diff --git a/pybricksdev/ble/pybricks.py b/pybricksdev/ble/pybricks.py
index cb058b9..44d35df 100644
--- a/pybricksdev/ble/pybricks.py
+++ b/pybricksdev/ble/pybricks.py
@@ -328,6 +328,12 @@ def _standard_uuid(short: int) -> str:
 .. availability:: Since Pybricks protocol v1.0.0.
 """
 
+DVC_NAME_UUID = _standard_uuid(0x2A00)
+"""Standard Device Name UUID
+
+.. availability:: Since Pybricks protocol v1.0.0.
+"""
+
 FW_REV_UUID = _standard_uuid(0x2A26)
 """Standard Firmware Revision String characteristic UUID
 
diff --git a/pybricksdev/cli/__init__.py b/pybricksdev/cli/__init__.py
index 198f52b..f0f341e 100644
--- a/pybricksdev/cli/__init__.py
+++ b/pybricksdev/cli/__init__.py
@@ -171,10 +171,12 @@ def add_parser(self, subparsers: argparse._SubParsersAction):
             )
 
     async def run(self, args: argparse.Namespace):
-        from ..ble import find_device
+        from usb.core import find as find_usb
+
+        from ..ble import find_device as find_ble
         from ..connections.ev3dev import EV3Connection
         from ..connections.lego import REPLHub
-        from ..connections.pybricks import PybricksHubBLE
+        from ..connections.pybricks import PybricksHubBLE, PybricksHubUSB
 
         # Pick the right connection
         if args.conntype == "ssh":
@@ -185,14 +187,28 @@ async def run(self, args: argparse.Namespace):
 
             device_or_address = socket.gethostbyname(args.name)
             hub = EV3Connection(device_or_address)
+
         elif args.conntype == "ble":
             # It is a Pybricks Hub with BLE. Device name or address is given.
             print(f"Searching for {args.name or 'any hub with Pybricks service'}...")
-            device_or_address = await find_device(args.name)
+            device_or_address = await find_ble(args.name)
             hub = PybricksHubBLE(device_or_address)
 
         elif args.conntype == "usb":
-            hub = REPLHub()
+
+            def is_pybricks_usb(dev):
+                return (
+                    (dev.idVendor == 0x0694)
+                    and ((dev.idProduct == 0x0009) or (dev.idProduct == 0x0011))
+                    and dev.product.endswith("Pybricks")
+                )
+
+            device_or_address = find_usb(custom_match=is_pybricks_usb)
+
+            if device_or_address is not None:
+                hub = PybricksHubUSB(device_or_address)
+            else:
+                hub = REPLHub()
         else:
             raise ValueError(f"Unknown connection type: {args.conntype}")
 
diff --git a/pybricksdev/connections/pybricks.py b/pybricksdev/connections/pybricks.py
index 3b69b60..c5dda82 100644
--- a/pybricksdev/connections/pybricks.py
+++ b/pybricksdev/connections/pybricks.py
@@ -7,6 +7,7 @@
 import os
 import struct
 from typing import Awaitable, Callable, List, Optional, TypeVar
+from uuid import UUID
 
 import reactivex.operators as op
 import semver
@@ -17,10 +18,15 @@
 from reactivex.subject import BehaviorSubject, Subject
 from tqdm.auto import tqdm
 from tqdm.contrib.logging import logging_redirect_tqdm
+from usb.control import get_descriptor
+from usb.core import Device as USBDevice
+from usb.core import Endpoint, USBTimeoutError
+from usb.util import ENDPOINT_IN, ENDPOINT_OUT, endpoint_direction, find_descriptor
 
 from ..ble.lwp3.bytecodes import HubKind
 from ..ble.nus import NUS_RX_UUID, NUS_TX_UUID
 from ..ble.pybricks import (
+    DVC_NAME_UUID,
     FW_REV_UUID,
     PNP_ID_UUID,
     PYBRICKS_COMMAND_EVENT_UUID,
@@ -705,3 +711,120 @@ async def write_gatt_char(self, uuid: str, data, response: bool) -> None:
 
     async def start_notify(self, uuid: str, callback: Callable) -> None:
         return await self._client.start_notify(uuid, callback)
+
+
+class PybricksHubUSB(PybricksHub):
+    _device: USBDevice
+    _ep_in: Endpoint
+    _ep_out: Endpoint
+    _notify_callbacks = {}
+    _monitor_task: asyncio.Task
+
+    def __init__(self, device: USBDevice):
+        super().__init__()
+        self._device = device
+
+    async def _client_connect(self) -> bool:
+        self._device.set_configuration()
+
+        # Save input and output endpoints
+        cfg = self._device.get_active_configuration()
+        intf = cfg[(0, 0)]
+        self._ep_in = find_descriptor(
+            intf,
+            custom_match=lambda e: endpoint_direction(e.bEndpointAddress)
+            == ENDPOINT_IN,
+        )
+        self._ep_out = find_descriptor(
+            intf,
+            custom_match=lambda e: endpoint_direction(e.bEndpointAddress)
+            == ENDPOINT_OUT,
+        )
+
+        # Set write size to endpoint packet size minus length of UUID
+        self._max_write_size = self._ep_out.wMaxPacketSize - 16
+
+        # Get length of BOS descriptor
+        bos_descriptor = get_descriptor(self._device, 5, 0x0F, 0)
+        (ofst, _, bos_len, _) = struct.unpack("<BBHB", bos_descriptor)
+
+        # Get full BOS descriptor
+        bos_descriptor = get_descriptor(self._device, bos_len, 0x0F, 0)
+
+        while ofst < bos_len:
+            (len, desc_type, cap_type) = struct.unpack_from(
+                "<BBB", bos_descriptor, offset=ofst
+            )
+
+            if desc_type != 0x10:
+                logger.error("Expected Device Capability descriptor")
+                exit(1)
+
+            # Look for platform descriptors
+            if cap_type == 0x05:
+                uuid_bytes = bos_descriptor[ofst + 4 : ofst + 4 + 16]
+                uuid_str = str(UUID(bytes_le=bytes(uuid_bytes)))
+
+                if uuid_str == DVC_NAME_UUID:
+                    device_name = bytearray(bos_descriptor[ofst + 20 : ofst + len])
+                    print("Connected to hub '" + device_name.decode() + "'")
+
+                elif uuid_str == FW_REV_UUID:
+                    fw_version = bytearray(bos_descriptor[ofst + 20 : ofst + len])
+                    self.fw_version = Version(fw_version.decode())
+
+                elif uuid_str == SW_REV_UUID:
+                    self._protocol_version = bytearray(
+                        bos_descriptor[ofst + 20 : ofst + len]
+                    )
+
+                elif uuid_str == PYBRICKS_HUB_CAPABILITIES_UUID:
+                    caps = bytearray(bos_descriptor[ofst + 20 : ofst + len])
+                    (
+                        _,
+                        self._capability_flags,
+                        self._max_user_program_size,
+                    ) = unpack_hub_capabilities(caps)
+
+            ofst += len
+
+        self._monitor_task = asyncio.create_task(self._monitor_usb())
+
+        return True
+
+    async def _client_disconnect(self) -> bool:
+        self._monitor_task.cancel()
+        self._handle_disconnect()
+
+    async def read_gatt_char(self, uuid: str) -> bytearray:
+        return None
+
+    async def write_gatt_char(self, uuid: str, data, response: bool) -> None:
+        self._ep_out.write(UUID(uuid).bytes_le + data)
+        # TODO: Handle response
+
+    async def start_notify(self, uuid: str, callback: Callable) -> None:
+        self._notify_callbacks[uuid] = callback
+
+    async def _monitor_usb(self):
+        loop = asyncio.get_running_loop()
+
+        while True:
+            msg = await loop.run_in_executor(None, self._read_usb)
+
+            if msg is None:
+                continue
+
+            if len(msg) > 16:
+                uuid = str(UUID(bytes_le=bytes(msg[0:16])))
+                if uuid in self._notify_callbacks:
+                    callback = self._notify_callbacks[uuid]
+                    if callback:
+                        callback(None, bytes(msg[16:]))
+
+    def _read_usb(self):
+        try:
+            msg = self._ep_in.read(self._ep_in.wMaxPacketSize)
+            return msg
+        except USBTimeoutError:
+            return None