+                1489.7172671047472
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+            "O2Up": [
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+                1557.7784784461337
+            ],
+            "CYTBO3_4pp": [
+                1482.072952549,
+                1657.0816663467194
+            ],
+            "NADH16pp": [
+                1318.285811530017,
+                1731.7201359110954
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+            "NADH17pp": [
+                1438.9650886553175,
+                1771.8279998047778
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+            "NADTRHD": [
+                1304.1906861806772,
+                1858.4299235474864
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+            "THD2pp": [
+                1510.464477798014,
+                1919.301446102543
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+            "LacEx": [
+                1635.1147447337753,
+                1053.9151679749589
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+            "h2Ex": [
+                1637.0756635790278,
+                1093.3519217850617
+            ],
+            "FormEx": [
+                1635.507501721212,
+                1162.1589811014649
+            ]
+        }
+    }
+}
\ No newline at end of file
diff --git a/ECC2comp_old/glucose_anaerob_efm.scen b/ECC2comp_old/glucose_anaerob_efm.scen
new file mode 100644
index 0000000..08907fb
--- /dev/null
+++ b/ECC2comp_old/glucose_anaerob_efm.scen
@@ -0,0 +1 @@
+{"AcUp": [0.0, 0.0], "ATPM": [3.15, 3.15], "GlycUp": [0.0, 0.0], "SuccUp": [0.0, 0.0], "O2Up": [0.0, 0.0], "EDD": [0.0, 0.0], "PPS": [0.0, 0.0], "MALS": [0.0, 0.0], "ME2": [0.0, 0.0], "PPCK": [0.0, 0.0]}
\ No newline at end of file
diff --git a/ECC2comp_old/glucose_standard.scen b/ECC2comp_old/glucose_standard.scen
new file mode 100644
index 0000000..f18d340
--- /dev/null
+++ b/ECC2comp_old/glucose_standard.scen
@@ -0,0 +1 @@
+{"AcUp": [0.0, 0.0], "GlycUp": [0.0, 0.0], "SuccUp": [0.0, 0.0], "F6PA": [0.0, 0.0], "FBP": [0.0, 0.0], "G3PD5": [0.0, 0.0], "GLYCDx": [0.0, 0.0], "GLYK": [0.0, 0.0], "GLYOX3": [0.0, 0.0], "h2Ex": [0.0, 0.0], "ME1": [0.0, 0.0], "MGSA": [0.0, 0.0], "POX": [0.0, 0.0], "PPCK": [0.0, 0.0], "PPS": [0.0, 0.0], "SUCCt2_2pp": [0.0, 0.0]}
diff --git a/ECC2comp_old/map1.svg b/ECC2comp_old/map1.svg
new file mode 100644
index 0000000..81c58b5
--- /dev/null
+++ b/ECC2comp_old/map1.svg
@@ -0,0 +1,5527 @@
+<?xml version="1.0" encoding="UTF-8" standalone="no"?>
+<svg
+   xmlns:dc="http://purl.org/dc/elements/1.1/"
+   xmlns:cc="http://creativecommons.org/ns#"
+   xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
+   xmlns:svg="http://www.w3.org/2000/svg"
+   xmlns="http://www.w3.org/2000/svg"
+   viewBox="0 0 267 288"
+   id="svg2"
+   height="288mm"
+   width="267mm"
+   version="1.0">
+  <metadata
+     id="metadata2755">
+    <rdf:RDF>
+      <cc:Work
+         rdf:about="">
+        <dc:format>image/svg+xml</dc:format>
+        <dc:type
+           rdf:resource="http://purl.org/dc/dcmitype/StillImage" />
+        <dc:title></dc:title>
+      </cc:Work>
+    </rdf:RDF>
+  </metadata>
+  <defs
+     id="defs4">
+    <pattern
+       y="0"
+       x="0"
+       height="6"
+       width="6"
+       patternUnits="userSpaceOnUse"
+       id="EMFhbasepattern" />
+  </defs>
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diff --git a/ECC2comp_old/meta.json b/ECC2comp_old/meta.json
new file mode 100644
index 0000000..fd979c2
--- /dev/null
+++ b/ECC2comp_old/meta.json
@@ -0,0 +1 @@
+{"description": "EColiCore2 compressed\nMetabolic core model of Escherichia coli str. K-12 substr. MG1655. Compressed  version of EColiCore2 obtained from MATLAB CellNetAnalyzer function CNAcompressMFNetwork\n\nContains:\n94 metabolites\n122 reactions\n\nPublication:\nH\u00e4dicke, O., Klamt, S. EColiCore2: a reference network model of the central metabolism of Escherichia coli and relationships to its genome-scale parent model. Sci Rep 7, 39647 (2017). https://doi.org/10.1038/srep39647", "format version": 1}
\ No newline at end of file
diff --git a/ECC2comp_old/model.sbml b/ECC2comp_old/model.sbml
new file mode 100644
index 0000000..b324070
--- /dev/null
+++ b/ECC2comp_old/model.sbml
@@ -0,0 +1,1238 @@
+<?xml version="1.0" encoding="UTF-8"?>
+<sbml xmlns="http://www.sbml.org/sbml/level3/version1/core" xmlns:fbc="http://www.sbml.org/sbml/level3/version1/fbc/version2" metaid="meta_" sboTerm="SBO:0000624" level="3" version="1" fbc:required="false">
+  <model metaid="meta_CNA_ECC2comp" id="CNA_ECC2comp" name="ECC2comp" fbc:strict="true">
+    <listOfUnitDefinitions>
+      <unitDefinition id="mmol_per_gDW_per_hr">
+        <listOfUnits>
+          <unit kind="mole" exponent="1" scale="-3" multiplier="1"/>
+          <unit kind="gram" exponent="-1" scale="0" multiplier="1"/>
+          <unit kind="second" exponent="-1" scale="0" multiplier="3600"/>
+        </listOfUnits>
+      </unitDefinition>
+    </listOfUnitDefinitions>
+    <listOfCompartments>
+      <compartment id="External_Species" constant="true"/>
+      <compartment id="Internal_Species" constant="true"/>
+    </listOfCompartments>
+    <listOfSpecies>
+      <species id="M_Biomass" name="Biomass" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_13dpg_c" name="3-Phospho-D-glyceroylphosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_2ddg6p_c" name="2-Dehydro-3-deoxy-D-gluconate6-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_2pg_c" name="D-Glycerate2-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_3pg_c" name="3-Phospho-D-glycerate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_4CRSOL_ex" name="M_4CRSOL_ex" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_5DRIB_ex" name="M_5DRIB_ex" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_6pgc_c" name="6-Phospho-D-gluconate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_6pgl_c" name="6-phospho-D-glucono-1,5-lactone" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_ac_c" name="Acetate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_ac_ex" name="M_ac_ex" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_acald_c" name="Acetaldehyde" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_accoa_c" name="Acetyl-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_acon_DASH_C_c" name="cis-Aconitate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_actp_c" name="Acetylphosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_adp_c" name="ADP" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_akg_c" name="2-Oxoglutarate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_AMOB_ex" name="M_AMOB_ex" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_amp_c" name="AMP" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
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+      <species id="M_cit_c" name="Citrate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_cl_ex" name="M_cl_ex" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_co2_c" name="CO2" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_co2_ex" name="M_co2_ex" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_coa_c" name="CoenzymeA" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_cobalt2_ex" name="M_cobalt2_ex" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_cu2_ex" name="M_cu2_ex" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_dha_c" name="Dihydroxyacetone" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
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+      <species id="M_e4p_c" name="D-Erythrose4-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_etoh_c" name="Ethanol" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
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+      <species id="M_f6p_c" name="D-Fructose6-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_fdp_c" name="D-Fructose1,6-bisphosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
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+      <species id="M_fum_c" name="Fumarate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
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+      <species id="M_g6p_c" name="D-Glucose6-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_glc_DASH_D_c" name="D-Glucose" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_glc_DASH_D_ex" name="M_glc_DASH_D_ex" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_glc_DASH_D_p" name="D-Glucose" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_glx_c" name="Glyoxylate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_glyc_c" name="Glycerol" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_glyc_ex" name="M_glyc_ex" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_glyc3p_c" name="Glycerol3-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_h_c" name="H+" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_h_ex" name="M_h_ex" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_h_p" name="H+" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_h2_c" name="H2" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_h2_ex" name="M_h2_ex" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_h2o_c" name="H2O" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_h2o_ex" name="M_h2o_ex" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_icit_c" name="Isocitrate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_k_ex" name="M_k_ex" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_lac_DASH_D_c" name="D-Lactate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_lac_ex" name="M_lac_ex" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_mal_DASH_L_c" name="L-Malate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_meoh_ex" name="M_meoh_ex" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_mg2_ex" name="M_mg2_ex" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_mn2_ex" name="M_mn2_ex" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_mobd_ex" name="M_mobd_ex" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_mql8_c" name="Menaquinol8" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_mqn8_c" name="Menaquinone8" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_mthgxl_c" name="Methylglyoxal" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_MTHTHF_ex" name="M_MTHTHF_ex" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_nad_c" name="Nicotinamideadeninedinucleotide" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_nadh_c" name="Nicotinamideadeninedinucleotide-reduced" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_nadp_c" name="Nicotinamideadeninedinucleotidephosphate" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_nadph_c" name="Nicotinamideadeninedinucleotidephosphate-reduced" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_nh4_ex" name="M_nh4_ex" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_ni2_ex" name="M_ni2_ex" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_o2_c" name="O2" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_o2_ex" name="M_o2_ex" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_oaa_c" name="Oxaloacetate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_pep_c" name="Phosphoenolpyruvate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_pi_c" name="Phosphate" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_pi_ex" name="M_pi_ex" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_pyr_c" name="Pyruvate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_q8_c" name="Ubiquinone-8" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_q8h2_c" name="Ubiquinol-8" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_r5p_c" name="alpha-D-Ribose5-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_ru5p_DASH_D_c" name="D-Ribulose5-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_s7p_c" name="Sedoheptulose7-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_so4_ex" name="M_so4_ex" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_succ_c" name="Succinate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_succ_ex" name="M_succ_ex" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_succ_p" name="Succinate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_succoa_c" name="Succinyl-CoA" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_xu5p_DASH_D_c" name="D-Xylulose5-phosphate" compartment="Internal_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+      <species id="M_zn2_ex" name="M_zn2_ex" compartment="External_Species" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
+    </listOfSpecies>
+    <listOfParameters>
+      <parameter sboTerm="SBO:0000626" id="cobra_default_lb" value="-1000" constant="true"/>
+      <parameter sboTerm="SBO:0000626" id="cobra_default_ub" value="1000" constant="true"/>
+      <parameter sboTerm="SBO:0000626" id="cobra_0_bound" value="0" constant="true"/>
+      <parameter sboTerm="SBO:0000626" id="minus_inf" value="-INF" constant="true"/>
+      <parameter sboTerm="SBO:0000626" id="plus_inf" value="INF" constant="true"/>
+      <parameter sboTerm="SBO:0000625" id="R_AcUp_upper_bound" value="10" units="mmol_per_gDW_per_hr" constant="true"/>
+      <parameter sboTerm="SBO:0000625" id="R_CO2Up_upper_bound" value="10" units="mmol_per_gDW_per_hr" constant="true"/>
+      <parameter sboTerm="SBO:0000625" id="R_GlcUp_upper_bound" value="10" units="mmol_per_gDW_per_hr" constant="true"/>
+      <parameter sboTerm="SBO:0000625" id="R_GlycUp_upper_bound" value="10" units="mmol_per_gDW_per_hr" constant="true"/>
+      <parameter sboTerm="SBO:0000625" id="R_SuccUp_upper_bound" value="10" units="mmol_per_gDW_per_hr" constant="true"/>
+      <parameter sboTerm="SBO:0000625" id="R_ATPM_lower_bound" value="3.15" units="mmol_per_gDW_per_hr" constant="true"/>
+    </listOfParameters>
+    <listOfReactions>
+      <reaction metaid="meta_R_EX_Biomass" sboTerm="SBO:0000627" id="R_EX_Biomass" name="EX_Biomass" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_Biomass" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction metaid="meta_R_EX_4CRSOL_ex" sboTerm="SBO:0000627" id="R_EX_4CRSOL_ex" name="EX_4CRSOL_ex" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_4CRSOL_ex" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction metaid="meta_R_EX_5DRIB_ex" sboTerm="SBO:0000627" id="R_EX_5DRIB_ex" name="EX_5DRIB_ex" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_5DRIB_ex" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction metaid="meta_R_EX_ac_ex" sboTerm="SBO:0000627" id="R_EX_ac_ex" name="EX_ac_ex" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_ac_ex" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction metaid="meta_R_EX_adp_c" sboTerm="SBO:0000627" id="R_EX_adp_c" name="EX_adp_c" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction metaid="meta_R_EX_AMOB_ex" sboTerm="SBO:0000627" id="R_EX_AMOB_ex" name="EX_AMOB_ex" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_AMOB_ex" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction metaid="meta_R_EX_ca2_ex" sboTerm="SBO:0000627" id="R_EX_ca2_ex" name="EX_ca2_ex" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_ca2_ex" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction metaid="meta_R_EX_cl_ex" sboTerm="SBO:0000627" id="R_EX_cl_ex" name="EX_cl_ex" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_cl_ex" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction metaid="meta_R_EX_co2_ex" sboTerm="SBO:0000627" id="R_EX_co2_ex" name="EX_co2_ex" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_co2_ex" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction metaid="meta_R_EX_coa_c" sboTerm="SBO:0000627" id="R_EX_coa_c" name="EX_coa_c" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction metaid="meta_R_EX_cobalt2_ex" sboTerm="SBO:0000627" id="R_EX_cobalt2_ex" name="EX_cobalt2_ex" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_cobalt2_ex" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction metaid="meta_R_EX_cu2_ex" sboTerm="SBO:0000627" id="R_EX_cu2_ex" name="EX_cu2_ex" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_cu2_ex" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction metaid="meta_R_EX_etoh_ex" sboTerm="SBO:0000627" id="R_EX_etoh_ex" name="EX_etoh_ex" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_etoh_ex" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction metaid="meta_R_EX_fe2_ex" sboTerm="SBO:0000627" id="R_EX_fe2_ex" name="EX_fe2_ex" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_fe2_ex" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction metaid="meta_R_EX_fe3_ex" sboTerm="SBO:0000627" id="R_EX_fe3_ex" name="EX_fe3_ex" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_fe3_ex" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction metaid="meta_R_EX_for_ex" sboTerm="SBO:0000627" id="R_EX_for_ex" name="EX_for_ex" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_for_ex" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction metaid="meta_R_EX_glc_DASH_D_ex" sboTerm="SBO:0000627" id="R_EX_glc_DASH_D_ex" name="EX_glc_DASH_D_ex" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_glc_DASH_D_ex" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction metaid="meta_R_EX_glyc_ex" sboTerm="SBO:0000627" id="R_EX_glyc_ex" name="EX_glyc_ex" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_glyc_ex" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction metaid="meta_R_EX_h_ex" sboTerm="SBO:0000627" id="R_EX_h_ex" name="EX_h_ex" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_h_ex" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction metaid="meta_R_EX_h2_ex" sboTerm="SBO:0000627" id="R_EX_h2_ex" name="EX_h2_ex" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_h2_ex" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction metaid="meta_R_EX_h2o_ex" sboTerm="SBO:0000627" id="R_EX_h2o_ex" name="EX_h2o_ex" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_h2o_ex" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction metaid="meta_R_EX_k_ex" sboTerm="SBO:0000627" id="R_EX_k_ex" name="EX_k_ex" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_k_ex" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction metaid="meta_R_EX_lac_ex" sboTerm="SBO:0000627" id="R_EX_lac_ex" name="EX_lac_ex" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_lac_ex" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction metaid="meta_R_EX_meoh_ex" sboTerm="SBO:0000627" id="R_EX_meoh_ex" name="EX_meoh_ex" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_meoh_ex" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction metaid="meta_R_EX_mg2_ex" sboTerm="SBO:0000627" id="R_EX_mg2_ex" name="EX_mg2_ex" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_mg2_ex" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction metaid="meta_R_EX_mn2_ex" sboTerm="SBO:0000627" id="R_EX_mn2_ex" name="EX_mn2_ex" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_mn2_ex" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction metaid="meta_R_EX_mobd_ex" sboTerm="SBO:0000627" id="R_EX_mobd_ex" name="EX_mobd_ex" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_mobd_ex" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction metaid="meta_R_EX_mqn8_c" sboTerm="SBO:0000627" id="R_EX_mqn8_c" name="EX_mqn8_c" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_mqn8_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction metaid="meta_R_EX_MTHTHF_ex" sboTerm="SBO:0000627" id="R_EX_MTHTHF_ex" name="EX_MTHTHF_ex" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_MTHTHF_ex" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction metaid="meta_R_EX_nad_c" sboTerm="SBO:0000627" id="R_EX_nad_c" name="EX_nad_c" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction metaid="meta_R_EX_nadp_c" sboTerm="SBO:0000627" id="R_EX_nadp_c" name="EX_nadp_c" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction metaid="meta_R_EX_nh4_ex" sboTerm="SBO:0000627" id="R_EX_nh4_ex" name="EX_nh4_ex" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_nh4_ex" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction metaid="meta_R_EX_ni2_ex" sboTerm="SBO:0000627" id="R_EX_ni2_ex" name="EX_ni2_ex" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_ni2_ex" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction metaid="meta_R_EX_o2_ex" sboTerm="SBO:0000627" id="R_EX_o2_ex" name="EX_o2_ex" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_o2_ex" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction metaid="meta_R_EX_pi_c" sboTerm="SBO:0000627" id="R_EX_pi_c" name="EX_pi_c" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction metaid="meta_R_EX_pi_ex" sboTerm="SBO:0000627" id="R_EX_pi_ex" name="EX_pi_ex" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_pi_ex" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction metaid="meta_R_EX_q8_c" sboTerm="SBO:0000627" id="R_EX_q8_c" name="EX_q8_c" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_q8_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction metaid="meta_R_EX_so4_ex" sboTerm="SBO:0000627" id="R_EX_so4_ex" name="EX_so4_ex" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_so4_ex" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction metaid="meta_R_EX_succ_ex" sboTerm="SBO:0000627" id="R_EX_succ_ex" name="EX_succ_ex" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_succ_ex" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction metaid="meta_R_EX_zn2_ex" sboTerm="SBO:0000627" id="R_EX_zn2_ex" name="EX_zn2_ex" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_zn2_ex" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+      </reaction>
+      <reaction id="R_Growth" name="Growth" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_3pg_c" stoichiometry="1.7178" constant="true"/>
+          <speciesReference species="M_accoa_c" stoichiometry="3.8579" constant="true"/>
+          <speciesReference species="M_akg_c" stoichiometry="1.0752" constant="true"/>
+          <speciesReference species="M_atp_c" stoichiometry="63.2803" constant="true"/>
+          <speciesReference species="M_ca2_ex" stoichiometry="0.005205" constant="true"/>
+          <speciesReference species="M_cl_ex" stoichiometry="0.005205" constant="true"/>
+          <speciesReference species="M_cobalt2_ex" stoichiometry="2.5e-05" constant="true"/>
+          <speciesReference species="M_cu2_ex" stoichiometry="0.000709" constant="true"/>
+          <speciesReference species="M_dhap_c" stoichiometry="0.002278" constant="true"/>
+          <speciesReference species="M_e4p_c" stoichiometry="0.38135" constant="true"/>
+          <speciesReference species="M_f6p_c" stoichiometry="0.094488" constant="true"/>
+          <speciesReference species="M_fe2_ex" stoichiometry="0.008253" constant="true"/>
+          <speciesReference species="M_fe3_ex" stoichiometry="0.007808" constant="true"/>
+          <speciesReference species="M_glyc3p_c" stoichiometry="0.13903" constant="true"/>
+          <speciesReference species="M_h_p" stoichiometry="1.4007" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="40.8722" constant="true"/>
+          <speciesReference species="M_k_ex" stoichiometry="0.19519" constant="true"/>
+          <speciesReference species="M_mg2_ex" stoichiometry="0.008675" constant="true"/>
+          <speciesReference species="M_mn2_ex" stoichiometry="0.000691" constant="true"/>
+          <speciesReference species="M_mobd_ex" stoichiometry="0.000129" constant="true"/>
+          <speciesReference species="M_nadh_c" stoichiometry="1.8822" constant="true"/>
+          <speciesReference species="M_nadph_c" stoichiometry="13.225" constant="true"/>
+          <speciesReference species="M_nh4_ex" stoichiometry="10.8007" constant="true"/>
+          <speciesReference species="M_ni2_ex" stoichiometry="0.000323" constant="true"/>
+          <speciesReference species="M_oaa_c" stoichiometry="2.9276" constant="true"/>
+          <speciesReference species="M_pep_c" stoichiometry="0.82896" constant="true"/>
+          <speciesReference species="M_pi_ex" stoichiometry="0.96451" constant="true"/>
+          <speciesReference species="M_pyr_c" stoichiometry="2.8394" constant="true"/>
+          <speciesReference species="M_r5p_c" stoichiometry="0.93398" constant="true"/>
+          <speciesReference species="M_ru5p_DASH_D_c" stoichiometry="0.039804" constant="true"/>
+          <speciesReference species="M_so4_ex" stoichiometry="0.25221" constant="true"/>
+          <speciesReference species="M_succoa_c" stoichiometry="0.52486" constant="true"/>
+          <speciesReference species="M_zn2_ex" stoichiometry="0.000341" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_Biomass" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_4CRSOL_ex" stoichiometry="0.000223" constant="true"/>
+          <speciesReference species="M_5DRIB_ex" stoichiometry="0.000671" constant="true"/>
+          <speciesReference species="M_ac_c" stoichiometry="0.58258" constant="true"/>
+          <speciesReference species="M_adp_c" stoichiometry="60.6288" constant="true"/>
+          <speciesReference species="M_AMOB_ex" stoichiometry="2e-06" constant="true"/>
+          <speciesReference species="M_amp_c" stoichiometry="2.6515" constant="true"/>
+          <speciesReference species="M_co2_c" stoichiometry="1.7972" constant="true"/>
+          <speciesReference species="M_coa_c" stoichiometry="4.3828" constant="true"/>
+          <speciesReference species="M_fum_c" stoichiometry="0.70838" constant="true"/>
+          <speciesReference species="M_g3p_c" stoichiometry="0.054008" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="51.2225" constant="true"/>
+          <speciesReference species="M_meoh_ex" stoichiometry="2e-06" constant="true"/>
+          <speciesReference species="M_MTHTHF_ex" stoichiometry="0.000448" constant="true"/>
+          <speciesReference species="M_nad_c" stoichiometry="1.8822" constant="true"/>
+          <speciesReference species="M_nadp_c" stoichiometry="13.225" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="70.0155" constant="true"/>
+          <speciesReference species="M_succ_c" stoichiometry="0.85927" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ACALD" name="R_ACALD" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_accoa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_acald_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_AcEx" name="R_AcEx" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_ac_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_ac_ex" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_p" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ACKr" name="R_ACKr" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_actp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_ac_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ACONTa" name="R_ACONTa" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_cit_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_acon_DASH_C_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ACONTb" name="R_ACONTb" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_acon_DASH_C_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_icit_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction metaid="meta_R_AcUp" id="R_AcUp" name="R_AcUp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="R_AcUp_upper_bound">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_AcUp">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/cnapy-default/(0.0, 0.0)"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+        <listOfReactants>
+          <speciesReference species="M_ac_ex" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_p" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_ac_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ADK1" name="R_ADK1" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_amp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="2" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_AKGDH" name="R_AKGDH" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_akg_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_succoa_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ALCD2x" name="R_ALCD2x" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_acald_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_etoh_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction metaid="meta_R_ATPM" id="R_ATPM" name="R_ATPM" reversible="false" fast="false" fbc:lowerFluxBound="R_ATPM_lower_bound" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ATPS4rpp" name="R_ATPS4rpp" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_p" stoichiometry="4" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="3" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_CO2Ex" name="R_CO2Ex" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_co2_ex" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_CO2Up" name="R_CO2Up" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="R_CO2Up_upper_bound">
+        <listOfReactants>
+          <speciesReference species="M_co2_ex" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_CS" name="R_CS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_accoa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_oaa_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_cit_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_CYTBO3_4pp" name="R_CYTBO3_4pp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_h_c" stoichiometry="4" constant="true"/>
+          <speciesReference species="M_o2_c" stoichiometry="0.5" constant="true"/>
+          <speciesReference species="M_q8h2_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h_p" stoichiometry="4" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_q8_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_EDA" name="R_EDA" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_2ddg6p_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_g3p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_EDD" name="R_EDD" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_6pgc_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_2ddg6p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ENO" name="R_ENO" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_2pg_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pep_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_EthEx" name="R_EthEx" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_etoh_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_etoh_ex" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_F6PA" name="R_F6PA" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_dha_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_g3p_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_f6p_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_FBA" name="R_FBA" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_fdp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_dhap_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_g3p_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_FBP" name="R_FBP" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_fdp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_f6p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_FHL" name="R_FHL" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_for_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_FormEx" name="R_FormEx" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_for_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_for_ex" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_FRD2" name="R_FRD2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_fum_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_mql8_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_mqn8_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_succ_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_FUM" name="R_FUM" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_fum_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_mal_DASH_L_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_G3PD2" name="R_G3PD2" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_glyc3p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_dhap_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_G3PD5" name="R_G3PD5" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_glyc3p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_q8_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_dhap_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_q8h2_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_G6PDH2r" name="R_G6PDH2r" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_g6p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_6pgl_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_GAPD" name="R_GAPD" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_g3p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_13dpg_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_GLCptspp" name="R_GLCptspp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_glc_DASH_D_p" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pep_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_g6p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_GLCt2pp" name="R_GLCt2pp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_glc_DASH_D_p" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_p" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_glc_DASH_D_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_GlcUp" name="R_GlcUp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="R_GlcUp_upper_bound">
+        <listOfReactants>
+          <speciesReference species="M_glc_DASH_D_ex" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_glc_DASH_D_p" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_GLYCDx" name="R_GLYCDx" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_glyc_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_dha_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction metaid="meta_R_GlycUp" id="R_GlycUp" name="R_GlycUp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="R_GlycUp_upper_bound">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_GlycUp">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/cnapy-default/(0.0, 0.0)"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+        <listOfReactants>
+          <speciesReference species="M_glyc_ex" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_glyc_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_GLYK" name="R_GLYK" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_glyc_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_glyc3p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_GLYOX3" name="R_GLYOX3" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_mthgxl_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_lac_DASH_D_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_GND" name="R_GND" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_6pgc_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_ru5p_DASH_D_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_h_pEx" name="R_h_pEx" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_h_p" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h_ex" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_h2Ex" name="R_h2Ex" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_h2_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h2_ex" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_h2oEx" name="R_h2oEx" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h2o_ex" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_HEX1" name="R_HEX1" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_glc_DASH_D_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_g6p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ICDHyr" name="R_ICDHyr" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_icit_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_akg_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ICL" name="R_ICL" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_icit_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_glx_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_succ_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_LacEx" name="R_LacEx" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_lac_DASH_D_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h_p" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_lac_ex" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_LDH_D" name="R_LDH_D" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_lac_DASH_D_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_MALS" name="R_MALS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_accoa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_glx_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_mal_DASH_L_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_MDH" name="R_MDH" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_mal_DASH_L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_oaa_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ME1" name="R_ME1" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_mal_DASH_L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_ME2" name="R_ME2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_mal_DASH_L_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_MGSA" name="R_MGSA" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_dhap_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_mthgxl_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_NADH16pp" name="R_NADH16pp" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_h_c" stoichiometry="4" constant="true"/>
+          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_q8_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h_p" stoichiometry="3" constant="true"/>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_q8h2_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_NADH17pp" name="R_NADH17pp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_h_c" stoichiometry="4" constant="true"/>
+          <speciesReference species="M_mqn8_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h_p" stoichiometry="3" constant="true"/>
+          <speciesReference species="M_mql8_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_NADTRHD" name="R_NADTRHD" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_O2Up" name="R_O2Up" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_o2_ex" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_o2_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PDH" name="R_PDH" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_accoa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PFK" name="R_PFK" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_f6p_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_fdp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PFL" name="R_PFL" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_accoa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_for_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PGI" name="R_PGI" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_g6p_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_f6p_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PGK" name="R_PGK" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_13dpg_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_3pg_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PGL" name="R_PGL" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_6pgl_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_6pgc_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PGM" name="R_PGM" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_3pg_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_2pg_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_POX" name="R_POX" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_q8_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_ac_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_q8h2_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PPC" name="R_PPC" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pep_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_oaa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PPCK" name="R_PPCK" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_oaa_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pep_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PPS" name="R_PPS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_amp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_pep_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PTAr" name="R_PTAr" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_accoa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_actp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_PYK" name="R_PYK" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pep_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_RPE" name="R_RPE" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_ru5p_DASH_D_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_xu5p_DASH_D_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_RPI" name="R_RPI" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_r5p_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_ru5p_DASH_D_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_SuccEx" name="R_SuccEx" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_succ_p" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_succ_ex" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_SUCCt2_2pp" name="R_SUCCt2_2pp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_h_p" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_succ_p" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_succ_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_SUCCt3pp" name="R_SUCCt3pp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_h_p" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_succ_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_succ_p" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction metaid="meta_R_SuccUp" id="R_SuccUp" name="R_SuccUp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="R_SuccUp_upper_bound">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_R_SuccUp">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/cnapy-default/(0.0, 0.0)"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+        <listOfReactants>
+          <speciesReference species="M_succ_ex" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_succ_p" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_SUCDi" name="R_SUCDi" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_q8_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_succ_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_fum_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_q8h2_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_SUCOAS" name="R_SUCOAS" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_succoa_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_succ_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_TALA" name="R_TALA" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_g3p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_s7p_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_e4p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_f6p_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_THD2pp" name="R_THD2pp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_h_p" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_h_c" stoichiometry="2" constant="true"/>
+          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_TKT1" name="R_TKT1" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_r5p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_xu5p_DASH_D_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_g3p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_s7p_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_TKT2" name="R_TKT2" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_e4p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_xu5p_DASH_D_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_f6p_c" stoichiometry="1" constant="true"/>
+          <speciesReference species="M_g3p_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction id="R_TPI" name="R_TPI" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
+        <listOfReactants>
+          <speciesReference species="M_dhap_c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="M_g3p_c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+    </listOfReactions>
+    <fbc:listOfObjectives fbc:activeObjective="obj">
+      <fbc:objective fbc:id="obj" fbc:type="maximize">
+        <fbc:listOfFluxObjectives>
+          <fbc:fluxObjective fbc:reaction="R_Growth" fbc:coefficient="1"/>
+        </fbc:listOfFluxObjectives>
+      </fbc:objective>
+    </fbc:listOfObjectives>
+  </model>
+</sbml>