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GO:0046027 phospholipid:diacylglycerol acyltransferase activity #29862

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sjm41 opened this issue Mar 5, 2025 · 0 comments
Open

GO:0046027 phospholipid:diacylglycerol acyltransferase activity #29862

sjm41 opened this issue Mar 5, 2025 · 0 comments

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@sjm41
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sjm41 commented Mar 5, 2025

id: GO:0046027
name: phospholipid:diacylglycerol acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: phospholipid + 1,2-diacylglycerol = lysophospholipid + triacylglycerol." [EC:2.3.1.158]
synonym: "PDAT activity" RELATED [EC:2.3.1.158]
synonym: "phospholipid:1,2-diacyl-sn-glycerol O-acyltransferase activity" RELATED [EC:2.3.1.158]
xref: EC:2.3.1.158
xref: MetaCyc:2.3.1.158-RXN
xref: RHEA:14057
is_a: GO:0008080 ! N-acetyltransferase activity

EC:2.3.1.158 is:
a glycerophospholipid + a 1,2-diacyl-sn-glycerol = a monoacylglycerophospholipid + a triacyl-sn-glycerol

It is mapped to these two RHEAs:

RHEA:14057: a glycerophospholipid + a 1,2-diacyl-sn-glycerol = a monoacylglycerophospholipid + a triacyl-sn-glycerol (4 annotated proteins)

RHEA:77739: a glycerophospholipid + a 1,2-diacylglycerol = a 1-acyl-sn-glycero-3-phospholipid + a triacylglycerol (0 annotated proteins)

Though those 2 RHEAs are not 'related reactions' in RHEA.
@kaxelsen @aimol Should RHEA have both these entries, and if so, should they be related?

Once I know, I can update the RHEA xrefs and definition in GO as necessary.

Also, GO has this reaction as "is_a: GO:0008080 ! N-acetyltransferase activity"
That can't be right. Probably GO should change this to 'acyltransferase activity, transferring groups other than amino-acyl groups (GO:0016747)' (which corresponds to EC:2.3.1.-)?

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