diff --git a/.github/workflows/CI.yml b/.github/workflows/CI.yml
index a1498e9d..e6b7a7d6 100644
--- a/.github/workflows/CI.yml
+++ b/.github/workflows/CI.yml
@@ -113,22 +113,33 @@ jobs:
           TARGET_TRIPLE: ${{ matrix.conf.target-triple }}
           WORKSPACE: ${{ github.workspace }}
           BLOSC2_INSTALL_PREFIX: ${{ github.workspace }}/blosc2
+          ISAL_INSTALL_PREFIX: ${{ github.workspace }}/isal
         run: |
           sudo apt update
           sudo apt install ninja-build -y
 
           echo "BLOSC2_INSTALL_PREFIX=$BLOSC2_INSTALL_PREFIX" >> $GITHUB_ENV
-          echo "LD_LIBRARY_PATH=$LD_LIBRARY_PATH:$BLOSC2_INSTALL_PREFIX/lib:$BLOSC2_INSTALL_PREFIX/lib64" >> $GITHUB_ENV
+          echo "ISAL_INSTALL_PREFIX=$ISAL_INSTALL_PREFIX" >> $GITHUB_ENV
+
+          echo "LD_LIBRARY_PATH=$LD_LIBRARY_PATH:$BLOSC2_INSTALL_PREFIX/lib:$BLOSC2_INSTALL_PREFIX/lib64:$ISAL_INSTALL_PREFIX/lib:$ISAL_INSTALL_PREFIX/lib64" >> $GITHUB_ENV
 
           # maturin action fails building blosc2 for armv7 and aarch64
           # so we'll just use 'cross' to build and pass it in for the action for all archs
           # nothing special for the revision pin, just deterministic install
           cargo install cross --git https://github.com/cross-rs/cross --rev 6d097fb
+
+          # Build blosc2
           cross build --release --target $TARGET_TRIPLE --package blosc2-sys --target-dir build
           blosc2_sys_dir=$(ls build/$TARGET_TRIPLE/release/build/ | grep blosc2-sys)
           mv $WORKSPACE/build/$TARGET_TRIPLE/release/build/$blosc2_sys_dir/out $BLOSC2_INSTALL_PREFIX
           tree -L 2 $BLOSC2_INSTALL_PREFIX
 
+          # Build isal
+          cross build --release --target $TARGET_TRIPLE --package isal-sys --target-dir build
+          isal_sys_dir=$(ls build/$TARGET_TRIPLE/release/build/ | grep isal-sys)
+          mv $WORKSPACE/build/$TARGET_TRIPLE/release/build/$isal_sys_dir/out $ISAL_INSTALL_PREFIX
+          tree -L 2 $ISAL_INSTALL_PREFIX
+
       - name: Rust Tests
         if: matrix.conf.target == 'x86_64' && !startsWith(matrix.python-version, 'pypy') && matrix.python-version == '3.12'
         run: cargo test
@@ -139,9 +150,14 @@ jobs:
         with:
           target: ${{ matrix.conf.target }}
           manylinux: ${{ matrix.conf.manylinux }}
-          docker-options: -e BLOSC2_INSTALL_PREFIX=${{ github.workspace }}/blosc2 -e LD_LIBRARY_PATH=${{ github.workspace }}/blosc2/lib:${{ github.workspace }}/blosc2/lib64
+          docker-options: |
+            -e BLOSC2_INSTALL_PREFIX=${{ github.workspace }}/blosc2 \
+            -e ISAL_INSTALL_PREFIX=${{ github.workspace }}/isal \
+            -e LD_LIBRARY_PATH=${{ github.workspace }}/blosc2/lib:${{ github.workspace }}/blosc2/lib64:${{ github.workspace }}/isal/lib:${{ github.workspace }}/isal/lib64
           args: -i ${{ matrix.python-version }} --release --out dist --features use-system-blosc2-static
-          before-script-linux: ls -l $BLOSC2_INSTALL_PREFIX
+          before-script-linux: |
+            ls -l $BLOSC2_INSTALL_PREFIX
+            ls -l $ISAL_INSTALL_PREFIX
 
       - name: Build wheel (Windows)
         if: runner.os == 'Windows'
diff --git a/Cross.toml b/Cross.toml
new file mode 100644
index 00000000..2e94053f
--- /dev/null
+++ b/Cross.toml
@@ -0,0 +1,15 @@
+[target.x86_64-unknown-linux-musl]
+pre-build = [
+  "apt update",
+  "apt install -y nasm"
+]
+[target.s390x-unknown-linux-gnu]
+pre-build = [
+  "apt update",
+  "apt install -y nasm"
+]
+[target.aarch64-unknown-linux-musl]
+pre-build = [
+  "apt update",
+  "apt install -y nasm"
+]