diff --git a/.github/workflows/instrumentations_1.yml b/.github/workflows/instrumentations_1.yml
index 0640c056a6..978642a7a3 100644
--- a/.github/workflows/instrumentations_1.yml
+++ b/.github/workflows/instrumentations_1.yml
@@ -25,7 +25,7 @@ jobs:
         python-version: [py38, py39, py310, py311, pypy3]
         package:
           - "urllib"
-          - "urllib3v"
+          - "urllib3"
           - "wsgi"
           - "distro"
           - "richconsole"
diff --git a/CHANGELOG.md b/CHANGELOG.md
index 653bfaec43..d1f8850790 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -7,12 +7,18 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 
 ## Unreleased
 
-### Fixed
-- Fix bootstrap when aiohttp installed ([#2299](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/2299))
+- `opentelemetry-instrumentation-celery` Allow Celery instrumentation to be installed multiple times
+  ([#2342](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/2342))
+- Align gRPC span status codes to OTEL specification
+  ([#1756](https://github.com/open-telemetry/opentelemetry-python-contrib/issues/1756))
+- `opentelemetry-instrumentation-flask` Add importlib metadata default for deprecation warning flask version
+  ([#2297](https://github.com/open-telemetry/opentelemetry-python-contrib/issues/2297))
+- Ensure all http.server.duration metrics have the same description
+  ([#2151](https://github.com/open-telemetry/opentelemetry-python-contrib/issues/2298))
 
 ## Version 1.23.0/0.44b0 (2024-02-23)
 
-- Drop support for 3.7
+- Drop uspport for 3.7
   ([#2151](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/2151))
 - `opentelemetry-resource-detector-azure` Added 10s timeout to VM Resource Detector
   ([#2119](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/2119))
diff --git a/CONTRIBUTING.md b/CONTRIBUTING.md
index 7c76634db7..0c18392bc7 100644
--- a/CONTRIBUTING.md
+++ b/CONTRIBUTING.md
@@ -13,7 +13,26 @@ on how to become a [**Member**](https://github.com/open-telemetry/community/blob
 [**Approver**](https://github.com/open-telemetry/community/blob/main/community-membership.md#approver)
 and [**Maintainer**](https://github.com/open-telemetry/community/blob/main/community-membership.md#maintainer).
 
-## Find a Buddy and get Started Quickly!
+## Index
+
+* [Find a Buddy and get Started Quickly](#find-a-buddy-and-get-started-quickly)
+* [Development](#development)
+  * [Troubleshooting](#troubleshooting)
+  * [Benchmarks](#benchmarks)
+* [Pull requests](#pull-requests)
+  * [How to Send Pull Requests](#how-to-send-pull-requests)
+  * [How to Receive Comments](#how-to-receive-comments)
+  * [How to Get PRs Reviewed](#how-to-get-prs-reviewed)
+  * [How to Get PRs Merged](#how-to-get-prs-merged)
+* [Design Choices](#design-choices)
+  * [Focus on Capabilities, Not Structure Compliance](#focus-on-capabilities-not-structure-compliance)
+* [Running Tests Locally](#running-tests-locally)
+  * [Testing against a different Core repo branch/commit](#testing-against-a-different-core-repo-branchcommit)
+* [Style Guide](#style-guide)
+* [Guideline for instrumentations](#guideline-for-instrumentations)
+* [Expectations from contributors](#expectations-from-contributors)
+
+## Find a Buddy and get Started Quickly
 
 If you are looking for someone to help you find a starting point and be a resource for your first contribution, join our
 Slack and find a buddy!
@@ -31,8 +50,8 @@ This project uses [tox](https://tox.readthedocs.io) to automate
 some aspects of development, including testing against multiple Python versions.
 To install `tox`, run:
 
-```console
-$ pip install tox
+```sh
+pip install tox
 ```
 
 You can run `tox` with the following arguments:
@@ -57,7 +76,7 @@ for more detail on available tox commands.
 
 ### Troubleshooting
 
-- Some packages may require additional system wide dependencies to be installed. For example, you may need to install `libpq-dev` to run the postgresql client libraries instrumentation tests. or `libsnappy-dev` to run the prometheus exporter tests. If you encounter a build error, please check the installation instructions for the package you are trying to run tests for.
+> Some packages may require additional system wide dependencies to be installed. For example, you may need to install `libpq-dev` to run the postgresql client libraries instrumentation tests. or `libsnappy-dev` to run the prometheus exporter tests. If you encounter a build error, please check the installation instructions for the package you are trying to run tests for.
 
 ### Benchmarks
 
@@ -94,13 +113,13 @@ pull requests (PRs).
 To create a new PR, fork the project in GitHub and clone the upstream repo:
 
 ```sh
-$ git clone https://github.com/open-telemetry/opentelemetry-python-contrib.git
+git clone https://github.com/open-telemetry/opentelemetry-python-contrib.git
 ```
 
 Add your fork as an origin:
 
 ```sh
-$ git remote add fork https://github.com/YOUR_GITHUB_USERNAME/opentelemetry-python-contrib.git
+git remote add fork https://github.com/YOUR_GITHUB_USERNAME/opentelemetry-python-contrib.git
 ```
 
 Run tests:
@@ -114,10 +133,10 @@ $ tox  # execute in the root of the repository
 Check out a new branch, make modifications and push the branch to your fork:
 
 ```sh
-$ git checkout -b feature
+git checkout -b feature
 # edit files
-$ git commit
-$ git push fork feature
+git commit
+git push fork feature
 ```
 
 Open a pull request against the main `opentelemetry-python-contrib` repo.
@@ -142,6 +161,7 @@ If you are not getting reviews, please contact the respective owners directly.
 ### How to Get PRs Merged
 
 A PR is considered to be **ready to merge** when:
+
 * It has received two approvals from [Approvers](https://github.com/open-telemetry/community/blob/main/community-membership.md#approver)
   / [Maintainers](https://github.com/open-telemetry/community/blob/main/community-membership.md#maintainer)
   (at different companies).
@@ -186,8 +206,7 @@ Some of the tox targets install packages from the [OpenTelemetry Python Core Rep
 
 CORE_REPO_SHA=c49ad57bfe35cfc69bfa863d74058ca9bec55fc3 tox
 
-The continuation integration overrides that environment variable with as per the configuration [here](https://github.com/open-telemetry/opentelemetry-python-contrib/blob/main/.github/workflows/test.yml#L9).
-
+The continuation integration overrides that environment variable with as per the configuration [here](https://github.com/open-telemetry/opentelemetry-python-contrib/blob/2518a4ac07cb62ad6587dd8f6cbb5f8663a7e179/.github/workflows/test.yml#L9).
 
 ## Style Guide
 
@@ -203,27 +222,25 @@ Below is a checklist of things to be mindful of when implementing a new instrume
 
 - Follow semantic conventions
   - The instrumentation should follow the semantic conventions defined [here](https://github.com/open-telemetry/opentelemetry-specification/tree/main/specification/semantic-conventions.md)
-- Extends from [BaseInstrumentor](https://github.com/open-telemetry/opentelemetry-python-contrib/blob/main/opentelemetry-instrumentation/src/opentelemetry/instrumentation/instrumentor.py#L26)
+- Extends from [BaseInstrumentor](https://github.com/open-telemetry/opentelemetry-python-contrib/blob/2518a4ac07cb62ad6587dd8f6cbb5f8663a7e179/opentelemetry-instrumentation/src/opentelemetry/instrumentation/instrumentor.py#L35)
 - Supports auto-instrumentation
-  - Add an entry point (ex. https://github.com/open-telemetry/opentelemetry-python-contrib/blob/f045c43affff6ff1af8fa2f7514a4fdaca97dacf/instrumentation/opentelemetry-instrumentation-requests/pyproject.toml#L44)
+  - Add an entry point (ex. <https://github.com/open-telemetry/opentelemetry-python-contrib/blob/2518a4ac07cb62ad6587dd8f6cbb5f8663a7e179/instrumentation/opentelemetry-instrumentation-requests/pyproject.toml#L44>)
   - Run `python scripts/generate_instrumentation_bootstrap.py` after adding a new instrumentation package.
 - Functionality that is common amongst other instrumentation and can be abstracted [here](https://github.com/open-telemetry/opentelemetry-python-contrib/tree/main/opentelemetry-instrumentation/src/opentelemetry/instrumentation)
 - Request/response [hooks](https://github.com/open-telemetry/opentelemetry-python-contrib/issues/408) for http instrumentations
 - `suppress_instrumentation` functionality
-  - ex. https://github.com/open-telemetry/opentelemetry-python-contrib/blob/3ec77360cb20482b08b30312a6bedc8b946e3fa1/instrumentation/opentelemetry-instrumentation-requests/src/opentelemetry/instrumentation/requests/__init__.py#L111
+  - ex. <https://github.com/open-telemetry/opentelemetry-python-contrib/blob/2518a4ac07cb62ad6587dd8f6cbb5f8663a7e179/opentelemetry-instrumentation/src/opentelemetry/instrumentation/utils.py#L191>
 - Suppress propagation functionality
   - https://github.com/open-telemetry/opentelemetry-python-contrib/issues/344 for more context
 - `exclude_urls` functionality
-  - ex. https://github.com/open-telemetry/opentelemetry-python-contrib/blob/0fcb60d2ad139f78a52edd85b1cc4e32f2e962d0/instrumentation/opentelemetry-instrumentation-flask/src/opentelemetry/instrumentation/flask/__init__.py#L91
+  - ex. <https://github.com/open-telemetry/opentelemetry-python-contrib/blob/2518a4ac07cb62ad6587dd8f6cbb5f8663a7e179/instrumentation/opentelemetry-instrumentation-flask/src/opentelemetry/instrumentation/flask/__init__.py#L327>
 - `url_filter` functionality
-  - ex. https://github.com/open-telemetry/opentelemetry-python-contrib/blob/0fcb60d2ad139f78a52edd85b1cc4e32f2e962d0/instrumentation/opentelemetry-instrumentation-aiohttp-client/src/opentelemetry/instrumentation/aiohttp_client/__init__.py#L235
+  - ex. <https://github.com/open-telemetry/opentelemetry-python-contrib/blob/2518a4ac07cb62ad6587dd8f6cbb5f8663a7e179/instrumentation/opentelemetry-instrumentation-aiohttp-client/src/opentelemetry/instrumentation/aiohttp_client/__init__.py#L268>
 - `is_recording()` optimization on non-sampled spans
-  - ex. https://github.com/open-telemetry/opentelemetry-python-contrib/blob/main/instrumentation/opentelemetry-instrumentation-requests/src/opentelemetry/instrumentation/requests/__init__.py#L133
+  - ex. <https://github.com/open-telemetry/opentelemetry-python-contrib/blob/2518a4ac07cb62ad6587dd8f6cbb5f8663a7e179/instrumentation/opentelemetry-instrumentation-requests/src/opentelemetry/instrumentation/requests/__init__.py#L234>
 - Appropriate error handling
-  - ex. https://github.com/open-telemetry/opentelemetry-python-contrib/blob/main/instrumentation/opentelemetry-instrumentation-requests/src/opentelemetry/instrumentation/requests/__init__.py#L146
-
+  - ex. <https://github.com/open-telemetry/opentelemetry-python-contrib/blob/2518a4ac07cb62ad6587dd8f6cbb5f8663a7e179/instrumentation/opentelemetry-instrumentation-requests/src/opentelemetry/instrumentation/requests/__init__.py#L220>
 
 ## Expectations from contributors
 
 OpenTelemetry is an open source community, and as such, greatly encourages contributions from anyone interested in the project. With that being said, there is a certain level of expectation from contributors even after a pull request is merged, specifically pertaining to instrumentations. The OpenTelemetry Python community expects contributors to maintain a level of support and interest in the instrumentations they contribute. This is to ensure that the instrumentation does not become stale and still functions the way the original contributor intended. Some instrumentations also pertain to libraries that the current members of the community are not so familiar with, so it is necessary to rely on the expertise of the original contributing parties.
-
diff --git a/README.md b/README.md
index 0a3d37ab3f..c315b4a876 100644
--- a/README.md
+++ b/README.md
@@ -36,11 +36,20 @@
 
 ---
 
-## OpenTelemetry Python Contrib
+# OpenTelemetry Python Contrib
 
 The Python auto-instrumentation libraries for [OpenTelemetry](https://opentelemetry.io/) (per [OTEP 0001](https://github.com/open-telemetry/oteps/blob/main/text/0001-telemetry-without-manual-instrumentation.md))
 
-### Installation
+## Index
+
+* [Installation](#installation)
+* [Releasing](#releasing)
+  * [Releasing a package as `1.0` stable](#releasing-a-package-as-10-stable)
+* [Contributing](#contributing)
+* [Running Tests Locally](#running-tests-locally)
+* [Thanks to all the people who already contributed](#thanks-to-all-the-people-who-already-contributed)
+
+## Installation
 
 This repository includes installable packages for each instrumented library. Libraries that produce telemetry data should only depend on `opentelemetry-api`,
 and defer the choice of the SDK to the application developer. Applications may
@@ -79,6 +88,7 @@ To resolve this, members of the community are encouraged to commit to becoming a
 ### Releasing a package as `1.0` stable
 
 To release a package as `1.0` stable, the package:
+
 - SHOULD have a CODEOWNER. To become one, submit an issue and explain why you meet the responsibilities found in [CODEOWNERS](.github/CODEOWNERS).
 - MUST have unit tests that cover all supported versions of the instrumented library.
   - e.g. Instrumentation packages might use different techniques to instrument different major versions of python packages
@@ -131,9 +141,8 @@ Emeritus Maintainers:
 4. Make sure you have `tox` installed. `pip install tox`.
 5. Run tests for a package. (e.g. `tox -e test-instrumentation-flask`.)
 
-### Thanks to all the people who already contributed!
+### Thanks to all the people who already contributed
 
 <a href="https://github.com/open-telemetry/opentelemetry-python-contrib/graphs/contributors">
   <img src="https://contributors-img.web.app/image?repo=open-telemetry/opentelemetry-python-contrib" />
 </a>
-
diff --git a/RELEASING.md b/RELEASING.md
index 1547cec224..256674d1b8 100644
--- a/RELEASING.md
+++ b/RELEASING.md
@@ -77,15 +77,17 @@
   * If for some reason the action failed, see [Publish failed](#publish-failed) below
 * Move stable tag
   * Run the following (TODO automate):
+
     ```bash
     git tag -d stable
     git tag stable
     git push --delete origin tagname
     git push origin stable
     ```
+
   * This will ensure the docs are pointing at the stable release.
   * To validate this worked, ensure the stable build has run successfully:
-    https://readthedocs.org/projects/opentelemetry-python/builds/.
+    <https://readthedocs.org/projects/opentelemetry-python/builds/>.
     If the build has not run automatically, it can be manually trigger via the readthedocs interface.
 
 ## Troubleshooting
@@ -98,4 +100,4 @@ If for some reason the action failed, do it manually:
 - Build distributions with `./scripts/build.sh`
 - Delete distributions we don't want to push (e.g. `testutil`)
 - Push to PyPI as `twine upload --skip-existing --verbose dist/*`
-- Double check PyPI!
\ No newline at end of file
+- Double check PyPI!
diff --git a/exporter/opentelemetry-exporter-prometheus-remote-write/proto/generate-proto-py.sh b/exporter/opentelemetry-exporter-prometheus-remote-write/proto/generate-proto-py.sh
index 3cde0bd1ac..5f6129df55 100755
--- a/exporter/opentelemetry-exporter-prometheus-remote-write/proto/generate-proto-py.sh
+++ b/exporter/opentelemetry-exporter-prometheus-remote-write/proto/generate-proto-py.sh
@@ -1,4 +1,5 @@
 #!/bin/bash
+set -e
 
 PROM_VERSION=v2.39.0
 PROTO_VERSION=v1.3.2
diff --git a/instrumentation/opentelemetry-instrumentation-aio-pika/README.rst b/instrumentation/opentelemetry-instrumentation-aio-pika/README.rst
index aa0f1a3f5c..bb5e46cf2f 100644
--- a/instrumentation/opentelemetry-instrumentation-aio-pika/README.rst
+++ b/instrumentation/opentelemetry-instrumentation-aio-pika/README.rst
@@ -18,6 +18,6 @@ Installation
 References
 ----------
 
-* `OpenTelemetry Aio-pika instrumentation <https://opentelemetry-python-contrib.readthedocs.io/en/latest/instrumentation/aio-pika/aio-pika.html>`_
+* `OpenTelemetry Aio-pika instrumentation <https://opentelemetry-python-contrib.readthedocs.io/en/latest/instrumentation/aio_pika/aio_pika.html>`_
 * `OpenTelemetry Project <https://opentelemetry.io/>`_
 * `OpenTelemetry Python Examples <https://github.com/open-telemetry/opentelemetry-python/tree/main/docs/examples>`_
diff --git a/instrumentation/opentelemetry-instrumentation-aio-pika/pyproject.toml b/instrumentation/opentelemetry-instrumentation-aio-pika/pyproject.toml
index f328eab452..e79dac2866 100644
--- a/instrumentation/opentelemetry-instrumentation-aio-pika/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-aio-pika/pyproject.toml
@@ -33,12 +33,6 @@ dependencies = [
 instruments = [
   "aio_pika >= 7.2.0, < 10.0.0",
 ]
-test = [
-  "opentelemetry-instrumentation-aio-pika[instruments]",
-  "opentelemetry-test-utils == 0.45b0.dev",
-  "pytest",
-  "wrapt >= 1.0.0, < 2.0.0",
-]
 
 [project.entry-points.opentelemetry_instrumentor]
 aio-pika = "opentelemetry.instrumentation.aio_pika:AioPikaInstrumentor"
diff --git a/instrumentation/opentelemetry-instrumentation-aio-pika/test-requirements-0.txt b/instrumentation/opentelemetry-instrumentation-aio-pika/test-requirements-0.txt
new file mode 100644
index 0000000000..c8ffea4e89
--- /dev/null
+++ b/instrumentation/opentelemetry-instrumentation-aio-pika/test-requirements-0.txt
@@ -0,0 +1,23 @@
+aio-pika==7.2.0
+aiormq==6.2.3
+asgiref==3.7.2
+attrs==23.2.0
+Deprecated==1.2.14
+idna==3.6
+importlib-metadata==6.11.0
+iniconfig==2.0.0
+multidict==6.0.5
+packaging==23.2
+pamqp==3.1.0
+pluggy==1.4.0
+py==1.11.0
+py-cpuinfo==9.0.0
+pytest==7.1.3
+pytest-benchmark==4.0.0
+tomli==2.0.1
+typing_extensions==4.9.0
+wrapt==1.16.0
+yarl==1.9.4
+zipp==3.17.0
+-e opentelemetry-instrumentation
+-e instrumentation/opentelemetry-instrumentation-aio-pika
diff --git a/instrumentation/opentelemetry-instrumentation-aio-pika/test-requirements-1.txt b/instrumentation/opentelemetry-instrumentation-aio-pika/test-requirements-1.txt
new file mode 100644
index 0000000000..1e2ea5a1e5
--- /dev/null
+++ b/instrumentation/opentelemetry-instrumentation-aio-pika/test-requirements-1.txt
@@ -0,0 +1,23 @@
+aio-pika==8.3.0
+aiormq==6.6.4
+asgiref==3.7.2
+attrs==23.2.0
+Deprecated==1.2.14
+idna==3.6
+importlib-metadata==6.11.0
+iniconfig==2.0.0
+multidict==6.0.5
+packaging==23.2
+pamqp==3.2.1
+pluggy==1.4.0
+py==1.11.0
+py-cpuinfo==9.0.0
+pytest==7.1.3
+pytest-benchmark==4.0.0
+tomli==2.0.1
+typing_extensions==4.9.0
+wrapt==1.16.0
+yarl==1.9.4
+zipp==3.17.0
+-e opentelemetry-instrumentation
+-e instrumentation/opentelemetry-instrumentation-aio-pika
diff --git a/instrumentation/opentelemetry-instrumentation-aio-pika/test-requirements-2.txt b/instrumentation/opentelemetry-instrumentation-aio-pika/test-requirements-2.txt
new file mode 100644
index 0000000000..3250c93947
--- /dev/null
+++ b/instrumentation/opentelemetry-instrumentation-aio-pika/test-requirements-2.txt
@@ -0,0 +1,23 @@
+aio-pika==9.4.0
+aiormq==6.8.0
+asgiref==3.7.2
+attrs==23.2.0
+Deprecated==1.2.14
+idna==3.6
+importlib-metadata==6.11.0
+iniconfig==2.0.0
+multidict==6.0.5
+packaging==23.2
+pamqp==3.3.0
+pluggy==1.4.0
+py==1.11.0
+py-cpuinfo==9.0.0
+pytest==7.1.3
+pytest-benchmark==4.0.0
+tomli==2.0.1
+typing_extensions==4.9.0
+wrapt==1.16.0
+yarl==1.9.4
+zipp==3.17.0
+-e opentelemetry-instrumentation
+-e instrumentation/opentelemetry-instrumentation-aio-pika
diff --git a/instrumentation/opentelemetry-instrumentation-aio-pika/tests/test_publish_decorator.py b/instrumentation/opentelemetry-instrumentation-aio-pika/tests/test_publish_decorator.py
index 41cd11d5a6..90a029531d 100644
--- a/instrumentation/opentelemetry-instrumentation-aio-pika/tests/test_publish_decorator.py
+++ b/instrumentation/opentelemetry-instrumentation-aio-pika/tests/test_publish_decorator.py
@@ -75,9 +75,7 @@ def _test_publish(self, exchange_type: Type[Exchange]):
         with mock.patch.object(
             PublishDecorator, "_get_publish_span"
         ) as mock_get_publish_span:
-            with mock.patch.object(
-                Exchange, "publish", return_value=asyncio.sleep(0)
-            ) as mock_publish:
+            with mock.patch.object(Exchange, "publish") as mock_publish:
                 decorated_publish = PublishDecorator(
                     self.tracer, exchange
                 ).decorate(mock_publish)
@@ -101,9 +99,7 @@ def _test_publish_works_with_not_recording_span(self, exchange_type):
             mocked_not_recording_span = MagicMock()
             mocked_not_recording_span.is_recording.return_value = False
             mock_get_publish_span.return_value = mocked_not_recording_span
-            with mock.patch.object(
-                Exchange, "publish", return_value=asyncio.sleep(0)
-            ) as mock_publish:
+            with mock.patch.object(Exchange, "publish") as mock_publish:
                 with mock.patch(
                     "opentelemetry.instrumentation.aio_pika.publish_decorator.propagate.inject"
                 ) as mock_inject:
@@ -158,9 +154,7 @@ def _test_publish(self, exchange_type: Type[Exchange]):
         with mock.patch.object(
             PublishDecorator, "_get_publish_span"
         ) as mock_get_publish_span:
-            with mock.patch.object(
-                Exchange, "publish", return_value=asyncio.sleep(0)
-            ) as mock_publish:
+            with mock.patch.object(Exchange, "publish") as mock_publish:
                 decorated_publish = PublishDecorator(
                     self.tracer, exchange
                 ).decorate(mock_publish)
@@ -184,9 +178,7 @@ def _test_publish_works_with_not_recording_span(self, exchange_type):
             mocked_not_recording_span = MagicMock()
             mocked_not_recording_span.is_recording.return_value = False
             mock_get_publish_span.return_value = mocked_not_recording_span
-            with mock.patch.object(
-                Exchange, "publish", return_value=asyncio.sleep(0)
-            ) as mock_publish:
+            with mock.patch.object(Exchange, "publish") as mock_publish:
                 with mock.patch(
                     "opentelemetry.instrumentation.aio_pika.publish_decorator.propagate.inject"
                 ) as mock_inject:
diff --git a/instrumentation/opentelemetry-instrumentation-aiohttp-client/pyproject.toml b/instrumentation/opentelemetry-instrumentation-aiohttp-client/pyproject.toml
index 9aac42647a..b7c0e52b7c 100644
--- a/instrumentation/opentelemetry-instrumentation-aiohttp-client/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-aiohttp-client/pyproject.toml
@@ -35,10 +35,6 @@ dependencies = [
 instruments = [
   "aiohttp ~= 3.0",
 ]
-test = [
-  "opentelemetry-instrumentation-aiohttp-client[instruments]",
-  "http-server-mock"
-]
 
 [project.entry-points.opentelemetry_instrumentor]
 aiohttp-client = "opentelemetry.instrumentation.aiohttp_client:AioHttpClientInstrumentor"
diff --git a/instrumentation/opentelemetry-instrumentation-aiohttp-client/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-aiohttp-client/test-requirements.txt
new file mode 100644
index 0000000000..b8ccfd2a50
--- /dev/null
+++ b/instrumentation/opentelemetry-instrumentation-aiohttp-client/test-requirements.txt
@@ -0,0 +1,37 @@
+aiohttp==3.9.3
+aiosignal==1.3.1
+asgiref==3.7.2
+async-timeout==4.0.3
+attrs==23.2.0
+blinker==1.7.0
+certifi==2024.2.2
+charset-normalizer==3.3.2
+click==8.1.7
+Deprecated==1.2.14
+Flask==3.0.2
+frozenlist==1.4.1
+http_server_mock==1.7
+idna==3.6
+importlib-metadata==6.11.0
+iniconfig==2.0.0
+itsdangerous==2.1.2
+Jinja2==3.1.3
+MarkupSafe==2.1.5
+multidict==6.0.5
+packaging==23.2
+pluggy==1.4.0
+py==1.11.0
+py-cpuinfo==9.0.0
+pytest==7.1.3
+pytest-benchmark==4.0.0
+requests==2.31.0
+tomli==2.0.1
+typing_extensions==4.10.0
+urllib3==2.2.1
+Werkzeug==3.0.1
+wrapt==1.16.0
+yarl==1.9.4
+zipp==3.17.0
+-e opentelemetry-instrumentation
+-e util/opentelemetry-util-http
+-e instrumentation/opentelemetry-instrumentation-aiohttp-client
diff --git a/instrumentation/opentelemetry-instrumentation-aiohttp-server/pyproject.toml b/instrumentation/opentelemetry-instrumentation-aiohttp-server/pyproject.toml
index 566f9dbb35..3ea2340d89 100644
--- a/instrumentation/opentelemetry-instrumentation-aiohttp-server/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-aiohttp-server/pyproject.toml
@@ -35,11 +35,6 @@ dependencies = [
 instruments = [
     "aiohttp ~= 3.0",
 ]
-test = [
-  "opentelemetry-instrumentation-aiohttp-server[instruments]",
-  "pytest-asyncio",
-  "pytest-aiohttp",
-]
 
 [project.entry-points.opentelemetry_instrumentor]
 aiohttp-server = "opentelemetry.instrumentation.aiohttp_server:AioHttpServerInstrumentor"
diff --git a/instrumentation/opentelemetry-instrumentation-aiohttp-server/src/opentelemetry/instrumentation/aiohttp_server/__init__.py b/instrumentation/opentelemetry-instrumentation-aiohttp-server/src/opentelemetry/instrumentation/aiohttp_server/__init__.py
index 914f005b2a..c1ab960818 100644
--- a/instrumentation/opentelemetry-instrumentation-aiohttp-server/src/opentelemetry/instrumentation/aiohttp_server/__init__.py
+++ b/instrumentation/opentelemetry-instrumentation-aiohttp-server/src/opentelemetry/instrumentation/aiohttp_server/__init__.py
@@ -207,7 +207,7 @@ async def middleware(request, handler):
     duration_histogram = meter.create_histogram(
         name=MetricInstruments.HTTP_SERVER_DURATION,
         unit="ms",
-        description="measures the duration of the inbound HTTP request",
+        description="Duration of HTTP client requests.",
     )
 
     active_requests_counter = meter.create_up_down_counter(
diff --git a/instrumentation/opentelemetry-instrumentation-aiohttp-server/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-aiohttp-server/test-requirements.txt
new file mode 100644
index 0000000000..9f6d7accce
--- /dev/null
+++ b/instrumentation/opentelemetry-instrumentation-aiohttp-server/test-requirements.txt
@@ -0,0 +1,27 @@
+aiohttp==3.9.3
+aiosignal==1.3.1
+asgiref==3.7.2
+async-timeout==4.0.3
+attrs==23.2.0
+Deprecated==1.2.14
+frozenlist==1.4.1
+idna==3.6
+importlib-metadata==6.11.0
+iniconfig==2.0.0
+multidict==6.0.5
+packaging==23.2
+pluggy==1.4.0
+py==1.11.0
+py-cpuinfo==9.0.0
+pytest==7.1.3
+pytest-aiohttp==1.0.5
+pytest-asyncio==0.23.5
+pytest-benchmark==4.0.0
+tomli==2.0.1
+typing_extensions==4.10.0
+wrapt==1.16.0
+yarl==1.9.4
+zipp==3.17.0
+-e opentelemetry-instrumentation
+-e util/opentelemetry-util-http
+-e instrumentation/opentelemetry-instrumentation-aiohttp-server
diff --git a/instrumentation/opentelemetry-instrumentation-aiopg/pyproject.toml b/instrumentation/opentelemetry-instrumentation-aiopg/pyproject.toml
index ebb88ee0ba..b6c54b658b 100644
--- a/instrumentation/opentelemetry-instrumentation-aiopg/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-aiopg/pyproject.toml
@@ -34,11 +34,6 @@ dependencies = [
 instruments = [
   "aiopg >= 0.13.0, < 2.0.0",
 ]
-test = [
-  "opentelemetry-instrumentation-aiopg[instruments]",
-  "opentelemetry-semantic-conventions == 0.45b0.dev",
-  "opentelemetry-test-utils == 0.45b0.dev",
-]
 
 [project.entry-points.opentelemetry_instrumentor]
 aiopg = "opentelemetry.instrumentation.aiopg:AiopgInstrumentor"
diff --git a/instrumentation/opentelemetry-instrumentation-aiopg/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-aiopg/test-requirements.txt
new file mode 100644
index 0000000000..2b03677f42
--- /dev/null
+++ b/instrumentation/opentelemetry-instrumentation-aiopg/test-requirements.txt
@@ -0,0 +1,22 @@
+aiopg==1.4.0
+asgiref==3.7.2
+async-timeout==4.0.3
+attrs==23.2.0
+Deprecated==1.2.14
+importlib-metadata==6.11.0
+iniconfig==2.0.0
+install==1.3.5
+packaging==23.2
+pluggy==1.4.0
+psycopg2-binary==2.9.9
+py==1.11.0
+py-cpuinfo==9.0.0
+pytest==7.1.3
+pytest-benchmark==4.0.0
+tomli==2.0.1
+typing_extensions==4.10.0
+wrapt==1.16.0
+zipp==3.17.0
+-e opentelemetry-instrumentation
+-e instrumentation/opentelemetry-instrumentation-dbapi
+-e instrumentation/opentelemetry-instrumentation-aiopg
diff --git a/instrumentation/opentelemetry-instrumentation-aiopg/tests/test_aiopg_integration.py b/instrumentation/opentelemetry-instrumentation-aiopg/tests/test_aiopg_integration.py
index c6d00a51fe..fb76bd0f38 100644
--- a/instrumentation/opentelemetry-instrumentation-aiopg/tests/test_aiopg_integration.py
+++ b/instrumentation/opentelemetry-instrumentation-aiopg/tests/test_aiopg_integration.py
@@ -76,7 +76,7 @@ def test_instrumentor_connect(self):
         cnx = async_call(aiopg.connect(database="test"))
         cursor = async_call(cnx.cursor())
         query = "SELECT * FROM test"
-        cursor.execute(query)
+        async_call(cursor.execute(query))
 
         spans_list = self.memory_exporter.get_finished_spans()
         self.assertEqual(len(spans_list), 1)
@@ -127,7 +127,7 @@ def test_instrumentor_create_pool(self):
         cnx = async_call(pool.acquire())
         cursor = async_call(cnx.cursor())
         query = "SELECT * FROM test"
-        cursor.execute(query)
+        async_call(cursor.execute(query))
 
         spans_list = self.memory_exporter.get_finished_spans()
         self.assertEqual(len(spans_list), 1)
diff --git a/instrumentation/opentelemetry-instrumentation-asgi/pyproject.toml b/instrumentation/opentelemetry-instrumentation-asgi/pyproject.toml
index d642a07e48..81c83b07e9 100644
--- a/instrumentation/opentelemetry-instrumentation-asgi/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-asgi/pyproject.toml
@@ -35,10 +35,6 @@ dependencies = [
 instruments = [
   "asgiref ~= 3.0",
 ]
-test = [
-  "opentelemetry-instrumentation-asgi[instruments]",
-  "opentelemetry-test-utils == 0.45b0.dev",
-]
 
 [project.urls]
 Homepage = "https://github.com/open-telemetry/opentelemetry-python-contrib/tree/main/instrumentation/opentelemetry-instrumentation-asgi"
diff --git a/instrumentation/opentelemetry-instrumentation-asgi/src/opentelemetry/instrumentation/asgi/__init__.py b/instrumentation/opentelemetry-instrumentation-asgi/src/opentelemetry/instrumentation/asgi/__init__.py
index dba7414cb1..d179f4fafa 100644
--- a/instrumentation/opentelemetry-instrumentation-asgi/src/opentelemetry/instrumentation/asgi/__init__.py
+++ b/instrumentation/opentelemetry-instrumentation-asgi/src/opentelemetry/instrumentation/asgi/__init__.py
@@ -492,7 +492,7 @@ def __init__(
         self.duration_histogram = self.meter.create_histogram(
             name=MetricInstruments.HTTP_SERVER_DURATION,
             unit="ms",
-            description="measures the duration of the inbound HTTP request",
+            description="Duration of HTTP client requests.",
         )
         self.server_response_size_histogram = self.meter.create_histogram(
             name=MetricInstruments.HTTP_SERVER_RESPONSE_SIZE,
diff --git a/instrumentation/opentelemetry-instrumentation-asgi/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-asgi/test-requirements.txt
new file mode 100644
index 0000000000..f3ee9764cf
--- /dev/null
+++ b/instrumentation/opentelemetry-instrumentation-asgi/test-requirements.txt
@@ -0,0 +1,18 @@
+asgiref==3.7.2
+attrs==23.2.0
+Deprecated==1.2.14
+importlib-metadata==6.11.0
+iniconfig==2.0.0
+packaging==23.2
+pluggy==1.4.0
+py==1.11.0
+py-cpuinfo==9.0.0
+pytest==7.1.3
+pytest-benchmark==4.0.0
+tomli==2.0.1
+typing_extensions==4.9.0
+wrapt==1.16.0
+zipp==3.17.0
+-e opentelemetry-instrumentation
+-e util/opentelemetry-util-http
+-e instrumentation/opentelemetry-instrumentation-asgi
diff --git a/instrumentation/opentelemetry-instrumentation-asyncio/pyproject.toml b/instrumentation/opentelemetry-instrumentation-asyncio/pyproject.toml
index 358fbefeb4..5354ea3cb4 100644
--- a/instrumentation/opentelemetry-instrumentation-asyncio/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-asyncio/pyproject.toml
@@ -33,12 +33,6 @@ dependencies = [
 
 [project.optional-dependencies]
 instruments = []
-test = [
-  "opentelemetry-instrumentation-asyncio[instruments]",
-  "pytest",
-  "wrapt >= 1.0.0, < 2.0.0",
-  "pytest-asyncio",
-]
 
 [project.entry-points.opentelemetry_instrumentor]
 asyncio = "opentelemetry.instrumentation.asyncio:AsyncioInstrumentor"
diff --git a/instrumentation/opentelemetry-instrumentation-asyncio/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-asyncio/test-requirements.txt
new file mode 100644
index 0000000000..14f724888b
--- /dev/null
+++ b/instrumentation/opentelemetry-instrumentation-asyncio/test-requirements.txt
@@ -0,0 +1,18 @@
+asgiref==3.7.2
+attrs==23.2.0
+Deprecated==1.2.14
+importlib-metadata==6.11.0
+iniconfig==2.0.0
+packaging==23.2
+pluggy==1.4.0
+py==1.11.0
+py-cpuinfo==9.0.0
+pytest==7.1.3
+pytest-asyncio==0.23.5
+pytest-benchmark==4.0.0
+tomli==2.0.1
+typing_extensions==4.9.0
+wrapt==1.16.0
+zipp==3.17.0
+-e opentelemetry-instrumentation
+-e instrumentation/opentelemetry-instrumentation-asyncio
diff --git a/instrumentation/opentelemetry-instrumentation-celery/src/opentelemetry/instrumentation/celery/__init__.py b/instrumentation/opentelemetry-instrumentation-celery/src/opentelemetry/instrumentation/celery/__init__.py
index 94cac68b70..10ccca1270 100644
--- a/instrumentation/opentelemetry-instrumentation-celery/src/opentelemetry/instrumentation/celery/__init__.py
+++ b/instrumentation/opentelemetry-instrumentation-celery/src/opentelemetry/instrumentation/celery/__init__.py
@@ -113,10 +113,8 @@ def keys(self, carrier):
 
 
 class CeleryInstrumentor(BaseInstrumentor):
-    def __init__(self):
-        super().__init__()
-        self.metrics = None
-        self.task_id_to_start_time = {}
+    metrics = None
+    task_id_to_start_time = {}
 
     def instrumentation_dependencies(self) -> Collection[str]:
         return _instruments
diff --git a/instrumentation/opentelemetry-instrumentation-celery/tests/test_duplicate.py b/instrumentation/opentelemetry-instrumentation-celery/tests/test_duplicate.py
new file mode 100644
index 0000000000..ab1f7804cf
--- /dev/null
+++ b/instrumentation/opentelemetry-instrumentation-celery/tests/test_duplicate.py
@@ -0,0 +1,30 @@
+# Copyright The OpenTelemetry Authors
+#
+# Licensed under the Apache License, Version 2.0 (the "License");
+# you may not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#
+#     http://www.apache.org/licenses/LICENSE-2.0
+#
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+
+import unittest
+
+from opentelemetry.instrumentation.celery import CeleryInstrumentor
+
+
+class TestUtils(unittest.TestCase):
+    def test_duplicate_instrumentaion(self):
+        first = CeleryInstrumentor()
+        first.instrument()
+        second = CeleryInstrumentor()
+        second.instrument()
+        CeleryInstrumentor().uninstrument()
+        self.assertIsNotNone(first.metrics)
+        self.assertIsNotNone(second.metrics)
+        self.assertEqual(first.task_id_to_start_time, {})
+        self.assertEqual(second.task_id_to_start_time, {})
diff --git a/instrumentation/opentelemetry-instrumentation-django/pyproject.toml b/instrumentation/opentelemetry-instrumentation-django/pyproject.toml
index 50cc227e44..65be04cb69 100644
--- a/instrumentation/opentelemetry-instrumentation-django/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-django/pyproject.toml
@@ -38,10 +38,6 @@ asgi = [
 instruments = [
   "django >= 1.10",
 ]
-test = [
-  "opentelemetry-instrumentation-django[instruments]",
-  "opentelemetry-test-utils == 0.45b0.dev",
-]
 
 [project.entry-points.opentelemetry_instrumentor]
 django = "opentelemetry.instrumentation.django:DjangoInstrumentor"
diff --git a/instrumentation/opentelemetry-instrumentation-django/src/opentelemetry/instrumentation/django/__init__.py b/instrumentation/opentelemetry-instrumentation-django/src/opentelemetry/instrumentation/django/__init__.py
index 583f1adeb6..37ac760283 100644
--- a/instrumentation/opentelemetry-instrumentation-django/src/opentelemetry/instrumentation/django/__init__.py
+++ b/instrumentation/opentelemetry-instrumentation-django/src/opentelemetry/instrumentation/django/__init__.py
@@ -322,7 +322,7 @@ def _instrument(self, **kwargs):
         _DjangoMiddleware._duration_histogram = meter.create_histogram(
             name=MetricInstruments.HTTP_SERVER_DURATION,
             unit="ms",
-            description="measures the duration of the inbound http request",
+            description="Duration of HTTP client requests.",
         )
         _DjangoMiddleware._active_request_counter = meter.create_up_down_counter(
             name=MetricInstruments.HTTP_SERVER_ACTIVE_REQUESTS,
diff --git a/instrumentation/opentelemetry-instrumentation-django/test-requirements-0.txt b/instrumentation/opentelemetry-instrumentation-django/test-requirements-0.txt
new file mode 100644
index 0000000000..6dce957000
--- /dev/null
+++ b/instrumentation/opentelemetry-instrumentation-django/test-requirements-0.txt
@@ -0,0 +1,22 @@
+asgiref==3.7.2
+attrs==23.2.0
+Deprecated==1.2.14
+Django==2.2.28
+importlib-metadata==6.11.0
+iniconfig==2.0.0
+packaging==23.2
+pluggy==1.4.0
+py==1.11.0
+py-cpuinfo==9.0.0
+pytest==7.1.3
+pytest-benchmark==4.0.0
+pytz==2024.1
+sqlparse==0.4.4
+tomli==2.0.1
+typing_extensions==4.10.0
+wrapt==1.16.0
+zipp==3.17.0
+-e opentelemetry-instrumentation
+-e instrumentation/opentelemetry-instrumentation-wsgi
+-e util/opentelemetry-util-http
+-e instrumentation/opentelemetry-instrumentation-django
diff --git a/instrumentation/opentelemetry-instrumentation-django/test-requirements-1.txt b/instrumentation/opentelemetry-instrumentation-django/test-requirements-1.txt
new file mode 100644
index 0000000000..116dc015ec
--- /dev/null
+++ b/instrumentation/opentelemetry-instrumentation-django/test-requirements-1.txt
@@ -0,0 +1,23 @@
+asgiref==3.7.2
+attrs==23.2.0
+Deprecated==1.2.14
+Django==3.2.24
+importlib-metadata==6.11.0
+iniconfig==2.0.0
+packaging==23.2
+pluggy==1.4.0
+py==1.11.0
+py-cpuinfo==9.0.0
+pytest==7.1.3
+pytest-benchmark==4.0.0
+pytz==2024.1
+sqlparse==0.4.4
+tomli==2.0.1
+typing_extensions==4.10.0
+wrapt==1.16.0
+zipp==3.17.0
+-e opentelemetry-instrumentation
+-e instrumentation/opentelemetry-instrumentation-wsgi
+-e instrumentation/opentelemetry-instrumentation-asgi
+-e util/opentelemetry-util-http
+-e instrumentation/opentelemetry-instrumentation-django
diff --git a/instrumentation/opentelemetry-instrumentation-django/test-requirements-2.txt b/instrumentation/opentelemetry-instrumentation-django/test-requirements-2.txt
new file mode 100644
index 0000000000..ac3b40e16b
--- /dev/null
+++ b/instrumentation/opentelemetry-instrumentation-django/test-requirements-2.txt
@@ -0,0 +1,23 @@
+asgiref==3.7.2
+attrs==23.2.0
+backports.zoneinfo==0.2.1
+Deprecated==1.2.14
+Django==4.2.10
+importlib-metadata==6.11.0
+iniconfig==2.0.0
+packaging==23.2
+pluggy==1.4.0
+py==1.11.0
+py-cpuinfo==9.0.0
+pytest==7.1.3
+pytest-benchmark==4.0.0
+sqlparse==0.4.4
+tomli==2.0.1
+typing_extensions==4.10.0
+wrapt==1.16.0
+zipp==3.17.0
+-e opentelemetry-instrumentation
+-e instrumentation/opentelemetry-instrumentation-wsgi
+-e instrumentation/opentelemetry-instrumentation-asgi
+-e util/opentelemetry-util-http
+-e instrumentation/opentelemetry-instrumentation-django
diff --git a/instrumentation/opentelemetry-instrumentation-django/test-requirements-3.txt b/instrumentation/opentelemetry-instrumentation-django/test-requirements-3.txt
new file mode 100644
index 0000000000..3bb32c4c6b
--- /dev/null
+++ b/instrumentation/opentelemetry-instrumentation-django/test-requirements-3.txt
@@ -0,0 +1,22 @@
+asgiref==3.7.2
+attrs==23.2.0
+Deprecated==1.2.14
+Django==4.2.10
+importlib-metadata==6.11.0
+iniconfig==2.0.0
+packaging==23.2
+pluggy==1.4.0
+py==1.11.0
+py-cpuinfo==9.0.0
+pytest==7.1.3
+pytest-benchmark==4.0.0
+sqlparse==0.4.4
+tomli==2.0.1
+typing_extensions==4.10.0
+wrapt==1.16.0
+zipp==3.17.0
+-e opentelemetry-instrumentation
+-e instrumentation/opentelemetry-instrumentation-wsgi
+-e instrumentation/opentelemetry-instrumentation-asgi
+-e util/opentelemetry-util-http
+-e instrumentation/opentelemetry-instrumentation-django
diff --git a/instrumentation/opentelemetry-instrumentation-elasticsearch/pyproject.toml b/instrumentation/opentelemetry-instrumentation-elasticsearch/pyproject.toml
index c716769f5c..987cfb17c1 100644
--- a/instrumentation/opentelemetry-instrumentation-elasticsearch/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-elasticsearch/pyproject.toml
@@ -34,11 +34,6 @@ dependencies = [
 instruments = [
   "elasticsearch >= 2.0",
 ]
-test = [
-  "opentelemetry-instrumentation-elasticsearch[instruments]",
-  "elasticsearch-dsl >= 2.0",
-  "opentelemetry-test-utils == 0.45b0.dev",
-]
 
 [project.entry-points.opentelemetry_instrumentor]
 elasticsearch = "opentelemetry.instrumentation.elasticsearch:ElasticsearchInstrumentor"
diff --git a/instrumentation/opentelemetry-instrumentation-elasticsearch/test-requirements-0.txt b/instrumentation/opentelemetry-instrumentation-elasticsearch/test-requirements-0.txt
new file mode 100644
index 0000000000..216d1c0b02
--- /dev/null
+++ b/instrumentation/opentelemetry-instrumentation-elasticsearch/test-requirements-0.txt
@@ -0,0 +1,22 @@
+asgiref==3.7.2
+attrs==23.2.0
+Deprecated==1.2.14
+elasticsearch==2.4.1
+elasticsearch-dsl==2.2.0
+importlib-metadata==6.11.0
+iniconfig==2.0.0
+packaging==23.2
+pluggy==1.4.0
+py==1.11.0
+py-cpuinfo==9.0.0
+pytest==7.1.3
+pytest-benchmark==4.0.0
+python-dateutil==2.8.2
+six==1.16.0
+tomli==2.0.1
+typing_extensions==4.10.0
+urllib3==1.26.18
+wrapt==1.16.0
+zipp==3.17.0
+-e opentelemetry-instrumentation
+-e instrumentation/opentelemetry-instrumentation-elasticsearch
diff --git a/instrumentation/opentelemetry-instrumentation-elasticsearch/test-requirements-1.txt b/instrumentation/opentelemetry-instrumentation-elasticsearch/test-requirements-1.txt
new file mode 100644
index 0000000000..2c51c87508
--- /dev/null
+++ b/instrumentation/opentelemetry-instrumentation-elasticsearch/test-requirements-1.txt
@@ -0,0 +1,22 @@
+asgiref==3.7.2
+attrs==23.2.0
+Deprecated==1.2.14
+elasticsearch==5.5.3
+elasticsearch-dsl==5.4.0
+importlib-metadata==6.11.0
+iniconfig==2.0.0
+packaging==23.2
+pluggy==1.4.0
+py==1.11.0
+py-cpuinfo==9.0.0
+pytest==7.1.3
+pytest-benchmark==4.0.0
+python-dateutil==2.8.2
+six==1.16.0
+tomli==2.0.1
+typing_extensions==4.10.0
+urllib3==2.2.1
+wrapt==1.16.0
+zipp==3.17.0
+-e opentelemetry-instrumentation
+-e instrumentation/opentelemetry-instrumentation-elasticsearch
diff --git a/instrumentation/opentelemetry-instrumentation-elasticsearch/test-requirements-2.txt b/instrumentation/opentelemetry-instrumentation-elasticsearch/test-requirements-2.txt
new file mode 100644
index 0000000000..4bd1d0d318
--- /dev/null
+++ b/instrumentation/opentelemetry-instrumentation-elasticsearch/test-requirements-2.txt
@@ -0,0 +1,22 @@
+asgiref==3.7.2
+attrs==23.2.0
+Deprecated==1.2.14
+elasticsearch==6.8.2
+elasticsearch-dsl==6.4.0
+importlib-metadata==6.11.0
+iniconfig==2.0.0
+packaging==23.2
+pluggy==1.4.0
+py==1.11.0
+py-cpuinfo==9.0.0
+pytest==7.1.3
+pytest-benchmark==4.0.0
+python-dateutil==2.8.2
+six==1.16.0
+tomli==2.0.1
+typing_extensions==4.10.0
+urllib3==2.2.1
+wrapt==1.16.0
+zipp==3.17.0
+-e opentelemetry-instrumentation
+-e instrumentation/opentelemetry-instrumentation-elasticsearch
diff --git a/instrumentation/opentelemetry-instrumentation-falcon/pyproject.toml b/instrumentation/opentelemetry-instrumentation-falcon/pyproject.toml
index 1e4b5e5254..dab9534bf9 100644
--- a/instrumentation/opentelemetry-instrumentation-falcon/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-falcon/pyproject.toml
@@ -36,10 +36,6 @@ dependencies = [
 instruments = [
   "falcon >= 1.4.1, < 3.1.2",
 ]
-test = [
-  "opentelemetry-instrumentation-falcon[instruments]",
-  "opentelemetry-test-utils == 0.45b0.dev",
-]
 
 [project.entry-points.opentelemetry_instrumentor]
 falcon = "opentelemetry.instrumentation.falcon:FalconInstrumentor"
diff --git a/instrumentation/opentelemetry-instrumentation-falcon/src/opentelemetry/instrumentation/falcon/__init__.py b/instrumentation/opentelemetry-instrumentation-falcon/src/opentelemetry/instrumentation/falcon/__init__.py
index d6cf8249a4..06a550cf3f 100644
--- a/instrumentation/opentelemetry-instrumentation-falcon/src/opentelemetry/instrumentation/falcon/__init__.py
+++ b/instrumentation/opentelemetry-instrumentation-falcon/src/opentelemetry/instrumentation/falcon/__init__.py
@@ -268,7 +268,7 @@ def __init__(self, *args, **kwargs):
         self.duration_histogram = self._otel_meter.create_histogram(
             name=MetricInstruments.HTTP_SERVER_DURATION,
             unit="ms",
-            description="measures the duration of the inbound HTTP request",
+            description="Duration of HTTP client requests.",
         )
         self.active_requests_counter = self._otel_meter.create_up_down_counter(
             name=MetricInstruments.HTTP_SERVER_ACTIVE_REQUESTS,
diff --git a/instrumentation/opentelemetry-instrumentation-falcon/test-requirements-0.txt b/instrumentation/opentelemetry-instrumentation-falcon/test-requirements-0.txt
new file mode 100644
index 0000000000..31c7f1d7c8
--- /dev/null
+++ b/instrumentation/opentelemetry-instrumentation-falcon/test-requirements-0.txt
@@ -0,0 +1,22 @@
+asgiref==3.7.2
+attrs==23.2.0
+Deprecated==1.2.14
+falcon==1.4.1
+importlib-metadata==6.11.0
+iniconfig==2.0.0
+packaging==23.2
+pluggy==1.4.0
+py==1.11.0
+py-cpuinfo==9.0.0
+pytest==7.1.3
+pytest-benchmark==4.0.0
+python-mimeparse==1.6.0
+six==1.16.0
+tomli==2.0.1
+typing_extensions==4.10.0
+wrapt==1.16.0
+zipp==3.17.0
+-e opentelemetry-instrumentation
+-e instrumentation/opentelemetry-instrumentation-wsgi
+-e util/opentelemetry-util-http
+-e instrumentation/opentelemetry-instrumentation-falcon
diff --git a/instrumentation/opentelemetry-instrumentation-falcon/test-requirements-1.txt b/instrumentation/opentelemetry-instrumentation-falcon/test-requirements-1.txt
new file mode 100644
index 0000000000..ad476d7c22
--- /dev/null
+++ b/instrumentation/opentelemetry-instrumentation-falcon/test-requirements-1.txt
@@ -0,0 +1,20 @@
+asgiref==3.7.2
+attrs==23.2.0
+Deprecated==1.2.14
+falcon==2.0.0
+importlib-metadata==6.11.0
+iniconfig==2.0.0
+packaging==23.2
+pluggy==1.4.0
+py==1.11.0
+py-cpuinfo==9.0.0
+pytest==7.1.3
+pytest-benchmark==4.0.0
+tomli==2.0.1
+typing_extensions==4.10.0
+wrapt==1.16.0
+zipp==3.17.0
+-e opentelemetry-instrumentation
+-e instrumentation/opentelemetry-instrumentation-wsgi
+-e util/opentelemetry-util-http
+-e instrumentation/opentelemetry-instrumentation-falcon
diff --git a/instrumentation/opentelemetry-instrumentation-falcon/test-requirements-2.txt b/instrumentation/opentelemetry-instrumentation-falcon/test-requirements-2.txt
new file mode 100644
index 0000000000..6c5c3e8ac9
--- /dev/null
+++ b/instrumentation/opentelemetry-instrumentation-falcon/test-requirements-2.txt
@@ -0,0 +1,20 @@
+asgiref==3.7.2
+attrs==23.2.0
+Deprecated==1.2.14
+falcon==3.1.1
+importlib-metadata==6.11.0
+iniconfig==2.0.0
+packaging==23.2
+pluggy==1.4.0
+py==1.11.0
+py-cpuinfo==9.0.0
+pytest==7.1.3
+pytest-benchmark==4.0.0
+tomli==2.0.1
+typing_extensions==4.10.0
+wrapt==1.16.0
+zipp==3.17.0
+-e opentelemetry-instrumentation
+-e instrumentation/opentelemetry-instrumentation-wsgi
+-e util/opentelemetry-util-http
+-e instrumentation/opentelemetry-instrumentation-falcon
diff --git a/instrumentation/opentelemetry-instrumentation-fastapi/pyproject.toml b/instrumentation/opentelemetry-instrumentation-fastapi/pyproject.toml
index 4df6d3760c..89f1c77e43 100644
--- a/instrumentation/opentelemetry-instrumentation-fastapi/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-fastapi/pyproject.toml
@@ -35,12 +35,6 @@ dependencies = [
 instruments = [
   "fastapi ~= 0.58",
 ]
-test = [
-  "opentelemetry-instrumentation-fastapi[instruments]",
-  "opentelemetry-test-utils == 0.45b0.dev",
-  "requests ~= 2.23", # needed for testclient
-  "httpx ~= 0.22", # needed for testclient
-]
 
 [project.entry-points.opentelemetry_instrumentor]
 fastapi = "opentelemetry.instrumentation.fastapi:FastAPIInstrumentor"
diff --git a/instrumentation/opentelemetry-instrumentation-fastapi/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-fastapi/test-requirements.txt
new file mode 100644
index 0000000000..8d7bf3ad78
--- /dev/null
+++ b/instrumentation/opentelemetry-instrumentation-fastapi/test-requirements.txt
@@ -0,0 +1,35 @@
+annotated-types==0.6.0
+anyio==4.3.0
+asgiref==3.7.2
+attrs==23.2.0
+certifi==2024.2.2
+charset-normalizer==3.3.2
+Deprecated==1.2.14
+exceptiongroup==1.2.0
+fastapi==0.109.2
+h11==0.14.0
+httpcore==1.0.4
+httpx==0.27.0
+idna==3.6
+importlib-metadata==6.11.0
+iniconfig==2.0.0
+packaging==23.2
+pluggy==1.4.0
+py==1.11.0
+py-cpuinfo==9.0.0
+pydantic==2.6.2
+pydantic_core==2.16.3
+pytest==7.1.3
+pytest-benchmark==4.0.0
+requests==2.31.0
+sniffio==1.3.0
+starlette==0.36.3
+tomli==2.0.1
+typing_extensions==4.9.0
+urllib3==2.2.1
+wrapt==1.16.0
+zipp==3.17.0
+-e opentelemetry-instrumentation
+-e instrumentation/opentelemetry-instrumentation-asgi
+-e util/opentelemetry-util-http
+-e instrumentation/opentelemetry-instrumentation-fastapi
diff --git a/instrumentation/opentelemetry-instrumentation-flask/pyproject.toml b/instrumentation/opentelemetry-instrumentation-flask/pyproject.toml
index ca26f4c860..8e0dd1f858 100644
--- a/instrumentation/opentelemetry-instrumentation-flask/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-flask/pyproject.toml
@@ -30,17 +30,13 @@ dependencies = [
   "opentelemetry-semantic-conventions == 0.45b0.dev",
   "opentelemetry-util-http == 0.45b0.dev",
   "packaging >= 21.0",
+  "importlib-metadata >= 4.0",
 ]
 
 [project.optional-dependencies]
 instruments = [
   "flask >= 1.0",
 ]
-test = [
-  "opentelemetry-instrumentation-flask[instruments]",
-  "markupsafe==2.1.2",
-  "opentelemetry-test-utils == 0.45b0.dev",
-]
 
 [project.entry-points.opentelemetry_instrumentor]
 flask = "opentelemetry.instrumentation.flask:FlaskInstrumentor"
diff --git a/instrumentation/opentelemetry-instrumentation-flask/src/opentelemetry/instrumentation/flask/__init__.py b/instrumentation/opentelemetry-instrumentation-flask/src/opentelemetry/instrumentation/flask/__init__.py
index 5e81cc5abe..ba1031655e 100644
--- a/instrumentation/opentelemetry-instrumentation-flask/src/opentelemetry/instrumentation/flask/__init__.py
+++ b/instrumentation/opentelemetry-instrumentation-flask/src/opentelemetry/instrumentation/flask/__init__.py
@@ -245,22 +245,13 @@ def response_hook(span: Span, status: str, response_headers: List):
 from typing import Collection
 
 import flask
+import importlib_metadata as metadata
 from packaging import version as package_version
 
 import opentelemetry.instrumentation.wsgi as otel_wsgi
 from opentelemetry import context, trace
 from opentelemetry.instrumentation.flask.package import _instruments
 from opentelemetry.instrumentation.flask.version import __version__
-
-try:
-    flask_version = flask.__version__
-except AttributeError:
-    try:
-        from importlib import metadata
-    except ImportError:
-        import importlib_metadata as metadata
-    flask_version = metadata.version("flask")
-
 from opentelemetry.instrumentation.instrumentor import BaseInstrumentor
 from opentelemetry.instrumentation.propagators import (
     get_global_response_propagator,
@@ -281,6 +272,8 @@ def response_hook(span: Span, status: str, response_headers: List):
 
 _excluded_urls_from_env = get_excluded_urls("FLASK")
 
+flask_version = metadata.version("flask")
+
 if package_version.parse(flask_version) >= package_version.parse("2.2.0"):
 
     def _request_ctx_ref() -> weakref.ReferenceType:
@@ -513,7 +506,7 @@ def __init__(self, *args, **kwargs):
         duration_histogram = meter.create_histogram(
             name=MetricInstruments.HTTP_SERVER_DURATION,
             unit="ms",
-            description="measures the duration of the inbound HTTP request",
+            description="Duration of HTTP client requests.",
         )
         active_requests_counter = meter.create_up_down_counter(
             name=MetricInstruments.HTTP_SERVER_ACTIVE_REQUESTS,
@@ -619,7 +612,7 @@ def instrument_app(
             duration_histogram = meter.create_histogram(
                 name=MetricInstruments.HTTP_SERVER_DURATION,
                 unit="ms",
-                description="measures the duration of the inbound HTTP request",
+                description="Duration of HTTP client requests.",
             )
             active_requests_counter = meter.create_up_down_counter(
                 name=MetricInstruments.HTTP_SERVER_ACTIVE_REQUESTS,
diff --git a/instrumentation/opentelemetry-instrumentation-flask/test-requirements-0.txt b/instrumentation/opentelemetry-instrumentation-flask/test-requirements-0.txt
new file mode 100644
index 0000000000..fbefeebdb4
--- /dev/null
+++ b/instrumentation/opentelemetry-instrumentation-flask/test-requirements-0.txt
@@ -0,0 +1,25 @@
+asgiref==3.7.2
+attrs==23.2.0
+click==8.1.7
+Deprecated==1.2.14
+Flask==2.1.3
+importlib-metadata==6.11.0
+iniconfig==2.0.0
+itsdangerous==2.1.2
+Jinja2==3.1.3
+MarkupSafe==2.1.2
+packaging==23.2
+pluggy==1.4.0
+py==1.11.0
+py-cpuinfo==9.0.0
+pytest==7.1.3
+pytest-benchmark==4.0.0
+tomli==2.0.1
+typing_extensions==4.9.0
+Werkzeug==2.3.8
+wrapt==1.16.0
+zipp==3.17.0
+-e opentelemetry-instrumentation
+-e instrumentation/opentelemetry-instrumentation-wsgi
+-e util/opentelemetry-util-http
+-e instrumentation/opentelemetry-instrumentation-flask
diff --git a/instrumentation/opentelemetry-instrumentation-flask/test-requirements-1.txt b/instrumentation/opentelemetry-instrumentation-flask/test-requirements-1.txt
new file mode 100644
index 0000000000..41583ad7f9
--- /dev/null
+++ b/instrumentation/opentelemetry-instrumentation-flask/test-requirements-1.txt
@@ -0,0 +1,25 @@
+asgiref==3.7.2
+attrs==23.2.0
+click==8.1.7
+Deprecated==1.2.14
+Flask==2.2.0
+importlib-metadata==6.11.0
+iniconfig==2.0.0
+itsdangerous==2.1.2
+Jinja2==3.1.3
+MarkupSafe==2.1.2
+packaging==23.2
+pluggy==1.4.0
+py==1.11.0
+py-cpuinfo==9.0.0
+pytest==7.1.3
+pytest-benchmark==4.0.0
+tomli==2.0.1
+typing_extensions==4.9.0
+Werkzeug==2.3.8
+wrapt==1.16.0
+zipp==3.17.0
+-e opentelemetry-instrumentation
+-e instrumentation/opentelemetry-instrumentation-wsgi
+-e util/opentelemetry-util-http
+-e instrumentation/opentelemetry-instrumentation-flask
diff --git a/instrumentation/opentelemetry-instrumentation-flask/test-requirements-2.txt b/instrumentation/opentelemetry-instrumentation-flask/test-requirements-2.txt
new file mode 100644
index 0000000000..3a89328861
--- /dev/null
+++ b/instrumentation/opentelemetry-instrumentation-flask/test-requirements-2.txt
@@ -0,0 +1,26 @@
+asgiref==3.7.2
+attrs==23.2.0
+blinker==1.7.0
+click==8.1.7
+Deprecated==1.2.14
+Flask==3.0.2
+importlib-metadata==6.11.0
+iniconfig==2.0.0
+itsdangerous==2.1.2
+Jinja2==3.1.3
+MarkupSafe==2.1.2
+packaging==23.2
+pluggy==1.4.0
+py==1.11.0
+py-cpuinfo==9.0.0
+pytest==7.1.3
+pytest-benchmark==4.0.0
+tomli==2.0.1
+typing_extensions==4.9.0
+Werkzeug==3.0.1
+wrapt==1.16.0
+zipp==3.17.0
+-e opentelemetry-instrumentation
+-e instrumentation/opentelemetry-instrumentation-wsgi
+-e util/opentelemetry-util-http
+-e instrumentation/opentelemetry-instrumentation-flask
diff --git a/instrumentation/opentelemetry-instrumentation-grpc/src/opentelemetry/instrumentation/grpc/_aio_server.py b/instrumentation/opentelemetry-instrumentation-grpc/src/opentelemetry/instrumentation/grpc/_aio_server.py
index 0db4c36edf..ba255ef3bf 100644
--- a/instrumentation/opentelemetry-instrumentation-grpc/src/opentelemetry/instrumentation/grpc/_aio_server.py
+++ b/instrumentation/opentelemetry-instrumentation-grpc/src/opentelemetry/instrumentation/grpc/_aio_server.py
@@ -17,9 +17,9 @@
 import wrapt
 
 from opentelemetry.semconv.trace import SpanAttributes
-from opentelemetry.trace.status import Status, StatusCode
 
 from ._server import OpenTelemetryServerInterceptor, _wrap_rpc_behavior
+from ._utilities import _server_status
 
 
 # pylint:disable=abstract-method
@@ -36,12 +36,8 @@ async def abort(self, code, details="", trailing_metadata=tuple()):
         self._self_active_span.set_attribute(
             SpanAttributes.RPC_GRPC_STATUS_CODE, code.value[0]
         )
-        self._self_active_span.set_status(
-            Status(
-                status_code=StatusCode.ERROR,
-                description=f"{code}:{details}",
-            )
-        )
+        status = _server_status(code, details)
+        self._self_active_span.set_status(status)
         return await self.__wrapped__.abort(code, details, trailing_metadata)
 
     def set_code(self, code):
@@ -51,23 +47,15 @@ def set_code(self, code):
             SpanAttributes.RPC_GRPC_STATUS_CODE, code.value[0]
         )
         if code != grpc.StatusCode.OK:
-            self._self_active_span.set_status(
-                Status(
-                    status_code=StatusCode.ERROR,
-                    description=f"{code}:{details}",
-                )
-            )
+            status = _server_status(code, details)
+            self._self_active_span.set_status(status)
         return self.__wrapped__.set_code(code)
 
     def set_details(self, details):
         self._self_details = details
         if self._self_code != grpc.StatusCode.OK:
-            self._self_active_span.set_status(
-                Status(
-                    status_code=StatusCode.ERROR,
-                    description=f"{self._self_code}:{details}",
-                )
-            )
+            status = _server_status(self._self_code, details)
+            self._self_active_span.set_status(status)
         return self.__wrapped__.set_details(details)
 
 
diff --git a/instrumentation/opentelemetry-instrumentation-grpc/src/opentelemetry/instrumentation/grpc/_server.py b/instrumentation/opentelemetry-instrumentation-grpc/src/opentelemetry/instrumentation/grpc/_server.py
index 9b66110574..71697ef8bc 100644
--- a/instrumentation/opentelemetry-instrumentation-grpc/src/opentelemetry/instrumentation/grpc/_server.py
+++ b/instrumentation/opentelemetry-instrumentation-grpc/src/opentelemetry/instrumentation/grpc/_server.py
@@ -31,7 +31,8 @@
 from opentelemetry.context import attach, detach
 from opentelemetry.propagate import extract
 from opentelemetry.semconv.trace import SpanAttributes
-from opentelemetry.trace.status import Status, StatusCode
+
+from ._utilities import _server_status
 
 logger = logging.getLogger(__name__)
 
@@ -124,12 +125,8 @@ def abort(self, code, details):
         self._active_span.set_attribute(
             SpanAttributes.RPC_GRPC_STATUS_CODE, code.value[0]
         )
-        self._active_span.set_status(
-            Status(
-                status_code=StatusCode.ERROR,
-                description=f"{code}:{details}",
-            )
-        )
+        status = _server_status(code, details)
+        self._active_span.set_status(status)
         return self._servicer_context.abort(code, details)
 
     def abort_with_status(self, status):
@@ -158,23 +155,15 @@ def set_code(self, code):
             SpanAttributes.RPC_GRPC_STATUS_CODE, code.value[0]
         )
         if code != grpc.StatusCode.OK:
-            self._active_span.set_status(
-                Status(
-                    status_code=StatusCode.ERROR,
-                    description=f"{code}:{details}",
-                )
-            )
+            status = _server_status(code, details)
+            self._active_span.set_status(status)
         return self._servicer_context.set_code(code)
 
     def set_details(self, details):
         self._details = details
         if self._code != grpc.StatusCode.OK:
-            self._active_span.set_status(
-                Status(
-                    status_code=StatusCode.ERROR,
-                    description=f"{self._code}:{details}",
-                )
-            )
+            status = _server_status(self._code, details)
+            self._active_span.set_status(status)
         return self._servicer_context.set_details(details)
 
 
diff --git a/instrumentation/opentelemetry-instrumentation-grpc/src/opentelemetry/instrumentation/grpc/_utilities.py b/instrumentation/opentelemetry-instrumentation-grpc/src/opentelemetry/instrumentation/grpc/_utilities.py
index b6ff7d311a..8a6365b742 100644
--- a/instrumentation/opentelemetry-instrumentation-grpc/src/opentelemetry/instrumentation/grpc/_utilities.py
+++ b/instrumentation/opentelemetry-instrumentation-grpc/src/opentelemetry/instrumentation/grpc/_utilities.py
@@ -14,6 +14,10 @@
 
 """Internal utilities."""
 
+import grpc
+
+from opentelemetry.trace.status import Status, StatusCode
+
 
 class RpcInfo:
     def __init__(
@@ -31,3 +35,21 @@ def __init__(
         self.request = request
         self.response = response
         self.error = error
+
+
+def _server_status(code, details):
+    error_status = Status(
+        status_code=StatusCode.ERROR, description=f"{code}:{details}"
+    )
+    status_codes = {
+        grpc.StatusCode.UNKNOWN: error_status,
+        grpc.StatusCode.DEADLINE_EXCEEDED: error_status,
+        grpc.StatusCode.UNIMPLEMENTED: error_status,
+        grpc.StatusCode.INTERNAL: error_status,
+        grpc.StatusCode.UNAVAILABLE: error_status,
+        grpc.StatusCode.DATA_LOSS: error_status,
+    }
+
+    return status_codes.get(
+        code, Status(status_code=StatusCode.UNSET, description="")
+    )
diff --git a/instrumentation/opentelemetry-instrumentation-grpc/tests/test_aio_server_interceptor.py b/instrumentation/opentelemetry-instrumentation-grpc/tests/test_aio_server_interceptor.py
index 242295c08c..7b31b085de 100644
--- a/instrumentation/opentelemetry-instrumentation-grpc/tests/test_aio_server_interceptor.py
+++ b/instrumentation/opentelemetry-instrumentation-grpc/tests/test_aio_server_interceptor.py
@@ -507,9 +507,7 @@ async def test_abort(self):
         class AbortServicer(GRPCTestServerServicer):
             # pylint:disable=C0103
             async def SimpleMethod(self, request, context):
-                await context.abort(
-                    grpc.StatusCode.FAILED_PRECONDITION, failure_message
-                )
+                await context.abort(grpc.StatusCode.INTERNAL, failure_message)
 
         testcase = self
 
@@ -520,9 +518,7 @@ async def request(channel):
             with testcase.assertRaises(grpc.RpcError) as cm:
                 await channel.unary_unary(rpc_call)(msg)
 
-            self.assertEqual(
-                cm.exception.code(), grpc.StatusCode.FAILED_PRECONDITION
-            )
+            self.assertEqual(cm.exception.code(), grpc.StatusCode.INTERNAL)
             self.assertEqual(cm.exception.details(), failure_message)
 
         await run_with_test_server(request, servicer=AbortServicer())
@@ -543,7 +539,7 @@ async def request(channel):
         self.assertEqual(span.status.status_code, StatusCode.ERROR)
         self.assertEqual(
             span.status.description,
-            f"{grpc.StatusCode.FAILED_PRECONDITION}:{failure_message}",
+            f"{grpc.StatusCode.INTERNAL}:{failure_message}",
         )
 
         # Check attributes
@@ -555,7 +551,7 @@ async def request(channel):
                 SpanAttributes.RPC_METHOD: "SimpleMethod",
                 SpanAttributes.RPC_SERVICE: "GRPCTestServer",
                 SpanAttributes.RPC_SYSTEM: "grpc",
-                SpanAttributes.RPC_GRPC_STATUS_CODE: grpc.StatusCode.FAILED_PRECONDITION.value[
+                SpanAttributes.RPC_GRPC_STATUS_CODE: grpc.StatusCode.INTERNAL.value[
                     0
                 ],
             },
@@ -605,11 +601,8 @@ async def request(channel):
         )
 
         # make sure this span errored, with the right status and detail
-        self.assertEqual(span.status.status_code, StatusCode.ERROR)
-        self.assertEqual(
-            span.status.description,
-            f"{grpc.StatusCode.FAILED_PRECONDITION}:{failure_message}",
-        )
+        self.assertEqual(span.status.status_code, StatusCode.UNSET)
+        self.assertEqual(span.status.description, None)
 
         # Check attributes
         self.assertSpanHasAttributes(
diff --git a/instrumentation/opentelemetry-instrumentation-grpc/tests/test_server_interceptor.py b/instrumentation/opentelemetry-instrumentation-grpc/tests/test_server_interceptor.py
index 57f27c89d6..de79269894 100644
--- a/instrumentation/opentelemetry-instrumentation-grpc/tests/test_server_interceptor.py
+++ b/instrumentation/opentelemetry-instrumentation-grpc/tests/test_server_interceptor.py
@@ -552,28 +552,45 @@ def test_abort(self):
         # our detailed failure message
         failure_message = "This is a test failure"
 
-        # aborting RPC handler
-        def handler(request, context):
+        # aborting RPC handlers
+        def error_status_handler(request, context):
+            context.abort(grpc.StatusCode.INTERNAL, failure_message)
+
+        def unset_status_handler(request, context):
             context.abort(grpc.StatusCode.FAILED_PRECONDITION, failure_message)
 
-        with self.server(
-            max_workers=1,
-            interceptors=[interceptor],
-        ) as (server, channel):
-            server.add_generic_rpc_handlers((UnaryUnaryRpcHandler(handler),))
-            rpc_call = "TestServicer/handler"
+        rpc_call_error = "TestServicer/error_status_handler"
+        rpc_call_unset = "TestServicer/unset_status_handler"
+
+        rpc_calls = {
+            rpc_call_error: error_status_handler,
+            rpc_call_unset: unset_status_handler,
+        }
+
+        for rpc_call, handler in rpc_calls.items():
+            with self.server(
+                max_workers=1,
+                interceptors=[interceptor],
+            ) as (server, channel):
+                server.add_generic_rpc_handlers(
+                    (UnaryUnaryRpcHandler(handler),)
+                )
 
-            server.start()
-            # unfortunately, these are just bare exceptions in grpc...
-            with self.assertRaises(Exception):
-                channel.unary_unary(rpc_call)(b"")
-            server.stop(None)
+                server.start()
+
+                with self.assertRaises(Exception):
+                    channel.unary_unary(rpc_call)(b"")
+
+                # unfortunately, these are just bare exceptions in grpc...
+                server.stop(None)
 
         spans_list = self.memory_exporter.get_finished_spans()
-        self.assertEqual(len(spans_list), 1)
+        self.assertEqual(len(spans_list), 2)
+
+        # check error span
         span = spans_list[0]
 
-        self.assertEqual(span.name, rpc_call)
+        self.assertEqual(span.name, rpc_call_error)
         self.assertIs(span.kind, trace.SpanKind.SERVER)
 
         # Check version and name in span's instrumentation info
@@ -585,15 +602,43 @@ def handler(request, context):
         self.assertEqual(span.status.status_code, StatusCode.ERROR)
         self.assertEqual(
             span.status.description,
-            f"{grpc.StatusCode.FAILED_PRECONDITION}:{failure_message}",
+            f"{grpc.StatusCode.INTERNAL}:{failure_message}",
+        )
+
+        # Check attributes
+        self.assertSpanHasAttributes(
+            span,
+            {
+                **self.net_peer_span_attributes,
+                SpanAttributes.RPC_METHOD: "error_status_handler",
+                SpanAttributes.RPC_SERVICE: "TestServicer",
+                SpanAttributes.RPC_SYSTEM: "grpc",
+                SpanAttributes.RPC_GRPC_STATUS_CODE: grpc.StatusCode.INTERNAL.value[
+                    0
+                ],
+            },
         )
 
+        # check unset status span
+        span = spans_list[1]
+
+        self.assertEqual(span.name, rpc_call_unset)
+        self.assertIs(span.kind, trace.SpanKind.SERVER)
+
+        # Check version and name in span's instrumentation info
+        self.assertEqualSpanInstrumentationInfo(
+            span, opentelemetry.instrumentation.grpc
+        )
+
+        self.assertEqual(span.status.description, None)
+        self.assertEqual(span.status.status_code, StatusCode.UNSET)
+
         # Check attributes
         self.assertSpanHasAttributes(
             span,
             {
                 **self.net_peer_span_attributes,
-                SpanAttributes.RPC_METHOD: "handler",
+                SpanAttributes.RPC_METHOD: "unset_status_handler",
                 SpanAttributes.RPC_SERVICE: "TestServicer",
                 SpanAttributes.RPC_SYSTEM: "grpc",
                 SpanAttributes.RPC_GRPC_STATUS_CODE: grpc.StatusCode.FAILED_PRECONDITION.value[
diff --git a/instrumentation/opentelemetry-instrumentation-httpx/pyproject.toml b/instrumentation/opentelemetry-instrumentation-httpx/pyproject.toml
index f13fa816bc..1a4da4a520 100644
--- a/instrumentation/opentelemetry-instrumentation-httpx/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-httpx/pyproject.toml
@@ -34,11 +34,6 @@ dependencies = [
 instruments = [
   "httpx >= 0.18.0",
 ]
-test = [
-  "opentelemetry-instrumentation-httpx[instruments]",
-  "opentelemetry-sdk ~= 1.12",
-  "opentelemetry-test-utils == 0.45b0.dev",
-]
 
 [project.entry-points.opentelemetry_instrumentor]
 httpx = "opentelemetry.instrumentation.httpx:HTTPXClientInstrumentor"
diff --git a/instrumentation/opentelemetry-instrumentation-httpx/test-requirements-0.txt b/instrumentation/opentelemetry-instrumentation-httpx/test-requirements-0.txt
new file mode 100644
index 0000000000..2d3a8399d8
--- /dev/null
+++ b/instrumentation/opentelemetry-instrumentation-httpx/test-requirements-0.txt
@@ -0,0 +1,28 @@
+anyio==3.7.1
+asgiref==3.7.2
+attrs==23.2.0
+certifi==2024.2.2
+Deprecated==1.2.14
+exceptiongroup==1.2.0
+h11==0.12.0
+httpcore==0.13.7
+httpx==0.18.2
+idna==3.6
+importlib-metadata==6.11.0
+iniconfig==2.0.0
+packaging==23.2
+pluggy==1.4.0
+py==1.11.0
+py-cpuinfo==9.0.0
+pytest==7.1.3
+pytest-benchmark==4.0.0
+respx==0.17.1
+rfc3986==1.5.0
+sniffio==1.3.1
+tomli==2.0.1
+typing_extensions==4.10.0
+wrapt==1.16.0
+zipp==3.17.0
+-e opentelemetry-instrumentation
+-e util/opentelemetry-util-http
+-e instrumentation/opentelemetry-instrumentation-httpx
diff --git a/instrumentation/opentelemetry-instrumentation-httpx/test-requirements-1.txt b/instrumentation/opentelemetry-instrumentation-httpx/test-requirements-1.txt
new file mode 100644
index 0000000000..4a36398fc1
--- /dev/null
+++ b/instrumentation/opentelemetry-instrumentation-httpx/test-requirements-1.txt
@@ -0,0 +1,27 @@
+anyio==4.3.0
+asgiref==3.7.2
+attrs==23.2.0
+certifi==2024.2.2
+Deprecated==1.2.14
+exceptiongroup==1.2.0
+h11==0.14.0
+httpcore==1.0.4
+httpx==0.27.0
+idna==3.6
+importlib-metadata==6.11.0
+iniconfig==2.0.0
+packaging==23.2
+pluggy==1.4.0
+py==1.11.0
+py-cpuinfo==9.0.0
+pytest==7.1.3
+pytest-benchmark==4.0.0
+respx==0.20.2
+sniffio==1.3.1
+tomli==2.0.1
+typing_extensions==4.10.0
+wrapt==1.16.0
+zipp==3.17.0
+-e opentelemetry-instrumentation
+-e util/opentelemetry-util-http
+-e instrumentation/opentelemetry-instrumentation-httpx
diff --git a/instrumentation/opentelemetry-instrumentation-mysqlclient/pyproject.toml b/instrumentation/opentelemetry-instrumentation-mysqlclient/pyproject.toml
index de8c31a1f3..7646a9be2b 100644
--- a/instrumentation/opentelemetry-instrumentation-mysqlclient/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-mysqlclient/pyproject.toml
@@ -33,10 +33,6 @@ dependencies = [
 instruments = [
   "mysqlclient < 3",
 ]
-test = [
-  "opentelemetry-instrumentation-mysqlclient[instruments]",
-  "opentelemetry-test-utils == 0.45b0.dev",
-]
 
 [project.entry-points.opentelemetry_instrumentor]
 mysqlclient = "opentelemetry.instrumentation.mysqlclient:MySQLClientInstrumentor"
diff --git a/instrumentation/opentelemetry-instrumentation-mysqlclient/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-mysqlclient/test-requirements.txt
new file mode 100644
index 0000000000..afa2ccae6c
--- /dev/null
+++ b/instrumentation/opentelemetry-instrumentation-mysqlclient/test-requirements.txt
@@ -0,0 +1,19 @@
+asgiref==3.7.2
+attrs==23.2.0
+Deprecated==1.2.14
+importlib-metadata==6.11.0
+iniconfig==2.0.0
+mysqlclient==2.2.4
+packaging==23.2
+pluggy==1.4.0
+py==1.11.0
+py-cpuinfo==9.0.0
+pytest==7.1.3
+pytest-benchmark==4.0.0
+tomli==2.0.1
+typing_extensions==4.9.0
+wrapt==1.16.0
+zipp==3.17.0
+-e opentelemetry-instrumentation
+-e instrumentation/opentelemetry-instrumentation-dbapi
+-e instrumentation/opentelemetry-instrumentation-mysqlclient
diff --git a/instrumentation/opentelemetry-instrumentation-pymemcache/pyproject.toml b/instrumentation/opentelemetry-instrumentation-pymemcache/pyproject.toml
index e7a642b0aa..e37f566b0b 100644
--- a/instrumentation/opentelemetry-instrumentation-pymemcache/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-pymemcache/pyproject.toml
@@ -34,10 +34,6 @@ dependencies = [
 instruments = [
   "pymemcache >= 1.3.5, < 5",
 ]
-test = [
-  "opentelemetry-instrumentation-pymemcache[instruments]",
-  "opentelemetry-test-utils == 0.45b0.dev",
-]
 
 [project.entry-points.opentelemetry_instrumentor]
 pymemcache = "opentelemetry.instrumentation.pymemcache:PymemcacheInstrumentor"
diff --git a/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-0.txt b/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-0.txt
new file mode 100644
index 0000000000..2e7313ab6e
--- /dev/null
+++ b/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-0.txt
@@ -0,0 +1,19 @@
+asgiref==3.7.2
+attrs==23.2.0
+Deprecated==1.2.14
+importlib-metadata==6.11.0
+iniconfig==2.0.0
+packaging==23.2
+pluggy==1.4.0
+py==1.11.0
+py-cpuinfo==9.0.0
+pymemcache==1.3.5
+pytest==7.1.3
+pytest-benchmark==4.0.0
+six==1.16.0
+tomli==2.0.1
+typing_extensions==4.10.0
+wrapt==1.16.0
+zipp==3.17.0
+-e opentelemetry-instrumentation
+-e instrumentation/opentelemetry-instrumentation-pymemcache
diff --git a/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-1.txt b/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-1.txt
new file mode 100644
index 0000000000..a1a3cc4fb1
--- /dev/null
+++ b/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-1.txt
@@ -0,0 +1,19 @@
+asgiref==3.7.2
+attrs==23.2.0
+Deprecated==1.2.14
+importlib-metadata==6.11.0
+iniconfig==2.0.0
+packaging==23.2
+pluggy==1.4.0
+py==1.11.0
+py-cpuinfo==9.0.0
+pymemcache==2.2.2
+pytest==7.1.3
+pytest-benchmark==4.0.0
+six==1.16.0
+tomli==2.0.1
+typing_extensions==4.10.0
+wrapt==1.16.0
+zipp==3.17.0
+-e opentelemetry-instrumentation
+-e instrumentation/opentelemetry-instrumentation-pymemcache
diff --git a/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-2.txt b/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-2.txt
new file mode 100644
index 0000000000..cb28ea22d7
--- /dev/null
+++ b/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-2.txt
@@ -0,0 +1,19 @@
+asgiref==3.7.2
+attrs==23.2.0
+Deprecated==1.2.14
+importlib-metadata==6.11.0
+iniconfig==2.0.0
+packaging==23.2
+pluggy==1.4.0
+py==1.11.0
+py-cpuinfo==9.0.0
+pymemcache==3.4.1
+pytest==7.1.3
+pytest-benchmark==4.0.0
+six==1.16.0
+tomli==2.0.1
+typing_extensions==4.10.0
+wrapt==1.16.0
+zipp==3.17.0
+-e opentelemetry-instrumentation
+-e instrumentation/opentelemetry-instrumentation-pymemcache
diff --git a/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-3.txt b/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-3.txt
new file mode 100644
index 0000000000..40152664ac
--- /dev/null
+++ b/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-3.txt
@@ -0,0 +1,19 @@
+asgiref==3.7.2
+attrs==23.2.0
+Deprecated==1.2.14
+importlib-metadata==6.11.0
+iniconfig==2.0.0
+packaging==23.2
+pluggy==1.4.0
+py==1.11.0
+py-cpuinfo==9.0.0
+pymemcache==3.4.2
+pytest==7.1.3
+pytest-benchmark==4.0.0
+six==1.16.0
+tomli==2.0.1
+typing_extensions==4.10.0
+wrapt==1.16.0
+zipp==3.17.0
+-e opentelemetry-instrumentation
+-e instrumentation/opentelemetry-instrumentation-pymemcache
diff --git a/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-4.txt b/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-4.txt
new file mode 100644
index 0000000000..9031276ce4
--- /dev/null
+++ b/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-4.txt
@@ -0,0 +1,18 @@
+asgiref==3.7.2
+attrs==23.2.0
+Deprecated==1.2.14
+importlib-metadata==6.11.0
+iniconfig==2.0.0
+packaging==23.2
+pluggy==1.4.0
+py==1.11.0
+py-cpuinfo==9.0.0
+pymemcache==4.0.0
+pytest==7.1.3
+pytest-benchmark==4.0.0
+tomli==2.0.1
+typing_extensions==4.10.0
+wrapt==1.16.0
+zipp==3.17.0
+-e opentelemetry-instrumentation
+-e instrumentation/opentelemetry-instrumentation-pymemcache
diff --git a/instrumentation/opentelemetry-instrumentation-pyramid/pyproject.toml b/instrumentation/opentelemetry-instrumentation-pyramid/pyproject.toml
index 1face37ccc..4f6577d4a8 100644
--- a/instrumentation/opentelemetry-instrumentation-pyramid/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-pyramid/pyproject.toml
@@ -36,11 +36,6 @@ dependencies = [
 instruments = [
   "pyramid >= 1.7",
 ]
-test = [
-  "opentelemetry-instrumentation-pyramid[instruments]",
-  "opentelemetry-test-utils == 0.45b0.dev",
-  "werkzeug == 0.16.1",
-]
 
 [project.entry-points.opentelemetry_instrumentor]
 pyramid = "opentelemetry.instrumentation.pyramid:PyramidInstrumentor"
diff --git a/instrumentation/opentelemetry-instrumentation-pyramid/src/opentelemetry/instrumentation/pyramid/callbacks.py b/instrumentation/opentelemetry-instrumentation-pyramid/src/opentelemetry/instrumentation/pyramid/callbacks.py
index e3675fcfab..4f17da3da5 100644
--- a/instrumentation/opentelemetry-instrumentation-pyramid/src/opentelemetry/instrumentation/pyramid/callbacks.py
+++ b/instrumentation/opentelemetry-instrumentation-pyramid/src/opentelemetry/instrumentation/pyramid/callbacks.py
@@ -140,7 +140,7 @@ def trace_tween_factory(handler, registry):
     duration_histogram = meter.create_histogram(
         name=MetricInstruments.HTTP_SERVER_DURATION,
         unit="ms",
-        description="measures the duration of the inbound HTTP request",
+        description="Duration of HTTP client requests.",
     )
     active_requests_counter = meter.create_up_down_counter(
         name=MetricInstruments.HTTP_SERVER_ACTIVE_REQUESTS,
diff --git a/instrumentation/opentelemetry-instrumentation-pyramid/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-pyramid/test-requirements.txt
new file mode 100644
index 0000000000..1362e7166e
--- /dev/null
+++ b/instrumentation/opentelemetry-instrumentation-pyramid/test-requirements.txt
@@ -0,0 +1,30 @@
+asgiref==3.7.2
+attrs==23.2.0
+Deprecated==1.2.14
+hupper==1.12.1
+importlib-metadata==6.11.0
+iniconfig==2.0.0
+packaging==23.2
+PasteDeploy==3.1.0
+plaster==1.1.2
+plaster-pastedeploy==1.0.1
+pluggy==1.4.0
+py==1.11.0
+py-cpuinfo==9.0.0
+pyramid==2.0.2
+pytest==7.1.3
+pytest-benchmark==4.0.0
+tomli==2.0.1
+translationstring==1.4
+typing_extensions==4.9.0
+venusian==3.1.0
+WebOb==1.8.7
+Werkzeug==0.16.1
+wrapt==1.16.0
+zipp==3.17.0
+zope.deprecation==5.0
+zope.interface==6.2
+-e opentelemetry-instrumentation
+-e instrumentation/opentelemetry-instrumentation-wsgi
+-e util/opentelemetry-util-http
+-e instrumentation/opentelemetry-instrumentation-pyramid
diff --git a/instrumentation/opentelemetry-instrumentation-requests/pyproject.toml b/instrumentation/opentelemetry-instrumentation-requests/pyproject.toml
index a4f8255e00..ce83ca93ac 100644
--- a/instrumentation/opentelemetry-instrumentation-requests/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-requests/pyproject.toml
@@ -34,11 +34,6 @@ dependencies = [
 instruments = [
   "requests ~= 2.0",
 ]
-test = [
-  "opentelemetry-instrumentation-requests[instruments]",
-  "httpretty ~= 1.0",
-  "opentelemetry-test-utils == 0.45b0.dev",
-]
 
 [project.entry-points.opentelemetry_instrumentor]
 requests = "opentelemetry.instrumentation.requests:RequestsInstrumentor"
diff --git a/instrumentation/opentelemetry-instrumentation-requests/src/opentelemetry/instrumentation/requests/__init__.py b/instrumentation/opentelemetry-instrumentation-requests/src/opentelemetry/instrumentation/requests/__init__.py
index 4c198596a2..d0150d57b7 100644
--- a/instrumentation/opentelemetry-instrumentation-requests/src/opentelemetry/instrumentation/requests/__init__.py
+++ b/instrumentation/opentelemetry-instrumentation-requests/src/opentelemetry/instrumentation/requests/__init__.py
@@ -105,7 +105,7 @@
 _excluded_urls_from_env = get_excluded_urls("REQUESTS")
 
 _RequestHookT = Optional[Callable[[Span, PreparedRequest], None]]
-_ResponseHookT = Optional[Callable[[Span, PreparedRequest], None]]
+_ResponseHookT = Optional[Callable[[Span, PreparedRequest, Response], None]]
 
 
 # pylint: disable=unused-argument
diff --git a/instrumentation/opentelemetry-instrumentation-requests/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-requests/test-requirements.txt
new file mode 100644
index 0000000000..be34594506
--- /dev/null
+++ b/instrumentation/opentelemetry-instrumentation-requests/test-requirements.txt
@@ -0,0 +1,24 @@
+asgiref==3.7.2
+attrs==23.2.0
+certifi==2024.2.2
+charset-normalizer==3.3.2
+Deprecated==1.2.14
+httpretty==1.1.4
+idna==3.6
+importlib-metadata==6.11.0
+iniconfig==2.0.0
+packaging==23.2
+pluggy==1.4.0
+py==1.11.0
+py-cpuinfo==9.0.0
+pytest==7.1.3
+pytest-benchmark==4.0.0
+requests==2.31.0
+tomli==2.0.1
+typing_extensions==4.9.0
+urllib3==2.2.1
+wrapt==1.16.0
+zipp==3.17.0
+-e opentelemetry-instrumentation
+-e util/opentelemetry-util-http
+-e instrumentation/opentelemetry-instrumentation-requests
diff --git a/instrumentation/opentelemetry-instrumentation-starlette/pyproject.toml b/instrumentation/opentelemetry-instrumentation-starlette/pyproject.toml
index 8b2f2a7014..a73d5b0455 100644
--- a/instrumentation/opentelemetry-instrumentation-starlette/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-starlette/pyproject.toml
@@ -35,12 +35,6 @@ dependencies = [
 instruments = [
   "starlette ~= 0.13.0",
 ]
-test = [
-  "opentelemetry-instrumentation-starlette[instruments]",
-  "opentelemetry-test-utils == 0.45b0.dev",
-  "requests ~= 2.23", # needed for testclient
-  "httpx ~= 0.22", # needed for testclient
-]
 
 [project.entry-points.opentelemetry_instrumentor]
 starlette = "opentelemetry.instrumentation.starlette:StarletteInstrumentor"
diff --git a/instrumentation/opentelemetry-instrumentation-starlette/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-starlette/test-requirements.txt
new file mode 100644
index 0000000000..1cd21039a7
--- /dev/null
+++ b/instrumentation/opentelemetry-instrumentation-starlette/test-requirements.txt
@@ -0,0 +1,31 @@
+anyio==4.3.0
+asgiref==3.7.2
+attrs==23.2.0
+certifi==2024.2.2
+charset-normalizer==3.3.2
+Deprecated==1.2.14
+exceptiongroup==1.2.0
+h11==0.14.0
+httpcore==1.0.4
+httpx==0.27.0
+idna==3.6
+importlib-metadata==6.11.0
+iniconfig==2.0.0
+packaging==23.2
+pluggy==1.4.0
+py==1.11.0
+py-cpuinfo==9.0.0
+pytest==7.1.3
+pytest-benchmark==4.0.0
+requests==2.31.0
+sniffio==1.3.0
+starlette==0.13.8
+tomli==2.0.1
+typing_extensions==4.9.0
+urllib3==2.2.1
+wrapt==1.16.0
+zipp==3.17.0
+-e opentelemetry-instrumentation
+-e instrumentation/opentelemetry-instrumentation-asgi
+-e util/opentelemetry-util-http
+-e instrumentation/opentelemetry-instrumentation-starlette
diff --git a/instrumentation/opentelemetry-instrumentation-tornado/pyproject.toml b/instrumentation/opentelemetry-instrumentation-tornado/pyproject.toml
index 54706b42f2..e56a566410 100644
--- a/instrumentation/opentelemetry-instrumentation-tornado/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-tornado/pyproject.toml
@@ -33,11 +33,6 @@ dependencies = [
 instruments = [
   "tornado >= 5.1.1",
 ]
-test = [
-  "opentelemetry-instrumentation-tornado[instruments]",
-  "opentelemetry-test-utils == 0.45b0.dev",
-  "http-server-mock"
-]
 
 [project.entry-points.opentelemetry_instrumentor]
 tornado = "opentelemetry.instrumentation.tornado:TornadoInstrumentor"
diff --git a/instrumentation/opentelemetry-instrumentation-tornado/src/opentelemetry/instrumentation/tornado/__init__.py b/instrumentation/opentelemetry-instrumentation-tornado/src/opentelemetry/instrumentation/tornado/__init__.py
index dfa4b217df..5a39538837 100644
--- a/instrumentation/opentelemetry-instrumentation-tornado/src/opentelemetry/instrumentation/tornado/__init__.py
+++ b/instrumentation/opentelemetry-instrumentation-tornado/src/opentelemetry/instrumentation/tornado/__init__.py
@@ -296,7 +296,7 @@ def _create_server_histograms(meter) -> Dict[str, Histogram]:
         MetricInstruments.HTTP_SERVER_DURATION: meter.create_histogram(
             name=MetricInstruments.HTTP_SERVER_DURATION,
             unit="ms",
-            description="measures the duration outbound HTTP requests",
+            description="Duration of HTTP client requests.",
         ),
         MetricInstruments.HTTP_SERVER_REQUEST_SIZE: meter.create_histogram(
             name=MetricInstruments.HTTP_SERVER_REQUEST_SIZE,
diff --git a/instrumentation/opentelemetry-instrumentation-tornado/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-tornado/test-requirements.txt
new file mode 100644
index 0000000000..9f637278fd
--- /dev/null
+++ b/instrumentation/opentelemetry-instrumentation-tornado/test-requirements.txt
@@ -0,0 +1,32 @@
+asgiref==3.7.2
+attrs==23.2.0
+blinker==1.7.0
+certifi==2024.2.2
+charset-normalizer==3.3.2
+click==8.1.7
+Deprecated==1.2.14
+Flask==3.0.2
+http_server_mock==1.7
+idna==3.6
+importlib-metadata==6.11.0
+iniconfig==2.0.0
+itsdangerous==2.1.2
+Jinja2==3.1.3
+MarkupSafe==2.1.5
+packaging==23.2
+pluggy==1.4.0
+py==1.11.0
+py-cpuinfo==9.0.0
+pytest==7.1.3
+pytest-benchmark==4.0.0
+requests==2.31.0
+tomli==2.0.1
+tornado==6.4
+typing_extensions==4.9.0
+urllib3==2.2.1
+Werkzeug==3.0.1
+wrapt==1.16.0
+zipp==3.17.0
+-e opentelemetry-instrumentation
+-e util/opentelemetry-util-http
+-e instrumentation/opentelemetry-instrumentation-tornado
diff --git a/instrumentation/opentelemetry-instrumentation-tornado/tests/test_instrumentation.py b/instrumentation/opentelemetry-instrumentation-tornado/tests/test_instrumentation.py
index 0baaa348ab..01cdddceed 100644
--- a/instrumentation/opentelemetry-instrumentation-tornado/tests/test_instrumentation.py
+++ b/instrumentation/opentelemetry-instrumentation-tornado/tests/test_instrumentation.py
@@ -528,7 +528,7 @@ def index():
 
 
 class TestTornadoInstrumentationWithXHeaders(TornadoTest):
-    def get_httpserver_options(self):
+    def get_httpserver_options(self):  # pylint: disable=no-self-use
         return {"xheaders": True}
 
     def test_xheaders(self):
diff --git a/instrumentation/opentelemetry-instrumentation-tortoiseorm/README.rst b/instrumentation/opentelemetry-instrumentation-tortoiseorm/README.rst
index e845fbf84d..22d6c01731 100644
--- a/instrumentation/opentelemetry-instrumentation-tortoiseorm/README.rst
+++ b/instrumentation/opentelemetry-instrumentation-tortoiseorm/README.rst
@@ -19,5 +19,5 @@ References
 ----------
 
 * `OpenTelemetry Project <https://opentelemetry.io/>`_
-* `Tortoise ORM <https://tortoise-orm.readthedocs.io/en/latest/>`_
+* `Tortoise ORM <https://tortoise.github.io/>`_
 * `OpenTelemetry Python Examples <https://github.com/open-telemetry/opentelemetry-python/tree/main/docs/examples>`_
diff --git a/instrumentation/opentelemetry-instrumentation-urllib/pyproject.toml b/instrumentation/opentelemetry-instrumentation-urllib/pyproject.toml
index 3fe6d272cb..08a0f90aca 100644
--- a/instrumentation/opentelemetry-instrumentation-urllib/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-urllib/pyproject.toml
@@ -32,10 +32,6 @@ dependencies = [
 
 [project.optional-dependencies]
 instruments = []
-test = [
-  "httpretty ~= 1.0",
-  "opentelemetry-test-utils == 0.45b0.dev",
-]
 
 [project.entry-points.opentelemetry_instrumentor]
 urllib = "opentelemetry.instrumentation.urllib:URLLibInstrumentor"
diff --git a/instrumentation/opentelemetry-instrumentation-urllib/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-urllib/test-requirements.txt
new file mode 100644
index 0000000000..cdb10df7e9
--- /dev/null
+++ b/instrumentation/opentelemetry-instrumentation-urllib/test-requirements.txt
@@ -0,0 +1,19 @@
+asgiref==3.7.2
+attrs==23.2.0
+Deprecated==1.2.14
+httpretty==1.1.4
+importlib-metadata==6.11.0
+iniconfig==2.0.0
+packaging==23.2
+pluggy==1.4.0
+py==1.11.0
+py-cpuinfo==9.0.0
+pytest==7.1.3
+pytest-benchmark==4.0.0
+tomli==2.0.1
+typing_extensions==4.9.0
+wrapt==1.16.0
+zipp==3.17.0
+-e opentelemetry-instrumentation
+-e util/opentelemetry-util-http
+-e instrumentation/opentelemetry-instrumentation-urllib
diff --git a/instrumentation/opentelemetry-instrumentation-urllib3/pyproject.toml b/instrumentation/opentelemetry-instrumentation-urllib3/pyproject.toml
index fbd27f7bd8..628cb46554 100644
--- a/instrumentation/opentelemetry-instrumentation-urllib3/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-urllib3/pyproject.toml
@@ -35,11 +35,6 @@ dependencies = [
 instruments = [
   "urllib3 >= 1.0.0, < 3.0.0",
 ]
-test = [
-  "opentelemetry-instrumentation-urllib3[instruments]",
-  "httpretty ~= 1.0",
-  "opentelemetry-test-utils == 0.45b0.dev",
-]
 
 [project.entry-points.opentelemetry_instrumentor]
 urllib3 = "opentelemetry.instrumentation.urllib3:URLLib3Instrumentor"
diff --git a/instrumentation/opentelemetry-instrumentation-urllib3/test-requirements-0.txt b/instrumentation/opentelemetry-instrumentation-urllib3/test-requirements-0.txt
new file mode 100644
index 0000000000..730ef16977
--- /dev/null
+++ b/instrumentation/opentelemetry-instrumentation-urllib3/test-requirements-0.txt
@@ -0,0 +1,20 @@
+asgiref==3.7.2
+attrs==23.2.0
+Deprecated==1.2.14
+httpretty==1.1.4
+importlib-metadata==6.11.0
+iniconfig==2.0.0
+packaging==23.2
+pluggy==1.4.0
+py==1.11.0
+py-cpuinfo==9.0.0
+pytest==7.1.3
+pytest-benchmark==4.0.0
+tomli==2.0.1
+typing_extensions==4.10.0
+urllib3==1.26.18
+wrapt==1.16.0
+zipp==3.17.0
+-e opentelemetry-instrumentation
+-e util/opentelemetry-util-http
+-e instrumentation/opentelemetry-instrumentation-urllib3
diff --git a/instrumentation/opentelemetry-instrumentation-urllib3/test-requirements-1.txt b/instrumentation/opentelemetry-instrumentation-urllib3/test-requirements-1.txt
new file mode 100644
index 0000000000..1f10502f57
--- /dev/null
+++ b/instrumentation/opentelemetry-instrumentation-urllib3/test-requirements-1.txt
@@ -0,0 +1,20 @@
+asgiref==3.7.2
+attrs==23.2.0
+Deprecated==1.2.14
+httpretty==1.1.4
+importlib-metadata==6.11.0
+iniconfig==2.0.0
+packaging==23.2
+pluggy==1.4.0
+py==1.11.0
+py-cpuinfo==9.0.0
+pytest==7.1.3
+pytest-benchmark==4.0.0
+tomli==2.0.1
+typing_extensions==4.10.0
+urllib3==2.2.1
+wrapt==1.16.0
+zipp==3.17.0
+-e opentelemetry-instrumentation
+-e util/opentelemetry-util-http
+-e instrumentation/opentelemetry-instrumentation-urllib3
diff --git a/instrumentation/opentelemetry-instrumentation-wsgi/pyproject.toml b/instrumentation/opentelemetry-instrumentation-wsgi/pyproject.toml
index bb1b6ef286..69b0e7ff41 100644
--- a/instrumentation/opentelemetry-instrumentation-wsgi/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-wsgi/pyproject.toml
@@ -32,9 +32,6 @@ dependencies = [
 
 [project.optional-dependencies]
 instruments = []
-test = [
-  "opentelemetry-test-utils == 0.45b0.dev",
-]
 
 [project.urls]
 Homepage = "https://github.com/open-telemetry/opentelemetry-python-contrib/tree/main/instrumentation/opentelemetry-instrumentation-wsgi"
diff --git a/instrumentation/opentelemetry-instrumentation-wsgi/src/opentelemetry/instrumentation/wsgi/__init__.py b/instrumentation/opentelemetry-instrumentation-wsgi/src/opentelemetry/instrumentation/wsgi/__init__.py
index 87c73cc737..afa1bf2a55 100644
--- a/instrumentation/opentelemetry-instrumentation-wsgi/src/opentelemetry/instrumentation/wsgi/__init__.py
+++ b/instrumentation/opentelemetry-instrumentation-wsgi/src/opentelemetry/instrumentation/wsgi/__init__.py
@@ -507,7 +507,7 @@ def __init__(
         self.duration_histogram = self.meter.create_histogram(
             name=MetricInstruments.HTTP_SERVER_DURATION,
             unit="ms",
-            description="measures the duration of the inbound HTTP request",
+            description="Duration of HTTP client requests.",
         )
         self.active_requests_counter = self.meter.create_up_down_counter(
             name=MetricInstruments.HTTP_SERVER_ACTIVE_REQUESTS,
diff --git a/instrumentation/opentelemetry-instrumentation-wsgi/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-wsgi/test-requirements.txt
new file mode 100644
index 0000000000..a4910352ed
--- /dev/null
+++ b/instrumentation/opentelemetry-instrumentation-wsgi/test-requirements.txt
@@ -0,0 +1,18 @@
+asgiref==3.7.2
+attrs==23.2.0
+Deprecated==1.2.14
+importlib-metadata==6.11.0
+iniconfig==2.0.0
+packaging==23.2
+pluggy==1.4.0
+py==1.11.0
+py-cpuinfo==9.0.0
+pytest==7.1.3
+pytest-benchmark==4.0.0
+tomli==2.0.1
+typing_extensions==4.9.0
+wrapt==1.16.0
+zipp==3.17.0
+-e opentelemetry-instrumentation
+-e util/opentelemetry-util-http
+-e instrumentation/opentelemetry-instrumentation-wsgi
diff --git a/opentelemetry-contrib-instrumentations/pyproject.toml b/opentelemetry-contrib-instrumentations/pyproject.toml
index 2ed7ccec87..1cd2c37625 100644
--- a/opentelemetry-contrib-instrumentations/pyproject.toml
+++ b/opentelemetry-contrib-instrumentations/pyproject.toml
@@ -77,9 +77,6 @@ dependencies = [
     "opentelemetry-instrumentation-wsgi==0.45b0.dev",
 ]
 
-[project.optional-dependencies]
-test = []
-
 [project.urls]
 Homepage = "https://github.com/open-telemetry/opentelemetry-python-contrib/tree/main/opentelemetry-contrib-instrumentations"
 
diff --git a/scripts/prepare_release.sh b/scripts/prepare_release.sh
index a0bb15f216..66ed3c593e 100755
--- a/scripts/prepare_release.sh
+++ b/scripts/prepare_release.sh
@@ -1,5 +1,6 @@
 #!/bin/bash
-#
+set -e
+
 # This script:
 #   1. parses the version number from the branch name
 #   2. updates version.py files to match that version
diff --git a/tox.ini b/tox.ini
index 820ac93816..8ac6a4606f 100644
--- a/tox.ini
+++ b/tox.ini
@@ -52,10 +52,18 @@ envlist =
     ; Only officially supported Python versions are tested for each Django
     ; major release. Updated list can be found at:
     ; https://docs.djangoproject.com/en/dev/faq/install/#what-python-version-can-i-use-with-django
+    ; The numbers at the end of the environment names
+    ; below mean these dependencies are being used:
+    ; 0: django~=2.0
+    ; 1: django~=3.0
+    ; 2: django>=4.0b1,<5.0 backports.zoneinfo==0.2.1
+    ; 3: django>=4.0b1,<5.0
+    py3{8,9}-test-instrumentation-django-0
+    py3{8,9}-test-instrumentation-django-1
     py3{8,9}-test-instrumentation-django-2
-    py3{8,9,10,11}-test-instrumentation-django-3
-    py3{8,9,10,11}-test-instrumentation-django-4
-    pypy3-test-instrumentation-django-{2,3}
+    py3{10,11}-test-instrumentation-django-1
+    py3{10,11}-test-instrumentation-django-3
+    pypy3-test-instrumentation-django-{0,1}
 
     ; opentelemetry-instrumentation-dbapi
     py3{8,9,10,11}-test-instrumentation-dbapi
@@ -67,33 +75,53 @@ envlist =
     ; pypy3-test-instrumentation-boto
 
     ; opentelemetry-instrumentation-elasticsearch
-    py3{8,9,10,11}-test-instrumentation-elasticsearch-{2,6}
-    pypy3-test-instrumentation-elasticsearch-{2,6}
-    py3{8,9}-test-instrumentation-elasticsearch-5
-    pypy3-test-instrumentation-elasticsearch-5
+    ; FIXME: Elasticsearch >=7 causes CI workflow tests to hang, see open-telemetry/opentelemetry-python-contrib#620
+    ; The numbers at the end of the environment names
+    ; below mean these dependencies are being used:
+    ; 0: elasticsearch-dsl>=2.0,<3.0 elasticsearch>=2.0,<3.0
+    ; 1: elasticsearch-dsl>=5.0,<6.0 elasticsearch>=5.0,<6.0
+    ; 2: elasticsearch-dsl>=6.0,<7.0 elasticsearch>=6.0,<7.0
+    py3{8,9,10,11}-test-instrumentation-elasticsearch-{0,2}
+    pypy3-test-instrumentation-elasticsearch-{0,2}
+    py3{8,9}-test-instrumentation-elasticsearch-1
+    pypy3-test-instrumentation-elasticsearch-1
 
     ; opentelemetry-instrumentation-falcon
     ; py310 does not work with falcon 1
-    py3{8,9}-test-instrumentation-falcon-1
-    py3{8,9,10,11}-test-instrumentation-falcon-{2,3}
-    pypy3-test-instrumentation-falcon-{1,2,3}
+    ; The numbers at the end of the environment names
+    ; below mean these dependencies are being used:
+    ; 0: falcon ==1.4.1
+    ; 1: falcon >=2.0.0,<3.0.0
+    ; 2: falcon >=3.0.0,<4.0.0
+    py3{8,9}-test-instrumentation-falcon-0
+    py3{8,9,10,11}-test-instrumentation-falcon-{1,2}
+    pypy3-test-instrumentation-falcon-{0,1,2}
 
     ; opentelemetry-instrumentation-fastapi
     py3{8,9,10,11}-test-instrumentation-fastapi
     pypy3-test-instrumentation-fastapi
 
     ; opentelemetry-instrumentation-flask
-    py3{8,9,10,11}-test-instrumentation-flask-{213,220}
-    py3{8,9,10,11}-test-instrumentation-flask-{300}
-    pypy3-test-instrumentation-flask-{213,220}
+    ; The numbers at the end of the environment names
+    ; below mean these dependencies are being used:
+    ; 0: Flask ==2.1.3 Werkzeug <3.0.0
+    ; 1: Flask ==2.2.0 Werkzeug <3.0.0
+    ; 2: Flask >=3.0.0 Werkzeug >=3.0.0
+    py3{8,9,10,11}-test-instrumentation-flask-{0,1}
+    py3{8,9,10,11}-test-instrumentation-flask-{2}
+    pypy3-test-instrumentation-flask-{0,1}
 
     ; opentelemetry-instrumentation-urllib
     py3{8,9,10,11}-test-instrumentation-urllib
     pypy3-test-instrumentation-urllib
 
     ; opentelemetry-instrumentation-urllib3
-    py3{8,9,10,11}-test-instrumentation-urllib3v-{1,2}
-    pypy3-test-instrumentation-urllib3v-{1,2}
+    ; The numbers at the end of the environment names
+    ; below mean these dependencies are being used:
+    ; 0: urllib3 >=1.0.0,<2.0.0
+    ; 1: urllib3 >=2.0.0,<3.0.0
+    py3{8,9,10,11}-test-instrumentation-urllib3-{0,1}
+    pypy3-test-instrumentation-urllib3-{0,1}
 
     ; opentelemetry-instrumentation-requests
     py3{8,9,10,11}-test-instrumentation-requests
@@ -136,8 +164,15 @@ envlist =
     pypy3-test-instrumentation-psycopg
 
     ; opentelemetry-instrumentation-pymemcache
-    py3{8,9,10,11}-test-instrumentation-pymemcache-{135,200,300,342,400}
-    pypy3-test-instrumentation-pymemcache-{135,200,300,342,400}
+    ; The numbers at the end of the environment names
+    ; below mean these dependencies are being used:
+    ; 0: pymemcache ==1.3.5
+    ; 1: pymemcache >2.0.0,<3.0.0
+    ; 2: pymemcache >3.0.0,<3.4.2
+    ; 3: pymemcache ==3.4.2
+    ; 4: pymemcache ==4.0.0
+    py3{8,9,10,11}-test-instrumentation-pymemcache-{0,1,2,3,4}
+    pypy3-test-instrumentation-pymemcache-{0,1,2,3,4}
 
     ; opentelemetry-instrumentation-pymongo
     py3{8,9,10,11}-test-instrumentation-pymongo
@@ -203,8 +238,8 @@ envlist =
     pypy3-test-instrumentation-tortoiseorm
 
     ; opentelemetry-instrumentation-httpx
-    py3{8,9,10,11}-test-instrumentation-httpx-{18,21}
-    pypy3-test-instrumentation-httpx-{18,21}
+    py3{8,9,10,11}-test-instrumentation-httpx-{0,1}
+    pypy3-test-instrumentation-httpx-{0,1}
 
     ; opentelemetry-util-http
     py3{8,9,10,11}-test-util-http
@@ -223,8 +258,13 @@ envlist =
     pypy3-test-instrumentation-sio-pika-{0,1}
 
     ; opentelemetry-instrumentation-aio-pika
-    py3{8,9,10,11}-test-instrumentation-aio-pika-{8,9}
-    pypy3-test-instrumentation-aio-pika-{8,9}
+    ; The numbers at the end of the environment names
+    ; below mean these dependencies are being used:
+    ; 0: aio_pika~=7.2.0
+    ; 1: aio_pika>=8.0.0,<9.0.0
+    ; 2: aio_pika>=9.0.0,<10.0.0
+    py3{8,9,10,11}-test-instrumentation-aio-pika-{0,1,2}
+    pypy3-test-instrumentation-aio-pika-{0,1,2}
 
     ; opentelemetry-instrumentation-kafka-python
     py3{8,9,10,11}-test-instrumentation-kafka-python
@@ -255,49 +295,12 @@ deps =
   test: pytest-benchmark
   coverage: pytest
   coverage: pytest-cov
-  django-2: django~=2.0
-  django-3: django~=3.0
-  django-4: django>=4.0b1,<5.0
-  elasticsearch-2: elasticsearch-dsl>=2.0,<3.0
-  elasticsearch-2: elasticsearch>=2.0,<3.0
-  elasticsearch-5: elasticsearch-dsl>=5.0,<6.0
-  elasticsearch-5: elasticsearch>=5.0,<6.0
-  elasticsearch-6: elasticsearch-dsl>=6.0,<7.0
-  elasticsearch-6: elasticsearch>=6.0,<7.0
-  ; FIXME: Elasticsearch >=7 causes CI workflow tests to hang, see open-telemetry/opentelemetry-python-contrib#620
-  ; elasticsearch-7: elasticsearch-dsl>=7.0,<8.0
-  ; elasticsearch-7: elasticsearch>=7.0,<8.0
-  ; elasticsearch-8: elasticsearch-dsl>=8.0,<9.0
-  ; elasticsearch-8: elasticsearch>=8.0,<9.0
-  falcon-1: falcon ==1.4.1
-  falcon-2: falcon >=2.0.0,<3.0.0
-  falcon-3: falcon >=3.0.0,<4.0.0
-  flask-213: Flask ==2.1.3
-  flask-213: Werkzeug <3.0.0
-  flask-220: Flask ==2.2.0
-  flask-220: Werkzeug <3.0.0
-  flask-300: Flask >=3.0.0
-  flask-300: Werkzeug >=3.0.0
   grpc: pytest-asyncio
   sqlalchemy-11: sqlalchemy>=1.1,<1.2
   sqlalchemy-14: aiosqlite
   sqlalchemy-14: sqlalchemy~=1.4
   sio-pika-0: pika>=0.12.0,<1.0.0
   sio-pika-1: pika>=1.0.0
-  aio-pika-7: aio_pika~=7.2.0
-  aio-pika-8: aio_pika>=8.0.0,<9.0.0
-  aio-pika-9: aio_pika>=9.0.0,<10.0.0
-  pymemcache-135: pymemcache ==1.3.5
-  pymemcache-200: pymemcache >2.0.0,<3.0.0
-  pymemcache-300: pymemcache >3.0.0,<3.4.2
-  pymemcache-342: pymemcache ==3.4.2
-  pymemcache-400: pymemcache ==4.0.0
-  httpx-18: httpx>=0.18.0,<0.19.0
-  httpx-18: respx~=0.17.0
-  httpx-21: httpx>=0.19.0
-  httpx-21: respx~=0.20.1
-  urllib3v-1: urllib3 >=1.0.0,<2.0.0
-  urllib3v-2: urllib3 >=2.0.0,<3.0.0
 
   ; FIXME: add coverage testing
   ; FIXME: add mypy testing
@@ -308,64 +311,6 @@ setenv =
   CORE_REPO_SHA={env:CORE_REPO_SHA:main}
   CORE_REPO=git+https://github.com/open-telemetry/opentelemetry-python.git@{env:CORE_REPO_SHA}
 
-changedir =
-  test-distro: opentelemetry-distro/tests
-  test-opentelemetry-instrumentation: opentelemetry-instrumentation/tests
-  test-instrumentation-aiohttp-client: instrumentation/opentelemetry-instrumentation-aiohttp-client/tests
-  test-instrumentation-aiohttp-server: instrumentation/opentelemetry-instrumentation-aiohttp-server/tests
-  test-instrumentation-aiopg: instrumentation/opentelemetry-instrumentation-aiopg/tests
-  test-instrumentation-asgi: instrumentation/opentelemetry-instrumentation-asgi/tests
-  test-instrumentation-asyncpg: instrumentation/opentelemetry-instrumentation-asyncpg/tests
-  test-instrumentation-aws-lambda: instrumentation/opentelemetry-instrumentation-aws-lambda/tests
-  test-instrumentation-boto: instrumentation/opentelemetry-instrumentation-boto/tests
-  test-instrumentation-botocore: instrumentation/opentelemetry-instrumentation-botocore/tests
-  test-instrumentation-boto3sqs: instrumentation/opentelemetry-instrumentation-boto3sqs/tests
-  test-instrumentation-cassandra: instrumentation/opentelemetry-instrumentation-cassandra/tests
-  test-instrumentation-celery: instrumentation/opentelemetry-instrumentation-celery/tests
-  test-instrumentation-dbapi: instrumentation/opentelemetry-instrumentation-dbapi/tests
-  test-instrumentation-django-{1,2,3,4}: instrumentation/opentelemetry-instrumentation-django/tests
-  test-instrumentation-elasticsearch-{2,5,6}: instrumentation/opentelemetry-instrumentation-elasticsearch/tests
-  test-instrumentation-falcon-{1,2,3}: instrumentation/opentelemetry-instrumentation-falcon/tests
-  test-instrumentation-fastapi: instrumentation/opentelemetry-instrumentation-fastapi/tests
-  test-instrumentation-flask-{213,220,300}: instrumentation/opentelemetry-instrumentation-flask/tests
-  test-instrumentation-urllib: instrumentation/opentelemetry-instrumentation-urllib/tests
-  test-instrumentation-urllib3v-{1,2}: instrumentation/opentelemetry-instrumentation-urllib3/tests
-  test-instrumentation-grpc: instrumentation/opentelemetry-instrumentation-grpc/tests
-  test-instrumentation-jinja2: instrumentation/opentelemetry-instrumentation-jinja2/tests
-  test-instrumentation-kafka-python: instrumentation/opentelemetry-instrumentation-kafka-python/tests
-  test-instrumentation-confluent-kafka: instrumentation/opentelemetry-instrumentation-confluent-kafka/tests
-  test-instrumentation-logging: instrumentation/opentelemetry-instrumentation-logging/tests
-  test-instrumentation-mysql: instrumentation/opentelemetry-instrumentation-mysql/tests
-  test-instrumentation-mysqlclient: instrumentation/opentelemetry-instrumentation-mysqlclient/tests
-  test-instrumentation-sio-pika-{0,1}: instrumentation/opentelemetry-instrumentation-pika/tests
-  test-instrumentation-aio-pika-{8,9}: instrumentation/opentelemetry-instrumentation-aio-pika/tests
-  test-instrumentation-psycopg: instrumentation/opentelemetry-instrumentation-psycopg/tests
-  test-instrumentation-psycopg2: instrumentation/opentelemetry-instrumentation-psycopg2/tests
-  test-instrumentation-pymemcache-{135,200,300,342,400}: instrumentation/opentelemetry-instrumentation-pymemcache/tests
-  test-instrumentation-pymongo: instrumentation/opentelemetry-instrumentation-pymongo/tests
-  test-instrumentation-pymysql: instrumentation/opentelemetry-instrumentation-pymysql/tests
-  test-instrumentation-pyramid: instrumentation/opentelemetry-instrumentation-pyramid/tests
-  test-instrumentation-redis: instrumentation/opentelemetry-instrumentation-redis/tests
-  test-instrumentation-remoulade: instrumentation/opentelemetry-instrumentation-remoulade/tests
-  test-instrumentation-requests: instrumentation/opentelemetry-instrumentation-requests/tests
-  test-instrumentation-sklearn: instrumentation/opentelemetry-instrumentation-sklearn/tests
-  test-instrumentation-sqlalchemy-{11,14}: instrumentation/opentelemetry-instrumentation-sqlalchemy/tests
-  test-instrumentation-sqlite3: instrumentation/opentelemetry-instrumentation-sqlite3/tests
-  test-instrumentation-starlette: instrumentation/opentelemetry-instrumentation-starlette/tests
-  test-instrumentation-system-metrics: instrumentation/opentelemetry-instrumentation-system-metrics/tests
-  test-instrumentation-tornado: instrumentation/opentelemetry-instrumentation-tornado/tests
-  test-instrumentation-tortoiseorm: instrumentation/opentelemetry-instrumentation-tortoiseorm/tests
-  test-instrumentation-wsgi: instrumentation/opentelemetry-instrumentation-wsgi/tests
-  test-instrumentation-httpx-{18,21}: instrumentation/opentelemetry-instrumentation-httpx/tests
-  test-instrumentation-asyncio: instrumentation/opentelemetry-instrumentation-asyncio/tests
-  test-util-http: util/opentelemetry-util-http/tests
-  test-sdkextension-aws: sdk-extension/opentelemetry-sdk-extension-aws/tests
-  test-resource-detector-container: resource/opentelemetry-resource-detector-container/tests
-  test-propagator-aws: propagator/opentelemetry-propagator-aws-xray/tests
-  test-propagator-ot-trace: propagator/opentelemetry-propagator-ot-trace/tests
-  test-exporter-richconsole: exporter/opentelemetry-exporter-richconsole/tests
-  test-exporter-prometheus-remote-write: exporter/opentelemetry-exporter-prometheus-remote-write/tests
-
 commands_pre =
 ; Install without -e to test the actual installation
   py3{8,9,10,11}: python -m pip install -U pip setuptools wheel
@@ -379,11 +324,15 @@ commands_pre =
 
   distro: pip install {toxinidir}/opentelemetry-distro
 
+  asgi: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-asgi/test-requirements.txt
+
   celery: pip install {toxinidir}/instrumentation/opentelemetry-instrumentation-celery[test]
 
   sio-pika-{0,1}: pip install {toxinidir}/instrumentation/opentelemetry-instrumentation-pika[test]
 
-  aio-pika-{8,9}: pip install {toxinidir}/instrumentation/opentelemetry-instrumentation-aio-pika[test]
+  aio-pika-0: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-aio-pika/test-requirements-0.txt
+  aio-pika-1: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-aio-pika/test-requirements-1.txt
+  aio-pika-2: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-aio-pika/test-requirements-2.txt
 
   kafka-python: pip install {toxinidir}/instrumentation/opentelemetry-instrumentation-kafka-python[test]
 
@@ -391,9 +340,7 @@ commands_pre =
 
   grpc: pip install {toxinidir}/instrumentation/opentelemetry-instrumentation-grpc[test]
 
-  falcon-{1,2,3},flask-{213,220,300},django-{1,2,3,4},pyramid,tornado,starlette,fastapi,aiohttp,asgi,httpx-{18,21},requests,urllib,urllib3v-{1,2},wsgi: pip install {toxinidir}/util/opentelemetry-util-http
-  wsgi,falcon-{1,2,3},flask-{213,220,300},django-{1,2,3,4},pyramid: pip install {toxinidir}/instrumentation/opentelemetry-instrumentation-wsgi[test]
-  asgi,django-{3,4},starlette,fastapi: pip install {toxinidir}/instrumentation/opentelemetry-instrumentation-asgi[test]
+  wsgi: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-wsgi/test-requirements.txt
 
   asyncpg: pip install {toxinidir}/instrumentation/opentelemetry-instrumentation-asyncpg[test]
 
@@ -404,13 +351,18 @@ commands_pre =
 
   boto3sqs: pip install {toxinidir}/instrumentation/opentelemetry-instrumentation-boto3sqs[test]
 
-  falcon-{1,2,3}: pip install {toxinidir}/instrumentation/opentelemetry-instrumentation-falcon[test]
+  falcon-0: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-falcon/test-requirements-0.txt
+  falcon-1: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-falcon/test-requirements-1.txt
+  falcon-2: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-falcon/test-requirements-2.txt
 
-  flask-{213,220,300}: pip install {toxinidir}/instrumentation/opentelemetry-instrumentation-flask[test]
+  flask-0: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-flask/test-requirements-0.txt
+  flask-1: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-flask/test-requirements-1.txt
+  flask-2: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-flask/test-requirements-2.txt
 
-  urllib: pip install {toxinidir}/instrumentation/opentelemetry-instrumentation-urllib[test]
+  urllib: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-urllib/test-requirements.txt
 
-  urllib3v-{1,2}: pip install {toxinidir}/instrumentation/opentelemetry-instrumentation-urllib3[test]
+  urllib3-0: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-urllib3/test-requirements-0.txt
+  urllib3-1: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-urllib3/test-requirements-1.txt
 
   botocore: pip install {toxinidir}/instrumentation/opentelemetry-instrumentation-botocore[test]
 
@@ -418,15 +370,25 @@ commands_pre =
 
   dbapi: pip install {toxinidir}/instrumentation/opentelemetry-instrumentation-dbapi[test]
 
-  django-{1,2,3,4}: pip install {toxinidir}/instrumentation/opentelemetry-instrumentation-django[test]
+  py3{8,9}-test-instrumentation-django-0: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-django/test-requirements-0.txt
+  py3{8,9}-test-instrumentation-django-1: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-django/test-requirements-1.txt
+  py3{8,9}-test-instrumentation-django-2: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-django/test-requirements-2.txt
+  py3{10,11}-test-instrumentation-django-1: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-django/test-requirements-1.txt
+  py3{10,11}-test-instrumentation-django-3: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-django/test-requirements-3.txt
+  pypy3-test-instrumentation-django-0: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-django/test-requirements-0.txt
+  pypy3-test-instrumentation-django-1: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-django/test-requirements-1.txt
 
-  fastapi: pip install {toxinidir}/instrumentation/opentelemetry-instrumentation-fastapi[test]
+  fastapi: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-fastapi/test-requirements.txt
 
   mysql: pip install {toxinidir}/instrumentation/opentelemetry-instrumentation-dbapi {toxinidir}/instrumentation/opentelemetry-instrumentation-mysql[test]
 
-  mysqlclient: pip install {toxinidir}/instrumentation/opentelemetry-instrumentation-dbapi {toxinidir}/instrumentation/opentelemetry-instrumentation-mysqlclient[test]
+  mysqlclient: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-mysqlclient/test-requirements.txt
 
-  pymemcache-{135,200,300,342,400}: pip install {toxinidir}/instrumentation/opentelemetry-instrumentation-pymemcache[test]
+  pymemcache-0: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-0.txt
+  pymemcache-1: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-1.txt
+  pymemcache-2: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-2.txt
+  pymemcache-3: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-3.txt
+  pymemcache-4: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-4.txt
 
   pymongo: pip install {toxinidir}/instrumentation/opentelemetry-instrumentation-pymongo[test]
 
@@ -436,7 +398,7 @@ commands_pre =
 
   pymysql: pip install {toxinidir}/instrumentation/opentelemetry-instrumentation-dbapi {toxinidir}/instrumentation/opentelemetry-instrumentation-pymysql[test]
 
-  pyramid: pip install {toxinidir}/instrumentation/opentelemetry-instrumentation-pyramid[test]
+  pyramid: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-pyramid/test-requirements.txt
 
   sqlite3: pip install {toxinidir}/instrumentation/opentelemetry-instrumentation-dbapi {toxinidir}/instrumentation/opentelemetry-instrumentation-sqlite3[test]
 
@@ -444,13 +406,13 @@ commands_pre =
 
   remoulade: pip install {toxinidir}/instrumentation/opentelemetry-instrumentation-remoulade[test]
 
-  requests: pip install {toxinidir}/instrumentation/opentelemetry-instrumentation-requests[test]
+  requests: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-requests/test-requirements.txt
 
-  starlette: pip install {toxinidir}/instrumentation/opentelemetry-instrumentation-starlette[test]
+  starlette: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-starlette/test-requirements.txt
 
   system-metrics: pip install {toxinidir}/instrumentation/opentelemetry-instrumentation-system-metrics[test]
 
-  tornado: pip install {toxinidir}/instrumentation/opentelemetry-instrumentation-tornado[test]
+  tornado: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-tornado/test-requirements.txt
 
   tortoiseorm: pip install {toxinidir}/instrumentation/opentelemetry-instrumentation-tortoiseorm[test]
 
@@ -458,13 +420,13 @@ commands_pre =
 
   logging: pip install {toxinidir}/instrumentation/opentelemetry-instrumentation-logging[test]
 
-  aio-pika-{8,9}: pip install {toxinidir}/instrumentation/opentelemetry-instrumentation-aio-pika[test]
+  aio-pika-{0,1,2}: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-aio-pika/test-requirements-2.txt
 
-  aiohttp-client: pip install {toxinidir}/instrumentation/opentelemetry-instrumentation-aiohttp-client[test]
+  aiohttp-client: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-aiohttp-client/test-requirements.txt
 
-  aiohttp-server: pip install {toxinidir}/instrumentation/opentelemetry-instrumentation-aiohttp-server[test]
+  aiohttp-server: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-aiohttp-server/test-requirements.txt
 
-  aiopg: pip install {toxinidir}/instrumentation/opentelemetry-instrumentation-dbapi pip install {toxinidir}/instrumentation/opentelemetry-instrumentation-aiopg[test]
+  aiopg: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-aiopg/test-requirements.txt
 
   richconsole: pip install flaky {toxinidir}/exporter/opentelemetry-exporter-richconsole[test]
 
@@ -474,11 +436,18 @@ commands_pre =
 
   sqlalchemy-{11,14}: pip install {toxinidir}/instrumentation/opentelemetry-instrumentation-sqlalchemy[test]
 
-  elasticsearch-{2,5,6}: pip install {toxinidir}/opentelemetry-instrumentation[test] {toxinidir}/instrumentation/opentelemetry-instrumentation-elasticsearch[test]
+  elasticsearch-0: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-elasticsearch/test-requirements-0.txt
+  elasticsearch-1: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-elasticsearch/test-requirements-1.txt
+  elasticsearch-2: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-elasticsearch/test-requirements-2.txt
 
-  asyncio: pip install {toxinidir}/instrumentation/opentelemetry-instrumentation-asyncio[test]
+  asyncio: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-asyncio/test-requirements.txt
 
-  httpx-{18,21}: pip install {toxinidir}/instrumentation/opentelemetry-instrumentation-httpx[test]
+  ; The numbers at the end of the environment names
+  ; below mean these dependencies are being used:
+  ; 0: httpx>=0.18.0,<0.19.0 respx~=0.17.0
+  ; 1: httpx>=0.19.0 respx~=0.20.1
+  httpx-0: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-httpx/test-requirements-0.txt
+  httpx-1: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-httpx/test-requirements-1.txt
 
   sdkextension-aws: pip install {toxinidir}/sdk-extension/opentelemetry-sdk-extension-aws[test]
 
@@ -494,7 +463,62 @@ commands_pre =
   coverage: python {toxinidir}/scripts/eachdist.py install --editable
 
 commands =
-  test: pytest {posargs}
+  test-distro: pytest {toxinidir}/opentelemetry-distro/tests {posargs}
+  test-opentelemetry-instrumentation: pytest {toxinidir}/opentelemetry-instrumentation/tests {posargs}
+  test-instrumentation-aiohttp-client: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-aiohttp-client/tests {posargs}
+  test-instrumentation-aiohttp-server: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-aiohttp-server/tests {posargs}
+  test-instrumentation-aiopg: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-aiopg/tests {posargs}
+  test-instrumentation-asgi: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-asgi/tests {posargs}
+  test-instrumentation-asyncpg: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-asyncpg/tests {posargs}
+  test-instrumentation-aws-lambda: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-aws-lambda/tests {posargs}
+  test-instrumentation-boto: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-boto/tests {posargs}
+  test-instrumentation-botocore: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-botocore/tests {posargs}
+  test-instrumentation-boto3sqs: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-boto3sqs/tests {posargs}
+  test-instrumentation-cassandra: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-cassandra/tests {posargs}
+  test-instrumentation-celery: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-celery/tests {posargs}
+  test-instrumentation-dbapi: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-dbapi/tests {posargs}
+  test-instrumentation-django: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-django/tests {posargs}
+  test-instrumentation-elasticsearch: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-elasticsearch/tests {posargs}
+  test-instrumentation-falcon: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-falcon/tests {posargs}
+  test-instrumentation-fastapi: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-fastapi/tests {posargs}
+  test-instrumentation-flask: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-flask/tests {posargs}
+  test-instrumentation-urllib: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-urllib/tests {posargs}
+  test-instrumentation-urllib3: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-urllib3/tests {posargs}
+  test-instrumentation-grpc: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-grpc/tests {posargs}
+  test-instrumentation-jinja2: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-jinja2/tests {posargs}
+  test-instrumentation-kafka-python: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-kafka-python/tests {posargs}
+  test-instrumentation-confluent-kafka: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-confluent-kafka/tests {posargs}
+  test-instrumentation-logging: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-logging/tests {posargs}
+  test-instrumentation-mysql: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-mysql/tests {posargs}
+  test-instrumentation-mysqlclient: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-mysqlclient/tests {posargs}
+  test-instrumentation-sio-pika: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-pika/tests {posargs}
+  test-instrumentation-aio-pika: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-aio-pika/tests {posargs}
+  test-instrumentation-psycopg: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-psycopg/tests {posargs}
+  test-instrumentation-psycopg2: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-psycopg2/tests {posargs}
+  test-instrumentation-pymemcache: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-pymemcache/tests {posargs}
+  test-instrumentation-pymongo: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-pymongo/tests {posargs}
+  test-instrumentation-pymysql: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-pymysql/tests {posargs}
+  test-instrumentation-pyramid: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-pyramid/tests {posargs}
+  test-instrumentation-redis: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-redis/tests {posargs}
+  test-instrumentation-remoulade: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-remoulade/tests {posargs}
+  test-instrumentation-requests: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-requests/tests {posargs}
+  test-instrumentation-sklearn: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-sklearn/tests {posargs}
+  test-instrumentation-sqlalchemy: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-sqlalchemy/tests {posargs}
+  test-instrumentation-sqlite3: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-sqlite3/tests {posargs}
+  test-instrumentation-starlette: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-starlette/tests {posargs}
+  test-instrumentation-system-metrics: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-system-metrics/tests {posargs}
+  test-instrumentation-tornado: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-tornado/tests {posargs}
+  test-instrumentation-tortoiseorm: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-tortoiseorm/tests {posargs}
+  test-instrumentation-wsgi: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-wsgi/tests {posargs}
+  test-instrumentation-httpx: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-httpx/tests {posargs}
+  test-instrumentation-asyncio: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-asyncio/tests {posargs}
+  test-util-http: pytest {toxinidir}/util/opentelemetry-util-http/tests {posargs}
+  test-sdkextension-aws: pytest {toxinidir}/sdk-extension/opentelemetry-sdk-extension-aws/tests {posargs}
+  test-resource-detector-container: pytest {toxinidir}/resource/opentelemetry-resource-detector-container/tests {posargs}
+  test-propagator-aws: pytest {toxinidir}/propagator/opentelemetry-propagator-aws-xray/tests {posargs}
+  test-propagator-ot-trace: pytest {toxinidir}/propagator/opentelemetry-propagator-ot-trace/tests {posargs}
+  test-exporter-richconsole: pytest {toxinidir}/exporter/opentelemetry-exporter-richconsole/tests {posargs}
+  test-exporter-prometheus-remote-write: pytest {toxinidir}/exporter/opentelemetry-exporter-prometheus-remote-write/tests {posargs}
   coverage: {toxinidir}/scripts/coverage.sh
 
 [testenv:docs]
@@ -537,55 +561,55 @@ commands_pre =
   python -m pip install {env:CORE_REPO}\#egg=opentelemetry-test-utils&subdirectory=tests/opentelemetry-test-utils
   python -m pip install -e {toxinidir}/util/opentelemetry-util-http[test]
   python -m pip install -e {toxinidir}/opentelemetry-instrumentation[test]
-  python -m pip install -e {toxinidir}/instrumentation/opentelemetry-instrumentation-wsgi[test]
+  pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-wsgi/test-requirements.txt
   python -m pip install -e {toxinidir}/instrumentation/opentelemetry-instrumentation-dbapi[test]
-  python -m pip install -e {toxinidir}/instrumentation/opentelemetry-instrumentation-asgi[test]
+  pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-asgi/test-requirements.txt
   python -m pip install -e {toxinidir}/instrumentation/opentelemetry-instrumentation-botocore[test]
   python -m pip install -e {toxinidir}/instrumentation/opentelemetry-instrumentation-boto3sqs[test]
-  python -m pip install -e {toxinidir}/instrumentation/opentelemetry-instrumentation-django[test]
-  python -m pip install -e {toxinidir}/instrumentation/opentelemetry-instrumentation-starlette[test]
+  pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-django/test-requirements-3.txt
+  pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-starlette/test-requirements.txt
   python -m pip install -e {toxinidir}/instrumentation/opentelemetry-instrumentation-grpc[test]
-  python -m pip install -e {toxinidir}/instrumentation/opentelemetry-instrumentation-falcon[test]
+  pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-falcon/test-requirements-2.txt
   python -m pip install -e {toxinidir}/instrumentation/opentelemetry-instrumentation-boto[test]
-  python -m pip install -e {toxinidir}/instrumentation/opentelemetry-instrumentation-flask[test]
+  pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-flask/test-requirements-2.txt
   python -m pip install -e {toxinidir}/instrumentation/opentelemetry-instrumentation-sqlalchemy[test]
   python -m pip install -e {toxinidir}/instrumentation/opentelemetry-instrumentation-cassandra[test]
   python -m pip install -e {toxinidir}/instrumentation/opentelemetry-instrumentation-celery[test]
   python -m pip install -e {toxinidir}/instrumentation/opentelemetry-instrumentation-pika[test]
-  python -m pip install -e {toxinidir}/instrumentation/opentelemetry-instrumentation-aio-pika[test]
+  pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-aio-pika/test-requirements-2.txt
   ; python -m pip install -e {toxinidir}/instrumentation/opentelemetry-instrumentation-sklearn[test]
   python -m pip install -e {toxinidir}/instrumentation/opentelemetry-instrumentation-redis[test]
   python -m pip install -e {toxinidir}/instrumentation/opentelemetry-instrumentation-remoulade[test]
-  python -m pip install -e {toxinidir}/instrumentation/opentelemetry-instrumentation-fastapi[test]
+  pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-fastapi/test-requirements.txt
   python -m pip install -e {toxinidir}/instrumentation/opentelemetry-instrumentation-jinja2[test]
   python -m pip install -e {toxinidir}/instrumentation/opentelemetry-instrumentation-kafka-python[test]
   python -m pip install -e {toxinidir}/instrumentation/opentelemetry-instrumentation-confluent-kafka[test]
   python -m pip install -e {toxinidir}/instrumentation/opentelemetry-instrumentation-logging[test]
-  python -m pip install -e {toxinidir}/instrumentation/opentelemetry-instrumentation-pymemcache[test]
+  pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-4.txt
   python -m pip install -e {toxinidir}/instrumentation/opentelemetry-instrumentation-psycopg[test]
   python -m pip install -e {toxinidir}/instrumentation/opentelemetry-instrumentation-psycopg2[test]
-  python -m pip install -e {toxinidir}/instrumentation/opentelemetry-instrumentation-aiohttp-client[test]
-  python -m pip install -e {toxinidir}/instrumentation/opentelemetry-instrumentation-aiohttp-server[test]
-  python -m pip install -e {toxinidir}/instrumentation/opentelemetry-instrumentation-aiopg[test]
+  pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-aiohttp-client/test-requirements.txt
+  pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-aiopg/test-requirements.txt
+  pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-aiohttp-server/test-requirements.txt
   python -m pip install -e {toxinidir}/instrumentation/opentelemetry-instrumentation-sqlite3[test]
-  python -m pip install -e {toxinidir}/instrumentation/opentelemetry-instrumentation-pyramid[test]
-  python -m pip install -e {toxinidir}/instrumentation/opentelemetry-instrumentation-requests[test]
-  python -m pip install -e {toxinidir}/instrumentation/opentelemetry-instrumentation-urllib[test]
-  python -m pip install -e {toxinidir}/instrumentation/opentelemetry-instrumentation-urllib3[test]
+  pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-pyramid/test-requirements.txt
+  pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-requests/test-requirements.txt
+  pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-urllib/test-requirements.txt
+  pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-urllib3/test-requirements-1.txt
   python -m pip install -e {toxinidir}/instrumentation/opentelemetry-instrumentation-pymysql[test]
   # prerequisite: follow the instructions here https://github.com/PyMySQL/mysqlclient#install
   # for your OS to install the required dependencies
-  python -m pip install -e {toxinidir}/instrumentation/opentelemetry-instrumentation-mysqlclient[test]
+  pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-mysqlclient/test-requirements.txt
   python -m pip install -e {toxinidir}/instrumentation/opentelemetry-instrumentation-pymongo[test]
-  python -m pip install -e {toxinidir}/instrumentation/opentelemetry-instrumentation-elasticsearch[test]
+  pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-elasticsearch/test-requirements-2.txt
   python -m pip install -e {toxinidir}/instrumentation/opentelemetry-instrumentation-asyncpg[test]
-  python -m pip install -e {toxinidir}/instrumentation/opentelemetry-instrumentation-tornado[test]
+  pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-tornado/test-requirements.txt
   python -m pip install -e {toxinidir}/instrumentation/opentelemetry-instrumentation-tortoiseorm[test]
   python -m pip install -e {toxinidir}/instrumentation/opentelemetry-instrumentation-mysql[test]
-  python -m pip install -e {toxinidir}/instrumentation/opentelemetry-instrumentation-httpx[test]
+  pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-httpx/test-requirements-1.txt
   python -m pip install -e {toxinidir}/instrumentation/opentelemetry-instrumentation-aws-lambda[test]
   python -m pip install -e {toxinidir}/instrumentation/opentelemetry-instrumentation-system-metrics[test]
-  python -m pip install -e {toxinidir}/instrumentation/opentelemetry-instrumentation-asyncio[test]
+  pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-asyncio/test-requirements.txt
   python -m pip install -e {toxinidir}/exporter/opentelemetry-exporter-richconsole[test]
   # requires snappy headers to be available on the system
   python -m pip install -e {toxinidir}/sdk-extension/opentelemetry-sdk-extension-aws[test]
@@ -600,30 +624,81 @@ commands =
 [testenv:docker-tests]
 basepython: python3
 deps =
-  pip >= 20.3.3
-  pytest
+  aiopg==1.4.0
+  amqp==5.2.0
+  asgiref==3.7.2
+  async-timeout==4.0.3
   asyncpg==0.27.0
-  docker-compose >= 1.25.2
-  mysql-connector-python ~=  8.0
-  pymongo >= 3.1, < 5.0
-  PyMySQL ~= 0.10.1
+  attrs==23.2.0
+  bcrypt==4.1.2
+  billiard==4.2.0
+  celery==5.3.6
+  certifi==2024.2.2
+  cffi==1.16.0
+  chardet==3.0.4
+  click==8.1.7
+  click-didyoumean==0.3.0
+  click-plugins==1.1.1
+  click-repl==0.3.0
+  cryptography==42.0.5
+  Deprecated==1.2.14
+  distro==1.9.0
+  dnspython==2.6.1
+  docker==5.0.3
+  docker-compose==1.29.2
+  dockerpty==0.4.1
+  docopt==0.6.2
+  exceptiongroup==1.2.0
+  flaky==3.7.0
+  greenlet==3.0.3
+  grpcio==1.62.1
+  idna==2.10
+  importlib-metadata==6.11.0
+  iniconfig==2.0.0
+  jsonschema==3.2.0
+  kombu==5.3.5
+  mysql-connector-python==8.3.0
+  mysqlclient==2.1.1
+  opencensus-proto==0.1.0
+  packaging==24.0
+  paramiko==3.4.0
+  pluggy==1.4.0
+  prometheus_client==0.20.0
+  prompt-toolkit==3.0.43
+  protobuf==3.20.3
   # prerequisite: install libpq-dev (debian) or postgresql-devel (rhel), postgresql (mac)
   # see https://www.psycopg.org/docs/install.html#build-prerequisites
   # you might have to install additional packages depending on your OS
-  psycopg ~= 3.1.17
-  psycopg2 ~= 2.9.5
-  aiopg >= 0.13.0, < 1.3.0
-  sqlalchemy ~= 1.4
-  redis ~= 4.3
-  celery[pytest] >= 4.0, < 6.0
-  protobuf~=3.13
+  psycopg==3.1.18
+  psycopg2==2.9.9
+  psycopg2-binary==2.9.9
+  pycparser==2.21
+  pymongo==4.6.2
+  PyMySQL==0.10.1
+  PyNaCl==1.5.0
+  pyodbc==4.0.39
+  pyrsistent==0.20.0
+  pytest==8.0.2
+  pytest-celery==0.0.0
+  python-dateutil==2.9.0.post0
+  python-dotenv==0.21.1
+  pytz==2024.1
+  PyYAML==5.3.1
+  redis==4.6.0
+  remoulade==3.2.0
   requests==2.25.0
-  # prerequisite: install unixodbc
-  pyodbc~=4.0.30
-  flaky==3.7.0
-  remoulade>=0.50
-  mysqlclient~=2.1.1
-  pyyaml==5.3.1
+  six==1.16.0
+  SQLAlchemy==1.4.52
+  texttable==1.7.0
+  tomli==2.0.1
+  typing_extensions==4.10.0
+  tzdata==2024.1
+  urllib3==1.26.18
+  vine==5.1.0
+  wcwidth==0.2.13
+  websocket-client==0.59.0
+  wrapt==1.16.0
+  zipp==3.18.0
 
 changedir =
   tests/opentelemetry-docker-tests/tests