diff --git a/CMakeLists.txt b/CMakeLists.txt
index b830e513cb2b3..92f12e2868912 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -3800,7 +3800,9 @@ endif()
 
 if(gRPC_BUILD_CODEGEN)
 
-if(gRPC_INSTALL)
+# grpcpp_channelz doesn't build with protobuf-lite, so no install required
+# See https://github.com/grpc/grpc/issues/22826
+if(gRPC_INSTALL AND NOT gRPC_USE_PROTO_LITE)
   install(TARGETS grpcpp_channelz EXPORT gRPCTargets
     RUNTIME DESTINATION ${gRPC_INSTALL_BINDIR}
     LIBRARY DESTINATION ${gRPC_INSTALL_LIBDIR}
diff --git a/templates/CMakeLists.txt.template b/templates/CMakeLists.txt.template
index 40cf7ff615d8c..cef2534cbd126 100644
--- a/templates/CMakeLists.txt.template
+++ b/templates/CMakeLists.txt.template
@@ -685,7 +685,13 @@
   </%def>
 
   <%def name="cc_install(tgt)">
+  % if tgt.name == 'grpcpp_channelz':
+  # grpcpp_channelz doesn't build with protobuf-lite, so no install required
+  # See https://github.com/grpc/grpc/issues/22826
+  if(gRPC_INSTALL AND NOT gRPC_USE_PROTO_LITE)
+  % else:
   if(gRPC_INSTALL)
+  % endif
     install(TARGETS ${tgt.name} EXPORT gRPCTargets
       RUNTIME DESTINATION <%text>${gRPC_INSTALL_BINDIR}</%text>
       LIBRARY DESTINATION <%text>${gRPC_INSTALL_LIBDIR}</%text>