model_erb2.aeon

CDK2 -> pRB1
CDK4 -> pRB1
CDK6 -> pRB1

P27 -| CDK4
P21 -| CDK4
CyclinD1 -> CDK4

CyclinD1 -> CDK6

CyclinE1 -> CDK2
P27 -| CDK2
P21 -| CDK2

MEK1 -> CyclinD1
ERalpha -> CyclinD1
MYC -> CyclinD1
AKT1 -> CyclinD1

CDK4 -| P27
ERalpha -> P27
MYC -| P27
CDK2 -| P27
AKT1 -| P27

CDK4 -| P21
ERalpha -> P21
MYC -| P21
AKT1 -| P21

MYC -> CyclinE1

MEK1 -> ERalpha
AKT1 -> ERalpha

MEK1 -> MYC
ERalpha -> MYC
AKT1 -> MYC

ERBB2_3 -> AKT1
ERBB1 -> AKT1
IGF1R -> AKT1
ERBB1_3 -> AKT1
ERBB1_2 -> AKT1

ERBB2_3 -> MEK1
ERBB1 -> MEK1
IGF1R -> MEK1
ERBB1_3 -> MEK1
ERBB1_2 -> MEK1

ERBB2_3 -| IGF1R
ERalpha -> IGF1R
AKT1 -> IGF1R

ERBB2 -> ERBB2_3
ERBB3 -> ERBB2_3

ERBB1 -> ERBB1_3
ERBB3 -> ERBB1_3

ERBB1 -> ERBB1_2
ERBB2 -> ERBB1_2

EGF -> ERBB1
EGF -> ERBB2
EGF -> ERBB3