diff --git a/lib/internal/streams/duplexify.js b/lib/internal/streams/duplexify.js
index 76347cf5579448..aa2da92e1d80af 100644
--- a/lib/internal/streams/duplexify.js
+++ b/lib/internal/streams/duplexify.js
@@ -218,7 +218,7 @@ module.exports = function duplexify(body, name) {
 };
 
 function fromAsyncGen(fn, destructor) {
-  let { promise, resolve } = PromiseWithResolvers();
+  let { promise, resolve, reject } = PromiseWithResolvers();
   const ac = new AbortController();
   const signal = ac.signal;
 
@@ -231,7 +231,7 @@ function fromAsyncGen(fn, destructor) {
       if (done) return;
       if (signal.aborted)
         throw new AbortError(undefined, { cause: signal.reason });
-      ({ promise, resolve } = PromiseWithResolvers());
+      ({ promise, resolve, reject } = PromiseWithResolvers());
       // Next line will "break" the loop if the generator is returned/thrown.
       yield chunk;
     }
@@ -242,6 +242,13 @@ function fromAsyncGen(fn, destructor) {
     try {
       return await originalReturn.call(this, value);
     } finally {
+      if (resolve) {
+        const _resolve = resolve;
+        resolve = null;
+        reject = null;
+        _resolve({ done: true, cb: () => {} });
+      }
+
       if (promise) {
         const _promise = promise;
         promise = null;
@@ -258,13 +265,22 @@ function fromAsyncGen(fn, destructor) {
     try {
       return await originalThrow.call(this, err);
     } finally {
+      // asyncGenerator.throw(undefined) should cause a callback error
+      const error = err || new AbortError();
+
+      if (reject) {
+        const _reject = reject;
+        reject = null;
+        resolve = null;
+        _reject(error);
+      }
+
       if (promise) {
         const _promise = promise;
         promise = null;
         const { cb } = await _promise;
 
-        // asyncGenerator.throw(undefined) should cause a callback error
-        process.nextTick(cb, err ?? new AbortError());
+        process.nextTick(cb, error);
       }
     }
   };
@@ -274,14 +290,24 @@ function fromAsyncGen(fn, destructor) {
   return {
     value,
     write(chunk, encoding, cb) {
-      const _resolve = resolve;
-      resolve = null;
-      _resolve({ chunk, done: false, cb });
+      if (resolve) {
+        const _resolve = resolve;
+        resolve = null;
+        reject = null;
+        _resolve({ chunk, done: false, cb });
+      } else {
+        cb(new AbortError());
+      }
     },
     final(cb) {
-      const _resolve = resolve;
-      resolve = null;
-      _resolve({ done: true, cb });
+      if (resolve) {
+        const _resolve = resolve;
+        resolve = null;
+        reject = null;
+        _resolve({ done: true, cb });
+      } else {
+        cb(new AbortError());
+      }
     },
     destroy(err, cb) {
       ac.abort();
diff --git a/test/parallel/test-stream-pipeline.js b/test/parallel/test-stream-pipeline.js
index 2ee323a934606e..1cbff5bd70a819 100644
--- a/test/parallel/test-stream-pipeline.js
+++ b/test/parallel/test-stream-pipeline.js
@@ -1682,7 +1682,7 @@ tmpdir.refresh();
 }
 
 {
-  // See https://github.com/nodejs/node/issues/51540 for the following 2 tests
+  // See https://github.com/nodemakejs/node/issues/51540 for the following 2 tests
   const src = new Readable();
   const dst = new Writable({
     destroy(error, cb) {
@@ -1723,3 +1723,30 @@ tmpdir.refresh();
   });
   src.destroy(new Error('problem'));
 }
+
+{
+  async function* myAsyncGenerator(ag) {
+    for await (const data of ag) {
+      yield data;
+    }
+  }
+
+  const duplexStream = Duplex.from(myAsyncGenerator);
+
+  const r = new Readable({
+    read() {
+      this.push('data1\n');
+      throw new Error('booom');
+    },
+  });
+
+  const w = new Writable({
+    write(chunk, encoding, callback) {
+      callback();
+    },
+  });
+
+  pipeline(r, duplexStream, w, common.mustCall((err) => {
+    assert.deepStrictEqual(err, new Error('booom'));
+  }));
+}