diff --git a/pint/_typing.py b/pint/_typing.py
index 241459ef1..96bb63ccb 100644
--- a/pint/_typing.py
+++ b/pint/_typing.py
@@ -14,8 +14,10 @@
 
 
 HAS_NUMPY = False
+HAS_AUTOUNCERTAINTIES = False
+
 if TYPE_CHECKING:
-    from .compat import HAS_NUMPY
+    from .compat import HAS_NUMPY, HAS_AUTOUNCERTAINTIES
 
 if HAS_NUMPY:
     from .compat import np
@@ -26,8 +28,12 @@
     Scalar: TypeAlias = Union[float, int, Decimal, Fraction]
     Array: TypeAlias = Never
 
+if HAS_AUTOUNCERTAINTIES:
+    from auto_uncertainties import Uncertainty
+else:
+    Uncertainty: TypeAlias = Never
 # TODO: Change when Python 3.10 becomes minimal version.
-Magnitude = Union[Scalar, Array]
+Magnitude = Union[Scalar, Array, Uncertainty]
 
 UnitLike = Union[str, dict[str, Scalar], "UnitsContainer", "Unit"]
 
diff --git a/pint/compat.py b/pint/compat.py
index 4b4cbab92..a564abfff 100644
--- a/pint/compat.py
+++ b/pint/compat.py
@@ -171,6 +171,18 @@ def _to_magnitude(value, force_ndarray=False, force_ndarray_like=False):
         return value
 
 
+
+try:
+    from auto_uncertainties import Uncertainty
+except ImportError:
+    HAS_AUTOUNCERTAINTIES = False
+
+    class Uncertainty(object):
+        ...
+
+else:
+    HAS_AUTOUNCERTAINTIES = True
+
 try:
     from babel import Locale
     from babel import units as babel_units
diff --git a/pint/facets/__init__.py b/pint/facets/__init__.py
index 12729289c..74e56c5b2 100644
--- a/pint/facets/__init__.py
+++ b/pint/facets/__init__.py
@@ -77,9 +77,11 @@ class that belongs to a registry that has NumpyRegistry as one of its bases.
     GenericNonMultiplicativeRegistry,
     NonMultiplicativeRegistry,
 )
+
 from .numpy import GenericNumpyRegistry, NumpyRegistry
 from .plain import GenericPlainRegistry, MagnitudeT, PlainRegistry, QuantityT, UnitT
 from .system import GenericSystemRegistry, SystemRegistry
+from .uncertainties import UncertaintyRegistry, GenericUncertaintyRegistry
 
 __all__ = [
     "ContextRegistry",
@@ -103,4 +105,6 @@ class that belongs to a registry that has NumpyRegistry as one of its bases.
     "QuantityT",
     "UnitT",
     "MagnitudeT",
+    "UncertaintyRegistry",
+    "GenericUncertaintyRegistry",
 ]
diff --git a/pint/facets/uncertainties/__init__.py b/pint/facets/uncertainties/__init__.py
new file mode 100644
index 000000000..c8c1968ce
--- /dev/null
+++ b/pint/facets/uncertainties/__init__.py
@@ -0,0 +1,67 @@
+"""
+    pint.facets.Uncertainty
+    ~~~~~~~~~~~~~~~~
+
+    Adds pint the capability to interoperate with Uncertainty
+
+    :copyright: 2022 by Pint Authors, see AUTHORS for more details.
+    :license: BSD, see LICENSE for more details.
+"""
+
+
+from __future__ import annotations
+
+from typing import Generic, Any
+
+from ...compat import TypeAlias, Uncertainty
+from ..plain import (
+    GenericPlainRegistry,
+    PlainQuantity,
+    QuantityT,
+    UnitT,
+    PlainUnit,
+    MagnitudeT,
+)
+
+
+class UncertaintyQuantity(Generic[MagnitudeT], PlainQuantity[MagnitudeT]):
+    @property
+    def value(self):
+        if isinstance(self._magnitude, Uncertainty):
+            return self._magnitude.value * self.units
+        else:
+            return self._magnitude * self.units
+
+    @property
+    def error(self):
+        if isinstance(self._magnitude, Uncertainty):
+            return self._magnitude.error * self.units
+        else:
+            return (0 * self._magnitude) * self.units
+
+    def plus_minus(self, err):
+        from auto_uncertainties import nominal_values, std_devs
+
+        my_value = nominal_values(self._magnitude) * self.units
+        my_err = std_devs(self._magnitude) * self.units
+
+        new_err = (my_err**2 + err**2) ** 0.5
+
+        return Uncertainty.from_quantities(my_value, new_err)
+
+
+class UncertaintyUnit(PlainUnit):
+    pass
+
+
+class GenericUncertaintyRegistry(
+    Generic[QuantityT, UnitT], GenericPlainRegistry[QuantityT, UnitT]
+):
+    pass
+
+
+class UncertaintyRegistry(
+    GenericUncertaintyRegistry[UncertaintyQuantity[Any], UncertaintyUnit]
+):
+    Quantity: TypeAlias = UncertaintyQuantity[Any]
+    Unit: TypeAlias = UncertaintyUnit
diff --git a/pint/pint_eval.py b/pint/pint_eval.py
index c2ddb29cd..a2008df9b 100644
--- a/pint/pint_eval.py
+++ b/pint/pint_eval.py
@@ -26,8 +26,13 @@
 
 from .errors import DefinitionSyntaxError
 
+try:
+    from auto_uncertainties import Uncertainty
+except ImportError:
+    Uncertainty = None
 # For controlling order of operations
 _OP_PRIORITY = {
+    "±": 4,
     "+/-": 4,
     "**": 3,
     "^": 3,
@@ -42,12 +47,19 @@
 }
 
 
+
+def _uncertainty(left: float, right: float) -> Uncertainty:
+    if Uncertainty is None:
+        raise ImportError("auto_uncertainties is required for uncertainty calculations")
+    return Uncertainty.from_quantities(left, right)
+
 def _ufloat(left, right):
     if HAS_UNCERTAINTIES:
         return ufloat(left, right)
     raise TypeError("Could not import support for uncertainties")
 
 
+
 def _power(left: Any, right: Any) -> Any:
     from . import Quantity
     from .compat import is_duck_array
@@ -295,7 +307,8 @@ def _finalize_e(nominal_value, std_dev, toklist, possible_e):
 _UNARY_OPERATOR_MAP: dict[str, UnaryOpT] = {"+": lambda x: x, "-": lambda x: x * -1}
 
 _BINARY_OPERATOR_MAP: dict[str, BinaryOpT] = {
-    "+/-": _ufloat,
+    "±": _uncertainty,
+    "+/-": _uncertainty,
     "**": _power,
     "*": operator.mul,
     "": operator.mul,  # operator for implicit ops
@@ -438,7 +451,7 @@ def _build_eval_tree(
         token_type = current_token.type
         token_text = current_token.string
 
-        if token_type == tokenlib.OP:
+        if token_type == tokenlib.OP or token_text == "±":
             if token_text == ")":
                 if prev_op == "<none>":
                     raise DefinitionSyntaxError(
@@ -465,6 +478,7 @@ def _build_eval_tree(
                 else:
                     # get first token
                     result = right
+            # This means it's an operator in op_priority
             elif token_text in op_priority:
                 if result:
                     # equal-priority operators are grouped in a left-to-right order,
diff --git a/pint/registry.py b/pint/registry.py
index ceb9b62d1..8e13cbba5 100644
--- a/pint/registry.py
+++ b/pint/registry.py
@@ -28,6 +28,7 @@
 class Quantity(
     facets.SystemRegistry.Quantity,
     facets.ContextRegistry.Quantity,
+    facets.UncertaintyRegistry.Quantity,
     facets.DaskRegistry.Quantity,
     facets.NumpyRegistry.Quantity,
     facets.MeasurementRegistry.Quantity,
@@ -40,6 +41,7 @@ class Quantity(
 class Unit(
     facets.SystemRegistry.Unit,
     facets.ContextRegistry.Unit,
+    facets.UncertaintyRegistry.Unit,
     facets.DaskRegistry.Unit,
     facets.NumpyRegistry.Unit,
     facets.MeasurementRegistry.Unit,
@@ -53,6 +55,7 @@ class GenericUnitRegistry(
     Generic[facets.QuantityT, facets.UnitT],
     facets.GenericSystemRegistry[facets.QuantityT, facets.UnitT],
     facets.GenericContextRegistry[facets.QuantityT, facets.UnitT],
+    facets.GenericUncertaintyRegistry[facets.QuantityT, facets.UnitT],
     facets.GenericDaskRegistry[facets.QuantityT, facets.UnitT],
     facets.GenericNumpyRegistry[facets.QuantityT, facets.UnitT],
     facets.GenericMeasurementRegistry[facets.QuantityT, facets.UnitT],
diff --git a/pint/testsuite/helpers.py b/pint/testsuite/helpers.py
index d317e0755..72a5d4592 100644
--- a/pint/testsuite/helpers.py
+++ b/pint/testsuite/helpers.py
@@ -17,6 +17,7 @@
     HAS_NUMPY,
     HAS_NUMPY_ARRAY_FUNCTION,
     HAS_UNCERTAINTIES,
+    HAS_AUTOUNCERTAINTIES,
     NUMPY_VER,
 )
 
@@ -151,6 +152,10 @@ def requires_babel(tested_locales=[]):
 requires_not_babel = pytest.mark.skipif(
     HAS_BABEL, reason="Requires Babel not to be installed"
 )
+requires_autouncertainties = pytest.mark.skipif(
+    not HAS_AUTOUNCERTAINTIES, reason="Requires Auto-Uncertainties"
+)
+
 requires_uncertainties = pytest.mark.skipif(
     not HAS_UNCERTAINTIES, reason="Requires Uncertainties"
 )
diff --git a/pint/testsuite/test_pint_eval.py b/pint/testsuite/test_pint_eval.py
index 3cee7d758..73dc35baa 100644
--- a/pint/testsuite/test_pint_eval.py
+++ b/pint/testsuite/test_pint_eval.py
@@ -142,6 +142,12 @@ def test_build_eval_tree(self, input_text, parsed):
             ("3 kg + 5", "((3 * kg) + 5)"),
             ("(5 % 2) m", "((5 % 2) * m)"),  # mod operator
             ("(5 // 2) m", "((5 // 2) * m)"),  # floordiv operator
+            # Uncertainties
+            ("3 +/- 5", "(3 ± 5)"),
+            ("3 ± 5", "(3 ± 5)"),
+            ("3 +- 5", "(3 ± 5)"),
+            ("2 * (3 +- 5)", "(2 * (3 ± 5))"),
+            ("(3 +- 5)^2", "((3 ± 5) ** 2)"),
         ),
     )
     def test_preprocessed_eval_tree(self, input_text, parsed):
diff --git a/pint/testsuite/test_uncertainty.py b/pint/testsuite/test_uncertainty.py
new file mode 100644
index 000000000..de7da701a
--- /dev/null
+++ b/pint/testsuite/test_uncertainty.py
@@ -0,0 +1,68 @@
+import pytest
+
+from pint import DimensionalityError
+from pint.testsuite import QuantityTestCase, helpers
+
+from pint.compat import Uncertainty
+
+
+# TODO: do not subclass from QuantityTestCase
+@helpers.requires_autouncertainties()
+class TestQuantity(QuantityTestCase):
+    def test_simple(self):
+        Q = self.ureg.Quantity
+        Q(Uncertainty(4.0, 0.1), "s")
+
+    def test_build(self):
+        Q = self.ureg.Quantity
+        v, u, w = self.Q_(4.0, "s"), self.Q_(0.1, "s"), self.Q_(0.1, "days")
+        Q(Uncertainty(v.magnitude, u.magnitude), "s")
+        (
+            Q(Uncertainty(v.magnitude, u.magnitude), "s"),
+            Q(Uncertainty.from_quantities(v, u)),
+            v.plus_minus(u),
+            v.plus_minus(w),
+        )
+
+    def test_raise_build(self):
+        v, u = self.Q_(1.0, "s"), self.Q_(0.1, "s")
+        o = self.Q_(0.1, "m")
+
+        with pytest.raises(DimensionalityError):
+            Uncertainty.from_quantities(v, u._magnitude)
+        with pytest.raises(DimensionalityError):
+            Uncertainty.from_quantities(v._magnitude, u)
+        with pytest.raises(DimensionalityError):
+            Uncertainty.from_quantities(v, o)
+        with pytest.raises(DimensionalityError):
+            v.plus_minus(o)
+        with pytest.raises(DimensionalityError):
+            v.plus_minus(u._magnitude)
+
+    def test_propagate_linear(self):
+        v = [0, 1, 2, 3, 4]
+        e = [1, 2, 3, 4, 5]
+
+        x_without_units = [Uncertainty(vi, ei) for vi, ei in zip(v, e)]
+        x_with_units = [self.Q_(u, "s") for u in x_without_units]
+
+        for x_nou, x_u in zip(x_without_units, x_with_units):
+            for y_nou, y_u in zip(x_without_units, x_with_units):
+                z_nou = x_nou + y_nou
+                z_u = x_u + y_u
+                assert z_nou.value == z_u.value.m
+                assert z_nou.error == z_u.error.m
+
+    def test_propagate_product(self):
+        v = [1, 2, 3, 4]
+        e = [1, 2, 3, 4, 5]
+
+        x_without_units = [Uncertainty(vi, ei) for vi, ei in zip(v, e)]
+        x_with_units = [self.Q_(u, "s") for u in x_without_units]
+
+        for x_nou, x_u in zip(x_without_units, x_with_units):
+            for y_nou, y_u in zip(x_without_units, x_with_units):
+                z_nou = x_nou * y_nou
+                z_u = x_u * y_u
+                assert z_nou.value == z_u.value.m
+                assert z_nou.error == z_u.error.m
diff --git a/pint/util.py b/pint/util.py
index c7a7ec10c..375afa300 100644
--- a/pint/util.py
+++ b/pint/util.py
@@ -938,6 +938,10 @@ def string_preprocessor(input_string: str) -> str:
 
     # Handle caret exponentiation
     input_string = input_string.replace("^", "**")
+
+    # Handle uncertainties
+    input_string = input_string.replace("+/-", "±")
+    input_string = input_string.replace("+-", "±")
     return input_string
 
 
diff --git a/pyproject.toml b/pyproject.toml
index 9f29f8f92..60e8bdf24 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -64,6 +64,7 @@ pandas = ["pint-pandas >= 0.3"]
 xarray = ["xarray"]
 dask = ["dask"]
 mip = ["mip >= 1.13"]
+auto_uncertainties = ["auto-uncertainties @ git+https://github.com/varchasgopalaswamy/AutoUncertainties.git"]
 
 [project.urls]
 Homepage = "https://github.com/hgrecco/pint"