diff --git a/.Rbuildignore b/.Rbuildignore
index b1cb9722..24e5e90a 100644
--- a/.Rbuildignore
+++ b/.Rbuildignore
@@ -3,6 +3,7 @@
 ^.*\.Rproj$
 ^\.Rproj\.user$
 ^\.github$
+^\.devcontainer$
 ^\.lycheeignore$
 ^README\.Rmd$
 ^_pkgdown\.yml$
diff --git a/.Rprofile b/.Rprofile
index 4c653784..a94c4d6f 100644
--- a/.Rprofile
+++ b/.Rprofile
@@ -24,19 +24,21 @@ if (Sys.getenv("GITHUB_ACTIONS") != "") {
 Sys.setenv("RENV_CONFIG_SANDBOX_ENABLED" = FALSE)
 Sys.setenv("RENV_CONFIG_AUTO_SNAPSHOT" = FALSE)
 
-.renv_profile <- paste(R.version$major, substr(R.version$minor, 1, 1), sep = ".")
-if (!file.exists("./renv/profile")) {
-  if (.renv_profile %in% c("4.1", "4.2", "4.3")) {
-    message("Set renv profile to `", .renv_profile, "`")
-    Sys.setenv("RENV_PROFILE" = .renv_profile)
+if (!Sys.getenv("RENV_AUTOLOADER_ENABLED") %in% c("false", "FALSE")) {
+  .renv_profile <- paste(R.version$major, substr(R.version$minor, 1, 1), sep = ".")
+  if (!file.exists("./renv/profile")) {
+    if (.renv_profile %in% c("4.1", "4.2", "4.3")) {
+      message("Set renv profile to `", .renv_profile, "`")
+      Sys.setenv("RENV_PROFILE" = .renv_profile)
+    } else {
+      message("This repository do not contains the renv profile for your R version.")
+    }
   } else {
-    message("This repository do not contains the renv profile for your R version.")
+    message(
+      "Using renv profile from `renv/profile` file.\n",
+      "The `", readLines("./renv/profile"), "` profile will be used."
+    )
   }
-} else {
-  message(
-    "Using renv profile from `renv/profile` file.\n",
-    "The `", readLines("./renv/profile"), "` profile will be used."
-  )
 }
 
 source("renv/activate.R")
diff --git a/.devcontainer/4.1/devcontainer.json b/.devcontainer/4.1/devcontainer.json
new file mode 100644
index 00000000..e60b4fd9
--- /dev/null
+++ b/.devcontainer/4.1/devcontainer.json
@@ -0,0 +1,95 @@
+{
+	// https://containers.dev/implementors/json_reference/
+	"name": "sdtm.oak (RStudio) container",
+	"image": "ghcr.io/pharmaverse/sdtm.oak-4.1:latest",
+	// Install Dev Container Features. More info: https://containers.dev/features
+	"containerEnv": {
+		"ROOT": "true",
+		"PASSWORD": "rstudio",
+		"DISABLE_AUTH": "true",
+		"RENV_AUTOLOADER_ENABLED": "false"
+	},
+	"features": {
+		"./ca-cert": {},
+		"ghcr.io/rocker-org/devcontainer-features/r-rig:1": {
+			"version": "none",
+			"vscodeRSupport": "full",
+			"installRadian": true,
+			"installVscDebugger": true
+		},
+		"ghcr.io/rocker-org/devcontainer-features/renv-cache:latest": {},
+		"ghcr.io/devcontainers/features/common-utils:2": {
+			"installZsh": true,
+			"configureZshAsDefaultShell": false,
+			"installOhMyZsh": true,
+			"username": "rstudio",
+			"upgradePackages": false
+		},
+		"ghcr.io/mikaello/devcontainer-features/modern-shell-utils:1": {}
+	},
+	"overrideFeatureInstallOrder": [
+		"./ca-cert",
+		"./arm64-repos",
+		"ghcr.io/devcontainers/features/common-utils",
+		"ghcr.io/rocker-org/devcontainer-features/renv-cache",
+		"ghcr.io/rocker-org/devcontainer-features/r-rig",
+		"ghcr.io/mikaello/devcontainer-features/modern-shell-utils"
+	],
+	"init": true,
+	"overrideCommand": false,
+
+	"postCreateCommand": "bash ./.devcontainer/postCreateCommand.sh",
+
+	"postAttachCommand": "rstudio || true",
+
+	"customizations": {
+		"codespaces": {
+			"repositories": {
+			  "pharmaverse/mint": {
+				"permissions": "write-all"
+			  },
+			  "pharmaverse/raw.synthetic.data": {
+				"permissions": "write-all"
+			  }
+			}
+		},
+		"vscode": {
+			"settings": {
+				"r.rterm.linux": "/usr/local/bin/radian",
+				"r.bracketedPaste": true,
+				"editor.bracketPairColorization.enabled": true,
+				"editor.guides.bracketPairs": "active"
+			},
+			"extensions": [
+				"vsls-contrib.codetour",
+				"GitHub.copilot",
+				"GitHub.copilot-chat",
+				// R extensions
+				"ikuyadeu.r",
+				"REditorSupport.r-lsp",
+				// Extra extension
+				"streetsidesoftware.code-spell-checker",
+				"eamodio.gitlens",
+				"cweijan.vscode-office",
+				"donjayamanne.githistory",
+				"GitHub.vscode-github-actions",
+				"GitHub.vscode-pull-request-github",
+				"GitHub.remotehub",
+				"alefragnani.Bookmarks",
+				"vscode-icons-team.vscode-icons"
+			]
+		}
+	},
+
+	// RStudio ports
+	"forwardPorts": [8787],
+	"portsAttributes": {
+		"8787": {
+			"label": "Rstudio",
+			"requireLocalPort": true,
+			"onAutoForward": "openBrowser"
+		}
+	},
+	// Uncomment to connect as root instead. More info: https://aka.ms/dev-containers-non-root
+	"remoteUser": "rstudio"
+}
diff --git a/.devcontainer/4.2/devcontainer.json b/.devcontainer/4.2/devcontainer.json
new file mode 100644
index 00000000..c197bc1b
--- /dev/null
+++ b/.devcontainer/4.2/devcontainer.json
@@ -0,0 +1,95 @@
+{
+	// https://containers.dev/implementors/json_reference/
+	"name": "sdtm.oak R-4.2 (RStudio) container",
+	"image": "ghcr.io/pharmaverse/sdtm.oak-4.2:latest",
+	// Install Dev Container Features. More info: https://containers.dev/features
+	"containerEnv": {
+		"ROOT": "true",
+		"PASSWORD": "rstudio",
+		"DISABLE_AUTH": "true",
+		"RENV_AUTOLOADER_ENABLED": "false"
+	},
+	"features": {
+		"./ca-cert": {},
+		"ghcr.io/rocker-org/devcontainer-features/r-rig:1": {
+			"version": "none",
+			"vscodeRSupport": "full",
+			"installRadian": true,
+			"installVscDebugger": true
+		},
+		"ghcr.io/rocker-org/devcontainer-features/renv-cache:latest": {},
+		"ghcr.io/devcontainers/features/common-utils:2": {
+			"installZsh": true,
+			"configureZshAsDefaultShell": false,
+			"installOhMyZsh": true,
+			"username": "rstudio",
+			"upgradePackages": false
+		},
+		"ghcr.io/mikaello/devcontainer-features/modern-shell-utils:1": {}
+	},
+	"overrideFeatureInstallOrder": [
+		"./ca-cert",
+		"./arm64-repos",
+		"ghcr.io/devcontainers/features/common-utils",
+		"ghcr.io/rocker-org/devcontainer-features/renv-cache",
+		"ghcr.io/rocker-org/devcontainer-features/r-rig",
+		"ghcr.io/mikaello/devcontainer-features/modern-shell-utils"
+	],
+	"init": true,
+	"overrideCommand": false,
+
+	"postCreateCommand": "bash ./.devcontainer/postCreateCommand.sh",
+
+	"postAttachCommand": "rstudio || true",
+
+	"customizations": {
+		"codespaces": {
+			"repositories": {
+			  "pharmaverse/mint": {
+				"permissions": "write-all"
+			  },
+			  "pharmaverse/raw.synthetic.data": {
+				"permissions": "write-all"
+			  }
+			}
+		},
+		"vscode": {
+			"settings": {
+				"r.rterm.linux": "/usr/local/bin/radian",
+				"r.bracketedPaste": true,
+				"editor.bracketPairColorization.enabled": true,
+				"editor.guides.bracketPairs": "active"
+			},
+			"extensions": [
+				"vsls-contrib.codetour",
+				"GitHub.copilot",
+				"GitHub.copilot-chat",
+				// R extensions
+				"ikuyadeu.r",
+				"REditorSupport.r-lsp",
+				// Extra extension
+				"streetsidesoftware.code-spell-checker",
+				"eamodio.gitlens",
+				"cweijan.vscode-office",
+				"donjayamanne.githistory",
+				"GitHub.vscode-github-actions",
+				"GitHub.vscode-pull-request-github",
+				"GitHub.remotehub",
+				"alefragnani.Bookmarks",
+				"vscode-icons-team.vscode-icons"
+			]
+		}
+	},
+
+	// RStudio ports
+	"forwardPorts": [8787],
+	"portsAttributes": {
+		"8787": {
+			"label": "Rstudio",
+			"requireLocalPort": true,
+			"onAutoForward": "openBrowser"
+		}
+	},
+	// Uncomment to connect as root instead. More info: https://aka.ms/dev-containers-non-root
+	"remoteUser": "rstudio"
+}
diff --git a/.devcontainer/arm64-repos/devcontainer-feature.json b/.devcontainer/arm64-repos/devcontainer-feature.json
new file mode 100644
index 00000000..8b9e2b99
--- /dev/null
+++ b/.devcontainer/arm64-repos/devcontainer-feature.json
@@ -0,0 +1,7 @@
+{
+	"name": "arm64 repos",
+	"id": "arm64-repos",
+	"version": "0.1.0",
+	"description": "Fix repos for arm64.",
+	"options": {}
+}
\ No newline at end of file
diff --git a/.devcontainer/arm64-repos/install.sh b/.devcontainer/arm64-repos/install.sh
new file mode 100644
index 00000000..92f74c1e
--- /dev/null
+++ b/.devcontainer/arm64-repos/install.sh
@@ -0,0 +1,22 @@
+#!/bin/bash
+
+set -e
+
+ARCH=$(uname -m)
+
+## source install if using RSPM and arm64 image
+if [ "$ARCH" = "aarch64" ]; then
+
+CRAN="https://cloud.r-project.org"
+
+## Add a default CRAN mirror
+echo "options(repos = c(CRAN = '${CRAN}'), download.file.method = 'libcurl')" >"${R_HOME}/etc/Rprofile.site"
+
+## Set HTTPUserAgent for RSPM (https://github.com/rocker-org/rocker/issues/400)
+cat <<EOF >>"${R_HOME}/etc/Rprofile.site"
+# https://docs.rstudio.com/rspm/admin/serving-binaries/#binaries-r-configuration-linux
+options(HTTPUserAgent = sprintf("R/%s R (%s)", getRversion(), paste(getRversion(), R.version["platform"], R.version["arch"], R.version["os"])))
+EOF
+
+fi
+
diff --git a/.devcontainer/ca-cert/.gitignore b/.devcontainer/ca-cert/.gitignore
new file mode 100644
index 00000000..ee0cb61c
--- /dev/null
+++ b/.devcontainer/ca-cert/.gitignore
@@ -0,0 +1 @@
+*.crt
\ No newline at end of file
diff --git a/.devcontainer/ca-cert/devcontainer-feature.json b/.devcontainer/ca-cert/devcontainer-feature.json
new file mode 100644
index 00000000..7aea7af9
--- /dev/null
+++ b/.devcontainer/ca-cert/devcontainer-feature.json
@@ -0,0 +1,7 @@
+{
+	"name": "CA cert",
+	"id": "ca-cert",
+	"version": "0.1.0",
+	"description": "Copy CA cert into the container.",
+	"options": {}
+}
\ No newline at end of file
diff --git a/.devcontainer/ca-cert/install.sh b/.devcontainer/ca-cert/install.sh
new file mode 100644
index 00000000..6064b36b
--- /dev/null
+++ b/.devcontainer/ca-cert/install.sh
@@ -0,0 +1,11 @@
+#!/bin/sh
+
+set -e
+
+# Copy CA certificate to `/etc/ssl/cert`
+if ls *.crt 1> /dev/null 2>&1; then
+    sudo cp *.crt /usr/local/share/ca-certificates
+    sudo update-ca-certificates
+fi
+
+echo "Done!"
\ No newline at end of file
diff --git a/.devcontainer/devcontainer.json b/.devcontainer/devcontainer.json
new file mode 100644
index 00000000..5b8de048
--- /dev/null
+++ b/.devcontainer/devcontainer.json
@@ -0,0 +1,96 @@
+{
+	// https://containers.dev/implementors/json_reference/
+	"name": "sdtm.oak R-4.3 (RStudio) container",
+	"image": "ghcr.io/pharmaverse/sdtm.oak-4.3:latest",
+	// Install Dev Container Features. More info: https://containers.dev/features
+	"containerEnv": {
+		"ROOT": "true",
+		"PASSWORD": "rstudio",
+		"DISABLE_AUTH": "true",
+		"RENV_AUTOLOADER_ENABLED": "false"
+	},
+	"features": {
+		"./ca-cert": {},
+		"./arm64-repos": {},
+		"ghcr.io/rocker-org/devcontainer-features/r-rig:1": {
+			"version": "none",
+			"vscodeRSupport": "full",
+			"installRadian": true,
+			"installVscDebugger": true
+		},
+		"ghcr.io/rocker-org/devcontainer-features/renv-cache:latest": {},
+		"ghcr.io/devcontainers/features/common-utils:2": {
+			"installZsh": true,
+			"configureZshAsDefaultShell": false,
+			"installOhMyZsh": true,
+			"username": "rstudio",
+			"upgradePackages": false
+		},
+		"ghcr.io/mikaello/devcontainer-features/modern-shell-utils:1": {}
+	},
+	"overrideFeatureInstallOrder": [
+		"./ca-cert",
+		"./arm64-repos",
+		"ghcr.io/devcontainers/features/common-utils",
+		"ghcr.io/rocker-org/devcontainer-features/renv-cache",
+		"ghcr.io/rocker-org/devcontainer-features/r-rig",
+		"ghcr.io/mikaello/devcontainer-features/modern-shell-utils"
+	],
+	"init": true,
+	"overrideCommand": false,
+
+	"postCreateCommand": "bash ./.devcontainer/postCreateCommand.sh",
+
+	"postAttachCommand": "rstudio || true",
+
+	"customizations": {
+		"codespaces": {
+			"repositories": {
+			  "pharmaverse/mint": {
+				"permissions": "read-all"
+			  },
+			  "pharmaverse/raw.synthetic.data": {
+				"permissions": "read-all"
+			  }
+			}
+		},
+		"vscode": {
+			"settings": {
+				"r.rterm.linux": "/usr/local/bin/radian",
+				"r.bracketedPaste": true,
+				"editor.bracketPairColorization.enabled": true,
+				"editor.guides.bracketPairs": "active"
+			},
+			"extensions": [
+				"vsls-contrib.codetour",
+				"GitHub.copilot",
+				"GitHub.copilot-chat",
+				// R extensions
+				"ikuyadeu.r",
+				"REditorSupport.r-lsp",
+				// Extra extension
+				"streetsidesoftware.code-spell-checker",
+				"eamodio.gitlens",
+				"cweijan.vscode-office",
+				"donjayamanne.githistory",
+				"GitHub.vscode-github-actions",
+				"GitHub.vscode-pull-request-github",
+				"GitHub.remotehub",
+				"alefragnani.Bookmarks",
+				"vscode-icons-team.vscode-icons"
+			]
+		}
+	},
+
+	// RStudio ports
+	"forwardPorts": [8787],
+	"portsAttributes": {
+		"8787": {
+			"label": "Rstudio",
+			"requireLocalPort": true,
+			"onAutoForward": "openBrowser"
+		}
+	},
+	// Uncomment to connect as root instead. More info: https://aka.ms/dev-containers-non-root
+	"remoteUser": "rstudio"
+}
diff --git a/.devcontainer/postCreateCommand.sh b/.devcontainer/postCreateCommand.sh
new file mode 100644
index 00000000..8dfe4e23
--- /dev/null
+++ b/.devcontainer/postCreateCommand.sh
@@ -0,0 +1,11 @@
+#!/bin/bash
+
+# move script rstudio into /usr/bin
+sudo cp "$(pwd)/.devcontainer/rstudio.sh" /usr/bin/rstudio
+sudo chmod +x /usr/bin/rstudio
+
+# Restore renv and install staged dependencies
+R -q -e 'renv::restore(lockfile = file.path("renv", "profiles", paste(R.version$major, substr(R.version$minor, 1, 1), sep = "."), "renv.lock")); staged.dependencies::install_deps(staged.dependencies::dependency_table(project = ".", verbose = 1), verbose = 1);'
+
+# Define rstudio default working directory
+jq --arg folder "$(pwd)/" '. + { "initial_working_directory": $folder }' .devcontainer/rstudio-prefs.json > ~/.config/rstudio/rstudio-prefs.json
diff --git a/.devcontainer/rstudio-prefs.json b/.devcontainer/rstudio-prefs.json
new file mode 100644
index 00000000..2d5cce84
--- /dev/null
+++ b/.devcontainer/rstudio-prefs.json
@@ -0,0 +1,8 @@
+{
+	"save_workspace": "never",
+	"always_save_history": false,
+	"reuse_sessions_for_project_links": true,
+	"posix_terminal_shell": "bash",
+	"initial_working_directory": "/workspaces",
+	"show_hidden_files": true
+}
diff --git a/.devcontainer/rstudio.sh b/.devcontainer/rstudio.sh
new file mode 100644
index 00000000..053a247b
--- /dev/null
+++ b/.devcontainer/rstudio.sh
@@ -0,0 +1,5 @@
+#!/bin/bash
+
+$BROWSER "https://${CODESPACE_NAME}-8787.${GITHUB_CODESPACES_PORT_FORWARDING_DOMAIN}"
+
+exit 1