diff --git a/proto-google-cloud-pubsublite-v1/clirr-ignored-differences.xml b/proto-google-cloud-pubsublite-v1/clirr-ignored-differences.xml
index 5e2cf5d37..a26e5cd5a 100644
--- a/proto-google-cloud-pubsublite-v1/clirr-ignored-differences.xml
+++ b/proto-google-cloud-pubsublite-v1/clirr-ignored-differences.xml
@@ -30,4 +30,66 @@
     <className>com/google/cloud/pubsublite/proto/*OrBuilder</className>
     <method>boolean has*(*)</method>
   </difference>
+
+  <!-- The following 7006 exemptions are related to Protobuf 4.27.4+ runtime upgrade -->
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>com/google/cloud/pubsublite/proto/**</className>
+    <method>* getDefaultInstanceForType()</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>com/google/cloud/pubsublite/proto/**</className>
+    <method>* addRepeatedField(*)</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>com/google/cloud/pubsublite/proto/**</className>
+    <method>* clear()</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>com/google/cloud/pubsublite/proto/**</className>
+    <method>* clearField(*)</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>com/google/cloud/pubsublite/proto/**</className>
+    <method>* clearOneof(*)</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>com/google/cloud/pubsublite/proto/**</className>
+    <method>* clone()</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>com/google/cloud/pubsublite/proto/**</className>
+    <method>* mergeUnknownFields(*)</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>com/google/cloud/pubsublite/proto/**</className>
+    <method>* setField(*)</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>com/google/cloud/pubsublite/proto/**</className>
+    <method>* setRepeatedField(*)</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>com/google/cloud/pubsublite/proto/**</className>
+    <method>* setUnknownFields(*)</method>
+    <to>**</to>
+  </difference>
 </differences>