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knitr::opts_chunk$set(
  collapse = TRUE,
  comment = "#>",
  fig.path = "man/figures/README-",
  out.width = "100%"
)

HEART

HEART, a statistical combination test, can easily capture the various source of the difference beyond mean expression changesand facilitate the accuracy, robustness, and efficiency of single-cell DE analysis.

Installation

First, install the packages: data.table, fBasics, matrixTests. Then, install the package HEART.

install.packages("data.table")
install.packages("fBasics")
install.packages("matrixTests")
install.packages("~path/HEART_1.1.0.tar.gz")

Example

This is a basic example which shows you how to use HEART.

library(data.table)
library(fBasics)
library(matrixTests)
library(HEART)
data("example")

expression[1:5,1:5]

head(cell.data)

"example" data has two datasets: expression: a counts matrix. cell.data: a data frame containing information on individual cells.


result=heart(counts = expression,cell.data = cell.data)

head(result)