diff --git a/test/sequential/sequential.status b/test/sequential/sequential.status
index 073b29cce8dbca..6b9d452505f76f 100644
--- a/test/sequential/sequential.status
+++ b/test/sequential/sequential.status
@@ -49,10 +49,6 @@ test-tls-securepair-client: PASS, FLAKY
 # https://github.com/nodejs/node/issues/49933
 test-watch-mode-inspect: SKIP
 
-[$arch==s390x]
-# https://github.com/nodejs/node/issues/41286
-test-performance-eventloopdelay: PASS, FLAKY
-
 [$system==linux && $arch==ppc64]
 # https://github.com/nodejs/node/issues/50740
 test-single-executable-application-assets-raw: PASS, FLAKY
diff --git a/test/sequential/test-performance-eventloopdelay.js b/test/sequential/test-performance-eventloopdelay.js
index 0bc1758113e480..0d38300d7b3a15 100644
--- a/test/sequential/test-performance-eventloopdelay.js
+++ b/test/sequential/test-performance-eventloopdelay.js
@@ -3,6 +3,7 @@
 
 const common = require('../common');
 const assert = require('assert');
+const os = require('os');
 const {
   monitorEventLoopDelay
 } = require('perf_hooks');
@@ -51,9 +52,13 @@ const { sleep } = require('internal/util');
 }
 
 {
+  const s390x = os.arch() === 's390x';
   const histogram = monitorEventLoopDelay({ resolution: 1 });
   histogram.enable();
   let m = 5;
+  if (s390x) {
+    m = m * 2;
+  }
   function spinAWhile() {
     sleep(1000);
     if (--m > 0) {