diff --git a/libvirt/tests/cfg/memory/memory_devices/virtio_mem_coldplug_and_unplug.cfg b/libvirt/tests/cfg/memory/memory_devices/virtio_mem_coldplug_and_unplug.cfg
new file mode 100644
index 0000000000..9b7b4b416c
--- /dev/null
+++ b/libvirt/tests/cfg/memory/memory_devices/virtio_mem_coldplug_and_unplug.cfg
@@ -0,0 +1,84 @@
+- memory.devices.virtio_mem.coldplug_and_unplug:
+    type = virtio_mem_coldplug_and_unplug
+    no s390-virtio
+    start_vm = "no"
+    mem_model = "virtio-mem"
+    target_size = 524288
+    request_size = 524288
+    size_unit = 'KiB'
+    request_unit = 'KiB'
+    block_unit = 'KiB'
+    plug_size_unit = 'KiB'
+    plug_request_unit = 'KiB'
+    plug_block_unit = 'KiB'
+    mem_value = 2097152
+    current_mem = 2097152
+    numa_mem = 1048576
+    max_mem = 4194304
+    max_mem_slots = 16
+    max_dict = '"max_mem_rt": ${max_mem}, "max_mem_rt_slots": ${max_mem_slots}, "max_mem_rt_unit": "KiB"'
+    numa_dict = "'vcpu': 4,'cpu':{'numa_cell': [{'id': '0', 'cpus': '0-1', 'memory': '${numa_mem}'}, {'id': '1', 'cpus': '2-3', 'memory': '${numa_mem}'}]}"
+    vm_attrs = {${numa_dict},${max_dict},'memory_unit':'KiB','memory':${mem_value},'current_mem':${current_mem},'current_mem_unit':'KiB'}
+    numa_xpath = [{'element_attrs':[".//cell[@unit='KiB']",".//cell[@id='0']",".//cell[@memory='${numa_mem}']"]}]
+    base = '0x100000000'
+    plug_option = " --config"
+    required_kernel = [5.14.0,)
+    guest_required_kernel = [5.8.0,)
+    func_supported_since_libvirt_ver = (8, 0, 0)
+    func_supported_since_qemu_kvm_ver = (6, 2, 0)
+    variants case:
+        - with_addr:
+            plug_target_size = 1048576
+            plug_request_size = 1048576
+            addr_dict = "'address':{'attrs': {'base': '${base}'}}"
+            virtio_dict = {'mem_model':'${mem_model}','target': {${addr_dict},'size':${target_size}, 'size_unit':'${size_unit}', 'node':0,'requested_size': ${request_size},'requested_unit':'${request_unit}', 'block_size': %s, 'block_unit':'${block_unit}'}}
+            unplug_dict = ${virtio_dict}
+            plug_dict = {'mem_model':'${mem_model}','target': {${addr_dict},'size':${plug_target_size},'requested_size': ${plug_request_size}, 'block_size': %s, 'size_unit':'${plug_size_unit}','requested_unit':'${plug_request_unit}','block_unit':'${plug_block_unit}','node':0}}
+            virtio_xpath = [{'element_attrs':["./devices/memory/target/size[@unit='${size_unit}']"],'text':'${target_size}'},{'element_attrs':[".//memory/target/block[@unit='${block_unit}']"],'text':'%s'}, {'element_attrs':[".//memory/target/requested[@unit='${request_unit}']"],'text':'${request_size}'},{'element_attrs':[".//memory/target/address[@base='${base}']"]}]
+            unplug_xpath = ${virtio_xpath}
+            plug_xpath = [{'element_attrs':[".//memory/target/size[@unit='${plug_size_unit}']"],'text':'${plug_target_size}'},{'element_attrs':[".//memory/target/block[@unit='${block_unit}']"],'text':'%s'}, {'element_attrs':[".//memory/target/requested[@unit='${plug_request_unit}']"],'text':'${plug_request_size}'},{'element_attrs':[".//memory/target/address[@base='${base}']"]}]
+        - source_and_mib:
+            target_size = 512
+            request_size = 512
+            size_unit = 'MiB'
+            request_unit = 'MiB'
+            plug_target_size = 1024
+            plug_request_size = 1024
+            plug_size_unit = 'MiB'
+            plug_request_unit = 'MiB'
+            plug_block_unit = 'KiB'
+            nodemask = '0'
+            source_dict = "'source': {'nodemask': '0','pagesize': 4, 'pagesize_unit':'KiB'}"
+            virtio_dict = {'mem_model':'${mem_model}',${source_dict}, 'target': {'size':${target_size}, 'size_unit':'${size_unit}','requested_unit':'${request_unit}','block_unit':'${block_unit}','node':1,'requested_size': ${request_size}, 'block_size': %s}}
+            unplug_dict = ${virtio_dict}
+            plug_dict = {'mem_model':'${mem_model}',${source_dict},'target': {'size':${plug_target_size},'requested_size': ${plug_request_size}, 'block_size': %s, 'size_unit':'${plug_size_unit}','requested_unit':'${plug_request_unit}','block_unit':'${plug_block_unit}','node':1}}
+            virtio_xpath = [{'element_attrs':[".//memory/target/size[@unit='KiB']"],'text':'%s'},{'element_attrs':[".//memory/target/block[@unit='KiB']"],'text':'%s'}, {'element_attrs':[".//memory/target/requested[@unit='KiB']"],'text':'%s'}, {'element_attrs':[".//memory/source/pagesize"]}, {'element_attrs':[".//memory/source/nodemask"],'text':'${nodemask}'}]
+            unplug_xpath = ${virtio_xpath}
+            plug_xpath = [{'element_attrs':[".//memory/target/size[@unit='KiB']"],'text':'%s'},{'element_attrs':[".//memory/target/block[@unit='KiB']"],'text':'%s'}, {'element_attrs':[".//memory/target/requested[@unit='KiB']"],'text':'%s'}]
+        - unplug_none_dev:
+            addr_dict = "'address':{'attrs': {'base': '${base}'}}"
+            virtio_dict = {'mem_model':'${mem_model}', 'target': {'size':${target_size}, 'size_unit':'KiB', ${addr_dict}, 'node':0,'requested_size': ${request_size}, 'block_size': %s}}
+            unplug_request_size = 0
+            unplug_dict = {'mem_model':'${mem_model}', 'target': {'requested_size': ${unplug_request_size}, 'size':${target_size}, 'size_unit':'KiB', ${addr_dict}, 'node':0,'block_size': %s}}
+            unplug_error = "matching memory device was not found"
+            virtio_xpath = [{'element_attrs':[".//memory/target/size[@unit='${size_unit}']"],'text':'${target_size}'},{'element_attrs':[".//memory/target/block[@unit='${block_unit}']"],'text':'%s'}, {'element_attrs':[".//memory/target/requested[@unit='${request_unit}']"],'text':'${request_size}'},{'element_attrs':[".//memory/target/address[@base='${base}']"]}]
+            unplug_xpath = [{'element_attrs':[".//memory/target/size[@unit='${size_unit}']"],'text':'${target_size}'},{'element_attrs':[".//memory/target/block[@unit='${plug_block_unit}']"],'text':'%s'}, {'element_attrs':[".//memory/target/requested[@unit='${plug_request_unit}']"],'text':'${unplug_request_size}'},{'element_attrs':[".//memory/target/address[@base='${base}']"]}]
+        - plug_exceeded_max_mem:
+            target_size = 1572864
+            request_size = 1572864
+            plug_target_size = 1024
+            plug_request_size = 1024
+            virtio_dict = {'mem_model':'${mem_model}', 'target': {'size':${target_size}, 'size_unit':'KiB','node':1,'requested_size': ${request_size}, 'block_size': %s}}
+            plug_size_unit = 'MiB'
+            plug_request_unit = 'MiB'
+            plug_dict = {'mem_model':'${mem_model}','target': {'size':${plug_target_size},'requested_size': ${plug_request_size}, 'block_size': %s, 'size_unit':'${plug_size_unit}','requested_unit':'${plug_request_unit}','block_unit':'${plug_block_unit}','node':1}}
+            virtio_xpath = [{'element_attrs':[".//memory/target/size[@unit='${size_unit}']"],'text':'${target_size}'},{'element_attrs':[".//memory/target/block[@unit='${block_unit}']"],'text':'%s'}, {'element_attrs':[".//memory/target/requested[@unit='${request_unit}']"],'text':'${request_size}'}]
+            plug_xpath = [{'element_attrs':[".//memory/target/size[@unit='${size_unit}']"],'text':'%s'},{'element_attrs':[".//memory/target/block[@unit='${block_unit}']"],'text':'%s'}, {'element_attrs':[".//memory/target/requested[@unit='${request_unit}']"],'text':'%s'}]
+            plug_error = "Attaching memory device with size '\S+' would exceed domain's maxMemory config size '${max_mem}'"
+        - duplicate_addr:
+            addr_dict = "'address':{'attrs': {'base': '0x100000000'}}"
+            virtio_dict = {'mem_model':'${mem_model}', 'target': {${addr_dict},'size':${target_size}, 'size_unit':'KiB', ${addr_dict}, 'node':0,'requested_size': ${request_size}, 'block_size': %s}}
+            plug_dict = ${virtio_dict}
+            plug_error = "unsupported configuration: memory device address [0x100000000:0x108000000] overlaps with other memory device (0x100000000)"
+            virtio_xpath = [{'element_attrs':[".//memory/target/size[@unit='${size_unit}']"],'text':'${target_size}'},{'element_attrs':[".//memory/target/block[@unit='${block_unit}']"],'text':'%s'}, {'element_attrs':[".//memory/target/requested[@unit='${request_unit}']"],'text':'${request_size}'},{'element_attrs':[".//memory/target/address[@base='${base}']"]}]
+            plug_xpath = ${virtio_xpath}
diff --git a/libvirt/tests/src/memory/memory_devices/virtio_mem_coldplug_and_unplug.py b/libvirt/tests/src/memory/memory_devices/virtio_mem_coldplug_and_unplug.py
new file mode 100644
index 0000000000..4e6c4cba76
--- /dev/null
+++ b/libvirt/tests/src/memory/memory_devices/virtio_mem_coldplug_and_unplug.py
@@ -0,0 +1,193 @@
+# ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
+#
+#   Copyright Redhat
+#
+#   SPDX-License-Identifier: GPL-2.0
+
+#   Author: Nannan Li <nanli@redhat.com>
+#
+# ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
+
+from avocado.utils import memory
+
+from virttest import virsh
+from virttest.libvirt_xml import vm_xml
+from virttest.utils_test import libvirt
+from virttest.utils_libvirt import libvirt_vmxml
+
+from provider.memory import memory_base
+
+
+def adjust_virtio_params(params):
+    """
+    Adjust all virtio related size and xpath.
+
+    :param params: dict wrapped with params.
+    """
+    plug_target_size = int(params.get('plug_target_size', 0))
+    plug_request_size = int(params.get('plug_request_size', 0))
+    target_size, request_size = int(params.get('target_size')), int(params.get('request_size'))
+    plug_size_unit = params.get('plug_size_unit')
+    plug_request_unit = params.get('plug_request_unit')
+    size_unit, request_unit = params.get('size_unit'), params.get('request_unit')
+
+    def _convert_size(curr_size, curr_unit, var_str):
+        if curr_unit != "KiB":
+            new_size = memory_base.convert_data_size(str(curr_size) + curr_unit)
+            params.update({var_str: int(new_size)})
+
+    _convert_size(target_size, size_unit, 'target_size')
+    _convert_size(request_size, request_unit, 'request_size')
+    _convert_size(plug_target_size, plug_size_unit, 'plug_target_size')
+    _convert_size(plug_request_size, plug_request_unit, 'plug_request_size')
+
+
+def adjust_virtio_xpath(params):
+    """
+    Adjust all expected virtio xpath in different scenarios.
+
+    :param params: dict wrapped with params.
+    :return virtio_xpath, unplug_xpath, plug_xpath, expected defined virtio xpath,
+    expected plugged virtio xpath, expected unplugged virtio xpath.
+    """
+    default_hugepage_size = memory.get_huge_page_size()
+    adjust_virtio_params(params)
+
+    plug_target_size = params.get('plug_target_size')
+    plug_request_size = params.get('plug_request_size')
+    target_size, request_size = params.get('target_size'), params.get('request_size')
+    case = params.get("case")
+    virtio_xpath = params.get("virtio_xpath")
+    unplug_xpath = params.get("unplug_xpath")
+    plug_xpath = params.get("plug_xpath")
+
+    if case == "source_and_mib":
+        virtio_xpath = virtio_xpath % (target_size, default_hugepage_size,
+                                       request_size)
+        unplug_xpath = eval(virtio_xpath)
+        plug_xpath = eval(plug_xpath % (plug_target_size, default_hugepage_size,
+                                        plug_request_size))
+    elif case == "plug_exceeded_max_mem":
+        virtio_xpath = virtio_xpath % default_hugepage_size
+        plug_xpath = eval(plug_xpath % (plug_target_size, default_hugepage_size,
+                                        plug_request_size))
+    else:
+        virtio_xpath = virtio_xpath % default_hugepage_size
+        if unplug_xpath:
+            unplug_xpath = eval(unplug_xpath % default_hugepage_size)
+        if plug_xpath:
+            plug_xpath = eval(plug_xpath % default_hugepage_size)
+    return eval(virtio_xpath), unplug_xpath, plug_xpath
+
+
+def check_xpath_unexist(test, vmxml, not_exist_path):
+    """
+    Check specific xpath info not exist in guest xml.
+
+    :param test: test object.
+    :param vmxml: current guest xml.
+    :param not_exist_path: The xpath that should not exist in guest.
+    """
+    if libvirt_vmxml.check_guest_xml_by_xpaths(
+            vmxml, not_exist_path, ignore_status=True):
+        test.fail("Expect to not get %s in guest" % not_exist_path)
+
+
+def run(test, params, env):
+    """
+    Verify virtio-mem memory device cold-plug and cold-unplug
+    with different configs
+    """
+    def setup_test():
+        """
+        Check Versions.
+        """
+        test.log.info("TEST_SETUP: Check related version")
+        memory_base.check_supported_version(params, test, vm)
+
+    def run_test():
+        """
+        Define guest, then cold unplug and cold plug virtio mem device.
+        """
+        test.log.info("TEST_SETUP1: Define guest")
+        vmxml = vm_xml.VMXML.new_from_inactive_dumpxml(vm_name)
+        vmxml.setup_attrs(**vm_attrs)
+        vmxml.devices = vmxml.devices.append(
+            libvirt_vmxml.create_vm_device_by_type('memory', virtio_dict))
+        virsh.define(vmxml.xml, debug=True, ignore_status=False)
+
+        test.log.info("TEST_STEP2: Check guest xml")
+        virtio_xpath, unplug_xpath, plug_xpath = adjust_virtio_xpath(params)
+        vmxml = vm_xml.VMXML.new_from_inactive_dumpxml(vm_name)
+        libvirt_vmxml.check_guest_xml_by_xpaths(vmxml, numa_xpath+virtio_xpath)
+
+        if unplug_dict:
+            test.log.info("TEST_SETUP3,4:Cold unplug a virtio-mem and check xml")
+            cold_unplug_obj = libvirt_vmxml.create_vm_device_by_type(
+                'memory', unplug_dict)
+            ret = virsh.detach_device(vm.name, cold_unplug_obj.xml,
+                                      flagstr=plug_option, debug=True)
+
+            vmxml = vm_xml.VMXML.new_from_inactive_dumpxml(vm_name)
+            if unplug_error:
+                libvirt.check_result(ret, unplug_error)
+                libvirt_vmxml.check_guest_xml_by_xpaths(vmxml, numa_xpath+virtio_xpath)
+            else:
+                libvirt.check_exit_status(ret)
+                check_xpath_unexist(test, vmxml, unplug_xpath)
+
+        if plug_dict:
+            test.log.info("TEST_SETUP5-7: Cold plug virtio-mem and check xml")
+            cold_plug_obj = libvirt_vmxml.create_vm_device_by_type(
+                'memory', plug_dict)
+            ret = virsh.attach_device(vm.name, cold_plug_obj.xml,
+                                      flagstr=plug_option, debug=True)
+            if case in ["with_addr", "source_and_mib", "duplicate_addr"]:
+                vmxml = vm_xml.VMXML.new_from_inactive_dumpxml(vm_name)
+                if plug_error:
+                    libvirt.check_result(ret, plug_error, any_error=True)
+                    libvirt_vmxml.check_guest_xml_by_xpaths(vmxml, numa_xpath+virtio_xpath)
+                    if case != "duplicate_addr":
+                        check_xpath_unexist(test, vmxml, plug_xpath)
+                else:
+                    libvirt.check_exit_status(ret)
+                    libvirt_vmxml.check_guest_xml_by_xpaths(vmxml, numa_xpath+plug_xpath)
+            elif case in ["plug_exceeded_max_mem"]:
+                for plug_time in range(0, 3):
+                    ret = virsh.attach_device(vm.name, cold_plug_obj.xml,
+                                              flagstr=plug_option, debug=True)
+                    if plug_time == 2:
+                        libvirt.check_result(ret, plug_error)
+
+    def teardown_test():
+        """
+        Clean data.
+        """
+        test.log.info("TEST_TEARDOWN: Clean up env.")
+        bkxml.sync()
+
+    vm_name = params.get("main_vm")
+    vm = env.get_vm(vm_name)
+    vmxml = vm_xml.VMXML.new_from_inactive_dumpxml(vm_name)
+    bkxml = vmxml.copy()
+    case = params.get("case")
+    default_hugepage_size = memory.get_huge_page_size()
+
+    plug_option = params.get("plug_option")
+    vm_attrs = eval(params.get('vm_attrs', '{}'))
+    numa_xpath = eval(params.get("numa_xpath", ""))
+    unplug_error = params.get("unplug_error")
+    plug_error = params.get("plug_error")
+    virtio_dict = eval(params.get('virtio_dict', '{}') % default_hugepage_size)
+    unplug_dict = params.get('unplug_dict')
+    plug_dict = params.get('plug_dict')
+
+    unplug_dict = eval(unplug_dict % default_hugepage_size) if unplug_dict else ''
+    plug_dict = eval(plug_dict % default_hugepage_size) if plug_dict else ''
+
+    try:
+        setup_test()
+        run_test()
+
+    finally:
+        teardown_test()