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Vaccinia HLA Associations

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Compilation of human leukocyte antigen (HLA) alleles associated with immune responses to Small pox vaccines

This repository aims to provide a open source compilation of human leukocyte antigen (HLA) alleles that have been previously reported to be associated with immune responses elicited by Small pox vaccines.
The HLA alleles were manually curated from available literature sources and were systematically compiled in a pre-formatted template.
For extensive understanding on the prvealence of these alleles in various global populations, global allele frequencies were retrived from Allele Frequency Net Database (http://www.allelefrequencies.net/default.asp) and documented.

HLA compilation summary

Summary of HLA alleles with significant associations with Smallpox vaccine immune responses - HLA-A - 1
- HLA-B - 11
- HLA-DQB1 - 2
- HLA-DRB1 - 4

Reference articles

1. Ovsyannikova IG, Vierkant RA, Pankratz VS, Jacobson RM, Poland GA. Human leukocyte antigen genotypes in the genetic control of adaptive immune responses to smallpox vaccine. J Infect Dis. 2011 Jun 1;203(11):1546-55. doi: 10.1093/infdis/jir167. PMID: 21592983; PMCID: PMC3096794.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096794/
2. Ovsyannikova IG, Pankratz VS, Salk HM, Kennedy RB, Poland GA. HLA alleles associated with the adaptive immune response to smallpox vaccine: a replication study. Hum Genet. 2014 Sep;133(9):1083-92. doi: 10.1007/s00439-014-1449-x. Epub 2014 Jun 1. PMID: 24880604; PMCID: PMC4127812.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127812/
3. DREXLER, I., STAIB, C., KASTENMÜLLER, W., STEVANOVIĆ, S., SCHMIDT, B., LEMONNIER, F. A., RAMMENSEE, H., BUSCH, D. H., BERNHARD, H., ERFLE, V. AND SUTTER, G.Identification of vaccinia virus epitope-specific HLA-A*0201-restricted T cells and comparative analysis of smallpox vaccineshttps://www.pnas.org/doi/abs/10.1073/pnas.262668999
4. Jun Ando, Minhtran C. Ngo, Miki Ando, Ann Leen, Cliona M. Rooney,Identification of protective T-cell antigens for smallpox vaccines,Cytotherapy,Volume 22, Issue 11,2020,Pages 642-652,ISSN 1465-3249https://www.sciencedirect.com/science/article/abs/pii/S1465324920306551?via%3Dihub