diff --git a/ci/test/00_setup_env_mac.sh b/ci/test/00_setup_env_mac.sh
index b40c75d33b2da5..086b74a39e4613 100755
--- a/ci/test/00_setup_env_mac.sh
+++ b/ci/test/00_setup_env_mac.sh
@@ -8,7 +8,7 @@ export LC_ALL=C.UTF-8
 
 export CONTAINER_NAME=ci_macos_cross
 export HOST=x86_64-apple-darwin
-export PACKAGES="cmake libz-dev python3-setuptools zip"
+export PACKAGES="cmake libz-dev zip"
 export XCODE_VERSION=12.2
 export XCODE_BUILD_ID=12B45b
 export RUN_UNIT_TESTS=false
diff --git a/depends/README.md b/depends/README.md
index 062323195a0d68..77b047e4c1ea3d 100644
--- a/depends/README.md
+++ b/depends/README.md
@@ -47,7 +47,7 @@ The paths are automatically configured and no other options are needed unless ta
 
 #### For macOS cross compilation
 
-    sudo apt-get install curl bsdmainutils cmake libz-dev python3-setuptools zip
+    sudo apt-get install curl bsdmainutils cmake libz-dev zip
 
 Note: You must obtain the macOS SDK before proceeding with a cross-compile.
 Under the depends directory, create a subdirectory named `SDKs`.