diff --git a/crates/oxc_ecmascript/src/constant_evaluation/mod.rs b/crates/oxc_ecmascript/src/constant_evaluation/mod.rs
index a368262908466..ab47066c7de25 100644
--- a/crates/oxc_ecmascript/src/constant_evaluation/mod.rs
+++ b/crates/oxc_ecmascript/src/constant_evaluation/mod.rs
@@ -347,6 +347,27 @@ pub trait ConstantEvaluation<'a> {
                 }
                 None
             }
+            BinaryOperator::Instanceof => {
+                if left.may_have_side_effects() {
+                    return None;
+                }
+
+                let left_ty = ValueType::from(left);
+                if left_ty == ValueType::Undetermined {
+                    return None;
+                }
+                if left_ty == ValueType::Object {
+                    if let Some(right_ident) = right.get_identifier_reference() {
+                        if right_ident.name == "Object" && self.is_global_reference(right_ident) {
+                            return Some(ConstantValue::Boolean(true));
+                        }
+                    }
+                    None
+                } else {
+                    // Non-object types are never instances.
+                    Some(ConstantValue::Boolean(false))
+                }
+            }
             _ => None,
         }
     }
diff --git a/crates/oxc_minifier/src/ast_passes/peephole_fold_constants.rs b/crates/oxc_minifier/src/ast_passes/peephole_fold_constants.rs
index dbff2b5eb207b..3e915b39e0802 100644
--- a/crates/oxc_minifier/src/ast_passes/peephole_fold_constants.rs
+++ b/crates/oxc_minifier/src/ast_passes/peephole_fold_constants.rs
@@ -245,7 +245,8 @@ impl<'a, 'b> PeepholeFoldConstants {
             | BinaryOperator::Division
             | BinaryOperator::Remainder
             | BinaryOperator::Multiplication
-            | BinaryOperator::Exponential => {
+            | BinaryOperator::Exponential
+            | BinaryOperator::Instanceof => {
                 ctx.eval_binary_expression(e).map(|v| ctx.value_to_expr(e.span, v))
             }
             BinaryOperator::Addition => Self::try_fold_add(e, ctx),
@@ -1503,6 +1504,45 @@ mod test {
         test("(+x & 1) & 2", "+x & 0");
     }
 
+    #[test]
+    fn test_fold_instance_of() {
+        // Non object types are never instances of anything.
+        test("64 instanceof Object", "false");
+        test("64 instanceof Number", "false");
+        test("'' instanceof Object", "false");
+        test("'' instanceof String", "false");
+        test("true instanceof Object", "false");
+        test("true instanceof Boolean", "false");
+        test("!0 instanceof Object", "false");
+        test("!0 instanceof Boolean", "false");
+        test("false instanceof Object", "false");
+        test("null instanceof Object", "false");
+        test("undefined instanceof Object", "false");
+        test("NaN instanceof Object", "false");
+        test("Infinity instanceof Object", "false");
+
+        // Array and object literals are known to be objects.
+        test("[] instanceof Object", "true");
+        test("({}) instanceof Object", "true");
+
+        // These cases is foldable, but no handled currently.
+        test_same("new Foo() instanceof Object");
+        // These would require type information to fold.
+        test_same("[] instanceof Foo");
+        test_same("({}) instanceof Foo");
+
+        test("(function() {}) instanceof Object", "true");
+
+        // An unknown value should never be folded.
+        test_same("x instanceof Foo");
+    }
+
+    #[test]
+    fn test_fold_instance_of_additional() {
+        test("(typeof {}) instanceof Object", "false");
+        test("(+{}) instanceof Number", "false");
+    }
+
     #[test]
     fn test_fold_left_child_op() {
         test_same("x & infinity & 2"); // FIXME: want x & 0