HLA-DRB1_01_03.txt

HLA_Allele	Significance test	Clinical Relevance	Method	Experimental methods	Reference	Algeria_Oran_(n=100)	Algeria_pop_2_(n=106)	Argentina_Buenos_Aires_(n=466)	Argentina_Gran_Chaco_Eastern_Toba_(n=135)	Argentina_Gran_Chaco_Mataco_Wichi_(n=49)	Argentina_Gran_Chaco_Western_Toba_Pilaga_(n=19)	Argentina_Rosario_Toba_(n=86)	Australia_Cape_York_Peninsula_Aborigine_(n=103)	Azores_Central_Islands_(n=59)	Azores_Oriental_Islands_(n=43)	Azores_Terceira_Island_(n=130)	Belgium_(n=99)	Brazil_Paraná_Caucasian_(n=641)	Brazil_Puyanawa_(n=150)	Brazil_Barra_Mansa_Rio_State_Black_(n=73)	Brazil_Barra_Mansa_Rio_State_Caucasian_(n=405)	Brazil_Central_Plateau_Xavante_(n=74)	Brazil_East_Amazon_(n=41)	Brazil_Guarani_M_bya_(n=93)	Brazil_Guarani_Nandeva_(n=86)	Brazil_Kaingang_(n=235)	Brazil_Mato_Grosso_do_Sul_(n=203)	Brazil_Mixed_(n=108)	Brazil_North_East_Mixed_(n=205)	Brazil_Rio_de_Janeiro_Black_(n=68)	Brazil_Rio_de_Janeiro_Caucasian_(n=521)	Brazil_Rio_de_Janeiro_Parda_(n=170)	Brazil_South_Caucasian_(n=73)	Brazil_Southeast_Caucasian_(n=103)	Brazil_Southeast_Mixed_Race_(n=42)	Bulgaria_(n=55)	Canada_British_Columbia_Athabaskan_(n=62)	Canada_British_Columbia_Penutian_(n=26)	Cape_Verde_Northwestern_Islands_(n=62)	Cape_Verde_Southeastern_Islands_(n=62)	Central_African_Republic_Aka_Pygmy_(n=93)	Chile_Santiago_(n=920)	China_Beijing_Shijiazhuang_Tianjian_Han_(n=618)	China_Urumqi_Uyghur_(n=57)	Colombia_Barranquilla_(n=188)	Colombia_Bogotá_Cord_Blood_(n=1463)	Colombia_Providencia_Island_African_(n=30)	Colombia_Wayu_from_Guajira_Peninsula_(n=48)	Congo_Kinshasa_Bantu_(n=90)	Cook_Islands_Rarotonga_(n=78)	Costa_Rica_African_-Caribbean_(G)_(n=102)	Costa_Rica_Central_Valley_Mestizo_(G)_(n=221)	Croatia_pop_4_(n=4000)	Czech_Republic_(n=106)	Czech_Republic_NMDR_(n=5099)	Czech_Republic_pop_2_(n=99)	Czech_Republic_Romani_(n=34)	Denmark_(n=55)	Ecuador_Amazonia_Mixed_Ancestry_(n=39)	Ecuador_Andes_Mixed_Ancestry_(n=824)	Ecuador_Coast_Mixed_Ancestry_(n=238)	Ecuador_Mixed_Ancestry_(n=1173)	England_Bedfordshire_(n=354)	England_North_West_(n=298)	England_pop_6_(n=177)	Ethiopia_Amhara_(n=98)	Ethiopia_Oromo_(n=83)	Fiji_Viti_Levu_Island_(n=57)	Finland_pop2_(n=150)	France_French_Bone_Marrow_Donor_Registry_(n=42623)	France_Rennes_(n=200)	France_Rennes_pop_3_(n=200)	France_Southeast_(n=130)	France_West_(n=100)	Germany_DKMS_-_Austria_minority_(n=1698)	Germany_DKMS_-_Bosnia_and_Herzegovina_minority_(n=1028)	Germany_DKMS_-_Croatia_minority_(n=2057)	Germany_DKMS_-_France_minority_(n=1406)	Germany_DKMS_-_German_donors_(n=3456066)	Germany_DKMS_-_Greece_minority_(n=1894)	Germany_DKMS_-_Italy_minority_(n=1159)	Germany_DKMS_-_Netherlands_minority_(n=1374)	Germany_DKMS_-_Portugal_minority_(n=1176)	Germany_DKMS_-_Romania_minority_(n=1234)	Germany_DKMS_-_Spain_minority_(n=1107)	Germany_DKMS_-_United_Kingdom_minority_(n=1043)	Germany_Essen_(n=174)	Germany_pop_6_(n=8862)	Germany_pop_8_(n=39689)	Greece_pop_4_(n=98)	Guinea_Bissau_(n=65)	Hong_Kong_Chinese_BMDR_(n=7595)	India_Northeast_Kayastha_(n=190)	India_Northeast_Lachung_(n=58)	India_Northeast_Mathur_(n=155)	India_Northeast_Mech_(n=63)	India_Northeast_Rajbanshi_(n=98)	India_Northeast_Rastogi_(n=196)	India_Northeast_Shia_(n=190)	India_Northeast_Sunni_(n=188)	India_Northeast_Vaish_(n=198)	India_Uttar_Pradesh_(n=202)	Indonesia_Java_Yogyakarta_Region_(n=62)	Indonesia_Moluccan_Islands_(n=24)	Indonesia_Nusa_Tenggara_Islands_(n=49)
DRB1*01:03		Significantly associated with VACV-induced cytokine	Experimentally proven	Neutralizing Antibody Assay, IFN-γ Elispot, Cytokine Measurements, HLA Genotyping	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127812/	0.02		0.012	0.008	0	0	0.023	0.005	0.036	0.013	0.008	0.005	0.012	0.007			0	0	0	0.012	0	0.002	0.005	0.004				0.0069	0.01	0	0	0	0	0	0.008	0	0.00826	0.001	0	0.011	0.0082	0.033	0.021	0	0.006	0.005	0.011	0.0016	0.005	0.00177			0	0	0.00425	0.0063	0.00426		0.018	0.025	0.005	0	0	0.003	0.0072	0.013	0.01	0.004		0.00177	0.00243	0.00191	0.00569	0.00311	0.00106	0.00086	0.00437	0.00638	0.00122	0.011	0.012	0.003	0.0032	0.00399	0	0	0.00013	0	0	0	0	0	0	0.018	0	0	0.01	0	0	0
DRB1*01:03:01																				0.0068	0.00988									0.015	0.0058	0.0089																																																																									
Total Frequency						0.02	0	0.012	0.008	0	0	0.023	0.005	0.036	0.013	0.008	0.005	0.012	0.007	0.007	0.01	0	0	0	0.012	0	0.002	0.005	0.004	0.015	0.006	0.009	0.007	0.01	0	0	0	0	0	0.008	0	0.008	0.001	0	0.011	0.008	0.033	0.021	0	0.006	0.005	0.011	0.002	0.005	0.002	0	0	0	0	0.004	0.006	0.004	0	0.018	0.025	0.005	0	0	0.003	0.007	0.013	0.01	0.004	0	0.002	0.002	0.002	0.006	0.003	0.001	0.001	0.004	0.006	0.001	0.011	0.012	0.003	0.003	0.004	0	0	0	0	0	0	0	0	0	0.018	0	0	0.01	0	0	0