diff --git a/.github/workflows/deploy_branch.yml b/.github/workflows/deploy_branch.yml
index ff1be3145d..24d77d8118 100644
--- a/.github/workflows/deploy_branch.yml
+++ b/.github/workflows/deploy_branch.yml
@@ -9,7 +9,7 @@ jobs:
 
     strategy:
       matrix:
-        python-version: [3.9]
+        python-version: ["3.11"]
 
     steps:
     - name: Set up Python ${{ matrix.python-version }}
diff --git a/.github/workflows/deploy_protected.yml b/.github/workflows/deploy_protected.yml
index 881a4eb77a..7f787e56c3 100644
--- a/.github/workflows/deploy_protected.yml
+++ b/.github/workflows/deploy_protected.yml
@@ -36,7 +36,7 @@ jobs:
 
     strategy:
       matrix:
-        python-version: [3.9]
+        python-version: ["3.11"]
 
     steps:
     - name: Set up Python ${{ matrix.python-version }}
diff --git a/.github/workflows/deploy_release.yml b/.github/workflows/deploy_release.yml
index de7a073cc2..ab7b68645b 100644
--- a/.github/workflows/deploy_release.yml
+++ b/.github/workflows/deploy_release.yml
@@ -12,7 +12,7 @@ jobs:
 
     strategy:
       matrix:
-        python-version: [3.9]
+        python-version: ["3.11"]
 
     environment:
       name: pypi
diff --git a/.github/workflows/test_benchmark_collection_models.yml b/.github/workflows/test_benchmark_collection_models.yml
index ab29938a12..023fe077e6 100644
--- a/.github/workflows/test_benchmark_collection_models.yml
+++ b/.github/workflows/test_benchmark_collection_models.yml
@@ -22,7 +22,7 @@ jobs:
     strategy:
       fail-fast: false
       matrix:
-        python-version: [ "3.9" ]
+        python-version: [ "3.11" ]
         extract_subexpressions: ["true", "false"]
     env:
       AMICI_EXTRACT_CSE: ${{ matrix.extract_subexpressions }}
diff --git a/.github/workflows/test_doc.yml b/.github/workflows/test_doc.yml
index a4fe10de22..5fcf490eb7 100644
--- a/.github/workflows/test_doc.yml
+++ b/.github/workflows/test_doc.yml
@@ -20,7 +20,7 @@ jobs:
 
     strategy:
       matrix:
-        python-version: [3.9]
+        python-version: ["3.11"]
 
     steps:
     - name: Set up Python ${{ matrix.python-version }}
diff --git a/.github/workflows/test_install.yml b/.github/workflows/test_install.yml
index 0c624a33e5..9e1717d962 100644
--- a/.github/workflows/test_install.yml
+++ b/.github/workflows/test_install.yml
@@ -9,7 +9,7 @@ jobs:
 
     strategy:
       matrix:
-        python-version: [3.9]
+        python-version: ["3.11"]
 
     steps:
     - name: Set up Python ${{ matrix.python-version }}
@@ -50,7 +50,7 @@ jobs:
 
     strategy:
       matrix:
-        python-version: [3.9]
+        python-version: ["3.11"]
 
     steps:
     - name: Set up Python ${{ matrix.python-version }}
@@ -83,7 +83,7 @@ jobs:
 
     strategy:
       matrix:
-        python-version: [3.9]
+        python-version: ["3.11"]
 
     steps:
     - name: Set up Python ${{ matrix.python-version }}
diff --git a/.github/workflows/test_performance.yml b/.github/workflows/test_performance.yml
index c02245224c..6b66698d10 100644
--- a/.github/workflows/test_performance.yml
+++ b/.github/workflows/test_performance.yml
@@ -23,7 +23,7 @@ jobs:
 
     strategy:
       matrix:
-        python-version: [3.9]
+        python-version: ["3.11"]
 
     steps:
     - name: Set up Python ${{ matrix.python-version }}
diff --git a/.github/workflows/test_petab_test_suite.yml b/.github/workflows/test_petab_test_suite.yml
index b6465d554b..7e9a93c494 100644
--- a/.github/workflows/test_petab_test_suite.yml
+++ b/.github/workflows/test_petab_test_suite.yml
@@ -22,7 +22,7 @@ jobs:
 
     strategy:
       matrix:
-        python-version: [3.9]
+        python-version: ["3.11"]
 
     steps:
       - name: Set up Python ${{ matrix.python-version }}
diff --git a/.github/workflows/test_pypi.yml b/.github/workflows/test_pypi.yml
index fecda3edb0..1e91019c6f 100644
--- a/.github/workflows/test_pypi.yml
+++ b/.github/workflows/test_pypi.yml
@@ -11,7 +11,7 @@ jobs:
     strategy:
       fail-fast: false
       matrix:
-        python-version: ["3.9", "3.10", "3.11", "3.12"]
+        python-version: ["3.10", "3.11", "3.12"]
         os: [ubuntu-22.04, macos-latest]
 
     runs-on: ${{ matrix.os }}
diff --git a/.github/workflows/test_python_cplusplus.yml b/.github/workflows/test_python_cplusplus.yml
index f729d47867..5714a37b21 100644
--- a/.github/workflows/test_python_cplusplus.yml
+++ b/.github/workflows/test_python_cplusplus.yml
@@ -15,7 +15,7 @@ jobs:
 
     strategy:
       matrix:
-        python-version: [ "3.9" ]
+        python-version: [ "3.11" ]
 
     steps:
     - name: Cache
@@ -117,7 +117,7 @@ jobs:
 
     strategy:
       matrix:
-        python-version: [ "3.9" ]
+        python-version: [ "3.10" ]
 
     steps:
     - name: Set up Python ${{ matrix.python-version }}
@@ -193,7 +193,7 @@ jobs:
 
     strategy:
       matrix:
-        python-version: [ "3.9" ]
+        python-version: [ "3.11" ]
 
     steps:
     - name: Set up Python ${{ matrix.python-version }}
@@ -233,7 +233,7 @@ jobs:
     - name: Set up Python
       uses: actions/setup-python@v5
       with:
-        python-version: 3.9
+        python-version: "3.11"
 
     - uses: actions/checkout@v4
     - run: git fetch --prune --unshallow
@@ -282,7 +282,7 @@ jobs:
     - name: Set up Python
       uses: actions/setup-python@v5
       with:
-        python-version: 3.9
+        python-version: "3.11"
 
     - uses: actions/checkout@v4
     - run: git fetch --prune --unshallow
diff --git a/.github/workflows/test_python_ver_matrix.yml b/.github/workflows/test_python_ver_matrix.yml
index 414daadccc..01d455b18a 100644
--- a/.github/workflows/test_python_ver_matrix.yml
+++ b/.github/workflows/test_python_ver_matrix.yml
@@ -25,7 +25,7 @@ jobs:
     strategy:
       fail-fast: false
       matrix:
-        python-version: ['3.9', '3.10', '3.11', '3.12']
+        python-version: ['3.10', '3.11', '3.12']
         experimental: [false]
 
     steps:
diff --git a/.github/workflows/test_sbml_semantic_test_suite.yml b/.github/workflows/test_sbml_semantic_test_suite.yml
index 3c0b3bd149..69c78d44b4 100644
--- a/.github/workflows/test_sbml_semantic_test_suite.yml
+++ b/.github/workflows/test_sbml_semantic_test_suite.yml
@@ -29,7 +29,7 @@ jobs:
       matrix:
         cases: ["1-250", "251-500", "501-750", "751-1000",
                 "1000-1250", "1251-"]
-        python-version: [ "3.9" ]
+        python-version: [ "3.11" ]
 
     steps:
     - name: Set up Python ${{ matrix.python-version }}
diff --git a/.github/workflows/test_valgrind.yml b/.github/workflows/test_valgrind.yml
index 034945d461..b3f893647f 100644
--- a/.github/workflows/test_valgrind.yml
+++ b/.github/workflows/test_valgrind.yml
@@ -18,7 +18,7 @@ jobs:
 
     strategy:
       matrix:
-        python-version: [ "3.9" ]
+        python-version: [ "3.11" ]
 
     env:
       ENABLE_AMICI_DEBUGGING: "TRUE"
@@ -57,7 +57,7 @@ jobs:
 
     strategy:
       matrix:
-        python-version: [ "3.9" ]
+        python-version: [ "3.11" ]
 
     env:
       ENABLE_AMICI_DEBUGGING: "TRUE"
diff --git a/.github/workflows/test_windows.yml b/.github/workflows/test_windows.yml
index fbd91ce73a..8b5b3b89f7 100644
--- a/.github/workflows/test_windows.yml
+++ b/.github/workflows/test_windows.yml
@@ -27,7 +27,7 @@ jobs:
 
     strategy:
       matrix:
-        python-version: [ "3.9" ]
+        python-version: [ "3.11" ]
 
     steps:
     - name: Set up Python ${{ matrix.python-version }}
diff --git a/documentation/gfx/amici_workflow.png b/documentation/gfx/amici_workflow.png
index 75f904ff7d..9eab380580 100644
Binary files a/documentation/gfx/amici_workflow.png and b/documentation/gfx/amici_workflow.png differ
diff --git a/documentation/gfx/amici_workflow.svg b/documentation/gfx/amici_workflow.svg
index ee1a86fccc..0d6ea41c64 100644
--- a/documentation/gfx/amici_workflow.svg
+++ b/documentation/gfx/amici_workflow.svg
@@ -7,9 +7,9 @@
    viewBox="0 0 294.54358 107.54766"
    version="1.1"
    id="svg11110"
-   inkscape:version="1.1.1 (1:1.1+202109281946+c3084ef5ed)"
+   inkscape:version="1.2.2 (b0a8486541, 2022-12-01)"
    sodipodi:docname="amici_workflow.svg"
-   inkscape:export-filename="/home/dweindl/src/AMICI-devel/documentation/gfx/amici_workflow.png"
+   inkscape:export-filename="amici_workflow.png"
    inkscape:export-xdpi="90"
    inkscape:export-ydpi="90"
    xmlns:inkscape="http://www.inkscape.org/namespaces/inkscape"
@@ -570,13 +570,13 @@
      inkscape:pageopacity="0.0"
      inkscape:pageshadow="2"
      inkscape:zoom="3.959798"
-     inkscape:cx="83.085046"
-     inkscape:cy="80.180858"
+     inkscape:cx="76.771593"
+     inkscape:cy="80.433396"
      inkscape:document-units="mm"
      inkscape:current-layer="g22231"
      showgrid="false"
      inkscape:window-width="1920"
-     inkscape:window-height="974"
+     inkscape:window-height="1110"
      inkscape:window-x="0"
      inkscape:window-y="0"
      inkscape:window-maximized="1"
@@ -584,7 +584,9 @@
      fit-margin-left="0"
      fit-margin-right="0"
      fit-margin-bottom="0"
-     inkscape:pagecheckerboard="0" />
+     inkscape:pagecheckerboard="0"
+     inkscape:showpageshadow="2"
+     inkscape:deskcolor="#d1d1d1" />
   <metadata
      id="metadata11107">
     <rdf:RDF>
@@ -1498,7 +1500,7 @@
              id="tspan20651"
              x="-16.819941"
              y="40.732136"
-             style="stroke-width:0.264583px">&gt;= 3.9</tspan></text>
+             style="stroke-width:0.264583px">&gt;= 3.10</tspan></text>
       </g>
       <path
          style="fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:0.26499999;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:4;stroke-dasharray:none;stroke-opacity:1;marker-end:url(#marker21180)"
diff --git a/documentation/python_installation.rst b/documentation/python_installation.rst
index dee9bfd4fc..eb7d499227 100644
--- a/documentation/python_installation.rst
+++ b/documentation/python_installation.rst
@@ -8,7 +8,7 @@ Short guide
 
 Installation of the AMICI Python package has the following prerequisites:
 
-* Python>=3.9
+* Python>=3.10
 * :term:`SWIG`>=3.0
 * CBLAS compatible BLAS library
   (e.g., OpenBLAS, CBLAS, Atlas, Accelerate, Intel MKL)
diff --git a/python/sdist/amici/setup.template.py b/python/sdist/amici/setup.template.py
index 599c4df49b..11589564e0 100644
--- a/python/sdist/amici/setup.template.py
+++ b/python/sdist/amici/setup.template.py
@@ -72,7 +72,7 @@ def get_extension() -> CMakeExtension:
     packages=find_namespace_packages(),
     install_requires=["amici==TPL_AMICI_VERSION"],
     extras_require={"wurlitzer": ["wurlitzer"]},
-    python_requires=">=3.9",
+    python_requires=">=3.10",
     package_data={},
     zip_safe=False,
     classifiers=CLASSIFIERS,
diff --git a/python/sdist/setup.cfg b/python/sdist/setup.cfg
index d34d42f98f..7b8f7b32e7 100644
--- a/python/sdist/setup.cfg
+++ b/python/sdist/setup.cfg
@@ -25,14 +25,14 @@ classifiers =
 packages = find_namespace:
 package_dir =
     amici = amici
-python_requires = >=3.9
+python_requires = >=3.10
 install_requires =
     cmake-build-extension==0.5.1
     sympy>=1.9
-    numpy>=1.19.3; python_version=='3.9'
     numpy>=1.21.4; python_version>='3.10'
     numpy>=1.23.2; python_version=='3.11'
-    numpy; python_version>='3.12'
+    numpy>=1.26.2; python_version=='3.12'
+    numpy; python_version>='3.13'
     python-libsbml
     pandas>=2.0.2
     pyarrow