diff --git a/components/form/FormItemLabel.tsx b/components/form/FormItemLabel.tsx
index bfcf1d9d07fb..c57ead79c7cd 100644
--- a/components/form/FormItemLabel.tsx
+++ b/components/form/FormItemLabel.tsx
@@ -93,9 +93,18 @@ const FormItemLabel: React.FC<FormItemLabelProps & { required?: boolean; prefixC
         const tooltipProps = toTooltipProps(tooltip);
         if (tooltipProps) {
           const { icon = <QuestionCircleOutlined />, ...restTooltipProps } = tooltipProps;
-          const tooltipNode = (
+          const tooltipNode: React.ReactNode = (
             <Tooltip {...restTooltipProps}>
-              {React.cloneElement(icon, { className: `${prefixCls}-item-tooltip`, title: '' })}
+              {React.cloneElement(icon, {
+                className: `${prefixCls}-item-tooltip`,
+                title: '',
+                onClick: (e: React.MouseEvent) => {
+                  // Prevent label behavior in tooltip icon
+                  // https://github.com/ant-design/ant-design/issues/46154
+                  e.preventDefault();
+                },
+                tabIndex: null,
+              })}
             </Tooltip>
           );
 
diff --git a/components/form/__tests__/index.test.tsx b/components/form/__tests__/index.test.tsx
index a70229ed1d26..6987883acbeb 100644
--- a/components/form/__tests__/index.test.tsx
+++ b/components/form/__tests__/index.test.tsx
@@ -1252,6 +1252,21 @@ describe('Form', () => {
 
       expect(container.querySelector('.ant-tooltip-inner')).toHaveTextContent('Bamboo');
     });
+
+    // https://github.com/ant-design/ant-design/issues/46154
+    it('should not trigger form change when click icon', async () => {
+      const onChange = jest.fn();
+
+      const { container } = render(
+        <Form>
+          <Form.Item label="light" name="foo" tooltip={{ title: 'Bar' }}>
+            <Switch onChange={onChange} />
+          </Form.Item>
+        </Form>,
+      );
+      fireEvent.click(container.querySelector('.anticon-question-circle')!);
+      expect(onChange).not.toHaveBeenCalled();
+    });
   });
 
   it('warningOnly validate', async () => {