diff --git a/pkg/daemon/gateway.go b/pkg/daemon/gateway.go
index a64146a8bf9..142bf61e679 100644
--- a/pkg/daemon/gateway.go
+++ b/pkg/daemon/gateway.go
@@ -101,7 +101,7 @@ func (c *Controller) getSubnetsNeedNAT(protocol string) ([]string, error) {
 	for _, subnet := range subnets {
 		if c.isSubnetNeedNat(subnet, protocol) {
 			cidrBlock, err := getCidrByProtocol(subnet.Spec.CIDRBlock, protocol)
-			if err == nil {
+			if err == nil && cidrBlock != "" {
 				subnetsNeedNat = append(subnetsNeedNat, cidrBlock)
 			}
 		}
@@ -141,7 +141,7 @@ func (c *Controller) getSubnetsDistributedGateway(protocol string) ([]string, er
 			subnet.Spec.GatewayType == kubeovnv1.GWDistributedType &&
 			(subnet.Spec.Protocol == kubeovnv1.ProtocolDual || subnet.Spec.Protocol == protocol) {
 			cidrBlock, err := getCidrByProtocol(subnet.Spec.CIDRBlock, protocol)
-			if err == nil {
+			if err == nil && cidrBlock != "" {
 				result = append(result, cidrBlock)
 			}
 		}
@@ -172,7 +172,7 @@ func (c *Controller) getDefaultVpcSubnetsCIDR(protocol string) ([]string, map[st
 	for _, subnet := range subnets {
 		if subnet.Spec.Vpc == c.config.ClusterRouter && (subnet.Spec.Vlan == "" || subnet.Spec.LogicalGateway) && subnet.Spec.CIDRBlock != "" {
 			cidrBlock, err := getCidrByProtocol(subnet.Spec.CIDRBlock, protocol)
-			if err == nil {
+			if err == nil && cidrBlock != "" {
 				ret = append(ret, cidrBlock)
 				subnetMap[subnet.Name] = cidrBlock
 			}
@@ -204,22 +204,17 @@ func (c *Controller) getOtherNodes(protocol string) ([]string, error) {
 }
 
 func getCidrByProtocol(cidr, protocol string) (string, error) {
-	var cidrStr string
 	if err := util.CheckCidrs(cidr); err != nil {
 		return "", err
 	}
 
-	if util.CheckProtocol(cidr) == kubeovnv1.ProtocolDual {
-		cidrBlocks := strings.Split(cidr, ",")
-		if protocol == kubeovnv1.ProtocolIPv4 {
-			cidrStr = cidrBlocks[0]
-		} else if protocol == kubeovnv1.ProtocolIPv6 {
-			cidrStr = cidrBlocks[1]
+	for _, cidr := range strings.Split(cidr, ",") {
+		if util.CheckProtocol(cidr) == protocol {
+			return cidr, nil
 		}
-	} else {
-		cidrStr = cidr
 	}
-	return cidrStr, nil
+
+	return "", nil
 }
 
 func (c *Controller) getEgressNatIPByNode(nodeName string) (map[string]string, error) {
diff --git a/pkg/daemon/gateway_linux.go b/pkg/daemon/gateway_linux.go
index ddefc4b8fd3..a36286cb86d 100644
--- a/pkg/daemon/gateway_linux.go
+++ b/pkg/daemon/gateway_linux.go
@@ -205,7 +205,7 @@ func (c *Controller) reconcileNatOutGoingPolicyIPset(protocol string) {
 		return
 	}
 
-	subnetCidrs := make([]string, 0)
+	subnetCidrs := make([]string, 0, len(subnets))
 	natPolicyRuleIDs := strset.New()
 	for _, subnet := range subnets {
 		cidrBlock, err := getCidrByProtocol(subnet.Spec.CIDRBlock, protocol)
@@ -213,7 +213,9 @@ func (c *Controller) reconcileNatOutGoingPolicyIPset(protocol string) {
 			klog.Errorf("failed to get subnet %s CIDR block by protocol: %v", subnet.Name, err)
 			continue
 		}
-		subnetCidrs = append(subnetCidrs, cidrBlock)
+		if cidrBlock != "" {
+			subnetCidrs = append(subnetCidrs, cidrBlock)
+		}
 		for _, rule := range subnet.Status.NatOutgoingPolicyRules {
 			if rule.RuleID == "" {
 				klog.Errorf("unexpected empty ID for NAT outgoing rule %q of subnet %s", rule.NatOutgoingPolicyRule, subnet.Name)
@@ -1003,6 +1005,9 @@ func (c *Controller) generateNatOutgoingPolicyChainRules(protocol string) ([]uti
 			klog.Errorf("failed to get subnet %s cidr block with protocol: %v", subnet.Name, err)
 			continue
 		}
+		if cidrBlock == "" {
+			continue
+		}
 
 		ovnNatPolicySubnetChainName := OvnNatOutGoingPolicySubnet + util.GetTruncatedUID(string(subnet.GetUID()))
 		natPolicySubnetIptables = append(natPolicySubnetIptables, util.IPTableRule{Table: NAT, Chain: OvnNatOutGoingPolicy, Rule: strings.Fields(fmt.Sprintf(`-s %s -m comment --comment natPolicySubnet-%s -j %s`, cidrBlock, subnet.Name, ovnNatPolicySubnetChainName))})
@@ -1616,7 +1621,7 @@ func (c *Controller) getSubnetsNeedPR(protocol string) (map[policyRouteMeta]stri
 			}
 			if meta.gateway != "" {
 				cidrBlock, err := getCidrByProtocol(subnet.Spec.CIDRBlock, protocol)
-				if err == nil {
+				if err == nil && cidrBlock != "" {
 					subnetsNeedPR[meta] = cidrBlock
 				}
 			}
diff --git a/pkg/daemon/gateway_test.go b/pkg/daemon/gateway_test.go
new file mode 100644
index 00000000000..ce44d43650c
--- /dev/null
+++ b/pkg/daemon/gateway_test.go
@@ -0,0 +1,61 @@
+package daemon
+
+import (
+	"testing"
+
+	"github.com/stretchr/testify/require"
+
+	kubeovnv1 "github.com/kubeovn/kube-ovn/pkg/apis/kubeovn/v1"
+)
+
+func TestGetCidrByProtocol(t *testing.T) {
+	cases := []struct {
+		name     string
+		cidr     string
+		protocol string
+		wantErr  bool
+		expetced string
+	}{{
+		name:     "ipv4 only",
+		cidr:     "1.1.1.0/24",
+		protocol: kubeovnv1.ProtocolIPv4,
+		expetced: "1.1.1.0/24",
+	}, {
+		name:     "ipv6 only",
+		cidr:     "2001:db8::/120",
+		protocol: kubeovnv1.ProtocolIPv6,
+		expetced: "2001:db8::/120",
+	}, {
+		name:     "get ipv4 from ipv6",
+		cidr:     "2001:db8::/120",
+		protocol: kubeovnv1.ProtocolIPv4,
+	}, {
+		name:     "get ipv4 from dual stack",
+		cidr:     "1.1.1.0/24,2001:db8::/120",
+		protocol: kubeovnv1.ProtocolIPv4,
+		expetced: "1.1.1.0/24",
+	}, {
+		name:     "get ipv6 from ipv4",
+		cidr:     "1.1.1.0/24",
+		protocol: kubeovnv1.ProtocolIPv6,
+	}, {
+		name:     "get ipv6 from dual stack",
+		cidr:     "1.1.1.0/24,2001:db8::/120",
+		protocol: kubeovnv1.ProtocolIPv6,
+		expetced: "2001:db8::/120",
+	}, {
+		name:     "invalid cidr",
+		cidr:     "foo bar",
+		protocol: kubeovnv1.ProtocolIPv4,
+		wantErr:  true,
+	}}
+	for _, c := range cases {
+		t.Run(c.name, func(t *testing.T) {
+			got, err := getCidrByProtocol(c.cidr, c.protocol)
+			if (err != nil) != c.wantErr {
+				t.Errorf("getCidrByProtocol(%q, %q) error = %v, wantErr = %v", c.cidr, c.protocol, err, c.wantErr)
+			}
+			require.Equal(t, c.expetced, got)
+		})
+	}
+}