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This repository has been archived by the owner on Mar 17, 2023. It is now read-only.
Currently, sencha translate uses a simple match of whether 100% of the k-mers from the reading frame, match the reference proteome. But a "Franken k-mer" situation can happen where the reading frame has 100% match, but the k-mers are all from different genes. Using sourmash search --containment would only search for "consecutive" k-mers that all appear in a single gene (or maybe family of genes??) and would be an improvement over the current method.
Maybe use sourmash lca search --containment by hacking the Least Common Ancestor (LCA) code to use gene/protein families instead of individual genes, so that the matches could be on a per-gene family level.
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Currently,
sencha translate
uses a simple match of whether 100% of the k-mers from the reading frame, match the reference proteome. But a "Franken k-mer" situation can happen where the reading frame has 100% match, but the k-mers are all from different genes. Usingsourmash search --containment
would only search for "consecutive" k-mers that all appear in a single gene (or maybe family of genes??) and would be an improvement over the current method.Thanks to @bluegenes for the idea!
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