diff --git a/jsonrpc/endpoints_eth.go b/jsonrpc/endpoints_eth.go
index 5639e842e3..ddf914f6a3 100644
--- a/jsonrpc/endpoints_eth.go
+++ b/jsonrpc/endpoints_eth.go
@@ -111,13 +111,13 @@ func (e *EthEndpoints) Call(arg *types.TxArgs, blockArg *types.BlockNumberOrHash
 
 		// X Layer LRU
 		if lru_xlayer.GetConfig().Enable {
-			ret, errValue, ok := getCallResultFromLRU(blockToProcess, tx.To(), tx.Data())
+			ret, errValue, ok := getCallResultFromLRU(blockToProcess, sender, tx)
 			if ok {
 				log.Infof("Call result from LRU cache: %v, %v", ret, errValue)
 				return ret, errValue
 			}
 			defer func() {
-				setCallResultToLRU(blockToProcess, tx.To(), tx.Data(), respRet, errRet)
+				setCallResultToLRU(blockToProcess, sender, tx, respRet, errRet)
 			}()
 		}
 
diff --git a/jsonrpc/endpoints_eth_lru_xlayer.go b/jsonrpc/endpoints_eth_lru_xlayer.go
index 7f8951f819..87206386e4 100644
--- a/jsonrpc/endpoints_eth_lru_xlayer.go
+++ b/jsonrpc/endpoints_eth_lru_xlayer.go
@@ -1,22 +1,23 @@
 package jsonrpc
 
 import (
-	"crypto/md5"
 	"fmt"
 
 	"github.com/0xPolygonHermez/zkevm-node/jsonrpc/lru_xlayer"
 	"github.com/0xPolygonHermez/zkevm-node/jsonrpc/types"
+
 	"github.com/0xPolygonHermez/zkevm-node/log"
 	"github.com/ethereum/go-ethereum/common"
+	ethtypes "github.com/ethereum/go-ethereum/core/types"
 )
 
-func getCallKey(blockNumber *uint64, to *common.Address, input []byte) (string, string) {
-	baseKey := fmt.Sprintf("%d-%s-%s", blockNumber, to.Hex(), md5.Sum(input))
+func getCallKey(blockNumber *uint64, sender common.Address, tx *ethtypes.Transaction) (string, string) {
+	baseKey := fmt.Sprintf("%d-%s-%s", blockNumber, sender.String(), tx.Hash().String())
 	return baseKey + "ret", baseKey + "err"
 }
 
-func getCallResultFromLRU(blockNumber *uint64, to *common.Address, input []byte) (interface{}, types.Error, bool) {
-	retKey, errKey := getCallKey(blockNumber, to, input)
+func getCallResultFromLRU(blockNumber *uint64, sender common.Address, tx *ethtypes.Transaction) (interface{}, types.Error, bool) {
+	retKey, errKey := getCallKey(blockNumber, sender, tx)
 	value, ok := lru_xlayer.GetLRU().Get(retKey)
 	if !ok {
 		return nil, nil, false
@@ -33,8 +34,8 @@ func getCallResultFromLRU(blockNumber *uint64, to *common.Address, input []byte)
 	return value, v, true
 }
 
-func setCallResultToLRU(blockNumber *uint64, to *common.Address, input []byte, value interface{}, errValue types.Error) {
-	retKey, errKey := getCallKey(blockNumber, to, input)
+func setCallResultToLRU(blockNumber *uint64, sender common.Address, tx *ethtypes.Transaction, value interface{}, errValue types.Error) {
+	retKey, errKey := getCallKey(blockNumber, sender, tx)
 	err := lru_xlayer.GetLRU().Set(retKey, value)
 	if err != nil {
 		log.Debugf("Failed to set value to LRU cache call ret: %v", err)