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ChI_DePitta2009.cps
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<body xmlns="http://www.w3.org/1999/xhtml"><h1>ChI model of calcium oscillations</h1>
<p>This is a core model of calcium oscillations dependent on IP3 developed by <a href="https://doi.org/10.1007/s10867-009-9155-y">De Pittà et al. (2009)</a> .</p>
<h2>History</h2>
<p>This model is an extension to a 2-variable model of calcium-induced calcium release by <a href="https://doi.org/10.1006/jtbi.1994.1041">Li and Rinzel</a>, where the active role of IP3 was added (it is constant in the Li-Rinzel model). The Li-Rinzel model was, in its turn, developed as a reduced version of a previous model by <a href="https://doi.org/10.1073/pnas.89.20.9895">De Young and Keizer</a>, which contained a detailed mechanism of the IP3R and has 9 variables. The reduction, based on time scale separation, follows a formalism similar to that used by Hodgkin and Huxley to develop a model of excitability of the neuronal plasma membrane.</p>
<p style="font-size:small"><b>CC0 1.0 Universal</b>: To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. You can copy, modify, distribute and perform the work, even for commercial purposes, all without asking permission. Please refer to <a href="http://creativecommons.org/publicdomain/zero/1.0/" title="Creative Commons CC0">CC0 Public Domain Dedication</a> for more information.</p></body>
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