diff --git a/lib/ex_webrtc/peer_connection.ex b/lib/ex_webrtc/peer_connection.ex
index 41364146..c90ac95d 100644
--- a/lib/ex_webrtc/peer_connection.ex
+++ b/lib/ex_webrtc/peer_connection.ex
@@ -9,6 +9,7 @@ defmodule ExWebRTC.PeerConnection do
 
   require Logger
 
+  alias ExWebRTC.RTPCodecParameters
   alias __MODULE__.{Configuration, Demuxer, TWCCRecorder}
 
   alias ExWebRTC.{
@@ -152,9 +153,58 @@ defmodule ExWebRTC.PeerConnection do
     GenServer.call(peer_connection, :get_configuration)
   end
 
+  @doc """
+  Sets the codec that will be used for sending RTP packets.
+
+  `send_rtp/4` overrides some of the RTP packet fields.
+  In particular, when multiple codecs are negotiated, `send_rtp/4` will use
+  payload type of the most preffered by the remote side codec (i.e. the first
+  one from the list of codecs in the remote description).
+
+  Use this function if you want to select, which codec (hence payload type)
+  should be used for sending.
+
+  Although very unlikely, keep in mind that after renegotiation,
+  the selected codec may no longer be supported by the remote side and you might
+  need to call this function again, passing a new codec.
+
+  To check available codecs you can use `get_transceivers/1`:
+
+  ```
+  {:ok, pc} = PeerConnection.start_link()
+  {:ok, rtp_sender} = PeerConnection.add_track(MediaStreamTrack.new(:video))
+
+  tr =
+    pc
+    |> PeerConnection.get_transceivers()
+    |> Enum.find(fn tr -> tr.sender.id == rtp_sender.id end)
+
+  dbg(tr.codecs) # list of supported codecs both for sending and receiving
+
+  # e.g. always prefer h264 over vp8
+  h264 = Enum.find(tr.codecs, fn codec -> codec.mime_type == "video/H264" end)
+  vp8 = Enum.find(tr.codecs, fn codec -> codec.mime_type == "video/VP8" end)
+
+  :ok = PeerConnection.set_sender_codec(pc, rtp_sender.id, h264 || vp8)
+  ```
+  """
+  @spec set_sender_codec(peer_connection(), RTPSender.id(), RTPCodecParameters.t()) ::
+          :ok | {:error, term()}
+  def set_sender_codec(peer_connection, sender_id, codec) do
+    GenServer.call(peer_connection, {:set_sender_codec, sender_id, codec})
+  end
+
   @doc """
   Sends an RTP packet to the remote peer using the track specified by the `track_id`.
 
+  The following fields of the RTP packet will be overwritten by this function:
+  * payload type
+  * ssrc
+  * rtp header extensions
+
+  If you negotiated multiple codecs (hence payload types) and you want to choose,
+  which one should be used, see `set_sender_codec/3`.
+
   Options:
     * `rtx?` - send the packet as if it was retransmitted (use SSRC and payload type specific to RTX)
   """
@@ -576,6 +626,31 @@ defmodule ExWebRTC.PeerConnection do
     {:reply, state.config, state}
   end
 
+  @impl true
+  def handle_call({:set_sender_codec, sender_id, codec}, _from, state) do
+    state.transceivers
+    |> Enum.with_index()
+    |> Enum.find(fn {tr, _idx} -> tr.sender.id == sender_id end)
+    |> case do
+      {tr, idx} when tr.direction in [:sendrecv, :sendonly] ->
+        case RTPTransceiver.set_sender_codec(tr, codec) do
+          {:ok, tr} ->
+            transceivers = List.replace_at(state.transceivers, idx, tr)
+            state = %{state | transceivers: transceivers}
+            {:reply, :ok, state}
+
+          {:error, _reason} = error ->
+            {:reply, error, state}
+        end
+
+      {_tr, _idx} ->
+        {:reply, {:error, :invalid_transceiver_direction}, state}
+
+      nil ->
+        {:reply, {:error, :invalid_sender_id}, state}
+    end
+  end
+
   @impl true
   def handle_call(:get_connection_state, _from, state) do
     {:reply, state.conn_state, state}
diff --git a/lib/ex_webrtc/rtp_sender.ex b/lib/ex_webrtc/rtp_sender.ex
index 61b92531..87427dad 100644
--- a/lib/ex_webrtc/rtp_sender.ex
+++ b/lib/ex_webrtc/rtp_sender.ex
@@ -2,6 +2,7 @@ defmodule ExWebRTC.RTPSender do
   @moduledoc """
   Implementation of the [RTCRtpSender](https://www.w3.org/TR/webrtc/#rtcrtpsender-interface).
   """
+  require Logger
 
   alias ExRTCP.Packet.{TransportFeedback.NACK, PayloadFeedback.PLI}
   alias ExWebRTC.{MediaStreamTrack, RTPCodecParameters, Utils}
@@ -17,6 +18,7 @@ defmodule ExWebRTC.RTPSender do
           id: id(),
           track: MediaStreamTrack.t() | nil,
           codec: RTPCodecParameters.t() | nil,
+          rtx_codec: RTPCodecParameters.t() | nil,
           codecs: [RTPCodecParameters.t()],
           rtp_hdr_exts: %{Extmap.extension_id() => Extmap.t()},
           mid: String.t() | nil,
@@ -93,6 +95,7 @@ defmodule ExWebRTC.RTPSender do
       id: Utils.generate_id(),
       track: track,
       codec: codec,
+      rtx_codec: rtx_codec,
       codecs: codecs,
       rtp_hdr_exts: rtp_hdr_exts,
       pt: pt,
@@ -118,11 +121,32 @@ defmodule ExWebRTC.RTPSender do
   @spec update(sender(), String.t(), [RTPCodecParameters.t()], [Extmap.t()]) :: sender()
   def update(sender, mid, codecs, rtp_hdr_exts) do
     if sender.mid != nil and mid != sender.mid, do: raise(ArgumentError)
-
-    {codec, rtx_codec} = get_default_codec(codecs)
-
     # convert to a map to be able to find extension id using extension uri
     rtp_hdr_exts = Map.new(rtp_hdr_exts, fn extmap -> {extmap.uri, extmap} end)
+
+    # Keep already selected codec if it is still supported.
+    # Otherwise, clear it and wait until user sets it again.
+    codec = if sender.codec in codecs, do: sender.codec, else: nil
+    rtx_codec = codec && find_associated_rtx_codec(codecs, codec)
+
+    if sender.codec != nil and codec == nil do
+      Logger.debug("""
+      Unselecting RTP sender codec as it is no longer supported by the remote side.
+      Call set_sender_codec again passing supported codec.
+      Codec: #{inspect(sender.codec)}
+      Currently negotiated codecs: #{inspect(codecs)}
+      """)
+    end
+
+    if sender.rtx_codec != nil and rtx_codec == nil do
+      Logger.warning("""
+      Unselecting RTX RTP codec as there is no longer RTX codec for selected codec.
+      Retransmissions won't work starting from this moment.
+      Codec: #{inspect(sender.codec)}
+      Currently negotiated codecs: #{inspect(codecs)}
+      """)
+    end
+
     # TODO: handle cases when codec == nil (no valid codecs after negotiation)
     pt = if codec != nil, do: codec.payload_type, else: nil
     rtx_pt = if rtx_codec != nil, do: rtx_codec.payload_type, else: nil
@@ -136,6 +160,7 @@ defmodule ExWebRTC.RTPSender do
       sender
       | mid: mid,
         codec: codec,
+        rtx_codec: rtx_codec,
         codecs: codecs,
         rtp_hdr_exts: rtp_hdr_exts,
         pt: pt,
@@ -221,6 +246,18 @@ defmodule ExWebRTC.RTPSender do
     [fid | ssrc_attrs]
   end
 
+  @doc false
+  @spec set_codec(sender(), RTPCodecParameters.t()) :: {:ok, sender()} | {:error, term()}
+  def set_codec(sender, codec) do
+    if codec in sender.codecs do
+      rtx_codec = find_associated_rtx_codec(sender.codecs, codec)
+      sender = %{sender | codec: codec, rtx_codec: rtx_codec}
+      {:ok, sender}
+    else
+      {:error, :invalid_codec}
+    end
+  end
+
   @doc false
   @spec send_packet(sender(), ExRTP.Packet.t(), boolean()) :: {binary(), sender()}
   def send_packet(sender, packet, rtx?) do
diff --git a/lib/ex_webrtc/rtp_transceiver.ex b/lib/ex_webrtc/rtp_transceiver.ex
index f1effb41..f825b2b7 100644
--- a/lib/ex_webrtc/rtp_transceiver.ex
+++ b/lib/ex_webrtc/rtp_transceiver.ex
@@ -277,6 +277,16 @@ defmodule ExWebRTC.RTPTransceiver do
     %{transceiver | direction: direction}
   end
 
+  @doc false
+  @spec set_sender_codec(transceiver(), RTPCodecParameters.t()) ::
+          {:ok, transceiver()} | {:error, term()}
+  def set_sender_codec(transceiver, codec) do
+    case RTPSender.set_codec(transceiver.sender, codec) do
+      {:ok, sender} -> {:ok, %{transceiver | sender: sender}}
+      {:error, _reason} = error -> error
+    end
+  end
+
   @doc false
   @spec can_add_track?(transceiver(), kind()) :: boolean()
   def can_add_track?(transceiver, kind) do