diff --git a/src/python/setup.py.in b/src/python/setup.py.in
index 6df075952..be88c21a6 100644
--- a/src/python/setup.py.in
+++ b/src/python/setup.py.in
@@ -26,7 +26,7 @@ package_name = '@TARGET_NAME@'
 def _onnxruntime_dependency() -> str:
     dependency = None
     # Use stable version as default
-    ort_version = os.environ.get("ONNXRUNTIME_VERSION", "1.20.0")
+    ort_version = os.environ.get("ONNXRUNTIME_VERSION", "1.20.1")
 
     if package_name == "onnxruntime-genai":
         dependency = "onnxruntime"
diff --git a/test/python/cpu/ort/requirements.txt b/test/python/cpu/ort/requirements.txt
index 80f6942c8..755b2c592 100644
--- a/test/python/cpu/ort/requirements.txt
+++ b/test/python/cpu/ort/requirements.txt
@@ -1,2 +1,2 @@
 # -i https://aiinfra.pkgs.visualstudio.com/PublicPackages/_packaging/ORT-Nightly/pypi/simple/
-onnxruntime==1.20.0
+onnxruntime==1.20.1
diff --git a/test/python/cuda/ort/requirements.txt b/test/python/cuda/ort/requirements.txt
index 8d73885d7..37ab4707c 100644
--- a/test/python/cuda/ort/requirements.txt
+++ b/test/python/cuda/ort/requirements.txt
@@ -1,2 +1,2 @@
 # -i https://aiinfra.pkgs.visualstudio.com/PublicPackages/_packaging/ORT-Nightly/pypi/simple/
-onnxruntime-gpu==1.20.0
+onnxruntime-gpu==1.20.1
diff --git a/test/python/directml/ort/requirements.txt b/test/python/directml/ort/requirements.txt
index 73fdc9167..3600162e3 100644
--- a/test/python/directml/ort/requirements.txt
+++ b/test/python/directml/ort/requirements.txt
@@ -1,2 +1,2 @@
 # -i https://aiinfra.pkgs.visualstudio.com/PublicPackages/_packaging/ORT-Nightly/pypi/simple/
-onnxruntime-directml==1.20.0
+onnxruntime-directml==1.20.1
diff --git a/test/python/macos/ort/requirements.txt b/test/python/macos/ort/requirements.txt
index 5dfa4f3a8..1f9b1e01b 100644
--- a/test/python/macos/ort/requirements.txt
+++ b/test/python/macos/ort/requirements.txt
@@ -1,2 +1,2 @@
 # -i https://aiinfra.pkgs.visualstudio.com/PublicPackages/_packaging/ORT-Nightly/pypi/simple/
-onnxruntime==1.20.0
\ No newline at end of file
+onnxruntime==1.20.1
\ No newline at end of file