diff --git a/.chloggen/remove-pipelineprofiles.yaml b/.chloggen/remove-pipelineprofiles.yaml
new file mode 100644
index 00000000000..e41dccb4c51
--- /dev/null
+++ b/.chloggen/remove-pipelineprofiles.yaml
@@ -0,0 +1,18 @@
+# One of 'breaking', 'deprecation', 'new_component', 'enhancement', 'bug_fix'
+change_type: breaking
+
+# The name of the component, or a single word describing the area of concern, (e.g. otlpreceiver)
+component: pipeline
+
+# A brief description of the change.  Surround your text with quotes ("") if it needs to start with a backtick (`).
+note: Remove deprecated pipelineprofiles module, use xpipeline instead.
+
+# One or more tracking issues or pull requests related to the change
+issues: [11778]
+
+# Optional: The change log or logs in which this entry should be included.
+# e.g. '[user]' or '[user, api]'
+# Include 'user' if the change is relevant to end users.
+# Include 'api' if there is a change to a library API.
+# Default: '[user]'
+change_logs: [api]
diff --git a/cmd/builder/test/core.builder.yaml b/cmd/builder/test/core.builder.yaml
index 726770fb328..7c80d8b381f 100644
--- a/cmd/builder/test/core.builder.yaml
+++ b/cmd/builder/test/core.builder.yaml
@@ -66,7 +66,6 @@ replaces:
   - go.opentelemetry.io/collector/pdata/pprofile => ${WORKSPACE_DIR}/pdata/pprofile
   - go.opentelemetry.io/collector/pdata/testdata => ${WORKSPACE_DIR}/pdata/testdata
   - go.opentelemetry.io/collector/pipeline => ${WORKSPACE_DIR}/pipeline
-  - go.opentelemetry.io/collector/pipeline/pipelineprofiles => ${WORKSPACE_DIR}/pipeline/pipelineprofiles
   - go.opentelemetry.io/collector/pipeline/xpipeline => ${WORKSPACE_DIR}/pipeline/xpipeline
   - go.opentelemetry.io/collector/processor => ${WORKSPACE_DIR}/processor
   - go.opentelemetry.io/collector/processor/processortest => ${WORKSPACE_DIR}/processor/processortest
diff --git a/pipeline/pipelineprofiles/Makefile b/pipeline/pipelineprofiles/Makefile
deleted file mode 100644
index ded7a36092d..00000000000
--- a/pipeline/pipelineprofiles/Makefile
+++ /dev/null
@@ -1 +0,0 @@
-include ../../Makefile.Common
diff --git a/pipeline/pipelineprofiles/config.go b/pipeline/pipelineprofiles/config.go
deleted file mode 100644
index a81887086b7..00000000000
--- a/pipeline/pipelineprofiles/config.go
+++ /dev/null
@@ -1,12 +0,0 @@
-// Copyright The OpenTelemetry Authors
-// SPDX-License-Identifier: Apache-2.0
-
-// Deprecated: [0.116.0] Use go.opentelemetry.io/collector/pipeline/xpipeline instead.
-package pipelineprofiles // import "go.opentelemetry.io/collector/pipeline/pipelineprofiles"
-
-import (
-	"go.opentelemetry.io/collector/pipeline/internal/globalsignal"
-)
-
-// Deprecated: [0.116.0] Use xpipeline.SignalProfiles instead.
-var SignalProfiles = globalsignal.MustNewSignal("profiles")
diff --git a/pipeline/pipelineprofiles/go.mod b/pipeline/pipelineprofiles/go.mod
deleted file mode 100644
index 51e78fde845..00000000000
--- a/pipeline/pipelineprofiles/go.mod
+++ /dev/null
@@ -1,7 +0,0 @@
-module go.opentelemetry.io/collector/pipeline/pipelineprofiles
-
-go 1.22.0
-
-require go.opentelemetry.io/collector/pipeline v0.116.0
-
-replace go.opentelemetry.io/collector/pipeline => ../
diff --git a/pipeline/pipelineprofiles/go.sum b/pipeline/pipelineprofiles/go.sum
deleted file mode 100644
index 67458fab477..00000000000
--- a/pipeline/pipelineprofiles/go.sum
+++ /dev/null
@@ -1,8 +0,0 @@
-github.com/davecgh/go-spew v1.1.1 h1:vj9j/u1bqnvCEfJOwUhtlOARqs3+rkHYY13jYWTU97c=
-github.com/davecgh/go-spew v1.1.1/go.mod h1:J7Y8YcW2NihsgmVo/mv3lAwl/skON4iLHjSsI+c5H38=
-github.com/pmezard/go-difflib v1.0.0 h1:4DBwDE0NGyQoBHbLQYPwSUPoCMWR5BEzIk/f1lZbAQM=
-github.com/pmezard/go-difflib v1.0.0/go.mod h1:iKH77koFhYxTK1pcRnkKkqfTogsbg7gZNVY4sRDYZ/4=
-github.com/stretchr/testify v1.10.0 h1:Xv5erBjTwe/5IxqUQTdXv5kgmIvbHo3QQyRwhJsOfJA=
-github.com/stretchr/testify v1.10.0/go.mod h1:r2ic/lqez/lEtzL7wO/rwa5dbSLXVDPFyf8C91i36aY=
-gopkg.in/yaml.v3 v3.0.1 h1:fxVm/GzAzEWqLHuvctI91KS9hhNmmWOoWu0XTYJS7CA=
-gopkg.in/yaml.v3 v3.0.1/go.mod h1:K4uyk7z7BCEPqu6E+C64Yfv1cQ7kz7rIZviUmN+EgEM=
diff --git a/versions.yaml b/versions.yaml
index a4f78aef4a2..9a91b6e4a2f 100644
--- a/versions.yaml
+++ b/versions.yaml
@@ -69,7 +69,6 @@ module-sets:
       - go.opentelemetry.io/collector/pdata/pprofile
       - go.opentelemetry.io/collector/pdata/testdata
       - go.opentelemetry.io/collector/pipeline
-      - go.opentelemetry.io/collector/pipeline/pipelineprofiles
       - go.opentelemetry.io/collector/pipeline/xpipeline
       - go.opentelemetry.io/collector/processor
       - go.opentelemetry.io/collector/processor/processortest