How can I generate a .hic contact matrix at the fragment level using Micro-C data?

[hanshanmengqi]

Hello,

Thank you for providing such helpful software!

I have a question about generating a .hic contact matrix with fragment resolution using Micro-C data. As shown in the attached figure, the .hic file typically allows us to visualize contact matrices at various resolutions (including the fragment level).

However, since Micro-C data does not have restriction fragment file, I am unsure how to generate a .hic contact matrix at the fragment level.

Do you have any suggestions or insights on how to address this issue?

Thank you for your help!

Best regards,
Han